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Prof Aaron Russell

STAFF PROFILE

Position

Pro Vice-Chancellor, Researcher Development and Integrity

Faculty

Office of DVC (Research)

Department

Office of DVC (Research)

Campus

Melbourne Burwood Campus

Qualifications

Bachelor of Applied Science (Human Movement), Deakin University, 1995
Doctor of Philosophy, Deakin University, 2001
Graduate Certificate of Higher Education, Deakin University, 2008

Contact

pvc-rdi@deakin.edu.au
+61 3 925 17397

Biography summary

2017 - Present : Pro Vice-Chancellor, Researcher Development and Integrity, Deakin University

2014 - Present : Professor, School of Exercise and Nutrition Sciences, Deakin University

2011 - 2013 : Associate Professor, School of Exercise and Nutrition Sciences, Deakin University

2011 : Visiting Research Fellow, The Scripps Research Institute, San Diego, USA

2008 - 2011 : NHMRC Research Fellow, School of Exercise and Nutrition Sciences, Deakin University

2006 - 2008 : Senior Lecturer, School of Exercise and Nutrition Sciences, Deakin University

2002 - 2006 : Head of Molecular Physiology, Clinique Romande de readaption, Sion, Switzerland

2000 - 2002 : Research Fellow, Department of Medical Biochemistry, University of Geneva, Switzerland

Research interests

My research group is focused on determining the molecular factors that control skeletal muscle wasting, growth and regeneration. Investigations are performed in humans using in vivo models of muscle wasting including motor neuron disease (MND), muscular dystrophy (DMD and sarcopenia. Acute and chronic exercise protocols are used as models to investigate the signalling proteins that regulate skeletal muscle growth and regeneration.

 

  • In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.

 

  • In vivo rodent models are used to investigate the role of specific molecular targets using AAV and lentiviral technology.

 

  • Research tools include quantitative PCR, Western blotting, EMSA, Luciferase reporter assays, protein degradation and synthesis assays.

 

  • Molecular targets of interest include PGC-1, STARS and several miRNA species.

Conferences

(Invited Presentation - past 5 years)

2013 Australian Physiological Society Conference (AuPS), Geelong; PGC-1α  and ERRα control of muscle growth.


2013 Australian and New Zealand Obesity Society, Melbourne; microRNA control of brown adipose tissue.


2012 AussieMit - Australian Mitochondria Conference, Melbourne; microRNA¬???23a inhibits PGC-¬1α translation: a new regulator of mitochondrial biogenesis with exercise and disease.


2012 Australian Physiological Society Conference (AuPS), Sydney; Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.

2012 The Gage Muscle Conference, Canberra; STARS as a potential mediator of skeletal muscle growth, regeneration and function.
 

Seminar Presentations


2013 Macquarie University, Australia School of Advanced Medicine, Sydney; Identifying targets to treat amyotrophic lateral sclerosis.


2012  Nestle Research Centre, Lausanne, Switzerland. From cell biology to human physiology: a multidisciplinary approach to maintain health throughout the life span.
 

Awards


 

Publications

Filter by

2017

Striated muscle activator of Rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by miR-628-5p

A Russell, M Wallace, M Kalanon, E Zacharewicz, P Della Gatta, A Garnham, S Lamon

(2017), Vol. 220, pp. 263-274, Acta physiologica, London, Eng., C1

journal

MicroRNA expression patterns in post-natal mouse skeletal muscle development

S Lamon, E Zacharewicz, L Butchart, L Orellana, J Mikovic, M Grounds, A Russell

(2017), Vol. 18, pp. 1-13, BMC genomics, London, Eng., C1

journal

increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients

D Borgia, A Malena, M Spinazzi, M Desbats, L Salviati, A Russell, G Miotto, L Tosatto, E Pegoraro, G Sorarù, M Pennuto, L Vergani

(2017), Vol. 26, pp. 1087-1103, Human Molecular Genetics, Oxford, Eng., C1

journal
2016

Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle

Y Cho, B Hazen, P Gandra, S Ward, S Schenk, A Russell, A Kralli

(2016), Vol. 30, pp. 674-687, FASEB journal, Bethesda, Md., C1

journal

Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: findings of a randomized controlled study

S Mason, P Della Gatta, R Snow, A Russell, G Wadley

(2016), Vol. 93, pp. 227-238, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal

Overexpression of striated muscle activator of Rho signaling (STARS) increases C2C12 skeletal muscle cell differentiation

M Wallace, P Della Gatta, B Mir, G Kowalski, J Kloehn, M McConville, A Russell, S Lamon

(2016), Vol. 7, pp. 1-13, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Ibuprofen ingestion does not affect markers of post-exercise muscle inflammation

L Vella, J Markworth, G Paulsen, T Raastad, J Peake, R Snow, D Cameron-Smith, A Russell

(2016), Vol. 7, pp. 1-9, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle

J Fyfe, D Bishop, E Zacharewicz, A Russell, N Stepto

(2016), Vol. 310, pp. R1297-R1311, American journal of physiology - regulatory, integrative and comparative physiology, Bethesda, Md., C1

journal

Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults

S Lamon, E Zacharewicz, E Arentson-Lantz, P Della Gatta, L Ghobrial, F Gerlinger Romero, A Garnham, D Paddon-Jones, A Russell

(2016), Vol. 7, pp. 1-8, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Skeletal muscle satellite cells, mitochondria, and microRNAs: their involvement in the pathogenesis of ALS

S Tsitkanou, P Della Gatta, A Russell

(2016), Vol. 7, pp. 1-9, Frontiers in psychology, Lausanne, Switzerland, C1

journal

Measures to predict the individual variability of corticospinal responses following transcranial direct current stimulation

N Nuzum, A Hendy, A Russell, W-P Teo

(2016), Vol. 10, pp. 1-12, Frontiers in human neuroscience, Lausanne, Switzerland, C1

journal

Diet quality and telomere length in older Australian men and women.

C Milte, A Russell, K Ball, D Crawford, J Salmon, S McNaughton

(2016), pp. 1-10, European journal of nutrition, Berlin, Germany, C1

journal
2015

Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training

R Stefanetti, S Lamon, M Wallace, M Vendelbo, A Russell, K Vissing

(2015), Vol. 467, pp. 1523-1537, Pflugers archiv - European journal of physiology, Berlin, Germany, C1

journal

MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle

S Wada, S Wada, Y Kato, Y Kato, S Sawada, S Sawada, K Aizawa, K Aizawa, J Park, J Park, A Russell, A Russell, T Ushida, T Ushida, T Akimoto, T Akimoto

(2015), Vol. 467, pp. 389-398, Pflugers Archiv - European journal of physiology, Berlin, Germany, C1

journal

G-CSF treatment can attenuate dexamethasone-induced reduction in C2C12 myotube protein synthesis

C Wright, E Brown, A Ward, A Russell

(2015), Vol. 73, pp. 1-7, Cytokine, Amsterdam, The Netherlands, C1

journal

Predictors and risks of body fat profiles in young New Zealand European, M?ori and Pacific women: study protocol for the women's EXPLORE study.

R Kruger, S Shultz, S McNaughton, A Russell, R Firestone, L George, K Beck, C Conlon, P von Hurst, B Breier, S Jayasinghe, W O'Brien, B Jones, W Stonehouse

(2015), Vol. 4, pp. 128-128, SpringerPlus, Switzerland, C1

journal

Hormonal and metabolic responses to repeated cycling sprints under different hypoxic conditions

M Kon, K Nakagaki, Y Ebi, T Nishiyama, A Russell

(2015), Vol. 25, pp. 121-126, Growth hormone and IGF research, Amsterdam, The Netherlands, C1

journal

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

journal

Statin-induced increases in atrophy gene expression occur independently of changes in PGC1? protein and mitochondrial content

C Goodman, D Pol, E Zacharewicz, R Lee-Young, R Snow, A Russell, G McConell

(2015), Vol. 10, pp. 1-18, PLoS one, San Francisco, Calif., C1

journal

Regulation of granulocyte colony-stimulating factor and its receptor in skeletal muscle is dependent upon the type of inflammatory stimulus

C Wright, E Brown, P Della Gatta, I Fatouros, L Karagounis, G Terzis, G Mastorakos, Y Michailidis, D Mandalidis, K Spengos, A Chatzinikolaou, S Methenitis, D Draganidis, A Jamurtas, A Russell

(2015), Vol. 35, pp. 710-719, Journal of interferon and cytokine research, Larchmont, N.Y., C1

journal

Exercise, skeletal muscle and circulating microRNAs

A Russell, S Lamon

(2015), Vol. 135, pp. 471-496, Progress in molecular biology and translational science, Amsterdam, The Netherlands, C1

journal

Comparative analysis of microRNA expression in mouse and human brown adipose tissue

I Guller, S McNaughton, T Crowley, V Gilsanz, S Kajimura, M Watt, A Russell

(2015), Vol. 16, pp. 1-11, BMC genomics, London, Eng., C1

journal

NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide - but not palmitate-induced toxicity

K Anderson, A Russell, V Foletta

(2015), Vol. 5, pp. 668-681, FEBS open bio, Amsterdam, The Netherlands, C1

journal

Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans

D Morrison, J Hughes, P Della Gatta, S Mason, S Lamon, A Russell, G Wadley

(2015), Vol. 89, pp. 852-862, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program

A Morrison-Nozik, P Anand, H Zhu, Q Duan, M Sabeh, D Prosdocimo, M Lemieux, N Nordsborg, A Russell, C MacRae, A Gerber, M Jain, S Haldar

(2015), Vol. 112, pp. E6780-E6789, Proceedings of the national academy of sciences of the United States of America, Washington, D.C., C1

journal

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

P Sepulveda, S Lamon, A Hagg, R Thomson, C Winbanks, H Qian, C Bruce, A Russell, P Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

journal
2014

Objectively measured muscle fatigue in Crohn's disease: correlation with self-reported fatigue and associated factors for clinical application

D van Langenberg, P Della Gatta, S Warmington, D Kidgell, P Gibson, A Russell

(2014), Vol. 8, pp. 137-146, Journal of Crohn's and colitis, Amsterdam, The Netherlands, C1

journal

High dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.

S Mason, R Baptista, P Della Gatta, A Yousif, A Russell, G Wadley

(2014), Vol. 77, pp. 130-138, Free Radical Biology and Medicine, Amsterdam, The Netherlands, C1

journal

Skeletal muscle mitochondria: a major player in exercise, health and disease.

A Russell, V Foletta, R Snow, G Wadley

(2014), Vol. 1840, pp. 1276-1284, Biochimica et Biophysica Acta - General Subjects, Amsterdam , Netherlands, C1

journal

G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle

C Wright, E Brown, P Della-Gatta, A Ward, G Lynch, A Russell

(2014), Vol. 5, pp. 1-13, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.

A Russell, L Ghobrial, C Wright, S Lamon, E Brown, M Kon, M Skelton, R Snow

(2014), Vol. 5, pp. 1-6, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise.

R Stefanetti, E Zacharewicz, P Della Gatta, A Garnham, A Russell, S Lamon

(2014), Vol. 5, pp. 1-10, Frontiers in Physiology, Lausanne, Switzerland, C1

journal

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

E Dominguez, E Dominguez, A Galmozzi, A Galmozzi, J Chang, J Chang, K Hsu, K Hsu, J Pawlak, J Pawlak, W Li, W Li, C Godio, C Godio, J Thomas, J Thomas, D Partida, D Partida, S Niessen, S Niessen, P O'Brien, P O'Brien, A Russell, A Russell, M Watt, M Watt, D Nomura, D Nomura, B Cravatt, B Cravatt, E Saez, E Saez

(2014), Vol. 10, pp. 113-121, Nature chemical biology, New York, N.Y., C1

journal

The STARS signaling pathway: a key regulator of skeletal muscle function

S Lamon, M Wallace, A Russell

(2014), Vol. 466, pp. 1659-1671, Pflügers archiv - European journal of physiology, Heidelberg, Germany, C1

journal

EPO-receptor is present in mouse C2C12 and human primary skeletal muscle cells but EPO does not influence myogenesis

S Lamon, E Zacharewicz, A Stephens, A Russell

(2014), Vol. 2, pp. 1-22, Physiological reports, Oxford, England, C1

journal

Influence of divergent exercise contraction mode and whey protein supplementation on atrogin-1, MuRF1, and FOXO1/3A in human skeletal muscle

R Stefanetti, S Lamon, S Rahbek, J Farup, E Zacharewicz, M Wallace, M Vendelbo, A Russell, K Vissing

(2014), Vol. 116, pp. 1491-1502, Journal of applied physiology, Bethesda, MD, C1

journal

Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy

J Church, J Trieu, A Chee, T Naim, S Gehrig, S Lamon, C Angelini, A Russell, G Lynch

(2014), Vol. 99, pp. 675-687, Experimental physiology, Chichester, England, C1

journal

Androgenic and estrogenic regulation of Atrogin-1, MuRF1 and myostatin expression in different muscle types of male mice

H De Naeyer, S Lamon, A Russell, I Everaert, A De Spaey, B Vanheel, Y Taes, W Derave

(2014), Vol. 114, pp. 751-761, European journal of applied physiology, heidelberg, Germany, C1

journal

Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease.

D van Langenberg, P Della Gatta, B Hill, E Zacharewicz, P Gibson, A Russell

(2014), Vol. 8, pp. 626-634, Journal of Crohn's and Colitis, Amsterdam, The Netherlands, C1

journal

Ibuprofen supplementation and its effects on NF-?B activation in skeletal muscle following resistance exercise.

L Vella, J Markworth, J Peake, R Snow, D Cameron-Smith, A Russell

(2014), Vol. 2, pp. 1-11, Physiol Rep, United States, C1

journal

New gene targets of PGC-1? and ERR? co-regulation in C2C12 myotubes

A Nsiah-Sefaa, E Brown, A Russell, V Foletta

(2014), Vol. 41, pp. 8009-8017, Molecular biology reports, Amsterdam, The Netherlands, C1

journal

Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise

R Mason, R Meex, A Russell, B Canny, M Watt

(2014), Vol. 9, pp. 1-9, PLoS one, San Francisco, CA, C1

journal

Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

M Kon, N Ohiwa, A Honda, T Matsubayashi, T Ikeda, T Akimoto, Y Suzuki, Y Hirano, A Russell

(2014), Vol. 2, pp. 1-13, Physiology reports, Malden, MA, C1

journal

Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle

E Zacharewicz, P Della Gatta, J Reynolds, A Garnham, T Crowley, A Russell, S Lamon

(2014), Vol. 9, pp. 1-25, PLoS One, San Francisco, Calif., C1

journal
2013

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

A Russell, S Wada, L Vergani, M Hock, S Lamon, B Léger, T Ushida, R Cartoni, G Wadley, P Hespel, A Kralli, G Soraru, C Angelini, T Akimoto

(2013), Vol. 49, pp. 107-117, Neurobiology of disease, Maryland Heights, Mo., C1

journal

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training

A Russell, A Russell, S Lamon, S Lamon, H Boon, H Boon, S Wada, S Wada, I Guller, I Guller, E Brown, E Brown, A Chibalin, A Chibalin, J Zierath, J Zierath, R Snow, R Snow, N Stepto, N Stepto, G Wadley, G Wadley, T Akimoto, T Akimoto

(2013), Vol. 591, pp. 4637-4653, Journal of physiology, Chichester, England, C1-1

journal

Ndrg2 is a PGC-1cx/ERRcx target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes

V Foletta, E Brown, Y Cho, R Snow, A Kralli, A Russell

(2013), Vol. 1833, pp. 3112-3123, Biochimica et Biophysica Acta - Molecular Cell Research, Amsterdam, Netherlands, C1

journal

The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?

S Lamon, A Russell

(2013), Vol. 4, pp. 1-9, Frontiers in physiology, Lausanne, Switzerland, C1-1

journal

MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease

E Zacharewicz, S Lamon, A Russell

(2013), Vol. 4, pp. 1-11, Frontiers in physiology, Lausanne, Switzerland, C1-1

journal

Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training

S Lamon, M Wallace, R Stefanetti, S Rahbek, M Vendelbo, A Russell, K Vissing

(2013), Vol. 465, pp. 1317-1325, Pfluegers Archiv: European journal of physiology, Berlin, Germany, C1-1

journal

Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway

K Vissing, S Rahbek, S Lamon, J Farup, R Stefanetti, M Wallace, M Vendelbo, A Russell

(2013), Vol. 591, pp. 3749-3763, Journal of physiology, London, Eng., C1-1

journal

Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise

Y Michailidis, L Karagounis, G Terzis, A Jamurtas, K Spengos, D Tsoukas, A Chatzinikolaou, D Mandalidis, R Stefanetti, I Papassotiriou, S Athanasopoulos, J Hawley, A Russell, I Fatouros

(2013), Vol. 98, pp. 233-245, American journal of clinical nutrition, Bethesda, Md., C1-1

journal

Peroxisome proliferator-activated receptor ? coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells

Y Cho, B Hazen, A Russell, A Kralli

(2013), Vol. 288, pp. 25207-25218, Journal of biological chemistry, Bethesda, Md., C1-1

journal

Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation

M Wallace, A Russell

(2013), Vol. 305, pp. C414-C426, American journal of physiology: cell physiology, Bethesda, Md., C1-1

journal

Androgen-dependent impairment of myogenesis in spinal and bulbar muscular atrophy

A Malena, M Pennuto, C Tezze, G Querin, C D'Ascenzo, V Silani, G Cenacchi, A Scaramozza, S Romito, L Morandi, E Pegoraro, A Russell, G Sorarù, L Vergani

(2013), Vol. 126, pp. 109-121, Acta neuropathologica, Berlin, Germany, C1-1

journal
2012

Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle

A Russell, M Crisan, B Leger, M Corselli, A McAinch, P O'Brien, D Cameron-Smith, B Peault, L Casteilla, J Giacobino

(2012), Vol. 36, pp. 155-158, International journal of obesity, London, England, C1

journal

HSP72 preserves muscle function and slows progression of severe muscular dystrophy

S Gehrig, C van der Poel, T Sayer, J Schertzer, D Henstridge, J Church, S Lamon, A Russell, K Davies, M Febbraio, G Lynch

(2012), Vol. 484, pp. 394-398, Nature, London, U. K., C1

journal

Resistance exercise increases NF-kB activity in human skeletal muscle

L Vella, M Caldow, A Larsen, D Tassoni, P Della-Gatta, P Gran, A Russell, D Cameron-Smith

(2012), Vol. 302, American journal of physiology, Bethesda, Md., C1

journal

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation

S Haldar, D Jeyaraj, P Anand, H Zhu, Y Lu, D Prosdocimo, B Eapen, D Kawanami, M Okutsu, L Brotto, H Fujioka, J Kerner, M Rosca, O McGuinness, R Snow, A Russell, A Gerber, X Bai, Z Yan, T Nosek, M Brotto, C Hoppel, M Jain

(2012), Vol. 109, pp. 6739-6744, Proceedings of the National Academy of Sciences of the United States of America, Washington D.C., C1

journal

The regulation and function of the striated muscle activator of rho signaling (STARS) protein

M Wallace, S Lamon, A Russell

(2012), Vol. 3, pp. 1-5, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

M Derecka, A Gornicka, S Koralov, K Szczepanek, M Morgan, V Raje, J Sisler, Q Zhang, D Otero, J Cichy, K Rajewsky, K Shimoda, V Poli, B Strobl, S Pellegrini, T Harris, P Seale, A Russell, A McAinch, P O'Brien, S Keller, C Croniger, T Kordula, A Larner

(2012), Vol. 16, pp. 814-824, Cell metabolism, Cambridge, Mass., C1

journal

Visual sensitivity loss in the central 30° of visual field is associated with diabetic peripheral neuropathy

G Sampson, A Shahidi, D Vagenas, N Pritchard, K Edwards, A Russell, R Malik, N Efron

(2012), Vol. 55, pp. 1179-1185, Diabetologia, Heidelberg, Germany, C1-1

journal
2011

The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

V Foletta, L White, A Larsen, B Léger, A Russell

(2011), Vol. 461, pp. 325-335, Pfluegers Archiv: European journal of physiology, Heidelberg, Germany, C1

journal

Age-related changes in the molecular regulation of skeletal muscle mass

A Russell, B Leger

(2011), pp. 207-221, Sarcopenia : age-related muscle wasting and weakness : mechanisms and treatments, Dordrecht, B1

chapter

Striated muscle activator of Rho signalling (STARS) is a PGC-1?/oestrogen-related receptor-? target gene and is upregulated in human skeletal muscle after endurance exercise

M Wallace, M Hock, B Hazen, A Kralli, R Snow, A Russell

(2011), Vol. 589, pp. 2027-2039, Journal of physiology, London, England, C1

journal

Molecular mechanisms of inflammation : anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal

L Lucas, A Russell, R Keast

(2011), Vol. 17, pp. 754-768, Current pharmaceutical design, Bussum, The Netherlands, C1

journal
2010

Maternal creatine supplementation from mid-pregnancy protects the diaphragm of the newborn spiny mouse from intrapartum hypoxia-induced damage

D Cannata, Z Ireland, H Dickinson, R Snow, A Russell, J West, D Walker

(2010), Vol. 68, pp. 393-398, Pediatric research, Baltimore, Md., C1

journal

Molecular regulation of skeletal muscle mass

A Russell

(2010), Vol. 37, pp. 378-384, Clinical and experimental pharmacology & physiology, Richmond, Vic., C1

journal

MicroRNAs in skeletal muscle : their role and regulation in development, disease and function

I Guller, A Russell

(2010), Vol. 588, pp. 4075-4087, The Journal of Physiology, Oxford, England, C1

journal

Corneal sensitivity as an ophthalmic marker of diabetic neuropathy

N Pritchard, K Edwards, D Vagenas, A Shahidi, G Sampson, A Russell, R Malik, N Efron

(2010), Vol. 87, pp. 1003-1008, Optometry and vision science, Philadelphia, PA, C1-1

journal
2009

Regulation of STARS and its downstream target suggest a novel pathway involved in human skeletal hypertrophy and atrophy

S Lamon, M Wallace, B Leger, A Russell

(2009), Vol. 587, pp. 1795-1803, Journal of physiology, Oxford, England, C1

journal

Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse

Z Ireland, A Russell, T Wallimann, D Walker, R Snow

(2009), Vol. 9, pp. 1-12, BMC developmental biology, London, England, C1

journal

Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more

C Liongue, C Wright, A Russell, A Ward

(2009), Vol. 41, pp. 2372-2375, International journal of biochemistry and cell biology, Amsterdam, The Netherlands, C1

journal

PPARy inhibits NF-B-dependent transcriptional activation in skeletal muscle

A Remels, R Langen, H Gosker, A Russell, F Spaapen, J Voncken, P Schrauwen, A Schols

(2009), Vol. 297, American journal of physiology- endocrinology and metabolism, Bethesda, Md., C1-1

journal

Atrogin-1, MuRF1, and FoXo, as well as phosphorylated GSK-3? and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients

B Léger, R Senese, A Al-Khodairy, O Dériaz, C Gobelet, J Giacobino, A Russell

(2009), Vol. 40, pp. 69-78, Muscle and nerve, Hoboken, N.J., C1-1

journal
2008

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase

S Summermatter, D Mainieri, A Russell, J Montani, J Seydoux, A Buchala, G Solinas, A Dulloo

(2008), Vol. 22, pp. 774-785, The FASEB journal : official publication of the Federation of American Societies for experimental biology, [Bethesda, Md.], C1

journal

Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation

B Leger, W Derave, K De Bock, P Hespel, A Russell

(2008), Vol. 11, pp. 163-175, Rejuvenation research, New Rochelle, N.Y., C1

journal

A reservoir of brown adipocyte progenitors in human skeletal muscle

M Crisan, L Casteilla, L Lehr, M Carmona, A Paolini-Giacobino, S Yap, B Sun, B Léger, A Logar, L Penicaud, P Schrauwen, D Cameron-Smith, A Russell, B Peault, J Giacobino

(2008), Vol. 26, pp. 2425-2433, Stem cells : the international journal of cell differentiation and proliferation, Dayton, Oh., C1

journal
2007

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1? and PPARß/? gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus

M Mensink, M Hesselink, A Russell, G Schaart, J Sels, P Schrauwen

(2007), Vol. 31, pp. 1301-1310, International journal of obesity, London, England, C1

journal

Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants

L Vergani, A Malena, P Sabatelli, E Loro, L Cavallini, P Magalhaes, L Valente, F Bragantini, F Carrara, B Leger, J Poulton, A Russell, I Holt

(2007), Vol. 130, pp. 2715-2724, Brain: a journal of neurology, Oxford, England, C1

journal

Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene (PGC1A) during weight loss is related to insulin sensitivity but not to energy expenditure

G Gastaldi, A Russell, A Golay, J Giacobino, F Habicht, V Barthassat, P Muzzin, E Bobbioni-Harsch

(2007), Vol. 50, pp. 2348-2355, Diabetologia: clinical and experimental diabetes and metabolism, Berlin , Germany, C1

journal

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease

M Doucet, A Russell, B Léger, R Debigare, D Joanisse, M Caron, P LeBlanc, F Maltais

(2007), Vol. 176, pp. 261-269, American journal of respiratory and critical care medicine, New York, N. Y., C1

journal

Slow component of VO2 during level and uphill treadmill running : relationship to aerobic fitness in endurance runners

V Reis, L Guidetti, J Duarte, A Ascensao, A Silva, J Sampaio, A Russell, C Baldari

(2007), Vol. 47, pp. 135-140, Journal of sports medicine and physical fitness, Torino, Italy, C1-1

journal
2006

Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1

B Leger, L Vergani, G Soraru, P Hespel, W Derave, C Gobelet, C D`Ascenzio, C Angelini, A Russell

(2006), Vol. 20, pp. 583-585, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

D Mainieri, S Summermatter, J Seydoux, J Montani, S Rusconi, A Russell, O Boss, A Buchala, A Dulloo

(2006), Vol. 20, pp. 1157-1170, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

Peroxisome proliferator-activated receptor-? coactivator-1 and insulin resistance: acute effect of fatty acids

J Hoeks, M Hesselink, A Russell, M Mensink, W Saris, R Mensink, P Schrauwen

(2006), Vol. 49, pp. 2419-2426, Diabetologia, Heidelberg, Germany, C1-1

journal

Reduced Skeletal Muscle Uncoupling Protein-3 Content in Prediabetic Subjects and Type 2 Diabetic Patients: Restoration by Rosiglitazone Treatment

P Schrauwen, M Mensink, G Schaart, E Monen-Kornips, J Sels, E Blaak, A Russell, M Hesselink

(2006), Vol. 91, pp. 1520-1525, Journal of clinical endocrinology and metabolism, Chevy Chase, Md., C1-1

journal

Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy

B Leger, R Cartoni, M Praz, S Lamon, O Deriaz, A Crettenand, C Gobelet, P Rohmer, M Konzelmann, F Luthi, A Russell

(2006), Vol. 576, pp. 923-933, Journal of physiology, West Sussex, England, C1-1

journal
2005

PGC-1? and exercise: important partners in combating insulin resistance

A Russell

(2005), Vol. 1, pp. 175-181, Current diabetes reviews, Bussum, Netherlands, C1-1

journal

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes.

A Civitarese, M Hesselink, A Russell, E Ravussin, P Schrauwen

(2005), Vol. 289, pp. 1023-1029, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1-1

journal

Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise

A Russell, M Hesselink, S Lo, P Schrauwen

(2005), Vol. 19, pp. 986-988, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat. A link between catch-up growth and later metabolic syndrome.

P Cettour-Rose, S Sonia, A Russell, S Summermatter, D Mainieri, C Carrillo-Theander, J Montani, J Seydoux, F Rohner-Jeanrenaud, A Dulloo

(2005), Vol. 54, pp. 751-756, Diabetes, New York, N.Y., C1-1

journal

Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans

K De Bock, E Richter, A Russell, B Eijnde, W Derave, M Ramaekers, E Konickz, B Leger, J Verhaeghe, P Hespel

(2005), Vol. 564, pp. 649-660, Journal of applied physiology, Bethesda, Md., C1-1

journal

Effect of 2 weeks of endurance training on uncoupling protein3 content in untrained human subjects

P Schrauwen, A Russell, E Moonen-Kornips, N Boon, M Hesselink

(2005), Vol. 183, pp. 273-280, Acta physiologica, Oxford, England, C1-1

journal

Mitofusions1/2 and ERR? expression are increased in human skeletal muscle after physical exercise.

R Cartoni, B Leger, M Hock, M Praz, A Crettenand, S Pich, J Ziltener, F Luthi, O Deriaz, A Zorzano, C Gobelet, A Kralli, A Russell

(2005), Vol. 567, pp. 349-358, Journal of physiology, London, England, C1-1

journal
2004

Lipotoxicity: the obese and endurance-trained paradox

A Russell

(2004), Vol. 28, International journal of obesity, London, England, C1-1

journal

Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines

L Vergani, M Floreani, A Russell, M Ceccon, E Napoli, A Cabrelle, L Valente, F Bragantini, B Leger, F Dabbeni-Sala

(2004), Vol. 271, pp. 3646-3656, European journal of biochemistry, Oxford, England, C1-1

journal

COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers.

A Russell, E Somm, R Debigare, O Hartley, D Richard, G Giacomo, A Melotti, A Michaud, J Giacobino, P Muzzin, P LeBlanc, M Francois

(2004), Vol. 24, pp. 332-339, Journal of cardiopulmonary rehabilitation, Philadelphia, Pa., C1-1

journal
2003

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-[gamma] coactivator-1 and peroxisome proliferator-activated receptor-[alpha] in skeletal muscle

A Russell, J Feilchenfeldt, S Schreiber, M Praz, A Crettenand, C Gobelet, C Meier, D Bell, A Kralli, J Giacobino, O Deriaz

(2003), Vol. 52, pp. 2874-2881, Diabetes, New York, N.Y., C1-1

journal

Decreased fatty acit Â-oxidation in riboflavin-responsive, multiple acylocoenzyme a dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3

A Russell, P Schrauwen, E Somm, G Gastaldi, M Hesselink, G Schaart, E Kornips, S Lo, D Bufano, J Giacobino, P Muzzin, M Ceccon, C Angelini, L Vergani

(2003), Vol. 88, pp. 5921-5926, Journal of clinical endocrinology and metabolism, Chevy Chase, MD, C1-1

journal

UCP3 protein regulation in human skeletal muscle fibre types I, IIa andIIx is dependent on exercise intensity.

A Russell, E Somm, M Praz, A Crettenand, O Hartley, A Melotti, J Giacobino, P Muzzin, C Gobelet, O Deriaz

(2003), Vol. 550, pp. 855-861, Journal of physiology, London, England, C1-1

journal

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

A Russell, G Gastaldi, E Bobbioni-Harsch, P Arboit, C Gobelet, O Deriaz, A Golay, J Witztum, J Giacobino

(2003), Vol. 551, pp. 104-106, FEBS letter, Amsterdam, The Netherlands, C1-1

journal

UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects

A Russell, G Wadley, M Hesselink, G Schaart, S Lo, B Léger, A Garnham, E Kornips, D Cameron-Smith, J Giacobino, P Muzzin, R Snow, P Schrauwen

(2003), Vol. 445, pp. 563-569, Pfluegers Archiv : European journal of physiology, Berlin, Germany, C1

journal
2002

Improving the precision of the accumulated oxygen deficit using VO2-power regression points from below and above the lactate threshold

A Russell, P Le Rossignol, R Snow, S Lo

(2002), Vol. 5, pp. 23-31, Journal of Exercise Physiology Online, Duluth Minn, C1

journal

Cycling at 120 when compared to 80 rev/min increases the accumulated oxygen deficit but does not affect the precision of its calculation

A Russell, P Le Rossignol, R Snow, S Lo

(2002), Vol. 5, pp. 32-38, Journal of exercise physiology online, Duluth, Minn., C1

journal

Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity

A Russell, G Wadley, R Snow, J Giacobino, P Muzzin, A Garnham, D Cameron-Smith

(2002), Vol. 26, pp. 157-164, International journal of obesity: and related metabolic disorders, Hampshire, England, C1

journal

Effect of accurate exercise on uncoupling protein3 is a fat metabolism-mediated effect

P Schrauwen, M Hesselink, I Vaartjes, E Kornips, W Saris, J Giacobino, A Russell

(2002), Vol. 282, American journal of physiology: endocrinology and metabolism, Oxford, England, C1-1

journal

Expression of uncoupling protein-3 subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its moduclation by fasting

M Jimenez, C Yvon, L Lehr, B Leger, P Keller, A Russell, F Kuhne, P Flandin, J Giacobino, P Muzzin

(2002), Vol. 269, pp. 2878-2884, The FEBS journal, Oxford, England, C1-1

journal

ß1/ß2/ß3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting

M Jimenez, B Léger, K Canola, L Lehr, P Arboit, J Seydoux, A Russell, J Giacobino, P Muzzin, F Prietner

(2002), Vol. 530, pp. 37-40, FEBS letters, Amsterdam, The Netherlands, C1-1

journal

Skeletal muscle htererogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPAR? and key enzymes of lipid oxidation

S Samec, J Seydoux, A Russell, J Montani, A Dulloo

(2002), Vol. 445, pp. 80-86, Pfluegers Archiv: European Journal of Physiology, Berlin, Germany, C1-1

journal

Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity

A Russell, G Wadley, R Snow, J Giacobino, P Muzzin, A Garnham, D Cameron-Smith

(2002), Vol. 26, pp. 157-164, International journal of obesity, London, Eng., C1-1

journal

Old and new determinants in the regulation of energy expenditure

A Russell, J Giacobino

(2002), Vol. 25, pp. 862-866, Journal of endocrinological investigation, Cham, Switzerland, C1-1

journal
1999

Effects of practice and preferred rate on perceived exertion, metabolic variables and movement control

W Sparrow, K Hughes, A Russell, P Le Rossignol

(1999), Vol. 18, pp. 137-153, Human movement science, Amsterdam, The Netherlands, C1-1

journal
1998

Prediction of elite schoolboy 2000-m rowing ergometer performance from metabolic, anthropometric and strength variables

A Russell, P Le Rossignol, W Sparrow

(1998), Vol. 16, pp. 749-754, Journal of sports sciences, Abingdon, Eng., C1-1

journal

Funded Projects at Deakin

Australian Competitive Grants

Molecular targets involved with human muscle atrophy and hypertrophy

Prof Aaron Russell

NHMRC CDF - Career Development Fellowship

  • 2011: $97,768
  • 2010: $96,040
  • 2009: $94,250
  • 2008: $92,500

The role of Notch signalling in muscular dystrophy

Prof Aaron Russell, Prof Gordon Lynch

NHMRC Project Grant

  • 2011: $34,136
  • 2010: $35,890
  • 2009: $37,643

Skeletal muscle CD34+cells as targets to increase energy expenditure and insulin

Prof Aaron Russell

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2011: $58,940

Role of STARS signalling in maintaining skeletal muscle mass and function; implications for our ageing population

Prof Aaron Russell, Prof Gordon Lynch

NHMRC Project Grant

  • 2016: $44,155
  • 2015: $83,226
  • 2014: $68,857
  • 2013: $44,777

Inhibiting microRNA-23 as a therapeutic strategy to treat amyotrophic lateral sclerosis (ALS)

Prof Aaron Russell, A/Prof Roger Chung

Motor Neurone Disease Research Institute of Australia Research Grants

  • 2014: $56,975

Other Public Sector Funding

Dermatan sulphate as a nutraceutical for application in the field of muscle growth: the effect of dermatan sulphate on human muscle cells

A/Prof David Cameron-Smith, A/Prof Tim Crowe, Prof Aaron Russell

  • 2009: $20,000
  • 2008: $80,000

Physiological effects on volunteer fire fighters during fire supression of Australian bushfires

Prof Aaron Russell, Mr Matthew Phillips

  • 2009: $12,500

Exercise Open Treadmill with Shock for Rats and Mice. C-Pace Cell Culture EP stimulator with EHV100.

Prof Aaron Russell

  • 2013: $34,343

Industry and Other Funding

Molecular mechanisms regulating mitochondrial development and function in the skeletal muscle of ALS patients.

Prof Aaron Russell

  • 2007: $26,503
  • 2006: $26,936

Health benefits of long-term strength training in patients with chronic kidney disease.

Dr Aaron Petersen, Prof L McMahon, Prof Aaron Russell, Dr Gaele Ducher

  • 2009: $25,000

Regulation of post-exercise recovery: Understanding the mechanisms of muscle inflammation and repair

Prof Aaron Russell, Mr Luke Vella, Prof Rod Snow

  • 2013: $2,000

Rescuing the STARS protein as a treatment for muscular dystrophy

Prof Aaron Russell, Prof Gordon Lynch, Dr Paul Della Gatta

  • 2014: $12,440

Supervisions

Principal Supervisor
2016

Evelyn Zacharewicz

Thesis entitled: The Role of MicroRNAs in Regulating Muscle Protein Synthesis

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2014

Renae Stefanetti

Thesis entitled: Atrogin-1 and MURF-1 signalling in human skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Isabelle Guller

Thesis entitled: MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2013

Craig Wright

Thesis entitled: ROLE AND REGULATION OF G-CSF AND ITS RECEPTOR IN MUSCLE

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Erin Brown

Thesis entitled: The role of PGC-1a and PGC-1b in skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Marita Wallace

Thesis entitled: The role and regulation of stars in skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Patricio Sepulveda

Thesis entitled: Development of Novel interventions to enhance muscle function

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2011

Matthew Phillips

Thesis entitled: Pre-cursors to Physical Employment Standards for Rural Tanker-based Bushfire Suppression Work

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

Associate Supervisor
2017

Yasmin Asif

Thesis entitled: Impact of exercise early in life on the adult heart

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2016

Kimberley Catania

Thesis entitled: NDRG2 overexpression effects on skeletal muscle cell growth & stress-response

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2015

Lisa Parkinson

Thesis entitled: The Perceptual and Anti-Inflammatory effects of Oleocanthal, an Olive Oil Phenolic

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2014

Shaun Mason

Thesis entitled: Treatment of Type 2 Diabetes with antioxidant vitamin C therapy

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2012

James Markworth

Thesis entitled: Inflammatory signaling in skeletal muscle cell growth

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2011

Petra Gran

Thesis entitled: Anabolic Signalling in Skeletal Muscle: Impact of Diet and Disease

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences