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Prof Aaron Russell

STAFF PROFILE

Position

Associate Head Of School (Research)

Faculty

Faculty of Health

Department

School of Exercise & Nut. Sci.

Campus

Melbourne Burwood Campus

Qualifications

Bachelor of Applied Science (Human Movement), Deakin University, 1995
Doctor of Philosophy, Deakin University, 2001
Graduate Certificate of Higher Education, Deakin University, 2008

Contact

aaron.russell@deakin.edu.au
+61 3 925 17397

Biography summary

2014 - present Professor, School of Exercise and Nutrition Sciences, Deakin University

2011-13 Associate Professor, School of Exercise and Nutrition Sciences, Deakin University

2011 Visiting Research Fellow, The Scripps Research Institute, San Diego, USA

2008-2011 NHMRC Research Fellow, School of Exercise and Nutrition Sciences, Deakin University

2006-2008 Senior Lecturer, School of Exercise and Nutrition Sciences, Deakin University

2002-2006 Head of Molecular Physiology, Clinique Romande de readaption, Sion, Switzerland

2000-2002 Research Fellow, Department of Medical Biochemistry, University of Geneva, Switzerland

Research interests

My research group is focused on determining the molecular factors that control skeletal muscle wasting, growth and regeneration. Investigations are performed in humans using in vivo models of muscle wasting including motor neuron disease (MND), muscular dystrophy (DMD and sarcopenia. Acute and chronic exercise protocols are used as models to investigate the signalling proteins that regulate skeletal muscle growth and regeneration.

 

  • In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.

 

  • In vivo rodent models are used to investigate the role of specific molecular targets using AAV and lentiviral technology.

 

  • Research tools include quantitative PCR, Western blotting, EMSA, Luciferase reporter assays, protein degradation and synthesis assays.

 

  • Molecular targets of interest include PGC-1, STARS and several miRNA species.

Affiliations

Australia Physiological Society 

Australian Society for Medical Research 

Swiss Australian Academic Network

Teaching interests

Undergraduate

HSE303 Exercise Metabolism
HBS400 – Honours pratical training

Supervised 6 Honours students to completion (all recieving H1 grades with a Scholarship)

Post Graduate

Supervised 8 PhD students to completion

Knowledge areas

Regulation of skeletal muscle growth, wasting and regeneration with exercise and disease.

Molecular signaling in skeletal muscle with exercise, nutrition and disease.

Conferences

(Invited presentation - past 5 years)

2013 Australian Physiological Society Conference (AuPS), Geelong; PGC-1α  and ERRα control of muscle growth.
2013 Australian and New Zealand Obesity Society, Melbourne; microRNA control of brown adipose tissue.
2012 AussieMit - Australian Mitochondria Conference, Melbourne; microRNA¬???23a inhibits PGC-¬1α translation: a new regulator of mitochondrial biogenesis with exercise and disease.
2012 Australian Physiological Society Conference (AuPS), Sydney; Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.
2010  European Muscle Conference, Padova, Italy; PGC-1α/β increase protein synthesis in C2C12 myotubes.
2012 The Gage Muscle Conference, Canberra; STARS as a potential mediator of skeletal muscle growth, regeneration and function.
2010 The Gage- Curtain Muscle Conference, Canberra Australia. PGC-1α regulates protein synthesis and growth related microRNAs: a potential target for combating muscle wasting.
2008 Australian Physiological Society Conference (AuPS), Melbourne. Molecular mechanisms regulating muscle mass.
2008 3rd Australian Association for Exercise and Sports Science (AAESS) Conference, Melbourne;  Molecular Modelling of Muscle Mass.

Seminar Presentations
2013 Macquarie University, Australia School of Advanced Medicine, Sydney; Identifying targets to treat amyotrophic lateral sclerosis.
2012  Nestle Research Centre, Lausanne, Switzerland. From cell biology to human physiology: a multidisciplinary approach to maintain health throughout the life span.
2011  Brock University, St Catherines, Canada; Novel roles and regulators of PGC-1α: implications for skeletal muscle health.
2011  The Scripps Research Institute, San Diego, USA; Identifying miRNAs involved in the differentiation of skeletal muscle-derived CD34+ cells into brown adipocytes.
2010 Dairy Health and Nutrition Consortium Muscle Maintenance Summit. Molecular factors controlling skeletal muscle wasting, growth and regeneration.
2009 Monash University, Department of Physiology Seminar Series; Regulation of skeletal muscle mass: influence of PGC-1α.

Professional activities

Editorial roles

2014 -present Pflugers Archives: European Journal of Physiology
2011-present Frontiers in Striated Muscle Physiology
 

Grant Reviewer

National Research Agency (France)

AFM (France)

Australian Research Council

Health Research Board, (Ireland)

Diabetes Australia Research Trust

NHMRC Project Grants

The Italian Telethon Grant (Italy)

Wellcome Trust (UK)

Awards

2009 Deakin University Award for Research Excellence

2008 - NHMRC Biomedical Career Development Award. Molecular
targets involved in human muscle atrophy and hypertrophy.

2003 - Best oral presentation.3rd Swiss Interfaculty Conference of Sport and Health, November 2003, Lausanne, Switzerland. Endurance training in humans leads to fibre type-specific increases in skeletal muscle αlevels of PGC-1α and PPAR.
 

Projects

Role and regulation of STARS signaling in skeletal muscle health; exercise, ageing and muscular dystrophies.

miRNA regulation of muscle adapation to exercise and disease.

The role of miRNAs in age-related muscle wasting (sarcopenia).

PGC-1alpha and beta as regulators of muscle growth and repair.

Publications

Filter by

2016

Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: findings of a randomized controlled study

Mr Shaun Mason, Dr Paul Della Gatta, Prof Rod Snow, Prof Aaron Russell, Dr Glenn Wadley

(2016), Vol. 93, pp. 227-238, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal

Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle

Yoshitake Cho, Bethany C. Hazen, Paulo Gandra, Samuel Ward, Simon Schenk, Prof Aaron Russell, Anastasia Kralli

(2016), Vol. 30, pp. 674-687, FASEB journal, Bethesda, Md., C1

journal

Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle

Jackson Fyfe, David Bishop, Miss Evelyn Zacharewicz, Prof Aaron Russell, Nigel K Stepto

(2016), Vol. 310, pp. R1297-R1311, American journal of physiology - regulatory, integrative and comparative physiology, Bethesda, Md., C1

journal
2015

MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle.

Shogo Wada, Yoshio Kato, Shuji Sawada, Katsuji Aizawa, Jong-Hoon Park, Prof Aaron Russell, Takashi Ushida, Takayuki Akimoto

(2015), Vol. 467, pp. 389-398, Pfluegers Archiv: European journal of physiology, Germany, C1

journal

Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training

Miss Renae Stefanetti, Dr Severine Lamon, Miss Marita Wallace, Mikkel H Vendelbo, Prof Aaron Russell, A/Prof Kristian Vissing

(2015), Vol. 467, pp. 1523-1537, Pflugers archiv - European journal of physiology, Berlin, Germany, C1

journal

Predictors and risks of body fat profiles in young New Zealand European, Māori and Pacific women: study protocol for the women's EXPLORE study.

Rozanne Kruger, Sarah Shultz, A/Prof Sarah Mcnaughton, Prof Aaron Russell, Ridvan Firestone, Lily George, Kathryn Beck, Cathryn Conlon, Pamela von Hurst, Bernhard Breier, Shakeela Jayasinghe, Wendy OBrien, Beatrix Jones, Welma Stonehouse

(2015), Vol. 4, pp. 128-, SpringerPlus, Switzerland, C1

journal

G-CSF treatment can attenuate dexamethasone-induced reduction in C2C12 myotube protein synthesis

Dr Craig Wright, Miss Erin Brown, Prof Alister Ward, Prof Aaron Russell

(2015), Vol. 73, pp. 1-7, Cytokine, Amsterdam, The Netherlands, C1

journal

Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass

Helene De Naeyer, Dr Severine Lamon, Prof Aaron Russell, Inge Everaert, Annelies De Spaey, Cecile Jamart, Bert Vanheel, Youri Taes, Wim Derave

(2015), Vol. 52, pp. 278-288, Muscle & nerve, London, Eng., C1

journal

Statin-induced increases in atrophy gene expression occur independently of changes in PGC1α protein and mitochondrial content

Craig Goodman, Derk Pol, Miss Evelyn Zacharewicz, Dr Robert Lee-Young, Prof Rod Snow, Prof Aaron Russell, Dr Glenn McConell

(2015), Vol. 10, pp. 1-18, PLoS one, San Francisco, Calif., C1

journal

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

Mr Patricio Sepulveda, Dr Severine Lamon, Adam Hagg, Ms Rachel Thomson, Catherine E Winbanks, Hongwei Qian, Dr Clinton Bruce, Prof Aaron Russell, Dr Paul Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

journal

Comparative analysis of microRNA expression in mouse and human brown adipose tissue

Ms Isabelle Guller, A/Prof Sarah Mcnaughton, Dr Tamsyn Crowley, Vicente Gilsanz, Shingo Kajimura, Matthew J Watt, Prof Aaron Russell

(2015), Vol. 16, pp. 1-11, BMC genomics, London, Eng., C1

journal

Regulation of granulocyte colony-stimulating factor and its receptor in skeletal muscle is dependent upon the type of inflammatory stimulus

Dr Craig Wright, Miss Erin Brown, Dr Paul Della Gatta, Ioannis Fatouros, Leonidas Karagounis, Gerasimos Terzis, Georgios Mastorakos, Yannis Michailidis, Dimitris Mandalidis, Kontantinos Spengos, Athanasios Chatzinikolaou, Spiros Methenitis, Dimitrios Draganidis, Athanasios Jamurtas, Prof Aaron Russell

(2015), Vol. 35, pp. 710-719, Journal of interferon and cytokine research, Larchmont, N.Y., C1

journal

Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans

Mr Dale Morrison, Mr Jed Hughes, Dr Paul Della Gatta, Mr Shaun Mason, Dr Severine Lamon, Prof Aaron Russell, Dr Glenn Wadley

(2015), Vol. 89, pp. 852-862, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal

Hormonal and metabolic responses to repeated cycling sprints under different hypoxic conditions

Michihiro Kon, Kohei Nakagaki, Yoshiko Ebi, Tetsunari Nishiyama, Prof Aaron Russell

(2015), Vol. 25, pp. 121-126, Growth hormone and IGF research, Amsterdam, The Netherlands, C1

journal

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program

Alexander Morrison-Nozik, Priti Anand, Han Zhu, Qiming Duan, Mohamad Sabeh, Domenick A. Prosdocimo, Madeleine Lemieux, Nikolai Nordsborg, Prof Aaron Russell, Calum MacRae, Anthony N. Gerber, Mukesh K. Jain, Saptarsi M. Haldar

(2015), Vol. 112, pp. E6780-E6789, Proceedings of the national academy of sciences of the United States of America, Washington, D.C., C1

journal

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

Dr Ahrathy Selathurai, Dr Greg Kowalski, Micah Burch, Mr Patricio Sepulveda, Steve Risis, Dr Robert Lee-Young, Dr Severine Lamon, A/Prof Peter Meikle, Dr Amanda Genders, A/Prof Sean Mcgee, Matthew J Watt, Prof Aaron Russell, Matthew Frank, Suzanne Jackowski, Prof Mark Febbraio, Dr Clinton Bruce

(2015), Vol. 21, pp. 718-730, Cell metabolism, United States, C1

journal

NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide - but not palmitate-induced toxicity

Kimberley Anderson, Prof Aaron Russell, Dr Torie Foletta

(2015), Vol. 5, pp. 668-681, FEBS open bio, London, Eng., C1

journal

Exercise, skeletal muscle and circulating microRNAs

Prof Aaron Russell, Dr Severine Lamon

(2015), Vol. 135, pp. 471-496, Progress in molecular biology and translational science, Amsterdam, The Netherlands, C1

journal
2014

Objectively measured muscle fatigue in Crohn's disease: correlation with self-reported fatigue and associated factors for clinical application

Russell D. R. van Landenberg, Dr Paul Della Gatta, Dr Stuart Warmington, Dr Dawson Kidgell, Peter R Gibson, Prof Aaron Russell

(2014), Vol. 8, pp. 137-146, Journal of Crohn's and colitis, Amsterdam, The Netherlands, C1

journal

Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease.

D. R. Van Langenberg, Dr Paul Della Gatta, Dr Briony Hill, Miss Evelyn Zacharewicz, Peter R Gibson, Prof Aaron Russell

(2014), Vol. 8, pp. 626-634, Journal of Crohn's and Colitis, Amsterdam, The Neverlands, C1

journal

EPO-receptor is present in mouse C2C12 and human primary skeletal muscle cells but EPO does not influence myogenesis.

Dr Severine Lamon, Miss Evelyn Zacharewicz, Andrew Stephens, Prof Aaron Russell

(2014), Vol. 2, pp. 1-22, Physiological reports, Oxford, England, C1

journal

The STARS signaling pathway: a key regulator of skeletal muscle function

Dr Severine Lamon, Miss Marita Wallace, Prof Aaron Russell

(2014), Vol. 466, pp. 1659-1671, Pflügers archiv - European journal of physiology, Heidelberg, Germany, C1

journal

Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy.

Jarrod E. Church, Jennifer Trieu, Annabel Chee, Timur Naim, Stefan M. Gehrig, Dr Severine Lamon, Corrado Angelini, Prof Aaron Russell, Prof Gordon Lynch

(2014), Vol. 99, pp. 675-687, Experimental physiology, Chichester, England, C1

journal

Androgenic and estrogenic regulation of Atrogin-1, MuRF1 and myostatin expression in different muscle types of male mice

H De Naeyer, Dr Severine Lamon, Prof Aaron Russell, I Everaert, A De Spaey, B Vanheel, Y Taes, W Derave

(2014), Vol. 114, pp. 751-761, European journal of applied physiology, heidelberg, Germany, C1

journal

Skeletal muscle mitochondria : a major player in exercise, health and disease.

Prof Aaron Russell, Dr Torie Foletta, Prof Rod Snow, Dr Glenn Wadley

(2014), Vol. 1840, pp. 1276-1284, Biochimica et Biophysica Acta - General Subjects, Amsterdam , Netherlands, C1

journal

Ibuprofen supplementation and its effects on NF-κB activation in skeletal muscle following resistance exercise

Mr Luke Vella, James F Markworth, Jonathon Peake, Prof Rod Snow, A/Prof David Cameron-Smith, Prof Aaron Russell

(2014), Vol. 2, pp. 1-11, Physiological reports, United States, C1

journal

New gene targets of PGC-1α and ERRα co-regulation in C2C12 myotubes

Abena Nsiah-Sefaa, Miss Erin Brown, Prof Aaron Russell, Dr Torie Foletta

(2014), Vol. 41, pp. 8009-8017, Molecular biology reports, Amsterdam, The Netherlands, C1

journal

Effects of systemic hypoxia on human muscular adaptations to resistance exercise training

Michihiro Kon, Nao Ohiwa, Akiko Honda, Takeo Matsubayashi, Tatsuaki Ikeda, Takayuki Akimoto, Yasuhiro Suzuki, Yuichi Hirano, Prof Aaron Russell

(2014), Vol. 2, pp. 1-13, Physiology reports, Malden, MA, C1

journal

Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise

Rachael Mason, Ruth C Meex, Prof Aaron Russell, Benedict J. Canny, Mr Matthew Watt

(2014), Vol. 9, pp. 1-9, PLoS one, San Francisco, CA, C1

journal

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Eduardo Dominguez, Andrea Galmozzi, Jae Won Chang, Ku-Lung Hsu, Joanna Pawlak, Weiwei Li, Cristina Godio, Jason Thomas, David Partida, Sherry Niessen, Paul E OBrien, Prof Aaron Russell, Matthew J Watt, Daniel K Nomura, Benjamin F Cravatt, Enrique Saez

(2014), Vol. 10, pp. 113-121, Nature Chemical Biology, New York, NY, C1

journal

High dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males

Mr Shaun Mason, Miss Raquel Baptista, Dr Paul Della Gatta, Dr Adel Yousif, Prof Aaron Russell, Dr Glenn Wadley

(2014), Vol. 77, pp. 130-138, Free Radical Biology and Medicine, Amsterdam, Neverlands, C1

journal
2013

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

Prof Aaron Russell, Shogo Wada, Lodovica Vergani, M. Benjamin Hock, Dr Severine Lamon, Dr Bertrand Leger, Takashi Ushida, Romain Cartoni, Dr Glenn Wadley, Peter Hespel, Anastasia Kralli, Gianni Soraru, Corrado Angelini, Takayuki Akimoto

(2013), Vol. 49, pp. 107-117, Neurobiology of disease, Maryland Heights, Mo., C1

journal

Ndrg2 is a PGC-1cx/ERRcx target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes

Dr Torie Foletta, Miss Erin Brown, Yoshitake Cho, Prof Rod Snow, Anastasia Kralli, Prof Aaron Russell

(2013), Vol. 1833, pp. 3112-3123, Biochimica et Biophysica Acta - Molecular Cell Research, Amsterdam, Netherlands, C1

journal

The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?

Dr Severine Lamon, Prof Aaron Russell

(2013), Vol. 4, pp. 1-9, Frontiers in physiology, Lausanne, Switzerland, C1-1

journal

MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease

Miss Evelyn Zacharewicz, Dr Severine Lamon, Prof Aaron Russell

(2013), Vol. 4, pp. 1-11, Frontiers in physiology, Lausanne, Switzerland, C1-1

journal

Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training

Dr Severine Lamon, Miss Marita Wallace, Miss Renae Stefanetti, Stine Rahbek, Mikkel H Vendelbo, Prof Aaron Russell, A/Prof Kristian Vissing

(2013), Vol. 465, pp. 1317-1325, Pfluegers Archiv: European journal of physiology, Berlin, Germany, C1-1

journal

Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway

A/Prof Kristian Vissing, Stine Rahbek, Dr Severine Lamon, Jean Farup, Miss Renae Stefanetti, Miss Marita Wallace, Mikkel H Vendelbo, Prof Aaron Russell

(2013), Vol. 591, pp. 3749-3763, Journal of physiology, London, Eng., C1-1

journal
2012

Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle

Prof Aaron Russell, Mihaela Crisan, Dr Bertrand Leger, M. Corselli, Andrew J. McAinch, Prof Paul O'Brien, A/Prof David Cameron-Smith, Bruno Peault, Louis Casteilla, Jean-Paul Giacobino

(2012), Vol. 36, pp. 155-158, International journal of obesity, London, England, C1

journal

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation

Saptarsi M. Haldar, Darwin Jeyaraj, Priti Anand, Han Zhu, Yuan Lu, Domenick A. Prosdocimo, Betty Eapen, Daiji Kawanami, Mitsuharu Okutsu, Leticia Brotto, Hisashi Fujioka, Janos Kerner, Mariana G. Rosca, Owen P. McGuinness, Prof Rod Snow, Prof Aaron Russell, Anthony N. Gerber, Xiaodong Bai, Zhen Yan, Thomas M. Nosek, Marco Brotto, Charles L. Hoppel, Mukesh K. Jain

(2012), Vol. 109, pp. 6739-6744, Proceedings of the National Academy of Sciences of the United States of America, Washington D.C., C1

journal

HSP72 preserves muscle function and slows progression of severe muscular dystrophy

Stefan M. Gehrig, Chris van der Poel, Timothy A. Sayer, Jonathan D. Schertzer, Darren C. Henstridge, Jarrod E. Church, Dr Severine Lamon, Prof Aaron Russell, Kay E. Davies, Prof Mark Febbraio, Prof Gordon Lynch

(2012), Vol. 484, pp. 394-398, Nature, London, U. K., C1

journal

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

Marta Derecka, Agnieszka Gornicka, Sergei B. Koralov, Karol Szczepanek, Magdalena Morgan, Vicisha Raje, Jennifer Sisler, Qifang Zhang, Dennis Otero, Joanna Cichy, Klaus Rajewsky, Kazuya Shimoda, Valeria Poli, Birgit Strobl, Sandra Pellegrini, Thurl E. Harris, Patrick Seale, Prof Aaron Russell, Andrew J. McAinch, Paul E. O\'Brien, Susanna R. Keller, Colleen M. Croniger, Tomasz Kordula, Andrew C. Larner

(2012), Vol. 16, pp. 814-824, Cell metabolism, Cambridge, Mass., C1

journal

The regulation and function of the striated muscle activator of rho signaling (STARS) protein

Miss Marita Wallace, Dr Severine Lamon, Prof Aaron Russell

(2012), Vol. 3, pp. 1-5, Frontiers in physiology, Lausanne, Switzerland, C1

journal

Wide-field assessment of the human corneal subbasal nerve plexus in diabetic neuropathy using a novel mapping technique

Katie Edwards, Nicola Pritchard, K Gosschalk, Dr Geoff Sampson, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2012), Vol. 31, pp. 1078-1082, Cornea, Philadelphia, PA, C1-1

journal

Visual sensitivity loss in the central 30° of visual field is associated with diabetic peripheral neuropathy

Dr Geoff Sampson, Ayda M Shahidi, Dimitrios Vagenas, Nicola Pritchard, Katie Edwards, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2012), Vol. 55, pp. 1179-1185, Diabetologia, Heidelberg, Germany, C1-1

journal

Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy

Ayda M Shahidi, Dr Geoff Sampson, Nicola Pritchard, Katie Edwards, Dimitrios Vagenas, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2012), Vol. 29, pp. 106-111, Diabetic medicine, Chichester, England, C1-1

journal

Optimal image sample size for corneal nerve morphometry

Dimitrios Vagenas, Nicola Pritchard, Katie Edwards, Ayda M Shahidi, Dr Geoff Sampson, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2012), Vol. 89, pp. 812-817, Optometry and vision science, Philadelphia, PA, C1-1

journal
2011

Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise

Miss Marita Wallace, M. Benjamin Hock, Bethany C. Hazen, Anastasia Kralli, Prof Rod Snow, Prof Aaron Russell

(2011), Vol. 589, pp. 2027-2039, Journal of physiology, London, England, C1

journal

Age-related changes in the molecular regulation of skeletal muscle mass

Prof Aaron Russell, Dr Bertrand Leger

(2011), pp. 207-221, Sarcopenia : age-related muscle wasting and weakness : mechanisms and treatments, Dordrecht, B1

chapter

Molecular mechanisms of inflammation : anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal

Mrs Lisa Parkinson, Prof Aaron Russell, Prof Russell Keast

(2011), Vol. 17, pp. 754-768, Current pharmaceutical design, Bussum, The Netherlands, C1

journal

Corneal markers of diabetic neuropathy

Nicola Pritchard, Katie Edwards, Ayda M Shahidi, Dr Geoff Sampson, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2011), Vol. 9, pp. 17-28, Ocular surface, Philadelphia, PA, C1-1

journal
2010

Maternal creatine supplementation from mid-pregnancy protects the diaphragm of the newborn spiny mouse from intrapartum hypoxia-induced damage

Mr David Cannata, Zoe Ireland, Dr Hayley Dickinson, Prof Rod Snow, Prof Aaron Russell, A/Prof Jan West, Prof David Walker

(2010), Vol. 68, pp. 393-398, Pediatric research, Baltimore, Md., C1

journal

Molecular regulation of skeletal muscle mass

Prof Aaron Russell

(2010), Vol. 37, pp. 378-384, Clinical and experimental pharmacology & physiology, Richmond, Vic., C1

journal

MicroRNAs in skeletal muscle : their role and regulation in development, disease and function

Ms Isabelle Guller, Prof Aaron Russell

(2010), Vol. 588, pp. 4075-4087, The Journal of Physiology, Oxford, England, C1

journal

Exploring retinal and functional markers of diabetic neuropathy

Ayda M Shahidi, Dr Geoff Sampson, Nicola Pritchard, Katie Edwards, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2010), Vol. 93, pp. 309-323, Clinical and experimental optometry, Chichester, England, C1-1

journal

Corneal sensitivity as an ophthalmic marker of diabetic neuropathy

Nicola Pritchard, Katie Edwards, Dimitrios Vagenas, Ayda M Shahidi, Dr Geoff Sampson, Prof Aaron Russell, Rayaz A Malik, Nathan Efron

(2010), Vol. 87, pp. 1003-1008, Optometry and vision science, Philadelphia, PA, C1-1

journal

Repeatability of measuring corneal subbasal nerve fiber length in individuals with type 2 diabetes

Nathan Efron, Katie Edwards, N Roper, Nicola Pritchard, Dr Geoff Sampson, Ayda M Shahidi, Dimitrios Vagenas, Prof Aaron Russell, J Graham, M A Dabbah, Rayaz A Malik

(2010), Vol. 36, pp. 245-248, Eye and contact lens, Philadelphia, PA, C1-1

journal
2009

Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more

Mr Clifford Liongue, Dr Craig Wright, Prof Aaron Russell, Prof Alister Ward

(2009), Vol. 41, pp. 2372-2375, International journal of biochemistry and cell biology, Amsterdam, The Netherlands, C1

journal

Regulation of STARS and its downstream target suggest a novel pathway involved in human skeletal hypertrophy and atrophy

Dr Severine Lamon, Miss Marita Wallace, Dr Bertrand Leger, Prof Aaron Russell

(2009), Vol. 587, pp. 1795-1803, Journal of physiology, Oxford, England, C1

journal

PPARy inhibits NF-B-dependent transcriptional activation in skeletal muscle

A. H. Remels, R. C J Langen, H. R Gosker, Prof Aaron Russell, F. Spaapen, J W Voncken, Patrick Schrauwen, A. M W J Schols

(2009), Vol. 297, pp. E174-E183, American journal of physiology- endocrinology and metabolism, Bethesda, Md., C1-1

journal

Atrogin-1, MuRF1, and FoXo, as well as phosphorylated GSK-3β and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients

Dr Bertrand Leger, Rosalba Senese, Abdul W. Al-Khodairy, Olivier Deriaz, Charles Gobelet, Jean-Paul Giacobino, Prof Aaron Russell

(2009), Vol. 40, pp. 69-78, Muscle and nerve, Hoboken, N.J., C1-1

journal

Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse

Zoe Ireland, Prof Aaron Russell, T Wallimann, David W Walker, Prof Rod Snow

(2009), Vol. 9, pp. 1-12, BMC developmental biology, London, England, C1

journal
2008

A reservoir of brown adipocyte progenitors in human skeletal muscle

Mihaela Crisan, Louis Casteilla, Lorenz Lehr, Mamen Carmona, Ariane Paolini-Giacobino, Solomon Yap, Bin Sun, Dr Bertrand Leger, Alison Logar, Luc Penicaud, Patrick Schrauwen, A/Prof David Cameron-Smith, Prof Aaron Russell, Bruno Peault, Jean-Paul Giacobino

(2008), Vol. 26, pp. 2425-2433, Stem cells : the international journal of cell differentiation and proliferation, Dayton, Oh., C1

journal

Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation

Dr Bertrand Leger, Wim Derave, Katrien DeBock, Peter Hespel, Prof Aaron Russell

(2008), Vol. 11, pp. 163-175, Rejuvenation research, New Rochelle, N.Y., C1

journal

Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase

Serge Summermatter, Davide Mainieri, Prof Aaron Russell, Jean-Pierre Montani, Josiane Seydoux, Antony J. Buchala, G Solinas, Abdul G Dulloo

(2008), Vol. 22, pp. 774-785, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1

journal
2007

Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants

Lodovica Vergani, Adriana Malena, Patrizia Sabatelli, Emanuele Loro, Lucia Cavallini, Paolo Magalhaes, Lucia Valente, Federica Bragantini, Franco Carrara, Dr Bertrand Leger, Joanna Poulton, Prof Aaron Russell, Ian P. Holt

(2007), Vol. 130, pp. 2715-2724, Brain: a journal of neurology, Oxford, England, C1

journal

Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene (PGC1A) during weight loss is related to insulin sensitivity but not to energy expenditure

Giacomo Gastaldi, Prof Aaron Russell, Alain Golay, Jean-Paul Giacobino, F Habicht, V Barthassat, Patrick Muzzin, Elisabetta Bobbioni-Harsch

(2007), Vol. 50, pp. 2348-2355, Diabetologia: clinical and experimental diabetes and metabolism, Berlin , Germany, C1

journal

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease

Marieve Doucet, Prof Aaron Russell, Dr Bertrand Leger, Richard Debigare, Denis R. Joanisse, Marc-Andre Caron, Pierre LeBlanc, Francois Maltais

(2007), Vol. 176, pp. 261-269, American journal of respiratory and critical care medicine, New York, N. Y., C1

journal

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARß/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus

Marco Mensink, Matthijs K. C. Hesselink, Prof Aaron Russell, Gert Schaart, Jean-Pierre Sels, Patrick Schrauwen

(2007), Vol. 31, pp. 1301-1310, International journal of obesity, London, England, C1

journal

Slow component of VO2 during level and uphill treadmill running : relationship to aerobic fitness in endurance runners

V. M. Reis, L. Guidetti, J. A. Duarte, A. Ascensao, A. J. Silva, J. E. Sampaio, Prof Aaron Russell, C. Baldari

(2007), Vol. 47, pp. 135-140, Journal of sports medicine and physical fitness, Torino, Italy, C1-1

journal
2006

Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1

Dr Bertrand Leger, Lodovica Vergani, Gianni Soraru, Peter Hespel, Wim Derave, Charles Gobelet, Carla D`Ascenzio, Corrado Angelini, Prof Aaron Russell

(2006), Vol. 20, pp. 583-585, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids

Joris Hoeks, Matthijs K. C. Hesselink, Prof Aaron Russell, Marco Mensink, W.H.M. Saris, Ronald Mensink, Patrick Schrauwen

(2006), Vol. 49, pp. 2419-2426, Diabetologia, Heidelberg, Germany, C1-1

journal

A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

Davide Mainieri, Serge Summermatter, Josiane Seydoux, Jean-Pierre Montani, Sandro Rusconi, Prof Aaron Russell, Olivier Boss, Antony J. Buchala, Abdul G Dulloo

(2006), Vol. 20, pp. 1157-1170, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

Reduced Skeletal Muscle Uncoupling Protein-3 Content in Prediabetic Subjects and Type 2 Diabetic Patients: Restoration by Rosiglitazone Treatment

Patrick Schrauwen, Marco Mensink, Gert Schaart, Esther Moonen-Kornips, Jean-Pierre Sels, Ellen Blaak, Prof Aaron Russell, Matthijs K. C. Hesselink

(2006), Vol. 91, pp. 1520-1525, Journal of clinical endocrinology and metabolism, Chevy Chase, Md., C1-1

journal

Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy

Dr Bertrand Leger, Romain Cartoni, Manu Praz, Dr Severine Lamon, Olivier Deriaz, Antoinette Crettenand, Charles Gobelet, Paul Rohmer, Michel Konzelmann, Francois Luthi, Prof Aaron Russell

(2006), Vol. 576, pp. 923-933, Journal of physiology, West Sussex, England, C1-1

journal
2005

PGC-1α and exercise: important partners in combating insulin resistance

Prof Aaron Russell

(2005), Vol. 1, pp. 175-181, Current diabetes reviews, Bussum, Netherlands, C1-1

journal

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes.

Mr Anthony Civitarese, Matthijs K. C. Hesselink, Prof Aaron Russell, Eric Ravussin, Patrick Schrauwen

(2005), Vol. 289, pp. 1023-1029, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1-1

journal

Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans

Katrien DeBock, Erik Richter, Prof Aaron Russell, B. O. Eijnde, W Derave, M Ramaekers, E Konickz, Dr Bertrand Leger, J Verhaeghe, Peter Hespel

(2005), Vol. 564, pp. 649-660, Journal of applied physiology, Bethesda, Md., C1-1

journal

Effect of 2 weeks of endurance training on uncoupling protein3 content in untrained human subjects

Patrick Schrauwen, Prof Aaron Russell, Esther Moonen-Kornips, N Boon, Matthijs K. C. Hesselink

(2005), Vol. 183, pp. 273-280, Acta physiologica, Oxford, England, C1-1

journal

Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat. A link between catch-up growth and later metabolic syndrome.

Phillipe Cettour-Rose, Samec Sonia, Prof Aaron Russell, Serge Summermatter, Davide Mainieri, Claudia Carrillo-Theander, Jean-Pierre Montani, Josiane Seydoux, Francoise Rohner-Jeanrenaud, Abdul G Dulloo

(2005), Vol. 54, pp. 751-756, Diabetes, New York, N.Y., C1-1

journal

Mitofusions1/2 and ERRα expression are increased in human skeletal muscle after physical exercise.

Romain Cartoni, Dr Bertrand Leger, M. Benjamin Hock, Manu Praz, Antoinette Crettenand, Sara Pich, Jean-Luc Ziltener, Francois Luthi, Olivier Deriaz, Antonio Zorzano, Charles Gobelet, Anastasia Kralli, Prof Aaron Russell

(2005), Vol. 567, pp. 349-358, Journal of physiology, London, England, C1-1

journal

Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise

Prof Aaron Russell, Matthijs K. C. Hesselink, Prof Sing Lo, Patrick Schrauwen

(2005), Vol. 19, pp. 986-988, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal
2004

Lipotoxicity: the obese and endurance-trained paradox

Prof Aaron Russell

(2004), Vol. 28, pp. S66-S71, International journal of obesity, London, England, C1-1

journal

Antioxidant defences and homeostasis of reactive oxygen species in different human mitochondrial DNA-depleted cell lines

Lodovica Vergani, Maura Floreani, Prof Aaron Russell, Mara Ceccon, Eleonora Napoli, Anna Cabrelle, Lucia Valente, Federica Bragantini, Dr Bertrand Leger, Federica Dabbeni-Sala

(2004), Vol. 271, pp. 3646-3656, European journal of biochemistry, Oxford, England, C1-1

journal

COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers.

Prof Aaron Russell, Emmanuel Somm, Richard Debigare, Oliver Hartley, Denis Richard, Gastaldi Giacomo, Astrid Melotti, Annie Michaud, Jean-Paul Giacobino, Patrick Muzzin, Pierre LeBlanc, Francois Maltais

(2004), Vol. 24, pp. 332-339, Journal of cardiopulmonary rehabilitation, Philadelphia, Pa., C1-1

journal
2003

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-[gamma] coactivator-1 and peroxisome proliferator-activated receptor-[alpha] in skeletal muscle

Prof Aaron Russell, Jonas Feilchenfeldt, Sylvia Schreiber, Manu Praz, Antoinette Crettenand, Charles Gobelet, Christoph Meier, David Bell, Anastasia Kralli, Jean-Paul Giacobino, Olivier Deriaz

(2003), Vol. 52, pp. 2874-2881, Diabetes, New York, N.Y., C1-1

journal

UCP3 protein regulation in human skeletal muscle fibre types I, IIa andIIx is dependent on exercise intensity.

Prof Aaron Russell, Emmanuel Somm, Manu Praz, Antoinette Crettenand, Oliver Hartley, Astrid Melotti, Jean-Paul Giacobino, Patrick Muzzin, Charles Gobelet, Olivier Deriaz

(2003), Vol. 550, pp. 855-861, Journal of physiology, London, England, C1-1

journal

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Prof Aaron Russell, Giacomo Gastaldi, Elisabetta Bobbioni-Harsch, Patrizia Arboit, Charles Gobelet, Olivier Deriaz, Alain Golay, Joseph L Witztum, Jean-Paul Giacobino

(2003), Vol. 551, pp. 104-106, FEBS letter, Amsterdam, The Netherlands, C1-1

journal

UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects

Prof Aaron Russell, Dr Glenn Wadley, Matthijs K. C. Hesselink, Gert Schaart, Prof Sing Lo, Dr Bertrand Leger, Dr Andrew Garnham, Esther Kornips, A/Prof David Cameron-Smith, Jean-Paul Giacobino, Patrick Muzzin, Prof Rod Snow, Patrick Schrauwen

(2003), Vol. 445, pp. 563-569, Pfluegers Archiv : European journal of physiology, Berlin, Germany, C1

journal

Decreased fatty acit Â-oxidation in riboflavin-responsive, multiple acylocoenzyme a dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3

Prof Aaron Russell, Patrick Schrauwen, Emmanuel Somm, Giacomo Gastaldi, Matthijs K. C. Hesselink, Gert Schaart, Esther Kornips, Prof Sing Lo, Daniela Bufano, Jean-Paul Giacobino, Patrick Muzzin, Mara Ceccon, Corrado Angelini, Lodovica Vergani

(2003), Vol. 88, pp. 5921-5926, Journal of clinical endocrinology and metabolism, Chevy Chase, MD, C1-1

journal
2002

Skeletal muscle htererogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPARĂ and key enzymes of lipid oxidation

S Samec, Josiane Seydoux, Prof Aaron Russell, Jean-Pierre Montani, Abdul G Dulloo

(2002), Vol. 445, pp. 80-86, Pfluegers Archiv: European Journal of Physiology, Berlin, Germany, C1-1

journal

Effect of accurate exercise on uncoupling protein3 is a fat metabolism-mediated effect

Patrick Schrauwen, Matthijs K. C. Hesselink, Ilonca Vaartjes, Esther Kornips, W.H.M. Saris, Jean-Paul Giacobino, Prof Aaron Russell

(2002), Vol. 282, pp. E11-E17, American journal of physiology: endocrinology and metabolism, Oxford, England, C1-1

journal

Expression of uncoupling protein-3 subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its moduclation by fasting

Maria Jimenez, Cedric Yvon, Lorenz Lehr, Dr Bertrand Leger, Patrick Keller, Prof Aaron Russell, Francoise Kuhne, Pierre Flandin, Jean-Paul Giacobino, Patrick Muzzin

(2002), Vol. 269, pp. 2878-2884, The FEBS journal, Oxford, England, C1-1

journal

ß1/ß2/ß3-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting

Maria Jimenez, Dr Bertrand Leger, Kriss Canola, Lorenz Lehr, Patrizia Arboit, Josiane Seydoux, Prof Aaron Russell, Jean-Paul Giacobino, Patrick Muzzin, Frederic Prietner

(2002), Vol. 530, pp. 37-40, FEBS letters, Amsterdam, The Netherlands, C1-1

journal

Cycling at 120 when compared to 80 rev/min increases the accumulated oxygen deficit but does not affect the precision of its calculation

Prof Aaron Russell, Dr Peter Le Rossignol, Prof Rod Snow, Prof Sing Lo

(2002), Vol. 5, pp. 32-38, Journal of exercise physiology online, Duluth, Minn., C1

journal

Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity

Prof Aaron Russell, Dr Glenn Wadley, Prof Rod Snow, Jean-Paul Giacobino, Patrick Muzzin, Dr Andrew Garnham, A/Prof David Cameron-Smith

(2002), Vol. 26, pp. 157-164, International journal of obesity: and related metabolic disorders, Hampshire, England, C1

journal

Improving the precision of the accumulated oxygen deficit using VO2-power regression points from below and above the lactate threshold

Prof Aaron Russell, Dr Peter Le Rossignol, Prof Rod Snow, Prof Sing Lo

(2002), Vol. 5, pp. 23-31, Journal of Exercise Physiology Online, Duluth Minn, C1

journal