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Prof Alex Gentle

STAFF PROFILE

Position

Associate Head Of School (T & L)

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Bachelor of Science, City University London, 1994
Doctor of Philosophy, University of Wales, 1999
Graduate Certificate in University Teaching, University of Melbourne, 2007
Postgraduate Certificate in Ocular Therapeutics, University of Melbourne, 2011

Contact

alex.gentle@deakin.edu.au
+61 3 522 72550

Affiliations

Fellow of the College of Optometrists

Fellow of the Australian College of Optometry

Fellow of the American Academy of Optometry

Member of the Association for Research in Vision and Ophthalmology

Publications

Filter by

2017

Reduced scleral TIMP-2 expression is associated with myopia development: TIMP-2 supplementation stabilizes scleral biomarkers of myopia and limits myopia development

H-H Liu, M Kenning, A Jobling, N McBrien, A Gentle

(2017), Vol. 58, pp. 1971-1981, Investigative ophthalmology and visual science, Rockville, Md., C1

journal
2011

The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action

N McBrien, B Arumugam, A Gentle, A Chow, S Sahebjada

(2011), Vol. 31, pp. 529-539, Ophthalmic & physiological optics, Oxford, Eng., C1-1

journal

Myopia : why study the mechanisms of myopia? Novel approaches to risk factors Signaling eye growth- how could basic biology be translated into clinical insights? Where are genetic and proteomic approaches leading? How does visual function contribute to and interact with ametropia? Does eye shape matter? Why ametropia at all?

E Tarutta, W Chua, T Young, E Goldschmidt, S Saw, K Rose, E Smith, D Mutti, R Ashby, R Stone, C Wildsoet, H Howland, A Fischer, W Stell, A Reichenbach, M Frost, A Gentle, X Zhu, J Summers-Rada, V Barathi, L Jiang, S McFadden, J Guggenheim, C Hammond, R Schippert, C To, J Gwiazda, S Marcos, M Collins, W Charman, P Artal, J Tabernero, D Atchison, A Seidemann, D Uttenweiler, D Troilo, T Norton, J Wallman

(2011), Vol. 88, pp. 404-447, Optometry and vision science, Sydney, N.S.W., C1-1

journal
2010

Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development

H Liu, A Gentle, A Jobling, N McBrien

(2010), Vol. 51, pp. 2865-2871, Investigative ophthalmology & visual science, Rockville, Md., C1-1

journal
2009

Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia

N McBrien, A Jobling, H Truong, C Cottriall, A Gentle

(2009), Vol. 15, pp. 464-475, Molecular vision: Biology and genetics in vision research, Atlanta, Ga., C1-1

journal

Biomechanics of the sclera in myopia: Extracellular and cellular factors

N McBrien, A Jobling, A Gentle

(2009), Vol. 86, pp. 23-30, Optometry and vision science, Sydney, N.S.W., C1-1

journal

Myopia: Recent advances in molecular studies; Prevalence, progression and risk factors; Emmetropization; Therapies; Optical links; Peripheral refraction; Sclera and ocular growth; Signalling cascades; and animal models.

N McBrien, T Young, C Pang, C Hammond, P Baird, S Saw, I Morgan, D Mutti, K Rose, J Wallman, A Gentle, C Wildsoet, J Gwiazda, K Schmid, E Smith, D Troilo, J Summers-Rada, T Norton, F Schaeffel, P Megaw, R Beuerman, S McFadden

(2009), Vol. 86, pp. 45-66, Optometry and vision science, Sydney, N.S.W., C1-1

journal

Retinal and choroidal TGF-? in the tree shrew model of myopia: Isoform expression, activation and effects on function

A Jobling, R Wan, A Gentle, B Bui, N McBrien

(2009), Vol. 88, pp. 458-466, Experimental eye research, Amsterdam, The Netherlands, C1-1

journal
2008

Regulation of scleral cell contraction by transforming growth factor-? and stress competing roles in myopic growth

A Jobling, A Gentle, R Metlapally, B McGowan, N McBrien

(2008), Vol. 284, pp. 2072-2079, Journal of biological chemistry, Manchester, Eng., C1-1

journal
2006

Altered visual sensitivity in axial high myopia: a local postreceptoral phenomenon?

A Jaworski, A Gentle, A Zele, A Vingrys, N McBrien

(2006), Vol. 47, pp. 3695-3702, Investigative ophthalmology and visual science, Rockville, Md., C1-1

journal

Characterization of the integrin receptor subunit profile in the mammalian sclera

R Metlapally, A Jobling, A Gentle, N McBrien

(2006), Vol. 12, pp. 725-734, Molecular vision, Atlanta, Ga., C1-1

journal

Expression of collagen-binding integrin receptors in the mammalian sclera and their regulation during the development of myopia

N McBrien, R Metlapally, A Jobling, A Gentle

(2006), Vol. 47, pp. 4674-4682, Investigative ophthalmology and visual science, Rockville, Md., C1-1

journal
2004

Muscarinic antagonist control of myopia: a molecular search for the M1 receptor in chick

G Yin, A Gentle, N McBrien

(2004), Vol. 10, pp. 787-793, Molecular vision, Atlanta, Ga., C1-1

journal

Isoform-specific changes in scleral transforming growth factor-beta expression and the regulation of collagen synthesis during myopia progression

A Jobling, M Nguyen, A Gentle, N McBrien

(2004), Vol. 279, pp. 18121-18126, Journal of biological chemistry, Rockville, Md., C1-1

journal
2003

Role of the sclera in the development and pathological complications of myopia

N McBrien, A Gentle

(2003), Vol. 22, pp. 307-338, Progress in retinal and eye research, Kidlington, Eng., C1-1

journal

Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia

A Gentle, Y Liu, J Martin, G Conti, N McBrien

(2003), Vol. 278, pp. 16587-16594, Journal of biological chemistry, Bethesda, Md., C1-1

journal
2002

Retinoscleral control of scleral remodelling in refractive development: a role for endogenous FGF-2?

A Gentle, N McBrien

(2002), Vol. 18, pp. 344-348, Cytokine, Amsterdam, The Netherlands, C1-1

journal

Pirenzepine affects scleral metabolic changes in myopia through a non-toxic mechanism

H-T Truong, C Cottriall, A Gentle, N McBrien

(2002), Vol. 74, pp. 103-111, Experimental eye research, Amsterdam, The Netherlands, C1-1

journal
2001

Glycosaminoglycan synthesis in the separate layers of the chick sclera during myopic eye growth: comparison with mammals

A Gentle, H Truong, N McBrien

(2001), Vol. 23, pp. 179-184, Current eye research, Abingdon, Eng., C1-1

journal

High-resolution semi-quantitative real-time PCR without the use of a standard curve

A Gentle, F Anastasopoulos, N McBrien

(2001), Vol. 31, pp. 502-508, Biotechniques, Boca Raton, Fla., C1-1

journal

Structural and ultrastructural changes to the sclera in a mammalian model of high myopia

N McBrien, L Cornell, A Gentle

(2001), Vol. 42, pp. 2179-2187, Investigative ophthalmology & visual science, Rockville, Md., C1-1

journal

The role of visual information in the control of scleral matrix biology in myopia

N McBrien, A Gentle

(2001), Vol. 23, pp. 313-319, Current eye research, Abingdon, Eng., C1-1

journal
2000

Scleral remodeling during the development of and recovery from axial myopia in the tree shrew

N McBrien, P Lawlor, A Gentle

(2000), Vol. 41, pp. 3713-3719, Investigative opthalmology & visual science, Rockville, Md., C1-1

journal
1999

Modulation of scleral DNA synthesis in development of and recovery from induced axial myopia in the tree shrew

A Gentle, N McBrien

(1999), Vol. 68, pp. 155-163, Experimental eye research, London, Eng., C1-1

journal

Optical correction of induced axial myopia in the tree shrew: implications for emmetropization

N McBrien, A Gentle, C Cottriall

(1999), Vol. 76, pp. 419-427, Optometry and vision science, Orlando, Fla., C1-1

journal

Funded Projects at Deakin

No Funded Projects at Deakin found

Supervisions

No completed student supervisions to report