A/Prof. Clinton Bruce

STAFF PROFILE

Position

ARC Future Fellow

Faculty

Faculty of Health

Department

School of Exercise & Nut. Sci.

Campus

Melbourne Burwood Campus

Qualifications

Doctor of Philosophy, Royal Melb Inst. of Technology, 2003

Contact

clinton.bruce@deakin.edu.au
+61 3 924 46684

Biography

Dr Bruce received his PhD from RMIT University in 2003 and completed postdoctoral appointments at the University of Guelph, Canada, the Garvan Institute of Medical Research and the Baker IDI Heart and Diabetes Institute. He established an independent laboratory in the Department of Physiology at Monash University in 2012 prior to taking up an academic appointment at Deakin University in 2014. 

Read more on Clinton's profile

Research interests

Dr Bruce’s research is focussed on understanding the regulation of glucose metabolism in skeletal muscle and liver in health and disease. He is particularly interested in identifying mechanisms underlying the development of glucose intolerance and insulin resistance.  He also has an interest in identifying the role of lipids in regulating skeletal muscle function. His research involves the use of stable isotope methodology and GC-MS based metabolomics to measure glucose and lipid fluxes, protein synthesis and mitochondrial biogenesis.

Affiliations

Member of the Australian Physiological Society (AuPS), the Australian Diabetes Society (ADS) and the Australian and New Zealand Metabolomics Network (ANZMN)

Units taught

Unit chair HSN751 Human Nutrition Research project Part B

Unit chair HSN703 Diet and Disease

Unit chair HSN753 Research Practice in Human Nutrition

Knowledge areas

Glucose metabolism, lipid metabolism, insulin resistance, type 2 diabetes, metabolomics, stable isotopes, muscle physiology

Expertise

Insulin resistance, glucose metabolism, hepatic glucose production, skeletal muscle physiology, lipid metabolism, tracers in metabolic research

Awards

2013-2014 Monash Researcher Accelerator Program
2013 Australian Diabetes Society annual meeting Pincus Taft Young Investigator awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).
2012 Australian Diabetes Society annual meeting best basic science poster awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).
2010-2013 NHMRC Career Development Award
2005-2009 NHMRC Peter Doherty Postdoctoral Fellowship
2000-2003 Australian Postgraduate Research Award

Projects

Mechanisms of glucose intolerance and insulin resistance.

The role of membrane lipids in regulating skeletal muscle physiology.

Publications

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2017

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

journal

Creatine biosynthesis and transport by the term human placenta

S Ellery, P Della Gatta, C Bruce, G Kowalski, M Davies-Tuck, J Mockler, P Murthi, D Walker, R Snow, H Dickinson

(2017), Vol. 52, pp. 86-93, Placenta, Amsterdam, The Netherlands, C1

journal

Does maternal-fetal transfer of creatine occur in pregnant sheep?

S Baharom, R De Matteo, S Ellery, P Della Gatta, C Bruce, G Kowalski, N Hale, H Dickinson, R Harding, D Walker, R Snow

(2017), Vol. 313, pp. E75-E83, American journal of physiology, endocrinology and metabolism, Bethesda, Md., C1

journal

Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice

G Kowalski, M Kraakman, S Mason, A Murphy, C Bruce

(2017), Vol. 233, pp. 269-279, Journal of endocrinology, Bristol, Eng., C1

journal

Effects of breaking up sitting on adolescents' postprandial glucose after consuming meals varying in energy: a cross-over randomised trial

E Fletcher, J Salmon, S McNaughton, L Orellana, G Wadley, C Bruce, P Dempsey, K Lacy, D Dunstan

(2017), Journal of science and medicine in sport, Amsterdam, The Netherlands, C1

journal

The effect of ingested glucose dose on the suppression of endogenous glucose production in humans

G Kowalski, S Moore, S Hamley, A Selathurai, C Bruce

(2017), Vol. 66, pp. 2400-2406, Diabetes, Arlington County, Va., C1

journal

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway.

Aowen Zhuang, Felicia Yap, Clinton Bruce, Chris Leung, Manuel Plan, Mitchell Sullivan, Chandana Herath, Domenica McCarthy, Karly Sourris, Phillip Kantharidis, Melinda Coughlan, Mark Febbraio, Mark Hodson, Matthew Watt, Peter Angus, Benjamin Schulz, Josephine Forbes

(2017), Vol. 7, pp. 12292-, Sci Rep, England, C1

journal
2016

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

J Wentworth, G Naselli, K Ngui, G Smyth, R Liu, P O'Brien, C Bruce, J Weir, M Cinel, P Meikle, L Harrison

(2016), Vol. 40, pp. 706-713, International journal of obesity, London, Eng., C1

journal

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

G Lancaster, H Kammoun, M Kraakman, G Kowalski, C Bruce, M Febbraio

(2016), Vol. 7, pp. 1-10, Nature communications, London, Eng., C1

journal

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis

G Kowalski, S Hamley, A Selathurai, J Kloehn, D De Souza, S O?Callaghan, B Nijagal, D Tull, M McConville, C Bruce

(2016), Vol. 6, pp. 1-10, Scientific reports, London, Eng., C1

journal

?-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Müller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschöp, M Watt, I Clarke, C Roth, K Grove, M Cowley

(2016), Vol. 5, pp. 807-822, Molecular metabolism, Amsterdam, The Netherlands, C1

journal

Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell reports, New York, N.Y., C1

journal

Analysis of mammalian cell proliferation and macromolecule synthesis using deuterated water and gas chromatography-mass spectrometry

V Foletta, M Palmieri, J Kloehn, S Mason, S Previs, M McConville, O Sieber, C Bruce, G Kowalski

(2016), Vol. 6, pp. 1-19, Metabolites, Basel, Switzerland, C1

journal

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

R Lee-Young, N Hoffman, K Murphy, D Henstridge, D Samocha-Bonet, A Siebel, P Iliades, B Zivanovic, Y Hong, T Colgan, M Kraakman, C Bruce, P Gregorevic, G McConell, G Lynch, G Drummond, B Kingwell, J Greenfield, M Febbraio

(2016), Vol. 5, pp. 1083-1091, Molecular Metabolism, Amsterdam, The Netherlands, C1

journal
2015

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Greg Kowalski, Joachim Kloehn, Micah Burch, Ahrathy Selathurai, Steven Hamley, Stéphanie Bayol, Séverine Lamon, Matthew Watt, Robert Lee-Young, Malcolm McConville, C Bruce

(2015), Vol. 1851, pp. 210-219, Biochimica et Biophysica Acta (BBA)- molecular and cell biology of lipids, Amsterdam, Netherlands, C1

journal

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

M Kraakman, H Kammoun, T Allen, V Deswaerte, D Henstridge, E Estevez, V Matthews, B Neill, D White, A Murphy, L Peijs, C Yang, S Risis, C Bruce, X-J Du, A Bobik, R Lee-Young, B Kingwell, A Vasanthakumar, W Shi, A Kallies, G Lancaster, S Rose-John, M Febbraio

(2015), Vol. 21, pp. 403-416, Cell metabolism, Amsterdam, The Netherlands, C1-1

journal

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1

journal

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse.

G Kowalski, D De Souza, M Burch, S Hamley, J Kloehn, A Selathurai, D Tull, S O'Callaghan, M McConville, C Bruce

(2015), Vol. 462, pp. 27-32, Biochemical biophysical research communications, Amsterdam, The Netherlands, C1

journal

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

journal

In vivo cardiac glucose metabolism in the high-fat fed mouse: comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach

G Kowalski, D De Souza, S Risis, M Burch, S Hamley, J Kloehn, A Selathurai, R Lee-Young, D Tull, S O'Callaghan, M McConville, C Bruce

(2015), Vol. 463, pp. 818-824, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

P Sepulveda, S Lamon, A Hagg, R Thomson, C Winbanks, H Qian, C Bruce, A Russell, P Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

journal
2014

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

Darren Henstridge, Clinton Bruce, Brian Drew, Kálmán Tory, Attila Kolonics, Emma Estevez, Jason Chung, Nadine Watson, Timothy Gardner, Robert Lee-Young, others

(2014), Vol. 63, pp. 1881-1894, Diabetes, C1

journal

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

Nigel Turner, Gregory Cooney, Edward Kraegen, Clinton Bruce

(2014), Vol. 220, pp. T61-T79, Journal of Endocrinology, C1-1

journal

Growing healthy muscles to optimise metabolic health into adult life

S Bayol, C Bruce, G Wadley

(2014), Vol. 5, pp. 420-434, Journal of developmental origins of health and disease, Cambridge, United Kingdom, C1

journal

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

G Kowalski, C Bruce

(2014), Vol. 307, pp. E859-E871, American journal of physiology-endocrinology and metabolism, Bethesda, MD, C1

journal

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Rachael Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg Kowalski, Nancy Mokbel, Peter Meikle, Clinton Bruce, Matthew Watt

(2014), Vol. 3, pp. 652-663, Molecular metabolism, Amsterdam, Netherlands, C1-1

journal
2013

Plasma sphingosine-1-phosphate is elevated in obesity

G Kowalski, A Carey, A Selathurai, B Kingwell, C Bruce

(2013), Vol. 8, pp. 1-7, PloS one, San Francisco, Calif., C1-1

journal

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

B Lindegaard, V Matthews, C Brandt, P Hojman, T Allen, E Estevez, M Watt, C Bruce, O Mortensen, S Syberg, C Rudnicka, J Abildgaard, H Pilegaard, J Hidalgo, S Ditlevsen, T Alsted, A Madsen, B Pedersen, M Febbraio

(2013), Vol. 62, pp. 3064-3074, Diabetes, Alexandria, Vir., C1-1

journal

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm

S Miura, Y Kai, M Tadaishi, Y Tokutake, K Sakamoto, C Bruce, M Febbraio, K Kita, S Chohnan, O Ezaki

(2013), Vol. 305, pp. E213-E229, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

journal

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Nigel Turner, G Kowalski, S Leslie, Steve Risis, Christine Yang, R Lee-Young, J Babb, P Meikle, G Lancaster, D Henstridge, others

(2013), Vol. 56, pp. 1638-1648, Diabetologia, C1-1

journal

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

James Boon, Andrew Hoy, Romana Stark, Russell Brown, Ruth Meex, Darren Henstridge, Simon Schenk, Peter Meikle, Jeffrey Horowitz, Bronwyn Kingwell, others

(2013), Vol. 62, pp. 401-410, Diabetes, C1-1

journal
2012

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

Clinton Bruce, Steve Risis, Joanne Babb, Christine Yang, Robert Lee-Young, Darren Henstridge, Mark Febbraio

(2012), Vol. 154, pp. 65-76, Endocrinology, C1-1

journal

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

Clinton Bruce, Steve Risis, Joanne Babb, Christine Yang, Greg Kowalski, Ahrathy Selathurai, Robert Lee-Young, Jacquelyn Weir, Kazuaki Yoshioka, Yoh Takuwa, others

(2012), Vol. 61, pp. 3148-3155, Diabetes, C1-1

journal

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

D Henstridge, C Bruce, C Pang, G Lancaster, T Allen, Emma Estevez, T Gardner, J Weir, P Meikle, K Lam, others

(2012), Vol. 55, pp. 2769-2778, Diabetologia, C1-1

journal

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide

M Watt, A Barnett, C Bruce, S Schenk, J Horowitz, A Hoy

(2012), Vol. 55, pp. 2741-2746, Diabetologia, C1-1

journal

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes

Melissa Barber, Steve Risis, Christine Yang, Peter Meikle, Margaret Staples, Mark Febbraio, Clinton Bruce

(2012), Vol. 7, pp. e41456-e41456, PloS one, C1-1

journal

IkappaB kinase beta (IKKbeta) does not mediate feedback inhibition of the insulin signalling cascade

I Graeme, Skiba Beata, Yang Christine, T Hayley, G Katherine, R Clinton, W Gordon, R Peter, Karin Michael, A Mark

(2012), Vol. 442, pp. 723-732, Biochemical Journal, C1-1

journal
2011

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation

Xiao-Ming Gao, Yang Liu, David White, Yidan Su, Brian Drew, Clinton Bruce, Helen Kiriazis, Qi Xu, Nicole Jennings, Alex Bobik, others

(2011), Vol. 50, pp. 991-999, Journal of molecular and cellular cardiology, C1-1

journal

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

G Kowalski, H Nicholls, S Risis, N Watson, Peter Kanellakis, C Bruce, Alex Bobik, G Lancaster, M Febbraio

(2011), Vol. 54, pp. 888-899, Diabetologia, C1-1

journal

Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet-Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation

Andrew Hoy, Clinton Bruce, Sarah Turpin, Alexander Morris, Mark Febbraio, Matthew Watt

(2011), Vol. 152, pp. 48-58, Endocrinology, C1-1

journal
2010

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

Todd Mitchell, Nigel Turner, Paul Else, Anthony Hulbert, John Hawley, Jong Lee, Clinton Bruce, Stephen Blanksby

(2010), Vol. 11, pp. 3954-3964, International journal of molecular sciences, C1-1

journal

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

V Matthews, T Allen, S Risis, M Chan, D Henstridge, N Watson, L Zaffino, J Babb, James Boon, P Meikle, others

(2010), Vol. 53, pp. 2431-2441, Diabetologia, C1-1

journal

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness (Molecular Endocrinology (2008) 22, (1200-1212) DOI: 10.1210/me.2007-0485) erratum

M Watt, D Van, L Castelli, C Bruce, A Hoy, E Kraegen, L Macaulay, B Kemp

(2010), Vol. 24, pp. 1308-1308, Molecular endocrinology, Washington, DC, C1-1

journal
2009

Reactive oxygen species enhance insulin sensitivity

Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Clinton Bruce, Benjamin Shields, Beata Skiba, Lisa Ooms, others

(2009), Vol. 10, pp. 260-272, Cell metabolism, C1-1

journal

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

V Matthews, M-B Åström, M Chan, C Bruce, K Krabbe, Oja Prelovsek, Thorbjörn Åkerström, C Yfanti, C Broholm, O Mortensen, others

(2009), Vol. 52, pp. 1409-1418, Diabetologia, C1-1

journal

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

Andrew Hoy, Amanda Brandon, Nigel Turner, Matthew Watt, Clinton Bruce, Gregory Cooney, Edward Kraegen

(2009), Vol. 297, pp. E67-E75, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

Clinton Bruce, Andrew Hoy, Nigel Turner, Matthew Watt, Tamara Allen, Kevin Carpenter, Gregory Cooney, Mark Febbraio, Edward Kraegen

(2009), Vol. 58, pp. 550-558, Diabetes, C1-1

journal

?2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise

Shinji Miura, Yuko Kai, Yasutomi Kamei, Clinton Bruce, Naoto Kubota, Mark Febbraio, Takashi Kadowaki, Osamu Ezaki

(2009), Vol. 296, pp. E47-E55, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal
2008

AMP-activated protein kinase and muscle insulin resistance.

Edward Kraegen, Clinton Bruce, Bronwyn Hegarty, Ji-Ming Ye, Nigel Turner, G Cooney

(2008), Vol. 14, pp. 4658-4672, Frontiers in bioscience: a journal and virtual library, C1-1

journal

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPAR? and UCP2 expression in rats

Anna Holmes, Jose Mesa, Bronwyn Neill, Jason Chung, Andrew Carey, Gregory Steinberg, Bruce Kemp, Robert Southgate, Graeme Lancaster, Clinton Bruce, others

(2008), Vol. 198, pp. 367-374, Journal of Endocrinology, C1-1

journal

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness

Matthew Watt, Bryce Van Denderen, Laura Castelli, Clinton Bruce, Andrew Hoy, Edward Kraegen, Lance Macaulay, Bruce Kemp

(2008), Vol. 22, pp. 1200-1212, Molecular Endocrinology, C1-1

journal

HSP72 protects against obesity-induced insulin resistance

Jason Chung, Anh-Khoi Nguyen, Darren Henstridge, Anna Holmes, M Chan, Jose Mesa, Graeme Lancaster, Robert Southgate, Clinton Bruce, Stephen Duffy, others

(2008), Vol. 105, pp. 1739-1744, Proceedings of the National Academy of Sciences, C1-1

journal
2007

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle Evidence Against a Role for Reduced Fatty Acid Oxidation in Lipid-Induced Insulin Resistance in Rodents

Nigel Turner, Clinton Bruce, Susan Beale, Kyle Hoehn, Trina So, Michael Rolph, Gregory Cooney

(2007), Vol. 56, pp. 2085-2092, Diabetes, C1-1

journal

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

Andrew Hoy, Clinton Bruce, Anna Cederberg, Nigel Turner, David James, Gregory Cooney, Edward Kraegen

(2007), Vol. 293, pp. E1358-E1364, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

Clinton Bruce, Camilla Brolin, Nigel Turner, Mark Cleasby, Feike van der Leij, Gregory Cooney, Edward Kraegen

(2007), Vol. 292, pp. E1231-E1237, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal
2006

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion

A Carey, E Petersen, C Bruce, R Southgate, H Pilegaard, John Hawley, B Pedersen, M Febbraio

(2006), Vol. 49, pp. 1000-1007, Diabetologia, C1-1

journal

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

Cheryl Collier, Clinton Bruce, Angela Smith, Gary Lopaschuk, David Dyck

(2006), Vol. 291, pp. E182-E189, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

Clinton Bruce, A Thrush, Valerie Mertz, Veronic Bezaire, Adrian Chabowski, George Heigenhauser, David Dyck

(2006), Vol. 291, pp. E99-E107, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal

Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation

Veronic Bezaire, Clinton Bruce, George Heigenhauser, Narendra Tandon, Jan Glatz, Joost Luiken, Arend Bonen, Lawrence Spriet

(2006), Vol. 290, pp. E509-E515, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal
2005

PGC-1? gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

Robert Southgate, Clinton Bruce, Andrew Carey, Gregory Steinberg, Ken Walder, Robert Monks, Matthew Watt, John Hawley, Morris Birnbaum, Mark Febbraio

(2005), Vol. 19, pp. 2072-2074, The FASEB journal, C1-1

journal

The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects

Clinton Bruce, Valerie Mertz, George Heigenhauser, David Dyck

(2005), Vol. 54, pp. 3154-3160, Diabetes, C1-1

journal

AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle

Angela Smith, Clinton Bruce, David Dyck

(2005), Vol. 565, pp. 537-546, The Journal of physiology, C1-1

journal

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle

Angela Smith, Clinton Bruce, David Dyck

(2005), Vol. 565, pp. 547-553, The Journal of physiology, C1-1

journal
2004

The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats

G Wadley, C Bruce, Nicky Konstantopoulos, S Macaulay, K Howlett, J Hawley, David Cameron-Smith

(2004), Vol. 47, pp. 412-419, Diabetologia, C1

journal

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

Melissa Arkinstall, Clinton Bruce, Sally Clark, Caroline Rickards, Louise Burke, John Hawley

(2004), Vol. 97, pp. 2275-2283, Journal of applied physiology, C1

journal

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

Todd Mitchell, Nigel Turner, A Hulbert, Paul Else, John Hawley, Jong Lee, Clinton Bruce, Stephen Blanksby

(2004), Vol. 97, pp. 1823-1829, Journal of Applied Physiology, C1-1

journal

Postexercise Muscle Triacylglycerol and Glycogen Metabolism in Obese Insulin-Resistant Zucker Rats

Clinton Bruce, Jong Lee, Bente Kiens, John Hawley

(2004), Vol. 12, pp. 1158-1165, Obesity research, C1-1

journal

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-?

Clinton Bruce, David Dyck

(2004), Vol. 287, pp. E616-E621, American Journal of Physiology-Endocrinology and Metabolism, C1-1

journal

Improvements in insulin resistance with aerobic exercise training: a lipocentric approach.

C Bruce, J Hawley

(2004), Vol. 36, pp. 1196-1201, Medicine and science in sports and exercise, C1-1

journal

Interleukin-6 and tumor necrosis factor-? are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness

A Carey, C Bruce, M Sacchetti, M Anderson, D Olsen, B Saltin, J Hawley, M Febbraio

(2004), Vol. 47, pp. 1029-1037, Diabetologia, C1-1

journal

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

Nigel Turner, Jong Lee, Clinton Bruce, Todd Mitchell, Paul Else, Alan Hulbert, John Hawley

(2004), Vol. 96, pp. 974-980, Journal of Applied Physiology, C1-1

journal

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

C Bruce, A Kriketos, G Cooney, J Hawley

(2004), Vol. 47, pp. 23-30, Diabetologia, C1-1

journal
2003

Dietary regulation of fat oxidative gene expression in different skeletal muscle fiber types

Andrew McAinch, Jong-Sam Lee, Clinton Bruce, Rebecca Tunstall, John Hawley, David Cameron-Smith

(2003), Vol. 11, pp. 1471-1479, Obesity research, C1

journal

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

Clinton Bruce, Mitchell Anderson, Andrew Carey, David Newman, Arend Bonen, Adamandia Kriketos, Gregory Cooney, John Hawley

(2003), Vol. 88, pp. 5444-5451, The Journal of Clinical Endocrinology & Metabolism, C1-1

journal

Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes Evidence That Insulin Resistance Is Associated With a Disturbed Antioxidant Defense Mechanism

Clinton Bruce, Andrew Carey, John Hawley, Mark Febbraio

(2003), Vol. 52, pp. 2338-2345, Diabetes, C1-1

journal
2002

Interaction of exercise and diet on GLUT-4 protein and gene expression in Type I and Type II rat skeletal muscle

J Lee, C Bruce, R Tunstall, David CAMERON-SMITH, H Hügel, J Hawley

(2002), Vol. 175, pp. 37-44, Acta physiologica scandinavica, C1

journal

Effect of different protocols of caffeine intake on metabolism and endurance performance

Gregory Cox, Ben Desbrow, Paul Montgomery, Megan Anderson, Clinton Bruce, Theodore Macrides, David Martin, Angela Moquin, Alan Roberts, John Hawley, others

(2002), Vol. 93, pp. 990-999, Journal of Applied Physiology, C1-1

journal

Effect Of Training On Activation Of Extracellular Signal-Regulated Kinase 1/2 And P38 Mitogen-Activated Protein Kinase Pathways In Rat Soleus Muscle

Jong Lee, Clinton Bruce, Brian Spurrell, John Hawley

(2002), Vol. 29, pp. 655-660, Clinical and experimental pharmacology and physiology, C1-1

journal
2001

Effect of carbohydrate ingestion on metabolism during running and cycling

Melissa Arkinstall, Clinton Bruce, Vasilis Nikolopoulos, Andrew Garnham, John Hawley

(2001), Vol. 91, pp. 2125-2134, Journal of applied physiology, C1

journal

Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats

Clinton Bruce, Jong Lee, John Hawley

(2001), Vol. 91, pp. 1512-1519, Journal of Applied Physiology, C1-1

journal

Interaction of diet and training on endurance performance in rats

Jong Lee, Clinton Bruce, Lawrence Spriet, John Hawley

(2001), Vol. 86, pp. 499-508, Experimental physiology, C1-1

journal
2000

Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion.

M Anderson, C Bruce, S Fraser, N Stepto, R Klein, W Hopkins, J Hawley

(2000), Vol. 10, pp. 464-475, International journal of sport nutrition and exercise metabolism, C1-1

journal

Enhancement of 2000-m rowing performance after caffeine ingestion

C Bruce, M Anderson, S Fraser, N Stepto, R Klein, W Hopkins, J Hawley

(2000), Vol. 32, pp. 1958-1963, Medicine and science in sports and exercise, Philadelphia, PA, C1-1

journal

Funded Projects at Deakin

Australian Competitive Grants

Activation of HSP72 in skeletal muscle as a therapeutic target for obesity

Prof Mark Febbraio, A/Prof Clinton Bruce, A/Prof Sean Mcgee, Prof Mark Hargreaves

NHMRC Project Grant

  • 2013: $20,000
  • 2012: $20,000

Sphingosine kinase: a target for obesity-induced insulin resistance

A/Prof Clinton Bruce, Dr Robert Lee-Young

NHMRC Project Grant

  • 2014: $251,815

Understanding the mechanisms of diet-induced defects in hepatic glucose metabolism.

A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2014: $60,000

Targeting hepatic energy expenditure to improve glycaemic control

Dr Greg Kowalski, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $30,000
  • 2014: $30,000

Does mitochondrial dysfunction impair muscle glucose metabolism?

A/Prof Clinton Bruce, Dr Greg Kowalski, Dr Gunveen Kaur

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $60,000

Liver-type pyruvate kinase: a novel anti-hyperglycemic target

Dr Greg Kowalski, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2016: $59,950

The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

A/Prof Sean Mcgee, A/Prof Clinton Bruce, Prof Forest White, Prof Ken Walder

NHMRC Project Grant

  • 2017: $169,227

Defining a novel pathway in the regulation of skeletal muscle mass

A/Prof Clinton Bruce

ARC Fellowships - Future Fellowships

  • 2017: $308,533

The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy

A/Prof Sean Mcgee, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2017: $59,962

Industry and Other Funding

Determination of 6,6-2H glucose enrichment in plasma

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2015: $1,920

Measurement of plasma free fatty acids

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2016: $2,200

Other Funding Sources

Determination of 6,6-2H glucose enrichment in plasma

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2017: $776
  • 2016: $1,520
  • 2015: $1,710

Determination of lipogenesis in liver cancer

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2016: $4,000

Supervisions

No completed student supervisions to report