Dr Clinton Bruce

STAFF PROFILE

Position

Senior Lecturer In Nutrition & Metabolism

Faculty

Faculty of Health

Department

School of Exercise & Nut. Sci.

Campus

Melbourne Burwood Campus

Qualifications

Doctor of Philosophy, Royal Melb Inst. of Technology, 2003

Contact

clinton.bruce@deakin.edu.au
+61 3 924 46684

Biography

Dr Bruce received his PhD from RMIT University in 2003 and completed postdoctoral appointments at the University of Guelph, Canada, the Garvan Institute of Medical Research and the Baker IDI Heart and Diabetes Institute. He established an independent laboratory in the Department of Physiology at Monash University in 2012 prior to taking up an academic appointment at Deakin University in 2014. 

Read more on Clinton's profile

Research interests

Dr Bruce’s research is focussed on understanding the regulation of glucose metabolism in skeletal muscle and liver in health and disease. He is particularly interested in identifying mechanisms underlying the development of glucose intolerance and insulin resistance.  He also has an interest in identifying the role of lipids in regulating skeletal muscle function. His research involves the use of stable isotope methodology and GC-MS based metabolomics to measure glucose and lipid fluxes, protein synthesis and mitochondrial biogenesis.

Affiliations

Member of the Australian Physiological Society (AuPS), the Australian Diabetes Society (ADS) and the Australian and New Zealand Metabolomics Network (ANZMN)

Units taught

Unit chair HSN751 Human Nutrition Research project Part B

Unit chair HSN703 Diet and Disease

Unit chair HSN753 Research Practice in Human Nutrition

Knowledge areas

Glucose metabolism, lipid metabolism, insulin resistance, type 2 diabetes, metabolomics, stable isotopes, muscle physiology

Expertise

Insulin resistance, glucose metabolism, hepatic glucose production, skeletal muscle physiology, lipid metabolism, tracers in metabolic research

Awards

2013-2014 Monash Researcher Accelerator Program
2013 Australian Diabetes Society annual meeting Pincus Taft Young Investigator awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).
2012 Australian Diabetes Society annual meeting best basic science poster awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).
2010-2013 NHMRC Career Development Award
2005-2009 NHMRC Peter Doherty Postdoctoral Fellowship
2000-2003 Australian Postgraduate Research Award

Projects

Mechanisms of glucose intolerance and insulin resistance.

The role of membrane lipids in regulating skeletal muscle physiology.

Publications

Filter by

2016

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

John M Wentworth, Gaetano Naselli, Katrina Ngui, Gordon K Smyth, Ruijie Liu, Paul E OBrien, Dr Clinton Bruce, Jacqui Weir, Michelle Cinel, A/Prof Peter Meikle, Leonard C. Harrison

(2016), Vol. 40, pp. 706-713, International journal of obesity, London, Eng., C1

journal

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

Graeme I Lancaster, Helene L Kammoun, Michael J Kraakman, Dr Greg Kowalski, Dr Clinton Bruce, Prof Mark Febbraio

(2016), Vol. 7, pp. 1-10, Nature communications, London, Eng., C1

journal
2015

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse.

Dr Greg Kowalski, David De Souza, Micah Burch, Mr Steven Hamley, Joachim Kloehn, Dr Ahrathy Selathurai, Dedreia L Tull, Prof Malcolm McConville, Dr Clinton Bruce

(2015), Vol. 462, pp. 27-32, Biochemical biophysical research communications, Amsterdam, The Netherlands, C1

journal

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

Michael J Kraakman, Helene L Kammoun, Tamara L Allen, Virginie Deswaerte, Darren C. Henstridge, Emma Estevez, Vance Matthews, Bronwyn A Neill, David White, Andrew J Murphy, Lone Peijs, Christine Yang, Steve Risis, Dr Clinton Bruce, Xiao-Jun Du, Alex Bobik, Dr Robert Lee-Young, Bronwyn A. Kingwell, Dr Wei Shi, Axel Kallies, Graeme I Lancaster, Stefan Rose-John, Prof Mark Febbraio

(2015), Vol. 21, pp. 403-416, Cell metabolism, Amsterdam, The Netherlands, C1-1

journal

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

Ruth C Meex, Andrew J Hoy, Rachael Mason, Miss Sheree Martin, A/Prof Sean Mcgee, Dr Clinton Bruce, Matthew J Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1

journal

In vivo cardiac glucose metabolism in the high-fat fed mouse: comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach

Dr Greg Kowalski, David De Souza, Steve Risis, Micah Burch, Mr Steven Hamley, Joachim Kloehn, Dr Ahrathy Selathurai, Dr Robert Lee-Young, Dedreia L Tull, Sean OCallaghan, Prof Malcolm McConville, Dr Clinton Bruce

(2015), Vol. 463, pp. 818-824, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

Mr Patricio Sepulveda, Dr Severine Lamon, Adam Hagg, Ms Rachel Thomson, Catherine E Winbanks, Hongwei Qian, Dr Clinton Bruce, Prof Aaron Russell, Dr Paul Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

journal

Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism

Ruth C Meex, Andrew J Hoy, Alexander J Morris, Russell D Brown, Jennifer Lo, Melissa Burke, Robert Goode, Bronwyn A. Kingwell, Michael J Kraakman, Prof Mark Febbraio, Jan Willem Greve, Sander Rensen, Mark Molloy, Graeme I Lancaster, Dr Clinton Bruce, Matthew J Watt

(2015), Vol. 22, pp. 1078-1089, Cell metabolism, St. Louis, M. O., C1-1

journal

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

Dr Ahrathy Selathurai, Dr Greg Kowalski, Micah Burch, Mr Patricio Sepulveda, Steve Risis, Dr Robert Lee-Young, Dr Severine Lamon, A/Prof Peter Meikle, Dr Amanda Genders, A/Prof Sean Mcgee, Matthew J Watt, Prof Aaron Russell, Matthew Frank, Suzanne Jackowski, Prof Mark Febbraio, Dr Clinton Bruce

(2015), Vol. 21, pp. 718-730, Cell metabolism, United States, C1

journal
2014

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

Nigel Turner, Gregory Cooney, Edward W Kraegen, Dr Clinton Bruce

(2014), Vol. 220, pp. T61-T79, Journal of endocrinology, Bristol, England, C1-1

journal

Growing healthy muscles to optimise metabolic health into adult life

Dr Stephanie Bayol, Dr Clinton Bruce, Dr Glenn Wadley

(2014), Vol. 5, pp. 420-434, Journal of developmental origins of health and disease, Cambridge, United Kingdom, C1

journal

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Rachael Mason, Ruzaidi Mokhtar, Maria Matzaris, Dr Ahrathy Selathurai, Dr Greg Kowalski, Nancy Mokbel, A/Prof Peter Meikle, Dr Clinton Bruce, Mr Matthew Watt

(2014), Vol. 3, pp. 652-663, Molecular metabolism, Amsterdam, Netherlands, C1-1

journal

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

Dr Greg Kowalski, Dr Clinton Bruce

(2014), Vol. 307, pp. E859-E871, American journal of physiology-endocrinology and metabolism, Bethesda, MD, C1

journal

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

Dr Clinton Bruce, Kalman Tory, Attila Kolonics, Mr Timothy Connor, Mr Matthew Watt, Kevin Carpenter, Prof Mark Hargreaves, A/Prof Sean Mcgee, Andrea L Hevener

(2014), pp. 1881-1894, Diabetes, Alexandria, Virginia, C1

journal
2013

Plasma sphingosine-1-phosphate is elevated in obesity

Dr Greg Kowalski, Andrew L. Carey, Dr Ahrathy Selathurai, Bronwyn A. Kingwell, Dr Clinton Bruce

(2013), Vol. 8, pp. 1-7, Plos one, San Francisco, California, C1-1

journal

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

Birgitte Lindegaard, Vance Matthews, Claus Brandt, Pernille Hojman, Tamara L Allen, Emma Estevez, Mr Matthew Watt, Dr Clinton Bruce, Ole H Mortensen, Susanne Syberg, Caroline Rudnicka, Julie Abildgaard, Henriette Pilegaard, Juan Hidalgo, Susanne Ditlevsen, Thomas J Alsted, Andreas N Madsen, Bente K Pedersen, Prof Mark Febbraio

(2013), Vol. 62, pp. 3064-3074, Diabetes, Alexandria, Virginia, C1-1

journal

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle : changes occurring in the diaphragm

Shinji Miura, Yuko Kai, Miki Tadaishi, Yuka Tokutake, Kimitoshi Sakamoto, Dr Clinton Bruce, Prof Mark Febbraio, Kiyoshi Kita, Shigeru Chohnan, Osamu Ezaki

(2013), Vol. 305, pp. E213-E229, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1

journal

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Nigel Turner, Dr Greg Kowalski, Simon J Leslie, Steve Risis, Christine Yang, Dr Robert Lee-Young, Joanne R Babb, A/Prof Peter Meikle, Graeme I Lancaster, Darren C. Henstridge, Phillip James White, Edward W Kraegen, Andre Marette, Gregory Cooney, Prof Mark Febbraio, Dr Clinton Bruce

(2013), Vol. 56, pp. 1638-1648, Diabetologia, Berlin, Germany, C1-1

journal

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

Dr Clinton Bruce, Steve Risis, Joanne R Babb, Christine Yang, Dr Robert Lee-Young, Darren C. Henstridge, Prof Mark Febbraio

(2013), Vol. 154, pp. 65-76, Endocrinology, Washington, DC, C1-1

journal

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

James Boon, Andrew J Hoy, Romana Stark, Russell D Brown, Ruth C Meex, Darren C. Henstridge, Simon Schenk, A/Prof Peter Meikle, Jeffrey F Horowitz, Bronwyn A. Kingwell, Dr Clinton Bruce, Mr Matthew Watt

(2013), Vol. 62, pp. 401-410, Diabetes, Alexandria, Virginia, C1-1

journal
2012

Regulation of plasma ceramide levels with fatty acid oversupply : evidence that the liver detects and secretes de novo synthesised ceramide

Mr Matthew Watt, A C Barnett, Dr Clinton Bruce, Simon Schenk, Jeffrey F Horowitz, Andrew J Hoy

(2012), Vol. 55, pp. 2741-2746, Diabetologia, Berlin, Germany, C1-1

journal

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

Dr Clinton Bruce, Steve Risis, Joanne R Babb, Christine Yang, Dr Greg Kowalski, Dr Ahrathy Selathurai, Dr Robert Lee-Young, Jacquelyn M Weir, Kazuaki Yoshioka, Yoh Takuwa, A/Prof Peter Meikle, Stuart M Pitson, Prof Mark Febbraio

(2012), Vol. 61, pp. 3148-3155, Diabetes, Alexandria, Virginia, C1-1

journal

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

Darren C. Henstridge, Dr Clinton Bruce, C P Pang, Graeme I Lancaster, Tamara L Allen, Emma Estevez, Timothy Gardner, Jacquelyn M Weir, A/Prof Peter Meikle, K SL Lam, A Xu, Nobuharu Fujii, Laurie J. Goodyear, Prof Mark Febbraio

(2012), Vol. 55, pp. 2769-2778, Diabetologia, Berlin, Germany, C1-1

journal

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

Graeme I Lancaster, Beata Skiba, Christine Yang, Hayley Nicholls, Katherine G Langley, M.H. Stanley Chan, Dr Clinton Bruce, Gordon W Rewcastle, Peter R Shepherd, Michael Karin, Prof Mark Febbraio

(2012), Vol. 442, pp. 723-732, Biochemical journal, London, England, C1-1

journal

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes

Melissa Barber, Steve Risis, Christine Yang, A/Prof Peter Meikle, Margaret Staples, Prof Mark Febbraio, Dr Clinton Bruce

(2012), Vol. 7, pp. 1-12, Plos one, San Francisco, California, C1-1

journal
2011

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury : a predominant role of anti-inflammation

Xiao-Ming Gao, Yang Liu, David White, Yidan Su, Brian Drew, Dr Clinton Bruce, Helen Kiriazis, Qi Xu, Nicole Jennings, Alex Bobik, Prof Mark Febbraio, Bronwyn A. Kingwell, Richard Bucala, Gunter Fingerle-Rowson, Anthony M Dart, Eric F Morand, Xiao-Jun Du

(2011), Vol. 50, pp. 991-999, Journal of molecular and cellular cardiology, Amsterdam, The Netherlands, C1-1

journal

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation

Andrew J Hoy, Dr Clinton Bruce, Sarah M Turpin, Alexander J Morris, Prof Mark Febbraio, Mr Matthew Watt

(2011), Vol. 152, pp. 48-58, Endocrinology, Washington, DC, C1-1

journal

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

Dr Greg Kowalski, Hayley Nicholls, Steve Risis, Nadine Watson, Peter Kanellakis, Dr Clinton Bruce, Alex Bobik, Graeme I Lancaster, Prof Mark Febbraio

(2011), Vol. 54, pp. 888-899, Diabetologia, Berlin, Germany, C1-1

journal
2010

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness (Molecular Endocrinology (2008) 22, (1200-1212) DOI: 10.1210/me.2007-0485) erratum

Mr Matthew Watt, Bryce J.W van Denderen, Laura A Castelli, Dr Clinton Bruce, Andrew J Hoy, Edward W Kraegen, Lance Macaulay, Bruce E. Kemp

(2010), Vol. 24, pp. 1308-1308, Molecular endocrinology, Washington, DC, C1-1

journal

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

Vance Matthews, Tamara L Allen, Steve Risis, M.H. Stanley Chan, Darren C. Henstridge, Nadine Watson, Lee A Zaffino, Joanne R Babb, James Boon, A/Prof Peter Meikle, Dr Jeremy Jowett, Mr Matthew Watt, John Olov Jansson, Dr Clinton Bruce, Prof Mark Febbraio

(2010), Vol. 53, pp. 2431-2441, Diabetologia, Berlin, Germany, C1-1

journal

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

Todd W Mitchell, Nigel Turner, Paul L Else, Anthony J Hulbert, John A. Hawley, Jong-Sam Lee, Dr Clinton Bruce, Stephen J Blanksby

(2010), Vol. 11, pp. 3954-3964, International journal of molecular sciences, Basel, Switzerland, C1-1

journal
2009

Reactive oxygen species enhance insulin sensitivity

Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Dr Clinton Bruce, Benjamin J Shields, Beata Skiba, Lisa A Ooms, Nigel K Stepto, Ben Wu, Prof Christina Mitchell, Nicholas K Tonks, Mr Matthew Watt, Prof Mark Febbraio, Peter J. Crack, Dr Sofianos Andrikopoulos, Tony Tiganis

(2009), Vol. 10, pp. 260-272, Cell metabolism, Cambridge, Mass., C1-1

journal

α2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise

Shinji Miura, Yuko Kai, Yasutomi Kamei, Dr Clinton Bruce, Naoto Kubota, Prof Mark Febbraio, Takashi Kadowaki, Osamu Ezaki

(2009), Vol. 296, pp. E47-E55, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1

journal

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

Dr Clinton Bruce, Andrew J Hoy, Nigel Turner, Mr Matthew Watt, Tamara L Allen, Kevin Carpenter, Gregory Cooney, Prof Mark Febbraio, Edward W Kraegen

(2009), Vol. 58, pp. 550-558, Diabetes, Alexandria, Virginia, C1-1

journal

AMP-activated protein kinase and muscle insulin resistance

Edward W Kraegen, Dr Clinton Bruce, Bronwyn D Hegarty, Ji-Ming Ye, Nigel Turner, Gregory Cooney

(2009), Vol. 14, pp. 4658-4672, Frontiers in bioscience, Irvine, California, C1-1

journal

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt or AS160 phosphorylation

Andrew J Hoy, Amanda E Brandon, Nigel Turner, Mr Matthew Watt, Dr Clinton Bruce, Gregory Cooney, Edward W Kraegen

(2009), Vol. 297, pp. E67-E75, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1

journal

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Vance Matthews, Maj Briit Astrom, M.H. Stanley Chan, Dr Clinton Bruce, Karen Suarez Krabbe, Oja Prelovsek, T Akerstrom, Christina Yfanti, Christa Broholm, Ole H Mortensen, Milena Penkowa, Pernille Hojman, Alaa Zankari, Mr Matthew Watt, Helle Bruunsgaard, Bente K Pedersen, Prof Mark Febbraio

(2009), Vol. 52, pp. 1409-1418, Diabetologia, Berlin, Germany, C1-1

journal
2008

HSP72 protects against obesity-induced insulin resistance

Jason Chung, Anh-Khoi Nguyen, Darren C. Henstridge, Anna G. Holmes, M.H. Stanley Chan, Jose L Mesa, Graeme I Lancaster, Robert J. Southgate, Dr Clinton Bruce, Stephen J. Duffy, Ibolya Horvath, Rubin Mestril, Mr Matthew Watt, Philip L Hooper, Bronwyn A. Kingwell, Laszlo Vigh, Andrea L Hevener, Prof Mark Febbraio

(2008), Vol. 105, pp. 1739-1744, Proceedings of the National Academy of Sciences of the United States of America, Washington, DC, C1-1

journal

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness

Mr Matthew Watt, Bryce J.W van Denderen, Laura A Castelli, Dr Clinton Bruce, Andrew J Hoy, Edward W Kraegen, Lance Macaulay, Bruce E. Kemp

(2008), Vol. 22, pp. 1200-1212, Molecular endocrinology, Washington, DC, C1-1

journal

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats

Anna G. Holmes, Jose L Mesa, Bronwyn A Neill, Jason Chung, Andrew L. Carey, Dr Gregory Steinberg, Bruce E. Kemp, Robert J. Southgate, Graeme I Lancaster, Dr Clinton Bruce, Mr Matthew Watt, Prof Mark Febbraio

(2008), Vol. 198, pp. 367-374, Journal of endocrinology, Bristol, England, C1-1

journal
2007

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

Dr Clinton Bruce, Camilla Brolin, Nigel Turner, Mark Cleasby, Feike van der Leij, Gregory Cooney, Edward W Kraegen

(2007), Vol. 292, pp. E1231-E1237, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

Andrew J Hoy, Dr Clinton Bruce, Anna Cederberg, Nigel Turner, Prof David E James, Gregory Cooney, Edward W Kraegen

(2007), Vol. 293, pp. E1358-E1364, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents

Nigel Turner, Dr Clinton Bruce, Susuan Beale, Kyle Hoehn, Trina So, Michael Rolph, Gregory Cooney

(2007), Vol. 56, pp. 2085-2092, Diabetes, Alexandria, Va, C1-1

journal
2006

Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation

Veronic Bezaire, Dr Clinton Bruce, George Heigenhauser, Narendra Tandon, Jan Glatz, Joost Luiken, Arend Bonen, Prof Lawrence Spriet

(2006), Vol. 290, pp. E509-E515, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

Dr Clinton Bruce, A Brianne Thrush, Valerie Mertz, Veronic Bezaire, Adrian Chabowski, George Heigenhauser, David Dyck

(2006), Vol. 291, pp. E99-E107, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

Cheryl Collier, Dr Clinton Bruce, Angela Smith, Gary Lopaschuk, David Dyck

(2006), Vol. 291, pp. E182-E189, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion

Andrew L. Carey, E Wolsk petersen, Dr Clinton Bruce, Robert J. Southgate, Henriette Pilegaard, John A. Hawley, Bente K Pedersen, Prof Mark Febbraio

(2006), Vol. 49, pp. 1000-1007, Diabetologia, Heidelberg, Germany, C1-1

journal
2005

PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

Robert J. Southgate, Dr Clinton Bruce, Andrew L. Carey, Dr Gregory Steinberg, Prof Ken Walder, Robert Monks, Mr Matthew Watt, John A. Hawley, Morris J. Birnbaum, Prof Mark Febbraio

(2005), Vol. 19, pp. 2072-2074, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle

Angela Smith, Dr Clinton Bruce, David Dyck

(2005), Vol. 565, pp. 547-553, Journal of physiology, West Sussex, England, C1-1

journal

AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle

Angela Smith, Dr Clinton Bruce, David Dyck

(2005), Vol. 565, pp. 537-546, Journal of physiology, West Sussex, England, C1-1

journal

The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects

Dr Clinton Bruce, Valerie Mertz, George Heigenhauser, David Dyck

(2005), Vol. 54, pp. 3154-3160, Diabetes, Alexandria, Va, C1-1

journal
2004

The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats.

Dr Glenn Wadley, Dr Clinton Bruce, Dr Nicky Konstantopoulos, J.S.L. Macauley, Dr Kirsten Howlett, John A. Hawley, A/Prof David Cameron-Smith

(2004), Vol. 47, pp. 412-419, Diabetologia, Berlin, Germany, C1

journal

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

Melissa Arkinstall, Dr Clinton Bruce, Ms Sally Clark, Caroline Rickards, Prof Louise Burke, John A. Hawley

(2004), Vol. 97, pp. 2275-2283, Journal of applied physiology, United States, C1

journal

Interleukin-6 and tumor necrosis factor-α are not increased in patients with type 2 diabetes: Evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness

Andrew L. Carey, Dr Clinton Bruce, M Sacchetti, Mitchell J Anderson, David B Olsen, Bengt Saltin, John A. Hawley, Prof Mark Febbraio

(2004), Vol. 47, pp. 1029-1037, Diabetologia, Heidelberg, Germany, C1-1

journal

Improvements in insulin resistance with exercise training: a lipocentric approach

Dr Clinton Bruce, John A. Hawley

(2004), Vol. 36, pp. 1196-1201, Medicine and science in sports and exercise, Philadelphia, PA, C1-1

journal

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-α

Dr Clinton Bruce, David Dyck

(2004), Vol. 287, pp. E616-E621, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats

Dr Clinton Bruce, Sam Lee Jong, Bente Kiens, John A. Hawley

(2004), Vol. 12, pp. 1158-1165, Obesity research, Hoboken, N.J., C1-1

journal

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

Todd W Mitchell, Nigel Turner, Anthony J Hulbert, Paul L Else, John A. Hawley, Sam Lee Jong, Dr Clinton Bruce, Stephen J Blanksby

(2004), Vol. 97, pp. 1823-1829, Journal of applied physiology, Bethesda, Md., C1-1

journal

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

Dr Clinton Bruce, Adamandia Kriketos, Gregory Cooney, John A. Hawley

(2004), Vol. 47, pp. 23-30, Diabetologia, Heidelberg, Germany, C1-1

journal

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

Nigel Turner, Sam Lee Jong, Dr Clinton Bruce, Todd W Mitchell, Paul L Else, Anthony J Hulbert, John A. Hawley

(2004), Vol. 96, pp. 974-980, Journal of applied physiology, Bethesda, Md., C1-1

journal
2003

Dietary regulation of fat oxidative gene expression in different skeletal musle fiber types

Andrew J. McAinch, Jong-Sam Lee, Dr Clinton Bruce, Rebecca J. Tunstall, John A. Hawley, A/Prof David Cameron-Smith

(2003), Vol. 11, pp. 1471-1479, Obesity research, Baton Rouge, La., C1

journal

Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism

Dr Clinton Bruce, Andrew L. Carey, John A. Hawley, Prof Mark Febbraio

(2003), Vol. 52, pp. 2338-2345, Diabetes, Alexandria, Va, C1-1

journal

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

Dr Clinton Bruce, Mitchell J Anderson, Andrew L. Carey, David Newman, Arend Bonen, Adamandia Kriketos, Gregory Cooney, John A. Hawley

(2003), Vol. 88, pp. 5444-5451, Journal of clinical endocrinology and metabolism, Washington, DC, C1-1

journal
2002

Interaction of exercise and diet on GLUT-4 protein and gene expression in type I and type II rat skeletal muscle

Jong-Sam Lee, Dr Clinton Bruce, Rebecca J. Tunstall, A/Prof David Cameron-Smith, H Hugel, John A. Hawley

(2002), Vol. 175, pp. 37-44, Acta physiologica Scandinavica, Oxford, England, C1

journal

Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle

Sam Lee Jong, Dr Clinton Bruce, Brian E Spurrell, John A. Hawley

(2002), Vol. 29, pp. 655-660, Clinical and experimental pharmacology and physiology, Richmond, VIC, C1-1

journal

Effect of different protocols of caffeine intake on metabolism and endurance performance

Mr Gregory Cox, Ben Desbrow, Paul G Montgomery, Megan E Anderson, Dr Clinton Bruce, Theodore A Macrides, David T. Martin, Angela Moquin, Alan Roberts, John A. Hawley, Prof Louise Burke

(2002), Vol. 93, pp. 990-999, Journal of applied physiology, Bethesda, Md., C1-1

journal
2001

Effect of carbohydrate ingestion on metabolism during running and cycling

Melissa Arkinstall, Dr Clinton Bruce, Vasilis Nikolopoulos, Dr Andrew Garnham, John A. Hawley

(2001), Vol. 91, pp. 2125-2134, Journal of applied physiology, Bethesada, Md., C1

journal

Interaction of diet and training on endurance performance in rats

Sam Lee Jong, Dr Clinton Bruce, Prof Lawrence Spriet, John A. Hawley

(2001), Vol. 86, pp. 499-508, Experimental physiology, West Sussex, England, C1-1

journal

Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats

Dr Clinton Bruce, Sam Lee Jong, John A. Hawley

(2001), Vol. 91, pp. 1512-1519, Journal of applied physiology, Bethesda, Md., C1-1

journal
2000

Enhancement of 2000-m rowing performance after caffeine ingestion

Dr Clinton Bruce, Megan E Anderson, Dr Steve Fraser, Nigel K Stepto, Rudi Klein, Will Hopkins, John A. Hawley

(2000), Vol. 32, pp. 1958-1963, Medicine and science in sports and exercise, Philadelphia, PA, C1-1

journal

Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion

Megan E Anderson, Dr Clinton Bruce, Dr Steve Fraser, Nigel K Stepto, Rudi Klein, Will Hopkins, John A. Hawley

(2000), Vol. 10, pp. 464-475, International journal of sport nutrition and exercise metabolism, Champaign, IL, C1-1

journal