Dr Delphine Denoyer



Research Fellow (Grade 2)


Faculty of Sci Eng & Built Env


School of Life & Env. Sciences


Off-Campus (Home)


+61 3 924 45432


Dr Delphine Denoyer is a research fellow in the Centre for Cellular and Molecular Biology at Deakin University. She obtained her PhD in Biomedical Engineering in France in 2004, where she investigated the mechanisms of uptake of new radiopharmaceuticals in cancer cells. After being awarded a prestigious fellowship from NHMRC/INSERM (Australia/France research cooperation program), she relocated to Australia in 2007 to pursue her interest in preclinical validation of radiopharmaceuticals for imaging and therapy of cancers at the Peter MacCallum Cancer Centre, Melbourne. In November 2013, she joined the Metals in Medicine Laboratory. Her research focus moved to the metallomics field where she uses her expertise in translational research to investigate the role of copper in the development and growth of prostate cancer.

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Knowledge areas

Translational Research

Cancer Biology (in particular melanoma, prostate and breast cancers)


Preclinical validation of new compounds for imaging and therapy of cancer

PET/SPECT imaging, autoradiography


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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

S Masaldan, S Clatworthy, C Gamell, P Meggyesy, A-T Rigopoulos, S Haupt, Y Haupt, D Denoyer, P Adlard, A Bush, M Cater

(2018), Vol. 14, pp. 100-115, Redox biology, Amsterdam, The Netherlands, C1


Sulfonation of tyrosine as a method to improve biodistribution of peptide-based radiotracers: novel (18)F-labeled cyclic RGD analogues

M Haskali, D Denoyer, W Noonan, C Culinane, C Rangger, N Pouliot, R Haubner, P Roselt, R Hicks, C Hutton

(2017), Vol. 14, pp. 1169-1180, Molecular pharmaceutics, Washington, D.C., C1-1


[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo

A Martin, A Fuzer, A Becceneri, J da Silva, R Tomasin, D Denoyer, S-H Kim, K McIntyre, H Pearson, B Yeo, A Nagpal, X Ling, H Selistre-de-Araujo, P Vieira, M Cominetti, N Pouliot

(2017), Vol. 8, pp. 72260-72271, Oncotarget, Albany, N.Y., C1


Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution

D Denoyer, H Pearson, S Clatworthy, Z Smith, P Francis, R Llanos, I Volitakis, W Phillips, P Meggyesy, S Masaldan, M Cater

(2016), Vol. 7, pp. 37064-37080, Oncotarget, Albany, N.Y., C1


Ceruloplasmin is regulated by copper and lactational hormones in PMC42-LA mammary epithelial cell culture models

D Freestone, D Denoyer, M Jakab, M Ackland, M Cater, A Michalczyk

(2016), Vol. 8, pp. 941-950, Metallomics, Cambridge, Eng., C1


Tumour but not stromal expression of ?3 integrin is essential, and is required early, for spontaneous dissemination of bone-metastatic breast cancer.

R Carter, K Micocci, A Natoli, R Redvers, S Paquet-Fifield, A Martin, D Denoyer, X Ling, S Kim, R Tomasin, H Selistre-de-Araújo, R Anderson, N Pouliot

(2015), Vol. 235, pp. 760-772, Journal of Pathology, England, C1-1


Analysis of 177Lu-DOTA-octreotate therapy-induced DNA damage in peripheral blood lymphocytes of patients with neuroendocrine tumors

D Denoyer, P Lobachevsky, P Jackson, M Thompson, O Martin, R Hicks

(2015), Vol. 56, pp. 505-511, Journal of Nuclear Medicine, New York, N.Y., C1


Heterogeneous copper concentrations in cancerous human prostate tissues

D Denoyer, S Clatworthy, S Masaldan, P Meggyesy, M Cater

(2015), Vol. 75, pp. 1510-1517, Prostate, London, Eng., C1


Synthesis and in vivo evaluation of [123I]melanin-targeted agents

M Roberts, V Nguyen, M Ashford, P Berghofer, N Wyatt, A Krause-Heuer, T Pham, S Taylor, L Hogan, C Jiang, B Fraser, N Lengkeek, L Matesic, M Gregoire, D Denoyer, R Hicks, A Katsifis, I Greguric

(2015), Vol. 58, pp. 6214-6224, Journal of medicinal chemistry, Washington, DC., C1-1


Targeting copper in cancer therapy: 'copper that cancer'

D Denoyer, S Masaldan, S La Fontaine, M Cater

(2015), Vol. 7, pp. 1459-1476, Metallomics, London, Eng., C1


Molecular imaging of metabolism in cancer metastasis

N Pouliot, D Denoyer

(2014), Vol. 38, pp. 124-128, Cancer forum, Kogarah, N.S.W., C1


Foxp3 expression in macrophages associated with RENCA tumors in mice

C Devaud, C Yong, L John, J Westwood, C Duong, C House, D Denoyer, J Li, P Darcy, M Kershaw

(2014), Vol. 9, pp. 1-8, PLoS One, San Francisco, Calif., C1-1


Postchemotherapy and tumor-selective targeting with the La-specific DAB4 monoclonal antibody relates to apoptotic cell clearance

F Al-Ejeh, A Staudacher, D Smyth, J Darby, D Denoyer, C Tsopelas, R Hicks, M Brown

(2014), Vol. 55, pp. 772-779, JNM : The journal of nuclear medicine, New York, N.Y., C1-1


Bone-derived soluble factors and laminin-511 cooperate to promote migration, invasion and survival of bone-metastatic breast tumor cells

D Denoyer, N Kusuma, A Burrows, X Ling, L Jupp, R Anderson, N Pouliot

(2014), Vol. 32, pp. 63-73, Growth factors, London, England, C1-1


PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate

B Paterson, P Roselt, D Denoyer, C Cullinane, D Binns, W Noonan, C Jeffery, R Price, J White, R Hicks, P Donnelly

(2014), Vol. 43, pp. 1386-1396, Dalton transactions, Cambridge, Eng., C1-1


Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation

J Malaterre, C McPherson, D Denoyer, E Lai, J Hagekyriakou, S Lightowler, K Shudo, M Ernst, D Ashley, J Short, G Wheeler, R Ramsay

(2012), Vol. 1, pp. 469-479, Stem cells translational medicine, Durham, N. C., C1-1


Tumour targeting of Auger emitters using DNA ligands conjugated to octreotate

P Lobachevsky, J Smith, D Denoyer, C Skene, J White, B Flynn, D Kerr, R Hicks, R Martin

(2012), Vol. 88, pp. 1009-1018, International journal of radiation biology, London, England, C1-1


Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer

D Denoyer, L Kirby, K Waldeck, P Roselt, O Neels, T Bourdier, R Shepherd, A Katsifis, R Hicks

(2012), Vol. 39, pp. 703-712, European journal of nuclear medicine and molecular imaging, Heidelberg, Germany, C1-1


Integrin-dependent response to laminin-511 regulates breast tumor cell invasion and metastasis

N Kusuma, D Denoyer, J Eble, R Redvers, B Parker, R Pelzer, R Anderson, N Pouliot

(2012), Vol. 130, pp. 555-566, International journal of cancer, Hoboken, N. J., C1-1


Gallium-68 complex of a macrobicyclic cage amine chelator tethered to two integrin-targeting peptides for diagnostic tumor imaging

M Ma, O Neels, D Denoyer, P Roselt, J Karas, D Scanlon, J White, R Hicks, P Donnelly

(2011), Vol. 22, pp. 2093-2103, Bioconjugate chemistry, Washington, D. C., C1-1


Radiosynthesis and biological evaluation of L- and D-S-(3-[ 18F]fluoropropyl)homocysteine for tumor imaging using positron emission tomography

T Bourdier, R Shepherd, P Berghofer, T Jackson, C Fookes, D Denoyer, D Dorow, I Greguric, M Gregoire, R Hicks, A Katsifis

(2011), Vol. 54, pp. 1860-1870, Journal of medicinal chemistry, Washington, D. C., C1-1


Improved detection of regional melanoma metastasis using 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide, a melanin-specific PET probe, by perilesional administration

D Denoyer, T Potdevin, P Roselt, O Neels, L Kirby, I Greguric, A Katsifis, D Dorow, R Hicks

(2011), Vol. 51, pp. 115-122, Journal of nuclear medicine, Reston, Virginia, C1-1


High-contrast PET of melanoma using 18F-MEL050, a selective probe for melanin with predominantly renal clearance

D Denoyer, I Greguric, P Roselt, O Neels, N Aide, S Taylor, A Katsifis, D Dorow, R Hicks

(2010), Vol. 51, pp. 441-447, Journal of nuclear medicine, Reston, Virginia, C1-1


Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

J Stagg, U Divisekera, N McLaughlin, J Sharkey, S Pommey, D Denoyer, K Dwyer, M Smyth

(2010), Vol. 107, pp. 1547-1552, Proceedings of the National Academy of Sciences of the United States of America, Washington, D. C., C1-1


Discovery of [18F]N-(2-(diethylamino)ethyl)-6- fluoronicotinamide : a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance

I Greguric, S Taylor, D Denoyer, P Ballantyne, P Berghofer, P Roselt, T Pham, F Mattner, T Bourdier, O Neels, D Dorow, C Loc'h, R Hicks, A Katsifis

(2009), Vol. 52, pp. 5299-5302, Journal of medicinal chemistry, Washington, D. C., C1-1


Promising pre-clinical validation of targeted radionuclide therapy using a [131I] labelled iodoquinoxaline derivative for an effective melanoma treatment

M Bonnet-Duquennoy, J Papon, F Mishellany, D Denoyer, P Labarre, J Guerquin-Kern, F Penault-llorca, J Madelmont, E Miot-Noirault, A Cayre, J Chezal, N Moins

(2009), Vol. 1, pp. 1-7, Journal of cancer science & therapy, Los Angeles, California, C1-1


Development of a high-performance liquid chromatographic method for the determination of a new potent radioiodinated melanoma imaging and therapeutic agent

D Denoyer, P Labarre, J Papon, E Miot-Noirault, M Galmier, J Madelmont, J Chezal, N Moins

(2008), Vol. 875, pp. 411-418, Journal of chromatography B: analytical technologies in the biomedical and life sciences, Amsterdam, The Netherlands, C1-1


Study of monoglutathionyl conjugates TC-99M-sestamibi and TC-99M-tetrofosmin transport mediated by the multidrug resistance-associated protein isoform 1 in glioma cells

N Le Jeune, N Perek, D Denoyer, F Dubois

(2005), Vol. 20, pp. 249-259, Cancer biotherapy & radiopharmaceuticals, New Rochelle, N.Y., C1-1


Correlation between 99mTc-(V)-DMSA uptake and constitutive level of phosphorylated focal adhesion kinase in an in vitro model of cancer cell lines

D Denoyer, N Perek, N Le Jeune, J Cornillon, F Dubois

(2005), Vol. 32, pp. 820-827, European journal of nuclear medicine and molecular imaging, Heidelberg, Germany, C1-1


Influence of glutathione depletion on plasma membrane cholesterol esterification and on Tc-99m-sestamibi and Tc-99m-tetrofosmin uptakes: a comparative study in sensitive U-87-MG and multidrug-resistant MRP1 human glioma cells

N Le Jeune, N Perek, D Denoyer, F Dubois

(2004), Vol. 19, pp. 411-421, Cancer biotherapy & radiopharmaceuticals, New Rochelle, N.Y., C1-1


Evidence that 99mTc-(V)-DMSA uptake is mediated by NaPi cotransporter type III in tumour cell lines

D Denoyer, N Perek, N Le Jeune, D Frere, F Dubois

(2004), Vol. 31, pp. 77-84, European journal of nuclear medicine and molecular imaging, Berlin, Germany, C1-1


The multidrug resistance of in vitro tumor cell lines derived from human breast carcinoma MCF-7 does not influence pentavalent technetium-99m-dimercaptosuccinic Acid uptake

D Denoyer, N Perek, N Le Jeune, D Frère, F Dubois

(2003), Vol. 18, pp. 791-801, Cancer biotherapy & radiopharmaceuticals, New Rochelle, N.Y., C1-1


Modulation of the multidrug resistance of glioma by glutathione levels depletion--interaction with TC-99M-sestamibi and TC-99M-tetrofosmin

N Perek, F Koumanov, D Denoyer, D Boudard, F Dubois

(2002), Vol. 17, pp. 291-302, Cancer biotherapy & radiopharmaceuticals, New Rochelle, N.Y., C1-1


The multidrug resistance mechanisms and their interactions with the radiopharmaceutical probes used for an In Vivo detection

N Perek, D Denoyer

(2002), Vol. 3, pp. 97-113, Current drug metabolism, Beijing, China, C1-1


Funded Projects at Deakin

Industry and Other Funding

Can targeting lipid metabolism inhibit prostate cancer progression?

Dr Delphine Denoyer

  • 2017: $29,000
  • 2016: $29,000


No completed student supervisions to report