EmPr Julian Mercer

STAFF PROFILE

Position

Emeritus Professor

Faculty

Faculty of Sci Eng & Built Env

Department

Office of the Exec Dean SEBE

Campus

Melbourne Burwood Campus

Contact

julian.mercer@deakin.edu.au
+61 3 925 17329

Publications

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2017

A 37-year-old Menkes disease patient-Residual ATP7A activity and early copper administration as key factors in beneficial treatment

Z Tümer, M Petris, S Zhu, J Mercer, J Bukrinski, S Bilz, K Baerlocher, N Horn, L Møller

(2017), Vol. 92, pp. 548-553, Clinical Genetics, London, Eng., C1

journal article
2016

Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics

K Davies, J Mercer, N Chen, K Double

(2016), Vol. 130, pp. 565-574, Clinical science, London, Eng., C1

journal article

Characterizing the molecular phenotype of an: Atp7a T985I conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX)

G Perez-Siles, A Grant, M Ellis, C Ly, A Kidambi, M Khalil, R Llanos, S Fontaine, A Strickland, S Züchner, S Bermeo, E Neist, T Brennan-Speranza, R Takata, C Speck-Martins, J Mercer, G Nicholson, M Kennerson

(2016), Vol. 8, pp. 981-992, Metallomics, England, C1

journal article
2014

Copper pathology in vulnerable brain regions in Parkinson's disease

K Davies, S Bohic, A Carmona, R Ortega, V Cottam, D Hare, J Finberg, S Reyes, G Halliday, J Mercer, K Double

(2014), Vol. 36, pp. 858-866, Neurobiology of aging, Amsterdam, The Netherlands, C1

journal article

Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation

J Wadwa, Y Chu, N Nguyen, T Henson, A Figueroa, R Llanos, M Ackland, A Michalczyk, H Fullriede, G Brennan, J Mercer, M Linder

(2014), Vol. 2, pp. 1-11, Physiological Reports, Oxford, United Kingdom, C1

journal article

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

B Roberts, N Lim, E McAllum, P Donnelly, D Hare, P Doble, B Turner, K Price, S Lim, B Paterson, J Hickey, T Rhoads, J Williams, K Kanninen, L Hung, J Liddell, A Grubman, J Monty, R Llanos, D Kramer, J Mercer, A Bush, C Masters, J Duce, Q Li, J Beckman, K Barnham, A White, P Crouch

(2014), Vol. 34, pp. 8021-8031, Journal of neuroscience, Washington, D.C., C1

journal article

Metabolism and functions of copper in brain

I Scheiber, J Mercer, R Dringen

(2014), Vol. 116, pp. 33-57, Progress in neurobiology, London, Eng., C1

journal article
2013

Copper transporting P-Type ATPases in the brain

S La Fontaine, J Camakaris, J Mercer

(2013), pp. 137-168, Brain diseases and metalloproteins, Boca Raton, Fla., B1-1

book chapter

Copper : effects of deficiency and overload

I Scheiber, R Dringen, J Mercer

(2013), pp. 359-387, Interrelations between essential metal ions and human diseases, Berlin, Germany, B1-1

book chapter

Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons

J Liu, Y Kim, F Yan, Q Ding, V Ip, N Jong, J Mercer, M McKeage

(2013), Vol. 85, pp. 207-215, Biochemical pharmacology, Amsterdam, The Netherlands, C1

journal article

Localization of copper and copper transporters in the human brain

K Davies, D Hare, V Cottam, N Chen, L Hilgers, G Halliday, J Mercer, K Double

(2013), Vol. 5, pp. 43-51, Metallomics, Cambridge, England, C1

journal article

Nonsense-mediated mRNA decay of collagen -emerging complexity in RNA surveillance mechanisms

Y Fang, J Bateman, J Mercer, S Lamande

(2013), Vol. 126, pp. 2551-2560, Journal of cell science, Cambridge, England, C1

journal article

Copper metabolism of astrocytes

R Dringen, I Scheiber, J Mercer

(2013), Vol. 5, pp. 1-4, Frontiers in aging neuroscience, Lausanne, Switzerland, C1

journal article

Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase

V Sudhahar, N Urao, J Oshikawa, R McKinney, R Llanos, J Mercer, M Ushio-Fukai, T Fukai

(2013), Vol. 62, pp. 3839-3850, Diabetes, Alexandria, Va., C1-1

journal article
2012

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B

S Materia, M Cater, L Klomp, J Mercer, S La Fontaine

(2012), Vol. 287, pp. 2485-2499, Journal of biological chemistry, Bethesda, Md., C1

journal article

Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy

L Yi, A Donsante, M Kennerson, J Mercer, J Garbern, S Kaler

(2012), Vol. 21, pp. 1794-1807, Human molecular genetics, Oxford, England, C1

journal article

Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice

Y Chu, E Sauble, A Cabrera, A Roth, M Ackland, J Mercer, M Linder

(2012), Vol. 25, pp. 373-382, BioMetals, Dordrecht, The Netherlands, C1

journal article
2011

Clusterin (APOJ) : a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B

S Materia, M Cater, L Klomp, J Mercer, S La Fontaine

(2011), Vol. 286, pp. 10073-10083, Journal of biological chemistry, Bethesda, Md., C1

journal article
2010

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B : emerging roles

S La Fontaine, M Ackland, J Mercer

(2010), Vol. 42, pp. 206-209, International journal of biochemistry & cell biology, Oxford, England, C1

journal article

Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B

W Singleton, K McInnes, M Cater, W Winnall, R McKirdy, Y Yu, P Taylor, B Ke, D Richardson, J Mercer, S La Fontaine

(2010), Vol. 285, pp. 27111-27121, Journal of biological chemistry, Bethesda, Md., C1

journal article

Copper accumulation by cultured astrocytes

I Scheiber, J Mercer, R Dringen

(2010), Vol. 56, pp. 451-460, Neurochemistry International, Oxford, England, C1

journal article

Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue

V Ip, J Liu, J Mercer, M McKeage

(2010), Vol. 6, pp. 1-10, Molecular pain, London, England, C1

journal article

Missense mutations in the copper transporter gene ATP7A cause X-Linked distal hereditary motor neuropathy

M Kennerson, G Nicholson, S Kaler, B Kowalski, J Mercer, J Tang, R Llanos, S Chu, R Takata, C Speck-Martins, J Baets, L Almeida-Souza, D Fischer, V Timmerman, P Taylor, S Scherer, T Ferguson, T Bird, P De Jonghe, S Feely, M Shy, J Garbern

(2010), Vol. 86, pp. 342-352, American journal of human genetics, Cambridge, Mass., C1-1

journal article
2009

Neuronal expression of copper transporter 1 in rat dorsal root ganglia : association with platinum neurotoxicity

J Liu, S Jamieson, J Subramaniam, V Ip, N Jong, J Mercer, M McKeage

(2009), Vol. 64, pp. 847-856, Cancer chemotherapy and pharmacology, Berlin, Germany, C1-1

journal article

Leptin: Back and Forward

Julian Mercer

(2009), Vol. 21, pp. 1063-1064, JOURNAL OF NEUROENDOCRINOLOGY, United States, C1-1

journal article
2008

ATP7B expression in human breast epithelial cells is mediated by lactational hormones

A Michalczyk, E Bastow, M Greenough, J Camakaris, D Freestone, P Taylor, M Linder, J Mercer, M Ackland

(2008), Vol. 56, pp. 389-399, Journal of histochemistry and cytochemistry, Seattle, Wash., C1

journal article

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

R Llanos, A Michalczyk, D Freestone, S Currie, M Linder, M Ackland, J Mercer

(2008), Vol. 372, pp. 613-617, Biochemical and biophysical research communications, San Diego, Calif., C1

journal article

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

M Cater, K McInnes, Q Li, I Volitalis, S La Fontaine, J Mercer, A Bush

(2008), Vol. 412, pp. 141-152, Biochemical journal, London, England, C1-1

journal article

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

T Du, S La Fontaine, M Abdo, S Bellingham, M Greenough, I Volitakis, R Cherny, A Bush, P Hudson, J Camakaris, J Mercer, P Crouch, C Masters, V Perreau, A White

(2008), Vol. 8, pp. 1819-1831, Proteomics, Weinheim, Germany, C1-1

journal article

ATP7A transgenic and nontransgenic mice are resistant to high copper exposure

B Ke, R Llanos, J Mercer

(2008), Vol. 138, pp. 693-697, Journal of nutrition, Bethesda, Md., C1-1

journal article
2007

Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson Protein (ATP7B)

M Cater, S La Fontaine, J Mercer

(2007), Vol. 401, pp. 143-153, Biochemical journal, London, England, C1

journal article

Copper-transporting P-Type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer

S Owatari, S Akune, M Komatsu, R Ikeda, S Firth, X Che, M Yamamoto, K Tsujikawa, M Kitazono, T Ishizawa, T Takeuchi, T Aikou, J Mercer, S Akiyama, T Furukawa

(2007), Vol. 67, pp. 4860-4868, Cancer research, Philadelphia, Pa., C1

journal article

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells

B Hardman, A Michalczyk, M Greenough, J Camakaris, J Mercer, L Ackland

(2007), Vol. 402, pp. 241-250, Biochemical journal, London, England, C1

journal article

Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A)

Y Hung, M Layton, I Voskoboinik, J Mercer, J Camakaris

(2007), Vol. 401, pp. 569-579, Biochemical journal, London, England, C1

journal article

Trafficking of the copper-ATPases, ATP7A and ATP7B: Role in copper homeostasis

S La Fontaine, J Mercer

(2007), Vol. 463, pp. 149-167, Archives of biochemistry and biophysics, Amsterdam, The Netherlands, C1

journal article

Heterozygous tx mice have an increased sensitivity to copper loading: implications for Wilson's Disease carriers

D Cheah, Y Deal, P Wright, N Buck, C Chow, J Mercer, K Allen

(2007), Vol. 20, pp. 751-757, BioMetals, Amsterdam, The Netherlands, C1

journal article

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental Cells

B Hardman, A Michalczyk, M Greenough, J Camakaris, J Mercer, L Ackland

(2007), Vol. 20, pp. 1073-1084, Cellular physiology and biochemistry, Basel, Switzerland, C1

journal article
2006

Copper in mammals: mechanisms of homeostasis and pathophysiology

M Cater, J Mercer

(2006), pp. 101-120, Molecular biology of metal homeostasis and detoxification : from microbes to man, Berlin, Germany, B1

book chapter

Correction of a mouse model of Menkes disease by the human Menkes gene

R Llanos, B Ke, M Wright, Y Deal, F Monty, D Kramer, J Mercer

(2006), Vol. 1762, pp. 485-493, Biochimica et biophysica acta (BBA) - molecular basis of disease, Amsterdam, The Netherlands, C1

journal article

Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells

B Hardman, U Manuelpillai, E Wallace, J Monty, D Kramer, Y Kuo, J Mercer, L Ackland

(2006), Vol. 27, pp. 968-977, Placenta, London, England, C1

journal article

Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A

C Lim, M Cater, J Mercer, S La Fontaine

(2006), Vol. 281, pp. 14006-14014, Journal of biological chemistry, Bethesda, Md, C1

journal article

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

C Lim, M Cater, J Mercer, S La Fontaine

(2006), Vol. 348, pp. 428-436, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal article

Alteration of copper physiology in mice overexpressing the human menkes protein ATP7A

B Ke, R Llanos, M Wright, Y Deal, J Mercer

(2006), Vol. 290, pp. 1460-1467, American journal of physiology : regulatory, interative comparative physiology, Bethesda, Md., C1

journal article

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

M Cater, S La Fontaine, K Shield, Y Deal, J Mercer

(2006), Vol. 130, pp. 493-506, Gastroenterology, Amsterdam, Nertherlands, C1

journal article

Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading

K Allen, N Buck, D Cheah, S Gazeas, P Bhathal, J Mercer

(2006), Vol. 19, pp. 555-564, BioMetals, Amsterdam, The Netherlands, C1

journal article
2005

Copper exposure induces trafficking of the Menkes protein in intestinal epithelium of ATP7A transgenic mice

J Monty, R Llanos, J Mercer, D Kramer

(2005), Vol. 135, pp. 2762-2766, Journal of nutrition, Bethesda, Md., C1

journal article

A single PDZ domain protein interacts with the menkes copper ATPase, ATP7A : a new protein implicated in copper homeostasis

S Stephenson, D Dubach, C Lim, J Mercer, S La Fontaine

(2005), Vol. 280, pp. 33270-33279, Journal of biological chemistry, Baltimore, Md, C1-1

journal article
2004

Expression and localization of Menkes and Wilson copper transporting ATPases in human placenta

B Hardman, U Manuelpillai, E Wallace, S van de Waasenburg, M Cater, J Mercer, L Ackland

(2004), Vol. 25, pp. 512-517, Placenta, Amsterdam, Netherlands, C1

journal article

Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites

M Cater, J Forbes, S La Fontaine, D Cox, J Mercer

(2004), Vol. 380, pp. 805-813, Biochemical journal, London, England, C1

journal article

Liver cell transplantation leads to repopulation and functional correction in a mouse model of Wilson's disease

K Allen, D Cheah, P Wright, S Gazeas, N Pettigrew-Buck, Y Deal, J Mercer, R Williamson

(2004), Vol. 19, pp. 1283-1290, Journal of gastroenterology and hepatology, New York, NY., C1

journal article

The potential of bone marrow stem cells to correct liver dysfunction in a mouse model of Wilson's disease

K Allen, D Cheah, L Xiao, N Pettigrew-Buck, J Vadolas, J Mercer, P Ioannou, R Williamson

(2004), Vol. 13, pp. 765-773, Cell Transplantation, United States, C1-1

journal article
2003

Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

D Kramer, R Llanos, J Mercer

(2003), pp. 207-244, Metal ions and neurodegenerative disorders, Singapore, B1

book chapter

Molecular and cellular aspects of copper transport in developing mammals

J Mercer, R Llanos

(2003), Vol. 133, Journal of nutrition, Bethesda, Md., C1

journal article

Copper-induced trafficking of the Cu-ATPase: a key mechanism for copper homeostasis

J Mercer, N Barnes, J Stevenson, D Strausak, R Llanos

(2003), Vol. 16, pp. 175-184, BioMetals, Amsterdam, The Netherlands, C1

journal article

Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein

D Strausak, M Howie, S Firth, A Schlicksupp, R Pipkorn, G Multhaup, J Mercer

(2003), Vol. 278, pp. 20821-20827, Journal of biological chemistry, Baltimore, Md., C1

journal article

Endosomal trafficking of the Menkes copper ATPase ATP7A is mediated by vesicles containing the Rab7 and Rab5 GTPase proteins

M Pascale, S Franceschelli, O Moltedo, F Belleudi, M Torrisi, C Bucci, S La Fontaine, J Mercer, A Leone

(2003), Vol. 291, pp. 377-385, Experimental cell research, San Diego, Calif, C1

journal article
2002

Molecular basis of diseases of copper homeostasis

J Mercer, D Kramer, J Camakaris

(2002), pp. 249-276, Handbook of copper pharmacology and toxicology, Totowa, N.J., B1

book chapter

Understanding the mechanism and function of copper P-type ATPases

I Voskoboinik, J Camakaris, J Mercer

(2002), pp. 123-150, Copper-containing proteins, San Diego, Calif., B1

book chapter

Correction of the copper transport defect of Menkes patient fibroblasts by expression of two forms of the sheep Wilson ATPase

P Lockhart, S La Fontaine, S Firth, M Greenough, J Camakaris, J Mercer

(2002), Vol. 1588, pp. 189-194, Biochimica et biophysica acta (BBA) - molecular basis of disease, Netherlands, C1

journal article

The molecular basis of copper homeostasis and copper-related disorders

R Llanos, J Mercer

(2002), Vol. 21, pp. 259-270, DNA and cell biology, New York, N.Y., C1

journal article

Copper-regulated trafficking of the Menkes disease copper ATPase associated with formation of a phosphorylated catalytic intermediate

M Petris, I Voskoboinik, M Cater, K Smith, B Kim, R Llanos, D Strausak, J Camakaris, J Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Baltimore, Md., C1

journal article
2001

The molecular basis of copper-transport diseases

J Mercer

(2001), Vol. 7, pp. 64-69, Trends in molecular medicine, New York, N.Y., C1

journal article

Functional analysis of the sheep Wilson disease protein (sATP7B) in CHO cells

P Lockhart, J Mercer

(2001), Vol. 80, pp. 349-357, European journal of cell biology, Amsterdam, The Netherlands, C1

journal article

Copper in disorders with neurological symptoms: Alzheimer`s, Menkes, and Wilson Diseases

D Strausak, J Mercer, H Dieter, W Stremmel, G Multhaup

(2001), Vol. 55, pp. 175-185, Brain research bulletin, New York, NY, C1

journal article

Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copperATPase

S La Fontaine, M Theophilos, S Firth, R Gould, R Parton, J Mercer

(2001), Vol. 10, pp. 361-370, Human molecular genetics, Oxford, England, C1

journal article

Functional studies on the Wilson copper P-Type ATPase and toxic milk mouse mutant

I Voskoboinik, M Greenough, S La Fontaine, J Mercer, J Camakaris

(2001), Vol. 281, pp. 966-970, Biochemical and biophysical research communications, San Diego, Calif, C1

journal article

Expression of the human Menkes ATPase in Xenopus laevis oocytes

K Bissig, S La Fontaine, J Mercer, M Solioz

(2001), Vol. 382, pp. 711-714, Biological chemistry, Berlin, Germany, C1-1

journal article
2000

Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation

A Michalczyk, J Rieger, K Allen, J Mercer, M Ackland

(2000), Vol. 352, pp. 565-571, Biochemical journal, London, Eng., C1-1

journal article

Identification of the copper chaperone SAH in Ovis aries: Expression analysis and in vitro interaction of SAH with ATP7B

P Lockhart, J Mercer

(2000), Vol. 1490, pp. 11-20, Biochimica et Biophysica Acta - Gene Structure and Expression, Netherlands, C1-1

journal article

Cloning, mapping and expression analysis of the sheep Wilson disease gene homologue

P Lockhart, S Wilcox, H Dahl, J Mercer

(2000), Vol. 1491, pp. 229-239, Biochimica et Biophysica Acta - Gene Structure and Expression, Netherlands, C1-1

journal article

The Menkes copper transporter is required for the activation of tyrosinase

M Petris, D Strausak, J Mercer

(2000), Vol. 9, pp. 2845-2851, Human Molecular Genetics, England, C1-1

journal article

Conditionally immortalized mouse hepatocytes use in liver gene therapy

K Allen, R Reyes, K Demmler, J Mercer, R Williamson, R Whitehead

(2000), Vol. 15, pp. 1325-1332, Journal of Gastroenterology and Hepatology (Australia), Australia, C1-1

journal article
1999

Functional analysis of the Menkes protein (MNK) expressed from a cDNA construct

S La Fontaine, S Firth, P Lockhart, H Brooks, J Camakaris, J Mercer

(1999), Vol. 448, pp. 67-82, Copper transport and its disorders: Molecular and cellular aspects, Berline, Germany, B1-1

book chapter

Expression of Menkes copper-transporting ATPase, MNK, in the lactating human breast: possible role in copper transport into milk

M Ackland, P Anikijenko, A Michalczyk, J Mercer

(1999), Vol. 47, pp. 1553-1562, Journal of Histochemistry and Cytochemistry, Thousand Oaks, Calif., C1-1

journal article

The role of GMXCXXC metal binding sites in the copper-induced redistribution of the Menkes protein

D Strausak, S La Fontaine, J Hill, S Firth, P Lockhart, J Mercer

(1999), Vol. 274, pp. 11170-11177, Journal of Biological Chemistry, Bethesda, Md., C1-1

journal article

Intracellular localization and loss of copper responsiveness of Mnk, the murine homologue of the Menkes protein, in cells from blotchy (Mo blo) and brindled (Mo br) mouse mutants

S La Fontaine, S Firth, P Lockhart, H Brooks, J Camakaris, J Mercer

(1999), Vol. 8, pp. 1069-1075, Human Molecular Genetics, Oxford, Eng., C1-1

journal article

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

A White, R Reyes, J Mercer, J Camakaris, H Zheng, A Bush, G Multhaup, K Beyreuther, C Masters, R Cappai

(1999), Vol. 842, pp. 439-444, Brain Research, Netherlands, C1-1

journal article

The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal

M Petris, J Mercer

(1999), Vol. 8, pp. 2107-2115, Human Molecular Genetics, England, C1-1

journal article

Molecular mechanisms of copper homeostasis

J Camakaris, I Voskoboinik, J Mercer

(1999), Vol. 261, pp. 225-232, Biochemical and Biophysical Research Communications, United States, C1-1

journal article

Cloning and expression analysis of the sheep ceruloplasmin cDNA

P Lockhart, J Mercer

(1999), Vol. 236, pp. 251-257, Gene, Netherlands, C1-1

journal article

Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease

L Ambrosini, J Mercer

(1999), Vol. 8, pp. 1547-1555, Human Molecular Genetics, England, C1-1

journal article

Functional analysis of the N-terminal CXXC metal-binding motifs in the human Menkes copper-transporting P-type ATPase expressed in cultured mammalian cells

I Voskoboinik, D Strausak, M Greenough, H Brooks, M Petris, S Smith, J Mercer, J Camakaris

(1999), Vol. 274, pp. 22008-22012, Journal of Biological Chemistry, United States, C1-1

journal article

Animal models of menkes disease

J Mercer, L Ambrosini, S Horton, S Gazeas, A Grimes

(1999), Vol. 448, pp. 97-108, Advances in Experimental Medicine and Biology, ITALY, SESTRI LEVANTE, E1-1

conference

The cell biology of the menkes disease protein

M Petris, J Mercer, J Camakaris

(1999), Vol. 448, pp. 53-66, Advances in Experimental Medicine and Biology, ITALY, SESTRI LEVANTE, E1-1

conference

Mutational analysis of the copper ATPase affected in Menkes disease

D Strausak, L Ambrosini, J Mercer

(1999), pp. 291-300, METALS AND GENETICS, CANADA, TORONTO, E1-1

conference
1998

Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases

S La Fontaine, S Firth, J Camakaris, A Englezou, M Theophilos, M Petris, M Howie, P Lockhart, M Greenough, H Brooks, R Reddel, J Mercer

(1998), Vol. 273, pp. 31375-31380, Journal of biological chemistry, Rockville, Md., C1-1

journal article

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network

M Petris, J Camakaris, M Greenough, S LaFontaine, J Mercer

(1998), Vol. 7, pp. 2063-2071, Human molecular genetics, Oxford, Eng., C1-1

journal article

Analysis of the distribution of Cu, Fe and Zn and other elements in brindled mouse kidney using a scanning proton microprobe

B Kirby, D Danks, G Legge, J Mercer

(1998), Vol. 71, pp. 189-197, Journal of Inorganic Biochemistry, United States, C1-1

journal article

Menkes syndrome and animal models

J Mercer

(1998), Vol. 67, pp. 1022S-1028S, American Journal of Clinical Nutrition, MARYLAND, NIH, BETHESDA, E1-1

conference
1997

Expression of Menkes disease gene in mammary carcinoma cells

M Ackland, E Cornish, A Paynter, A Grimes, A Michalczyk, F Mercer

(1997), Vol. 328, pp. 237-243, Biochemical journal, London, Eng., C1-1

journal article

A phosphoglycerate mutase brain isoform (PGAM 1) pseudogene is localized within the human Menkes disease gene (ATP7 A)

H Dierick, J Mercer, T Glover

(1997), Vol. 198, pp. 37-41, Gene, Netherlands, C1-1

journal article

Decreased carbonic anhydrase III levels in the liver of the mouse mutant 'toxic milk' (tx) due to copper accumulation

A Grimes, J Paynter, I Walker, M Bhave, J Mercer

(1997), Vol. 321, pp. 341-345, Biochemical Journal, England, C1-1

journal article

Molecular basis of the brindled mouse mutant (Mo(br)): A murine model of Menkes disease

A Grimes, C Hearn, P Lockhart, D Newgreen, J Mercer

(1997), Vol. 6, pp. 1037-1042, Human Molecular Genetics, England, C1-1

journal article
1996

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking

M Petris, J Mercer, J Culvenor, P Lockhart, P Gleeson, J Camakaris

(1996), Vol. 15, pp. 6084-6095, EMBO Journal, England, C1-1

journal article

The toxic milk mouse is a murine model of Wilson disease

M Theophilos, D Cox, J Mercer

(1996), Vol. 5, pp. 1619-1624, Human Molecular Genetics, England, C1-1

journal article
1995

Molecular structure of the menkes disease gene (ATP7A)

H Dierick, L Ambrosini, J Spencer, T Glover, J Mercer

(1995), Vol. 28, pp. 462-469, Genomics, United States, C1-1

journal article

Gene amplification of the menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

J Camakaris, M Petris, L Bailey, P Shen, P Lockhart, T Glover, C Barcroft, J Patton, J Mercer

(1995), Vol. 4, pp. 2117-2123, Human Molecular Genetics, England, C1-1

journal article
1994

Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice

J Mercer, A Grimes, L Ambrosini, P Lockhart, J Paynter, H Dierick, T Glover

(1994), Vol. 6, pp. 374-378, Nature Genetics, United States, C1-1

journal article

The pathology and trace element status of the toxic milk mutant mouse

J Howell, J Mercer

(1994), Vol. 110, pp. 37-47, Journal of Comparative Pathology, England, C1-1

journal article

Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels

J Paynter, A Grimes, P Lockhart, J Mercer

(1994), Vol. 351, pp. 186-190, FEBS Letters, England, C1-1

journal article
1993

Isolation of a partial candidate gene for Menkes disease by positional cloning

J Mercer, J Livingston, B Hall, J Paynter, C Begy, S Chandrasekharappa, P Lockhart, A Grimes, M Bhave, D Siemieniak, T Glover

(1993), Vol. 3, pp. 20-25, Nature Genetics, United States, C1-1

journal article
1992

Hepatic metallothionein gene expression in toxic milk mice

J Mercer, A Grimes, H Rauch

(1992), Vol. 122, pp. 1254-1259, Journal of Nutrition, United States, C1-1

journal article

MOLECULAR-BIOLOGY OF PROTEINS INVOLVED IN COPPER TRANSPORT

J MERCER, A GRIMES, J PAYNTER, P LOCKHART, M BHAVE

(1992), pp. 185-191, TRACE ELEMENTS : ROLES, RISKS AND REMEDIES, NEW ZEALAND, MASSEY UNIV, PALMERSTON NORTH, E1-1

conference
1991

Hepatic ceruloplasmin gene expression is unaltered in the toxic milk mouse

J Mercer, A Grimes, D Danks, H Rauch

(1991), Vol. 121, pp. 894-899, Journal of Nutrition, United States, C1-1

journal article

Cloning and characterization of cutE, a gene involved in copper transport in Escherichia coli

S Rogers, M Bhave, J Mercer, J Camakaris, B Lee

(1991), Vol. 173, pp. 6742-6748, Journal of Bacteriology, United States, C1-1

journal article

Developmental variation in copper, zinc and metallothionein mRNA in brindled mutant and nutritionally copper deficient mice

J Mercer, T Stevenson, S Wake, G Mitropoulos, J Camakaris, D Danks

(1991), Vol. 1097, pp. 205-211, BBA - Molecular Basis of Disease, Netherlands, C1-1

journal article
1990

Effects of cellular copper content on copper uptake and metallothionein and ceruloplasmin mRNA levels in mouse hepatocytes

H McArdle, J Mercer, A Sargeson, D Danks

(1990), Vol. 120, pp. 1370-1375, Journal of Nutrition, United States, C1-1

journal article

Analysis of hepatic copper, zinc, metallothionein and metallothionein‐Ia mRNA in developing sheep

J PAYNTER, J CAMAKARIS, J MERCER

(1990), Vol. 190, pp. 149-154, European Journal of Biochemistry, England, C1-1

journal article

The effect of d-penicillamine on metallothionein mRNA levels and copper distribution in mouse hepatocytes

H McArdle, P Kyriakou, A Grimes, J Mercer, D Danks

(1990), Vol. 75, pp. 315-324, Chemico-Biological Interactions, Ireland, C1-1

journal article
1989

Cloning and organization of bovine metallothionein genes

X Shen, W Yang, H Peng, M Peterson, J Mercer, S Woo

(1989), Vol. 34, pp. 953-956, Kexue tongbao, Scientia, C1-1

journal article

Phenylalanine hydroxylase gene haplotypes in Polynesians: Evolutionary origins and absence of alleles associated with severe phenylketonuria

M Hertzberg, K Jahromi, V Ferguson, H Dahl, J Mercer, K Mickleson, R Trent

(1989), Vol. 44, pp. 382-387, American Journal of Human Genetics, United States, C1-1

journal article

The effect of streptozotocin-induced diabetes on phenylalanine hydroxylase expression in rat liver

D Taylor, H Dahl, J Mercer, A Green, M Fisher

(1989), Vol. 264, pp. 185-190, Biochemical Journal, England, C1-1

journal article
1988

The sheep metallothionein gene family: Structure, sequence and evolutionary relationship of five linked genes

M PETERSON, F HANNAN, J MERCER

(1988), Vol. 174, pp. 417-424, European Journal of Biochemistry, England, C1-1

journal article

A total extract dot blot hybridization procedure for mRNA quantitation in small samples of tissues or cultured cells

A Grimes, H McArdle, J Mercer

(1988), Vol. 172, pp. 436-443, Analytical Biochemistry, United States, C1-1

journal article

The development of phenylalanine hydroxylase in rat liver; in vivo, and in vitro studies utilizing fetal hepatocyte cultures

G Yeoh, E Edkins, K Mackenzie, S Fuller, J Mercer, H Dahl

(1988), Vol. 38, pp. 42-48, Differentiation, England, C1-1

journal article

Differential expression of four linked sheep metallothionein genes

M PETERSON, J MERCER

(1988), Vol. 174, pp. 425-429, European Journal of Biochemistry, England, C1-1

journal article

Regulation of 5-aminolevulinate synthase mRNA in different rat tissues

G Srivastava, I Borthwick, D Maguire, C Elferink, M Bawden, J Mercer, B May

(1988), Vol. 263, pp. 5202-5209, Journal of Biological Chemistry, United States, C1-1

journal article
1987

Antithrombin III mRNA in adult rat liver and kidney and in rat liver during development

S D'Souza, J Mercer

(1987), Vol. 142, pp. 417-421, Biochemical and Biophysical Research Communications, United States, C1-1

journal article

Rat ceruloplasmin. Molecular cloning and gene expression in liver, choroid plexus, yolk sac, placenta, and testis.

A Aldred, A Grimes, G Schreiber, J Mercer

(1987), Vol. 262, pp. 2875-2878, Journal of Biological Chemistry, United States, C1-1

journal article

Stability of protein and mRNA in human postmortem liver-analysis by two-dimensional gel electrophoresis

J Finger, J Mercer, R Cotton, D Danks

(1987), Vol. 170, pp. 209-218, Clinica Chimica Acta, Netherlands, C1-1

journal article
1986

Structure and regulation of the sheep metallothionein‐Ia gene

M PETERSON, J MERCER

(1986), Vol. 160, pp. 579-585, European Journal of Biochemistry, England, C1-1

journal article

Variation in the amounts of hepatic copper, zinc and metallothionein mRNA during development in the rat

J Mercer, A Grimes

(1986), Vol. 238, pp. 23-27, Biochemical Journal, England, C1-1

journal article

A study of the role of metallothionein in the inherited copper toxicosis of dogs

D Hunt, S Wake, J Mercer, D Danks

(1986), Vol. 236, pp. 409-415, Biochemical Journal, England, C1-1

journal article

The W and L allelic forms of phenylalanine hydroxylase in the rat differ by a threonine to isoleucine substitution

J Mercer, W McAdam, G Chambers, I Walker

(1986), Vol. 236, pp. 679-683, Biochemical Journal, England, C1-1

journal article

Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites

H Dahl, J Mercer

(1986), Vol. 261, pp. 4148-4153, Journal of Biological Chemistry, United States, C1-1

journal article

Isolation of a human ceruloplasmin cDNA clone that includes the N-terminal leader sequence

J Mercer, A Grimes

(1986), Vol. 203, pp. 185-190, FEBS Letters, England, C1-1

journal article
1985

The Primary Structure of the Imported Mitochondrial Protein, Ornithine Transcarbamylase from Rat Liver: mRNA Levels During Ontogeny

P Mcintyre, L Graf, J Mercer, S Wake, P Hudson, N Hoogenraad

(1985), Vol. 4, pp. 147-156, DNA, United States, C1-1

journal article

An analysis of the rate of metallothionein mRNA poly(A)-shortening using RNA blot hybridization

J Mercer, S Wake

(1985), Vol. 13, pp. 7929-7943, Nucleic Acids Research, England, C1-1

journal article

Induction of metallothionein mRNA in rat liver and kidney after copper chloride injection

S Wake, J Mercer

(1985), Vol. 228, pp. 425-432, Biochemical Journal, England, C1-1

journal article
1984

Cloning and sequencing of a sheep metallothionein cDNA

M PETERSON, I LAZDINS, D DANKS, J MERCER

(1984), Vol. 143, pp. 507-511, European Journal of Biochemistry, England, C1-1

journal article

Two apparent molecular weight forms of human and monkey phenylalanine hydroxylase are due to phosphorylation

S Smith, B Kemp, W McAdam, J Mercer, R Cotton

(1984), Vol. 259, pp. 11284-11289, Journal of Biological Chemistry, United States, C1-1

journal article

Identification of two molecular-mass forms of phenylalanine hydroxylase that segregate independently in rats. Specific association of each form with certain rat strains

J Mercer, A Grimes, I Jennings, R Cotton

(1984), Vol. 219, pp. 891-898, Biochemical Journal, England, C1-1

journal article

A highly basic N-terminal extension of the mitochondrial matrix enzyme ornithine transcarbamylase from rat liver

P Mclntyre, L Graf, J Mercer, G Peterson, P Hudson, N Hoogenraad

(1984), Vol. 177, pp. 41-46, FEBS Letters, England, C1-1

journal article
1983

The two molecular weight forms of rat phenylalanine hydroxylase are encoded by different messenger RNAs

J Mercer, S Hunt, R Cotton

(1983), Vol. 258, pp. 5854-5857, Journal of Biological Chemistry, United States, C1-1

journal article
1982

Cloning of metallothionein cDNA from neonatal rat liver

J Mercer, P Hudson

(1982), Vol. 2, pp. 761-768, Bioscience Reports, England, C1-1

journal article

β-Hydroxyisobutyryl coenzyme A deacylase deficiency: A defect in valine metabolism associated with physical malformations

G Brown, S Hunt, R Scholem, K Fowler, A Grimes, J Mercer, R Truscott, R Cotton, J Rogers, D Danks

(1982), Vol. 70, pp. 532-538, Pediatrics, United States, C1-1

journal article
1981

Two new sulphur‐containing amino acids in man

R Truscott, D Malegan, E McCairns, B Halpern, J Hammond, R Cotton, J Mercer, S Hunt, J Rogers, D Danks

(1981), Vol. 8, pp. 99-104, Biological Mass Spectrometry, England, C1-1

journal article

Copper induction of translatable metallothionein messenger RNA

J Mercer, I Lazdins, T Stevenson, J Camakaris, D Danks

(1981), Vol. 1, pp. 793-800, Bioscience Reports, England, C1-1

journal article
1973

POLY(A) SEQUENCES IN PLANT POLYSOMAL RNA

T HIGGINS, J MERCER, P GOODWIN

(1973), Vol. 246, pp. 68-70, NATURE-NEW BIOLOGY, England, C1-1

journal article
1972

PEPTIDYL-DONOR SUBSTRATES FOR RIBOSOMAL PEPTIDYL TRANSFERASE - CHEMICAL SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-ACETYL AMINOACYL DI-NUCLEOTIDES AND TRI-NUCLEOTIDES

J MERCER, R SYMONS

(1972), Vol. 28, pp. 38-&, EUROPEAN JOURNAL OF BIOCHEMISTRY, England, C1-1

journal article
1971

USE OF N-ETHOXYCARBONYL-2-ETHOXY-1,2-DIHYDROQUINOLINE IN SELECTIVE N4-ACYLATION OF CYTIDINE AND ITS DERIVATIVES

J MERCER, R SYMONS

(1971), Vol. 238, pp. 27-&, BIOCHIMICA ET BIOPHYSICA ACTA, Netherlands, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

The Role of Amyloid Protein Precursor in Mammalian Copper Transport

Prof Ian Bush, Dr Robert Cherny, Prof Julian Mercer

ARC - Discovery Projects

  • 2008: $85,000
  • 2007: $85,000
  • 2006: $47,500

Copper Deficiency in Alzheimer's Disease

Prof James Camakaris, Prof Julian Mercer

NHMRC Project Grant

  • 2009: $43,200
  • 2008: $43,200
  • 2007: $44,700

Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein

Prof Ian Bush, Dr Robert Cherny, Prof Julian Mercer

ARC - Discovery Projects

  • 2011: $18,000
  • 2010: $19,000
  • 2009: $50,000

Protein networks mediating copper balance and their break-down in disease

A/Prof Sharon La Fontaine, Prof Julian Mercer, Prof James Camakaris, Prof Ann Hubbard

NHMRC Project Grant

  • 2010: $183,578
  • 2009: $180,157
  • 2008: $176,340

Copper pathways are altered in Parkinson's disease: Implications for cell vulnerability

A/Prof Kay Double, Prof Julian Mercer, A/Prof David Finkelstein

NHMRC Project Grant

  • 2012: $8,500

Other Public Sector Funding

NHMRC Equipment Grant 2011 - MMR SRC

Prof Julian Mercer, Prof Alister Ward

NHMRC - Equipment Grant (pre 2017)

  • 2011: $9,897

Industry and Other Funding

Establishment of a Biosensor Facility at the Centre for Cellular and Molecular Biology (CCMB), Deakin University, Burwood.

A/Prof Cenk Suphioglu, EmPr Leigh Ackland, A/Prof Sharon La Fontaine, Prof Julian Mercer

Clive and Vera Ramaciotti Foundation - Equipment Grant

  • 2011: $50,000

Establishment of a Flow Cytometry Facility at the Centre for Cellular and Molecular Biology, Deakin University

A/Prof Cenk Suphioglu, EmPr Leigh Ackland, A/Prof Sharon La Fontaine, Prof Julian Mercer

Clive and Vera Ramaciotti Foundation Grant - Research

  • 2010: $30,000

Detemining Pathogenic Effects of ATP7A Mutations in Distal Motor Neuropath

A/Prof Marina Kennerson, Prof Julian Mercer, A/Prof Sharon La Fontaine

US Muscular Dystrophy Association

  • 2015: $36,845
  • 2014: $47,431
  • 2013: $50,403
  • 2012: $46,500

Supervisions

Principal Supervisor
2014

Yiwen Fang

Thesis entitled: Novel mechanism of Col10a1 nonsense-mediated mRNA decay

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2013

William Singleton

Thesis entitled: Glutaredoxin and Glutathione regulate the activity of ATP7A AND ATP7B

Master of Science (Biology & Chemistry), School of Life and Environmental Sciences

2007

Bi Xia Ke

Thesis entitled: The Role of ATP7A in Copper Homeostasis

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2006

Alanna Castelli

Thesis entitled: Mutation Analysis of the Menkes Gene

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2005

Michael Cater

Thesis entitled: Mechanisms Regulating the Function of the ATP7B Copper-ATPase

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2004

Kenneth Dawson

Thesis entitled: Cystic Fibrosis in Children of the Eastern Arabian Peninsula

Doctor of Technology, School of Life and Environmental Sciences

2003

Natalie Barnes

Thesis entitled: Structure Function Studies of Mammalian Copper ATPases

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Associate Supervisor
2017

Yann Yap

Thesis entitled: Deciphering the molecular signaling cascade in rotenone-mediated neuronal death

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2013

David Freestone

Thesis entitled: Copper Homeostasis in Human Mammary Epithelial Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2012

Stephanie Materia

Thesis entitled: Quality Control Mechanisms Regulating the Copper-transporting ATPases ATP7A and ATP7B

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2010

Liza Bernadine Raymond

Thesis entitled: The Ikaros Gene Family: Characterisation of the `Atypical' Pegasus

Doctor of Philosophy (Medicine), School of Medicine

2007

Francois Monty

Thesis entitled: The Role of Copper Transport Proteins in the Small Intentestine

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Maree Bilandzic

Thesis entitled: Molecular Analysis of the Human Copper Uptake Protein hCTR1

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Christopher Lim

Thesis entitled: Identification of Proteins that Interact with the Copper Transporter ATP7B

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences