Prof Julian Mercer

STAFF PROFILE

Position

Emeritus Professor

Faculty

Faculty of Sci Eng & Built Env

Department

Faculty Office

Campus

Melbourne Burwood Campus

Contact

julian.mercer@deakin.edu.au
+61 3 925 17329

Publications

Filter by

2014

Copper pathology in vulnerable brain regions in Parkinson's disease

Katherine Davies, Sylvain Bohic, Asuncion Carmona, Richard Ortega, Veronica Cottam, Dominic Hare, John P. M. Finberg, Stefanie Reyes, Glenda Halliday, Prof Julian Mercer, A/Prof Kay Double

(2014), Vol. 36, pp. 858-866, Neurobiology of aging, Amsterdam, The Netherlands, C1

journal

Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation

Jarrod Wadwa, Yu-Hsiang Chu, Nhu Nguyen, Thomas Henson, Alyssa Figueroa, Dr Roxana Llanos, Dr Agnes Michalczyk, Hendrik Fullriede, Grant Brennan, Prof Julian Mercer, Prof Maria C Linder

(2014), Vol. 2, pp. 1-11, Physiological Reports, Oxford, United Kingdom, C1

journal

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

Dr Blaine Roberts, Nastasia K. H. Lim, Erin J McAllum, Dr Paul Stephen Donnelly, Dominic Hare, Philip Doble, Bradley J. Turner, Katherine Price, Sin Chun Lim, Brett M. Paterson, James Hickey, Timothy Rhoads, Jared Williams, Katja M. Kanninen, Lin Hung, Jeffrey R. Liddell, Alexandra Grubman, Mr Francois Monty, Dr Roxana Llanos, David Kramer, Prof Julian Mercer, Ashley I Bush, Colin L Masters, James Duce, Qiao-Xin Li, Joseph Beckman, Kevin J. Barnham, Anthony White, Peter J. Crouch

(2014), Vol. 34, pp. 8021-8031, Journal of neuroscience, Washington, D.C., C1

journal

Metabolism and functions of copper in brain

Ivo F. Scheiber, Prof Julian Mercer, Dr Ralf Dringen

(2014), Vol. 116, pp. 33-57, Progress in neurobiology, London, Eng., C1

journal
2013

Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons

Johnson J. Liu, Yaeseul Kim, Fang Yan, Qi Ding, Virginia Ip, Nancy N. Jong, Prof Julian Mercer, Mark J. McKeage

(2013), Vol. 85, pp. 207-215, Biochemical pharmacology, Amsterdam, The Netherlands, C1

journal

Copper transporting P-Type ATPases in the brain

Dr Sharon La Fontaine, Prof James Camakaris, Prof Julian Mercer

(2013), pp. 137-168, Brain diseases and metalloproteins, Boca Raton, Fla., B1-1

chapter

Localization of copper and copper transporters in the human brain

Katherine Davies, Dominic Hare, Veronica Cottam, Nicholas Chen, Leon Hilgers, Glenda Halliday, Prof Julian Mercer, A/Prof Kay Double

(2013), Vol. 5, pp. 43-51, Metallomics, Cambridge, England, C1

journal

Nonsense-mediated mRNA decay of collagen -emerging complexity in RNA surveillance mechanisms

Miss Yiwen Fang, John F. Bateman, Prof Julian Mercer, Dr Shireen Lamande

(2013), Vol. 126, pp. 2551-2560, Journal of cell science, Cambridge, England, C1

journal

Copper metabolism of astrocytes

Dr Ralf Dringen, Ivo F. Scheiber, Prof Julian Mercer

(2013), Vol. 5, pp. 1-4, Frontiers in aging neuroscience, Lausanne, Switzerland, C1

journal

Copper : effects of deficiency and overload

Ivo F. Scheiber, Dr Ralf Dringen, Prof Julian Mercer

(2013), pp. 359-387, Interrelations between essential metal ions and human diseases, Berlin, Germany, B1-1

chapter

Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase

Varadarajan Sudhahar, Norifumi Urao, Jin Oshikawa, Ronald D McKinney, Dr Roxana Llanos, Prof Julian Mercer, Masuko Ushio-Fukai, Tohru Fukai

(2013), Vol. 62, pp. 3839-3850, Diabetes, Alexandria, Va., C1-1

journal
2012

Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy

Ling Yi, Anthony Donsante, A/Prof Marina Kennerson, Prof Julian Mercer, James Y. Garbern, Stephen G. Kaler

(2012), Vol. 21, pp. 1794-1807, Human molecular genetics, Oxford, England, C1

journal

Clusterin and COMMD1 Independently Regulate Degradation of the Mammalian Copper ATPases ATP7A and ATP7B

Ms Stephanie Materia, Dr Michael Cater, Leo W. J. Klomp, Prof Julian Mercer, Dr Sharon La Fontaine

(2012), Vol. 287, pp. 2485-2499, Journal of biological chemistry, Bethesda, Md, United States, C1

journal

Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice

Yu-Ling Chu, Eric N. Sauble, Anthony Cabrera, Aleeza Roth, Prof Leigh Ackland, Prof Julian Mercer, Prof Maria C Linder

(2012), Vol. 25, pp. 373-382, BioMetals, Dordrecht, The Netherlands, C1

journal
2011

Clusterin (APOJ) : a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B

Ms Stephanie Materia, Dr Michael Cater, Leo W. J. Klomp, Prof Julian Mercer, Dr Sharon La Fontaine

(2011), Vol. 286, pp. 10073-10083, Journal of biological chemistry, Bethesda, Md., C1

journal
2010

Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue

Virginia Ip, Johnson J. Liu, Prof Julian Mercer, Mark J. McKeage

(2010), Vol. 6, pp. 1-10, Molecular pain, London, England, C1

journal

Copper accumulation by cultured astrocytes

Ivo F. Scheiber, Prof Julian Mercer, Dr Ralf Dringen

(2010), Vol. 56, pp. 451-460, Neurochemistry International, Oxford, England, C1

journal

Missense mutations in the copper transporter gene ATP7A cause X-Linked distal hereditary motor neuropathy

A/Prof Marina Kennerson, G. Nicholson, Stephen G. Kaler, Bartosz Kowalski, Prof Julian Mercer, Jingrong Tang, Dr Roxana Llanos, Shannon Chu, Reinaldo I Takata, Carlos E. Speck-Martins, Jonathan Baets, Leonardo Almeida-Souza, Dirk Fischer, Vincent Timmerman, Dr Philip Taylor, Steven S Scherer, Toby A. Ferguson, Thomas D. Bird, Peter De Jonghe, Shawna M. E. Feely, Michael E. Shy, James Y. Garbern

(2010), Vol. 86, pp. 342-352, American journal of human genetics, Cambridge, Mass., C1-1

journal

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B : emerging roles

Dr Sharon La Fontaine, Prof Leigh Ackland, Prof Julian Mercer

(2010), Vol. 42, pp. 206-209, International journal of biochemistry & cell biology, Oxford, England, C1

journal
2009

Neuronal expression of copper transporter 1 in rat dorsal root ganglia : association with platinum neurotoxicity

Johnson J. Liu, Stephen M. F. Jamieson, Joshuan Subramaniam, Virginia Ip, Nancy N. Jong, Prof Julian Mercer, Mark J. McKeage

(2009), Vol. 64, pp. 847-856, Cancer chemotherapy and pharmacology, Berlin, Germany, C1-1

journal
2008

Copper is taken up efficiently from albumin and α2-macroglobulin by cultured human cells by more than one mechanism

Mizue Moriya, Yi-Hsuan Ho, Anne Grana, Linh Nguyen, Arrissa Alvarez, Rita Jamil, Prof Leigh Ackland, Dr Agnes Michalczyk, Pia Hamer, Danny Ramos, Stephen Kim, Prof Julian Mercer, Prof Maria C Linder

(2008), Vol. 295, pp. 708-721, American journal of physiology: cell physiology, Bethesda, Md., C1

journal

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

Dr Michael Cater, Miss Kelly McInnes, Qiao-Xin Li, Irene Volitakis, Dr Sharon La Fontaine, Prof Julian Mercer, Ashley I Bush

(2008), Vol. 412, pp. 141-152, Biochemical journal, London, England, C1-1

journal

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

Tai Du, Dr Sharon La Fontaine, Michael Abdo, Shayne A. Bellingham, Mark Greenough, Irene Volitakis, Dr Robert Cherny, Ashley I Bush, Mr Peter Hudson, Prof James Camakaris, Prof Julian Mercer, Peter J. Crouch, Colin L Masters, Victoria M. Perreau, Anthony White

(2008), Vol. 8, pp. 1819-1831, Proteomics, Weinheim, Germany, C1-1

journal

ATP7A transgenic and nontransgenic mice are resistant to high copper exposure

Bi Xia Ke, Dr Roxana Llanos, Prof Julian Mercer

(2008), Vol. 138, pp. 693-697, Journal of nutrition, Bethesda, Md., C1-1

journal
2007

Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson Protein (ATP7B)

Dr Michael Cater, Dr Sharon La Fontaine, Prof Julian Mercer

(2007), Vol. 401, pp. 143-153, Biochemical journal, London, England, C1

journal

Copper-transporting P-Type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer

Satsuki Owatari, Satoshi Akune, Masaharu Komatsu, Ryuji Ikeda, Stephen Firth, Xiao-Fang Che, Masatatsu Yamamoto, Kazutake Tsujikawa, Masaki Kitazono, Takashi Ishizawa, Toru Takeuchi, Talashi Aikou, Prof Julian Mercer, Shin-ichi Akiyama, Tatsuhiko Furukawa

(2007), Vol. 67, pp. 4860-4868, Cancer research, Philadelphia, Pa., C1

journal

Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A)

Ya Hui Hung, Meredith J Layton, Ilia Voskoboinik, Prof Julian Mercer, Prof James Camakaris

(2007), Vol. 401, pp. 569-579, Biochemical journal, London, England, C1

journal

Trafficking of the copper-ATPases, ATP7A and ATP7B: Role in copper homeostasis

Dr Sharon La Fontaine, Prof Julian Mercer

(2007), Vol. 463, pp. 149-167, Archives of biochemistry and biophysics, Amsterdam, The Netherlands, C1

journal

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental Cells

Ms Belinda Mary Hardman, Dr Agnes Michalczyk, Mark Greenough, Prof James Camakaris, Prof Julian Mercer, Prof Leigh Ackland

(2007), Vol. 20, pp. 1073-1084, Cellular physiology and biochemistry, Basel, Switzerland, C1

journal

Heterozygous tx mice have an increased sensitivity to copper loading: implications for Wilson's Disease carriers

Daphne M.Y. Cheah, Yolanda Deal, Paul F A Wright, Nicole E. Buck, Chung Wo Chow, Prof Julian Mercer, Dr Katrina Allen

(2007), Vol. 20, pp. 751-757, BioMetals, Amsterdam, The Netherlands, C1

journal

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells

Ms Belinda Mary Hardman, Dr Agnes Michalczyk, Mark Greenough, Prof James Camakaris, Prof Julian Mercer, Prof Leigh Ackland

(2007), Vol. 402, pp. 241-250, Biochemical journal, London, England, C1

journal
2006

Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading

Dr Katrina Allen, Nicole E. Buck, Daphne M.Y. Cheah, Sophie Gazeas, Prithi Bhathal, Prof Julian Mercer

(2006), Vol. 19, pp. 555-564, BioMetals, Amsterdam, The Netherlands, C1

journal

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

Dr Chris Lim, Dr Michael Cater, Prof Julian Mercer, Dr Sharon La Fontaine

(2006), Vol. 348, pp. 428-436, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal

Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A

Dr Chris Lim, Dr Michael Cater, Prof Julian Mercer, Dr Sharon La Fontaine

(2006), Vol. 281, pp. 14006-14014, Journal of biological chemistry, Bethesda, Md, C1

journal

Copper in mammals: mechanisms of homeostasis and pathophysiology

Dr Michael Cater, Prof Julian Mercer

(2006), pp. 101-120, Molecular biology of metal homeostasis and detoxification : from microbes to man, Berlin, Germany, B1

chapter
2005

Copper exposure induces trafficking of the Menkes protein in intestinal epithelium of ATP7A transgenic mice

Mr Francois Monty, Dr Roxana Llanos, Prof Julian Mercer, Dr David Kramer

(2005), Vol. 135, pp. 2762-2766, Journal of nutrition, Bethesda, Md., C1

journal
2004

Liver cell transplantation leads to repopulation and functional correction in a mouse model of Wilson's disease

Dr Katrina Allen, Daphne M.Y. Cheah, Paul F A Wright, Sophie Gazeas, Nicole E Pettigrew-Buck, Yolanda Deal, Prof Julian Mercer, Robert Williamson

(2004), Vol. 19, pp. 1283-1290, Journal of gastroenterology and hepatology, New York, NY., C1

journal

Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites

Dr Michael Cater, John Forbes, Dr Sharon La Fontaine, Diane Cox, Prof Julian Mercer

(2004), Vol. 380, pp. 805-813, Biochemical journal, London, England, C1

journal
2003

Copper-induced trafficking of the Cu-ATPase: a key mechanism for copper homeostasis

Prof Julian Mercer

(2003), Vol. 16, pp. 175-184, BioMetals, Amsterdam, The Netherlands, C1

journal

Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein

Dr Daniel Strausak, Michelle Howie, Stephen Firth, Andrea Schlicksupp, Rudiger Pipkorn, Gerd Multhaup, Prof Julian Mercer

(2003), Vol. 278, pp. 20821-20827, Journal of biological chemistry, Baltimore, Md., C1

journal

Molecular and cellular aspects of copper transport in developing mammals

Prof Julian Mercer, Dr Roxana Llanos

(2003), Vol. 133, pp. 1481S-1484S, Journal of nutrition, Bethesda, Md., C1

journal

Endosomal trafficking of the Menkes copper ATPase ATP7A is mediated by vesicles containing the Rab7 and Rab5 GTPase proteins

M.C Pascale, S Franceschelli, O Moltedo, F Belleudi, M.R Torrisi, C Bucci, Dr Sharon La Fontaine, Prof Julian Mercer, A Leone

(2003), Vol. 291, pp. 377-385, Experimental cell research, San Diego, Calif, C1

journal

Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

Dr David Kramer, Dr Roxana Llanos, Prof Julian Mercer

(2003), pp. 207-244, Metal ions and neurodegenerative disorders, Singapore, B1

chapter
2002

Molecular basis of diseases of copper homeostasis

Prof Julian Mercer, Dr David Kramer, Prof James Camakaris

(2002), pp. 249-276, Handbook of copper pharmacology and toxicology, Totowa, N.J., B1

chapter

The molecular basis of copper homeostasis and copper-related disorders

Dr Roxana Llanos, Prof Julian Mercer

(2002), Vol. 21, pp. 259-270, DNA and cell biology, New York, N.Y., C1

journal

Correction of the copper transport defect of Menkes patient fibroblasts by expression of two forms of the sheep Wilson ATPase

Paul Lockhart, Dr Sharon La Fontaine, Stephen Firth, Mark Greenough, Prof James Camakaris, Prof Julian Mercer

(2002), Vol. 1588, pp. 189-194, Biochimica et biophysica acta (BBA) - molecular basis of disease, Netherlands, C1

journal

Copper-regulated trafficking of the Menkes disease copper ATPase associated with formation of a phosphorylated catalytic intermediate

Dr Michael Petris, Ilia Voskoboinik, Dr Michael Cater, Kathryn Smith, Byung-Eun Kim, Dr Roxana Llanos, Dr Daniel Strausak, Prof James Camakaris, Prof Julian Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Baltimore, Md., C1

journal

Understanding the mechanism and function of copper P-type ATPases

Ilia Voskoboinik, Prof James Camakaris, Prof Julian Mercer

(2002), pp. 123-150, Copper-containing proteins, San Diego, Calif., B1

chapter
2001

Functional studies on the Wilson copper P-Type ATPase and toxic milk mouse mutant

Ilia Voskoboinik, Mark Greenough, Dr Sharon La Fontaine, Prof Julian Mercer, Prof James Camakaris

(2001), Vol. 281, pp. 966-970, Biochemical and biophysical research communications, San Diego, Calif, C1

journal

Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copperATPase

Dr Sharon La Fontaine, Dr Michael Theophilos, Stephen Firth, Robert Gould, Prof Robert Parton, Prof Julian Mercer

(2001), Vol. 10, pp. 361-370, Human molecular genetics, Oxford, England, C1

journal

Functional analysis of the sheep Wilson disease protein (sATP7B) in CHO cells

Paul Lockhart, Prof Julian Mercer

(2001), Vol. 80, pp. 349-357, European journal of cell biology, Amsterdam, The Netherlands, C1

journal

Copper in disorders with neurological symptoms: Alzheimer`s, Menkes, and Wilson Diseases

Dr Daniel Strausak, Prof Julian Mercer, Hermann H. Dieter, Wolfgang Stremmel, Gerd Multhaup

(2001), Vol. 55, pp. 175-185, Brain research bulletin, New York, NY, C1

journal

The molecular basis of copper-transport diseases

Prof Julian Mercer

(2001), Vol. 7, pp. 64-69, Trends in molecular medicine, New York, N.Y., C1

journal