Prof Julian Mercer

STAFF PROFILE

Position

Emeritus Professor

Faculty

Faculty of Sci Eng & Built Env

Department

Faculty Office

Campus

Melbourne Burwood Campus

Contact

julian.mercer@deakin.edu.au
+61 3 925 17329

Publications

Filter by

2016

Copper dyshomoeostasis in Parkinson's disease: implications for pathogenesis and indications for novel therapeutics

K Davies, J Mercer, N Chen, K Double

(2016), Vol. 130, pp. 565-574, Clinical science, London, Eng., C1

journal

Characterizing the molecular phenotype of an Atp7a(T985I) conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX)

G Perez-Siles, A Grant, M Ellis, C Ly, A Kidambi, M Khalil, R Llanos, S La Fontaine, A Strickland, S Züchner, S Bermeo, E Neist, T Brennan-Speranza, R Takata, C Speck-Martins, J Mercer, G Nicholson, M Kennerson

(2016), pp. 981-882, Metallomics: integrated biometal science, Cambridge, Eng., C1

journal
2014

Copper pathology in vulnerable brain regions in Parkinson's disease

K Davies, S Bohic, A Carmona, R Ortega, V Cottam, D Hare, J Finberg, S Reyes, G Halliday, J Mercer, K Double

(2014), Vol. 36, pp. 858-866, Neurobiology of aging, Amsterdam, The Netherlands, C1

journal

Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation

J Wadwa, Y Chu, N Nguyen, T Henson, A Figueroa, R Llanos, M Ackland, A Michalczyk, H Fullriede, G Brennan, J Mercer, M Linder

(2014), Vol. 2, pp. 1-11, Physiological Reports, Oxford, United Kingdom, C1

journal

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

B Roberts, N Lim, E McAllum, P Donnelly, D Hare, P Doble, B Turner, K Price, S Lim, B Paterson, J Hickey, T Rhoads, J Williams, K Kanninen, L Hung, J Liddell, A Grubman, J Monty, R Llanos, D Kramer, J Mercer, A Bush, C Masters, J Duce, Q Li, J Beckman, K Barnham, A White, P Crouch

(2014), Vol. 34, pp. 8021-8031, Journal of neuroscience, Washington, D.C., C1

journal

Metabolism and functions of copper in brain

I Scheiber, J Mercer, R Dringen

(2014), Vol. 116, pp. 33-57, Progress in neurobiology, London, Eng., C1

journal
2013

Copper transporting P-Type ATPases in the brain

S La Fontaine, J Camakaris, J Mercer

(2013), pp. 137-168, Brain diseases and metalloproteins, Boca Raton, Fla., B1-1

chapter

Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons

J Liu, Y Kim, F Yan, Q Ding, V Ip, N Jong, J Mercer, M McKeage

(2013), Vol. 85, pp. 207-215, Biochemical pharmacology, Amsterdam, The Netherlands, C1

journal

Localization of copper and copper transporters in the human brain

K Davies, D Hare, V Cottam, N Chen, L Hilgers, G Halliday, J Mercer, K Double

(2013), Vol. 5, pp. 43-51, Metallomics, Cambridge, England, C1

journal

Nonsense-mediated mRNA decay of collagen -emerging complexity in RNA surveillance mechanisms

Y Fang, J Bateman, J Mercer, S Lamande

(2013), Vol. 126, pp. 2551-2560, Journal of cell science, Cambridge, England, C1

journal

Copper metabolism of astrocytes

R Dringen, I Scheiber, J Mercer

(2013), Vol. 5, pp. 1-4, Frontiers in aging neuroscience, Lausanne, Switzerland, C1

journal

Copper : effects of deficiency and overload

I Scheiber, R Dringen, J Mercer

(2013), pp. 359-387, Interrelations between essential metal ions and human diseases, Berlin, Germany, B1-1

chapter

Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase

V Sudhahar, N Urao, J Oshikawa, R McKinney, R Llanos, J Mercer, M Ushio-Fukai, T Fukai

(2013), Vol. 62, pp. 3839-3850, Diabetes, Alexandria, Va., C1-1

journal
2012

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B

S Materia, M Cater, L Klomp, J Mercer, S La Fontaine

(2012), Vol. 287, pp. 2485-2499, Journal of biological chemistry, Bethesda, Md., C1

journal

Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy

L Yi, A Donsante, M Kennerson, J Mercer, J Garbern, S Kaler

(2012), Vol. 21, pp. 1794-1807, Human molecular genetics, Oxford, England, C1

journal

Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice

Y Chu, E Sauble, A Cabrera, A Roth, M Ackland, J Mercer, M Linder

(2012), Vol. 25, pp. 373-382, BioMetals, Dordrecht, The Netherlands, C1

journal
2011

Clusterin (APOJ) : a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B

S Materia, M Cater, L Klomp, J Mercer, S La Fontaine

(2011), Vol. 286, pp. 10073-10083, Journal of biological chemistry, Bethesda, Md., C1

journal
2010

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B : emerging roles

S La Fontaine, M Ackland, J Mercer

(2010), Vol. 42, pp. 206-209, International journal of biochemistry & cell biology, Oxford, England, C1

journal

Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B

W Singleton, K McInnes, M Cater, W Winnall, R McKirdy, Y Yu, P Taylor, B Ke, D Richardson, J Mercer, S La Fontaine

(2010), Vol. 285, pp. 27111-27121, Journal of biological chemistry, Bethesda, Md., C1

journal

Copper accumulation by cultured astrocytes

I Scheiber, J Mercer, R Dringen

(2010), Vol. 56, pp. 451-460, Neurochemistry International, Oxford, England, C1

journal

Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue

V Ip, J Liu, J Mercer, M McKeage

(2010), Vol. 6, pp. 1-10, Molecular pain, London, England, C1

journal

Missense mutations in the copper transporter gene ATP7A cause X-Linked distal hereditary motor neuropathy

M Kennerson, G Nicholson, S Kaler, B Kowalski, J Mercer, J Tang, R Llanos, S Chu, R Takata, C Speck-Martins, J Baets, L Almeida-Souza, D Fischer, V Timmerman, P Taylor, S Scherer, T Ferguson, T Bird, P De Jonghe, S Feely, M Shy, J Garbern

(2010), Vol. 86, pp. 342-352, American journal of human genetics, Cambridge, Mass., C1-1

journal
2009

Neuronal expression of copper transporter 1 in rat dorsal root ganglia : association with platinum neurotoxicity

J Liu, S Jamieson, J Subramaniam, V Ip, N Jong, J Mercer, M McKeage

(2009), Vol. 64, pp. 847-856, Cancer chemotherapy and pharmacology, Berlin, Germany, C1-1

journal
2008

ATP7B expression in human breast epithelial cells is mediated by lactational hormones

A Michalczyk, E Bastow, M Greenough, J Camakaris, D Freestone, P Taylor, M Linder, J Mercer, M Ackland

(2008), Vol. 56, pp. 389-399, Journal of histochemistry and cytochemistry, Seattle, Wash., C1

journal

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

R Llanos, A Michalczyk, D Freestone, S Currie, M Linder, M Ackland, J Mercer

(2008), Vol. 372, pp. 613-617, Biochemical and biophysical research communications, San Diego, Calif., C1

journal

Copper is taken up efficiently from albumin and ?2-macroglobulin by cultured human cells by more than one mechanism

M Moriya, Y Ho, A Grana, L Nguyen, A Alvarez, R Jamil, M Ackland, A Michalczyk, P Hamer, D Ramos, S Kim, J Mercer, M Linder

(2008), Vol. 295, pp. 708-721, American journal of physiology: cell physiology, Bethesda, Md., C1

journal

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

M Cater, K McInnes, Q Li, I Volitalis, S La Fontaine, J Mercer, A Bush

(2008), Vol. 412, pp. 141-152, Biochemical journal, London, England, C1-1

journal

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

T Du, S La Fontaine, M Abdo, S Bellingham, M Greenough, I Volitakis, R Cherny, A Bush, P Hudson, J Camakaris, J Mercer, P Crouch, C Masters, V Perreau, A White

(2008), Vol. 8, pp. 1819-1831, Proteomics, Weinheim, Germany, C1-1

journal

ATP7A transgenic and nontransgenic mice are resistant to high copper exposure

B Ke, R Llanos, J Mercer

(2008), Vol. 138, pp. 693-697, Journal of nutrition, Bethesda, Md., C1-1

journal
2007

Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson Protein (ATP7B)

M Cater, S La Fontaine, J Mercer

(2007), Vol. 401, pp. 143-153, Biochemical journal, London, England, C1

journal

Copper-transporting P-Type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer

S Owatari, S Akune, M Komatsu, R Ikeda, S Firth, X Che, M Yamamoto, K Tsujikawa, M Kitazono, T Ishizawa, T Takeuchi, T Aikou, J Mercer, S Akiyama, T Furukawa

(2007), Vol. 67, pp. 4860-4868, Cancer research, Philadelphia, Pa., C1

journal

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells

B Hardman, A Michalczyk, M Greenough, J Camakaris, J Mercer, L Ackland

(2007), Vol. 402, pp. 241-250, Biochemical journal, London, England, C1

journal

Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A)

Y Hung, M Layton, I Voskoboinik, J Mercer, J Camakaris

(2007), Vol. 401, pp. 569-579, Biochemical journal, London, England, C1

journal

Trafficking of the copper-ATPases, ATP7A and ATP7B: Role in copper homeostasis

S La Fontaine, J Mercer

(2007), Vol. 463, pp. 149-167, Archives of biochemistry and biophysics, Amsterdam, The Netherlands, C1

journal

Heterozygous tx mice have an increased sensitivity to copper loading: implications for Wilson's Disease carriers

D Cheah, Y Deal, P Wright, N Buck, C Chow, J Mercer, K Allen

(2007), Vol. 20, pp. 751-757, BioMetals, Amsterdam, The Netherlands, C1

journal

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental Cells

B Hardman, A Michalczyk, M Greenough, J Camakaris, J Mercer, L Ackland

(2007), Vol. 20, pp. 1073-1084, Cellular physiology and biochemistry, Basel, Switzerland, C1

journal
2006

Copper in mammals: mechanisms of homeostasis and pathophysiology

M Cater, J Mercer

(2006), pp. 101-120, Molecular biology of metal homeostasis and detoxification : from microbes to man, Berlin, Germany, B1

chapter

Correction of a mouse model of Menkes disease by the human Menkes gene

R Llanos, B Ke, M Wright, Y Deal, F Monty, D Kramer, J Mercer

(2006), Vol. 1762, pp. 485-493, Biochimica et biophysica acta (BBA) - molecular basis of disease, Amsterdam, The Netherlands, C1

journal

Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells

B Hardman, U Manuelpillai, E Wallace, J Monty, D Kramer, Y Kuo, J Mercer, L Ackland

(2006), Vol. 27, pp. 968-977, Placenta, London, England, C1

journal

Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A

C Lim, M Cater, J Mercer, S La Fontaine

(2006), Vol. 281, pp. 14006-14014, Journal of biological chemistry, Bethesda, Md, C1

journal

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

C Lim, M Cater, J Mercer, S La Fontaine

(2006), Vol. 348, pp. 428-436, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal

Alteration of copper physiology in mice overexpressing the human menkes protein ATP7A

B Ke, R Llanos, M Wright, Y Deal, J Mercer

(2006), Vol. 290, pp. 1460-1467, American journal of physiology : regulatory, interative comparative physiology, Bethesda, Md., C1

journal

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

M Cater, S La Fontaine, K Shield, Y Deal, J Mercer

(2006), Vol. 130, pp. 493-506, Gastroenterology, Amsterdam, Nertherlands, C1

journal

Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading

K Allen, N Buck, D Cheah, S Gazeas, P Bhathal, J Mercer

(2006), Vol. 19, pp. 555-564, BioMetals, Amsterdam, The Netherlands, C1

journal
2005

Copper exposure induces trafficking of the Menkes protein in intestinal epithelium of ATP7A transgenic mice

J Monty, R Llanos, J Mercer, D Kramer

(2005), Vol. 135, pp. 2762-2766, Journal of nutrition, Bethesda, Md., C1

journal

A single PDZ domain protein interacts with the menkes copper ATPase, ATP7A : a new protein implicated in copper homeostasis

S Stephenson, D Dubach, C Lim, J Mercer, S La Fontaine

(2005), Vol. 280, pp. 33270-33279, Journal of biological chemistry, Baltimore, Md, C1-1

journal
2004

Expression and localization of Menkes and Wilson copper transporting ATPases in human placenta

B Hardman, U Manuelpillai, E Wallace, S van de Waasenburg, M Cater, J Mercer, L Ackland

(2004), Vol. 25, pp. 512-517, Placenta, Amsterdam, Netherlands, C1

journal

Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites

M Cater, J Forbes, S La Fontaine, D Cox, J Mercer

(2004), Vol. 380, pp. 805-813, Biochemical journal, London, England, C1

journal

Liver cell transplantation leads to repopulation and functional correction in a mouse model of Wilson's disease

K Allen, D Cheah, P Wright, S Gazeas, N Pettigrew-Buck, Y Deal, J Mercer, R Williamson

(2004), Vol. 19, pp. 1283-1290, Journal of gastroenterology and hepatology, New York, NY., C1

journal
2003

Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

D Kramer, R Llanos, J Mercer

(2003), pp. 207-244, Metal ions and neurodegenerative disorders, Singapore, B1

chapter

Molecular and cellular aspects of copper transport in developing mammals

J Mercer, R Llanos

(2003), Vol. 133, Journal of nutrition, Bethesda, Md., C1

journal

Copper-induced trafficking of the Cu-ATPase: a key mechanism for copper homeostasis

J Mercer, N Barnes, J Stevenson, D Strausak, R Llanos

(2003), Vol. 16, pp. 175-184, BioMetals, Amsterdam, The Netherlands, C1

journal

Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein

D Strausak, M Howie, S Firth, A Schlicksupp, R Pipkorn, G Multhaup, J Mercer

(2003), Vol. 278, pp. 20821-20827, Journal of biological chemistry, Baltimore, Md., C1

journal

Endosomal trafficking of the Menkes copper ATPase ATP7A is mediated by vesicles containing the Rab7 and Rab5 GTPase proteins

M Pascale, S Franceschelli, O Moltedo, F Belleudi, M Torrisi, C Bucci, S La Fontaine, J Mercer, A Leone

(2003), Vol. 291, pp. 377-385, Experimental cell research, San Diego, Calif, C1

journal
2002

Molecular basis of diseases of copper homeostasis

J Mercer, D Kramer, J Camakaris

(2002), pp. 249-276, Handbook of copper pharmacology and toxicology, Totowa, N.J., B1

chapter

Correction of the copper transport defect of Menkes patient fibroblasts by expression of two forms of the sheep Wilson ATPase

P Lockhart, S La Fontaine, S Firth, M Greenough, J Camakaris, J Mercer

(2002), Vol. 1588, pp. 189-194, Biochimica et biophysica acta (BBA) - molecular basis of disease, Netherlands, C1

journal

The molecular basis of copper homeostasis and copper-related disorders

R Llanos, J Mercer

(2002), Vol. 21, pp. 259-270, DNA and cell biology, New York, N.Y., C1

journal

Understanding the mechanism and function of copper P-type ATPases

I Voskoboinik, J Camakaris, J Mercer

(2002), pp. 123-150, Copper-containing proteins, San Diego, Calif., B1

chapter

Copper-regulated trafficking of the Menkes disease copper ATPase associated with formation of a phosphorylated catalytic intermediate

M Petris, I Voskoboinik, M Cater, K Smith, B Kim, R Llanos, D Strausak, J Camakaris, J Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Baltimore, Md., C1

journal
2001

The molecular basis of copper-transport diseases

J Mercer

(2001), Vol. 7, pp. 64-69, Trends in molecular medicine, New York, N.Y., C1

journal

Functional analysis of the sheep Wilson disease protein (sATP7B) in CHO cells

P Lockhart, J Mercer

(2001), Vol. 80, pp. 349-357, European journal of cell biology, Amsterdam, The Netherlands, C1

journal

Copper in disorders with neurological symptoms: Alzheimer`s, Menkes, and Wilson Diseases

D Strausak, J Mercer, H Dieter, W Stremmel, G Multhaup

(2001), Vol. 55, pp. 175-185, Brain research bulletin, New York, NY, C1

journal

Effect of the toxic milk mutation (tx) on the function and intracellular localization of Wnd, the murine homologue of the Wilson copperATPase

S La Fontaine, M Theophilos, S Firth, R Gould, R Parton, J Mercer

(2001), Vol. 10, pp. 361-370, Human molecular genetics, Oxford, England, C1

journal

Functional studies on the Wilson copper P-Type ATPase and toxic milk mouse mutant

I Voskoboinik, M Greenough, S La Fontaine, J Mercer, J Camakaris

(2001), Vol. 281, pp. 966-970, Biochemical and biophysical research communications, San Diego, Calif, C1

journal

Funded Projects at Deakin

Australian Competitive Grants

The Role of Amyloid Protein Precursor in Mammalian Copper Transport

Prof Ian Bush, Dr Robert Cherny, Prof Julian Mercer

ARC - Discovery Projects

  • 2008: $85,000
  • 2007: $85,000
  • 2006: $47,500

Copper Deficiency in Alzheimer's Disease

Prof James Camakaris, Prof Julian Mercer

NHMRC Project Grant

  • 2009: $43,200
  • 2008: $43,200
  • 2007: $44,700

Neural Copper Homeostasis: the role of the Alzheimer Amyloid-beta Precursor Protein

Prof Ian Bush, Dr Robert Cherny, Prof Julian Mercer

ARC - Discovery Projects

  • 2011: $18,000
  • 2010: $19,000
  • 2009: $50,000

Protein networks mediating copper balance and their break-down in disease

Dr Sharon La Fontaine, Prof Julian Mercer, Prof James Camakaris, Prof Ann Hubbard

NHMRC Project Grant

  • 2010: $183,578
  • 2009: $180,157
  • 2008: $176,340

Copper pathways are altered in Parkinson's disease: Implications for cell vulnerability

A/Prof Kay Double, Prof Julian Mercer, A/Prof David Finkelstein

NHMRC Project Grant

  • 2012: $8,500

Other Public Sector Funding

NHMRC Equipment Grant 2011 - MMR SRC

Prof Julian Mercer, Prof Alister Ward

  • 2011: $9,897

Industry and Other Funding

Establishment of a Biosensor Facility at the Centre for Cellular and Molecular Biology (CCMB), Deakin University, Burwood.

A/Prof Cenk Suphioglu, Prof Leigh Ackland, Dr Sharon La Fontaine, Prof Julian Mercer

  • 2011: $50,000

Establishment of a Flow Cytometry Facility at the Centre for Cellular and Molecular Biology, Deakin University

A/Prof Cenk Suphioglu, Prof Leigh Ackland, Dr Sharon La Fontaine, Prof Julian Mercer

  • 2010: $30,000

Detemining Pathogenic Effects of ATP7A Mutations in Distal Motor Neuropath

A/Prof Marina Kennerson, Prof Julian Mercer, Dr Sharon La Fontaine

  • 2015: $36,845
  • 2014: $47,431
  • 2013: $50,403
  • 2012: $46,500

Supervisions

Principal Supervisor
2014

Yiwen Fang

Thesis entitled: Novel mechanism of Col10a1 nonsense-mediated mRNA decay

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2013

William Singleton

Thesis entitled: Glutaredoxin and Glutathione regulate the activity of ATP7A AND ATP7B

Master of Science (Biology & Chemistry), School of Life and Environmental Sciences

2007

Bi Xia Ke

Thesis entitled: The Role of ATP7A in Copper Homeostasis

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2006

Alanna Castelli

Thesis entitled: Mutation Analysis of the Menkes Gene

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2005

Michael Cater

Thesis entitled: Mechanisms Regulating the Function of the ATP7B Copper-ATPase

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2004

Kenneth Dawson

Thesis entitled: Cystic Fibrosis in Children of the Eastern Arabian Peninsula

Doctor of Technology, School of Life and Environmental Sciences

2003

Natalie Barnes

Thesis entitled: Structure Function Studies of Mammalian Copper ATPases

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Associate Supervisor
2017

Yann Yap

Thesis entitled: Deciphering the molecular signaling cascade in rotenone-mediated neuronal death

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2013

David Freestone

Thesis entitled: Copper Homeostasis in Human Mammary Epithelial Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2012

Stephanie Materia

Thesis entitled: Quality Control Mechanisms Regulating the Copper-transporting ATPases ATP7A and ATP7B

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2010

Liza John

Thesis entitled: The Ikaros Gene Family: Characterisation of the `Atypical' Pegasus

Doctor of Philosophy (Medicine), School of Medicine

2007

Francois Monty

Thesis entitled: The Role of Copper Transport Proteins in the Small Intentestine

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Maree Bilandzic

Thesis entitled: Molecular Analysis of the Human Copper Uptake Protein hCTR1

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Christopher Lim

Thesis entitled: Identification of Proteins that Interact with the Copper Transporter ATP7B

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences