Dr Julie Sharp

STAFF PROFILE

Position

Senior Research Fellow

Faculty

Instit for Frontier Materials

Department

Instit for Frontier Materials

Campus

Geelong Waurn Ponds Campus

Contact

julie.sharp@deakin.edu.au
+61 3 522 71180

Publications

Filter by

2017

Hormonal regulation of platypus Beta-lactoglobulin and monotreme lactation protein genes

A Enjapoori, C Lefevre, K Nicholas, J Sharp

(2017), Vol. 242, pp. 38-48, General and comparative endocrinology, Amsterdam, The Netherlands, C1

journal

The tammar wallaby: a marsupial model to examine the timed delivery and role of bioactives in milk

J Sharp, S Wanyonyi, V Modepalli, A Watt, S Kuruppath, L Hinds, A Kumar, H Abud, C Lefevre, K Nicholas

(2017), Vol. 244, pp. 164-177, General and comparative endocrinology, Amsterdam, The Netherlands, C1

journal

Dimeric but not monomeric ?-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells

J Sharp, A Brennan, G Polekhina, D Ascher, C Lefevre, K Nicholas

(2017), Vol. 33, pp. 86-97, Cellular signalling, Amsterdam, The Netherlands, C1

journal

Argon gas plasma to decontaminate and extend shelf life of milk

S Ponraj, J Sharp, J Kanwar, A Sinclair, L Kviz, K Nicholas, X Dai

(2017), pp. 1-8, Plasma processes and polymers, Chichester, Eng., C1

journal

Human milk bioactivity: lessons from the evolution of lactation

J Sharp, A Watt, C Lefevre, K Nicholas

(2017), Vol. 48, pp. 13-18, Australian biochemist, Kent Town, S. Aust., C1

journal
2016

Analysis of human breast milk cells: gene expression profiles during pregnancy, lactation, involution, and mastitic infection

J Sharp, C Lefèvre, A Watt, K Nicholas

(2016), Vol. 16, pp. 297-321, Functional and integrative genomics, Berlin, Germany, C1

journal

Marsupial tammar wallaby delivers milk bioactives to altricial pouch young to support lung development

V Modepalli, L Hinds, J Sharp, C Lefevre, K Nicholas

(2016), Vol. 142, pp. 22-29, Mechanisms of development, Amsterdam, The Netherlands, C1

journal
2015

Role of marsupial tammar wallaby milk in lung maturation of pouch young.

V Modepalli, L Hinds, J Sharp, C Lefevre, K Nicholas

(2015), Vol. 15, pp. 16-16, BMC Developmental Biology, England, C1

journal

Bioactive functions of milk proteins: a comparative genomics approach

J Sharp, V Modepalli, A Enjapoori, S Bisana, H Abud, C Lefevre, K Nicholas

(2015), Vol. 19, pp. 289-302, Journal of mammary gland biology and neoplasia, Berlin, Germany, C1

journal
2014

Monotreme lactation protein is highly expressed in monotreme milk and provides antimicrobial protection

A Enjapoori, T Grant, S Nicol, C Lefèvre, K Nicholas, J Sharp

(2014), Vol. 6, pp. 2754-2773, Genome biology and evolution, Oxford, England, C1

journal

Comparative analysis of caveolins in mouse and tammar wallaby: role in regulating mammary gland function

S Kuruppath, J Sharp, C Lefevre, R Murphy, K Nicholas

(2014), Vol. 552, pp. 51-58, Gene, Amsterdam , Netherlands, C1

journal

Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii)

V Modepalli, A Kumar, L Hinds, J Sharp, K Nicholas, C Lefevre

(2014), Vol. 15, pp. 1-17, BMC genomics, London, England, C1

journal

Molecular genetics of milk protein production

J Sharp, K Nicholas

(2014), pp. 397-432, The genetics of cattle, Wallingford, Eng., B1

chapter
2013

Identification and functional characterization of a novel monotreme - specific antibacterial protein expressed during lactation

S Bisana, S Kumar, P Rismiller, S Nicol, C Lefevre, K Nicholas, J Sharp

(2013), Vol. 8, pp. 1-12, PLoS one, San Francisco, Calif., C1

journal

The extracellular matrix locally regulates asynchronous concurrent lactation in tammar wallaby (Macropus eugenii)

S Wanyonyi, C Lefevre, J Sharp, K Nicholas

(2013), Vol. 32, pp. 342-351, Matrix biology, Amsterdam, The Netherlands, C1

journal

Lactating fur seal case study suggests miR21 may contribute to mammary gland involution evasion during off-shore lactation via regulation of PTEN

L Buscara, A Kumar, J Sharp, K Nicholas, C Lefevre

(2013), Vol. 1, pp. 5-8, Asian journal of animal research, Kerala, India, C1

journal

Molecular evolution of a novel marsupial S100 protein (S100A19) which is expressed at specific stages of mammary gland and gut development

J Kwek, A Wynne, C Lefevre, M Familari, K Nicholas, J Sharp

(2013), Vol. 69, pp. 4-16, Molecular phylogenetics and evolution, Amsterdam, The Netherlands, C1

journal

The extracellular matrix regulates MaeuCath1a gene expression

S Wanyonyi, C Lefevre, J Sharp, K Nicholas

(2013), Vol. 40, pp. 289-299, Developmental and comparative immunology, Amsterdam, The Netherlands, C1

journal
2012

WFDC2 is differentially expressed in the mammary gland of the tammar wallaby and provides immune protection to the mammary gland and the developing pouch young

A Watt, J Sharp, C Lefevre, K Nicholas

(2012), Vol. 36, pp. 584-590, Developmental and comparative immunology, Oxford, U. K., C1

journal

The tammar wallaby : a model system to examine domain-specific delivery of milk protein bioactives

K Nicholas, J Sharp, A Watt, S Wanyonyi, T Crowley, M Gillespie, C Lefevre

(2012), Vol. 23, pp. 547-556, Seminars in cell and developmental biology, London, England, C1

journal

Monotremes and marsupials : comparative models to better understand the function of milk

S Kuruppath, S Bisana, J Sharp, C Lefevre, S Kumar, K Nicholas

(2012), Vol. 37, pp. 581-588, Journal of biosciences, Karnataka, India, C1

journal
2011

Conservation of the ST6Gal I gene and its expression in the mammary gland

J Maksimovic, J Sharp, K Nicholas, B Cocks, K Savin

(2011), Vol. 21, pp. 467-481, Glycobiology, Cary, N. C., C1

journal

Tammar wallaby mammary cathelicidins are differentially expressed during lactation and exhibit antimicrobial and cell proliferative activity

S Wanyonyi, J Sharp, E Khalil, C Lefevre, K Nicholas

(2011), Vol. 160, pp. 431-439, Comparative biochemistry and physiology. Part A : molecular & integrative physiology, New York, N. Y., C1

journal
2010

Marsupial milk : identifying signals for regulating mammary function and development of the young

J Sharp, C Lefevre, J Kwek, D Topcic, L Buscara, C Pooley, R de Iongh, M Familari, K Nicholas

(2010), pp. 317-334, Marsupial genetics and genomics, Dordrecht, The Netherlands, B1

chapter

Evolution of lactation : ancient origin and extreme adaptations of the lactation system

C Lefevre, J Sharp, K Nicholas

(2010), Vol. 11, pp. 219-238, Annual review of genomics and human genetics, Palo Alto, Calif., C1

journal
2009

No evidence of expression of two classes of natural antibiotics (cathelicidins and defensins) in a sample of platypus milk

C Whittington, J Sharp, A Papenfuss, K Belov

(2009), Vol. 57, pp. 211-217, Australian journal of zoology, Melbourne, Vic., C1

journal

A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis

K Menzies, C Lefevre, J Sharp, K Macmillan, P Sheehy, K Nicholas

(2009), Vol. 20, pp. 498-503, Mammalian genome, New York, N. Y., C1

journal

Characterisation of monotreme caseins reveals lineage-specific expansion of an ancestral casein locus in mammals

C Lefevre, J Sharp, K Nicholas

(2009), Vol. 21, pp. 1015-1027, Reproduction, fertility and development, Collingwood, Vic., C1

journal

The comparative genomics of tammar wallaby and Cape fur seal lactation models to examine function of milk proteins.

J Sharp, M Digby, C Lefevre, S Mailer, E Khalil, D Topcic, A Auguste, J Kwek, A Brennan, M Familari, K Nicholas

(2009), pp. 55-79, Milk proteins : from expression to food, San Diego, Calif., B1-1

chapter

Significance, origin and function of bovine milk proteins : the biological implications of manipulation or modification

P Sheehy, P Williamson, J Sharp, K Menzies, C Lefevre, M Digby, K Nicholas, P Wynn

(2009), pp. 81-106, Milk proteins : from expression to food, San Diego, Calif., B1-1

chapter
2008

Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein as an apoptotic milk factor in mammary gland involution

J Sharp, C Lefevre, K Nicholas

(2008), Vol. 6, pp. 1-15, BMC biology, London, England, C1

journal

MammoSapiens: eResearch of the lactation program.

K Nicholas, A Kumar, Y Strahm, D Powell, T Seemann, K Daly, A Brennan, K Menzies, J Sharp, M Digby, C Lefèvre

(2008), pp. 1-13, Proceedings of eResearch Australasia 2008, Melbourne, Australia, E1

conference

Uncoupling the mechanisms that facilitate cell survival in hormone-deprived bovine mammary explants

A Brennan, J Sharp, C Lefèvre, K Nicholas

(2008), Vol. 41, pp. 103-116, Journal of molecular endocrinology, Bristol, England, C1-1

journal

Genome analysis of the platypus reveals unique signatures of evolution

J Sharp, K Nicholas, W Warren, L Hillier, J Marshall Graves, E Birney, C Ponting, F Grützner, K Belov, W Miller, L Clarke, A Chinwalla, S-P Yang, A Heger, D Locke, P Miethke, P Waters, F Veyrunes, L Fulton, B Fulton

(2008), Vol. 453, pp. 175-183, Nature, London, Eng., C1-1

journal

A population of mammary epithelial cells do not require hormones or growth factors to survive

A Brennan, J Sharp, E Khalil, M Digby, S Mailer, C Lefèvre, K Nicholas

(2008), Vol. 196, pp. 483-496, Journal of endocrinology, Bristol, Eng., C1-1

journal

Identification and transcript analysis of a novel wallaby (Macropus eugenii) basal-like breast cancer cell line

J Sharp, S Mailer, P Thomson, C Lefèvre, K Nicholas

(2008), Vol. 7, pp. 1-14, Molecular cancer, London, United Kingdom, C1-1

journal
2007

The fur seal - a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution

J Sharp, C Lefevre, A Brennan, K Nicholas

(2007), Vol. 12, pp. 47-58, Journal of mammary gland biology and neoplasia, New York, N.Y., C1-1

journal

Molecular evolution of monotreme and marsupial whey acidic protein genes

J Sharp, C Lefèvre, K Nicholas

(2007), Vol. 9, pp. 378-392, Evolution and Development, Hoboken, N.J., C1-1

journal

The tammar wallaby: a model to examine endocrine and local control of lactation

A Brennan, J Sharp, M Digby, K Nicholas

(2007), Vol. 59, pp. 146-150, IUBMB Life, Chichester, Eng., C1-1

journal
2006

Species-specific cell-matrix interactions are essential for differentiation of alveoli like structures and milk gene expression in primary mammary cells of the Cape fur seal (Arctocephalus pusillus pusillus)

J Sharp, K Cane, S Mailer, W Oosthuizen, J Arnould, K Nicholas

(2006), Vol. 25, pp. 430-442, Matrix biology, Amsterdam, The Netherlands, C1

journal
2005

The lactation cycle of the fur seal

J Sharp, K Cane, J Arnould, K Nicholas

(2005), Vol. 72, pp. 81-89, Journal of dairy research, Cambridge, England, C1

journal

Fur seal adaptations to lactation: insights into mammary gland function

J Sharp, K Cane, C Lefevre, J Arnould, K Nicholas

(2005), Vol. 72, pp. 275-308, Current topics in developmental biology, Boston, Mass., C1

journal
2004

Transfection of MDA-MB-231 human breast carcinoma cells with bone sialoprotein (BSP) stimulates migration and invasion in vitro and growth of primary and secondary tumors in nude mice

J Sharp, M Waltham, E Williams, M Henderson, E Thompson

(2004), Vol. 21, pp. 19-29, Clinical and Experimental Metastasis, Dordrecht, Netherlands, C1-1

journal
2002

Correlation between extent of osteolytic damage and metastatic burden of human breast cancer metastasis in nude mice: Real-time PCR quantitation

A Tester, A Sharp Julie, N Dhanesuan, M Waltham, E Thompson

(2002), Vol. 19, pp. 377-383, Clinical and Experimental Metastasis, Amsterdam, Netherlands, C1-1

journal

Doxycycline-inducible expression of SPARC/osteonectin/BM40 in MDA-MB-231 human breast cancer cells results in growth inhibition

N Dhanesuan, A Sharp Julie, T Blick, J Price, E Thompson

(2002), Vol. 75, pp. 73-85, Breast cancer research and treatment, New York, NY, C1-1

journal
1999

Tumor cells are the source of osteopontin and bone sialoprotein expression in human breast cancer

J Sharp, V Sung, J Slavin, E Thompson, M Henderson

(1999), Vol. 79, pp. 869-877, Laboratory investigation, London, Eng., C1-1

journal

Funded Projects at Deakin

Industry and Other Funding

Development of macroporous scaffolds for cell culture

Prof Mark Kirkland, Dr Julie Sharp, Mrs Christina Kirkland

  • 2014: $65,710

Production of neurotrophic factors by umbilical cord blood cells - Scholarship Jasmine Cleminson

Dr Cynthia Wong, Dr Julie Sharp, Prof Mark Kirkland

  • 2016: $21,485
  • 2015: $31,031

Development of bioreactor for cell expansion

Dr Cynthia Wong, Dr Julie Sharp, Prof Mark Kirkland

  • 2016: $363,724
  • 2015: $414,952

Supervisions

Principal Supervisor
2017

Sri Balaji Ponraj

Thesis entitled: Nanosecond pulsed Atmospheric Pressure Plasma for Fabrication of Hybrid Nanostructures and Decontamination of Milk

Doctor of Philosophy (Engineering), Institute for Frontier Materials

Associate Supervisor
2015

Sugeetha Ramakrishnan

Thesis entitled: The relationship between milk, mammary adipocytes and ECM in regulating murine mammary gland involution

Doctor of Philosophy (Medicine), School of Medicine

Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine

Vengama Naidu Modepalli

Thesis entitled: The Marsupial: A unique model for understanding the regulation of lung development

Doctor of Philosophy (Medicine), School of Medicine

Ashalyn Watt

Thesis entitled: Innate immunity in the breast and the role of the milk peptidome

Doctor of Philosophy (Medicine), School of Medicine

2014

Ashwantha Enjapoori

Thesis entitled: Monotreme Lactation: Characterisation of a novel protein, endocrine regulation andmiRNAs in milk

Doctor of Philosophy (Medicine), School of Medicine

Swathi Bisana

Thesis entitled: Evolution of Mammary Gland Function: A study using Monotreme Models

Doctor of Philosophy (Medicine), School of Medicine

Sanjana Kuruppath

Thesis entitled: Programmed function of the tammar mammary gland; The role of Milk Proteins in gut development.

Doctor of Philosophy (Medicine), School of Medicine