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Prof Karen Dwyer

STAFF PROFILE

Position

Affiliate Professor

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy (Med, Dentistry & Health Science), University of Melbourne, 2004
Bachelor of Medicine & Bachelor of Surgery, University of Melbourne, 1994

Contact

karen.dwyer@deakin.edu.au
+61 3 522 71421

Biography

Qualifications:

  • Diploma of Management, Swinburne University of Technology 2013
  • Melbourne Teaching Certificate, The University of Melbourne 2011
  • Doctor of Philosophy.The University of Melbourne, Australia, 2004
  • Fellow, Royal Australasian College of Physicians (Nephrology), 2001
  • Bachelor of Medicine; Bachelor of Surgery,The University of Melbourne, 1994

 

Professional activitites:

Associate Editor, Transplantation

Convenor, Transplantation Society of Australia and New Zealand Annual Scientific Meeting 2014

Convenor, Transplantation Society of Australia and New Zealand Post graduate Course 2007

The Transplantation Society, Scientific Program Committee, 2015 -

Chair, Scientific Program and Education Committee, Transplantation Society of Australia and New Zealand, 2013-2015

Transplantation Society of Australia and New Zealand, Council Member 2013-2015; Secretary 2015 -

Animal Ethics Committee, Senior Medical Staff Representative; 2008-2014

Medication Safety Committee, Medical Staff Representative: 2013-2015

Scientific committee consultant, GENESIS Research Awards Charter 2011

Actively involved in medical school education

Peer review: regular reviewer for >10 journals including Nature, Transplantation, American Journal of Transplantation, Jouranl of American Society of Nephrology, Nephrology, Journal of Immunology

Student supervision:

BSc (Hons): 2 completed; 1 current

PhD: 4 completed; 3 current

MPhil:1 completed
 

Read more on Karen's profile

Affiliations

Australian Medical Association
Australia and New Zealand Society of Nephrology (ANZSN)
Transplantation Society of Australia and New Zealand (TSANZ)
Royal Australasian College of Physicians (RACP)
American Society of Transplantation
The Transplantation Society
International Xenotransplantation Association
International Hand and Composite Allotransplantation Society

Knowledge areas

Prof Dwyer has 15 years clinical experience in the diagnosis and management of renal-related disease, including acute and chronic kidney injury, refractory hypertension and renal transplantation.

Her research interests focus on purinergic signalling, specifically the role of CD39 and adenosine signalling in health and disease.  She has developed small animal models to examine acute and chronic ischaemic induced kidney injury, and renal, liver and islet transplant related injury.

Prof Dwyer also has an interest in clinical research project specifically surrounding the diabetes arising post transplantation.

Projects

Current projects:

  1. Acute and Chornic Kidney Disease as Interconnected Syndromes: The questions to be answered in these studies are:
    1. What is the burden of chronic kidney disease following an in-patient episode of acute kidney injury utilising patient data from metropolitan and regional hospitals?
    2. What epigenetic changes are induced by an episode of ischemic-induced acute kidney injury?
    3. Do the epigenetic changes identified in the periphery correlate with changes occurring within the renal parenchyma?
    4. What is the optimal timing of timing of pharmacological A2BR activation to prevent ischaemic-induced kidney injury?
    5. What is the impact of A2BR inhibition on the development of kidney fibrosis?
    6. Is A2BR activation efficacious in the setting of cold ischaemic injury encountered in kidney transplantation?
    7. Does the novel adenosinergic compound VCP476 protect against ischaemic-induced kidney injury?
  2. Impaired glucose handling following kidney transplantation: the role of the microbiome.The questions to be answered in this study are:
    1. What changes in gut microbiota composition occur following kidney transplantation?
    2. Do the changes in gut microbiome observed in Study #1 correlate with glucose handling capacity?
    3. Are epigenetic changes induced post-transplant that increase the likelihood of developing diabetes/prediabetes? 

Publications

Filter by

2023

Recommendations for culturally safe clinical kidney care for First Nations Australians: a guideline summary.

David Tunnicliffe, Samantha Bateman, Melissa Arnold-Chamney, Karen Dwyer, Martin Howell, Azaria Gebadi, Shilpa Jesudason, Janet Kelly, Kelly Lambert, Sandawan Majoni, Dora Oliva, Kelli Owen, Odette Pearson, Elizabeth Rix, Ieyesha Roberts, Kimberly Taylor, Gary Wittert, Katherine Widders, Adela Yip, Jonathan Craig, Richard Phoon

(2023), Vol. 219, pp. 374-385, Medical Journal of Australia, London, Eng., C1

journal article
2022

Clinicians' perspectives on equity of access to dialysis and kidney transplantation for rural people in Australia: A semistructured interview study

N Scholes-Robertson, T Gutman, M Howell, J Craig, R Chalmers, K Dwyer, M Jose, I Roberts, A Tong

(2022), Vol. 12, pp. 1-11, BMJ Open, London, England, C1

journal article

Blood Plasma Metabolites in Diabetes-Associated Chronic Kidney Disease: A Focus on Lipid Profiles and Cardiovascular Risk

A Lecamwasam, T Mansell, E Ekinci, R Saffery, K Dwyer

(2022), Vol. 9, pp. 1-10, Frontiers in Nutrition, Lausanne, Switzerland, C1

journal article

Too much sugar does not just make us fat; it can also make us sick

Karen Dwyer, Breonny Robson, James Muecke

(2022), Vol. 52, pp. 1089-1092, Internal Medicine Journal, London, Eng., C1

journal article

Muscle fiber type-specific autophagy responses following an overnight fast and mixed meal ingestion in human skeletal muscle

M Morales-Scholz, S Wette, J Stokie, B Tepper, C Swinton, D Hamilton, K Dwyer, R Murphy, K Howlett, C Shaw

(2022), Vol. 323, pp. E242-E253, American Journal of Physiology - Endocrinology and Metabolism, United States, C1

journal article

Re-imaging healthcare delivery in the era of COVID-19

K Dwyer, M Axtens, G Egger, J Stevens

(2022), Vol. 52, pp. 1998-2000, Internal Medicine Journal, Australia, C1

journal article

Ectonucleoside triphosphate diphosphohydrolase-1 (CD39) impacts TGF-β1 responses: insights into cardiac fibrosis and function following myocardial infarction

T Novitskaya, S Nishat, R Covarrubias, D Wheeler, E Chepurko, O Bermeo-Blanco, Z Xu, B Baer, H He, S Moore, K Dwyer, P Cowan, Y Su, T Absi, J Schoenecker, L Bellan, W Koch, S Bansal, I Feoktistov, S Robson, E Gao, R Gumina

(2022), Vol. 323, pp. H1244-H1261, American journal of physiology. Heart and circulatory physiology, United States, C1

journal article
2021

Gut microbiome composition remains stable in individuals with diabetes-related early to late stage chronic kidney disease

A Lecamwasam, T Nelson, L Rivera, E Ekinci, R Saffery, K Dwyer

(2021), Vol. 9, pp. 1-16, Biomedicines, Switzerland, C1

journal article

Coprocytobiology: A Technical Review of Cytological Colorectal Cancer Screening in Fecal Samples

L Ryan, Y Wong, K Dwyer, D Clarke, L Kyprian, J Craig

(2021), Vol. 26, pp. 591-604, SLAS Technology, United States, C1

journal article

Blood apheresis technologies-a critical review on challenges towards efficient blood separation and treatment

C Bacal, J Maina, H Nandurkar, M Khaleel, R Guijt, Y Chang, K Dwyer, L Dumée

(2021), Vol. 2, pp. 7210-7236, Materials Advances, C1

journal article

DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease

A Lecamwasam, B Novakovic, B Meyer, E Ekinci, K Dwyer, R Saffery

(2021), Vol. 36, pp. 2027-2038, Nephrology Dialysis Transplantation, England, C1

journal article
2020

Gender Parity Remains To Be Achieved for the Range of Editorial Roles Associated with Current Australasian Medical Journals

Deborah Verran, Karen Dwyer, Ruth Hardstaff, Paul Lawton, Helen Schultz

(2020), Vol. 12, CUREUS, United States, C1

journal article

Conversion of extracellular ATP into adenosine: a master switch in renal health and disease

K Dwyer, B Kishore, S Robson

(2020), Vol. 16, pp. 509-524, Nature Reviews Nephrology, London, Eng., C1

journal article

The protective effects of human milk-derived peptides on the pancreatic islet biology

A Singh, A Kumar Enjapoori, Y Gibert, K Dwyer

(2020), Vol. 9, Biology Open, England, C1

journal article

Identification of potential biomarkers of chronic kidney disease in individuals with diabetes: Protocol for a cross-sectional observational study

A Lecamwasam, M Mohebbi, E Ekinci, K Dwyer, R Saffery

(2020), Vol. 9, JMIR Research Protocols, Canada, C1

journal article

Potential for novel biomarkers in diabetes-associated chronic kidney disease: Epigenome, metabolome, and gut microbiome

A Lecamwasam, E Ekinci, R Saffery, K Dwyer

(2020), Vol. 8, Biomedicines, Switzerland, C1

journal article
2019

In vivo endogenous proteolysisyielding beta-caseinderived bioactive beta-casomorphin peptides in human breast milk for infant nutrition

A Enjapoori, S Kukuljan, K Dwyer, J Sharp

(2019), Vol. 57, pp. 259-267, Nutrition, United States, C1

journal article

High glucose levels affect retinal patterning during zebrafish embryogenesis

A Singh, H Castillo, J Brown, J Kaslin, K Dwyer, Y Gibert

(2019), Vol. 9, Scientific Reports, England, C1

journal article

Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study

E Berglund, M Andersen Ljungdahl, D Bogdanović, D Berglund, J Wadström, J Kowalski, G Brandacher, D Kamińska, C Kaufman, S Talbot, K Azari, L Landin, C Höhnke, K Dwyer, P Cavadas, A Thione, B Clarke, S Kay, D Wilks, S Iyer, M Iglesias, Ö Özkan, Ö Özkan, J Krapf, A Weissenbacher, P Petruzzo, S Schneeberger

(2019), Vol. 103, pp. 2173-2182, Transplantation, United States, C1

journal article
2018

DNA methylation profiling of genomic DNA isolated from urine in diabetic chronic kidney disease: A pilot study

A Lecamwasam, A Sexton-Oates, J Carmody, E Ekinci, K Dwyer, R Saffery

(2018), Vol. 13, PLoS ONE, United States, C1

journal article

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

A Samudra, K Dwyer, C Selan, S Freddi, L Murray-Segal, M Nikpour, M Hickey, K Peter, S Robson, M Sashindranath, P Cowan, H Nandurkar

(2018), Vol. 88, pp. 131-138, Journal of autoimmunity, Amsterdam, The Netherlands, C1

journal article

AMP and adenosine are both ligands for adenosine 2B receptor signaling

Jessica Holien, Benjamin Seibt, Veena Roberts, Evelyn Salvaris, Michael Parker, Peter Cowan, Karen Dwyer

(2018), Vol. 28, pp. 202-206, Bioorganic and medicinal chemistry letters, Amsterdam, The Netherlands, C1-1

journal article

CD39-adenosinergic axis in renal pathophysiology and therapeutics

B Kishore, S Robson, K Dwyer

(2018), Vol. 14, pp. 109-120, Purinergic signalling, Berlin, Germany, C1

journal article

The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration

A Singh, Y Gibert, K Dwyer

(2018), Vol. 18, pp. 615-623, Pancreatology, Switzerland, C1

journal article

Dietary cows' milk protein A1 beta-casein increases the incidence of T1D in NOD mice

J Chia, J McRae, A Enjapoori, C Lefèvre, S Kukuljan, K Dwyer

(2018), Vol. 10, Nutrients, Switzerland, C1

journal article

Bone health in chronic kidney disease-mineral and bone disorder: a clinical case seminar and update

J Aleksova, K Ng, C Jung, H Zeimer, K Dwyer, F Milat, R MacIsaac

(2018), Vol. 48, pp. 1435-1446, Internal Medicine Journal, Australia, C1

journal article
2017

Mineral adaptations following kidney transplantation

S Tan, A Crosthwaite, D Langsford, V Obeysekere, F Ierino, M Roberts, P Hughes, T Hewitson, K Dwyer, N Toussaint

(2017), Vol. 30, pp. 463-473, Transplant International, Switzerland, C1

journal article

The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis after ischemia-reperfusion injury

V Roberts, D Campbell, B Lu, J Chia, P Cowan, K Dwyer

(2017), Vol. 101, pp. e194-e204, Transplantation, Philadelphia, Pa., C1

journal article

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury

M Sashindranath, K Dwyer, S Dezfouli, C Selan, S Crikis, B Lu, Y Yuan, M Hickey, K Peter, S Robson, P Cowan, H Nandurkar

(2017), Vol. 13, pp. 259-265, Purinergic signalling, Berlin, Germany, C1

journal article

A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

J Chia, J McRae, S Kukuljan, K Woodford, R Elliott, B Swinburn, K Dwyer

(2017), Vol. 7, Nutrition and Diabetes, England, C1

journal article

Evaluation of CD4⁺CD25⁺⁄⁻CD39⁺ T-cell populations in peripheral blood of patients following kidney transplantation and during acute allograft rejection

J McRae, J Chia, S Pommey, K Dwyer

(2017), Vol. 22, pp. 505-512, Nephrology, Chichester, Eng., C1

journal article

Overexpression of human CD55 and CD59 or treatment with human CD55 protects against renal ischemia-reperfusion injury in mice

A Bongoni, B Lu, E Salvaris, V Roberts, D Fang, J McRae, N Fisicaro, K Dwyer, P Cowan

(2017), Vol. 198, pp. 4837-4845, Journal of immunology, Rockville, Md., C1

journal article

Diabetes Mellitus Following Renal Transplantation: Clinical and Pharmacological Considerations for the Elderly Patient

D Langsford, A Steinberg, K Dwyer

(2017), Vol. 34, pp. 589-601, Drugs and Aging, New Zealand, C1

journal article

Gender Equity in Transplantation: A Report from the Women in Transplantation Workshop of the Transplantation Society of Australia and New Zealand

K Dwyer, C Clark, K MacDonald, M Paraskeva, N Rogers, J Ryan, A Webster, G Wong

(2017), Vol. 101, pp. 2266-2270, Transplantation, United States, C1

journal article

Systematic review of the gastrointestinal effects of A1 compared with A2 β-casein

S Brooke-Taylor, K Dwyer, K Woodford, N Kost

(2017), Vol. 8, pp. 739-748, Advances in Nutrition, United States, C1

journal article
2016

Role of the CD39/CD73 purinergic pathway in modulating arterial thrombosis in mice

R Covarrubias, E Chepurko, A Reynolds, Z Huttinger, R Huttinger, K Stanfill, D Wheeler, T Novitskaya, S Robson, K Dwyer, P Cowan, R Gumina

(2016), Vol. 36, pp. 1809-1820, Arteriosclerosis, thrombosis, and vascular biology, Philadelphia, Pa., C1

journal article

CD39 overexpression does not attenuate renal fibrosis in the unilateral ureteric obstructive model of chronic kidney disease

V Roberts, B Lu, J Chia, P Cowan, K Dwyer

(2016), Vol. 12, pp. 653-660, Purinergic Signalling, Netherlands, C1

journal article

PLA2R and membranous nephropathy: A 3 year prospective Australian study

P Hill, J McRae, K Dwyer

(2016), Vol. 21, pp. 397-403, Nephrology, Australia, C1

journal article

A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia after Renal Transplantation

D Langsford, V Obeyesekere, S Vogrin, J Teng, R MacIsaac, G Ward, F Alford, K Dwyer

(2016), Vol. 2, pp. E107-, Transplantation Direct, United States, C1

journal article

The Role of Activin A and B and the Benefit of Follistatin Treatment in Renal Ischemia-Reperfusion Injury in Mice

D Fang, B Lu, S Hayward, D de Kretser, P Cowan, K Dwyer

(2016), Vol. 2, pp. 1-9, Transplantation Direct, Philadelphia, Pennsylvania, C1

journal article
2015

The shifting paradigm of albuminuria in diabetic kidney disease

A Watts, K Dwyer, E Ekinci, G Jerums, R MacIsaac

(2015), Vol. 16, pp. 34-38, Medicine today, Neutral Bay, N.S.W., C1

journal article

Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1)

Yue Zhang, Simon Robson, Kaiya Morris, Kristina Heiney, Karen Dwyer, Bellamkonda Kishore, Carolyn Ecelbarger

(2015), Vol. 308, pp. F1398-F1408, American journal of physiology. Renal physiology, Bethesda, Md., C1

journal article

Galactose therapy reduces proteinuria in patients with recurrent focal segmental glomerulosclerosis after kidney transplantation

Kate Robson, Prudence Hill, David Langsford, Karen Dwyer, David Goodman, Robyn Langham

(2015), Vol. 20, pp. 13-16, Nephrology, Chichester, Eng., C1

journal article
2014

Adenosine receptor expression in the development of renal fibrosis following ischemic injury

V Roberts, B Lu, K Dwyer, P Cowan

(2014), Vol. 46, pp. 3257-3261, Transplantation proceedings, Amsterdam, The Netherlands, C1

journal article

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

Veena Roberts, Peter Cowan, Stephen Alexander, Simon Robson, Karen Dwyer

(2014), Vol. 86, pp. 685-692, Kidney international, Amsterdam, The Netherlands, C1

journal article

Spectrum of renal disease in diabetes

Jessie Teng, Karen Dwyer, Prue Hill, Emily See, Elif Ekinci, George Jerums, Richard MacIsaac

(2014), Vol. 19, pp. 528-536, Nephrology, London, Eng., C1

journal article

Recurrent Mycobacterium haemophilum in a renal transplant recipient

Kathryn Ducharlet, Caitlin Murphy, Sven-Jean Tan, Karen Dwyer, David Goodman, Craig Aboltins, John Daffy, Robyn Langham

(2014), Vol. 19, pp. 14-17, Nephrology, Chichester, Eng., C1

journal article

The role of ectonucleotidases CD39 and CD73 and adenosine signaling in solid organ transplantation

V Roberts, J Stagg, K Dwyer

(2014), Vol. 5, pp. 1-7, Frontiers in immunology, Lausanne, Switzerland, C1

journal article
2013

Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation

Szun Tay, Bo Lu, Fred Sierro, Volker Benseler, Claire McGuffog, G Bishop, Peter Cowan, Geoffrey McCaughan, Karen Dwyer, David Bowen, Patrick Bertolino

(2013), Vol. 19, pp. 1224-1235, Liver transplantation, London, Eng., C1

journal article

Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation

Glen Westall, Browyn Levvey, Evelyn Salvaris, Julian Gooi, Sylvana Marasco, Frank Rosenfeldt, Chris Egan, Robin McEgan Ccp, Mark Mennen, Prue Russell, Simon Robson, Mark Nottle, Karen Dwyer, Greg Snell, Peter Cowan

(2013), Vol. 32, pp. 1123-1130, Journal of heart and lung transplantation, Amsterdam, The Netherlands, C1

journal article

Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

Paul Beavis, Upulie Divisekera, Christophe Paget, Melvyn Chow, Liza John, Christel Devaud, Karen Dwyer, John Stagg, Mark Smyth, Phillip Darcy

(2013), Vol. 110, pp. 14711-14716, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1

journal article

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1

Scott Fraser, Suet-Wan Choy, Núria Pastor-Soler, Hui Li, Matthew Davies, Natasha Cook, Marina Katerelos, Peter Mount, Kurt Gleich, Jennifer McRae, Karen Dwyer, Bryce van Denderen, Kenneth Hallows, Bruce Kemp, David Power

(2013), Vol. 305, pp. F679-F690, American journal of physiology. Renal physiology, Bethesda, Md., C1

journal article

First hand transplant procedure in Australia: outcome at 2 years

Karen Dwyer, Angela Webb, Hayley Furniss, Katie Anjou, Josephine Gibbs-Dwyer, David McCombe, Damien Grinsell, Gillian Dickinson, Richard Williams, Prudence Russell, David Scott, Christopher Baker, Simon Vogrin, Robyn Langham, Helen Opdam, Wayne Morrison

(2013), Vol. 199, pp. 285-287, Medical journal of Australia, Sydney, N.S.W., C1

journal article

A case of triple pathology: Seronegative anti-glomerular basement membrane antibody-mediated glomerulonephritis and membranous nephropathy in a patient with underlying diabetic kidney disease

S Tan, K Ducharlet, K Dwyer, D Myers, R Langham, P Hill

(2013), Vol. 6, pp. 322-326, Clinical kidney journal, Oxford, Eng., C1

journal article

The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice

Joanne Chia, Jennifer McRae, Helen Thomas, Stacey Fynch, Lorraine Elkerbout, Prue Hill, Lisa Murray-Segal, Simon Robson, Jiang-Fan Chen, Anthony d'Apice, Peter Cowan, Karen Dwyer

(2013), Vol. 62, pp. 2026-2035, Diabetes, Arlington, Va., C1

journal article

The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury

Veena Roberts, Bo Lu, Siddharth Rajakumar, Peter Cowan, Karen Dwyer

(2013), Vol. 9, pp. 135-143, Purinergic signalling, Berlin, Germany, C1

journal article

Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells

Sandra Pommey, Bo Lu, Jennifer McRae, John Stagg, Prue Hill, Evelyn Salvaris, Simon Robson, Anthony d'Apice, Peter Cowan, Karen Dwyer

(2013), Vol. 57, pp. 1597-1606, Hepatology, London, Eng., C1

journal article

Overexpression of CD39 protects in a mouse model of preeclampsia

Jennifer McRae, Prudence Russell, Joanne Chia, Karen Dwyer

(2013), Vol. 18, pp. 351-355, Nephrology, London, Eng., C1

journal article
2012

Regulatory T cells participate in CD39-mediated protection from renal injury

Yuan Wang, Jennifer McRae, Simon Robson, Peter Cowan, Geoff Zhang, Min Hu, Tania Polhill, Yiping Wang, Guoping Zheng, Ya Wang, Vincent Lee, Robert Unwin, David Harris, Karen Dwyer, Stephen Alexander

(2012), Vol. 42, pp. 2441-2451, European journal of immunology, London, Eng., C1

journal article

Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1

Yue Zhang, Kaiya Morris, Shannon Sparrow, Karen Dwyer, Keiichi Enjyoji, Simon Robson, Bellamkonda Kishore

(2012), Vol. 303, pp. F420-F430, American journal of physiology. Renal physiology, Bethesda, Md., C1

journal article

Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice

Zachary Huttinger, Michael Milks, Michael Nickoli, William Aurand, Lawrence Long, Debra Wheeler, Karen Dwyer, Anthony d'Apice, Simon Robson, Peter Cowan, Richard Gumina

(2012), Vol. 181, pp. 322-333, American journal of pathology, Amsterdam, The Netherlands, C1

journal article

Transgenic swine: expression of human CD39 protects against myocardial injury

Debra Wheeler, Matthew Joseph, Shouvik Mahamud, William Aurand, Peter Mohler, Vincent Pompili, Karen Dwyer, Mark Nottle, Sharon Harrison, Anthony d'Apice, Simon Robson, Peter Cowan, Richard Gumina

(2012), Vol. 52, pp. 958-961, Journal of molecular and cellular cardiology, Amsterdam, The Netherlands, C1

journal article

The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice

Peter Mount, Kurt Gleich, Shanna Tam, Scott Fraser, Suet-Wan Choy, Karen Dwyer, Bo Lu, Bryce Van Denderen, Günter Fingerle-Rowson, Richard Bucala, Bruce Kemp, David Power

(2012), Vol. 7, pp. e29887-e29887, PLoS One, San Francisco, Calif., C1

journal article
2010

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

J Stagg, U Divisekera, N McLaughlin, J Sharkey, S Pommey, D Denoyer, K Dwyer, M Smyth

(2010), Vol. 107, pp. 1547-1552, Proceedings of the National Academy of Sciences of the United States of America, Washington, D. C., C1-1

journal article

Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype

K Dwyer, D Hanidziar, P Putheti, P Hill, S Pommey, J McRae, A Winterhalter, G Doherty, S Deaglio, M Koulmanda, W Gao, S Robson, T Strom

(2010), Vol. 10, pp. 2410-2420, American journal of transplantation, Chichester, Eng., C1-1

journal article

Antiinflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice

S Crikis, X Zhang, S Dezfouli, K Dwyer, L Murray-Segal, E Salvaris, C Selan, S Robson, H Nandurkar, P Cowan, A d'Apice

(2010), Vol. 10, pp. 242-250, American journal of transplantation, Chichester, Eng., C1-1

journal article

Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury

Siddharth Rajakumar, Bo Lu, Sandra Crikis, Simon Robson, Anthony d'Apice, Peter Cowan, Karen Dwyer

(2010), Vol. 90, pp. 1260-1264, Transplantation, Philadelphia, Pa., C1-1

journal article

Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury

S Crikis, B Lu, L Murray-Segal, C Selan, S Robson, A D'Apice, H Nandurkar, P Cowan, K Dwyer

(2010), Vol. 10, pp. 2586-2595, American journal of transplantation, Chichester, Eng., C1-1

journal article
2009

Acute Kidney Injury and Proteinuria in a Patient With Diabetes and a Submandibular Mass

P Hill, P Russell, C Sammartino, K Wiggins, K Dwyer

(2009), Vol. 54, pp. 375-380, American Journal of Kidney Diseases, Amsterdam, The Netherlands, C1-1

journal article
2008

The impact of purinergic signaling on renal ischemia-reperfusion injury

B Lu, S Rajakumar, S Robson, E Lee, S Crikis, A D'Apice, P Cowan, K Dwyer

(2008), Vol. 86, pp. 1707-1712, Transplantation, Philadelphia, Pa., C1-1

journal article
2007

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

S Deaglio, K Dwyer, W Gao, D Friedman, A Usheva, A Erat, J Chen, K Enjyoji, J Linden, M Oukka, V Kuchroo, T Strom, S Robson

(2007), Vol. 204, pp. 1257-1265, Journal of experimental medicine, Birmingham, Ala., C1-1

journal article

CD39 and control of cellular immune responses

K Dwyer, S Deaglio, W Gao, D Friedman, T Strom, S Robson

(2007), Vol. 3, pp. 171-180, Purinergic signalling, Cham, Switzerland, C1-1

journal article

Salutary roles of CD39 in transplantation

K Dwyer, S Deaglio, S Crikis, W Gao, K Enjyoji, T Strom, P Cowan, A d'Apice, S Robson

(2007), Vol. 21, pp. 54-63, Transplantation reviews, Amsterdam, The Netherlands, C1-1

journal article
2006

Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: potential as therapeutic targets

B Atkinson, K Dwyer, K Enjyoji, S Robson

(2006), Vol. 36, pp. 217-222, Blood cells, molecules, and diseases, Amsterdam, The Netherlands, C1-1

journal article

The transgenic expression of human CD39 on murine islets inhibits clotting of human blood

K Dwyer, T Mysore, S Crikis, S Robson, H Nandurkar, P Cowan, A D'Apice

(2006), Vol. 82, pp. 428-432, Transplantation, Philadelphia, Pa., C1-1

journal article

RanBPM associates with CD39 and modulates ecto-nucleotidase activity

Y Wu, X Sun, E Kaczmarek, K Dwyer, E Bianchi, A Usheva, S Robson

(2006), Vol. 396, pp. 23-30, Biochemical journal, London, Eng., C1-1

journal article
2005

Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation

S Robson, Y Wu, X Sun, C Knosalla, K Dwyer, K Enjyoji

(2005), Vol. 31, pp. 217-233, Seminars in thrombosis and hemostasis, New York, N.Y., C1-1

journal article

Oxidative stress and high-density lipoprotein function in Type I diabetes and end-stage renal disease

G Kalogerakis, A Baker, S Christov, K Rowley, K Dwyer, C Winterbourn, J Best, A Jenkins

(2005), Vol. 108, pp. 497-506, Clinical science, London, Eng., C1-1

journal article
2004

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

K Dwyer, S Robson, H Nandurkar, D Campbell, H Gock, L Murray-Segal, N Fisicaro, T Mysore, E Kaczmarek, P Cowan, A D'Apice

(2004), Vol. 113, pp. 1440-1446, Journal of clinical investigation, [New York, N.Y.], C1-1

journal article

Reversal of dialysis-dependent renal failure in light-chain deposition disease by autologous peripheral blood stem cell transplantation

F Firkin, P Hill, K Dwyer, H Gock

(2004), Vol. 44, pp. 551-555, American journal of kidney diseases, Philadelphia, Pa., C1-1

journal article
2002

Membranoproliferative glomerulonephritis in association with chronic lymphocytic leukaemia: a report of three cases

P Hill, F Firkin, K Dwyer, P Lee, B Murphy

(2002), Vol. 34, pp. 138-143, Pathology, Amsterdam, The Netherlands, C1-1

journal article

Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation

P Cowan, A Aminian, H Barlow, A Brown, K Dwyer, R Filshie, N Fisicaro, D Francis, H Gock, D Goodman, J Katsoulis, S Robson, E Salvaris, T Shinkel, A Stewart, A D'Apice

(2002), Vol. 2, pp. 520-525, American journal of transplantation, Chichester, Eng., C1-1

journal article

Severe chronic renal failure in association with oxycodone addiction: a new form of fibrillary glomerulopathy

P Hill, K Dwyer, T Kay, B Murphy

(2002), Vol. 33, pp. 783-787, Human pathology, Amsterdam, The Netherlands, C1-1

journal article

Treatment of acute renal failure caused by renal artery occlusion with renal artery angioplasty

K Dwyer, J Vrazas, R Lodge, T Humphery, S Schlicht, B Murphy, P Mossop, D Goodman

(2002), Vol. 40, pp. 189-194, American journal of kidney diseases, Amsterdam, The Netherlands, C1-1

journal article

Xenotransplantation: past achievements and future promise

K Dwyer, P Cowan, A d'Apice

(2002), Vol. 11, pp. 32-41, Heart lung and circulation, Amsterdam, The Netherlands, C1-1

journal article
2001

Membranous nephropathy and anti-neutrophil cytoplasmic antibody-associated glomerulonephritis: a report of 2 cases

K Dwyer, J Agar, P Hill, B Murphy

(2001), Vol. 56, pp. 394-397, Clinical nephrology, München-Deisenhofen, Germany, C1-1

journal article

Nocardia peritonitis and abdominal abscess complicating continuous ambulatory peritoneal dialysis

K Dwyer, J Daffy, B Murphy

(2001), Vol. 6, pp. 263-265, Nephrology, Chichester, Eng., C1-1

journal article
2000

Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy

P Hill, K Dwyer, D Power

(2000), Vol. 9, pp. 458-463, Lupus, London, Eng., C1-1

journal article

Funded Projects at Deakin

Other Public Sector Funding

A1 beta-casein derived beta-casomorphin peptides in milk and Type 1 diabetes

Prof Karen Dwyer, Dr Ashwantha Enjapoori

Department of Industry, Innovation and Science

  • 2018: $24,850
  • 2017: $25,000

National Centre for Farmer Health research

Dr Alison Kennedy, Prof Gary Rogers, Prof Karen Dwyer, Dr Jacquie Cotton, Prof Susan Brumby

Western District Health Service

  • 2024: $202,702
  • 2023: $462,259
  • 2022: $263,096
  • 2021: $223,983
  • 2020: $119,514

Research for National Centre for Farmer Health 2018-2020

Prof Karen Dwyer, Dr Alison Kennedy, Dr Jacquie Cotton, Prof Susan Brumby, Prof Gary Rogers

Western District Health Service

  • 2020: $668,421

Industry and Other Funding

Characterisation of bioactive peptides in milk

Prof Karen Dwyer, Dr Ashwantha Enjapoori

A2 Infant Nutrition Australia Pty Ltd

  • 2017: $13,000
  • 2016: $60,000

A1 beta-casein derived beta-casomorphin peptides in milk and Type 1 diabetes

Prof Karen Dwyer, Dr Ashwantha Enjapoori

A2 Infant Nutrition Australia Pty Ltd

  • 2017: $37,527
  • 2016: $12,509

The influence of A1 beta-casein on Type 1 Diabetes susceptibility in NOD mice

Prof Karen Dwyer, Dr Ashwantha Enjapoori

A2 Infant Nutrition Australia Pty Ltd

  • 2018: $75,000
  • 2017: $175,000

Metabolic Health Programme

Prof Karen Dwyer

Epworth Foundation

  • 2023: $5,000
  • 2022: $5,000

Implementation of SMA program addressing hypertension in one GP practice.

Prof Karen Dwyer, Dr Michael Axtens

Servier Laboratories (Aust) Pty Ltd

  • 2023: $21,400

Supervisions

Principal Supervisor
2023

Christine Bacal

Thesis entitled: Developing Haemodialysis Membrane Materials for Acetaminophen Capture

Doctor of Philosophy (Medicine), School of Medicine

2021

Ashani Lecamwasam

Thesis entitled: The potential for novel biomarkers in diabetic chronic kidney disease

Doctor of Philosophy (Medicine), School of Medicine

2019

Amitoj Singh

Thesis entitled: Modelling of the foetal conditions leading to organ development disorders using zebrafish.

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2021

Sarah Catherine Burgess

Thesis entitled: Preparing pre-clinical medical students for learning in the clinical environment

Master of Philosophy (Medicine), School of Medicine

2020

Thomas Quinn

Thesis entitled: Understanding Sequencing Data as Compositions

Doctor of Philosophy (Medicine), School of Medicine