Prof Karen Dwyer

STAFF PROFILE

Position

Deputy Head Of School

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Contact

karen.dwyer@deakin.edu.au
+61 3 522 71421

Biography

Qualifications:

  • Diploma of Management, Swinburne University of Technology 2013
  • Melbourne Teaching Certificate, The University of Melbourne 2011
  • Doctor of Philosophy.The University of Melbourne, Australia, 2004
  • Fellow, Royal Australasian College of Physicians (Nephrology), 2001
  • Bachelor of Medicine; Bachelor of Surgery,The University of Melbourne, 1994

 

Professional activitites:

Associate Editor, Transplantation

Convenor, Transplantation Society of Australia and New Zealand Annual Scientific Meeting 2014

Convenor, Transplantation Society of Australia and New Zealand Post graduate Course 2007

The Transplantation Society, Scientific Program Committee, 2015 -

Chair, Scientific Program and Education Committee, Transplantation Society of Australia and New Zealand, 2013-2015

Transplantation Society of Australia and New Zealand, Council Member 2013-2015; Secretary 2015 -

Animal Ethics Committee, Senior Medical Staff Representative; 2008-2014

Medication Safety Committee, Medical Staff Representative: 2013-2015

Scientific committee consultant, GENESIS Research Awards Charter 2011

Actively involved in medical school education

Peer review: regular reviewer for >10 journals including Nature, Transplantation, American Journal of Transplantation, Jouranl of American Society of Nephrology, Nephrology, Journal of Immunology

Student supervision:

BSc (Hons): 2 completed; 1 current

PhD: 4 completed; 3 current

MPhil:1 completed
 

Read more on Karen's profile

Affiliations

Australian Medical Association
Australia and New Zealand Society of Nephrology (ANZSN)
Transplantation Society of Australia and New Zealand (TSANZ)
Royal Australasian College of Physicians (RACP)
American Society of Transplantation
The Transplantation Society
International Xenotransplantation Association
International Hand and Composite Allotransplantation Society

Knowledge areas

Prof Dwyer has 15 years clinical experience in the diagnosis and management of renal-related disease, including acute and chronic kidney injury, refractory hypertension and renal transplantation.

Her research interests focus on purinergic signalling, specifically the role of CD39 and adenosine signalling in health and disease.  She has developed small animal models to examine acute and chronic ischaemic induced kidney injury, and renal, liver and islet transplant related injury.

Prof Dwyer also has an interest in clinical research project specifically surrounding the diabetes arising post transplantation.

Projects

Current projects:

  1. Acute and Chornic Kidney Disease as Interconnected Syndromes: The questions to be answered in these studies are:
    1. What is the burden of chronic kidney disease following an in-patient episode of acute kidney injury utilising patient data from metropolitan and regional hospitals?
    2. What epigenetic changes are induced by an episode of ischemic-induced acute kidney injury?
    3. Do the epigenetic changes identified in the periphery correlate with changes occurring within the renal parenchyma?
    4. What is the optimal timing of timing of pharmacological A2BR activation to prevent ischaemic-induced kidney injury?
    5. What is the impact of A2BR inhibition on the development of kidney fibrosis?
    6. Is A2BR activation efficacious in the setting of cold ischaemic injury encountered in kidney transplantation?
    7. Does the novel adenosinergic compound VCP476 protect against ischaemic-induced kidney injury?
  2. Impaired glucose handling following kidney transplantation: the role of the microbiome.The questions to be answered in this study are:
    1. What changes in gut microbiota composition occur following kidney transplantation?
    2. Do the changes in gut microbiome observed in Study #1 correlate with glucose handling capacity?
    3. Are epigenetic changes induced post-transplant that increase the likelihood of developing diabetes/prediabetes? 

Publications

Filter by

2018

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

A Samudra, K Dwyer, C Selan, S Freddi, L Murray-Segal, M Nikpour, M Hickey, K Peter, S Robson, M Sashindranath, P Cowan, H Nandurkar

(2018), Vol. 88, pp. 131-138, Journal of autoimmunity, Amsterdam, The Netherlands, C1

journal

AMP and adenosine are both ligands for adenosine 2B receptor signaling

Jessica Holien, Benjamin Seibt, Veena Roberts, Evelyn Salvaris, Michael Parker, Peter Cowan, Karen Dwyer

(2018), Vol. 28, pp. 202-206, Bioorganic and medicinal chemistry letters, Amsterdam, The Netherlands, C1-1

journal

CD39-adenosinergic axis in renal pathophysiology and therapeutics

B Kishore, S Robson, K Dwyer

(2018), Vol. 14, pp. 109-120, Purinergic signalling, Berlin, Germany, C1

journal

The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration

Amitoj Singh, Yann Gibert, Karen Dwyer

(2018), Vol. 18, pp. 615-623, Pancreatology, Amsterdam, The Netherlands, C1

journal
2017

Mineral adaptations following kidney transplantation

S-J Tan, A Crosthwaite, D Langsford, V Obeysekere, F Ierino, M Roberts, P Hughes, T Hewitson, K Dwyer, N Toussaint

(2017), Vol. 30, pp. 463-473, Transplant international, Chichester, Eng., C1

journal

The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis after ischemia-reperfusion injury

V Roberts, D Campbell, B Lu, J Chia, P Cowan, K Dwyer

(2017), Vol. 101, pp. e194-e204, Transplantation, Philadelphia, Pa., C1

journal

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury

M Sashindranath, K Dwyer, S Dezfouli, C Selan, S Crikis, B Lu, Y Yuan, M Hickey, K Peter, S Robson, P Cowan, H Nandurkar

(2017), Vol. 13, pp. 259-265, Purinergic signalling, Berlin, Germany, C1

journal

A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

J Chia, J McRae, S Kukuljan, K Woodford, R Elliott, B Swinburn, K Dwyer

(2017), Vol. 7, pp. 1-7, Nutrition & diabetes, London, Eng., C1

journal

Evaluation of CD4?CD25???CD39? T-cell populations in peripheral blood of patients following kidney transplantation and during acute allograft rejection

J McRae, J Chia, S Pommey, K Dwyer

(2017), Vol. 22, pp. 505-512, Nephrology, Chichester, Eng., C1

journal

Overexpression of human CD55 and CD59 or treatment with human CD55 protects against renal ischemia-reperfusion injury in mice

A Bongoni, B Lu, E Salvaris, V Roberts, D Fang, J McRae, N Fisicaro, K Dwyer, P Cowan

(2017), Vol. 198, pp. 4837-4845, Journal of immunology, Rockville, Md., C1

journal

Diabetes mellitus following renal transplantation: clinical and pharmacological considerations for the elderly patient

D Langsford, A Steinberg, K Dwyer

(2017), Vol. 34, pp. 589-601, Drugs and aging, Berlin, Germany, C1

journal

Gender equity in transplantation: a report from the women in transplantation workshop of the Transplantation Society of Australia and New Zealand

K Dwyer, C Clark, K MacDonald, M Paraskeva, N Rogers, J Ryan, A Webster, G Wong

(2017), Vol. 101, pp. 2266-2270, Transplantation, Baltimore, Md., C1

journal

Systematic review of the gastrointestinal effects of A1 compared with A2 ?-Casein

S Brooke-Taylor, K Dwyer, K Woodford, N Kost

(2017), Vol. 8, pp. 739-748, Advances in nutrition, Oxford, Eng., C1

journal
2016

Role of the CD39/CD73 purinergic pathway in modulating arterial thrombosis in mice

R Covarrubias, E Chepurko, A Reynolds, Z Huttinger, R Huttinger, K Stanfill, D Wheeler, T Novitskaya, S Robson, K Dwyer, P Cowan, R Gumina

(2016), Vol. 36, pp. 1809-1820, Arteriosclerosis, thrombosis, and vascular biology, Philadelphia, Pa., C1

journal

CD39 overexpression does not attenuate renal fibrosis in the unilateral ureteric obstructive model of chronic kidney disease

V Roberts, B Lu, J Chia, P Cowan, K Dwyer

(2016), Vol. 12, pp. 653-660, Purinergic signalling, Dordrecht, The Netherlands, C1

journal

PLA2R and membranous nephropathy: A 3?year prospective Australian study

Prue Hill, Jennifer McRae, Karen Dwyer

(2016), Vol. 21, pp. 397-403, Nephrology, London, Eng., C1

journal
2015

Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1)

Yue Zhang, Simon Robson, Kaiya Morris, Kristina Heiney, Karen Dwyer, Bellamkonda Kishore, Carolyn Ecelbarger

(2015), Vol. 308, pp. F1398-F1408, American journal of physiology. Renal physiology, Bethesda, Md., C1

journal

Galactose therapy reduces proteinuria in patients with recurrent focal segmental glomerulosclerosis after kidney transplantation

Kate Robson, Prudence Hill, David Langsford, Karen Dwyer, David Goodman, Robyn Langham

(2015), Vol. 20, pp. 13-16, Nephrology, Chichester, Eng., C1

journal
2014

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

Veena Roberts, Peter Cowan, Stephen Alexander, Simon Robson, Karen Dwyer

(2014), Vol. 86, pp. 685-692, Kidney international, Amsterdam, The Netherlands, C1

journal

Recurrent Mycobacterium haemophilum in a renal transplant recipient

Kathryn Ducharlet, Caitlin Murphy, Sven-Jean Tan, Karen Dwyer, David Goodman, Craig Aboltins, John Daffy, Robyn Langham

(2014), Vol. 19, pp. 14-17, Nephrology, Chichester, Eng., C1

journal
2013

Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation

Szun Tay, Bo Lu, Fred Sierro, Volker Benseler, Claire McGuffog, G Bishop, Peter Cowan, Geoffrey McCaughan, Karen Dwyer, David Bowen, Patrick Bertolino

(2013), Vol. 19, pp. 1224-1235, Liver transplantation, London, Eng., C1

journal

Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation

Glen Westall, Browyn Levvey, Evelyn Salvaris, Julian Gooi, Sylvana Marasco, Frank Rosenfeldt, Chris Egan, Robin McEgan Ccp, Mark Mennen, Prue Russell, Simon Robson, Mark Nottle, Karen Dwyer, Greg Snell, Peter Cowan

(2013), Vol. 32, pp. 1123-1130, Journal of heart and lung transplantation, Amsterdam, The Netherlands, C1

journal

Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

Paul Beavis, Upulie Divisekera, Christophe Paget, Melvyn Chow, Liza John, Christel Devaud, Karen Dwyer, John Stagg, Mark Smyth, Phillip Darcy

(2013), Vol. 110, pp. 14711-14716, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1

journal

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1

Scott Fraser, Suet-Wan Choy, Núria Pastor-Soler, Hui Li, Matthew Davies, Natasha Cook, Marina Katerelos, Peter Mount, Kurt Gleich, Jennifer McRae, Karen Dwyer, Bryce van Denderen, Kenneth Hallows, Bruce Kemp, David Power

(2013), Vol. 305, pp. F679-F690, American journal of physiology. Renal physiology, Bethesda, Md., C1

journal

First hand transplant procedure in Australia: outcome at 2 years

Karen Dwyer, Angela Webb, Hayley Furniss, Katie Anjou, Josephine Gibbs-Dwyer, David McCombe, Damien Grinsell, Gillian Dickinson, Richard Williams, Prudence Russell, David Scott, Christopher Baker, Simon Vogrin, Robyn Langham, Helen Opdam, Wayne Morrison

(2013), Vol. 199, pp. 285-287, Medical journal of Australia, Sydney, N.S.W., C1

journal

The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice

Joanne Chia, Jennifer McRae, Helen Thomas, Stacey Fynch, Lorraine Elkerbout, Prue Hill, Lisa Murray-Segal, Simon Robson, Jiang-Fan Chen, Anthony d'Apice, Peter Cowan, Karen Dwyer

(2013), Vol. 62, pp. 2026-2035, Diabetes, Arlington, Va., C1

journal

The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury

Veena Roberts, Bo Lu, Siddharth Rajakumar, Peter Cowan, Karen Dwyer

(2013), Vol. 9, pp. 135-143, Purinergic signalling, Berlin, Germany, C1

journal

Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells

Sandra Pommey, Bo Lu, Jennifer McRae, John Stagg, Prue Hill, Evelyn Salvaris, Simon Robson, Anthony d'Apice, Peter Cowan, Karen Dwyer

(2013), Vol. 57, pp. 1597-1606, Hepatology, London, Eng., C1

journal

Overexpression of CD39 protects in a mouse model of preeclampsia

Jennifer McRae, Prudence Russell, Joanne Chia, Karen Dwyer

(2013), Vol. 18, pp. 351-355, Nephrology, London, Eng., C1

journal
2012

Regulatory T cells participate in CD39-mediated protection from renal injury

Yuan Wang, Jennifer McRae, Simon Robson, Peter Cowan, Geoff Zhang, Min Hu, Tania Polhill, Yiping Wang, Guoping Zheng, Ya Wang, Vincent Lee, Robert Unwin, David Harris, Karen Dwyer, Stephen Alexander

(2012), Vol. 42, pp. 2441-2451, European journal of immunology, London, Eng., C1

journal

Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1

Yue Zhang, Kaiya Morris, Shannon Sparrow, Karen Dwyer, Keiichi Enjyoji, Simon Robson, Bellamkonda Kishore

(2012), Vol. 303, pp. F420-F430, American journal of physiology. Renal physiology, Bethesda, Md., C1

journal

Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice

Zachary Huttinger, Michael Milks, Michael Nickoli, William Aurand, Lawrence Long, Debra Wheeler, Karen Dwyer, Anthony d'Apice, Simon Robson, Peter Cowan, Richard Gumina

(2012), Vol. 181, pp. 322-333, American journal of pathology, Amsterdam, The Netherlands, C1

journal

Transgenic swine: expression of human CD39 protects against myocardial injury

Debra Wheeler, Matthew Joseph, Shouvik Mahamud, William Aurand, Peter Mohler, Vincent Pompili, Karen Dwyer, Mark Nottle, Sharon Harrison, Anthony d'Apice, Simon Robson, Peter Cowan, Richard Gumina

(2012), Vol. 52, pp. 958-961, Journal of molecular and cellular cardiology, Amsterdam, The Netherlands, C1

journal
2010

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

J Stagg, U Divisekera, N McLaughlin, J Sharkey, S Pommey, D Denoyer, K Dwyer, M Smyth

(2010), Vol. 107, pp. 1547-1552, Proceedings of the National Academy of Sciences of the United States of America, Washington, D. C., C1-1

journal

Funded Projects at Deakin

Other Public Sector Funding

A1 beta-casein derived beta-casomorphin peptides in milk and Type 1 diabetes

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2018: $24,850
  • 2017: $25,000

Industry and Other Funding

Characterisation of bioactive peptides in milk

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2017: $26,000
  • 2016: $120,000

A1 beta-casein derived beta-casomorphin peptides in milk and Type 1 diabetes

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2017: $37,527
  • 2016: $12,509

The influence of A1 beta-casein on Type 1 Diabetes susceptibility in NOD mice

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2018: $75,000
  • 2017: $175,000

Supervisions

No completed student supervisions to report