Prof Karen Dwyer

STAFF PROFILE

Position

Deputy Head Of School

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Contact

karen.dwyer@deakin.edu.au
+61 3 522 71421

Biography

Qualifications:

  • Diploma of Management, Swinburne University of Technology 2013
  • Melbourne Teaching Certificate, The University of Melbourne 2011
  • Doctor of Philosophy.The University of Melbourne, Australia, 2004
  • Fellow, Royal Australasian College of Physicians (Nephrology), 2001
  • Bachelor of Medicine; Bachelor of Surgery,The University of Melbourne, 1994

 

Professional activitites:

Associate Editor, Transplantation

Convenor, Transplantation Society of Australia and New Zealand Annual Scientific Meeting 2014

Convenor, Transplantation Society of Australia and New Zealand Post graduate Course 2007

The Transplantation Society, Scientific Program Committee, 2015 -

Chair, Scientific Program and Education Committee, Transplantation Society of Australia and New Zealand, 2013-2015

Transplantation Society of Australia and New Zealand, Council Member 2013-2015; Secretary 2015 -

Animal Ethics Committee, Senior Medical Staff Representative; 2008-2014

Medication Safety Committee, Medical Staff Representative: 2013-2015

Scientific committee consultant, GENESIS Research Awards Charter 2011

Actively involved in medical school education

Peer review: regular reviewer for >10 journals including Nature, Transplantation, American Journal of Transplantation, Jouranl of American Society of Nephrology, Nephrology, Journal of Immunology

Student supervision:

BSc (Hons): 2 completed; 1 current

PhD: 4 completed; 3 current

MPhil:1 completed
 

Read more on Karen's profile

Affiliations

Australian Medical Association
Australia and New Zealand Society of Nephrology (ANZSN)
Transplantation Society of Australia and New Zealand (TSANZ)
Royal Australasian College of Physicians (RACP)
American Society of Transplantation
The Transplantation Society
International Xenotransplantation Association
International Hand and Composite Allotransplantation Society

Knowledge areas

Prof Dwyer has 15 years clinical experience in the diagnosis and management of renal-related disease, including acute and chronic kidney injury, refractory hypertension and renal transplantation.

Her research interests focus on purinergic signalling, specifically the role of CD39 and adenosine signalling in health and disease.  She has developed small animal models to examine acute and chronic ischaemic induced kidney injury, and renal, liver and islet transplant related injury.

Prof Dwyer also has an interest in clinical research project specifically surrounding the diabetes arising post transplantation.

Projects

Current projects:

  1. Acute and Chornic Kidney Disease as Interconnected Syndromes: The questions to be answered in these studies are:
    1. What is the burden of chronic kidney disease following an in-patient episode of acute kidney injury utilising patient data from metropolitan and regional hospitals?
    2. What epigenetic changes are induced by an episode of ischemic-induced acute kidney injury?
    3. Do the epigenetic changes identified in the periphery correlate with changes occurring within the renal parenchyma?
    4. What is the optimal timing of timing of pharmacological A2BR activation to prevent ischaemic-induced kidney injury?
    5. What is the impact of A2BR inhibition on the development of kidney fibrosis?
    6. Is A2BR activation efficacious in the setting of cold ischaemic injury encountered in kidney transplantation?
    7. Does the novel adenosinergic compound VCP476 protect against ischaemic-induced kidney injury?
  2. Impaired glucose handling following kidney transplantation: the role of the microbiome.The questions to be answered in this study are:
    1. What changes in gut microbiota composition occur following kidney transplantation?
    2. Do the changes in gut microbiome observed in Study #1 correlate with glucose handling capacity?
    3. Are epigenetic changes induced post-transplant that increase the likelihood of developing diabetes/prediabetes? 

Publications

Filter by

2017

Mineral adaptations following kidney transplantation

S-J Tan, A Crosthwaite, D Langsford, V Obeysekere, F Ierino, M Roberts, P Hughes, T Hewitson, K Dwyer, N Toussaint

(2017), Vol. 30, pp. 463-473, Transplant international, Chichester, Eng., C1

journal

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury

M Sashindranath, K Dwyer, S Dezfouli, C Selan, S Crikis, B Lu, Y Yuan, M Hickey, K Peter, S Robson, P Cowan, H Nandurkar

(2017), Vol. 13, pp. 259-265, Purinergic signalling, Berlin, Germany, C1

journal

A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

J Chia, J McRae, S Kukuljan, K Woodford, R Elliott, B Swinburn, K Dwyer

(2017), Vol. 7, pp. 1-7, Nutrition & diabetes, London, Eng., C1

journal

Evaluation of CD4?CD25???CD39? T-cell populations in peripheral blood of patients following kidney transplantation and during acute allograft rejection

J McRae, J Chia, S Pommey, K Dwyer

(2017), Vol. 22, pp. 505-512, Nephrology, Chichester, Eng., C1

journal

Overexpression of human CD55 and CD59 or treatment with human CD55 protects against renal ischemia-reperfusion injury in mice

A Bongoni, B Lu, E Salvaris, V Roberts, D Fang, J McRae, N Fisicaro, K Dwyer, P Cowan

(2017), Vol. 198, pp. 4837-4845, Journal of immunology, Rockville, Md., C1

journal

Diabetes Mellitus Following Renal Transplantation: Clinical and Pharmacological Considerations for the Elderly Patient.

David Langsford, Adam Steinberg, Karen Dwyer

(2017), Vol. 34, pp. 589-601, Drugs Aging, New Zealand, C1

journal

Gender Equity in Transplantation: A Report from the Women in Transplantation Workshop of The Transplantation Society of Australia and New Zealand.

Karen Dwyer, Carolyn Clark, Kelli MacDonald, Miranda Paraskeva, Natasha Rogers, Jessica Ryan, Angela Webster, Germaine Wong

(2017), Vol. 101, pp. 2266-2270, Transplantation, United States, C1

journal
2016

Role of the CD39/CD73 purinergic pathway in modulating arterial thrombosis in mice

R Covarrubias, E Chepurko, A Reynolds, Z Huttinger, R Huttinger, K Stanfill, D Wheeler, T Novitskaya, S Robson, K Dwyer, P Cowan, R Gumina

(2016), Vol. 36, pp. 1809-1820, Arteriosclerosis, thrombosis, and vascular biology, Philadelphia, Pa., C1

journal

CD39 overexpression does not attenuate renal fibrosis in the unilateral ureteric obstructive model of chronic kidney disease

V Roberts, B Lu, J Chia, P Cowan, K Dwyer

(2016), Vol. 12, pp. 653-660, Purinergic signalling, Dordrecht, The Netherlands, C1

journal
2010

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

J Stagg, U Divisekera, N McLaughlin, J Sharkey, S Pommey, D Denoyer, K Dwyer, M Smyth

(2010), Vol. 107, pp. 1547-1552, Proceedings of the National Academy of Sciences of the United States of America, Washington, D. C., C1-1

journal

Funded Projects at Deakin

Industry and Other Funding

Characterisation of bioactive peptides in milk

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2017: $26,000
  • 2016: $120,000

A1 beta-casein derived beta-casomorphin peptides in milk and Type 1 diabetes

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2017: $37,527
  • 2016: $12,509

The influence of A1 beta-casein on Type 1 Diabetes susceptibility in NOD mice

Prof Karen Dwyer, Dr Ashwantha Enjapoori

  • 2017: $125,000

Supervisions

No completed student supervisions to report