Prof Ken Walder

STAFF PROFILE

Position

Chair In Metabolic Diseases

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy, Deakin University, 1998

Contact

ken.walder@deakin.edu.au
+61 3 522 72883

Biography

Professor Walder is the Chair of Metabolic Diseases in the School of Medicine and the Molecular and Medical Research SRC. His research focuses on obesity and type 2 diabetes, and mental health disorders, and in particular the discovery of novel treatments for these diseases. After spending 2 years at the National Institutes of Health in Phoenix, Arizona, Professor Walder returned to Deakin University where he has played a key role in the evolution of the Metabolic Research Unit. He has authored more than 75 academic publications and is named as an inventor on more than 40 patent applications. Professor Walder has worked closely with a number of industry partners, and is focused on conducting applied research with tangible outcomes that benefit Australia. In 2014, a compound discovered in Professor Walder’s laboratory successfully completed a Phase 2 clinical trial for the treatment of type 2 diabetes.

Read more on Ken's profile

Career highlights

A new drug for diabetes discovered in Prof Walder's laboratory successfully completed a phase 2 clinical trial, where it caused a significant reduction in plasma HbA1c levels (Simpson et al. Diabetes Care, 2014).

Research interests

Professor Walders research is primarily focused on the discovery and validation of novel drug treatments for complex diseases. This research utilises state of the art equipment and technologies, in combination with unique model systems and sample collections, to screen for small molecules that can be used to treat complex diseases. The novel drug candidates are tested in in vitro and in vivo model systems to establish their potential for development as therapeutics.

Affiliations

European Association for the Study of Diabetes

American Diabetes Association

Australian Diabetes Society

International Association for the Study of Obesity

North American Association for the Study of Obesity

Australian Society for the Study of Obesity

Teaching interests

5 PhD students

Medical Innovations component of HBS400 (Honours)

Units taught

HBS400 (Medical Innovations)

Knowledge areas

Metabolic diseases (obesity, type 2 diabetes, non-alcoholic fatty liver disease).

Mental health (depression, bipolar disorder, schizophrenia).

Genetics.

Drug discovery.

Conferences

Invited presentations at national and international conferences including:

Australian Diabetes Society Annual Scientific Meeting, Sydney, August 2013. Invited seminar presentation: “VVP808 and fatty liver disease”.


Baker-IDI Research Institute Seminar Series, Melbourne, October 2011. Invited seminar presentation: “Use of GES technology to discover a new insulin sensitising agent”.


Frontiers in Obesity Research, Melbourne, September 2011. Invited seminar presentation: “VVP808: A novel insulin sensitising agent”.


University of Melbourne Department of Medicine Seminar Series, Melbourne, May 2010. Invited seminar presentation: “VVP808: A novel insulin sensitising agent”.


Monash University Obesity Diabetes Institute, Melbourne, June 2010. Invited seminar presentation: “Mechanism of action of VVP808”.


MSD Diabetes Meeting, Sydney, October 11-12, 2008. Symposium presentation: “Overview of mitochondrial dysfunction in diabetes”.


GTCbio 3rd Metabolic Diseases World Summit, San Diego, USA, November 1-2, 2007. Symposium presentation: “Use of gene expression signatures to discover novel diabetes therapeutics”.


ASSO 15th Annual Scientific Meeting, Canberra, Australia, August 31-September 2, 2007. Symposium presentation: “The adipocyte as an endocrine organ”.


2nd International Congress on Prediabetes and the Metabolic Syndrome, Barcelona, Spain, April 25-28, 2007. Symposium presentation: “The mitochondrial protease PARL and type 2 diabetes”.


2nd Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group, Kyoto, Japan, August 26-7, 2006. Symposium presentation: “CXS741, A Novel Secreted Protein Involved in the Pathogenesis of Obesity and Type 2 Diabetes”.


1st Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group, Kobe, Japan, August 20-1, 2005. Symposium presentation: “Genetic variation in PSARL is associated with plasma insulin concentration”.

Awards

1998 Fogarty Fellowship (NIH)

2006 Smart Geelong Network Biotechnology Researcher of the Year

Projects

Professor Walder serves as a reviewer for the following journals:

Diabetes

Diabetologia

International Journal of Obesity

Molecular and General Genetics

Kidney International

Pancreas



Professor Walder regularly reviews research applications for national and international funding bodies, including NHMRC and ARC.

Publications

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2016

The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases

Gerwyn Morris, Prof Michael Berk, Piotr Galecki, Prof Ken Walder, Prof Michael Maes

(2016), Vol. 53, pp. 1195-1219, Molecular neurobiology, Berlin, Germany, C1

journal

Citalopram and sertraline exposure compromises embryonic bone development

Mr Daniel Fraher, Dr Jason Hodge, Dr Fiona Collier, Ms Josephine Mcmillan, Richard L. Kennedy, Ms Megan Ellis, Geoff C. Nicholson, Prof Ken Walder, Dr Seetal Dodd, Prof Michael Berk, Prof Julie Pasco, A/Prof Lana Williams, Dr Yann Gibert

(2016), Vol. 21, pp. 656-664, Molecular psychiatry, London, Eng., C1

journal

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

Melinda T Coughlan, Gavin C. Higgins, Tuong-Vi Nguyen, Sally Penfold, Vicki Thallas Bonke, Sih Min Tan, Georg Ramm, Nicole J. Van Bergen, Darren C. Henstridge, Karly C. Sourris, Dr Brooke Elyse Harcourt, Ian A. Trounce, Portia M. Robb, Adrienne Laskowski, A/Prof Sean Mcgee, Dr Amanda Genders, Prof Ken Walder, Brian G. Drew, Dr Paul Gregorevic, Hongwei Qian, Merlin C. Thomas, George Jerums, Richard J. Macisaac, Alison Skene, David A Power, Elif I. Ekinci, Xiaonan W. Wijeyeratne, Linda A. Gallo, Michal Herman-Edelstein, A/Prof Michael Thomas Ryan, Mark E. Cooper, David R. Thorburn, Josephine M. Forbes

(2016), Vol. 65, pp. 1085-1098, Diabetes, Alexandria, Va., C1

journal

The role of the microbial metabolites including tryptophan catabolites and short chain fatty acids in the pathophysiology of immune-inflammatory and neuroimmunue disease.

Gerwyn Morris, Prof Michael Berk, Andre F Carvalho, Javier Caso, Yolanda sanz, Prof Ken Walder, Prof Michael Maes

(2016), pp. 1-20, Molecular neurobiology, Berlin, Germany, C1

journal

The deleterious effects of oxidative and nitrosative stress on palmitoylation, membrane lipid rafts and lipid-based cellular signalling : new drug targets in neuroimmune disorders

Gerwyn Morris, Prof Ken Walder, Basant Puri, Prof Michael Berk, Prof Michael Maes

(2016), Vol. 53, pp. 4638-4658, Molecular neurobiology, New York, N.Y., C1

journal

Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents

Mr Rajneesh Chaudhary, Dr Kislay Roy, Dr Rupinder Kanwar, Prof Ken Walder, Prof Jagat Kanwar

(2016), Vol. 14, pp. 1-17, Journal of nanobiotechnology, London, Eng., C1

journal

Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

Yesul Kim, A/Prof Sean Mcgee, Juliane Czeczor, Mr Adam Walker, Mr Rajas Kale, Prof Abbas Kouzani, Prof Ken Walder, Prof Michael Berk, Dr Susannah Tye

(2016), Vol. 6, pp. 1-7, Translational psychiatry, London, Eng., C1

journal

Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation

Ms Vidhi Gaur, Mr Timothy Connor, Mr Andrew Sanigorski, Miss Sheree Martin, A/Prof Clinton Bruce, Darren C. Henstridge, Mr Simon Bond, Mr Kevin McEwen, Ms Lyndal Bayles, Dr Trent Ashton, Miss Cassandra Fleming, Min Wu, Lisa Pike Winer, Denise Chen, Gregg Hudson, John Schwabe, Keith Baar, Prof Mark Febbraio, Dr Paul Gregorevic, A/Prof Fred Pfeffer, Prof Ken Walder, Prof Mark Hargreaves, A/Prof Sean Mcgee

(2016), Vol. 16, pp. 2802-2810, Cell reports, New York, N.Y., C1

journal

Functional analysis of a Type-I ribosome inactivating protein balsamin from Momordica balsamina with anti-microbial and DNase activity

Ms Parminder Kaur Ajji, Prof Ken Walder, Dr Munish Puri

(2016), Vol. 71, pp. 265-271, Plant foods for human nutrition, New York, N.Y., C1

journal

Pathways of acetyl-CoA metabolism involved in the reversal of palmitate-induced glucose production by metformin and salicylate

Bradley Hayward, Dr Juan Carlos Molero-Navajas, Dr Kelly Windmill, Mr Andrew Sanigorski, J Weir, Miss Natasha Lee McRae, Dr Kathryn Aston-Mourney, B Osborne, B Liao, Prof Ken Walder, K Meikle, Dr Nicky Konstantopoulos, Carsten Schmitz-Peiffer

(2016), Vol. 124, pp. 602-612, Experimental and clinical endocrinology and diabetes, Munich, Germany, C1

journal
2015

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.

Lennart Zabeau, Cathy Jensen, Sylvie Seeuws, Koen Venken, Annick Verhee, Dominiek Catteeuw, Geert van Loo, Hui Chen, Prof Ken Walder, Jacob Hollis, Simon Foote, Margaret J Morris, Jose Van der Heyden, Frank Peelman, Brian Oldfield, Justin Rubio, Dirk Elewaut, Jan Tavernier

(2015), Vol. 72, pp. 629-644, Cellular and Molecular Life Sciences, Switzerland, C1

journal

CXCR4 Antagonism attenuates the development of diabetic cardiac fibrosis

Po-Yin Chu, Prof Ken Walder, Duncan Horlock, Dr David Williams, Erin Nelson, Melissa Byrne, Karin Jandeleit-Dahm, Prof Paul Zimmet, David Kaye

(2015), Vol. 10, pp. 1-13, PLoS One, San Francisco, CA, C1

journal

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Gerwyn Morris, Prof Michael Berk, Prof Ken Walder, Prof Michael Maes

(2015), Vol. 13, pp. 1-23, BMC Medicine, London, Eng., C1

journal

Evolution of optogenetic microdevices

Mr Rajas Kale, Prof Abbas Kouzani, Prof Ken Walder, Prof Michael Berk, Dr Susannah Tye

(2015), Vol. 2, pp. 1-11, Neurophotonics, Bellingham, W.A., C1

journal

The putative role of viruses, bacteria, and chronic fungal biotoxin exposure in the genesis of intractable fatigue accompanied by cognitive and physical disability

Gerwyn Morris, Prof Michael Berk, Prof Ken Walder, Prof Michael Maes

(2015), Vol. In press, pp. 1-22, Molecular neurobiology, Clifton, N.J., C1

journal

Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy

Mr Edward Patrick Callaly, Prof Ken Walder, Gerwyn Morris, Prof Michael Maes, Monojit Debnath, Prof Michael Berk

(2015), Vol. 15, pp. 355-365, Mini-reviews in medicinal chemistry, Amsterdam, The Netherlands, C1

journal

Lipid abundance in zebrafish embryos is regulated by complementary actions of the endocannabinoid system and retinoic acid pathway

Mr Daniel Fraher, Ms Megan Ellis, Ms Shona Morrison, A/Prof Sean Mcgee, Prof Alister Ward, Prof Ken Walder, Dr Yann Gibert

(2015), Vol. 156, pp. 3596-3609, Endocrinology, Bethesda, Md., C1

journal

Wireless optogenetics: an exploration of portable microdevices for small animal photostimulation

Mr Rajas Kale, Prof Abbas Kouzani, Prof Michael Berk, Prof Ken Walder, Julian Berk, Dr Susannah Tye

(2015), Vol. 20, pp. 225-230, Procedia technology, Amsterdam, The Netherlands, C1

journal

Prevalence of beak and feather disease virus in wild Platycercus elegans: comparison of three tissue types using a probe-based real-time qPCR test

Mr Justin Eastwood, Dr Mathew Berg, Ms Briana Spolding, Prof Kate Buchanan, Prof Andy Bennett, Prof Ken Walder

(2015), Vol. 63, pp. 1-8, Australian journal of zoology, Clayton, Vic., C1

journal
2014

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli Sand Rat)

Ms Briana Spolding, Mr Timothy Connor, Carrie Wittmer, Mrs Lelia Lelis Ferreira De Abreu, Antony Kaspi, Mark Ziemann, Dr Gunveen Kaur, Mr Adrian Cooper, Ms Shona Morrison, Mr Scott Lee, Prof Andrew Sinclair, Dr Yann Gibert, James Trevaskis, Jonathon Roth, A/Prof Assam El-Osta, Dr Richard Standish, Prof Ken Walder

(2014), Vol. 9, pp. 1-7, PLoS one, San Francisco, Calif., C1

journal

Non-referenced genome assembly from epigenomic short-read data

Antony Kaspi, Mark Ziemann, Samuel T Keating, Ishant Khurana, Mr Timothy Connor, Ms Briana Spolding, Mr Adrian Cooper, Ross Lazarus, Prof Ken Walder, Prof Paul Zimmet, A/Prof Assam El-Osta

(2014), Vol. 9, pp. 1329-1338, Epigenetics, New York, United States, C1

journal

Efficacy and safety of oral methazolamide in patients with type 2 diabetes : a 24-week, placebo-controlled, double-blind study

Richard J. Simpson, Prof Geoffrey Nicholson, Joseph Proietto, Ms Alana Sarah, Kerrie Margaret Sanders, Gabrielle Phillips, Jo Chambers, Dr Rob Macginley, Capr Neil Orford, Prof Ken Walder, Dr Guy Krippner, Kathy Skoff, Vincent J. Wacher

(2014), Vol. 37, pp. 3121-3123, Diabetes Care, Alexandria VA., C1

journal

Genetic variation associated with hypersensitivity to mercury.

A/Prof David Austin, Ms Briana Spolding, Shakuntla Gondalia, Kerrie A. Shandley, Enzo A. Palombo, Simon R. Knowles, Prof Ken Walder

(2014), Vol. 21, pp. 236-241, Toxicology International, India, C1-1

journal

Phylogenetic analysis of beak and feather disease virus across a host ring-species complex

Mr Justin Eastwood, Dr Mathew Berg, Dr Raoul Ribot, A/Prof Shane Raidal, Prof Kate Buchanan, Prof Ken Walder, Prof Andy Bennett

(2014), Vol. 111, pp. 14153-14158, Proceedings of the national scademy of sciences of the USA, Washington, DC, C1

journal
2013

Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells

Hemant Kulkarni, Harald H. H. Goring, Joanne Curran, Vincent Diego, Thomas D Dyer, Shelley A. Cole, Prof Ken Walder, Prof Gregory Collier, John Blangero, Melanie A. Carless

(2013), Vol. 71, pp. 1095-1100, Cancer chemotherapy and pharmacology, Heidelberg, Germany, C1

journal

Targeted multimodal liposomes for nano-delivery and imaging: an avenger for drug resistance and cancer.

Ms Sneha Gurudevan, Dr Rupinder Kanwar, Rakesh N Veedu, Sreenivasan Sasidharan, Richard L. Kennedy, Prof Ken Walder, Neeli Prasad, Prof Jagat Kanwar

(2013), Vol. 13, pp. 322-334, Current gene therapy, Bussum, The Netherlands, C1

journal

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

Mr Adam Walker, Sandy A Burnett, Ms Kyoko Hasebe, Prof Jane McGillivray, Dr Laura Gray, A/Prof Sean Mcgee, Prof Ken Walder, Prof Michael Berk, Dr Susannah Tye

(2013), Vol. 242, pp. 76-83, Behavioural brain research, Amsterdam, The Netherlands, C1

journal
2012

The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes

Dr Kristy Bolton, Dr David Segal, Prof Ken Walder

(2012), Vol. 6, pp. 67-72, Biologics : targets and therapy, Auckland, New Zealand, C1

journal

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo

Dr Nicky Konstantopoulos, Dr Juan Carlos Molero-Navajas, A/Prof Sean Mcgee, Ms Briana Spolding, Mr Timothy Connor, Ms Melissa de Vries, Mr Stephen Wanyonyi, Mr Richard Fahey, Ms Shona Morrison, Mrs Courtney Swinton, Ms Sharon Jones, Mr Adrian Cooper, Ms Lucia Garcia-Guerra, Dr Torie Foletta, Dr Guy Krippner, S Andrikopoulos, Prof Ken Walder

(2012), Vol. 61, pp. 2146-2154, Diabetes, Alexandria, Va., C1

journal

Design of a miniature UHF PIFA for DBS implants

Mr Kamal Hosain, Prof Abbas Kouzani, Dr Susannah Tye, Prof Ken Walder, Prof Lingxue Kong

(2012), pp. 485-489, CME 2012 : Proceedings of the 2012 IEEE/ICME International Conference on Complex Medical Engineering, Los Alamitos, Calif., E1

conference

Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines

Hemant Kulkarni, Harald H. H. Goring, Vincent Diego, Shelley A. Cole, Prof Ken Walder, Prof Gregory Collier, John Blangero, Melanie A. Carless

(2012), Vol. 5, pp. 1-12, BMC medical genomics, London, England, C1

journal

Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass

Nicola K. Cummings, Kate Shields, Joanne Curran, Dr Kiymet Bozaoglu, James Trevaskis, Kristi Gluschenko, Guowen Cai, Anthony G. Comuzzie, Thomas D Dyer, Prof Ken Walder, Prof Paul Zimmet, Prof Gregory Collier, John Blangero, Dr Jeremy Jowett

(2012), Vol. 36, pp. 201-206, International journal of obesity, London, England, C1

journal
2011

A head mountable deep brain stimulation device for laboratory animals

Prof Abbas Kouzani, Dr Susannah Tye, Prof Ken Walder, Prof Lingxue Kong

(2011), pp. 275-280, Advances in computer, communication, control and automation, Berlin, Germany, B1

chapter

Deficiency in interferon-y results in reduced body weight and better glucose tolerance in mice

Nicole Wong, Barbara C. Fam, Gitta R. Cempako, Dr Gregory Steinberg, Prof Ken Walder, Thomas W. Kay, Joe Proietto, S Andrikopoulos

(2011), Vol. 152, pp. 3690-3699, Endocrinology, Chevy Chase, Md., C1

journal

A gene expression signature for insulin resistance

Dr Nicky Konstantopoulos, Dr Torie Foletta, Dr David Segal, Kate Shields, Mr Andrew Sanigorski, Dr Kelly Windmill, Mrs Courtney Swinton, Mr Timothy Connor, Mr Stephen Wanyonyi, Thomas D Dyer, Mr Richard Fahey, Rose A. Watt, Joanne Curran, Dr Juan Carlos Molero-Navajas, Dr Guy Krippner, Prof Gregory Collier, Prof David E James, John Blangero, Dr Jeremy Jowett, Prof Ken Walder

(2011), Vol. 43, pp. 110-120, Physiological genomics, Bethesda, Md., C1

journal
2010

Regulation of skeletal muscle oxidative capacity and insulin signaling by the Mitochondrial Rhomboid Protease PARL

Mr Anthony Civitarese, Paul S. MacLean, Stacy Carling, Ms Lyndal Bayles, Ryan P. McMillan, Anson Pierce, Thomas C. Becker, Cedric Moro, Jean Finlayson, Natalie Lefort, Christopher B. Newgard, L Mandarino, William Cefalu, Prof Ken Walder, Prof Gregory Collier, Matthew W. Hulver, Mr Steven Smith, Eric Ravussin

(2010), Vol. 11, pp. 412-426, Cell metabolism, Cambridge, Mass., C1

journal

Chemerin, a novel adipokine in the regulation of angiogenesis

Dr Kiymet Bozaoglu, Joanne Curran, Claire J. Stocker, Mohamed S. Zaibi, Dr David Segal, Dr Nicky Konstantopoulos, Ms Shona Morrison, Melanie A. Carless, Thomas D Dyer, Shelley A. Cole, Harald H. H. Goring, Eric K Moses, Prof Ken Walder, Michael A. Cawthorne, John Blangero, Dr Jeremy Jowett

(2010), Vol. 95, pp. 2476-2485, Journal of clinical endocrinology & metabolism, Chevy Chase, Md., C1

journal

The characterisation of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome

Mr Matthew Prior, Dr Torie Foletta, Dr Jeremy Jowett, Dr David Segal, Melanie A. Carless, Joanne Curran, Thomas D Dyer, Eric K Moses, Andrew J. McAinch, Dr Nicky Konstantopoulos, Dr Kiymet Bozaoglu, Prof Gregory Collier, A/Prof David Cameron-Smith, John Blangero, Prof Ken Walder

(2010), Vol. 59, pp. 1057-1064, Metabolism, Philadelphia, Pa., C1

journal

Effects of rosiglitazone on intramyocellular lipid accumulation in Psammomys obesus

Dr Juan Carlos Molero-Navajas, Mr Scott Lee, Ilit Leizerman, Ayelet Chajut, Mr Adrian Cooper, Prof Ken Walder

(2010), Vol. 1802, pp. 235-239, B B A - Molecular Basis of Disease, Amsterdam, The Netherlands, C1

journal

Genetic variation in PARL influences mitochondrian content

Joanne Curran, Dr Jeremy Jowett, Lawrence J. Abraham, Luke A Diepeveen, Kate Elliott, Thomas D Dyer, Ms Lyndal Bayles, Matthew P Johnson, Anthony G. Comuzzie, Eric K Moses, Prof Ken Walder, Prof Gregory Collier, John Blangero, Dr Ahmed Kissebah

(2010), Vol. 127, pp. 183-190, Human genetics, Heidelberg, Germany, C1

journal
2009

Enhanced proliferation of human skeletal muscle precursor cells derived from elderly donors cultured in estimated physiological (5%) oxygen

Miss Sheree Martin, Dr Fiona Collier, Prof Mark Kirkland, Prof Ken Walder, Dr Nicole Stupka

(2009), Vol. 61, pp. 93-107, Cytotechnology: international journal of cell culture and biotechnology, Dordrecht, Netherlands, C1

journal

RTKN2 induces NF-KappaB dependent resistance to intrinsic apoptosis in HEK cells and REgulates BCL-2 genes in human CD4+ lymphocytes

Dr Fiona Collier, Andrea Loving, Adele J. Baker, Janet McLeod, Prof Ken Walder, Prof Mark Kirkland

(2009), Vol. 2, pp. 9-23, Journal of cell death, Auckland, New Zealand, C1

journal

Identification of secreted proteins associated with obesity and type 2 diabetes in Psammomys obesus

Dr Kristy Bolton, Dr David Segal, Dr Janine Mc Millan, Mr Andrew Sanigorski, Prof Gregory Collier, Prof Ken Walder

(2009), Vol. 33, pp. 1-13, International journal of obesity, Hampshire, England, C1

journal

Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity

Hua Su, Jennifer H. Gunter, Ms Melissa de Vries, Mr Timothy Connor, Mr Stephen Wanyonyi, Felicity S. Newell, Dr David Segal, Dr Juan Carlos Molero-Navajas, Ofer Reizes, Johannes B. Prins, Louise J Hutley, Prof Ken Walder, Jonathan P. Whitehead

(2009), Vol. 386, pp. 351-355, Biochemical and biophysical research communications, San Diego, Calif., C1

journal

NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors

Dr Torie Foletta, Mr Matthew Prior, Dr Nicole Stupka, Dr Kate Carey (nee Mehan), Dr David Segal, Ms Sharon Jones, Mrs Courtney Swinton, Miss Sheree Martin, A/Prof David Cameron-Smith, Prof Ken Walder

(2009), Vol. 587, pp. 1619-1634, Journal of physiology, Oxford, England, C1

journal

Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population

Dr Kiymet Bozaoglu, Dr David Segal, Kate Shields, Nicola K. Cummings, Joanne Curran, Anthony G. Comuzzie, Michael C. Mahaney, David L. Rainwater, John L. Vandenberg, Jean W. MacCluer, Prof Gregory Collier, John Blangero, Prof Ken Walder, Dr Jeremy Jowett

(2009), Vol. 94, pp. 3085-3088, The Journal of Clinical Endocrinology & Metabolism, Philadelphia, PA, C1

journal
2008

Decorin is a secreted protein associated with obesity and type 2 diabetes

Dr Kristy Bolton, Dr David Segal, Dr Janine Mc Millan, Dr Jeremy Jowett, Leonie K Heilbronn, K Abberton, Prof Paul Zimmet, D Chisholm, Prof Gregory Collier, Prof Ken Walder

(2008), Vol. 32, pp. 1113-1121, International journal of obesity, London, England, C1-1

journal
2007

Chemerin is a novel adipokine associated with obesity and metabolic syndrome

Dr Kiymet Bozaoglu, Dr Kristy Bolton, Dr Janine Mc Millan, Prof Paul Zimmet, Dr Jeremy Jowett, Prof Gregory Collier, Prof Ken Walder, Dr David Segal

(2007), Vol. 148, pp. 4687-4694, Endocrinology, Los Angeles, Calif., C1

journal

Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells

Dr Yuan Gao, Ms Joanne Pagnon, Helen Feng, Dr Nicky Konstantopoulos, Dr Jeremy Jowett, Prof Ken Walder

(2007), Vol. 356, pp. 636-641, Biochemical and biophysical research communications, Orlando, Fla., C1

journal

Localization and expression of selenoprotein S in the testis of Psammomys obesus

Dr Kelly Windmill, Dr Janette Tenne-Brown, Dr Richard Bayles, James Trevaskis, Dr Yuan Gao, Prof Ken Walder

(2007), Vol. 38, pp. 97-101, Journal of molecular histology, Amsterdam, The Netherlands, C1

journal

SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis

Kee-Hong Kim, Dr Yuan Gao, Prof Ken Walder, Prof Gregory Collier, Joseph Skelton, Dr Ahmed Kissebah

(2007), Vol. 354, pp. 127-132, Biochemical and biophysical research communications, Orlando, Fla., C1

journal
2006

Association of genetic vatiation within UBL5 with phenotypes of metabolic syndrome

Dr Kiymet Bozaoglu, Joanne Curran, Kate Elliott, Prof Ken Walder, Thomas D Dyer, David L. Rainwater, John L. Vandenberg, Anthony G. Comuzzie, Prof Gregory Collier, Prof Paul Zimmet, Jean W. MacCluer, Dr Jeremy Jowett, John Blangero

(2006), Vol. 78, pp. 147-159, Human biology, Detroit, Mich., C1

journal

Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells

Dr Yuan Gao, Nicholas R F Hannan, Mr Stephen Wanyonyi, Dr Nicky Konstantopoulos, Ms Joanne Pagnon, Helen Feng, Dr Jeremy Jowett, Kee-Hong Kim, Prof Ken Walder, Prof Gregory Collier

(2006), Vol. 33, pp. 246-251, Cytokine, Amsterdam, The Netherlands, C1

journal

Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays

Dr Kate Carey (nee Mehan), Dr David Segal, Rueben Klein, Mr Andrew Sanigorski, Prof Ken Walder, Prof Gregory Collier, A/Prof David Cameron-Smith

(2006), Vol. 56, pp. 246-255, Pathology international, Carlton South, Vic, C1

journal
2005

Genetic variation in selenoprotein S influences inflammatory response

Joanne Curran, Dr Jeremy Jowett, Kate Elliott, Dr Yuan Gao, Kristi Gluschenko, Jiajun Wang, Dalia M Abel Azim, Guowen Cai, Michael C. Mahaney, Anthony G. Comuzzie, Thomas D Dyer, Prof Ken Walder, Prof Paul Zimmet, Jean W. MacCluer, Prof Gregory Collier, Dr Ahmed Kissebah, John Blangero

(2005), Vol. 37, pp. 1234-1241, Nature, New York, N.Y., C1-1

journal

PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

Robert J. Southgate, A/Prof Clinton Bruce, Andrew L. Carey, Dr Gregory Steinberg, Prof Ken Walder, Robert Monks, Mr Matthew Watt, John A. Hawley, Morris J. Birnbaum, Prof Mark Febbraio

(2005), Vol. 19, pp. 2072-2074, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal

Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance

James Trevaskis, Prof Ken Walder, Dr Torie Foletta, Ms Lyndal Bayles, Dr Janine Mc Millan, Mr Adrian Cooper

(2005), Vol. 146, pp. 3757-3764, Endocrinology, Philadelphia, Pa., C1-1

journal

The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes

Prof Ken Walder, Ms Lyndal Bayles, Mr Anthony Civitarese, Dr Jeremy Jowett, Joanne Curran, Kate Elliott, James Trevaskis, Ms Natalie Bishara, Prof Paul Zimmet, L Mandarino, Eric Ravussin, John Blangero, Dr Ahmed Kissebah, Prof Gregory Collier

(2005), Vol. 48, pp. 459-468, Diabetologia, Berlin , Germany, C1

journal
2004

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

Dr Juan Carlos Molero-Navajas, Thomas E Jensen, Phil C Withers, Michelle Couzens, Herbert Herzog, Christine B. F. Thien, Wallace Y. Langdon, Prof Ken Walder, Maria A. Murphy, David D.L. Bowtell, Prof David E James, Gregory Cooney

(2004), Vol. 114, pp. 1326-1333, Journal of clinical investigation, New York, N.Y., C1

journal

Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2

Dr Fiona Collier, Tamara Gough, Courtney Talbot, Prof Ken Walder, Prof Mark Kirkland

(2004), Vol. 324, pp. 1360-1369, Biochemical and biophysical research communications, San Diego, Calif., C1

journal

Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein

Dr Yuan Gao, Helen Feng, Prof Ken Walder, Dr Kristy Bolton, T Sunderland, Ms Natalie Bishara, Miss Melissa Quick, Lakshmi Kantham, Prof Gregory Collier

(2004), Vol. 563, pp. 185-190, FEBS letters, Amsterdam, Netherlands, C1

journal

Identification of hypothalamic genes implicated in the development of obesity in Psammomys obesus using differential display PCR

James Trevaskis, Dr Janine Mc Millan, Dr Kelly Windmill, Prof Ken Walder, Prof Gregory Collier

(2004), Vol. 137, pp. 65-73, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, Tarrytown, N.Y., C1

journal

Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes

Dr Jeremy Jowett, Kate Elliott, Joanne Curran, Nicola Hunt, Prof Ken Walder, Prof Gregory Collier, Prof Paul Zimmet, John Blangero

(2004), Vol. 53, pp. 2467-2472, Diabetes, Alexandria, Va., C1

journal
2003

ORP3 splice variants and their expression in human tissues and hematopoietic cells

Dr Fiona Collier, J Apostolopoulos, Prof Ken Walder, Prof Mark Kirkland

(2003), Vol. 22, pp. 1-9, DNA and cell biology, New Rochelle, N.Y., C1-1

journal

Genetic studies in Psammomys obesus

Prof Ken Walder, Dr David Segal, Dr Jeremy Jowett, John Blangero, Prof Paul Zimmet, Prof Gregory Collier

(2003), Vol. 9, pp. 275-278, Progress in obesity research, Eastleigh, England, C1

journal

Obesity and diabetes gene discovery approaches

Prof Ken Walder, Dr David Segal, Dr Jeremy Jowett, John Blangero, Prof Gregory Collier

(2003), Vol. 9, pp. 1357-1372, Current pharmaceutical design, Schiphol, Netherlands, C1

journal

Elevation in tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells

Dr Yuan Gao, Prof Ken Walder, T Sunderland, Lakshmi Kantham, Helen Feng, Miss Melissa Quick, Ms Natalie Bishara, Dr Andrea Sanigorski, Guy Augert, Dr Janette Tenne-Brown, Prof Gregory Collier

(2003), Vol. 52, pp. 929-934, Diabetes, New York, N.Y., C1

journal

The taq IA and Ser311Cys polymorphisms in the dopamine D2 receptor gene and obesity

Adam G Southon, Prof Ken Walder, Dr Andrea Sanigorski, Prof Paul Zimmet, Prof Geoffrey Nicholson, A/Prof Mark Kotowicz, Prof Gregory Collier

(2003), Vol. 16, pp. 72-76, Diabetes, nutrition & metabolism, Milano, Italy, C1

journal

Beacon interacts with cdc2/cdc28-like kinases

Lakshmi Kantham, Ms Lyndal Bayles, Nathan Godde, Miss Melissa Quick, Ryan Webb, T Sunderland, Judy Bond, Prof Ken Walder, Guy Augert, Prof Gregory Collier

(2003), Vol. 304, pp. 125-129, Biochemical and biophysical research communications, New York, N.Y., C1

journal

Transcriptional profiling and gene discovery

Prof Gregory Collier, Dr Andrea Sanigorski, Dr Janette Tenne-Brown, Mr Andrew Sanigorski, Dr David Segal, Lakshmi Kantham, Prof Ken Walder

(2003), Vol. 9, pp. 36-39, Progress in obesity research, London, England, C1

journal
2002

Which genes are important in the development of type 2 diabetes?

Prof Gregory Collier, Prof Ken Walder, Dr Andrea De Silva-Sanigorski, Sally Morgan, Dr David Segal, Lakshmi Kantham, Guy Augert

(2002), pp. 175-186, Insulin resistance and insulin resistance syndrome, London, England, B1

chapter

A custom-built insulin resistance gene chip

Prof Ken Walder, Dr David Segal, Mr Sam Chehab, Guy Augert, A/Prof David Cameron-Smith, Prof Mark Hargreaves, Prof Gregory Collier

(2002), Vol. 967, pp. 274-282, Annals of the New York Academy of Sciences, New York, N.Y., C1

journal

Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes

Prof Ken Walder, E Ziv, R Kalman, K. Whitecross, E Shafrir, Prof Paul Zimmet, Prof Gregory Collier

(2002), Vol. 26, pp. 605-609, International journal of obesity, London, England, C1

journal

New approaches to gene discovery with animal models of obesity and diabetes

Prof Gregory Collier, Prof Ken Walder, Dr Andrea Sanigorski, Dr Janette Tenne-Brown, Mr Andrew Sanigorski, Dr David Segal, Lakshmi Kantham, Guy Augert

(2002), Vol. 967, pp. 403-413, Annals of the New York academy of science, New York, N.Y., C1

journal

Tanis: a link between type 2 diabetes and inflammation?

Prof Ken Walder, Lakshmi Kantham, Dr Janine Mc Millan, James Trevaskis, Ms Lyndal Bayles, Dr Andrea Sanigorski, T Sunderland, Nathan Godde, Dr Yuan Gao, Ms Natalie Bishara, Dr Kelly Windmill, Dr Janette Tenne-Brown, Guy Augert, Prof Paul Zimmet, Prof Gregory Collier

(2002), Vol. 51, pp. 1859-1866, Diabetes, New York, N.Y., C1

journal

Calpain 3 gene expression in skeletal muscle is associated with body fat content and measures of insulin resistance

Prof Ken Walder, Dr Janine Mc Millan, N Lapsys, A Kriketos, James Trevaskis, Mr Anthony Civitarese, Adam G Southon, Prof Paul Zimmet, Prof Gregory Collier

(2002), Vol. 26, pp. 442-449, International journal of obesity, London, England, C1

journal
2001

Genetic variation and obesity in Australian women: A prospective study.

Dr Andrea Sanigorski, Prof Ken Walder, E J Boyko, K. Whitecross, Prof Geoffrey Nicholson, M. Kolowitz, Jon Mark Pascoe, Prof Gregory Collier

(2001), Vol. 9, pp. 733-740, Obesity, Silver Spring, Md., C1

journal

Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats)

Prof Ken Walder, Dr Janine Mc Millan, Mr Scott Lee, Mr Anthony Civitarese, Prof Paul Zimmet, Prof Gregory Collier

(2001), Vol. 25, pp. 1281-1285, International journal of obesity, London, England, C1

journal
1997

The effect of dietary energy restriction on body weight gain and the development of noninsulin-dependent diabetes mellitus (NIDDM) in Psammomys obesus

Prof Ken Walder, Carolyn Dascaliuc, A/Prof Paul Lewandowski, Mr Andrew Sanigorski, Prof Paul Zimmet, Prof Gregory Collier

(1997), Vol. 5, pp. 193-200, Obesity research, London, England, C1-1

journal

Grants

Australian Competitive Grants

Characterisation of chemerin as a novel adipokine associated with obesity and metabolic syndrome

Prof Ken Walder, Dr Jeremy Jowett

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2008: $22,274
  • 2007: $22,274

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, Prof Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

ARC Linkage - Projects Rnd 1, ARC_DUAPAI ARC_Deakin University Australian Postgraduate Award Industry

  • 2013: $14,921
  • 2012: $183,043
  • 2011: $159,949
  • 2010: $153,111

Antidiabetic effects of a new secreted protein associated with type 2 diabetes

Prof Ken Walder

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2009: $26,054
  • 2008: $26,054

Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes

Prof Ken Walder, A/Prof Fred Pfeffer, Dr Nicky Konstantopoulos, Dr Guy Krippner

ARC Linkage - Projects Rnd 1

  • 2012: $139,973
  • 2011: $88,130
  • 2010: $86,763

The role of amyloid beta in insulin resistance

A/Prof Sean Mcgee, Prof Ken Walder, Prof Mark Hargreaves

NHMRC Project Grant

  • 2014: $125,826
  • 2013: $138,472
  • 2012: $136,023

Understanding the role of class IIa histone deacetylases in metabolic disease

A/Prof Sean Mcgee, Prof Ken Walder

NHMRC Project Grant

  • 2014: $164,086
  • 2013: $161,714
  • 2012: $143,600

Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction

Prof Andy Bennett, A/Prof Shane Raidal, Prof Marcel Klaassen, Prof Kate Buchanan, Prof Ken Walder, Dr Michael Magrath, Dr Yonatan Segal, Prof Martyn Jeggo

ARC Linkage - Projects

  • 2017: $10,803
  • 2016: $105,523
  • 2015: $112,909
  • 2014: $60,397

Gene Expression Signature Technology to Repurpose Drugs for Bipolar Disorder

Prof Ken Walder, Prof Michael Berk, Prof Marion Leboyer, Prof Brian Dean

NHMRC Project Grant

  • 2017: $26,248
  • 2016: $207,762
  • 2015: $117,544

Targeting bile acid receptors for the treatment of intestinal motility disorders and pain

Dr Leni Rivera, Prof Ken Walder

NHMRC ECF - Early Career Fellowship

  • 2016: $79,692
  • 2015: $39,979

Other Public Sector Funding

Global Gene Expression Analysis of 10 rat colon tissue samples

Prof Ken Walder

  • 2009: $16,666

Tissue distribution of RIPTAC in mice.

Prof Ken Walder

  • 2010: $18,000

Determination of RIPTAC bioavailability, pharmacokinetics and distribution

Prof Ken Walder, Mr Timothy Connor, Ms Briana Spolding

  • 2011: $12,000

Delivery of MIRNA Using Genetically Modified Influenza Virus

A/Prof John Stambas, Prof Alister Ward, Prof Ken Walder, Ms Yingju Xia

  • 2014: $60,000

Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction

Prof Andy Bennett, A/Prof Shane Raidal, Prof Marcel Klaassen, Prof Kate Buchanan, Prof Ken Walder, Dr Michael Magrath, Dr Yonatan Segal, Prof Martyn Jeggo

  • 2017: $25,000
  • 2016: $25,000
  • 2015: $30,000

Flourescent Cell Imager

Prof Ken Walder

  • 2014: $18,900

NHMRC Equipment Grant 2016 - Michael Berk

Prof Michael Berk, Prof Ken Walder

  • 2016: $17,691

Industry and Other Funding

Positional Candidate Genes Affecting Metabolic Syndrome

Dr Ahmed Kissebah, Prof Ken Walder

  • 2008: $83,444
  • 2007: $123,502
  • 2006: $96,944

Anti-inflammatory activity of mussel oil

Prof Ken Walder

  • 2009: $4,700

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, Prof Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

  • 2012: $70,607
  • 2011: $53,835
  • 2010: $52,910

Novel Therapies for the Treatment of Obesity

Prof Ken Walder

  • 2008: $2,133,334
  • 2007: $2,400,000
  • 2006: $2,420,000

Mechanism of action of VVP808

Prof Ken Walder

  • 2010: $17,740
  • 2009: $180,000

Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats

Prof Ken Walder

  • 2009: $72,500
  • 2008: $72,500

Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes

Prof Ken Walder, A/Prof Fred Pfeffer, Dr Nicky Konstantopoulos, Dr Guy Krippner

  • 2012: $127,200
  • 2011: $174,725
  • 2010: $146,043

Development of a rat model of acute pancreatitis

Prof Ken Walder

  • 2009: $80,000

Expression of Galanin receptors in Mouse, Rat and Human Pancreas

Prof Ken Walder

  • 2010: $6,500
  • 2009: $6,500

Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats

Prof Ken Walder

  • 2010: $72,500

Effects of amylin and leptin in sand rats

Prof Ken Walder

  • 2010: $36,132

Effects of novel insulin formulations on body weight and glucose homeostasis in Psammomy obesus

Prof Ken Walder

  • 2010: $17,000

New studies to investigate efficacy and safety of VVP808 (Part A)

Prof Ken Walder, Dr Nicky Konstantopoulos, Ms Briana Spolding, Mr Scott Lee

  • 2011: $90,000

Investigate and characterise VVP808 interacting proteins (Part B)

Prof Ken Walder

  • 2013: $8,681
  • 2012: $230,000
  • 2011: $160,000

VVP100X - Research Program: Novel analogues for the treatment of type 2 diabetes

Prof Ken Walder

  • 2012: $280,000
  • 2011: $70,000

The genetic basis of mercury sensitivity in pink disease survivors

A/Prof David Austin, Prof Ken Walder, Ms Shakuntla Gondalia, Kerrie Shandley, A/Prof Enzo Palombo, Dr Simon Knowles, Mr Matthew Garrecht

  • 2014: $9,074
  • 2013: $25,720
  • 2012: $18,389

Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats

Prof Ken Walder

  • 2014: $6,727
  • 2013: $6,727

Effects of encapsulation on bioavailability and distribution of orally administered milk lipid formulations

Prof Ken Walder

  • 2016: $82,899
  • 2014: $12,633

Beak and Feather Disease Virus in wild avian populations in Australia

Prof Andy Bennett, Dr Mathew Berg, Prof Ken Walder, Ms Johanne (Hanne) Marie Martens

  • 2016: $5,900

Other Funding Sources

Field-emission gun transmission electron microscope for the research in nanomaterials, metal alloys and biological sciences

Prof Ying (Ian) Chen, Prof Matthew Barnett, Prof Peter Hodgson, Prof Xungai Wang, Dr Takuya Tsuzuki, Dr Cui'E Wen, Dr Alexey Glushenkov, Prof Lingxue Kong, Prof Charles Sorrell, Dr Yuebin Zhang, Prof Vicki Chen, Dr Dominic Phelan, Prof Ken Walder, Dr Germanas Peleckis, A/Prof Simon Moulton, Prof John Beynon, Dr Xiaolin Wang, Prof David Cahill, Dr Pavel Cizek, Prof Neil Barnett, A/Prof Nicole Stanford, Prof Qipeng Guo

  • 2011: $230,000

Supervisions

Data will be available in 2017