Profile image of Ken Walder

Prof Ken Walder

STAFF PROFILE

Position

Chair In Metabolic Diseases

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy, Deakin University, 1998

Contact

ken.walder@deakin.edu.au
+61 3 522 72883

Biography

Professor Walder is the Chair of Metabolic Diseases in the School of Medicine and the Co-Director of IMPACT Institute. His research focuses on mental health disorders, and in particular the discovery of novel treatments for these diseases. After spending 2 years at the National Institutes of Health in Phoenix, Arizona, Professor Walder returned to Deakin University where he has played a key role in the evolution of the Metabolic Research Unit and the establishment of IMPACT Institute. He has authored more than 150 academic publications and is named as an inventor on more than 40 patent applications. Professor Walder has worked closely with a number of industry partners, and is focused on conducting applied research with tangible outcomes that benefit Australia. In 2014, a compound discovered in Professor Walder’s laboratory successfully completed a Phase 2 clinical trial for the treatment of type 2 diabetes. Current work is focused on using induced pluripotent stem cell technology to repurpose drugs to treat common mental health disorders including bipolar disorder, schizophrenia and major depressive disorder. Prof Walder also recently commenced a new project aiming to repurpose drugs to treat myalgic encephalomyelitis/chronic fatigue syndrome.

Read more on Ken's profile

Career highlights

Recent discovery of several drugs that can be repurposed for the treatment of bipolar disorder and schizophrenia.

Chief Investigator in the new NHMRC funded Centre of Research Excellence for the Development of Innovative Therapies for Psychiatric Disorders ($2.5M, 2019-2024).

A new drug for diabetes discovered in Prof Walder's laboratory successfully completed a phase 2 clinical trial, where it caused a significant reduction in plasma HbA1c levels (Simpson et al. Diabetes Care, 2014).

Research interests

Professor Walder's research is primarily focused on the discovery and validation of novel drug treatments for complex diseases. This research utilises state of the art equipment and technologies, in combination with unique model systems and sample collections, to screen for small molecules that can be used to treat complex diseases. The novel drug candidates are tested in in vitro and in vivo model systems to establish their potential for development as therapeutics.

Professor Walder works closely with the clinical research team at IMPACT, based at University Hospital Geelong, and has a strong focus on translating basic research findings into the clinical research program, with the overarching aim of improving the lives of people with mental health disorders.

Affiliations

Australasian Society for Bipolar and Depressive Disorders, International Society for Bipolar Disorders, Biological Psychiatry Australia, Society for Mental Health Research, World Federation of Societies of Biological Psychiatry

European Association for the Study of Diabetes, American Diabetes Association, Australian Diabetes Society, International Association for the Study of Obesity, North American Association for the Study of Obesity, Australian Society for the Study of Obesity
 

Teaching interests

Previously supervised 25 PhD and 32 Honours students to successful completions. 1 Current PhD student as Principal Supervisor, 4 as Associate Supervisor.

Unit Chair of HMH900 (Research Design)

Units taught

HMH900 (Research Design)

Knowledge areas

Mental health (major depressive disorder, bipolar disorder, schizophrenia).

Metabolic diseases (obesity, type 2 diabetes, non-alcoholic fatty liver disease).

Genetics.

Drug discovery.

Conferences

Invited presentations at national and international conferences including:

40th Annual Society for Mental Health Research Conference, Noosa, November 2018. Invited seminar presentation: "Targeting microRNAs to screen for new compounds to treat bipolar disorder".

Australasian Society for Bipolar & Depressive Disorders Conference, Melbourne, November 2017. "Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurogenesis and neurite outgrowth".

Biological Psychiatry Australia Annual Conference, Wooloongong, September 2016. "MicroRNA targets to repurpose drugs for bipolar disorder".

Australian Diabetes Society Annual Scientific Meeting, Sydney, August 2013. Invited seminar presentation: “VVP808 and fatty liver disease”.

Baker-IDI Research Institute Seminar Series, Melbourne, October 2011. Invited seminar presentation: “Use of GES technology to discover a new insulin sensitising agent”.

Frontiers in Obesity Research, Melbourne, September 2011. Invited seminar presentation: “VVP808: A novel insulin sensitising agent”.

University of Melbourne Department of Medicine Seminar Series, Melbourne, May 2010. Invited seminar presentation: “VVP808: A novel insulin sensitising agent”.

Monash University Obesity Diabetes Institute, Melbourne, June 2010. Invited seminar presentation: “Mechanism of action of VVP808”.

MSD Diabetes Meeting, Sydney, October 11-12, 2008. Symposium presentation: “Overview of mitochondrial dysfunction in diabetes”.

GTCbio 3rd Metabolic Diseases World Summit, San Diego, USA, November 1-2, 2007. Symposium presentation: “Use of gene expression signatures to discover novel diabetes therapeutics”.

ASSO 15th Annual Scientific Meeting, Canberra, Australia, August 31-September 2, 2007. Symposium presentation: “The adipocyte as an endocrine organ”.

2nd International Congress on Prediabetes and the Metabolic Syndrome, Barcelona, Spain, April 25-28, 2007. Symposium presentation: “The mitochondrial protease PARL and type 2 diabetes”.

2nd Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group, Kyoto, Japan, August 26-7, 2006. Symposium presentation: “CXS741, A Novel Secreted Protein Involved in the Pathogenesis of Obesity and Type 2 Diabetes”.

1st Scientific Meeting of the Asia-Pacific Diabetes and Obesity Study Group, Kobe, Japan, August 20-1, 2005. Symposium presentation: “Genetic variation in PSARL is associated with plasma insulin concentration”.

Professional activities

Professor Walder serves as a reviewer for the following journals:

Acta Neuropsychiatrica, Molecular Neurobiology, International Journal of Neuropsychopharmacology, Biological Psychiatry.

Diabetes, Diabetologia, International Journal of Obesity, Molecular and General Genetics, Kidney International, Pancreas

Professor Walder regularly reviews research applications for national and international funding bodies, including NHMRC and ARC.

Awards

1998 Fogarty Fellowship (NIH)

2006 Smart Geelong Network Biotechnology Researcher of the Year

Projects

See current School of Medicine Honours/PhD project booklet.

Current projects include:

Repurposing drugs to treat myalgic encephalomyelitis/chronic fatigue syndrome

Repurposing drugs to treat bipolar disorder

Novel microRNAs involved in the pathophysiology
and treatment of bipolar disorder

Alternative approaches in the treatment of bipolar disorder

Exploration of potential novel therapies for affective disorders

Publications

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2024

Use of gene regulatory network analysis to repurpose drugs to treat bipolar disorder

T Truong, Z Liu, B Panizzutti, O Dean, M Berk, J Kim, K Walder

(2024), Vol. 350, pp. 230-239, Journal of Affective Disorders, Netherlands, C1

journal article

Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity

L Hall, J Czeczor, T Connor, J Botella, K De Jong, M Renton, A Genders, K Venardos, S Martin, S Bond, K Aston-Mourney, K Howlett, J Campbell, G Collier, K Walder, M McKenzie, M Ziemann, S McGee

(2024), Vol. 15, pp. 1-13, Nature Communications, London, Eng., C1

journal article

Network-based drug repurposing for schizophrenia

T Truong, Z Liu, B Panizzutti, J Kim, O Dean, M Berk, K Walder

(2024), Neuropsychopharmacology, C1

journal article

The potential of baicalin to enhance neuroprotection and mitochondrial function in a human neuronal cell model

Z Liu, T Truong, C Bortolasci, B Spolding, B Panizzutti Parry, C Swinton, J Kim, D Hernández, S Kidnapillai, L Gray, M Berk, O Dean, K Walder

(2024), Molecular Psychiatry, Berlin, Germany, C1

journal article
2023

Metformin is Protective Against the Development of Mood Disorders

J Lake, C Bortolasci, A Stuart, J Pasco, S Kidnapillai, B Spolding, T Truong, B Panizzutti, Z Liu, O Dean, T Crowley, M Richardson, J Kim, M Berk, L Williams, K Walder

(2023), Vol. 56, pp. 25-31, Pharmacopsychiatry, C1

journal article

Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response

A Walker, M Mohebbi, M Maes, M Berk, K Walder, C Bortolasci, Z Liu, C Ng, M Ashton, L Berk, A Singh, G Malhi, O Dean

(2023), Vol. 27, Brain, Behavior, and Immunity - Health, C1

journal article

Identification of reversible and druggable pathways to improve beta-cell function and survival in Type 2 diabetes

S Sithara, T Crowley, K Walder, K Aston-Mourney

(2023), Vol. 15, pp. 2165368-, Islets, United States, C1

journal article

Alteration patterns of peripheral concentrations of cytokines and associated inflammatory proteins in acute and chronic stages of schizophrenia: a systematic review and network meta-analysis

S Halstead, D Siskind, M Amft, E Wagner, V Yakimov, Z Shih-Jung Liu, K Walder, N Warren

(2023), Vol. 10, pp. 260-271, The Lancet Psychiatry, Amsterdam, The Netherlands, C1-1

journal article

Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression

C Bortolasci, S Kidnapillai, B Spolding, T Truong, T Connor, C Swinton, B Panizzutti, Z Liu, A Sanigorski, O Dean, T Crowley, M Richardson, K Bozaoglu, K Vlahos, S Cowdery, B Watmuff, S Steyn, D Wolmarans, B Engelbrecht, C Perry, K Drummond, T Pang, S Jamain, L Gray, S McGee, B Harvey, J Kim, M Leboyer, M Berk, K Walder

(2023), Vol. 25, pp. 661-670, Bipolar Disorders, C1

journal article

Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis

B Panizzutti, D Skvarc, S Lin, S Croce, A Meehan, C Bortolasci, W Marx, A Walker, K Hasebe, B Kavanagh, M Morris, M Mohebbi, A Turner, L Gray, L Berk, K Walder, M Berk, O Dean

(2023), Vol. 24, International Journal of Molecular Sciences, C1-1

journal article

Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine

S Khanra, P Reddy, A Giménez-Palomo, C Park, B Panizzutti, M McCallum, S Arumugham, S Umesh, M Debnath, B Das, G Venkatasubramanian, M Ashton, A Turner, O Dean, K Walder, E Vieta, L Yatham, I Pacchiarotti, Y Reddy, N Goyal, M Kesavan, L Colomer, M Berk, J Kim

(2023), Vol. 28, pp. 3231-3242, Molecular Psychiatry, C1

journal article

Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance

S Masson, S Madsen, K Cooke, M Potter, A Vegas, L Carroll, S Thillainadesan, H Cutler, K Walder, G Cooney, G Morahan, J Stöckli, D James

(2023), Vol. 12, pp. 1-28, eLife, Cambridge, Eng., C1

journal article

A plasma protein signature associated with cognitive function in men without severe cognitive impairment

K Mehta, M Mohebbi, J Pasco, L Williams, S Sui, K Walder, B Ng, V Gupta

(2023), Vol. 15, pp. 1-13, Alzheimer's Research and Therapy, London, Eng., C1

journal article

Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management

M Berk, O Köhler-Forsberg, M Turner, B Penninx, A Wrobel, J Firth, A Loughman, N Reavley, J McGrath, N Momen, O Plana-Ripoll, A O'Neil, D Siskind, L Williams, A Carvalho, L Schmaal, A Walker, O Dean, K Walder, L Berk, S Dodd, A Yung, W Marx

(2023), Vol. 22, pp. 366-387, World Psychiatry, London, Eng., C1-1

journal article

CaMKK2 as an emerging treatment target for bipolar disorder

J Kaiser, K Nay, C Horne, L McAloon, O Fuller, A Muller, D Whyte, A Means, K Walder, M Berk, A Hannan, J Murphy, M Febbraio, A Gundlach, J Scott

(2023), pp. 1-12, Molecular Psychiatry, Berlin, Germany, C1

journal article

Impact of Mood Disorder History and Bone Health on Cognitive Function Among Men Without Dementia

Kanika Mehta, Mohammadreza Mohebbi, Julie Pasco, Lana Williams, Ken Walder, Boon Ng, Veer Gupta

(2023), pp. 1-13, Journal of Alzheimer's Disease, Netherlands, C1

journal article

Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen

C Bortolasci, E Jaehne, D Hernández, B Spolding, T Connor, B Panizzutti, O Dean, T Crowley, A Yung, L Gray, J Kim, M van den Buuse, M Berk, K Walder

(2023), Vol. 41, pp. 502-513, Neurotoxicity Research, C1

journal article

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

S Martin, T Connor, A Sanigorski, K McEwen, D Henstridge, B Nijagal, D De Souza, D Tull, P Meikle, G Kowalski, C Bruce, P Gregorevic, M Febbraio, F Collier, K Walder, S McGee

(2023), Vol. 14, pp. 1-13, Cell Death and Disease, Berlin, Germany, C1

journal article

Effects of antipsychotic drugs on energy metabolism

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, S Martin, T Truong, Z Liu, L Gray, G Kowalski, S McGee, J Kim, M Berk, K Walder

(2023), European Archives of Psychiatry and Clinical Neuroscience, Germany, C1

journal article
2022

Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders

G Morris, K Walder, M Berk, A Carvalho, W Marx, C Bortolasci, A Yung, B Puri, M Maes

(2022), Vol. 114, pp. 1-17, Progress in Neuro-Psychopharmacology and Biological Psychiatry, Amsterdam, The Netherlands, C1

journal article

Depression and bone loss as risk factors for cognitive decline: A systematic review and meta-analysis

K Mehta, S Thandavan, M Mohebbi, J Pasco, L Williams, K Walder, B Ng, V Gupta

(2022), Vol. 76, Ageing Research Reviews, C1

journal article

Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia

G Morris, L Sominsky, K Walder, M Berk, W Marx, A Carvalho, C Bortolasci, M Maes, B Puri

(2022), Vol. 59, pp. 3485-3503, Molecular Neurobiology, Berlin, Germany, C1

journal article

Common effects of bipolar disorder medications on expression quantitative trait loci genes

T Truong, C Bortolasci, S Kidnapillai, B Spolding, B Panizzutti, Z Liu, B Watmuff, J Kim, O Dean, M Richardson, M Berk, K Walder

(2022), Vol. 150, pp. 105-112, Journal of Psychiatric Research, C1

journal article

Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder

T Truong, C Bortolasci, B Spolding, B Panizzutti, Z Liu, S Kidnapillai, M Richardson, L Gray, C Smith, O Dean, J Kim, M Berk, K Walder

(2022), Vol. 13, Frontiers in Pharmacology, C1

journal article

Effects of Psychotropic Drugs on Ribosomal Genes and Protein Synthesis

Z Liu, T Truong, C Bortolasci, B Spolding, B Panizzutti, C Swinton, J Kim, S Kidnapillai, M Richardson, L Gray, O Dean, S McGee, M Berk, K Walder

(2022), Vol. 23, International Journal of Molecular Sciences, C1

journal article

Brain derived neurotrophic factor in perioperative neurocognitive disorders: Current evidence and future directions

N Travica, H Aslam, A O'Neil, M Lane, M Berk, E Gamage, K Walder, Z Liu, T Segasby, W Marx

(2022), Vol. 193, Neurobiology of Learning and Memory, C1

journal article

Integrative Analyses of Transcriptomes to Explore Common Molecular Effects of Antipsychotic Drugs

T Truong, C Bortolasci, S Kidnapillai, B Spolding, B Panizzutti, Z Liu, J Kim, O Dean, M Richardson, M Berk, K Walder

(2022), Vol. 23, International Journal of Molecular Sciences, C1

journal article

Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders

T Truong, B Panizzutti, J Kim, K Walder

(2022), Vol. 14, Pharmaceutics, C1

journal article

The role of metformin as a treatment for neuropsychiatric illness

S Dodd, L Sominsky, D Siskind, C Bortolasci, A Carvalho, M Maes, A Walker, K Walder, A Yung, L Williams, H Myles, T Watson, M Berk

(2022), Vol. 64, pp. 32-43, European Neuropsychopharmacology, Netherlands, C1

journal article

Genetic polymorphism in BIN1 rather than APOE is associated with poor recognition memory among men without dementia

K Mehta, M Mohebbi, J Pasco, L Williams, K Walder, B Ng, V Gupta

(2022), Vol. 12, Scientific Reports, C1

journal article
2021

Effects of psychoactive drugs on cellular bioenergetic pathways

C Bortolasci, B Spolding, S Kidnapillai, M Richardson, N Vasilijevic, S Martin, L Gray, S McGee, M Berk, K Walder

(2021), Vol. 22, pp. 79-93, World Journal of Biological Psychiatry, England, C1

journal article

Systemic inflammation and grey matter volume in schizophrenia and bipolar disorder: Moderation by childhood trauma severity

Y Quidé, C Bortolasci, B Spolding, S Kidnapillai, O Watkeys, S Cohen-Woods, V Carr, M Berk, K Walder, M Green

(2021), Vol. 105, Progress in Neuro-Psychopharmacology and Biological Psychiatry, England, C1

journal article

Chlamydial diversity and predictors of infection in a wild Australian parrot, the Crimson Rosella (Platycercus elegans)

H Stokes, J Martens, M Jelocnik, K Walder, Y Segal, M Berg, A Bennett

(2021), Vol. 68, pp. 487-498, Transboundary and Emerging Diseases, Germany, C1

journal article

Preventing the development of severe COVID-19 by modifying immunothrombosis

G Morris, C Bortolasci, B Puri, L Olive, W Marx, A O'Neil, E Athan, A Carvalho, M Maes, K Walder, M Berk

(2021), Vol. 264, Life Sciences, Netherlands, C1

journal article

Diet and depression: exploring the biological mechanisms of action

W Marx, M Lane, M Hockey, H Aslam, M Berk, K Walder, A Borsini, J Firth, C Pariante, K Berding, J Cryan, G Clarke, J Craig, K Su, D Mischoulon, F Gomez-Pinilla, J Foster, P Cani, S Thuret, H Staudacher, A Sánchez-Villegas, H Arshad, T Akbaraly, A O’Neil, T Segasby, F Jacka

(2021), Vol. 26, pp. 134-150, Molecular Psychiatry, England, C1

journal article

Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry

G Morris, A Walker, K Walder, M Berk, W Marx, A Carvalho, M Maes, B Puri

(2021), Vol. 58, pp. 2158-2182, Molecular Neurobiology, United States, C1

journal article

The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders

Gerwyn Morris, B Puri, C Bortolasci, Andre Carvalho, M Berk, K Walder, E Moreira, M Maes

(2021), Vol. 125, pp. 244-263, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

The endocannabinoid system and retinoic acid signaling combine to influence bone growth

D Fraher, R Mann, M Dubuisson, M Ellis, T Yu, K Walder, A Ward, C Winkler, Y Gibert

(2021), Vol. 529, Molecular and Cellular Endocrinology, Ireland, C1

journal article

Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response

G Morris, E Gamage, N Travica, M Berk, F Jacka, A O'Neil, B Puri, A Carvalho, C Bortolasci, K Walder, W Marx

(2021), Vol. 172, pp. 101-122, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal article

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, C Bortolasci, B Puri, W Marx, A O'Neil, E Athan, K Walder, M Berk, L Olive, A Carvalho, M Maes

(2021), Vol. 144, Cytokine, England, C1

journal article

The lipid paradox in neuroprogressive disorders: causes and consequences

Gerwyn Morris, M Berk, K Walder, A O'Neil, M Maes, B Puri

(2021), Vol. 128, pp. 35-57, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

G Morris, K Walder, S Kloiber, P Amminger, M Berk, C Bortolasci, M Maes, B Puri, A Carvalho

(2021), Vol. 170, Pharmacological Research, Netherlands, C1

journal article

Transcriptional modulation of the hippo signaling pathway by drugs used to treat bipolar disorder and schizophrenia

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, G Morris, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 22, International Journal of Molecular Sciences, C1

journal article

Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats

R Kale, T Nguyen, J Price, N Yates, K Walder, M Berk, R Sillitoe, A Kouzani, S Tye

(2021), Vol. 15, Frontiers in Human Neuroscience, Switzerland, C1

journal article

Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial

C Bortolasci, A Turner, M Mohebbi, Z Liu, M Ashton, L Gray, W Marx, A Walker, G Kowalski, F Jacka, M Berk, O Dean, K Walder

(2021), Vol. 142, pp. 376-383, Journal of Psychiatric Research, England, C1

journal article

Biological mechanism(S) underpinning the association between antipsychotic drugs and weight gain

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 10, Journal of Clinical Medicine, C1

journal article

Beak and feather disease virus and Chlamydiales infections in wild Australian psittacines: no statistical evidence for dependence

J Martens, H Stokes, M Berg, K Walder, Y Segal, M Magrath, A Bennett

(2021), Vol. 121, pp. 333-339, Emu, C1

journal article

Exploring interleukin-6, lipopolysaccharide binding protein and brain-derived neurotrophic factor following 12 weeks of adjunctive minocycline treatment for depression

K Hasebe, M Mohebbi, L Gray, A Walker, C Bortolasci, A Turner, M Berk, K Walder, M Maes, B Kanchanatawan, M Ashton, L Berk, C Ng, G Malhi, A Singh, O Dean

(2021), Vol. 34, Acta Neuropsychiatrica, England, C1

journal article
2020

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

S Kidnapillai, C Bortolasci, M Udawela, B Panizzutti, B Spolding, T Connor, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, E Scarr, M Leboyer, B Dean, M Berk, K Walder

(2020), Vol. 21, pp. 775-783, World Journal of Biological Psychiatry, England, C1

journal article

Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurite outgrowth

S Kidnapillai, B Wade, C Bortolasci, B Panizzutti, B Spolding, T Connor, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2020), Vol. 34, pp. 370-379, Journal of Psychopharmacology, United States, C1

journal article

Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis

C Bortolasci, W Marx, A Walker, K Hasebe, B Kavanagh, M Morris, M Mohebbi, A Turner, L Gray, L Berk, K Walder, M Berk, O Dean

(2020), Vol. 10, pp. e035080-, BMJ open, England, C1

journal article

Seasonal fluctuation of beak and feather disease virus (BFDV) infection in wild Crimson Rosellas (Platycercus elegans)

J Martens, H Stokes, M Berg, K Walder, A Bennett

(2020), Vol. 10, Scientific Reports, England, C1

journal article

A non-invasive method to assess environmental contamination with avian pathogens: beak and feather disease virus (BFDV) detection in nest boxes

J Martens, H Stokes, M Berg, K Walder, S Raidal, M Magrath, A Bennett

(2020), Vol. 2020, PeerJ, United States, C1

journal article

Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder

C Bortolasci, C Voigt, A Turner, M Mohebbi, L Gray, S Dodd, K Walder, M Berk, S Cotton, G Malhi, C Ng, N Dowling, J Sarris, O Dean

(2020), Vol. 32, pp. 313-320, Acta Neuropsychiatrica, England, C1

journal article

Beak and feather disease virus (BFDV) prevalence, load and excretion in seven species of wild caught common Australian parrots

J Martens, H Stokes, M Berg, K Walder, S Raidal, M Magrath, A Bennett

(2020), Vol. 15, PLoS ONE, United States, C1

journal article

Recombinant Balsamin induces apoptosis in liver and breast cancer cells via cell cycle arrest and regulation of apoptotic pathways

P Ajji, M Binder, K Walder, M Puri

(2020), Vol. 96, pp. 146-156, Process biochemistry, Amsterdam, The Netherlands, C1

journal article

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, C Bortolasci, B Puri, L Olive, W Marx, A O'Neil, E Athan, A Carvalho, M Maes, K Walder, M Berk

(2020), Vol. 258, Life Sciences, Netherlands, C1

journal article

Can endolysosomal deacidification and inhibition of autophagy prevent severe COVID-19?

G Morris, E Athan, K Walder, C Bortolasci, A O'Neil, W Marx, M Berk, A Carvalho, M Maes, B Puri

(2020), Vol. 262, Life Sciences, Netherlands, C1

journal article

Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments

G Morris, B Puri, L Olive, A Carvalho, M Berk, K Walder, L Gustad, M Maes

(2020), Vol. 18, BMC Medicine, England, C1

journal article

Transcriptional effects of psychoactive drugs on genes involved in neurogenesis

C Bortolasci, B Spolding, S Kidnapillai, T Connor, T Truong, Z Liu, B Panizzutti, M Richardson, L Gray, M Berk, O Dean, K Walder

(2020), Vol. 21, pp. 1-19, International Journal of Molecular Sciences, C1

journal article

Species, sex and geographic variation in chlamydial prevalence in abundant wild Australian parrots

H Stokes, J Martens, K Walder, Y Segal, M Berg, A Bennett

(2020), Vol. 10, Scientific Reports, England, C1

journal article

Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells

P Ajji, K Walder, M Puri

(2020), Vol. 11, Frontiers in Pharmacology, Switzerland, C1

journal article
2019

Prevalence of BFDV in wild breeding Platycercus elegans

J Eastwood, M Berg, R Ribot, K Buchanan, K Walder, A Bennett

(2019), Vol. 160, pp. 557-565, Journal of Ornithology, C1

journal article

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

M Ashton, O Dean, A Walker, C Bortolasci, C Ng, M Hopwood, B Harvey, M Möller, J McGrath, W Marx, A Turner, S Dodd, J Scott, J Khoo, K Walder, J Sarris, M Berk

(2019), Vol. 10, Frontiers in Psychiatry, Switzerland, C1

journal article

Identification of Chlamydia gallinacea in a parrot and in free-range chickens in Australia

H Stokes, J Martens, A Chamings, K Walder, M Berg, Y Segal, A Bennett

(2019), Vol. 97, pp. 398-400, Australian veterinary journal, Chichester, Eng., C1

journal article

The compensatory antioxidant response system with a focus on neuroprogressive disorders

G Morris, B Puri, A Walker, M Berk, K Walder, C Bortolasci, W Marx, A Carvalho, M Maes

(2019), Vol. 95, Progress in Neuro-Psychopharmacology and Biological Psychiatry, England, C1

journal article

Persistence of beak and feather disease virus (BFDV) infection in wild Crimson Rosellas (Platycercus elegans)

Johanne Martens, Helena Stokes, Justin Eastwood, Shane Raidal, Andrew Peters, Mathew Berg, Ken Walder, Michael Magrath, Andrew Bennett

(2019), Vol. 119, pp. 402-406, Emu - Austral ornithology, Abingdon, Eng., C1

journal article

Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

K Hasebe, L Rivera, C Smith, T Allnutt, T Crowley, T Nelson, O Dean, S McGee, K Walder, L Gray

(2019), Vol. 82, pp. 309-318, Brain, Behavior, and Immunity, Netherlands, C1

journal article

Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities

G Morris, B Puri, A Walker, M Maes, A Carvalho, K Walder, C Mazza, M Berk

(2019), Vol. 148, Pharmacological Research, Netherlands, C1

journal article

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis - a possible therapeutic mechanism

S Kidnapillai, C Bortolasci, B Panizzutti, B Spolding, T Connor, K Bonifacio, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2019), Vol. 20, pp. 766-777, World Journal of Biological Psychiatry, London, Eng., C1

journal article

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

G Morris, B Puri, A Walker, M Maes, A Carvalho, C Bortolasci, K Walder, M Berk

(2019), Vol. 107, pp. 862-882, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

ENACT: A protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis

S Cotton, M Berk, A Watson, S Wood, K Allott, C Bartholomeusz, C Bortolasci, K Walder, B O'Donoghue, O Dean, A Chanen, G Amminger, P McGorry, A Burnside, J Uren, A Ratheesh, S Dodd

(2019), Vol. 20, Trials, England, C1

journal article
2018

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

G Morris, K Walder, A Carvalho, S Tye, K Lucas, M Berk, M Maes

(2018), Vol. 84, pp. 453-469, Neuroscience and Biobehavioral Reviews, United States, C1

journal article

Mechanisms underpinning the polypharmacy effects of medications in psychiatry

C Bortolasci, B Spolding, E Callaly, S Martin, B Panizzutti, S Kidnapillai, T Connor, K Hasebe, M Mohebbi, O Dean, S McGee, S Dodd, L Gray, M Berk, K Walder

(2018), Vol. 21, pp. 582-591, International Journal of Neuropsychopharmacology, England, C1

journal article

Purification and functional characterization of recombinant balsamin, a ribosome-inactivating protein from Momordica balsamina

Parminder Ajji, Shailendra Sonkar, Ken Walder, Munish Puri

(2018), Vol. 114, pp. 226-234, International journal of biological macromolecules, Amsterdam, The Netherlands, C1

journal article

The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications

G Morris, B Puri, K Walder, M Berk, B Stubbs, M Maes, A Carvalho

(2018), Vol. 55, pp. 8765-8787, Molecular Neurobiology, United States, C1

journal article

Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression

J Price, Carrie Bronars, Sophie Erhardt, Kathyrn Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean McGee, Mark Frye, Susannah Tye

(2018), Vol. 90, pp. 212-220, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

J Czeczor, A Genders, K Aston-Mourney, T Connor, L Hall, K Hasebe, M Ellis, K De Jong, D Henstridge, P Meikle, M Febbraio, K Walder, S McGee

(2018), Vol. 237, pp. 311-322, Journal of Endocrinology, England, C1

journal article

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis

G Morris, B Stubbs, C Köhler, K Walder, A Slyepchenko, M Berk, A Carvalho

(2018), Vol. 41, pp. 255-265, Sleep Medicine Reviews, England, C1

journal article

Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring

A Kaspi, I Khurana, M Ziemann, T Connor, B Spolding, P Zimmet, K Walder, A El-Osta

(2018), Vol. 62, Molecular Nutrition and Food Research, Germany, C1

journal article

Pair fidelity in long-lived parrots: genetic and behavioural evidence from the Crimson Rosella ( Platycercus elegans )

Justin Eastwood, Mathew Berg, Raoul Ribot, Helena Stokes, Johanne Martens, Katherine Buchanan, Ken Walder, Andrew Bennett

(2018), Vol. 118, pp. 369-374, Emu: Austral ornithology, Abingdon, Eng., C1

journal article

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

B Panizzutti, C Bortolasci, K Hasebe, S Kidnapillai, L Gray, K Walder, M Berk, M Mohebbi, S Dodd, C Gama, P Magalhães, S Cotton, F Kapczinski, A Bush, G Malhi, O Dean

(2018), Vol. 30, pp. 334-341, Acta Neuropsychiatrica, England, C1

journal article

Psammomys obesus: a Natural Diet-Controlled Model for Diabetes and Cardiovascular Diseases

R Chaudhary, K Walder, C Hagemeyer, J Kanwar

(2018), Vol. 20, Current Atherosclerosis Reports, United States, C1

journal article
2017

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

G Morris, M Berk, H Klein, K Walder, P Galecki, M Maes

(2017), Vol. 54, pp. 4271-4291, Molecular Neurobiology, United States, C1

journal article

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

G Morris, M Berk, A Carvalho, J Caso, Y Sanz, K Walder, M Maes

(2017), Vol. 54, pp. 4432-4451, Molecular Neurobiology, United States, C1

journal article

Gene expression signature: A powerful approach for drug discovery in diabetes

S Sithara, T Crowley, K Walder, K Aston-Mourney

(2017), Vol. 232, pp. R131-R139, Journal of Endocrinology, England, C1

journal article

A model of the mitochondrial basis of bipolar disorder

G Morris, K Walder, S McGee, O Dean, S Tye, M Maes, M Berk

(2017), Vol. 74, pp. 1-20, Neuroscience and Biobehavioral Reviews, United States, C1

journal article

Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

V Gaur, T Connor, K Venardos, D Henstridge, S Martin, C Swinton, S Morrison, K Aston-Mourney, S Gehrig, R van Ewijk, G Lynch, M Febbraio, G Steinberg, M Hargreaves, K Walder, S McGee

(2017), Vol. 19, pp. 936-943, Diabetes, Obesity and Metabolism, England, C1

journal article

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

journal article

Adjunctive N-acetylcysteine in depression: Exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

K Hasebe, L Gray, C Bortolasci, B Panizzutti, M Mohebbi, S Kidnapillai, B Spolding, K Walder, M Berk, G Malhi, S Dodd, O Dean

(2017), Vol. 29, pp. 337-346, Acta Neuropsychiatrica, England, C1

journal article

Exercise and the skeletal muscle epigenome

S McGee, K Walder

(2017), Vol. 7, Cold Spring Harbor Perspectives in Medicine, United States, C1

journal article

Balsamin induces apoptosis in breast cancer cells via DNA fragmentation and cell cycle arrest

P Ajji, M Binder, K Walder, M Puri

(2017), Vol. 432, pp. 189-198, Molecular and Cellular Biochemistry, Netherlands, C1

journal article

Validation of a Portable Low-Power Deep Brain Stimulation Device Through Anxiolytic Effects in a Laboratory Rat Model

A Kouzani, R Kale, P Zarate-Garza, M Berk, K Walder, S Tye

(2017), Vol. 25, pp. 1365-1374, IEEE Transactions on Neural Systems and Rehabilitation Engineering, United States, C1

journal article

Hypothalamic gene expression is regulated by DNA methylation linking parental diet during pregnancy to offspring's risk of obesity in psammomys obesus

I Khurana, A Kaspi, M Ziemann, T Block, T Connor, B Spolding, A Cooper, P Zimmet, A El-Osta, K Walder

(2017), Vol. 49, pp. S103-S104, Pathology, Amsterdam, The Netherlands, C1

journal article
2016

The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases

G Morris, M Berk, P Galecki, K Walder, M Maes

(2016), Vol. 53, pp. 1195-1219, Molecular Neurobiology, United States, C1

journal article

The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability

G Morris, M Berk, K Walder, M Maes

(2016), Vol. 53, pp. 2550-2571, Molecular Neurobiology, United States, C1

journal article

The deleterious effects of oxidative and nitrosative stress on palmitoylation, membrane lipid rafts and lipid-based cellular signalling : new drug targets in neuroimmune disorders

G Morris, K Walder, B Puri, M Berk, M Maes

(2016), Vol. 53, pp. 4638-4658, Molecular neurobiology, New York, N.Y., C1

journal article

Citalopram and sertraline exposure compromises embryonic bone development

D Fraher, J Hodge, F Collier, J McMillan, R Kennedy, M Ellis, G Nicholson, K Walder, S Dodd, M Berk, J Pasco, L Williams, Y Gibert

(2016), Vol. 21, pp. 656-664, Molecular Psychiatry, England, C1

journal article

Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents

R Chaudhary, K Roy, R Kanwar, K Walder, J Kanwar

(2016), Vol. 14, Journal of Nanobiotechnology, England, C1

journal article

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

M Coughlan, G Higgins, T Nguyen, S Penfold, V Thallas-Bonke, S Tan, G Ramm, N Van Bergen, D Henstridge, K Sourris, B Harcourt, I Trounce, P Robb, A Laskowski, S McGee, A Genders, K Walder, B Drew, P Gregorevic, H Qian, M Thomas, G Jerums, R Macisaac, A Skene, D Power, E Ekinci, X Wijeyeratne, L Gallo, M Herman-Edelstein, M Ryan, M Cooper, D Thorburn, J Forbes

(2016), Vol. 65, pp. 1085-1098, Diabetes, United States, C1

journal article

DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus

I Khurana, A Kaspi, M Ziemann, T Block, T Connor, B Spolding, A Cooper, P Zimmet, A El-Osta, K Walder

(2016), Vol. 40, pp. 1079-1088, International Journal of Obesity, England, C1

journal article

Functional analysis of a Type-I ribosome inactivating protein balsamin from Momordica balsamina with anti-microbial and DNase activity

P Ajji, K Walder, M Puri

(2016), Vol. 71, pp. 265-271, Plant foods for human nutrition, New York, N.Y., C1

journal article

Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

Y Kim, S McGee, J Czeczor, A Walker, R Kale, A Kouzani, K Walder, M Berk, S Tye

(2016), Vol. 6, pp. e842-, Translational psychiatry, United States, C1

journal article

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell Reports, United States, C1

journal article

Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate

B Hayward, J Molero, K Windmill, A Sanigorski, J Weir, N McRae, K Aston-Mourney, B Osborne, B Liao, K Walder, P Meikle, N Konstantopoulos, C Schmitz-Peiffer

(2016), Vol. 124, pp. 602-612, Experimental and Clinical Endocrinology and Diabetes, Germany, C1

journal article
2015

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.

L Zabeau, C Jensen, S Seeuws, K Venken, A Verhee, D Catteeuw, G van Loo, H Chen, K Walder, J Hollis, S Foote, M Morris, J Van der Heyden, F Peelman, B Oldfield, J Rubio, D Elewaut, J Tavernier

(2015), Vol. 72, pp. 629-644, Cellular and Molecular Life Sciences, Switzerland, C1

journal article

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

G Morris, M Berk, K Walder, M Maes

(2015), Vol. 13, pp. 1-23, BMC Medicine, London, Eng., C1

journal article

Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy

E Callaly, K Walder, G Morris, M Maes, M Debnath, M Berk

(2015), Vol. 15, pp. 355-365, Mini-reviews in medicinal chemistry, Amsterdam, The Netherlands, C1

journal article

Prevalence of beak and feather disease virus in wild Platycercus elegans: comparison of three tissue types using a probe-based real-time qPCR test

J Eastwood, M Berg, B Spolding, K Buchanan, A Bennett, K Walder

(2015), Vol. 63, pp. 1-8, Australian journal of zoology, Clayton, Vic., C1

journal article

Evolution of optogenetic microdevices

R Kale, A Kouzani, K Walder, M Berk, S Tye

(2015), Vol. 2, pp. 1-11, Neurophotonics, Bellingham, W.A., C1

journal article

Lipid abundance in zebrafish embryos is regulated by complementary actions of the endocannabinoid system and retinoic acid pathway

D Fraher, M Ellis, S Morrison, S McGee, A Ward, K Walder, Y Gibert

(2015), Vol. 156, pp. 3596-3609, Endocrinology, Bethesda, Md., C1

journal article

CXCR4 Antagonism attenuates the development of diabetic cardiac fibrosis

P Chu, K Walder, D Horlock, D Williams, E Nelson, M Byrne, K Jandeleit-Dahm, P Zimmet, D Kaye

(2015), Vol. 10, pp. 1-13, PLoS One, San Francisco, CA, C1

journal article

Wireless optogenetics: an exploration of portable microdevices for small animal photostimulation

R Kale, A Kouzani, M Berk, K Walder, J Berk, S Tye

(2015), Vol. 20, pp. 225-230, Procedia technology, Amsterdam, The Netherlands, C1

journal article
2014

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli Sand Rat)

B Spolding, T Connor, C Wittmer, L Abreu, A Kaspi, M Ziemann, G Kaur, A Cooper, S Morrison, S Lee, A Sinclair, Y Gibert, J Trevaskis, J Roth, A El-Osta, R Standish, K Walder

(2014), Vol. 9, pp. 1-7, PLoS one, San Francisco, Calif., C1

journal article

Phylogenetic analysis of beak and feather disease virus across a host ring-species complex

J Eastwood, M Berg, R Ribot, S Raidal, K Buchanan, K Walder, A Bennett

(2014), Vol. 111, pp. 14153-14158, Proceedings of the national scademy of sciences of the USA, Washington, DC, C1

journal article

Efficacy and safety of oral methazolamide in patients with type 2 diabetes : a 24-week, placebo-controlled, double-blind study

R Simpson, G Nicholson, J Proietto, A Sarah, K Sanders, G Phillips, J Chambers, R MacGinley, N Orford, K Walder, G Krippner, K Skoff, V Wacher

(2014), Vol. 37, pp. 3121-3123, Diabetes Care, Alexandria VA., C1

journal article

Non-referenced genome assembly from epigenomic short-read data

A Kaspi, M Ziemann, S Keating, I Khurana, T Connor, B Spolding, A Cooper, R Lazarus, K Walder, P Zimmet, A El-Osta

(2014), Vol. 9, pp. 1329-1338, Epigenetics, United States, C1

journal article

Genetic variation associated with hypersensitivity to mercury.

D Austin, B Spolding, S Gondalia, K Shandley, E Palombo, S Knowles, K Walder

(2014), Vol. 21, pp. 236-241, Toxicology International, India, C1-1

journal article
2013

Genetic basis for the increased expression of vacuolar H+ translocating ATPase genes upon imatinib treatment in human lymphoblastoid cells

H Kulkarni, H Goring, J Curran, V Diego, T Dyer, S Cole, K Walder, G Collier, J Blangero, M Carless

(2013), Vol. 71, pp. 1095-1100, Cancer chemotherapy and pharmacology, Heidelberg, Germany, C1

journal article

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

A Walker, S Burnett, K Hasebe, J McGillivray, L Gray, S McGee, K Walder, M Berk, S Tye

(2013), Vol. 242, pp. 76-83, Behavioural brain research, Amsterdam, The Netherlands, C1

journal article

Targeted multimodal liposomes for nano-delivery and imaging: an avenger for drug resistance and cancer.

S Gurudevan, R Kanwar, R Veedu, S Sasidharan, R Kennedy, K Walder, N Prasad, J Kanwar

(2013), Vol. 13, pp. 322-334, Current gene therapy, Bussum, The Netherlands, C1

journal article
2012

The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes

K Bolton, D Segal, K Walder

(2012), Vol. 6, pp. 67-72, Biologics : targets and therapy, Auckland, New Zealand, C1

journal article

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo

N Konstantopoulos, J Molero, S McGee, B Spolding, T Connor, M de Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, V Foletta, G Krippner, S Andrikopoulos, K Walder

(2012), Vol. 61, pp. 2146-2154, Diabetes, Alexandria, Va., C1

journal article

Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines

H Kulkarni, H Goring, V Diego, S Cole, K Walder, G Collier, J Blangero, M Carless

(2012), Vol. 5, pp. 1-12, BMC medical genomics, London, England, C1

journal article

Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass

N Cummings, K Shields, J Curran, K Bozaoglu, J Trevaskis, K Gluschenko, G Cai, A Comuzzie, T Dyer, K Walder, P Zimmet, G Collier, J Blangero, J Jowett

(2012), Vol. 36, pp. 201-206, International journal of obesity, London, England, C1

journal article

Design of a miniature UHF PIFA for DBS implants

M Hosain, A Kouzani, S Tye, K Walder, L Kong

(2012), pp. 485-489, CME 2012 : Proceedings of the 2012 IEEE/ICME International Conference on Complex Medical Engineering, Kobe, Japan, E1

conference
2011

A head mountable deep brain stimulation device for laboratory animals

A Kouzani, S Tye, K Walder, L Kong

(2011), pp. 275-280, Advances in computer, communication, control and automation, Berlin, Germany, B1

book chapter

A gene expression signature for insulin resistance

N Konstantopoulos, V Foletta, D Segal, K Shields, A Sanigorski, K Windmill, C Swinton, T Connor, S Wanyonyi, T Dyer, R Fahey, R Watt, J Curran, J Molero, G Krippner, G Collier, D James, J Blangero, J Jowett, K Walder

(2011), Vol. 43, pp. 110-120, Physiological genomics, Bethesda, Md., C1

journal article

Deficiency in interferon-y results in reduced body weight and better glucose tolerance in mice

N Wong, B Fam, G Cempako, G Steinberg, K Walder, T Kay, J Proietto, S Andrikopoulos

(2011), Vol. 152, pp. 3690-3699, Endocrinology, Chevy Chase, Md., C1

journal article
2010

Effects of rosiglitazone on intramyocellular lipid accumulation in Psammomys obesus

J Molero, S Lee, I Leizerman, A Chajut, A Cooper, K Walder

(2010), Vol. 1802, pp. 235-239, B B A - Molecular Basis of Disease, Amsterdam, The Netherlands, C1

journal article

Genetic variation in PARL influences mitochondrian content

J Curran, J Jowett, L Abraham, L Diepeveen, K Elliott, T Dyer, L Kerr-Bayles, M Johnson, A Comuzzie, E Moses, K Walder, G Collier, J Blangero, A Kissebah

(2010), Vol. 127, pp. 183-190, Human genetics, Heidelberg, Germany, C1

journal article

The characterisation of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome

M Prior, V Foletta, J Jowett, D Segal, M Carless, J Curran, T Dyer, E Moses, A McAinch, N Konstantopoulos, K Bozaoglu, G Collier, D Cameron-Smith, J Blangero, K Walder

(2010), Vol. 59, pp. 1057-1064, Metabolism, Philadelphia, Pa., C1

journal article

Chemerin, a novel adipokine in the regulation of angiogenesis

K Bozaoglu, J Curran, C Stocker, M Zaibi, D Segal, N Konstantopoulos, S Morrison, M Carless, T Dyer, S Cole, H Goring, E Moses, K Walder, M Cawthorne, J Blangero, J Jowett

(2010), Vol. 95, pp. 2476-2485, Journal of clinical endocrinology & metabolism, Chevy Chase, Md., C1

journal article

Regulation of skeletal muscle oxidative capacity and insulin signaling by the Mitochondrial Rhomboid Protease PARL

A Civitarese, P MacLean, S Carling, L Kerr-Bayles, R McMillan, A Pierce, T Becker, C Moro, J Finlayson, N Lefort, C Newgard, L Mandarino, W Cefalu, K Walder, G Collier, M Hulver, S Smith, E Ravussin

(2010), Vol. 11, pp. 412-426, Cell metabolism, Cambridge, Mass., C1

journal article
2009

NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors

V Foletta, M Prior, N Stupka, K Carey, D Segal, S Jones, C Swinton, S Martin, D Cameron-Smith, K Walder

(2009), Vol. 587, pp. 1619-1634, Journal of physiology, Oxford, England, C1

journal article

RTKN2 induces NF-KappaB dependent resistance to intrinsic apoptosis in HEK cells and REgulates BCL-2 genes in human CD4+ lymphocytes

F Collier, A Loving, A Baker, J McLeod, K Walder, M Kirkland

(2009), Vol. 2, pp. 9-23, Journal of cell death, Auckland, New Zealand, C1

journal article

Identification of secreted proteins associated with obesity and type 2 diabetes in Psammomys obesus

K Bolton, D Segal, J McMillan, A Sanigorski, G Collier, K Walder

(2009), Vol. 33, pp. 1-13, International journal of obesity, Hampshire, England, C1

journal article

Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity

H Su, J Gunter, M de Vries, T Connor, S Wanyonyi, F Newell, D Segal, J Molero, O Reizes, J Prins, L Hutley, K Walder, J Whitehead

(2009), Vol. 386, pp. 351-355, Biochemical and biophysical research communications, San Diego, Calif., C1

journal article

Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population

K Bozaoglu, D Segal, K Shields, N Cummings, J Curran, A Comuzzie, M Mahaney, D Rainwater, J VandeBerg, J MacCluer, G Collier, J Blangero, K Walder, J Jowett

(2009), Vol. 94, pp. 3085-3088, The Journal of Clinical Endocrinology & Metabolism, Philadelphia, PA, C1

journal article

Enhanced proliferation of human skeletal muscle precursor cells derived from elderly donors cultured in estimated physiological (5%) oxygen

S Martin, F Collier, M Kirkland, K Walder, N Stupka

(2009), Vol. 61, pp. 93-107, Cytotechnology: international journal of cell culture and biotechnology, Dordrecht, Netherlands, C1

journal article
2008

Decorin is a secreted protein associated with obesity and type 2 diabetes

K Bolton, D Segal, J McMillan, J Jowett, L Heilbronn, K Abberton, P Zimmet, D Chisholm, G Collier, K Walder

(2008), Vol. 32, pp. 1113-1121, International journal of obesity, London, England, C1-1

journal article
2007

Chemerin is a novel adipokine associated with obesity and metabolic syndrome

K Bozaoglu, K Bolton, J McMillan, P Zimmet, J Jowett, G Collier, K Walder, D Segal

(2007), Vol. 148, pp. 4687-4694, Endocrinology, Los Angeles, Calif., C1

journal article

Localization and expression of selenoprotein S in the testis of Psammomys obesus

K Windmill, J Tenne-Brown, R Bayles, J Trevaskis, Y Gao, K Walder

(2007), Vol. 38, pp. 97-101, Journal of molecular histology, Amsterdam, The Netherlands, C1

journal article

SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis

K Kim, Y Gao, K Walder, G Collier, J Skelton, A Kissebah

(2007), Vol. 354, pp. 127-132, Biochemical and biophysical research communications, Orlando, Fla., C1

journal article

Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells

Y Gao, J Pagnon, H Feng, N Konstantopoulos, J Jowett, K Walder

(2007), Vol. 356, pp. 636-641, Biochemical and biophysical research communications, Orlando, Fla., C1

journal article
2006

Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays

K Carey, D Segal, R Klein, A Sanigorski, K Walder, G Collier, D Cameron-Smith

(2006), Vol. 56, pp. 246-255, Pathology international, Carlton South, Vic, C1

journal article

Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells

Y Gao, N Hannan, S Wanyonyi, N Konstantopoulos, J Pagnon, H Feng, J Jowett, K Kim, K Walder, G Collier

(2006), Vol. 33, pp. 246-251, Cytokine, Amsterdam, The Netherlands, C1

journal article

Association of genetic vatiation within UBL5 with phenotypes of metabolic syndrome

K Bozaoglu, J Curran, K Elliott, K Walder, T Dyer, D Rainwater, J Vandenberg, A Comuzzie, G Collier, P Zimmet, J Maccluer, J Jowett, J Blangero

(2006), Vol. 78, pp. 147-159, Human biology, Detroit, Mich., C1

journal article
2005

The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes

K Walder, L Kerr-Bayles, A Civitarese, J Jowett, J Curran, K Elliott, J Trevaskis, N Bishara, P Zimmet, L Mandarino, E Ravussin, J Blangero, A Kissebah, G Collier

(2005), Vol. 48, pp. 459-468, Diabetologia, Berlin , Germany, C1

journal article

Genetic variation in selenoprotein S influences inflammatory response

J Curran, J Jowett, K Elliott, Y Gao, K Gluschenko, W Jianmin, D Azim, G Cai, M Mahaney, A Comuzzie, T Dyer, K Walder, P Zimmet, J MacCluer, G Collier, A Kissebah, J Blangero

(2005), Vol. 37, pp. 1234-1241, Nature genetics, New York, N.Y., C1-1

journal article

Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance

J Trevaskis, K Walder, V Foletta, L Kerr-Bayles, J McMillan, A Cooper

(2005), Vol. 146, pp. 3757-3764, Endocrinology, Philadelphia, Pa., C1-1

journal article

PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

R Southgate, C Bruce, A Carey, G Steinberg, K Walder, R Monks, M Watt, J Hawley, M Birnbaum, M Febbraio

(2005), Vol. 19, pp. 2072-2074, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

journal article
2004

Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2

F Collier, C Gregorio-King, T Gough, C Talbot, K Walder, M Kirkland

(2004), Vol. 324, pp. 1360-1369, Biochemical and biophysical research communications, San Diego, Calif., C1

journal article

Identification of hypothalamic genes implicated in the development of obesity in Psammomys obesus using differential display PCR

J Trevaskis, J McMillan, K Windmill, K Walder, G Collier

(2004), Vol. 137, pp. 65-73, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, Tarrytown, N.Y., C1

journal article

Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein

Y Gao, H Feng, K Walder, K Bolton, T Sunderland, N Bishara, M Quick, L Kantham, G Collier

(2004), Vol. 563, pp. 185-190, FEBS letters, Amsterdam, Netherlands, C1

journal article

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

J Molero, T Jensen, P Withers, M Couzens, H Herzog, C Thien, W Langdon, K Walder, M Murphy, D Bowtell, D James, G Cooney

(2004), Vol. 114, pp. 1326-1333, Journal of clinical investigation, New York, N.Y., C1

journal article

Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes

J Jowett, K Elliott, J Curran, N Hunt, K Walder, G Collier, P Zimmet, J Blangero

(2004), Vol. 53, pp. 2467-2472, Diabetes, Alexandria, Va., C1

journal article
2003

Obesity and diabetes gene discovery approaches

K Walder, D Segal, J Jowett, J Blangero, G Collier

(2003), Vol. 9, pp. 1357-1372, Current pharmaceutical design, Schiphol, Netherlands, C1

journal article

Genetic studies in Psammomys obesus

K Walder, D Segal, J Jowett, J Blangero, P Zimmet, G Collier

(2003), Vol. 9, pp. 275-278, Progress in obesity research, Eastleigh, England, C1

journal article

Transcriptional profiling and gene discovery

G Collier, A De Silva, J Tenne-Brown, A Sanigorski, D Segal, L Kantham, K Walder

(2003), Vol. 9, pp. 36-39, Progress in obesity research, London, England, C1

journal article

Elevation in tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells

Y Gao, K Walder, T Sunderland, L Kantham, H Feng, M Quick, N Bishara, A De Silva, G Augert, J Tenne-Brown, G Collier

(2003), Vol. 52, pp. 929-934, Diabetes, New York, N.Y., C1

journal article

The taq IA and Ser311Cys polymorphisms in the dopamine D2 receptor gene and obesity

A Southon, K Walder, A Sanigorski, P Zimmet, G Nicholson, M Kotowicz, G Collier

(2003), Vol. 16, pp. 72-76, Diabetes, nutrition & metabolism, Milano, Italy, C1

journal article

Beacon interacts with cdc2/cdc28-like kinases

L Kantham, L Kerr-Bayles, N Godde, M Quick, R Webb, T Sunderland, J Bond, K Walder, G Augert, G Collier

(2003), Vol. 304, pp. 125-129, Biochemical and biophysical research communications, New York, N.Y., C1

journal article

ORP3 splice variants and their expression in human tissues and hematopoietic cells

F Collier, C Gregorio-King, J Apostolopoulos, K Walder, M Kirkland

(2003), Vol. 22, pp. 1-9, DNA and cell biology, New Rochelle, N.Y., C1-1

journal article
2002

Which genes are important in the development of type 2 diabetes?

G Collier, K Walder, A De Silva, S Morgan, D Segal, L Kantham, G Augert

(2002), pp. 175-186, Insulin resistance and insulin resistance syndrome, London, England, B1

book chapter

Tanis: a link between type 2 diabetes and inflammation?

K Walder, L Kantham, J McMillan, J Trevaskis, L Kerr, A de Silva, T Sunderland, N Godde, Y Gao, N Bishara, K Windmill, J Tenne-Brown, G Augert, P Zimmet, G Collier

(2002), Vol. 51, pp. 1859-1866, Diabetes, New York, N.Y., C1

journal article

Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes

K Walder, E Ziv, R Kalman, K Whitecross, E Shafrir, P Zimmet, G Collier

(2002), Vol. 26, pp. 605-609, International journal of obesity, London, England, C1

journal article

Calpain 3 gene expression in skeletal muscle is associated with body fat content and measures of insulin resistance

K Walder, J McMillan, N Lapsys, A Kriketos, J Trevaskis, A Civitarese, A Southon, P Zimmet, G Collier

(2002), Vol. 26, pp. 442-449, International journal of obesity, London, England, C1

journal article

New approaches to gene discovery with animal models of obesity and diabetes

G Collier, K Walder, A De Silva, J Tenne-Brown, A Sanigorski, D Segal, L Kantham, G Augert

(2002), Vol. 967, pp. 403-413, Annals of the New York academy of science, New York, N.Y., C1

journal article

A custom-built insulin resistance gene chip

K Walder, D Segal, S Chehab, G Augert, D Cameron-Smith, M Hargreaves, G Collier

(2002), Vol. 967, pp. 274-282, Annals of the New York Academy of Sciences, New York, N.Y., C1

journal article
2001

Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats)

K Walder, J McMillan, S Lee, A Civitarese, P Zimmet, G Collier

(2001), Vol. 25, pp. 1281-1285, International journal of obesity, London, England, C1

journal article

Genetic variation and obesity in Australian women: A prospective study.

A De Silva, K Walder, E Boyko, K Whitecross, G Nicholson, M Kolowitz, J Pasco, G Collier

(2001), Vol. 9, pp. 733-740, Obesity, Silver Spring, Md., C1

journal article

AFLP fingerprinting of the human genome

M Prochazka, K Walder, J Xia

(2001), Vol. 108, pp. 59-65, Human genetics, Berlin, Germany, C1-1

journal article
2000

Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus

A Sanigorski, D Cameron-Smith, P Lewandowski, K Walder, A de Silva, G Morton, G Collier

(2000), Vol. 164, pp. 45-50, Journal of endocrinology, Bristol, England, C1-1

journal article

Beacon: a novel gene involved in the regulation of energy balance

G Collier, J McMillan, K Windmill, K Walder, J Tenne-Brown, A de Silva, J Trevaskis, S Jones, G Morton, S Lee, G Augert, A Civitarese, P Zimmet

(2000), Vol. 49, pp. 1766-1771, Diabetes, Arlington, Va., C1-1

journal article

Leptin and the treatment of obesity

K Walder, A De Silva

(2000), Vol. 51, pp. 66-79, Drug Development Research, Hoboken, N.J., C1-1

journal article
1999

Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM : Psammomys obesus

K Walder, P Lewandowski, G Morton, A Sanigorski, A de Silva, P Zimmet, G Collier

(1999), Vol. 23, pp. 83-89, International journal of obesity, London, England, C1-1

journal article
1998

Dysregulation of leptin in response to fasting in insulin-resistant Psammomys obesus (Israeli sand rats)

K Walder, S Lee, P Zimmet, G Collier

(1998), Vol. 47, pp. 125-128, Metabolism, Amsterdam, The Netherlands, C1-1

journal article

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians

K Walder, R Norman, R Hanson, P Schrauwen, M Neverova, C Jenkinson, J Easlick, C Warden, C Pecqueur, S Raimbault, D Ricquier, M Harper, K Silver, A Shuldiner, G Solanes, B Lowell, W Chung, R Leibel, R Pratley, E Ravussin

(1998), Vol. 7, pp. 1431-1435, Human molecular genetics, London, Eng., C1-1

journal article
1997

Leptin and the development of obesity and diabetes in Psammomys obesus

G Collier, K Walder, P Lewandowski, A Sanigorski, P Zimmet

(1997), Vol. 5, pp. 455-458, Obesity research, Silver Spring, Md., C1-1

journal article

Disproportionate increase of fatty acid binding proteins in the livers of obese diabetic Psammomys obesus

P Lewandowski, D Cameron-Smith, K Moulton, K Walder, A Sanigorski, G Collier

(1997), Vol. 827, pp. 536-540, Annals of the New York academy of sciences, Hoboken, N. J., C1-1

journal article

The effect of dietary energy restriction on body weight gain and the development of noninsulin-dependent diabetes mellitus (NIDDM) in Psammomys obesus

K Walder, C Dascaliuc, P Lewandowski, A Sanigorski, P Zimmet, G Collier

(1997), Vol. 5, pp. 193-200, Obesity research, London, England, C1-1

journal article

Development of obesity and insulin resistance in the Israeli sand rat (Psammomys obesus). Does leptin play a role?

G Collier, A De Silva, A Sanigorski, K Walder, A Yamamoto, P Zimmet

(1997), Vol. 827, pp. 50-63, Annals of the New York Academy of Sciences, Chichester, Eng., C1-1

journal article

Ob (obese) gene expression and leptin levels in Psammomys obesus

K Walder, M Willet, P Zimmet, G Collier

(1997), Vol. 1354, pp. 272-278, Biochimica et biophysica acts, Amsterdam, The Netherlands, C1-1

journal article

Non-insulin dependent diabetes mellitus in Psammomys obesus is independent of changes in tissue fatty acid composition

G Collier, F Collier, A Sanigorski, K Walder, D Cameron-Smith, A Sinclair

(1997), Vol. 32, pp. 317-322, Lipids, Berlin, Germany, C1-1

journal article

Diabetes, obesity and leptin in the Israeli sand rat (Psammomys obesus)

G Collier, K Walder, A De Silva, G Morton, P Zimmet

(1997), Vol. 105, pp. 36-37, Experimental and Clinical Endocrinology and Diabetes, C1-1

journal article
1995

Effect of coingestion of fat and protein with carbohydrate feedings on muscle glycogen storage

L Burke, G Collier, S Beasley, P Davis, P Fricker, P Heeley, K Walder, M Hargreaves

(1995), Vol. 78, pp. 2187-2192, Journal of applied physiology, Bethesda, Md., C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Characterisation of chemerin as a novel adipokine associated with obesity and metabolic syndrome

Prof Ken Walder, Dr Jeremy Jowett

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2008: $22,274
  • 2007: $22,274

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, EmPr Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

ARC_DUAPAI ARC_Deakin University Australian Postgraduate Award Industry, ARC Linkage - Projects Rnd 1

  • 2013: $14,921
  • 2012: $183,043
  • 2011: $159,949
  • 2010: $153,111

Antidiabetic effects of a new secreted protein associated with type 2 diabetes

Prof Ken Walder

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2009: $26,054
  • 2008: $26,054

Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes

Prof Ken Walder, A/Prof Fred Pfeffer, Dr Nicky Konstantopoulos, Dr Guy Krippner

ARC Linkage - Projects Rnd 1

  • 2012: $139,973
  • 2011: $88,130
  • 2010: $86,763

The role of amyloid beta in insulin resistance

Prof Sean Mcgee, Prof Ken Walder, Prof Mark Hargreaves

NHMRC Project Grant

  • 2014: $125,826
  • 2013: $138,472
  • 2012: $136,023

Understanding the role of class IIa histone deacetylases in metabolic disease

Prof Sean Mcgee, Prof Ken Walder

NHMRC Project Grant

  • 2014: $164,086
  • 2013: $161,714
  • 2012: $143,600

Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction

Prof Andy Bennett, A/Prof Shane Raidal, Prof Marcel Klaassen, Prof Kate Buchanan, Prof Ken Walder, Dr Michael Magrath, Dr Yonatan Segal, Prof Martyn Jeggo

ARC Linkage - Projects

  • 2017: $54,016
  • 2016: $105,523
  • 2015: $112,909
  • 2014: $60,397

Gene Expression Signature Technology to Repurpose Drugs for Bipolar Disorder

Prof Ken Walder, Prof Michael Berk, Prof Marion Leboyer, Prof Brian Dean

NHMRC Project Grant

  • 2017: $157,493
  • 2016: $207,762
  • 2015: $117,544

The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

Prof Sean Mcgee, Prof Clinton Bruce, Prof Forest White, Prof Ken Walder

NHMRC Project Grant

  • 2020: $10,462
  • 2019: $187,097
  • 2018: $181,879
  • 2017: $169,227

CREDIT: The CRE for the Development of Innovative Therapies for Psychiatric Disorders

Prof Michael Berk, Prof John McGrath, Prof Patrick McGorry, Prof John McNeil, Prof Gin Malhi, Prof Felice Jacka, A/Prof Susan Cotton, Prof Ken Walder, Prof Olivia Dean, Prof Lana Williams

NHMRC - Centres of Research Excellence

  • 2023: $328,702
  • 2022: $498,725
  • 2021: $563,659
  • 2020: $576,585
  • 2019: $510,344

Using 'omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS

Prof Ken Walder, Prof Michael Berk, Dr Chiara Bortolasci, Prof Sean Mcgee, Prof Clinton Bruce, Dr Wolf Marx

NHMRC Targeted Call for Research into Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Grant Opportunity

  • 2024: $117,955
  • 2023: $281,561
  • 2022: $164,314
  • 2021: $152,361
  • 2020: $25,320

Drug discovery for schizophrenia using patient-derived stem cells

Prof Michael Berk, Dr Alexandre Cristino, Prof Ken Walder, Prof Vicky Avery, Dr James McLure, EM/Prof Alan Mackay-Sim

MRFF (NHMRC) - SCTM Stem Cell Therapies Grant

  • 2024: $16,843
  • 2023: $33,686

Other Public Sector Funding

Global Gene Expression Analysis of 10 rat colon tissue samples

Prof Ken Walder

DPI Grant - Research - Department of Primary Industries - Victoria

  • 2009: $16,666

Tissue distribution of RIPTAC in mice.

Prof Ken Walder

DPI Primary Industries Research Victoria

  • 2010: $18,000

Determination of RIPTAC bioavailability, pharmacokinetics and distribution

Prof Ken Walder, Mr Timothy Connor, Ms Briana Randall

DPI Grant - Research - Department of Primary Industries - Victoria

  • 2011: $12,000

Delivery of MIRNA Using Genetically Modified Influenza Virus

Prof John Stambas, Prof Alister Ward, Prof Ken Walder, Ms Yingju Xia

Victorian International Research Scholarships

  • 2014: $60,000

Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction

Prof Andy Bennett, A/Prof Shane Raidal, Prof Marcel Klaassen, Prof Kate Buchanan, Prof Ken Walder, Dr Michael Magrath, Dr Yonatan Segal, Prof Martyn Jeggo

Victorian Department of Economic Development, Jobs, Transport and Resources, Zoos Victoria

  • 2017: $25,000
  • 2016: $25,000
  • 2015: $30,000

Fluorescent Cell Imager

Prof Ken Walder

NHMRC - Equipment Grant (pre 2017)

  • 2014: $18,900

NHMRC Equipment Grant 2016

Prof Michael Berk, Prof Ken Walder

NHMRC - Equipment Grant (pre 2017)

  • 2016: $17,691

The miRNA-mRNA integration of GenieUs multi-omics aberration platform for amyotrophic lateral sclerosis.

Prof Ken Walder, Ms Thi Thuy Trang Truong

International Education Resilience Fund

  • 2022: $15,000

Industry and Other Funding

Positional Candidate Genes Affecting Metabolic Syndrome

Dr Ahmed Kissebah, Prof Ken Walder

NIH Contract - National Institutes of Health

  • 2008: $83,444
  • 2007: $123,502
  • 2006: $96,944

Anti-inflammatory activity of mussel oil

Prof Ken Walder

McFarlane Marketing Grant - Research

  • 2009: $4,700

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, EmPr Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

Ocean Nutrition Canada Ltd

  • 2012: $70,607
  • 2011: $53,835
  • 2010: $52,910

Novel Therapies for the Treatment of Obesity

Prof Ken Walder

ChemGenex Contract Research

  • 2008: $2,133,334
  • 2007: $2,400,000
  • 2006: $2,420,000

Mechanism of action of VVP808

Prof Ken Walder

Verva Grant - Research - Verva Pharmaceuticals Limited

  • 2010: $17,740
  • 2009: $180,000

Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats

Prof Ken Walder

VHS Grant - Research - VITAL HEALTH SCIENCES PTY LTD

  • 2009: $72,500
  • 2008: $72,500

Discovery and development of novel insulin sensitising compounds for the treatment of Type 2 diabetes

Prof Ken Walder, A/Prof Fred Pfeffer, Dr Nicky Konstantopoulos, Dr Guy Krippner

Verva Pharmaceuticals Ltd

  • 2012: $127,200
  • 2011: $174,725
  • 2010: $146,043

Development of a rat model of acute pancreatitis

Prof Ken Walder

Xenome Grant - Research

  • 2009: $80,000

Expression of Galanin receptors in Mouse, Rat and Human Pancreas

Prof Ken Walder

Xenome Grant - Research

  • 2010: $6,500
  • 2009: $6,500

Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats

Prof Ken Walder

VHS Grant - Research - VITAL HEALTH SCIENCES PTY LTD

  • 2010: $72,500

Effects of amylin and leptin in sand rats

Prof Ken Walder

Amylin Pharmaceuticals

  • 2010: $36,132

Effects of novel insulin formulations on body weight and glucose homeostasis in Psammomy obesus

Prof Ken Walder

VHS Grant - Research - VITAL HEALTH SCIENCES PTY LTD

  • 2010: $17,000

New studies to investigate efficacy and safety of VVP808 (Part A)

Prof Ken Walder, Dr Nicky Konstantopoulos, Mr Scott Lee

Verva Pharmaceuticals Ltd

  • 2011: $90,000

Investigate and characterise VVP808 interacting proteins (Part B)

Prof Ken Walder

Verva Pharmaceuticals Ltd

  • 2013: $8,681
  • 2012: $230,000
  • 2011: $160,000

VVP100X - Research Program: Novel analogues for the treatment of type 2 diabetes

Prof Ken Walder

Verva Pharmaceuticals Ltd

  • 2012: $280,000
  • 2011: $70,000

The genetic basis of mercury sensitivity in pink disease survivors

Prof David Austin, Prof Ken Walder, Ms Shakuntla Gondalia, Kerrie Shandley, A/Prof Enzo Palombo, Dr Simon Knowles, Mr Matthew Garrecht

Coalition for SafeMinds - Research Grants

  • 2014: $9,074
  • 2013: $25,720
  • 2012: $18,389

Effects of novel insulin formulations on glucose homeostasis in streptozotocin-treated diabetic rats

Prof Ken Walder

Jogra Nominees Pty Ltd - The Trustee for THE SM WEST FAMILY TRUST

  • 2014: $6,727
  • 2013: $6,727

Effects of encapsulation on bioavailability and distribution of orally administered milk lipid formulations

Prof Ken Walder

WRS Therapeutics, Jogra Nominees Pty Ltd - The Trustee for THE SM WEST FAMILY TRUST

  • 2017: $15,000
  • 2016: $82,899
  • 2014: $12,633

Beak and Feather Disease Virus in wild avian populations in Australia

Prof Andy Bennett, Dr Mathew Berg, Prof Ken Walder, Ms Johanne (Hanne) Marie Martens

ESA - Holsworth Wildlife Research Endowment - 20 571 098 795

  • 2019: $5,100
  • 2017: $4,800
  • 2016: $5,900

Beak and Feather Disease Virus in wild psittacine populations in Australia

Prof Andy Bennett, Dr Mathew Berg, Prof Ken Walder, Ms Johanne (Hanne) Marie Martens

Ecological Society Australia - Student Research Award

  • 2017: $1,500

Repurposing drugs to treat bipolar depression using stem cell technology

Prof Ken Walder, Dr Chiara Bortolasci, Prof Michael Berk

Milken Institute and Baszucki Brain Research Fund - Bipoloar Disorder Grant

  • 2022: $257,128

Can dietary supplementation with Krill-Oil improve ME/CFS symptoms?

Dr Lee Hamilton, Prof Ken Walder, Dr Giselle Allsopp, A/Prof Chris Shaw, Dr Greg Kowalski, Prof Clinton Bruce, Dr Craig Wright, Dr Rhiannon Snipe

Equity Trustees - The Mason Foundation National Medical Program

  • 2024: $95,000
  • 2023: $90,000
  • 2022: $100,000

Biomarkers of negative symptoms, cognitive impairment and metabolic abnormalities in schizophrenia

Prof Alison Yung, Prof Sean Mcgee, Dr Luba Sominsky, Prof Ken Walder, Prof Julie Pasco, Prof Lana Williams, Dr Steve Moylan, Dr Mohammadreza Mohebbi, Dr Zoe Liu, Mr Marko Milicevic, Mr Wesley Plange

Royal Australian and New Zealand College of Psychiatrists Foundation Catalyst Grants

  • 2022: $4,980

Other Funding Sources

Field-emission gun transmission electron microscope for the research in nanomaterials, metal alloys and biological sciences

Prof Ying (Ian) Chen, Prof Matthew Barnett, Prof Peter Hodgson, Prof Xungai Wang, Dr Takuya Tsuzuki, Dr Cui'E Wen, Dr Alexey Glushenkov, Prof Lingxue Kong, Prof Charles Sorrell, Dr Yuebin Zhang, Prof Vicki Chen, Dr Dominic Phelan, Prof Ken Walder, Dr Germanas Peleckis, A/Prof Simon Moulton, Prof John Beynon, Dr Xiaolin Wang, EmPr David Cahill, Dr Pavel Cizek, Prof Neil Barnett, A/Prof Nicole Stanford, Prof Qipeng Guo

ARC LIEF - Linkage Infrastructure Equipment & Facilities Program

  • 2011: $230,000

NHMRC Equipment Grant 2017 - RTCA iCELLigence instrument

Prof Ken Walder

NHMRC - Equipment Grant - Not R&D income countable (2017-current)

  • 2018: $29,584

Neon Open System Electroporator

Prof Ken Walder, Prof Michael Berk

NHMRC - Equipment Grant - Not R&D income countable (2017-current)

  • 2019: $11,347

NHMRC Equipment Grant 2019 - IMPACT

Prof Ken Walder

NHMRC - Equipment Grant - Not R&D income countable (2017-current)

  • 2020: $20,304

EVOS M7000 image system - Thermo Fisher Scientific

Prof Ken Walder

NHMRC - Equipment Grant - Not R&D income countable (2017-current)

  • 2022: $46,957

Supervisions

Principal Supervisor
2023

Thi Thuy Trang Truong

Thesis entitled: Mechanisms of Action of Drugs Used to Treat Bipolar Disorder and Schizophrenia

Doctor of Philosophy (Medicine), School of Medicine

2018

Srisaiyini Kidnapillai

Thesis entitled: Molecular Mechanisms of Action of Drugs Used to Treat Bipolar Disorder

Doctor of Philosophy (Medicine), School of Medicine

2017

Christopher Kintakas

Thesis entitled: ADAMTS5 expression and function in myoblast fusion and muscle regeneration

Doctor of Philosophy (Medicine), School of Medicine

2015

Sugeetha Ramakrishnan

Thesis entitled: The relationship between milk, mammary adipocytes and ECM in regulating murine mammary gland involution

Doctor of Philosophy (Medicine), School of Medicine

Vengama Naidu Modepalli

Thesis entitled: The Marsupial: A unique model for understanding the regulation of lung development

Doctor of Philosophy (Medicine), School of Medicine

Ashalyn Watt

Thesis entitled: Innate immunity in the breast and the role of the milk peptidome

Doctor of Philosophy (Medicine), School of Medicine

2013

Bradley Hayward

Thesis entitled: A Global Approach to Dissecting Lipid-induced Impairment of Liver Gluconeogenesis

Doctor of Philosophy (Medicine), School of Medicine

2011

Richard Bayles

Thesis entitled: A Genetic and Epigenetic Analysis of the Noradrenaline Transporter

Doctor of Philosophy (Medicine), School of Medicine

2010

Lyndal Jane Bayles

Thesis entitled: Mitochondrial Target Discovery in Diabetic Skeletal Muscle

Doctor of Philosophy (Medicine), School of Medicine

2008

Fiona Collier

Thesis entitled: Rhotekin 2, a Novel GTPase Effector Involved in Resistance to Apoptosis

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Matthew Prior

Thesis entitled: AHI-I and NDRG2 Function in Skeletal Muscle and the Development of Type 2 Diabetes

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Kiymet Bozaoglu

Thesis entitled: Metabolically Important Secreted Proteins in Psammomys obesus

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Kristy Ann Bolton

Thesis entitled: Novel Secreted Proteins Involved in Obesity and Type 2 Diabetes

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2007

Subhadhcha Poonsatha

Thesis entitled: Identification and Characterisation of Novel Compound(s) for the Treatment of Type 2 Diabetes

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Associate Supervisor
2024

Kevin Allan Hunter McEwen

Thesis entitled: The Role of Myocyte Enhancer Factor 2 in Adult Skeletal Muscle Metabolism, Mass, and Exercise Adaptive Responses

Doctor of Philosophy (Medicine), School of Medicine

2023

Bhavisha Patel

Thesis entitled: Developing Targeted Therapy for ¿-cell Dysfunction in Type 2 Diabetes

Doctor of Philosophy (Medicine), School of Medicine

Kanika Mehta

Thesis entitled: A Multipronged Approach to Identify Risk Factors and Biomarkers for Poor Cognition

Doctor of Philosophy (Medicine), School of Medicine

2020

Johanne Marie Martens

Thesis entitled: Ecology of Beak and Feather Disease Virus in wild psittacines

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Helena Stokes

Thesis entitled: Chlamydial Infection in Wild and Domesticated Avian Hosts

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2019

Shauna Seneviratne

Thesis entitled: The effects of Ficolin and the Fibrinogen-like domain on ex vivo hematopoietic stem cell expansion.

Doctor of Philosophy (Biol & Chem), Institute for Frontier Materials

Smithamol Sithara

Thesis entitled: A beta-cell specific global approach for drug identification in Type 2 Diabetes

Doctor of Philosophy (Medicine), School of Medicine

2018

Juliane Czeczor

Thesis entitled: Functional Role of Amyloid b42 in Systemic Glucose Metabolism

Doctor of Philosophy (Medicine), School of Medicine

Kirstie Anne De Jong

Thesis entitled: Characterisation of the Obese and T2D Heart - Protein Kinase D, a Possible Therapeutic Target

Doctor of Philosophy (Medicine), School of Medicine

2017

Kyoko Hasebe

Thesis entitled: Investigating Neurobiological Mechanisms Linking Depression and Inflammation

Doctor of Philosophy (Medicine), School of Medicine

Parminder Kaur Ajji

Thesis entitled: Functional characterization of a novel ribosome inactivating protein from Momordica balsamina

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2016

Rajas Kale

Thesis entitled: Developing Neurostimulation Techniques to Investigate Antidepressant and Mood Modulating Behaviors

Doctor of Philosophy (Engineering), School of Engineering

Aung Kyaw Soe

Thesis entitled: A Modular Design Framework for Lab-On-a-Chips

Doctor of Philosophy (Information Technology), Institute for Intelligent Systems Research and Innovation

Simon Bond

Thesis entitled: The Role of Glyceraldehyde-3-Phosphate Dehydrogenase Acetylation in Liver Metabolism

Doctor of Philosophy (Medicine), School of Medicine

2015

Daniel Fraher

Thesis entitled: Chemical Modulators of Lipid Abundance and Bone Development

Doctor of Philosophy (Medicine), School of Medicine

Anand Khedkar

Thesis entitled: Development and Evaluation of a Novel Insulin Analogue

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Rajneesh Chaudhary

Thesis entitled: Zinc doped ferrite magnetic resonance imaging contrast agent for atherosclerosis

Doctor of Philosophy (Medicine), School of Medicine

Justin Eastwood

Thesis entitled: The Ecology and Evolution of Beak and Feather Disease Virus in Platycercus elegans

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2014

Vidhi Gaur

Thesis entitled: HDAC inhibition as a therapeutic potential to treat metabolic diseases

Doctor of Philosophy (Medicine), School of Medicine

2013

Bingshan Li

Thesis entitled: Production and Characterisation of Powdered Fibrous Materials

Doctor of Philosophy (Engineering), Institute for Frontier Materials

2004

James Trevaskis

Thesis entitled: Novel Hypothalamic Genes Involved in Body Weight Regulation in Psammomys obesus

Doctor of Philosophy, School of Exercise and Nutrition Sciences

2002

Anthony Civitarese

Thesis entitled: Novel Genes in the Muscle of Obese-Diabetic Psammomys obesus

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Health Sciences

Adam Southon

Thesis entitled: Novel Genes in the Liver of Diabetic Psammomys obesus

Master of Science, School of Health Sciences