Prof Leigh Ackland

STAFF PROFILE

Position

Personal Chair

Faculty

Faculty of Sci Eng & Built Env

Department

School of Life & Env. Sciences

Campus

Melbourne Burwood Campus

Qualifications

Bachelor of Science, University of Melbourne, 1973
Master of Science, University of Melbourne, 1976
Doctor of Philosophy, University of Melbourne, 1993

Contact

leigh.ackland@deakin.edu.au
+61 3 925 17036

Career highlights

In 2014 I was one of 26 international leading scientists invited to participate in the Ernst Strungman forum on Heavy Metals and Infectious Diseases, to address key gaps in knowledge in global issues, held in Frankfurt, Germany.

Research interests

Molecular biology of trace elements in human diseases
My team and I have applied molecular genetic techniques, protein chemistry and confocal microscopy to understand how zinc and copper get into and out of cells. We developed expertise in the manipulation of human cells in culture to mimic human tissues including the mammary gland, skin, gut and placenta. We have studied inherited disorders in humans that result in the production of trace element-deficient milk during lactation.

Epigenetic Factors in Gestational Diabetes

Mechanisms underlying the spread of breast cancer cells
Using a novel human breast cancer line we study the mechanisms of breast cancer metastasis termed “epithelial to mesenchymal transition”.

Role of omega-3 fatty acids in brain disorders
In cultured human neuronal cells we recently found that the omega-3 fatty acid, DHA, prevents cells from dying through a zinc signalling mechanism. This has implications for use of DHA in preventing or treating degenerative brain disorders.

Nanolipids and brain cell survival
We are investigating the use of nanotechnology for delivering omega-3 fatty acids to the brain.

Development of remediation strategies for heavy metal-contaminated soils and water
Field trials of selected plants to remediate cadmium-contaminated soils are underway and the cellular mechanisms that enable plants to accumulate or resist heavy metals are being investigated.

Teaching interests

Introducing an understanding of the experimental basis of science and how research has shaped our understanding of biology

Expertise

Biology of metals and metal transporters in prokaryote and eukaryote cells. Epithelial to mesenchymal transition in cancer progression.

Projects

Molecular biology of zinc and copper in human diseases
My team and I have applied molecular genetic techniques, protein chemistry and confocal microscopy to understand zinc and copper fluxes in cells. We developed expertise in the manipulation of human cells in culture to mimic human tissues including the mammary gland, skin, gut and placenta. We have studied inherited disorders in humans that result in the production of trace element-deficient milk during lactation.

Mechanisms underlying the spread of breast cancer cells
Using a novel human breast cancer line we study the mechanisms of breast cancer metastasis termed “epithelial to mesenchymal transition”.

Role of omega-3 fatty acids in brain disorders
In cultured human neuronal cells we recently found that the omega-3 fatty acid, DHA, prevents cells from dying through a zinc signalling mechanism. This has implications for use of DHA in preventing or treating degenerative brain disorders.

Nanolipids and brain cell survival
We are investigating the use of nanotechnology for delivering omega-3 fatty acids to the brain.

Development of remediation strategies for heavy metal-contaminated soils and water
Field trials of selected plants to remediate cadmium-contaminated soils are underway and the cellular mechanisms that enable plants to accumulate or resist heavy metals are being investigated.

Epigenetic Factors in diabetesWith a team of clinicians, we are investigating changers in histone methylation that occur in diabetes during pregnancy.

Publications

Filter by

2017

Peroxide reduction by a metal-dependent catalase in Nostoc punctiforme (cyanobacteria)

Dr Lee Hudek, Dr Angel Torriero, Dr Agnes Michalczyk, B. A. Neilan, Prof Leigh Ackland, Dr Lambert Brau

(2017), Vol. 101, pp. 3781-3800, Applied microbiology and biotechnology, Berlin, Germany, C1

journal
2016

Identification and topographical characterisation of microbial nanowires in Nostoc punctiforme

Sandeep Sure, Dr Angel Torriero, Aditya Gaur, Dr Luhua Li, Prof Ying (Ian) Chen, Chandrakant Tripathi, Dr Alok Adholeya, Prof Leigh Ackland, Dr Mandira Kochar

(2016), Vol. 109, pp. 475-480, Antonie Van Leeuwenhoek, Cham, Switzerland, C1

journal

Epigenetic markers to predict conversion from gestational diabetes to type 2 diabetes

Dr Agnes Michalczyk, Prof James Dunbar, Prof Edward Janus, Prof James Best, Peter Ebeling, Michael J. Ackland, Mr Dino Asproloupos, Prof Leigh Ackland

(2016), Vol. 101, pp. 2396-2404, Journal of clinical endocrinology and metabolism, Washington D.C., United States, C1

journal

Ceruloplasmin is regulated by copper and lactational hormones in PMC42-LA mammary epithelial cell culture models

Dr David Freestone, Dr Delphine Denoyer, Mr MATTHEW JAKAB, Prof Leigh Ackland, Dr Michael Cater, Dr Agnes Michalczyk

(2016), Vol. 8, pp. 941-950, Metallomics, Cambridge, Eng., C1

journal

Probing synechocystis-arsenic interactions through extracellular nanowires.

Mr Sandeep Karbhari Sure, Prof Leigh Ackland, Aditya Gaur, Priyanka Gupta, Dr Alok Adholeya, Dr Mandira Kochar

(2016), Vol. 7, pp. 1-12, Frontiers in microbiology, Lausanne, Switzerland, C1

journal

Zinc and infant nutrition

Prof Leigh Ackland, Dr Agnes Michalczyk

(2016), Vol. 611, pp. 51-57, Archives of biochemistry and biophysics, Amsterdam, The Netherlands, C1

journal

Real-time quartz crystal microbalance monitoring of free docosahexaenoic acid interactions with supported lipid bilayers.

Miss Kiera Flynn, Lisandra L. Martin, Prof Leigh Ackland, Dr Angel Torriero

(2016), Vol. 32, pp. 11717-11727, Langmuir, Washington D.C., Wash., C1

journal

Microbial nanowires : an electrifying tale

Mr Sandeep Karbhari Sure, Prof Leigh Ackland, Dr Angel Torriero, Dr Alok Adholeya, Dr Mandira Kochar

(2016), Vol. 162, pp. 2017-2028, Microbiology, London, Eng., C1

journal
2015

Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol

Dr Wren Greene, Lisandra L. Martin, Rico Tabor, Dr Agnes Michalczyk, Prof Leigh Ackland, Prof Roger Horn

(2015), Vol. 53, pp. 127-136, Biomaterials, Amsterdam, The Netherlands, C1

journal

Inquisition of Microcystis aeruginosa and Synechocystis nanowires: characterization and modelling

Sandeep Sure, Dr Angel Torriero, Aditya Gaur, Dr Luhua Li, Prof Ying (Ian) Chen, Chandrakant Tripathi, Alok Adholeya, Prof Leigh Ackland, Mandira Kochar

(2015), Vol. 108, pp. 1213-1225, Antonie van Leeuwenhoek: international journal of general and molecular microbiology, New York, N.Y., C1

journal

The ZntA-like NpunR4017 plays a key role in maintaining homeostatic levels of zinc in Nostoc punctiforme

Dr Lee Hudek, Dr Lambert Brau, Dr Agnes Michalczyk, B. A. Neilan, J Meeks, Prof Leigh Ackland

(2015), Vol. 99, pp. 10559-10574, Applied microbiology and biotechnology, New York, N.Y., C1

journal

Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk

Mrs Loveleen Kumar, Dr Agnes Michalczyk, Jill McKay, Diane Ford, Taiho Kambe, Dr Lee Hudek, George Varigios, Dr Philip Taylor, Prof Leigh Ackland

(2015), Vol. 10, pp. 487-502, Genes and nutrition, New York, N.Y., C1

journal

Characterization of two cation diffusion facilitators NpunF0707 and NpunF1794 in Nostoc punctiforme

Dr Lee Hudek, L A Pearson, Dr Agnes Michalczyk, Dr Lambert Brau, Brett A Neilan, Prof Leigh Ackland

(2015), Vol. 119, pp. 1357-1370, Journal of applied microbiology, Weinheim, Germany, C1

journal

Metals in the environment as risk factors for infectious diseases: gaps and opportunities

Prof Leigh Ackland, Julia Bornhorst, George Dedoussis, Rodney Dietert, Jerome Nriagu, Jozef Pacyna, John Pettifor

(2015), pp. 270-307, Trace metals and infectious diseases, Cambridge, Mass., B1

chapter
2014

Zinc and zinc transporters in macrophages and their roles in efferocytosis in COPD

Rhys Hamon, Claire Homan, Hai B Tran, Dr Violet Mukaro, Susan Lester, Eugene Roscioli, Mariea Bosco, Chiara Murgia, Prof Leigh Ackland, Hubertus Jersmann, Carol J. Lang, Dr Peter Zalewski, Sandra Hodge

(2014), Vol. 9, pp. 1-9, PLoS one, San Francisco, CA, C1

journal

Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models

Dr David Freestone, Dr Michael Cater, Prof Leigh Ackland, David Paterson, Daryl Howard, Martin de Jonge, Dr Agnes Michalczyk

(2014), Vol. 25, pp. 377-387, Journal of Nutritional Biochemistry, New York, NY, C1

journal

Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures

Miss Dwan Price, Prof Leigh Ackland, Wesley Burks, Matthew Knight, A/Prof Cenk Suphioglu

(2014), Vol. 33, pp. 1758-1777, Cellular Physiology and Biochemistry, Basel, Switzerland, C1

journal

Comparative analyses of cadmium and zinc uptake correlated with changes in natural resistance-associated macrophage protein (NRAMP) expression in Solanum nigrum L. and Brassica rapa

Prof Yufang Song, Dr Lee Hudek, Dr David Freestone, Puhui Ji, Dr Agnes Michalczyk, Z Senlin, Prof Leigh Ackland

(2014), Vol. 11, pp. 653-660, Environmental chemistry, Clayton, Vic., C1

journal
2013

Composition, sources, and potential toxicology of polycyclic aromatic hydrocarbons (PAHs) in agricultural soils in Liaoning, People’s Republic of China

Xiufeng Cao, Maio Liu, Prof Yufang Song, Prof Leigh Ackland

(2013), Vol. 185, pp. 2231-2241, Environmental monitoring and assessment, Dordrecht, Netherlands, C1

journal

A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)

Christer Hogstrand, Peter Kille, Prof Leigh Ackland, Stephen Hiscox, Dr Kathryn Taylor

(2013), Vol. 455, pp. 229-237, Biochemical journal, London, England, C1

journal

hZip1 (hSLC39A1) regulates zinc homoeostasis in gut epithelial cells

Dr Agnes Michalczyk, Prof Leigh Ackland

(2013), Vol. 8, pp. 475-486, Genes and nutrition, Berlin, Germany, C1

journal

Molecular and cellular characterisation of the zinc uptake (Znu) system of Nostoc punctiforme

Dr Lee Hudek, L A Pearson, Dr Agnes Michalczyk, B. A. Neilan, Prof Leigh Ackland

(2013), Vol. 86, pp. 149-171, FEMS microbiology ecology, Oxford, England, C1

journal

Functional characterization of the twin ZIP/SLC39 metal transporters, NpunF3111 and NpunF2202 in Nostoc punctiforme

Dr Lee Hudek, L A Pearson, Dr Agnes Michalczyk, B. A. Neilan, Prof Leigh Ackland

(2013), Vol. 97, pp. 8649-8662, Applied microbiology and biotechnology, Berlin, Germany, C1

journal

Zinc homeostasis in cyanobacteria

Dr Lee Hudek, Dr Agnes Michalczyk, Brett A Neilan, Prof Leigh Ackland

(2013), pp. 245-256, Stress biology of cyanobacteria : molecular mechanisms to cellular responses, Boca Raton, Flo., B1-1

chapter

Nuts 'n' guts: transport of food allergens across the intestinal epithelium

Miss Dwan Price, Prof Leigh Ackland, A/Prof Cenk Suphioglu

(2013), Vol. 3, pp. 257-265, Asia Pacific allergy, Seoul, Korea, C1-1

journal
2012

Effects of zinc and DHA on the epigenetic regulation of human neuronal cells

Ms Nadia Christella Sadli, Prof Leigh Ackland, Mr Vidanelage Damitha De Mel, Prof Andrew Sinclair, A/Prof Cenk Suphioglu

(2012), Vol. 29, pp. 87-98, Cellular physiology and biochemistry, Basel, Switzerland, C1

journal

Copper levels in buccal cells of vineyard workers engaged in various activities

Tim Thompson, Dr David Freestone, Dr Agnes Michalczyk, Prof Leigh Ackland

(2012), Vol. 56, pp. 305-314, Annals of occupational hygiene, Oxford, England, C1

journal

Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice

Yu-Ling Chu, Eric N. Sauble, Anthony Cabrera, Aleeza Roth, Prof Leigh Ackland, Prof Julian Mercer, Prof Maria C Linder

(2012), Vol. 25, pp. 373-382, BioMetals, Dordrecht, The Netherlands, C1

journal

Physiological metal uptake by Nostoc punctiforme

Dr Lee Hudek, S. Rai, Dr Agnes Michalczyk, Prof L C Rai, B. A. Neilan, Prof Leigh Ackland

(2012), Vol. 25, pp. 893-903, BioMetals, Dordrecht, The Netherlands, C1

journal

Biochemical responses of earthworm Eisenia fetida exposed to cadmium-contaminated soil with long duration

Xiao-Xia Yang, Prof Yufang Song, Prof Leigh Ackland, Yang Liu, Xiufeng Cao

(2012), Vol. 89, pp. 1148-1153, Bulletin of environmental contamination and toxicology, New York, N. Y., C1

journal

Contribution of fibroblast and mast cell (afferent) and tumor (efferent) IL-6 effects within the tumor microenvironment

Honor J Hugo, Stephanie C Lebret, Eva Tomaskovic-Crook, Dr Nuzhat Ahmed, Tony Blick, Donald Newgreen, A/Prof Erik Thompson, Prof Leigh Ackland

(2012), Vol. 5, pp. 83-93, Cancer microenvironment, Dordrecht, The Netherlands, C1

journal
2011

Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway

Ayako Fukunaka, Yayoi Kurokawa, Fumie Teranishi, Israel Sekler, Kimimitsu Oda, Prof Leigh Ackland, Victor Faundez, Makoto Hiromura, Seiji Masuda, Masaya Nagao, Shuichi Enomoto, Taiho Kambe

(2011), Vol. 286, pp. 16363-16373, Journal of biological chemistry, Bethesda, Md., C1

journal

Dietary zinc mediates inflammation and protects against wasting and metabolic derangement caused by sustained cigarette smoke exposure in mice

Carol J. Lang, Michelle Hansen, Eugene Roscioli, Jessica Jones, Chiara Murgia, Prof Leigh Ackland, Dr Peter Zalewski, Gary Anderson, Richard Ruffin

(2011), Vol. 24, pp. 23-39, BioMetals, Dordrecht, Netherlands, C1

journal

Defining the E-Cadherin repressor interactome in epithelial-mesenchymal transition : the PMC42 model as a case study

Honor J Hugo, Maria I. Kokkinos, Tony Blick, Prof Leigh Ackland, A/Prof Erik Thompson, Donald Newgreen

(2011), Vol. 193, pp. 23-40, Cells, tissues, organs : in vivo, in vitro, Basel, Switzerland, C1

journal

Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta

Ms Belinda Mary Hardman, S. Luff, Prof Leigh Ackland

(2011), Vol. 32, pp. 79-85, Placenta, Oxford, England, C1

journal

Strategies for enhancing the phytoremediation of cadmium-contaminated agricultural soils by Solanum nigrum L

Puhui Ji, Tie-heng Sun, Prof Yufang Song, Prof Leigh Ackland, Yang Liu

(2011), Vol. 159, pp. 762-768, Environmental pollution, Oxford, England, C1

journal

Effect of zinc and DHA on expression levels and post-translational modifications of histones H3 and H4 in human neuronal cells

Ms Nadia Christella Sadli, Mr Nayyar Ahmed, Prof Leigh Ackland, Prof Andrew Sinclair, Prof Colin Barrow, A/Prof Cenk Suphioglu

(2011), pp. 141-164, Neurodegenerative diseases - processes, prevention, protection and monitoring, Rijecka, Croatia, B1

chapter

Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation

Chiara Murgia, Dion Grosser, Ai Q. Truong-Tran, Eugene Roscioli, Dr Agnes Michalczyk, Prof Leigh Ackland, Meredin Stoltenberg, Gorm Danscher, Carol J. Lang, Darryl Knight, Giuditta Perozzi, Richard Ruffin, Dr Peter Zalewski

(2011), Vol. 3, pp. 910-928, Nutrients, Basel, Switzerland, C1

journal
2010

Assessing health risk of reclaimed water using human cell culture.

Prof Leigh Ackland, Dr Agnes Michalczyk, Dr David Freestone, Prof Frank Stagnitti

(2010), Vol. 37, pp. 39-43, Water, St Leonards, N.S.W., C1

journal

Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B : emerging roles

Dr Sharon La Fontaine, Prof Leigh Ackland, Prof Julian Mercer

(2010), Vol. 42, pp. 206-209, International journal of biochemistry & cell biology, Oxford, England, C1

journal

Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells

A/Prof Cenk Suphioglu, Ms Nadia Christella Sadli, Mr Damon Coonan, Mrs Loveleen Kumar, Mr Vidanelage Damitha De Mel, Jessica Lesheim, Prof Andrew Sinclair, Prof Leigh Ackland

(2010), Vol. 103, pp. 344-351, British journal of nutrition, Cambridge, England, C1

journal

The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport

A/Prof Cenk Suphioglu, Mr Vidanelage Damitha De Mel, Mrs Loveleen Kumar, Ms Nadia Christella Sadli, Dr David Freestone, Dr Agnes Michalczyk, Prof Andrew Sinclair, Prof Leigh Ackland

(2010), Vol. 584, pp. 612-618, FEBS letters, Amsterdam, The Netherlands, C1

journal
2009

植物CytP450和抗氧化酶对土壤菲、芘暴露的生态毒理响应

Prof Yufang Song, Lei Wang, Xinxin Li, Dr Wei Zhang, Lang Chen, Dr David Freestone, Puhui Ji, Prof Leigh Ackland

(2009), Vol. 29, pp. 381-388, Acta scientiae circumstantiae, Beijing, China, C1

journal

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

Michelle Colomiere, Prof Alister Ward, Clyde Riley, Dr Marissa Caldow, A/Prof David Cameron-Smith, Jock Findlay, Prof Leigh Ackland, Dr Nuzhat Ahmed

(2009), Vol. 100, pp. 134-144, British journal of cancer, London, England, C1

journal

Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of α6β1 integrin

Michelle Colomiere, Jock Findlay, Prof Leigh Ackland, Dr Nuzhat Ahmed

(2009), Vol. 41, pp. 1034-1045, The international journal of biochemistry and cell biology, Oxford, England, C1

journal

Bioinformatic and expression analyses of genes mediating zinc homeostasis in Nostoc punctiforme

Dr Lee Hudek, Prof L C Rai, Dr David Freestone, Dr Agnes Michalczyk, Dr Maria Gibson, Prof Yufang Song, Prof Leigh Ackland

(2009), Vol. 75, pp. 784-791, Applied and environmental microbiology, Washington, D.C., C1

journal

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Miss Kristy Shield, Prof Leigh Ackland, Dr Nuzhat Ahmed, Gregory E. Rice

(2009), Vol. 113, pp. 143-148, Gynecologic oncology, San Diego, Calif., C1

journal

植物CytP450和抗氧化酶对土壤低浓度菲、芘胁迫的响应

Prof Yufang Song, Xinxin Li, Dr Wei Zhang, Dr David Freestone, Prof Leigh Ackland, Lang Chen, Puhui Ji, Xiao-Xia Yang

(2009), Vol. 29, pp. 3768-3774, Acta ecologica sinica, Beijing, China, C1-1

journal

Pulse-lavage brushing followed by hydrogen peroxide-gauze packing for bone-bed preparation in cemented total hip arthroplasty : a bovine model

David C. Ackland, Vincent Yap, Prof Leigh Ackland, John F. Williams, Mr Richard de Steiger

(2009), Vol. 17, pp. 296-300, Journal of orthopaedic surgery, Hong Kong, C1-1

journal

Nutritional and functional status indicators in residents of a long-term care facility

Dr Jessica Grieger, Prof Caryl Nowson, Prof Leigh Ackland

(2009), Vol. 28, pp. 47-60, Journal of nutrition for the elderly, New York, N.Y., C1

journal

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Dr Jessica Grieger, Prof Caryl Nowson, A/Prof Heather Jarman, Rob Malon, Prof Leigh Ackland

(2009), Vol. 63, pp. 558-565, European journal of clinical nutrition, Basingstoke, England, C1

journal
2008

Copper is taken up efficiently from albumin and α2-macroglobulin by cultured human cells by more than one mechanism

Mizue Moriya, Yi-Hsuan Ho, Anne Grana, Linh Nguyen, Arrissa Alvarez, Rita Jamil, Prof Leigh Ackland, Dr Agnes Michalczyk, Pia Hamer, Danny Ramos, Stephen Kim, Prof Julian Mercer, Prof Maria C Linder

(2008), Vol. 295, pp. 708-721, American journal of physiology: cell physiology, Bethesda, Md., C1

journal

主在并[a] 龍財赤子愛腔蚓錢粒体編研基因衰退影蝸

Senlin Zheng, Prof Yufang Song, Xiao-yan Qiu, Tie-heng Sun, Dr Wei Zhang, Prof Leigh Ackland

(2008), Vol. 29, pp. 391-397, Chinese journal of environmental science, Beijing, China, C1

journal

Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9

Silke Overbeck, Peter Uciechowski, Prof Leigh Ackland, Dianne Ford, Lothar Rink

(2008), Vol. 83, pp. 368-380, Journal of leukocyte biology, Bethesda, Md., C1

journal

Annetocin and TCTP expressions in the earthworm Eisenia fetida exposed to PAHs in artificial soil

Senlin Zheng, Prof Yufang Song, Xiaoyan Qui, Tie-heng Sun, Prof Leigh Ackland, Dr Wei Zhang

(2008), Vol. 71, pp. 566-573, Ecotoxicology and environmental safety, Maryland Heights, Mo., C1

journal

ATP7B expression in human breast epithelial cells is mediated by lactational hormones

Dr Agnes Michalczyk, Edward Bastow, Mark Greenough, Prof James Camakaris, Dr David Freestone, Dr Philip Taylor, Prof Maria C Linder, Prof Julian Mercer, Prof Leigh Ackland

(2008), Vol. 56, pp. 389-399, Journal of histochemistry and cytochemistry, Seattle, Wash., C1

journal

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

Dr Roxana Llanos, Dr Agnes Michalczyk, Dr David Freestone, Scott Alan Currie, Prof Maria C Linder, Prof Leigh Ackland, Prof Julian Mercer

(2008), Vol. 372, pp. 613-617, Biochemical and biophysical research communications, San Diego, Calif., C1

journal
2007

α2β1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis

Miss Kristy Shield, Clyde Riley, Michael A. Quinn, Gregory E. Rice, Prof Leigh Ackland, Dr Nuzhat Ahmed

(2007), Vol. 6, pp. 1-15, Journal of carcinogenesis, London, England, C1

journal

Genotoxicity assessment of soils from wastewater irrigation areas and bioremediation sites using the Vicia faba root tip micronucleus assay

Prof Yufang Song, P. Gong, B.M. Wilke, Dr Wei Zhang, X.Y. Song, Tie-heng Sun, Prof Leigh Ackland

(2007), Vol. 9, pp. 182-186, Journal of environmental monitoring, London, England, C1

journal

Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors

Stephanie C Lebret, Donald Newgreen, A/Prof Erik Thompson, Prof Leigh Ackland

(2007), Vol. 9, pp. 1-15, Breast cancer research, London, England, C1

journal

Diesel exhaust particulate matter induces multinucleate cells and zinc transporter-dependent apoptosis in human airway cells

Prof Leigh Ackland, A/Prof Linda Zou, Dr David Freestone, S van de Waasenburg, Dr Agnes Michalczyk

(2007), Vol. 85, pp. 617-622, Immunology and cell biology, London, England, C1

journal

Epithelial - mesenchymal and mesenchymal - epithelial transitions in carcinoma progression

Honor J Hugo, Prof Leigh Ackland, Tony Blick, Mitchell G. Lawrence, Judith A. Clements, Dr Elizabeth D Williams, A/Prof Erik Thompson

(2007), Vol. 213, pp. 374-383, Journal of cellular physiology, New York, N.Y., C1

journal

Distinct functional roles for the Menkes and Wilson copper translocating P-type ATPases in Human Placental Cells

Ms Belinda Mary Hardman, Dr Agnes Michalczyk, Mark Greenough, Prof James Camakaris, Prof Julian Mercer, Prof Leigh Ackland

(2007), Vol. 20, pp. 1073-1084, Cellular physiology and biochemistry, Basel, Switzerland, C1

journal

Anthropometric and biochemical markers for nutritional risk among residents within an Australian residential care facility

Dr Jessica Grieger, Prof Caryl Nowson, Prof Leigh Ackland

(2007), Vol. 16, pp. 178-186, Asia Pacific journal of clinical nutrition, Melbourne, Vic., C1

journal

Effects of low dosage pyrene pollution on biochemical characters of earthworm (Eisenia fetida) in soil

Dr Wei Zhang, Prof Yufang Song, Tie-heng Sun, Maio Liu, Prof Leigh Ackland, Galina Belogolova

(2007), Vol. 18, pp. 2097-2103, Chinese journal of applied ecology, China, C1

journal

Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells

Ms Belinda Mary Hardman, Dr Agnes Michalczyk, Mark Greenough, Prof James Camakaris, Prof Julian Mercer, Prof Leigh Ackland

(2007), Vol. 402, pp. 241-250, Biochemical journal, London, England, C1

journal
2006

Zinc deficiency and its inherited disorders - A review

Prof Leigh Ackland, Dr Agnes Michalczyk

(2006), Vol. 1, pp. 41-50, Genes & nutrition, New Orleans, LA, C1

journal

Apoptosis may underlie the pathology of zinc-deficient skin

Dallas Wilson, Dr George Varigos, Prof Leigh Ackland

(2006), Vol. 84, pp. 28-37, Immunology and cell biology, Adelaide, S.Aust., C1

journal

Myoepithelial molecular markers in human breast carcinoma PMC42-LA cells are induced by extracellular matrix and stromal cells

Stephanie C Lebret, Donald Newgreen, Mark Waltham, John Price, A/Prof Erik Thompson, Prof Leigh Ackland

(2006), Vol. 42, pp. 298-307, In vitro cellular & developmental biology - animal, New York, N. Y., C1

journal

Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells

Ms Belinda Mary Hardman, U Manuelpillai, E Wallace, Mr Francois Monty, Dr David Kramer, Y.M. Kuo, Prof Julian Mercer, Prof Leigh Ackland

(2006), Vol. 27, pp. 968-977, Placenta, London, England, C1

journal
2005

Synergistic antiproliferative action of the Flavonols Quercetin and Kaempferol in cultured human cancer cell lines

Prof Leigh Ackland, S van de Waasenburg, Rod Jones

(2005), Vol. 19, pp. 69-76, In Vivo: international journal of experimental and clinical pathophysiology and drug research, Athens, Greece, C1

journal

Perinatal ω-3 polyunsaturated fatty acid supply modifies brain zinc homeostasis during adulthood

Anura. P. Jayasooriya, Prof Leigh Ackland, Michael. L Mathai, Prof Andrew Sinclair, Dr Harry Weisinger, Richard. S. Weisinger, John. E. Halver, Klara Kitajka, Laszlo Puskas

(2005), Vol. 102, pp. 7133-7138, Proceedings of the National Academy of Sciences, Washington, D.C., C1

journal
2004

Fresh and cultured buccal cells as a source of mRNA and protein for molecular analysis

Dr Agnes Michalczyk, Dr George Varigos, Lance Smith, Prof Leigh Ackland

(2004), Vol. 37, pp. 2-7, Biotechniques, Natick, Mass., C1

journal

Expression and localization of Menkes and Wilson copper transporting ATPases in human placenta

Ms Belinda Mary Hardman, U Manuelpillai, E Wallace, S van de Waasenburg, Dr Michael Cater, Prof Julian Mercer, Prof Leigh Ackland

(2004), Vol. 25, pp. 512-517, Placenta, Amsterdam, Netherlands, C1

journal
2003

Extracellular matrix induces formation of organoids and changes in cell surface morphology in cultured human breast carcinoma cells PMC42-LA

Prof Leigh Ackland, John Ward, Christopher Ackland, Mark Greaves, Mary Walker

(2003), Vol. 39, pp. 428-433, In vitro cellular and development biology - animal, Raleigh, N.C., C1-1

journal

Analysis of zinc transporter, hZnT4(Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk

Dr Agnes Michalczyk, Dr George Varigos, Anthony Catto-Smith, Rachael Blomeley, Prof Leigh Ackland

(2003), Vol. 113, pp. 202-210, Human genetics, Berlin, Germany, C1

journal

Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells

Prof Leigh Ackland, Donald Newgreen, Dr Masha Fridman, Mark Waltham, Angela Arvanitis, Joseph Minichiello, John Price, A/Prof Erik Thompson

(2003), Vol. 83, pp. 435-448, Laboratory investigation, Baltimore, Md., C1

journal
2002

Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells

Dr Agnes Michalczyk, Justin Allen, Rachael Blomeley, Prof Leigh Ackland

(2002), Vol. 364, pp. 105-113, Biochemical journal, London, England, C1

journal
2001

PMC42, a novel model for the differentiated human breast

Prof Leigh Ackland, Dr Agnes Michalczyk, Dr Robert Whitehead

(2001), Vol. 263, pp. 14-22, Experimental cell research, St. Louis, Mo., C1

journal

Creatine transporter protein content, localization, and gene expression in rat skeletal muscle

Robyn M. Murphy, G McConell, A/Prof David Cameron-Smith, Mr Kenneth Watt, Prof Leigh Ackland, B Walzel, T Wallimann, Prof Rod Snow

(2001), Vol. 280, pp. C415-C422, American journal of physiology. Cell physiology, Bethesda, Md., C1

journal

Grants

Australian Competitive Grants

Molecular Eco-toxicology for diagnosis of priority pollutants in soil

Prof Leigh Ackland, Prof Yufang Song

DEST/ISL Grant - Australian-China Special Fund for Science and Tech Cooperation - Department of Education, Science and Technology - International Science Linkages

  • 2010: $7,000
  • 2007: $23,000

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, Prof Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

ARC Linkage - Projects Rnd 1, ARC_DUAPAI ARC_Deakin University Australian Postgraduate Award Industry

  • 2013: $14,921
  • 2012: $183,043
  • 2011: $159,949
  • 2010: $153,111

Triggering the dormant capacity of fish to make omega 3 fatty acids

Prof Giovanni Turchini, Prof Andrew Sinclair, Prof Leigh Ackland

ARC - Discovery Projects

  • 2014: $57,969
  • 2013: $56,269
  • 2012: $86,138
  • 2011: $82,946
  • 2010: $81,660

The contribution of host caveolin-1 to breast cancer metastasis

A/Prof Robin Anderson, Prof Leigh Ackland

NHMRC Project Grant

  • 2012: $55,000
  • 2011: $55,000
  • 2010: $55,000

Nanoliposomal delivery of DHA to neuronal cells

Prof Leigh Ackland, Prof Andrew Sinclair, A/Prof Cenk Suphioglu, Prof Harjinder Singh

ARC - Discovery Projects

  • 2014: $99,992
  • 2013: $97,059
  • 2012: $103,848

NABNEC: A Randomised Phase II Study Of Nab-paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas

Dr Mustafa Khasraw, A/Prof lara Lipton, Dr Lorraine Chantrill, A/Prof Michael Hofman, Prof Leigh Ackland, A/Prof Michael Michael, Dr Michael Christie, A/Prof Anthony Gill, Ms Kate Wilson

NHMRC Project Grant

  • 2017: $36,605

Other Public Sector Funding

Orion Conductivity Probes

Prof Leigh Ackland

  • 2014: $670

Metastasis in breast cancer cells

Prof Leigh Ackland, Miss Vidhula Ahire

  • 2015: $1,500

Industry and Other Funding

Enzymatic synthesis, microencapsulation and biological evaluation of a new class of omega-3 derived functional food ingredients

Prof Colin Barrow, Prof Ken Walder, Dr Jaroslav Kralovec, Dr Jacqui Adcock, Prof Leigh Ackland, Dr Ian Musgrave, Dr Wei Zhang

  • 2012: $70,607
  • 2011: $53,835
  • 2010: $52,910

Establishment of a Biosensor Facility at the Centre for Cellular and Molecular Biology (CCMB), Deakin University, Burwood.

A/Prof Cenk Suphioglu, Prof Leigh Ackland, Dr Sharon La Fontaine, Prof Julian Mercer

  • 2011: $50,000

Establishment of a Flow Cytometry Facility at the Centre for Cellular and Molecular Biology, Deakin University

A/Prof Cenk Suphioglu, Prof Leigh Ackland, Dr Sharon La Fontaine, Prof Julian Mercer

  • 2010: $30,000

Optimisation of the carotenoid biosynthesis from Haematococcus pluvialis

Dr Angel Torriero, Prof Leigh Ackland

  • 2014: $28,140

Preliminary screening of a saltwater lake sample to identify potentially useful pigment molecules

Dr Angel Torriero, Mr Lee Hudek, Prof Leigh Ackland

  • 2014: $5,000

A Feasibility Study Of NAB-Paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas (NABNEC)

Dr Mustafa Khasraw, Prof Leigh Ackland

  • 2015: $12,500

Characterisation of magnetic or other beads modified with proteins

Prof Leigh Ackland, Dr Angel Torriero

  • 2015: $10,000

Other Funding Sources

Epigenetic markers as indicators of predisposition to diabetes pilot study

Prof Leigh Ackland

  • 2014: $8,000
  • 2012: $45,000

Supervisions

Principal Supervisor
2016

Md Ahsan Ul Bari

Thesis entitled: Effects of Different Forms of Docosahexaenoic Acid Supplementations on Human Neuronal Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2013

David Freestone

Thesis entitled: Copper Homeostasis in Human Mammary Epithelial Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2012

Lee Hudek

Thesis entitled: Metal Uptake and Efflux Mechanisms in Nostoc Punctiforme

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2010

Lisa Jane McCarthy

Thesis entitled: Assessment of Shark Cartilage Extract from Two Commercially Viable Species

Master of Science (Ecology & Environment), School of Life and Environmental Sciences

2008

Kristy Shield

Thesis entitled: In Vitro Spheroids and Metastatic Epithelial Ovarian Cancer

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2007

Stephanie Chantal Lebret

Thesis entitled: Epithelial-Stromal Interactions in Mammary Lineage Development and Carcinogenesis

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2006

Belinda Mary Hardman

Thesis entitled: Copper Transporters in the Human Placenta

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2005

Agnieszka Michalczyk

Thesis entitled: The Function of Zinc Transporter Genes in Human Cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Executive Supervisor
2017

Shilpi Vajpai

Thesis entitled: Characterisation of chromium interactions with Aspergillus flavus

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2016

Sandeep Karbhari Sure

Thesis entitled: Cyanobacterial Nanowires and Characterisation of Cell-Metalloid/Metal Interactions

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

Associate Supervisor
2016

Ankita Bedi

Thesis entitled: Bioleaching-an approach for synthesizing functionalized nanoformulations for agricultural use

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2015

Nayyar Ahmed

Thesis entitled: Identification and Characterisation of a Novel Interleukin-4 Receptor Antagonist for Allergy Treatment

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Patricia Corbett

Thesis entitled: Histopathological Fish Health Index: a Biomarker of Pollution Effect

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Loveleen Kumar

Thesis entitled: Function of zinc transporters in human cells

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2014

Dwan Price

Thesis entitled: Molecular and immunological analysis of food allergens

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

Bianca Jade Sfiligoj

Thesis entitled: Sensitivity of Antarctic marine invertebrates and microalgae to metal exposure

Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences

2012

Nadia Sadli

Thesis entitled: Zinc and docosahexaenoic acid metabolism in brain cells

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2011

Sara Wilkinson

Thesis entitled: The Relationship between Building Adaptation and Property Attributes

Doctor of Philosophy (Architecture), School of Life and Environmental Sciences

Jane Allardyce

Thesis entitled: Defence Mechanisms of a Resistant Monocot Model to Phytophthora Cinnamomi

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2010

Tiffany Gunning

Thesis entitled: Profiling Secondary Metabolites of Plant Roots Inoculated with Phytophthora cinnamomi

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2005

Dian Wirawan Tjondronegoro

Thesis entitled: Content-based Video Indexing for Sports Applications using Integrated Multi-Modal Approac

Doctor of Philosophy (Information Technology), School of Information Technology