Dr Michael Cater

STAFF PROFILE

Position

Lecturer In Molecular Genetics

Faculty

Faculty of Sci Eng & Built Env

Department

School of Life & Env. Sciences

Campus

Melbourne Burwood Campus

Contact

michael.cater@deakin.edu.au
+61 3 925 17388

Biography

Dr. Michael Cater is a Movember Young Investigator and Heads the Metals in Medicine Laboratory within the Centre for Cellular and Molecular Biology (CCMB). Michael’s career focus in metals has expanded into the fields of general physiology, neuroscience and cancer research. Michael completed his Doctoral degree at Deakin University (2005) investigating metal-homeostatic mechanisms in the body, under the supervision of geneticist Professor Julian Mercer. This research focused on determining the molecular basis behind the hepatic copper accumulation seen in Wilson’s disease patients. He continued to pursue metals research into his first post-doc position at the Mental Health Research Institute (MHRI) (University of Melbourne), but in relation to Alzheimer’s disease treatment and neuronal function. This position provided invaluable exposure to pharmacological studies, testing metal-based compounds as an intervention for Alzheimer's disease. While at MHRI, Michael realized the potential for copper-based compounds to be used in the treatment of cancer. He therefore switched research focus to the cancer field and relocated to the Peter MacCallum Cancer Centre (beginning of 2010). Michael was awarded the prestigious NHMRC Biomedical Training Research Fellowship and more recently a CIA led NHMRC Project Grant, a CIA led Prostate Cancer Foundation of Australia (PCFA) grant and several philanthropic grants (e.g. CASS). He is an Honorary Fellow at the University of Melbourne (Department of Pathology). In 2013, Michael established his research group, the Metals in Medicine Laboratory, which has now grown to include a post-doc, 3 PhD students and one Honours student.

Read more on Michael's profile

Affiliations

Honorary, Department of Pathology, The University of Melbourne.

http://www.findanexpert.unimelb.edu.au/display/person23897

Publications

Filter by

2016

Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway

Ms Yann Yap, Dr Roxana Llanos, Dr Sharon La Fontaine, Dr Michael Cater, Prof Philip Beart, Dr Steve Cheung

(2016), Vol. 41, pp. 554-567, Neurochemical research, New York, N.Y., C1

journal

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution

Dr Delphine Denoyer, Helen Pearson, Miss Sharnel Clatworthy, Dr Zoe Smith, Prof Paul Francis, Dr Roxana Llanos, Irene Volitakis, Wayne Phillips, Mr Peter Meggyesy, Mr Shashank Masaldan, Dr Michael Cater

(2016), Vol. 7, pp. 37064-37080, Oncotarget, Albany, N.Y., C1

journal

Ceruloplasmin is regulated by copper and lactational hormones in PMC42-LA mammary epithelial cell culture models

Dr David Freestone, Dr Delphine Denoyer, Mr MATTHEW JAKAB, Prof Leigh Ackland, Dr Michael Cater, Dr Agnes Michalczyk

(2016), Vol. 8, pp. 941-950, Metallomics, Cambridge, Eng., C1

journal
2015

Targeting copper in cancer therapy: ‘copper that cancer’

Dr Delphine Denoyer, Mr Shashank Masaldan, Dr Sharon La Fontaine, Dr Michael Cater

(2015), Vol. 7, pp. 1459-1476, Metallomics, London, Eng., C1

journal

Heterogeneous copper concentrations in cancerous human prostate tissues

Dr Delphine Denoyer, Miss Sharnel Clatworthy, Mr Shashank Masaldan, Mr Peter Meggyesy, Dr Michael Cater

(2015), Vol. 75, pp. 1510-1517, Prostate, London, Eng., C1

journal
2014

Copper and lactational hormones influence the CTR1 copper transporter in PMC42-LA mammary epithelial cell culture models

Dr David Freestone, Dr Michael Cater, Prof Leigh Ackland, David Paterson, Daryl Howard, Martin de Jonge, Dr Agnes Michalczyk

(2014), Vol. 25, pp. 377-387, Journal of Nutritional Biochemistry, New York, NY, C1

journal

Glutaredoxin1 protects neuronal cells from copper-induced toxicity

Dr Michael Cater, Ms Stephanie Materia, Dr Zhiguang Xiao, Dr Kamil Wolyniec, Miss Susan Ackland, Yannwan Yap, Dr Steve Cheung, Dr Sharon La Fontaine

(2014), Vol. 27, pp. 661-672, Biometals, New York, N.Y., C1

journal
2013

Increasing intracellular bioavailable copper selectively targets prostate cancer cells

Dr Michael Cater, Helen Pearson, Dr Kamil Wolyniec, Paul Klaver, Maree Bilandzic, Brett M. Paterson, Ashley I Bush, Patrick O Humbert, Dr Sharon La Fontaine, Dr Paul Stephen Donnelly, Ygal Haupt

(2013), Vol. 8, pp. 1621-1631, ACS chemical biology, Washington, D.C., C1

journal
2012

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B

Ms Stephanie Materia, Dr Michael Cater, Leo W. J. Klomp, Prof Julian Mercer, Dr Sharon La Fontaine

(2012), Vol. 287, pp. 2485-2499, Journal of biological chemistry, Bethesda, Md., C1

journal

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II

Paul S. Donnelly, Jeffrey R. Liddell, SinChun Lim, Brett M. Paterson, Dr Michael Cater, Maria S. Savva, Alexandra I. Mot, Janine L. James, Ian A. Trounce, Anthony White, Peter J. Crouch

(2012), Vol. 109, pp. 47-52, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1-1

journal
2011

Clusterin (APOJ) : a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B

Ms Stephanie Materia, Dr Michael Cater, Leo W. J. Klomp, Prof Julian Mercer, Dr Sharon La Fontaine

(2011), Vol. 286, pp. 10073-10083, Journal of biological chemistry, Bethesda, Md., C1

journal

Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer

Dr Michael Cater, Ygal Haupt

(2011), Vol. 436, pp. 481-491, Biochemical journal, London, England, C1-1

journal
2010

Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B

Mr William Christopher Singleton, Miss Kelly McInnes, Dr Michael Cater, Wendy R. Winnal, Mr Ross McKirdy, Yu Yu, Dr Philip Taylor, Bi Xia Ke, Des R. Richardson, Prof Julian Mercer, Dr Sharon La Fontaine

(2010), Vol. 285, pp. 27111-27121, Journal of biological chemistry, Bethesda, Md., C1

journal

Iron-export ferroxidase activity of β-amyloid protein precursor is inhibited by zinc in Alzheimer's disease

James Duce, Andrew Tsatsanis, Dr Michael Cater, Dr Simon James, Elysia Robb, Krutika Wihke, S L Leong, K Perez, Timothy Johanssen, Mark Greenough, Hyun-Hee Cho, Denise Galatis, Robert Moir, C Masters, Catriona A. McLean, Rudolph Tanzi, R Cappai, Kevin J. Barnham, Giuseppe D. Ciccotosto, Jack Rogers, Ashley I Bush

(2010), Vol. 142, pp. 857-867, Cell, Cambridge, Mass., C1-1

journal

Syntaxin 5 is required for copper homeostasis in drosophila and mammals

Melanie Norgate, Adam G Southon, Mark Greenough, Dr Michael Cater, Ashley Farlow, Philip Batterham, Ashley I Bush, Nathan Subramaniam, Richard Burke, Prof James Camakaris

(2010), Vol. 5, pp. 1-10, PLoS one, San Francisco, Calif., C1-1

journal
2008

Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms

Dr Michael Cater, Miss Kelly McInnes, Qiao-Xin Li, Irene Volitakis, Dr Sharon La Fontaine, Prof Julian Mercer, Ashley I Bush

(2008), Vol. 412, pp. 141-152, Biochemical journal, London, England, C1-1

journal
2007

Copper binding to the N-terminal metal-binding sites or the CPC motif is not essential for copper-induced trafficking of the human Wilson Protein (ATP7B)

Dr Michael Cater, Dr Sharon La Fontaine, Prof Julian Mercer

(2007), Vol. 401, pp. 143-153, Biochemical journal, London, England, C1

journal
2006

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

Dr Chris Lim, Dr Michael Cater, Prof Julian Mercer, Dr Sharon La Fontaine

(2006), Vol. 348, pp. 428-436, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal

Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A

Dr Chris Lim, Dr Michael Cater, Prof Julian Mercer, Dr Sharon La Fontaine

(2006), Vol. 281, pp. 14006-14014, Journal of biological chemistry, Bethesda, Md, C1

journal

Copper in mammals: mechanisms of homeostasis and pathophysiology

Dr Michael Cater, Prof Julian Mercer

(2006), pp. 101-120, Molecular biology of metal homeostasis and detoxification : from microbes to man, Berlin, Germany, B1

chapter

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

Dr Michael Cater, Dr Sharon La Fontaine, Miss Kristy Shield, Yolanda Deal, Prof Julian Mercer

(2006), Vol. 130, pp. 493-506, Gastroenterology, Amsterdam, Nertherlands, C1

journal
2004

Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites

Dr Michael Cater, John Forbes, Dr Sharon La Fontaine, Diane Cox, Prof Julian Mercer

(2004), Vol. 380, pp. 805-813, Biochemical journal, London, England, C1

journal

Expression and localization of Menkes and Wilson copper transporting ATPases in human placenta

Ms Belinda Mary Hardman, U Manuelpillai, E Wallace, S van de Waasenburg, Dr Michael Cater, Prof Julian Mercer, Prof Leigh Ackland

(2004), Vol. 25, pp. 512-517, Placenta, Amsterdam, Netherlands, C1

journal
2002

Copper-regulated trafficking of the Menkes disease copper ATPase associated with formation of a phosphorylated catalytic intermediate

Dr Michael Petris, Ilia Voskoboinik, Dr Michael Cater, Kathryn Smith, Byung-Eun Kim, Dr Roxana Llanos, Dr Daniel Strausak, Prof James Camakaris, Prof Julian Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Baltimore, Md., C1

journal

Grants

Australian Competitive Grants

Copper-ionophores as a treatment for prostate cancer?

Dr Michael Cater

NHMRC Project Grant

  • 2014: $106,522
  • 2013: $104,741

Can copper be used to selectively kill prostate cancer cells?

Dr Michael Cater

PCFA Grant - Research - Young Investigator Grant - Prostate Cancer Foundation of Australia Limited

  • 2016: $4,965
  • 2015: $101,747
  • 2014: $101,747
  • 2013: $101,747

Industry and Other Funding

Is Prostate Cancer Development Dependent on Copper ?

Dr Michael Cater

  • 2014: $45,000

Supervisions

No completed student supervisions to report