AsPr Paul Lewandowski

STAFF PROFILE

Position

Associate Professor

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Bachelor of Science, Deakin University, 1995
Doctor of Philosophy, Deakin University, 1999

Contact

Research interests

Dr Lewandowski has a growing research program aimed at understanding how nutrition can be used to treat or prevent the development of age associated diseases including cancer cachexia, obesity and metabolic syndrome. Much of this work has involved combining cutting-edge molecular biology and laboratory techniques with dietary modification to treat disease, with a focus on at-risk rural and migrant populations.

Teaching interests

Dr Lewandowski serves as coordinator of anatomy in the Deakin Medical School, with overall responsibility for the teaching anatomy across the medical course. Dr Lewandowski also supervises honours and PhD students.

Awards

Dr Lewandowski was awarded the professional tile of Registered Nutritionist (RNutr) in 2010 and has received funding from both National Competitive Grant Schemes and Industry. He has also received a highly competitive Australian Nutrition Trust Fund travelling fellowship.

Projects

The over-arching goal of Dr Lewandowski’s research is to use diet and lifestyle to treat and prevent chronic disease. In attempting to achieve this goal he utilises a range of molecular biology techniques, biochemical tools, animal models and clinical samples to measure biomarkers of disease. Based on the understanding gained and mechanisms identified he then formulates dietary interventions to treat the condition. Dr Lewandowski currently heads a productive research team within the School of Medicine at Deakin University investigating three key research topics:


1. Oxidative stress. Increased levels of free radicals are known to be at the heart of a number of chronic diseases. Dr Lewandowski’s research group has investigated the mechanistic role oxidative stress plays in the development of fatty liver disease, metabolic syndrome, aging and muscle wasting. He has supervised an Alfred Deakin Postdoctoral Fellow, had 4 PhD students graduate and published 21 articles in this research area.


2. Metabolic syndrome. The increased prevalence of Metabolic Syndrome in the past 30 years and has become a major health concern in at risk populations, including migrants and people living in rural areas. Using biomarkers to diagnose and track the progress of diet and lifestyle interventions. His research group has had great success in treating metabolic syndrome in Pakistani migrants and farmers. This research theme currently employs 1 postdoctoral fellow, has had 3 PhD students graduate and published 23 articles.


3. Cancer cachexia. Unfortunately cachexia is a significant complication for a number of cancer patients, many of whom are terminally ill. Using a number of mouse models of cancer cachexia Dr Lewandowski’s research group has been investigating the underlying mechanisms that contribute to the development of the disease and have tested a number of new therapies that are now translating into the clinical setting. The mouse models are used in preclinical studies and complemented by a collaboration with the Barwon Health cachexia clinic. This ability to readily translate outcomes into the clinic has attracted considerable commercial funding. As a result of this commercial interest, investigations by his group into the treatment of cancer cachexia have seen this area grow rapidly over the past two years. Involving 2 postdoctoral fellows, had 1 PhD student graduate, published 4 articles and contributed to 2 patents in this research area.

Publications

Filter by

2016

The addition of depression to the Framingham Risk Equation model for predicting coronary heart disease risk in women

Adrienne O`Neil, Dr Aaron Fisher, K J Kibbey, A/Prof Felice Jacka, A/Prof Mark Kotowicz, Dr Lana Williams, Mrs Amanda Stuart, Prof Michael Berk, A/Prof Paul Lewandowski, John Atherton, Prof Craig Taylor, Prof Julie Pasco

(2016), Vol. 87, pp. 115-120, Preventive medicine, Amsterdam, The Netherlands, C1

journal

Depression is a risk factor for incident coronary heart disease in women: an 18-year longitudinal study

Adrienne O`Neil, Dr Aaron Fisher, K J Kibbey, A/Prof Felice Jacka, A/Prof Mark Kotowicz, Dr Lana Williams, Mrs Amanda Stuart, Prof Michael Berk, A/Prof Paul Lewandowski, Prof Craig Taylor, Prof Julie Pasco

(2016), Vol. 196, pp. 117-124, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal

Telomere dynamics during aging in polygenic left ventricular hypertrophy.

Francine Z. Marques, Scott A. Booth, Priscilla Prestes, Claire Curl, Lea Dellbridge, A/Prof Paul Lewandowski, Stephen B. Harrap, Prof Fadi Charchar

(2016), Vol. 48, pp. 42-49, Physiological genomics, Bethesda, Md, C1

journal
2015

Cholinesterase Research Outreach Project (CROP): measuring cholinesterase activity and pesticide use in an agricultural community

Dr Jacquie Cotton, A/Prof Paul Lewandowski, Capr Susan Brumby

(2015), Vol. 15, pp. 1-6, BMC public health, London, Eng., C1

journal

What is the most effective way of increasing the bioavailability of dietary long chain omega-3 fatty acids-daily vs. weekly administration of fish oil?

Miss Samaneh Ghasemi Fard, Prof Andrew Sinclair, Dr Gunveen Kaur, A/Prof Paul Lewandowski, A/Prof Giovanni Turchini

(2015), Vol. 7, pp. 5628-5645, Nutrients, Basel, Switzerland, C1

journal

Forms of n-3 (ALA, C18:3n-3 or DHA, C22:6n-3) fatty acids affect carcass yield, blood lipids, muscle n-3 fatty acids and liver gene expression in lambs

A/Prof Paul Lewandowski, Fahri T Fahri, Viv Burnett, Frank R. Dunshea, Tim Plozza, Joe Jacobs

(2015), Vol. 50, pp. 1133-1143, Lipids, Berlin, Germany, C1

journal
2014

Methylmercury-induced inhibition of paraoxonase-1 (PON1)-implications for cardiovascular risk

G Ginsberg, B Sonawane, R Nath, A/Prof Paul Lewandowski

(2014), Vol. 77, pp. 1004-1023, Journal of toxicology and environmental health, Part A: current issues, London, Eng., C1

journal

Postexercise muscle cooling enhances gene expression of PGC-1α

Mohammed Ihsan, Greig Watson, Hui Cheng Choo, A/Prof Paul Lewandowski, Ms Annateresa Papazzo, A/Prof David Cameron-Smith, Chris R. Abbiss

(2014), Vol. 46, pp. 1900-1907, Medicine and science in sports and exercise, Philadelphia, PA, C1

journal

The impact of supplementing lambs with algae on growth, meat traits and oxidative status

D L Hopkins, E H Clayton, T A Lamb, R van de Ven, G Refshauge, M J Kerr, K Bailes, A/Prof Paul Lewandowski, Eric Ponnampalam

(2014), Vol. 98, pp. 135-141, Meat science, Amsterdam, Netherlands, C1

journal
2013

Cancer cachexia : impact, mechanisms and emerging treatments

Dr Vanessa Vaughan, A/Prof Peter Martin, A/Prof Paul Lewandowski

(2013), Vol. 4, pp. 95-109, Journal of cachexia, sarcopenia and muscle, Berlin, Germany, C1

journal

The growth performance of Jade Tiger cultured abalone fed diets supplemented with fish oil and vegetable oils

H. T. Mateos, A/Prof Paul Lewandowski, X. Q. Su

(2013), Vol. 93, pp. 1389-1396, Journal of the science of food agriculture, Chichester, England, C1

journal

Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage

Dr Scott A Nankervis, Jenee M. Mitchell, Prof Fadi Charchar, Ms Maree Mcglynn, A/Prof Paul Lewandowski

(2013), Vol. 2, pp. 1-13, Longevity and healthspan, London, England, C1

journal

Marine polyunsaturated fatty acids and cancer therapy

Dr Vanessa Vaughan, Mollie-Rose Hassing, A/Prof Paul Lewandowski

(2013), Vol. 108, pp. 486-492, British journal of cancer, London, England, C1

journal

Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction

Ms Annateresa Papazzo, Dr Xavier Conlan, Louise Lexis, Prof Fadi Charchar, A/Prof Paul Lewandowski

(2013), Vol. 8, pp. 1-9, PLoS one, San Francisco, Calif., C1

journal

Health impacts of eicosapentaenoic acid and docosahexaenoic acid

Mr Hintsa Mateos, A/Prof Paul Lewandowski, Dr Vanessa Vaughan, X. Q. Su

(2013), Vol. 8, pp. 1-12, CAB reviews : perspectives in agriculture, veterinary science, nutrition and natural resources, Oxfordshire, England, C1

journal
2012

Effects of dietary fish oil replacement with flaxseed oil on tissue fatty acid composition and expression of desaturase and elongase genes

H. T. Mateos, A/Prof Paul Lewandowski, X. Q. Su

(2012), Vol. 92, pp. 418-426, Journal of the science of food and agriculture, West Sussex, U. K., C1

journal

Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBPIc with no effect on body weight or liver fat

Mr Mile Janevski, Dr Sunil Ratnayake, Svetlana Siljanovski, Ms Maree Mcglynn, A/Prof David Cameron-Smith, A/Prof Paul Lewandowski

(2012), Vol. 3, pp. 141-149, Food and function, Cambridge, England, C1

journal

Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia

Dr Vanessa Vaughan, Dr Melanie Sullivan-Gunn, Mr Edward Hinch, A/Prof Peter Martin, A/Prof Paul Lewandowski

(2012), Vol. 7, pp. 1-8, PLoS one, San Francisco, Calif., C1

journal

The effect of replacing dietary fish oil with canola oil on fatty acid composition and expression of desaturase and elongase genes in Jade Tiger hybrid abalone

Mr Hintsa Mateos, A/Prof Paul Lewandowski, X. Q. Su

(2012), Vol. 131, pp. 1217-1222, Food chemistry, Amsterdam, The Netherlands, C1

journal

The growth performance of Jade Tiger cultured abalone fed diets supplemented with fish oil and vegetable oils

Mr Hintsa Mateos, A/Prof Paul Lewandowski, X. Q. Su

(2012), Vol. 93, pp. 1389-1396, Journal of the science of food and agriculture, London, England, C1-1

journal
2011

Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle

Dr Melanie Sullivan-Gunn, Siun P. Campbell-O'Sullivan, Michael J. Tisdale, A/Prof Paul Lewandowski

(2011), Vol. 2, pp. 181-188, Journal of cachexia, sarcopenia and muscle, Berlin, Germany, C1

journal

Dietary fish oil supplements increase tissue n-3 fatty acid composition and expression of delta-6 desaturase and elongase-2 in jade tiger hybrid abalone

H. T. Mateos, A/Prof Paul Lewandowski, X. Q. Su

(2011), Vol. 46, pp. 741-751, Lipids, Heidelberg, Germany, C1

journal

Differential effects of natural palm oil, chemically and enzymatically-modified palm oil on weight gain, blood lipid metabolites and fat deposition in a pediatric pig model

Eric Ponnampalam, A/Prof Paul Lewandowski, Kalanithi Nesaratnam, Frank R. Dunshea, Harsharn Gill

(2011), Vol. 10, pp. 1-7, Nutrition journal, London, U. K., C1

journal

The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH

Mr Mile Janevski, Kiriakos N. Antonas, Dr Melanie Sullivan-Gunn, Ms Maree Mcglynn, A/Prof Paul Lewandowski

(2011), Vol. 10, pp. 1-13, Comparative hepatology, London, U. K., C1

journal

Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats

Ms Annateresa Papazzo, Dr Xavier Conlan, Louise Lexis, A/Prof Paul Lewandowski

(2011), Vol. 10, pp. 1-8, Lipids in health and diease, London, England, C1

journal

The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

Ms Annateresa Papazzo, Dr Xavier Conlan, Louise Lexis, A/Prof Paul Lewandowski

(2011), Vol. 10, pp. 1-10, Lipids in health and disease, London, U. K., C1

journal
2010

Seasonal variations of total lipid and fatty acid contents in muscle, gonad and digestive glands of farmed jade tiger hybrid abalone in Australia

H. T. Mateos, A/Prof Paul Lewandowski, X. Q. Su

(2010), Vol. 123, pp. 436-441, Food chemistry, Amsterdam, The Netherlands, C1

journal

CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle

Ms Annateresa Papazzo, Louise Lexis, A/Prof Paul Lewandowski

(2010), Vol. 2, pp. 51-58, Nutrition and Dietary Supplements, Auckland, N.Z., C1

journal

Rapid bioassay-guided screening of toxic substances in vegetable oils that shorten the life of SHRSP rats

Dr Sunil Ratnayake, A/Prof Paul Lewandowski

(2010), Vol. 9, pp. 3-14, Lipids in health and disease, London, England, C1

journal
2009

A culturally appropriate program to treat metabolic syndrome in female Pakistani immigrants

Rizwana Kousar, J. Antonas, Dr Cate Burns, A/Prof Paul Lewandowski

(2009), Vol. 55, pp. 1502-1508, Annals of nutrition and metabolism, Basal, Switzerland, C1-1

journal
2008

Investigation of telomere lengths measurement by quantitative real-time PCR to predict age

Sudinna Hewakapuge, Roland van Oorshot, A/Prof Paul Lewandowski, Swati Baindur-Hudson

(2008), Vol. 10, pp. 236-242, Legal medicine, Amsterdam, The Netherlands, C1

journal

A culturally appropriate diet and lifestyle intervention can successfully treat the components of metabolic syndrome in female Pakistani immigrants residing in Melbourne, Australia

Rizwana Kousar, Dr Cate Burns, A/Prof Paul Lewandowski

(2008), Vol. 57, pp. 1502-1508, Metabolism : clinical and experimental, Amsterdam, The Netherlands, C1

journal
2007

Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans

Michelle Micallef, Louise Lexis, A/Prof Paul Lewandowski

(2007), Vol. 6, pp. 1-8, Nutrition journal, London, England, C1

journal