A/Prof. Paul Lewandowski

STAFF PROFILE

Position

Associate Professor

Campus

Geelong Waurn Ponds Campus

Qualifications

Bachelor of Science, Deakin University, 1995
Doctor of Philosophy, Deakin University, 1999

Contact

Research interests

Dr Lewandowski has a growing research program aimed at understanding how nutrition can be used to treat or prevent the development of age associated diseases including cancer cachexia, obesity and metabolic syndrome. Much of this work has involved combining cutting-edge molecular biology and laboratory techniques with dietary modification to treat disease, with a focus on at-risk rural and migrant populations.

Teaching interests

Dr Lewandowski serves as coordinator of anatomy in the Deakin Medical School, with overall responsibility for the teaching anatomy across the medical course. Dr Lewandowski also supervises honours and PhD students.

Awards

Dr Lewandowski was awarded the professional tile of Registered Nutritionist (RNutr) in 2010 and has received funding from both National Competitive Grant Schemes and Industry. He has also received a highly competitive Australian Nutrition Trust Fund travelling fellowship.

Projects

The over-arching goal of Dr Lewandowski’s research is to use diet and lifestyle to treat and prevent chronic disease. In attempting to achieve this goal he utilises a range of molecular biology techniques, biochemical tools, animal models and clinical samples to measure biomarkers of disease. Based on the understanding gained and mechanisms identified he then formulates dietary interventions to treat the condition. Dr Lewandowski currently heads a productive research team within the School of Medicine at Deakin University investigating three key research topics:


1. Oxidative stress. Increased levels of free radicals are known to be at the heart of a number of chronic diseases. Dr Lewandowski’s research group has investigated the mechanistic role oxidative stress plays in the development of fatty liver disease, metabolic syndrome, aging and muscle wasting. He has supervised an Alfred Deakin Postdoctoral Fellow, had 4 PhD students graduate and published 21 articles in this research area.


2. Metabolic syndrome. The increased prevalence of Metabolic Syndrome in the past 30 years and has become a major health concern in at risk populations, including migrants and people living in rural areas. Using biomarkers to diagnose and track the progress of diet and lifestyle interventions. His research group has had great success in treating metabolic syndrome in Pakistani migrants and farmers. This research theme currently employs 1 postdoctoral fellow, has had 3 PhD students graduate and published 23 articles.


3. Cancer cachexia. Unfortunately cachexia is a significant complication for a number of cancer patients, many of whom are terminally ill. Using a number of mouse models of cancer cachexia Dr Lewandowski’s research group has been investigating the underlying mechanisms that contribute to the development of the disease and have tested a number of new therapies that are now translating into the clinical setting. The mouse models are used in preclinical studies and complemented by a collaboration with the Barwon Health cachexia clinic. This ability to readily translate outcomes into the clinic has attracted considerable commercial funding. As a result of this commercial interest, investigations by his group into the treatment of cancer cachexia have seen this area grow rapidly over the past two years. Involving 2 postdoctoral fellows, had 1 PhD student graduate, published 4 articles and contributed to 2 patents in this research area.

Publications

Filter by

2017

Comparisons of the postprandial inflammatory and endotoxaemic responses to mixed meals in young and older individuals: a randomised trial

A Milan, S Pundir, C Pileggi, J Markworth, P Lewandowski, D Cameron-Smith

(2017), Vol. 9, pp. 1-16, Nutrients, Basel, Switzerland, C1

journal
2016

Telomere dynamics during aging in polygenic left ventricular hypertrophy.

F Marques, S Booth, P Prestes, C Curl, L Delbridge, P Lewandowski, S Harrap, F Charchar

(2016), Vol. 48, pp. 42-49, Physiological genomics, Bethesda, Md, C1

journal

Tripartite motif-containing 55 identified as functional candidate for spontaneous cardiac hypertrophy in the rat locus cardiac mass 22

P Prestes, F Marques, G Lopez-Campos, S Booth, M McGlynn, P Lewandowski, L Delbridge, S Harrap, F Charchar

(2016), Vol. 34, pp. 950-958, Journal of hypertension, Philadelphia, Pa., C1

journal

Depression is a risk factor for incident coronary heart disease in women: an 18-year longitudinal study

A O'Neil, A Fisher, K Kibbey, F Jacka, M Kotowicz, L Williams, A Stuart, M Berk, P Lewandowski, C Taylor, J Pasco

(2016), Vol. 196, pp. 117-124, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal

The addition of depression to the Framingham Risk Equation model for predicting coronary heart disease risk in women

A O'Neil, A Fisher, K Kibbey, F Jacka, M Kotowicz, L Williams, A Stuart, M Berk, P Lewandowski, J Atherton, C Taylor, J Pasco

(2016), Vol. 87, pp. 115-120, Preventive Medicine Reports, Amsterdam, The Netherlands, C1

journal

The expression of genes encoding enzymes regulating fat metabolism is affected by maternal nutrition when lambs are fed algae high in omega-3

T Alvarenga, Y Chen, P Lewandowski, E Ponnampalam, S Sadiq, E Clayton, R van de Ven, J Perez, D Hopkins

(2016), Vol. 187, pp. 53-60, Livestock science, Amsterdam, The Netherlands, C1

journal

MicroRNAs in a hypertrophic heart: from foetal life to adulthood

S Sadiq, T Crowley, F Charchar, A Sanigorski, P Lewandowski

(2016), pp. 1-18, Biological reviews : Cambridge philosophical society, Chichester, Eng., C1

journal

Oxidized fish oil in rat pregnancy causes high newborn mortality and increases maternal insulin resistance

B Albert, M Vickers, C Gray, C Reynolds, S Segovia, J Derraik, P Lewandowski, M Garg, D Cameron-Smith, P Hofman, W Cutfield

(2016), Vol. 311, pp. R497-R504, American journal of physiology. Regulatory, integrative and comparative physiology, Bethesda, Md., C1

journal
2015

What is the most effective way of increasing the bioavailability of dietary long chain omega-3 fatty acids-daily vs. weekly administration of fish oil?

S Ghasemifard, A Sinclair, G Kaur, P Lewandowski, G Turchini

(2015), Vol. 7, pp. 5628-5645, Nutrients, Basel, Switzerland, C1

journal

Cholinesterase Research Outreach Project (CROP): measuring cholinesterase activity and pesticide use in an agricultural community

J Cotton, P Lewandowski, S Brumby

(2015), Vol. 15, pp. 1-6, BMC public health, London, Eng., C1

journal

Forms of n-3 (ALA, C18:3n-3 or DHA, C22:6n-3) fatty acids affect carcass yield, blood lipids, muscle n-3 fatty acids and liver gene expression in lambs

E Ponnampalam, P Lewandowski, F Fahri, V Burnett, F Dunshea, T Plozza, J Jacobs

(2015), Vol. 50, pp. 1133-1143, Lipids, Berlin, Germany, C1

journal
2014

The impact of supplementing lambs with algae on growth, meat traits and oxidative status

D Hopkins, E Clayton, T Lamb, R van de Ven, G Refshauge, M Kerr, K Bailes, P Lewandowski, E Ponnampalam

(2014), Vol. 98, pp. 135-141, Meat science, Amsterdam, Netherlands, C1

journal

Postexercise muscle cooling enhances gene expression of PGC-1?

M Ihsan, G Watson, H Choo, P Lewandowski, A Papazzo, D Cameron-Smith, C Abbiss

(2014), Vol. 46, pp. 1900-1907, Medicine and science in sports and exercise, Philadelphia, PA, C1

journal

Methylmercury-induced inhibition of paraoxonase-1 (PON1)-implications for cardiovascular risk

G Ginsberg, B Sonawane, R Nath, P Lewandowski

(2014), Vol. 77, pp. 1004-1023, Journal of toxicology and environmental health, Part A: current issues, Abingdon, Eng., C1

journal
2013

The growth performance of Jade Tiger cultured abalone fed diets supplemented with fish oil and vegetable oils

H Mateos, P Lewandowski, X Su

(2013), Vol. 93, pp. 1389-1396, Journal of the science of food agriculture, Chichester, England, C1

journal

Cancer cachexia : impact, mechanisms and emerging treatments

V Vaughan, P Martin, P Lewandowski

(2013), Vol. 4, pp. 95-109, Journal of cachexia, sarcopenia and muscle, [Berlin, Germany], C1

journal

Health impacts of eicosapentaenoic acid and docosahexaenoic acid

H Mateos, P Lewandowski, V Vaughan, X Su

(2013), Vol. 8, pp. 1-12, CAB reviews : perspectives in agriculture, veterinary science, nutrition and natural resources, Oxfordshire, England, C1

journal

Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage

S Nankervis, S Nankervis, J Mitchell, J Mitchell, F Charchar, F Charchar, M McGlynn, M McGlynn, P Lewandowski, P Lewandowski

(2013), Vol. 2, pp. 1-13, Longevity and healthspan, London, Eng., C1

journal

Marine polyunsaturated fatty acids and cancer therapy

V Vaughan, M Hassing, P Lewandowski

(2013), Vol. 108, pp. 486-492, British journal of cancer, London, England, C1

journal

Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction

A Papazzo, X Conlan, L Lexis, F Charchar, P Lewandowski

(2013), Vol. 8, pp. 1-9, PLoS one, San Francisco, Calif., C1

journal

The effect of physical activity on psychological distress, cortisol and obesity: results of the farming fit intervention program

S Brumby, A Chandrasekara, P Kremer, S Torres, S McCoombe, P Lewandowski

(2013), Vol. 13, pp. 1-15, BMC public health, London, England, C1

journal

Disruption of pro-oxidant and antioxidant systems with elevated expression of the ubiquitin proteosome system in the cachectic heart muscle of nude mice

E Hinch, M Sullivan-Gunn, V Vaughan, M McGlynn, P Lewandowski

(2013), Vol. 4, pp. 287-293, Journal of cachexia, sarcopenia and muscle, Berlin, Germany, C1-1

journal

Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia

M Sullivan-Gunn, P Lewandowski

(2013), Vol. 13, pp. 1-9, BMC geriatrics, London, Eng., C1-1

journal
2012

Effects of dietary fish oil replacement with flaxseed oil on tissue fatty acid composition and expression of desaturase and elongase genes

H Mateos, P Lewandowski, X Su

(2012), Vol. 92, pp. 418-426, Journal of the science of food and agriculture, West Sussex, U. K., C1

journal

Cardiovascular risk factors and psychological distress in Australian farming communities

S Brumby, A Chandrasekara, S McCoombe, P Kremer, P Lewandowski

(2012), Vol. 20, pp. 131-137, Australian journal of rural health, Richmond, Vic., C1

journal

Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia

V Vaughan, M Sullivan-Gunn, E Hinch, P Martin, P Lewandowski

(2012), Vol. 7, pp. 1-8, PLoS one, San Francisco, Calif., C1

journal

Fructose containing sugars modulate mRNA of lipogenic genes ACC and FAS and protein levels of transcription factors ChREBP and SREBPIc with no effect on body weight or liver fat

M Janevski, S Ratnayake, S Siljanovski, M McGlynn, D Cameron-Smith, P Lewandowski

(2012), Vol. 3, pp. 141-149, Food and function, Cambridge, England, C1

journal

The effect of replacing dietary fish oil with canola oil on fatty acid composition and expression of desaturase and elongase genes in Jade Tiger hybrid abalone

H Mateos, P Lewandowski, X Su

(2012), Vol. 131, pp. 1217-1222, Food chemistry, Amsterdam, The Netherlands, C1

journal
2011

Farming fit? Dispelling the Australian agrarian myth.

S Brumby, A Chandrasekara, S McCoombe, P Kremer, P Lewandowski

(2011), Vol. 4, BMC Research Notes, London, England, C1

journal

Reducing psychological distress and obesity in Australian farmers by promoting physical activity

S Brumby, A Chandrasekara, S McCoombe, S Torres, P Kremer, P Lewandowski

(2011), Vol. 11, pp. 1-7, BMC Public Health, London, England, C1

journal

Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle

M Sullivan-Gunn, S Campbell-O'Sullivan, M Tisdale, P Lewandowski

(2011), Vol. 2, pp. 181-188, Journal of cachexia, sarcopenia and muscle, [Berlin, Germany], C1

journal

Differential effects of natural palm oil, chemically and enzymatically-modified palm oil on weight gain, blood lipid metabolites and fat deposition in a pediatric pig model

E Ponnampalam, P Lewandowski, K Nesaratnam, F Dunshea, H Gill

(2011), Vol. 10, pp. 1-7, Nutrition journal, London, U. K., C1

journal

The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

A Papazzo, X Conlan, L Lexis, P Lewandowski

(2011), Vol. 10, pp. 1-10, Lipids in health and disease, London, U. K., C1

journal

Differential effects of dietary canola and soybean oil intake on oxidative stress in stroke-prone spontaneously hypertensive rats

A Papazzo, X Conlan, L Lexis, P Lewandowski

(2011), Vol. 10, pp. 1-8, Lipids in health and diease, London, England, C1

journal

Dietary fish oil supplements increase tissue n-3 fatty acid composition and expression of delta-6 desaturase and elongase-2 in jade tiger hybrid abalone

H Mateos, P Lewandowski, X Su

(2011), Vol. 46, pp. 741-751, Lipids, Heidelberg, Germany, C1

journal

The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH

M Janevski, K Antonas, M Sullivan-Gunn, M McGlynn, P Lewandowski

(2011), Vol. 10, pp. 1-13, Comparative hepatology, London, U. K., C1

journal
2010

Rapid bioassay-guided screening of toxic substances in vegetable oils that shorten the life of SHRSP rats

S Ratnayake, P Lewandowski

(2010), Vol. 9, pp. 3-14, Lipids in health and disease, London, England, C1

journal

CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle

A Papazzo, L Lexis, P Lewandowski

(2010), Vol. 2, pp. 51-58, Nutrition and Dietary Supplements, Auckland, N.Z., C1

journal

Seasonal variations of total lipid and fatty acid contents in muscle, gonad and digestive glands of farmed jade tiger hybrid abalone in Australia

H Mateos, P Lewandowski, X Su

(2010), Vol. 123, pp. 436-441, Food chemistry, Amsterdam, The Netherlands, C1

journal
2009

Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet

N Chen, R Bezzina, E Hinch, P Lewandowski, D Cameron-Smith, M Mathai, M Jois, A Sinclair, D Begg, J Wark, H Weisinger, R Weisinger

(2009), Vol. 29, pp. 784-793, Nutrition research, New York, N.Y., C1

journal

A culturally appropriate program to treat metabolic syndrome in female Pakistani immigrants

R Kousar, J Antonas, C Burns, P Lewandowski

(2009), Vol. 55, pp. 1502-1508, Annals of nutrition and metabolism, Basal, Switzerland, C1-1

journal
2008

A culturally appropriate diet and lifestyle intervention can successfully treat the components of metabolic syndrome in female Pakistani immigrants residing in Melbourne, Australia

R Kousar, C Burns, P Lewandowski

(2008), Vol. 57, pp. 1502-1508, Metabolism : clinical and experimental, Amsterdam, The Netherlands, C1

journal

Investigation of telomere lengths measurement by quantitative real-time PCR to predict age

S Hewakapuge, R van Oorshot, P Lewandowski, S Baindur-Hudson

(2008), Vol. 10, pp. 236-242, Legal medicine, Amsterdam, The Netherlands, C1

journal
2007

Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans

M Micallef, L Lexis, P Lewandowski

(2007), Vol. 6, pp. 1-8, Nutrition journal, London, England, C1

journal
2000

Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus

A Sanigorski, D Cameron-Smith, P Lewandowski, K Walder, A de Silva, G Morton, G Collier

(2000), Vol. 164, pp. 45-50, Journal of endocrinology, Bristol, England, C1-1

journal
1999

Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM : Psammomys obesus

K Walder, P Lewandowski, G Morton, A Sanigorski, A de Silva, P Zimmet, G Collier

(1999), Vol. 23, pp. 83-89, International journal of obesity, London, England, C1-1

journal
1998

The role of lipogenesis in the development of obesity and diabetes in Israeli sand rats (Psammomys obesus)

P Lewandowski, D Cameron-Smith, C Jackson, E Kultys, G Collier

(1998), Vol. 128, pp. 1984-1988, Journal of Nutrition, Bethesda, Md., C1-1

journal
1997

Leptin and the development of obesity and diabetes in Psammomys obesus

G Collier, K Walder, P Lewandowski, A Sanigorski, P Zimmet

(1997), Vol. 5, pp. 455-458, Obesity research, Silver Spring, Md., C1-1

journal

Disproportionate increase of fatty acid binding proteins in the livers of obese diabetic Psammomys obesus

P Lewandowski, D Cameron-Smith, K Moulton, K Walder, A Sanigorski, G Collier

(1997), Vol. 827, pp. 536-540, Annals of the New York academy of sciences, Hoboken, N. J., C1-1

journal

The effect of dietary energy restriction on body weight gain and the development of noninsulin-dependent diabetes mellitus (NIDDM) in Psammomys obesus

K Walder, C Dascaliuc, P Lewandowski, A Sanigorski, P Zimmet, G Collier

(1997), Vol. 5, pp. 193-200, Obesity research, London, England, C1-1

journal

Funded Projects at Deakin

Other Public Sector Funding

Farming Fit?: Depression and obesity in farm men and women

Prof Susan Brumby, Dr Ananda Chandrasekara, Dr Scott Mccoombe, Dr Peter Kremer, A/Prof Paul Lewandowski

  • 2011: $49,650
  • 2010: $39,720
  • 2009: $9,930

Treatment of muscle wasting with NatraGuard in a mouse model of cancer cachexia

A/Prof Paul Lewandowski

  • 2013: $38,886
  • 2012: $38,390
  • 2010: $18,947

Oxypurinol and Eicosapentaenoic Acid in the Treatment of skeletal muscle wasting in cancer-induced cachexia

A/Prof Paul Lewandowski, Miss Vanessa Caron Vaughan

  • 2013: $12,714
  • 2012: $25,426
  • 2011: $25,631
  • 2010: $12,714

Effect of Linseed supplementation on liver gene expression in lamb

A/Prof Paul Lewandowski

  • 2012: $76,937

Measurements of Isoprostane in samples from sheep

A/Prof Paul Lewandowski

  • 2014: $10,000

Other Funding Sources

Supply of Services Agreement - Animal Housing, breeding and husbandry

A/Prof Paul Lewandowski

  • 2013: $50,000

Supervisions

Principal Supervisor
2015

Samaneh Ghasemi Fard

Thesis entitled: Bioavailability of long chain omega-3 polyunsaturated fatty acids

Doctor of Philosophy (Medicine), School of Medicine

Edward Hinch

Thesis entitled: Mechanisms and treatment of cardiac atrophy secondary to cancer cachexia

Doctor of Philosophy (Medicine), School of Medicine

2014

Vanessa Caron Vaughan

Thesis entitled: Cancer Cachexia: A Molecular Nutrition Approach to Cancer-Related Muscle Loss

Doctor of Philosophy (Medicine), School of Medicine

Gregory Van Egmond

Thesis entitled: Acute postprandial effects of high fat ingestion on oxidative status

Doctor of Philosophy (Medicine), School of Medicine

2012

Annateresa Papazzo

Thesis entitled: Canola Oil Intake, Oxidative Status and Lifespan in SHRSP Rats

Doctor of Philosophy (Medicine), School of Medicine

2011

Mile Janevski

Thesis entitled: Theobroma Cacao (Cocoa) Supplementation in the Treatment of Non-alcoholic Steatohepatitis

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2016

Hadi Al Shamaileh

Thesis entitled: Aptamer-mediated siRNA delivery to target colon cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine