Dr Roxana Llanos

STAFF PROFILE

Position

Casual Academic

Faculty

Faculty of Health

Department

School of Medicine

Campus

Melbourne Burwood Campus

Qualifications

Bachelor of Science, Monash University, 1987
Doctor of Philosophy, University of Melbourne, 1995

Contact

roxana.llanos@deakin.edu.au
+61 3 924 45431

Biography summary

I have been involved in several research projects since the completion of a BSc (Honours) degree in 1986 and a PhD project in March 1995.  These include the immunological identification of Campylobacter generic probes from a C. jejuni genomic library (1987-1988, Monash University); cloning, mapping and expression of genes which encode key enzymes in the conversion of hexoses to lactic acid in Lactococcus lactis (1989-1996, The University of Melbourne); study of the molecular basis of microtubule nucleation, characterization of centrosomal components and the involvement of γ tubulin in this nucleation process (1996-1998, Grenoble, France); study of mammalian copper metabolism using cell and mouse models (2000 - 2015, Deakin University) and study of cell cycle genes involvement in excitotoxic neuronal death (2012 - present, Deakin University).

Knowledge areas

Protein trafficking/Protein localisation

Generation of transgenic mice

Mouse models with altered expression of copper transport genes

Menkes disease/Wilson disease/Neuropathy

Excitotoxicity/Neuronal cell death

Publications

Filter by

2016

Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway

Y Yap, R Llanos, S La Fontaine, M Cater, P Beart, N Cheung

(2016), Vol. 41, pp. 554-567, Neurochemical research, New York, N.Y., C1

journal

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution

D Denoyer, H Pearson, S Clatworthy, Z Smith, P Francis, R Llanos, I Volitakis, W Phillips, P Meggyesy, S Masaldan, M Cater

(2016), Vol. 7, pp. 37064-37080, Oncotarget, Albany, N.Y., C1

journal

Characterizing the molecular phenotype of an Atp7a(T985I) conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX)

G Perez-Siles, A Grant, M Ellis, C Ly, A Kidambi, M Khalil, R Llanos, S La Fontaine, A Strickland, S Züchner, S Bermeo, E Neist, T Brennan-Speranza, R Takata, C Speck-Martins, J Mercer, G Nicholson, M Kennerson

(2016), pp. 981-882, Metallomics: integrated biometal science, Cambridge, Eng., C1

journal
2014

Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation

J Wadwa, Y Chu, N Nguyen, T Henson, A Figueroa, R Llanos, M Ackland, A Michalczyk, H Fullriede, G Brennan, J Mercer, M Linder

(2014), Vol. 2, pp. 1-11, Physiological Reports, Oxford, United Kingdom, C1

journal

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

B Roberts, N Lim, E McAllum, P Donnelly, D Hare, P Doble, B Turner, K Price, S Lim, B Paterson, J Hickey, T Rhoads, J Williams, K Kanninen, L Hung, J Liddell, A Grubman, J Monty, R Llanos, D Kramer, J Mercer, A Bush, C Masters, J Duce, Q Li, J Beckman, K Barnham, A White, P Crouch

(2014), Vol. 34, pp. 8021-8031, Journal of neuroscience, Washington, D.C., C1

journal
2013

Gene expression profiling of rotenone-mediated cortical neuronal death : evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling

Y Yap, M Chen, Z Peng, J Manikandan, J Ng, R Llanos, S La Fontaine, P Beart, N Cheung

(2013), Vol. 62, pp. 653-663, Neurochemistry international, Amsterdam, The Netherlands, C1

journal

Gene profiling identifies commonalities in neuronal pathways in excitotoxicity : evidence favouring cell cycle re-activation in concert with oxidative stress

M Chen, J Ng, Z Peng, J Manikandan, Y Yap, R Llanos, P Beart, N Cheung

(2013), Vol. 62, pp. 719-730, Neurochemistry international, Amsterdam, The Netherlands, C1

journal

Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase

V Sudhahar, N Urao, J Oshikawa, R McKinney, R Llanos, J Mercer, M Ushio-Fukai, T Fukai

(2013), Vol. 62, pp. 3839-3850, Diabetes, Alexandria, Va., C1-1

journal
2010

Missense mutations in the copper transporter gene ATP7A cause X-Linked distal hereditary motor neuropathy

M Kennerson, G Nicholson, S Kaler, B Kowalski, J Mercer, J Tang, R Llanos, S Chu, R Takata, C Speck-Martins, J Baets, L Almeida-Souza, D Fischer, V Timmerman, P Taylor, S Scherer, T Ferguson, T Bird, P De Jonghe, S Feely, M Shy, J Garbern

(2010), Vol. 86, pp. 342-352, American journal of human genetics, Cambridge, Mass., C1-1

journal
2008

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

R Llanos, A Michalczyk, D Freestone, S Currie, M Linder, M Ackland, J Mercer

(2008), Vol. 372, pp. 613-617, Biochemical and biophysical research communications, San Diego, Calif., C1

journal

ATP7A transgenic and nontransgenic mice are resistant to high copper exposure

B Ke, R Llanos, J Mercer

(2008), Vol. 138, pp. 693-697, Journal of nutrition, Bethesda, Md., C1-1

journal
2006

Correction of a mouse model of Menkes disease by the human Menkes gene

R Llanos, B Ke, M Wright, Y Deal, F Monty, D Kramer, J Mercer

(2006), Vol. 1762, pp. 485-493, Biochimica et biophysica acta (BBA) - molecular basis of disease, Amsterdam, The Netherlands, C1

journal

Alteration of copper physiology in mice overexpressing the human menkes protein ATP7A

B Ke, R Llanos, M Wright, Y Deal, J Mercer

(2006), Vol. 290, pp. 1460-1467, American journal of physiology : regulatory, interative comparative physiology, Bethesda, Md., C1

journal
2005

Copper exposure induces trafficking of the Menkes protein in intestinal epithelium of ATP7A transgenic mice

J Monty, R Llanos, J Mercer, D Kramer

(2005), Vol. 135, pp. 2762-2766, Journal of nutrition, Bethesda, Md., C1

journal
2003

Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

D Kramer, R Llanos, J Mercer

(2003), pp. 207-244, Metal ions and neurodegenerative disorders, Singapore, B1

chapter

Molecular and cellular aspects of copper transport in developing mammals

J Mercer, R Llanos

(2003), Vol. 133, Journal of nutrition, Bethesda, Md., C1

journal

Copper-induced trafficking of the Cu-ATPase: a key mechanism for copper homeostasis

J Mercer, N Barnes, J Stevenson, D Strausak, R Llanos

(2003), Vol. 16, pp. 175-184, BioMetals, Amsterdam, The Netherlands, C1

journal
2002

The molecular basis of copper homeostasis and copper-related disorders

R Llanos, J Mercer

(2002), Vol. 21, pp. 259-270, DNA and cell biology, New York, N.Y., C1

journal

Copper-regulated trafficking of the Menkes disease copper ATPase associated with formation of a phosphorylated catalytic intermediate

M Petris, I Voskoboinik, M Cater, K Smith, B Kim, R Llanos, D Strausak, J Camakaris, J Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Baltimore, Md., C1

journal

Funded Projects at Deakin

Other Funding Sources

Travel Grant -The Ian Potter Foundation

Dr Roxana Llanos

  • 2006: $2,000

Supervisions

Associate Supervisor
2006

Alanna Castelli

Thesis entitled: Mutation Analysis of the Menkes Gene

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2003

Natalie Barnes

Thesis entitled: Structure Function Studies of Mammalian Copper ATPases

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences