Dr Sarah Shigdar

STAFF PROFILE

Position

Senior Lecturer in Medical Science

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Bachelor of Science (Biological Science), University of Wolverhampton, 1995
Doctor of Philosophy, Deakin University, 2009

Contact

sarah.shigdar@deakin.edu.au
+61 3 522 72846

Research interests

Dr Shigdar is focused on the development of aptamers, also known as chemical antibodies, for their use in both diagnostic and therapeutic applications. Dr Shigdar's main focus is on the use of aptamers for the treatment of neurological disorders - brain cancers, brain metastases, and neurodegenerative disorders

Units taught

HMM101 Introduction to Medical Biotechnology

HMM304 Therapeutic Development

HMH401 Developing Research Skills

Knowledge areas

Aptamers

Professional activities

President International Society of Aptamers 2016 -

Awards

Smart Geelong Awards - Researcher of the Year 2011 – Population Health and Lifestyle - 'Establishing a Platform for the Generation of RNA Missiles Targeting Cancer Initiating Cells'

Smart Geelong Awards - Early Career Researcher of the Year 2013 - 'Getting the brain to take its medicine – development of a smart platform to treat tumour metastases'

Projects

Aptamers as theranostic agents

Getting the brain to take its medicine

Publications

Filter by

2017

Challenges and opportunities for siRNA-based cancer treatment

T Wang, S Shigdar, H Al Shamaileh, M Gantier, W Yin, D Xiang, L Wang, S-F Zhou, Y Hou, P Wang, W Zhang, C Pu, W Duan

(2017), Vol. 387, pp. 77-83, Cancer letters, Shannon, Ireland, C1

journal

Development of a bifunctional aptamer targeting the transferrin receptor and epithelial cell adhesion molecule (EpCAM) for the treatment of brain cancer metastases

J Macdonald, J Henri, L Goodman, D Xiang, W Duan, S Shigdar

(2017), Vol. 8, pp. 777-784, ACS chemical neuroscience, Washington, D.C., C1

journal
2016

Application of Aptamers in Histopathology.

S Shigdar, L Lv, L Wang, W Duan

(2016), Vol. 1380, pp. 191-196, Nucleic acid aptamers : selection, characterization and application, New York, N.Y., B1

chapter

The Application of aptamers for immunohistochemistry

M Bauer, J Macdonald, J Henri, W Duan, S Shigdar

(2016), Vol. 26, pp. 120-126, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal

Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis

X She, L Chen, Z Yi, C Li, C He, C Feng, T Wang, S Shigdar, W Duan, L Kong

(2016), Vol. 16, pp. 1-40, Mini-reviews in medicinal chemistry, Beijing, China, C1

journal

Truncation and mutation of a transferrin receptor aptamer enhance binding affinity

J Macdonald, P Houghton, D Xiang, W Duan, S Shigdar

(2016), Vol. 26, pp. 348-354, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal
2015

Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine

D Xiang, S Shigdar, G Qiao, T Wang, A Kouzani, S Zhou, L Kong, Y Li, C Pu, W Duan

(2015), Vol. 5, pp. 23-42, Theranostics, Wyoming, N.S.W., C1

journal

Aptamer-mediated cancer gene therapy.

D Xiang, S Shigdar, G Qiao, S Zhou, Y Li, M Wei, L Qiao, H Shamaileh, Y Zhu, C Zheng, C Pu, W Duan

(2015), Vol. 15, pp. 109-119, Current Gene Therapy, Bussum, Netherlands, C1

journal

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery.

X She, L Chen, L Velleman, C Li, H Zhu, C He, T Wang, S Shigdar, W Duan, L Kong

(2015), Vol. 445, pp. 151-160, Journal of Colloid and Interface Science, United States, C1

journal

The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery

X She, L Chen, L Velleman, C Li, C He, J Denman, T Wang, S Shigdar, W Duan, L Kong

(2015), Vol. 3, pp. 6094-6104, Journal of materials chemistry B, Cambridge, Eng., C1

journal

Superior performance of aptamer in tumor penetration over antibody : implication of aptamer-based theranostics in solid tumors

D Xiang, C Zheng, S Zhou, S Qiao, P Tran, C Pu, Y Li, L Kong, A Kouzani, J Lin, K Liu, L Li, S Shigdar, W Duan

(2015), Vol. 5, pp. 1083-1097, Theranostics, Sydney, N.S.W., C1

journal

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

L Chen, X She, T Wang, L He, S Shigdar, W Duan, L Kong

(2015), Vol. 7, pp. 14080-14092, Nanoscale, Cambridge, Eng., C1

journal

Cancer stem cell targeted therapy: progress amid controversies

T Wang, S Shigdar, M Gantier,, Y Hou,, L Wang,, Y Li,, H Shamaileh,, W Yin, S Zhou,, X Zhao,, W Duan

(2015), Vol. 6, pp. 44191-44206, Oncotarget, Albany, N.Y., C1

journal

EpCAM aptamer-mediated survivin silencing sensitized cancer stem cells to doxorubicin in a breast cancer model

T Wang, M Gantier, D Xiang, A Bean, M Bruce, S Zhou, M Khasraw, A Ward, L Wang, M Wei, H AlShamaileh, L Chen, X She, J Lin, L Kong, S Shigdar, W Duan

(2015), Vol. 5, pp. 1456-1472, Theranostics, Wyoming, N.S.W., C1

journal

Cytokine networks and cancer stem cells

C Liongue, A Ward, W Duan, S Shigdar

(2015), pp. 67-87, Cancer stem cells : emerging concepts and future perspectives in translational oncology, Berlin, Germany, B1

chapter
2014

Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model

J Lin, S Shigdar, D Fang, D Xiang, M Wei, A Danks, L Kong, L Li, L Qiao, W Duan

(2014), Vol. 9, pp. 1-13, Plos One, San Francisco, CA, C1

journal

Cancer stem cells: a contentious hypothesis now moving forward

M O'Connor, D Xiang, S Shigdar, J Macdonald, Y Li, T Wang, C Pu, Z Wang, L Qiao, W Duan

(2014), Vol. 344, pp. 180-187, Cancer letters, Shannon, Ireland, C1

journal

CD44 variant 6 is associated with prostate cancer metastasis and chemo-/radioresistance

J Ni, P Cozzi, J Hao, J Beretov, L Chang, W Duan, S Shigdar, W Delprado, P Graham, J Bucci, J Kearsley, Y Li

(2014), Vol. 74, pp. 602-617, Prostate, Hoboken, NJ, C1

journal

Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells

L Li, D Xiang, S Shigdar, W Yang, Q Li, J Lin, K Liu, W Duan

(2014), Vol. 9, pp. 1083-1096, International journal of nanomedicine, Macclesfield, England, C1

journal
2013

RNA aptamers targeting cancer stem cell marker CD133

S Shigdar, L Qiao, S Zhou, D Xiang, T Wang, Y Li, L Lim, L Kong, L Li, W Duan

(2013), Vol. 330, pp. 84-95, Cancer letters, Amsterdam, Netherlands, C1

journal

The use of sensitive chemical antibodies for diagnosis: detection of low levels of Epcam in breast cancer

S Shigdar, C Qian, L Lv, C Pu, Y Li, L Li, M Marappan, J Lin, L Wang, W Duan

(2013), Vol. 8, pp. 1-8, PLoS One, San Diego, United States, C1

journal

Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

J Ni, P Cozzi, J Hao, J Beretov, L Chang, W Duan, S Shigdar, W Delprado, P Graham, J Bucci, J Kearsley, Y Li

(2013), Vol. 45, pp. 2736-2748, International journal of biochemistry and cell biology, Amsterdam, The Netherlands, C1

journal

Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo

D Xiang, Z Yang, W Duan, X Li, J Yin, S Shigdar, M O'Connor, M Marappan, X Zhao, Y Miao, B Xiang, C Zheng

(2013), Vol. 8, pp. 4103-4114, International Journal of Nanomedicine, Macclesfield, UK, C1

journal

Inflammation and cancer stem cells

S Shigdar, Y Li, S Bhattacharya, M O'Connor, C Pu, J Lin, T Wang, D Xiang, L Kong, M Wei, Y Zhu, S Zhou, W Duan

(2013), Vol. 345, pp. 271-278, Cancer letters, Amsterdam, The Netherlands, C1

journal

Aptamers as theranostic agents: modifications, serum stability and functionalisation

S Shigdar, J Macdonald, M O'Connor, T Wang, D Xiang, H Al.Shamaileh, L Qiao, M Wei, S Zhou, Y Zhu, L Kong, S Bhattacharya, C Li, W Duan

(2013), Vol. 13, pp. 13624-13637, Sensors, Basel, Switzerland, C1

journal
2012

Cancer stem cell targeting : the next generation of cancer therapy and molecular imaging

S Shigdar, J Lin, Y Li, C Yang, M Wei, Y Zhu, H Liu, W Duan

(2012), Vol. 3, pp. 227-244, Therapeutic delivery, London, England, C1

journal

Enhanced antitumor efficacy and reduced systemic toxicity of sulfatide containing nanoliposomal doxorubicin in a xenograft model of colorectal cancer

J Lin, Y Yu, S Shigdar, D Fang, J Rong Du, M Wei, A Danks, K Liu, W Duan

(2012), Vol. 7, pp. 1-10, Plos One, San Francisco, Calif., C1-1

journal

Role of the EpCAM (CD326) in prostate cancer metastasis and progression

J Ni, P Cozzi, W Duan, S Shigdar, P Graham, K John, Y Li

(2012), Vol. 31, pp. 779-791, Cancer metastasis reviews, New York, N. Y., C1

journal

Aptamers and nanomedicine

S Shigdar, A Smith, W Duan

(2012), pp. 275-296, Nanotechnology in health care, Singapore, Singapore, B1-1

chapter
2011

Groundwater pre-treatment prevents the onset of chronic ulcerative dermatopathy in juvenile Murray cod, Maccullochella peelii peelii (Mitchell)

A Schultz, S Shigdar, P Jones, A Ward, T Toop

(2011), Vol. 312, pp. 19-25, Aquaculture, Amsterdam, Netherlands, C1

journal

Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults

J Lin, D Fang, J Du, S Shigdar, L Xiao, X Zhou, W Duan

(2011), Vol. 58, pp. 150-157, Annals of nutrition and metabolism, Basel, Switzerland, C1

journal

Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies

S Shigdar, A Ward, A De, C Yang, M Wei, W Duan

(2011), Vol. 155, pp. 3-13, British journal of haematology, Oxford, U. K., C1

journal

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

S Shigdar, J Lin, Y Yu, M Pastuovic, M Wei, W Duan

(2011), Vol. 102, pp. 991-998, Cancer Science, Tokyo, Japan, C1-1

journal
2010

Aptamer therapeutics: the 21st century's magic bullet of nanomedicine

S Shigdar, J Luczo, M Wei, R Bell, A Danks, K Liu, D Wei

(2010), Vol. 1, pp. 118-124, Open conference proceedings journal, Bussum, The Netherlands, C1-1

journal

TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults

J Du, D Fang, J Lin, L Xiao, X Zhou, S Shigdar, W Duan

(2010), Vol. 21, pp. 1114-1119, Journal of nutritional biochemistry, New York, N.Y., C1-1

journal
2009

Cytochemical characterisation of the leucocytes and thrombocytes from murray cod (Maccullochella peelii peelii, Mitchell)

S Shigdar, A Harford, A Ward

(2009), Vol. 26, pp. 731-736, Fish and shellfish immunology, Amsterdam, The Netherlands, C1

journal
2008

Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia

A Ward, J Gits, F Majeed, A Aprikyan, R Lewis, L O`Sullivan, M Freedman, S Shigdar, I Touw, D Dale, Y Dror

(2008), Vol. 142, pp. 653-656, British journal of haematology, Oxford, England, C1

journal
2007

Blood cells of Murray cod maccullochella peelii peelii (Mitchell)

S Shigdar, D Cook, P Jones, A Harford, A Ward

(2007), Vol. 70, pp. 973-980, Journal of fish biology, Oxford, England, C1

journal
2003

The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion

P Dodson, J Haynes, J Starczynski, J Farmer, S Shigdar, G Fegan, R Johnson, C Fegan

(2003), Vol. 17, pp. 772-777, Eye, London, England, C1-1

journal

Grants

Industry and Other Funding

Improving Cancer Diagnostics By Using Chemical Flags - Cancer Research Scholarship

Prof Alister Ward, Dr Sarah Shigdar

  • 2016: $14,000
  • 2015: $14,000

Supervisions

Principal Supervisor
2015

Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2016

Hadi Al Shamaileh

Thesis entitled: Aptamer-mediated siRNA delivery to target colon cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine

Lijue Chen

Thesis entitled: Delivery of Fluorouracil and siRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer

Doctor of Philosophy (Engineering), Institute for Frontier Materials

2015

Dongxi Xiang

Thesis entitled: Developing RNA aptamer technology for targeting cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine

2014

Tao Wang

Thesis entitled: An aptamer-mediated siRNA delivery system targeting breast tumourigenic cells

Doctor of Philosophy (Medicine), School of Medicine

Manju Marappan

Thesis entitled: Efficacy of utilizing chemical antibodies in histopathological studies

MAppSc (Medicine) (High cost), School of Medicine