Dr Sarah Shigdar

STAFF PROFILE

Position

Senior Lecturer in Medical Science

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Contact

sarah.shigdar@deakin.edu.au
+61 3 522 72846

Research interests

Dr Shigdar is focused on the development of aptamers, also known as chemical antibodies, for their use in both diagnostic and therapeutic applications. Dr Shigdar's main focus is on the use of aptamers for the treatment of neurological disorders - brain cancers, brain metastases, and neurodegenerative disorders

Units taught

HMM101 Introduction to Medical Biotechnology

HMM304 Therapeutic Development

HMH401 Developing Research Skills

Knowledge areas

Aptamers

Professional activities

President International Society of Aptamers 2016 -

Awards

Smart Geelong Awards - Researcher of the Year 2011 – Population Health and Lifestyle - 'Establishing a Platform for the Generation of RNA Missiles Targeting Cancer Initiating Cells'

Smart Geelong Awards - Early Career Researcher of the Year 2013 - 'Getting the brain to take its medicine – development of a smart platform to treat tumour metastases'

Projects

Aptamers as theranostic agents

Getting the brain to take its medicine

Publications

Filter by

2017

Challenges and opportunities for siRNA-based cancer treatment

Mr Tao Wang, Dr Sarah Shigdar, Mr Hadi Al Shamaileh, Michael P. Gantier, Mr Wang Yin, Mr Dongxi Xiang, Lan Wang, Shu-Feng Zhou, Yingchun Hou, Peng Wang, Weihong Zhang, Chenwen Pu, Prof Wei Duan

(2017), Vol. 387, pp. 77-83, Cancer letters, Shannon, Ireland, C1

journal
2016

Application of Aptamers in Histopathology.

Dr Sarah Shigdar, Li Lv, Lifen Wang, Prof Wei Duan

(2016), pp. 191-196, Nucleic acid aptamers : selection, characterization and application, New York, N.Y., B1

chapter

Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis

Ms Xiaodong She, Dr Lijue Chen, Dr Zhifeng Yi, Mr Chengpeng Li, Canzhong He, Miss Chunfang Feng, Mr Tao Wang, Dr Sarah Shigdar, Prof Wei Duan, Prof Lingxue Kong

(2016), Vol. 16, pp. 1-40, Mini-reviews in medicinal chemistry, Beijing, China, C1

journal

The application of aptamers for immunohistochemistry

Ms Michelle Bauer, Ms Joanna Macdonald, Mr Justin Liam Henri, Prof Wei Duan, Dr Sarah Shigdar

(2016), Vol. 26, pp. 120-126, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal

Truncation and mutation of a transferrin receptor aptamer enhance binding affinity

Ms Joanna Macdonald, Mr Patrick John Houghton, Mr Dongxi Xiang, Prof Wei Duan, Dr Sarah Shigdar

(2016), Vol. 26, pp. 348-354, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal
2015

Aptamer-mediated cancer gene therapy

Mr Dongxi Xiang, Dr Sarah Shigdar, Greg G. Qiao, Shu-Feng Zhou, Dr Yong Li, Ming Q. Wei, Liang Qiao, Hadi Shamaileh, Yimin Zhu, Conglong Zheng, Prof Wei Duan

(2015), Vol. 15, pp. 109-119, Current Gene Therapy, Bussum, Netherlands, C1

journal

Cytokine networks and cancer stem cells

Mr Clifford Liongue, Prof Alister Ward, Prof Wei Duan, Dr Sarah Shigdar

(2015), pp. 67-87, Cancer stem cells : emerging concepts and future perspectives in translational oncology, Berlin, Germany, B1

chapter

EpCAM aptamer-mediated survivin silencing sensitized cancer stem cells to doxorubicin in a breast cancer model

Mr Tao Wang, Michael P. Gantier, Mr Dongxi Xiang, Andrew G.D Bean, Matthew P Bruce, Shu-Feng Zhou, Dr Mustafa Khasraw, Prof Alister Ward, Li Wang, ming wei, Mr Hadi Al Shamaileh, Dr Lijue Chen, Ms Xiaodong She, Ms Jia Lin, Prof Lingxue Kong, Dr Sarah Shigdar, Prof Wei Duan

(2015), Vol. 5, pp. 1456-1472, Theranostics, Wyoming, N.S.W., C1

journal

Cancer stem cell targeted therapy: progress amid controversies

Mr Tao Wang, Dr Sarah Shigdar, Michael P. Gantier, Yingchun Hou, Li Wang, Dr Yong Li, Mr Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao, Prof Wei Duan

(2015), Vol. 6, pp. 44191-44206, Oncotarget, Albany, N.Y., C1

journal

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

Dr Lijue Chen, Ms Xiaodong She, Mr Tao Wang, Dr Li He, Dr Sarah Shigdar, Prof Wei Duan, Prof Lingxue Kong

(2015), Vol. 7, pp. 14080-14092, Nanoscale, Cambridge, Eng., C1

journal

The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery

Ms Xiaodong She, Dr Lijue Chen, Dr Leonora Velleman, Mr Chengpeng Li, Canzhong He, John Denman, Mr Tao Wang, Dr Sarah Shigdar, Prof Wei Duan, Prof Lingxue Kong

(2015), Vol. 3, pp. 6094-6104, Journal of materials chemistry B, Cambridge, Eng., C1

journal

Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine

Mr Dongxi Xiang, Dr Sarah Shigdar, Greg G. Qiao, Mr Tao Wang, Prof Abbas Kouzani, Shu-Feng Zhou, Prof Lingxue Kong, Dr Yong Li, Chunwen Pu, Prof Wei Duan

(2015), Vol. 5, pp. 23-42, Theranostics, Wyoming, N.S.W., C1

journal

Superior performance of aptamer in tumor penetration over antibody : implication of aptamer-based theranostics in solid tumors

Mr Dongxi Xiang, Conglong Zheng, Shu-Feng Zhou, Shuxi Qiao, Dr Phuong Tran, Chunwen Pu, Yong Li, Prof Lingxue Kong, Prof Abbas Kouzani, Ms Jia Lin, Ke Liu, Lianhong Li, Dr Sarah Shigdar, Prof Wei Duan

(2015), Vol. 5, pp. 1083-1097, Theranostics, Sydney, N.S.W., C1

journal
2014

Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells

Mr Lei Li, Mr Dongxi Xiang, Dr Sarah Shigdar, Dr Wenrong Yang, Qiong Li, Ms Jia Lin, Kexin Liu, Prof Wei Duan

(2014), Vol. 9, pp. 1083-1096, International journal of nanomedicine, Macclesfield, England, C1

journal

Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model

Ms Jia Lin, Dr Sarah Shigdar, Ding Zhi Fang, Dognxi Xiang, Ming Qian Wei, A/Prof Andrew Danks, Prof Lingxue Kong, Lianghong Li, Liang Qiao, Prof Wei Duan

(2014), Vol. 9, pp. 1-13, Plos One, San Francisco, CA, C1

journal

CD44 variant 6 is associated with prostate cancer metastasis and chemo-/radioresistance.

Jie Ni, Paul J. Cozzi, Jingli Hao, Julia Beretov, Lei Chang, Prof Wei Duan, Dr Sarah Shigdar, Warick Delprado, Peter H. Graham, Joseph Bucci, John Kearsley, Dr Yong Li

(2014), Vol. 74, pp. 602-617, Prostate, Hoboken, NJ, C1

journal

Cancer stem cells: a contentious hypothesis now moving forward

Michael O Connor, Mr Dongxi Xiang, Dr Sarah Shigdar, Ms Joanna Macdonald, Dr Yong Li, Mr Tao Wang, Chunwen Pu, Zhidong Wang, Liang Qiao, Prof Wei Duan

(2014), Vol. 344, pp. 180-187, Cancer letters, Shannon, Ireland, C1

journal

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery.

Ms Xiaodong She, Dr Lijue Chen, Dr Leonora Velleman, Mr Chengpeng Li, Dr Haijin Zhu, Canzhong He, Mr Tao Wang, Dr Sarah Shigdar, Prof Wei Duan, Prof Lingxue Kong

(2014), Vol. 445, pp. 151-160, Journal of Colloid and Interface Science, United States, C1

journal
2013

RNA aptamers targeting cancer stem cell marker CD133

Dr Sarah Shigdar, Liang Qiao, Shu-Feng Zhou, Mr Dongxi Xiang, Mr Tao Wang, Dr Yong Li, Lee Yong Lim, Prof Lingxue Kong, Lianhong Li, Prof Wei Duan

(2013), Vol. 330, pp. 84-95, Cancer letters, Amsterdam, Netherlands, C1

journal

The use of sensitive chemical antibodies for diagnosis: detection of low levels of Epcam in breast cancer

Dr Sarah Shigdar, Ms Christine Qian, Li Lv, Chunwen Pu, Dr Yong Li, Ms Manju Marappan, Ms Jia Lin, Lifen Wang, Prof Wei Duan

(2013), Vol. 8, pp. 1-8, PLoS One, San Diego, United States, C1

journal

Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo

Mr Dongxi Xiang, Mr Zheng Yang, Prof Wei Duan, Xiujing Li, Jianjian Yin, Dr Sarah Shigdar, Michael Liam O`Connor, Ms Manju Marappan, Xiaojuan Zhao, Yingqiu Miao, Bin Xiang, Conglong Zheng

(2013), Vol. 8, pp. 4103-4114, International Journal of Nanomedicine, Macclesfield, UK, C1

journal

Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

Jie Ni, Paul J. Cozzi, Jingli Hao, Julia Beretov, Lei Chang, Prof Wei Duan, Dr Sarah Shigdar, Warick Delprado, Peter H. Graham, Joseph Bucci, John Kearsley, Dr Yong Li

(2013), Vol. 45, pp. 2736-2748, International journal of biochemistry and cell biology, Amsterdam, The Netherlands, C1

journal

Inflammation and cancer stem cells

Dr Sarah Shigdar, Dr Yong Li, Santuna Bhattacharya, Michael Liam O`Connor, Chunwen Pu, Ms Jia Lin, Mr Tao Wang, Mr Dongxi Xiang, Prof Lingxue Kong, Ming Qian Wei, Yimin Zhu, Prof Shufeng Zhou, Prof Wei Duan

(2013), Vol. 345, pp. 271-278, Cancer letters, Amsterdam, The Netherlands, C1

journal

Aptamers as theranostic agents: modifications, serum stability and functionalisation

Dr Sarah Shigdar, Ms Joanna Macdonald, Michael Liam O`Connor, Mr Tao Wang, Mr Dongxi Xiang, Hadi Al.Shamaileh, Liang Qiao, Ming Qian Wei, Shu-Feng Zhou, Yimin Zhu, Prof Lingxue Kong, Santanu Bhattacharya, ChunGuang Li, Prof Wei Duan

(2013), Vol. 13, pp. 13624-13637, Sensors, Basel, Switzerland, C1

journal
2012

Enhanced antitumor efficacy and reduced systemic toxicity of sulfatide containing nanoliposomal doxorubicin in a xenograft model of colorectal cancer

Ms Jia Lin, Yan Yu, Dr Sarah Shigdar, Ding Zhi Fang, Jun Rong Du, Ming Qian Wei, A/Prof Andrew Danks, Ke Liu, Prof Wei Duan

(2012), Vol. 7, pp. 1-10, Plos One, San Francisco, Calif., C1

journal

Role of the EpCAM (CD326) in prostate cancer metastasis and progression

Jie Ni, Paul J. Cozzi, Prof Wei Duan, Dr Sarah Shigdar, Peter H. Graham, Kearsley H. John, Dr Yong Li

(2012), Vol. 31, pp. 779-791, Cancer metastasis reviews, New York, N. Y., C1

journal

Cancer stem cell targeting : the next generation of cancer therapy and molecular imaging

Dr Sarah Shigdar, Ms Jia Lin, Dr Yong Li, Chaoyong J. Yang, Ming Qian Wei, Yimin Zhu, Hui Liu, Prof Wei Duan

(2012), Vol. 3, pp. 227-244, Therapeutic delivery, London, England, C1

journal

Aptamers and nanomedicine

Dr Sarah Shigdar, Adam Smith, Prof Wei Duan

(2012), pp. 275-296, Nanotechnology in health care, Singapore, Singapore, B1-1

chapter
2011

Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies

Dr Sarah Shigdar, Prof Alister Ward, Abhijit De, Chaoyong J. Yang, Ming Qian Wei, Prof Wei Duan

(2011), Vol. 155, pp. 3-13, British journal of haematology, Oxford, U. K., C1

journal

Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of AP0A5-1131T>C and AP0C3-482C> in chinese healthy young adults

Ms Jia Lin, Ding Zhi Fang, Juan Du, Dr Sarah Shigdar, Li Ying Xiao, Xue Dong Zhou, Prof Wei Duan

(2011), Vol. 58, pp. 150-157, Annals of nutrition and metabolism, Basel, Switzerland, C1

journal

Groundwater pre-treatment prevents the onset of chronic ulcerative dermatopathy in juvenile Murray cod, Maccullochella peelii peelii (Mitchell)

Dr Aaron Schultz, Dr Sarah Shigdar, Dr Paul Jones, Prof Alister Ward, Prof Tes Toop

(2011), Vol. 312, pp. 19-25, Aquaculture, Amsterdam, Netherlands, C1

journal

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

Dr Sarah Shigdar, Ms Jia Lin, Yan Yu, Mile Pastuovic, Ming Qian Wei, Prof Wei Duan

(2011), Vol. 102, pp. 991-998, Cancer Science, Tokyo, Japan, C1-1

journal
2010

Aptamer therapeutics: the 21st century's magic bullet of nanomedicine

Dr Sarah Shigdar, Jasmina Luczo, Ming Qian Wei, A/Prof Richard Bell, A/Prof Andrew Danks, Ke Liu, Prof Wei Duan

(2010), Vol. 1, pp. 118-124, Open conference proceedings journal, Bussum, The Netherlands, C1-1

journal
2009

Cytochemical characterisation of the leucocytes and thrombocytes from murray cod (Maccullochella peelii peelii, Mitchell)

Dr Sarah Shigdar, Andrew Harford, Prof Alister Ward

(2009), Vol. 26, pp. 731-736, Fish and shellfish immunology, Amsterdam, The Netherlands, C1

journal
2008

Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia

Prof Alister Ward, Judith Gits, Fidel Majeed, Andrew A Aprikyan, Dr Rowena Lord, Dr Lynda O'Sullivan, Melvin Freedman, Dr Sarah Shigdar, Ivo P Touw, David C Dale, Yigal Dror

(2008), Vol. 142, pp. 653-656, British journal of haematology, Oxford, England, C1

journal
2007

Blood cells of Murray cod maccullochella peelii peelii (Mitchell)

Dr Sarah Shigdar, Mr Dan Cook, Dr Paul Jones, Andrew Harford, Prof Alister Ward

(2007), Vol. 70, pp. 973-980, Journal of fish biology, Oxford, England, C1

journal
2003

The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion

A/Prof Michael Dodson, J Haynes, J Starczynski, J Farmer, Dr Sarah Shigdar, G Fegan, R J Johnson, C Fegan

(2003), Vol. 17, pp. 772-777, Eye, London, England, C1-1

journal

Grants

Industry and Other Funding

Improving Cancer Diagnostics By Using Chemical Flags - Cancer Research Scholarship

Prof Alister Ward, Dr Sarah Shigdar

  • 2016: $14,000
  • 2015: $14,000

Supervisions

Principal Supervisor
2015

Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2016

Hadi Al Shamaileh

Thesis entitled: Aptamer-mediated siRNA delivery to target colon cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine

Lijue Chen

Thesis entitled: Delivery of Fluorouracil and siRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer

Doctor of Philosophy (Engineering), Institute for Frontier Materials

2015

Dongxi Xiang

Thesis entitled: Developing RNA aptamer technology for targeting cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine

2014

Tao Wang

Thesis entitled: An aptamer-mediated siRNA delivery system targeting breast tumourigenic cells

Doctor of Philosophy (Medicine), School of Medicine

Manju Marappan

Thesis entitled: Efficacy of utilizing chemical antibodies in histopathological studies

MAppSc (Medicine) (High cost), School of Medicine