A/Prof. Sean Mcgee

STAFF PROFILE

Position

Associate Professor of Medical Biology

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Bachelor of Applied Science, Deakin University, 2002
Doctor of Philosophy, Deakin University, 2005
Graduate Certificate of Higher Education, Deakin University, 2011

Contact

sean.mcgee@deakin.edu.au
+61 3 522 72519

Biography

Associate Professor McGee obtained his PhD in Molecular Physiology from Deakin University in 2005 and completed postdoctoral training at the Department of Physiology, The University of Melbourne, and The Welcome Trust Biocentre, University of Dundee, Scotland. At the beginning of 2009, relocated his research program to the School of Medicine, Deakin University, where he currently heads the Metabolic Reprogramming Laboratory, within the Metabolic Research Unit.

Read more on Sean's profile

Research interests

Chronic over-nutrition is driving an epidemic of chronic diseases that includes obesity and type 2 diabetes, cardiovascular disease and cancer. Cellular metabolic reprogramming underpins the pathogenesis of all of these diseases. Our laboratory aims to understand the mechanisms that mediate metabolic reprogramming in these diseases and seeks to leverage this knowledge to develop therapies to combat the chronic disease epidemic.

Affiliations

Dr McGee is a member of the Australian Diabetes Society, the Australian Physiological Society and the American Physiological Society.

Teaching interests

Associate Professor McGee is coordinator of the Metabolism and Musculoskeletal Topic of the Knowledge of Health and Illness Theme (HME201) within the Bachelor of Medicine/Bachelor of Surgery degree. He also contributes to teaching in other subjects including Molecular Biology Techniques (SBB321) and Research Methods (HBS400). Associate Professor McGee also supervisors honours and PhD students.

Knowledge areas

Metabolism, cell signalling, transcription, obesity and type 2 diabetes, cancer metabolism, cardiac metabolism

Professional activities

NHMRC Grant Review Panel Member -  2012, 2013, 2015

Treasurer, Metabolism and Molecular Medicine Special Interest Group, The Australian Society for Biochemistry and Molecular Biology - 2014 to present

Awards

Associate Professor McGee has been awarded research funds totalling in excess of $3 million, with the majority from external National Competitive Grant Schemes, such as the National Health and Medical Research Council (NHMRC), the Diabetes Australia Research Trust (DART) and the National Breast Cancer Foundation. Dr McGee has also been awarded prestigious fellowships, including an NHMRC Peter Doherty Fellowship, the DART Viertel Fellowship and an NHMRC Career Development Fellowship. He was also awarded the AK McIntrye Medal from the Australian Physiological Society in 2010.



 

Publications

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2017

A model of the mitochondrial basis of bipolar disorder

G Morris, K Walder, S McGee, O Dean, S Tye, M Maes, M Berk

(2017), Vol. 74, pp. 1-20, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal

Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

V Gaur, T Connor, K Venardos, D Henstridge, S Martin, C Swinton, S Morrison, K Aston-Mourney, S Gehrig, R van Ewijk, G Lynch, M Febbraio, G Steinberg, M Hargreaves, K Walder, S McGee

(2017), Vol. 19, pp. 936-943, Diabetes, obesity and metabolism, Chichester, Eng., C1

journal

Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study

K De Jong, J Czeczor, S Sithara, K McEwen, G Lopaschuk, A Appelbe, K Cukier, M Kotowicz, S McGee

(2017), Vol. 16, pp. 1-12, Cardiovascular diabetology, London, Eng., C1

journal

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

journal

Exercise and the skeletal muscle epigenome

S McGee, K Walder

(2017), Vol. 7, Cold Spring Harbor Perspectives in Medicine, Cold Spring Harbor, N.Y., C1

journal

Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism

J Czeczor, S McGee

(2017), Vol. 29, pp. 1-8, Journal of neuroendocrinology, London, Eng., C1

journal

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S Preston, P Korhonen, L Mouchiroud, M Cornaglia, S McGee, N Young, R Davis, S Crawford, C Nowell, B Ansell, G Fisher, K Andrews, B Chang, M Gijs, P Sternberg, J Auwerx, J Baell, A Hofmann, A Jabbar, R Gasser

(2017), Vol. 31, pp. 4515-4532, The FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, Bethesda, Md., C1

journal
2016

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

M Coughlan, G Higgins, T-V Nguyen, S Penfold, V Thallas-Bonke, S Tan, G Ramm, N Van Bergen, D Henstridge, K Sourris, B Harcourt, I Trounce, P Robb, A Laskowski, S McGee, A Genders, K Walder, B Drew, P Gregorevic, H Qian, M Thomas, G Jerums, R Macisaac, A Skene, D Power, E Ekinci, X Wijeyeratne, L Gallo, M Herman-Edelstein, M Ryan, M Cooper, D Thorburn, J Forbes

(2016), Vol. 65, pp. 1085-1098, Diabetes, Alexandria, Va., C1

journal

A syntenic cross species aneuploidy genetic screen links RCAN1 expression to ?-cell mitochondrial dysfunction in Type 2 diabetes

H Peiris, M Duffield, J Fadista, C Jessup, V Kashmir, A Genders, S McGee, A Martin, M Saiedi, N Morton, R Carter, M Cousin, A Kokotos, N Oskolkov, P Volkov, T Hough, E Fisher, V Tybulewicz, J Busciglio, P Coskun, A Becker, P Belichenko, W Mobley, M Ryan, J Chan, D Laybutt, P Coates, S Yang, C Ling, L Groop, M Pritchard, D Keating

(2016), Vol. 12, pp. 1-24, PLoS genetics, San Francisco, Calif., C1

journal

Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

Y Kim, S McGee, J Czeczor, A Walker, R Kale, A Kouzani, K Walder, M Berk, S Tye

(2016), Vol. 6, pp. 1-7, Translational psychiatry, London, Eng., C1

journal

Epigenetic regulation of skeletal muscle metabolism

K Howlett, S McGee

(2016), Vol. 130, pp. 1051-1063, Clinical science, London, Eng., C1

journal

Screening of the 'pathogen box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

S Preston, Y Jiao, A Jabbar, S McGee, B Laleu, P Willis, T Wells, R Gasser

(2016), Vol. 6, pp. 329-334, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1

journal

?-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Müller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschöp, M Watt, I Clarke, C Roth, K Grove, M Cowley

(2016), Vol. 5, pp. 807-822, Molecular metabolism, Amsterdam, The Netherlands, C1

journal

Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell reports, New York, N.Y., C1

journal
2015

Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

T Connor, S Martin, K Howlett, S McGee

(2015), Vol. 42, pp. 109-115, Clinical and Experimental Pharmacology and Physiology, England, London, C1

journal

N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

D Wright, T Renoir, Z Smith, A Frazier, P Francis, D Thorburn, S McGee, A Hannan, L Gray

(2015), Vol. 5, pp. 1-10, Translational psychiatry, New York, N. Y., C1

journal

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.

C Wilson, S Shalini, A Filipovska, T Richman, S Davies, S Martin, S McGee, J Puccini, A Nikolic, L Dorstyn, S Kumar

(2015), Vol. 6, pp. e1597-e1597, Cell Death and Disease, England, C1

journal

The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice

K Venardos, K De Jong, M Elkamie, T Connor, S McGee

(2015), Vol. 10, pp. 1-14, PLoS one, San Francisco, Calif., C1-1

journal

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1

journal

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

journal

Lipid abundance in zebrafish embryos is regulated by complementary actions of the endocannabinoid system and retinoic acid pathway

D Fraher, M Ellis, S Morrison, S McGee, A Ward, K Walder, Y Gibert

(2015), Vol. 156, pp. 3596-3609, Endocrinology, Bethesda, Md., C1

journal

3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages

S Morrison, S McGee

(2015), Vol. 4, pp. 295-302, Adipocyte, London, Eng., C1

journal
2014

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

Darren Henstridge, Clinton Bruce, Brian Drew, Kálmán Tory, Attila Kolonics, Emma Estevez, Jason Chung, Nadine Watson, Timothy Gardner, Robert Lee-Young, others

(2014), Vol. 63, pp. 1881-1894, Diabetes, C1

journal

Improved synthesis and structural reassignment of MC1568 : a class IIa selective HDAC inhibitor

C Fleming, T Ashton, V Gaur, S McGee, F Pfeffer

(2014), Vol. 57, pp. 1132-1135, Journal of medicinal chemistry, Washington, DC, C1

journal

Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

S Martin, S Morrison, N Konstantopoulos, S McGee

(2014), Vol. 3, pp. 408-418, Molecular metabolism, Amsterdam, Netherlands, C1

journal

Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury

D Williams, K Venardos, M Byrne, M Joshi, D Horlock, N Lam, P Gregorevic, S McGee, D Kaye

(2014), Vol. 9, pp. 1-11, PLoS one, San Francisco, CA, C1

journal

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

T Parmenter, M Kleinschmidt, K Kinross, S Bond, J Li, M Kaadige, A Rao, K Sheppard, W Hugo, G Pupo, R Pearson, S McGee, G Long, R Scolyer, H Rizos, R Lo, C Cullinane, D Ayer, A Ribas, R Johnstone, R Hicks, G McArthur

(2014), Vol. 4, pp. 423-433, Cancer Discovery, Philadelphia, PA, C1

journal

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

S McGee, C Swinton, S Morrison, V Gaur, D Campbell, S Jorgensen, B Kemp, K Baar, G Steinberg, M Hargreaves

(2014), Vol. 28, pp. 3384-3395, FASEB journal, Bethesda, MD, C1

journal

The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

S Martin, S McGee

(2014), Vol. 1840, pp. 1303-1312, Biochimica et biophysica acta, Amsterdam, The Netherlands, C1

journal
2013

Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals

K Vissing, S McGee, J Farup, T Kjolhede, M Vendelbo, N Jessen

(2013), Vol. 23, pp. 355-366, Scandinavian journal of medicine and science in sports, Malden, Mass., C1

journal

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

A Walker, S Burnett, K Hasebe, J McGillivray, L Gray, S McGee, K Walder, M Berk, S Tye

(2013), Vol. 242, pp. 76-83, Behavioural brain research, Amsterdam, The Netherlands, C1

journal

Effect of DHA and CoenzymeQ10 against A?- and zinc-induced mitochondrial dysfunction in human neuronal cells

N Sadli, C Barrow, S McGee, C Suphioglu

(2013), Vol. 32, pp. 243-252, Cellular physiology and biochemistry, Berlin, Germany, C1

journal

Metabolic profile analysis of zebrafish embryos

Y Gibert, S McGee, A Ward

(2013), Vol. 71, pp. 1-5, Journal of visualized experiments, Cambridge, Mass., C1

journal

Zinc Finger Nuclease mediated knockout of ADP dependent Glucokinase in Cancer cell lines: Effects on cell survival and Mitochondrial Oxidative Metabolism

S Richter, S Morrison, T Connor, J Su, C Print, R Roniums, S McGee, W Wilson

(2013), Vol. 8, pp. 1-17, PLOS One, San Francisco, CA, C1

journal

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

C Winbanks, J Chen, H Qian, Y Liu, B Bernardo, C Beyer, K Watt, R Thomson, T Connor, B Turner, J McMullen, L Larsson, S McGee, C Harrison, P Gregorevic

(2013), Vol. 203, pp. 345-357, The Journal of Cell Biology, New York, NY, C1

journal

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

W Sanchez, S McGee, T Connor, B Mottram, A Wilkinson, J Whitehead, S Vuckovic, L Catley

(2013), Vol. 108, pp. 1624-1633, British journal of cancer, London, England, C1

journal

Skeletal muscle fat metabolism after exercise in humans: influence of fat availability

N Kimber, D Cameron-Smith, S McGee, M Hargreaves

(2013), Vol. 114, pp. 1577-1585, Journal of Applied Physiology, Bethesda, Md., C1

journal

Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling

M Fernandez-Rojo, M Gongora, R Fitzsimmons, N Martel, S Martin, S Nixon, A Brooks, M Ikonomopoulou, S Martin, H Lo, S Myers, C Restall, C Ferguson, P Pilch, S McGee, R Anderson, M Waters, J Hancock, S Grimmond, G Muscat, R Parton

(2013), Vol. 4, pp. 238-247, Cell Reports, Cambridge, MA, C1

journal
2012

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo

N Konstantopoulos, J Molero, S McGee, B Spolding, T Connor, M de Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, V Foletta, G Krippner, S Andrikopoulos, K Walder

(2012), Vol. 61, pp. 2146-2154, Diabetes, Alexandria, Va., C1

journal

Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

S Raichur, S Hooi-Teh, K Ohwaki, V Gaur, Y Long, M Hargreaves, S McGee, J Kusunoki

(2012), Vol. 49, pp. 203-211, Journal of molecular endocrinology, Bristol, England, C1

journal

Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat

R Teperino, S Amann, M Bayer, S McGee, A Loipetzberger, T Connor, C Jaeger, B Kammerer, L Winter, G Wiche, K Dalgaard, M Selvaraj, M Gaster, R Lee-Young, M Febbraio, C Knauf, P Cani, F Aberger, J Penniger, J Pospisilik, H Esterbauer

(2012), Vol. 151, pp. 414-426, Cell, Cambridge, Mass., C1

journal

Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism : implications for liver regeneration

M Fernandez-Rojo, C Restall, C Ferguson, N Martel, S Martin, M Bosch, A Kassan, G Leong, S Martin, S McGee, G Muscat, R Anderson, C Enrich, A Pol, R Parton

(2012), Vol. 55, pp. 1574-1584, Hepatology, Hoboken, N. J., C1

journal

Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes

S Hussey, S McGee, A Garnham, G McConell, M Hargreaves

(2012), Vol. 14, pp. 768-771, Diabetes, obesity and metabolism, Oxford, England, C1

journal
2011

DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

S McGee, N Sadli, S Morrison, C Swinton, C Suphioglu

(2011), Vol. 28, pp. 157-162, Cellular physiology and biochemistry, Basel, Switzerland, C1

journal

Histone modifications and exercise adaptations

S McGee, M Hargreaves

(2011), Vol. 110, pp. 258-263, Journal of applied physiology, Bethesda, Md., C1

journal

Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes

S Hussey, S McGee, A Garnham, J Wentworth, A Jeukendrup, M Hargreaves

(2011), Vol. 13, pp. 959-962, Diabetes, obesity and metabolism, West Sussex, England, C1-1

journal
2010

Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen

W Yeo, S McGee, A Carey, C Paton, A Garnham, M Hargreaves, J Hawley

(2010), Vol. 95, pp. 351-358, Experimental physiology, Oxford, England, C1

journal

AMPK-mediated transcription in skeletal muscle

S McGee, M Hargreaves

(2010), Vol. 118, pp. 507-518, Clinical science, London, England, C1

journal

Histone modifications and skeletal muscle metabolic gene expression

S McGee, M Hargreaves

(2010), Vol. 37, pp. 392-396, Clinical and experimental pharmacology and physiology, Richmond, Vic., C1

journal
2009

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1? in human skeletal muscle

M Gibala, S McGee, A Garnham, K Howlett, R Snow, M Hargreaves

(2009), Vol. 106, pp. 929-934, Journal of applied physiology, Bethesda, Md., C1

journal

Signalling GLUTtony keeps the sugar coming through glucose transporter expression

S McGee

(2009), Vol. 587, pp. 4133-4134, Journal of physiology, Oxford, England, C1

journal

Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations

J Ryu, J Drain, J Kim, S McGee, A Gray-Weale, L Waddington, G Parker, M Hargreaves, S Yoo, D Stapleton

(2009), Vol. 45, pp. 478-482, International journal of biological macromolecules, Amsterdam, Netherlands, C1

journal

Exercise-induced histone modifications in human skeletal muscle

S McGee, E Fairlie, A Garnham, M Hargreaves

(2009), Vol. 587, pp. 5951-5958, Journal of physiology, Oxford, England, C1

journal
2008

AMPK and transcriptional regulation

S McGee, M Hargreaves

(2008), Vol. 13, pp. 3022-3033, Frontiers in bioscience, Albertson, NY, C1-1

journal

Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

K Burgomaster, K Howarth, S Phillips, M Rakobowchuck, M MacDonald, S McGee, M Gibala

(2008), Vol. 586, pp. 151-160, Journal of physiology, Oxford, England, C1-1

journal

Effect of sex differences on human MEF2 regulation during endurance exercise

K Vissing, S McGee, C Roepstorff, P Scherling, M Hargreaves, B Kiens

(2008), Vol. 294, pp. 408-415, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

journal

Metabolic adaptations to short-term high-intensity interval training : a little pain for a lot of gain?

M Gibala, S McGee

(2008), Vol. 36, pp. 58-63, Exercise and sport sciences reviews, Philadelphia, Pa., C1-1

journal

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

S McGee, B van Denderen, K Howlett, J Mollica, J Schertzer, B Kemp, M Hargreaves

(2008), Vol. 57, pp. 860-867, Diabetes, Alexandria, Va., C1-1

journal

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase ?1 following overload in LKB1 knockout mice

S McGee, K Mustard, D Hardie, K Baar

(2008), Vol. 586, pp. 1731-1741, Journal of physiology, Oxford, England, C1-1

journal

Optimizing training adaptations by manipulating glycogen

K Baar, S McGee

(2008), Vol. 8, pp. 97-106, European journal of sport science, Abingdon, England, C1-1

journal

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

H Boon, M Bosselaar, S Praet, E Blaak, W Saris, A Wagenmakers, S McGee, C Tack, P Smits, M Hargreaves, L van Loon

(2008), Vol. 51, pp. 1893-1900, Diabetologia, Heidelberg, Germany, C1-1

journal
2007

Exercise and MEF2-HDAC interactions.

S McGee

(2007), Vol. 32, pp. 852-856, Applied physiology, nutrition and metabolism, Ottawa, Ontario, C1-1

journal
2006

Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle

S McGee, D Sparling, A Olson, M Hargreaves

(2006), Vol. 20, pp. 348-349, FASEB journal, Bethesada, Md., C1-1

journal

Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms

S McGee, M Hargreaves

(2006), Vol. 33, pp. 395-399, Clinical and experimental pharmacology and physiology, Richmond, Vic., C1-1

journal

Reduced glycogen availability is associated with increased AMPK?2 activity, nuclear AMPK?2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

G Steinberg, M Watt, S McGee, S Chan, M Hargreaves, M Febbraio, D Stapleton, B Kemp

(2006), Vol. 31, pp. 302-312, Applied physiology, nutrition, and metabolism, Ottawa, Ont., C1-1

journal
2005

Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression

L Cluberton, S McGee, R Murphy, M Hargreaves

(2005), Vol. 99, pp. 1359-1363, Journal of applied physiology, [Bethesda, Md.], C1-1

journal
2004

Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle

S McGee, M Hargreaves

(2004), Vol. 53, pp. 1208-1214, Diabetes, New York, N.Y., C1

journal

Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL-6 gene transcription during contraction

M Chan, S McGee, M Watt, M Hargreaves, M Febbraio

(2004), Vol. September, pp. 1-16, FASEB Journal, Bethesda, MD, C1

journal
2003

Exercise increases nuclear AMPK ?2 in human skeletal muscle

S McGee, K Howlett, R Starkie, D Cameron-Smith, B Kemp, M Hargreaves

(2003), Vol. 52, pp. 926-928, Diabetes, Alexandria, Va., C1

journal

Funded Projects at Deakin

Australian Competitive Grants

HDAC inhibition as an exercise mimetic and treatment for obesity and type 2 diabetes

A/Prof Sean Mcgee

DART Fellowship - Viertel Postdoctoral Fellowship in Diabetes - Diabetes Australia - Victoria (Research Trust)

  • 2011: $75,000
  • 2010: $150,000
  • 2009: $75,000

Molecular mechanisms regulating contraction-induced metabolic gene expression

A/Prof Sean Mcgee

NHMRC - Training PD Award - Peter Doherty Fellowship

  • 2009: $71,250

Activation of HSP72 in skeletal muscle as a therapeutic target for obesity

Prof Mark Febbraio, A/Prof Clinton Bruce, A/Prof Sean Mcgee, Prof Mark Hargreaves

NHMRC Project Grant

  • 2013: $20,000
  • 2012: $20,000

The role of amyloid beta in insulin resistance

A/Prof Sean Mcgee, Prof Ken Walder, Prof Mark Hargreaves

NHMRC Project Grant

  • 2014: $125,826
  • 2013: $138,472
  • 2012: $136,023

Understanding the role of class IIa histone deacetylases in metabolic disease

A/Prof Sean Mcgee, Prof Ken Walder

NHMRC Project Grant

  • 2014: $164,086
  • 2013: $161,714
  • 2012: $143,600

Targeting the class IIa histone deacetylases in metabolic disease

A/Prof Sean Mcgee

NHMRC CDF - Career Development Fellowship

  • 2015: $104,794
  • 2014: $102,941
  • 2013: $101,220
  • 2012: $99,431

Transforming fat to increase energy expenditure

A/Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2013: $59,312

Targeting protein kinase D to treat diabetic cardiomyopathy

A/Prof Sean Mcgee, Dr Kylie Vernados

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $58,592

Targeting class IIa histone deacetylases to impair breast cancer cell metabolism and survival

A/Prof Sean Mcgee

National Breast Cancer Foundation Innovator Grant

  • 2016: $97,690
  • 2015: $98,690

The role of GAPDH acetylation in the regulation of liver metabolism

A/Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2016: $59,983

The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

A/Prof Sean Mcgee, A/Prof Clinton Bruce, Prof Forest White, Prof Ken Walder

NHMRC Project Grant

  • 2017: $141,023

The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy

A/Prof Sean Mcgee, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2017: $59,962

Industry and Other Funding

Proliferation and cell cycle arrest by AMP-activated protein kinase and histone deacetylase 5

A/Prof Sean Mcgee

  • 2009: $9,370

Mechanistically linking type 2 diabetes and Alzheimer's disease

A/Prof Sean Mcgee

  • 2012: $74,290

HDAC Inhibition as a Potential Therapy for Preventing the Progression of Type 2 Diabetes

Dr Kathryn Aston-Mourney, A/Prof Sean Mcgee

  • 2015: $55,000

Identifying the role of altered mitochondrial metabolism in malignant rhabdoid tumours and evaluating potential epigenetic therapies

Prof David Ashley, A/Prof Sean Mcgee, Dr Jason Cain

  • 2016: $23,000

Supervisions

Principal Supervisor
2016

Simon Bond

Thesis entitled: The Role of Glyceraldehyde-3-Phosphate Dehydrogenase Acetylation in Liver Metabolism

Doctor of Philosophy (Medicine), School of Medicine

2014

Vidhi Gaur

Thesis entitled: HDAC inhibition as a therapeutic potential to treat metabolic diseases

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2016

Corinna Pade

Thesis entitled: Dissecting the early entry steps of HIV-1 infection

Doctor of Philosophy (Medicine), School of Medicine

2015

Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine