Dr Steve Cheung

STAFF PROFILE

Position

Senior Lecturer In Biomedical Science

Faculty

Faculty of Sci Eng & Built Env

Department

School of Life & Env. Sciences

Campus

Melbourne Burwood Campus

Contact

steve.cheung@deakin.edu.au
+61 3 924 46110

Biography

Dr Cheung obtained his Ph.D. in 1993 from the University of Melbourne. His postdoctoral studies were undertaken at Monash University. He began his teaching career (2001-2007) at the National University of Singapore. On his return to Australia he joined the Menzies Research Institute as a Principal Research Fellow, and then joined Deakin University in 2011 (June) as an academic teaching staff. He has published over 75 peer-reviewed articles and achieved >2400 total career citations with h-index of 27. His research is currently supported by NH&MRC. Dr Cheung’s research interests centre on the brain injury mechanisms and the identification of novel genes involved in chronic neurodegeneration. Since 2003 his research group has continued to use microarray and proteomics to search for molecular markers and cellular signalling pathways that may be useful therapeutically in neurological diseases. Currently his group is investigating the role of cell cycle-associated protein kinase in excitotoxic neuronal death. Targeted gene delivery into primary cerebral cortical neurons using lentiviral vector mediated overexpression studies is employed in this study.

Read more on Steve's profile

Units taught

SLE321 Molecular Biology Techniques
SLE323 Advanced Topics in Biomedical Science

Knowledge areas

Cell and Molecular Biology of neuronal cell death
Microarray and proteomics

Awards

Recipient of 2014 Deakin University Award for Teaching Excellence.

Projects

The role of cell cycle-associated protein kinase in stroke and traumatic brain injury.
Molecular mechanisms of neuronal death in Niemann–Pick disease type C.

Publications

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2016

Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway

Ms Yann Yap, Dr Roxana Llanos, Dr Sharon La Fontaine, Dr Michael Cater, Prof Philip Beart, Dr Steve Cheung

(2016), Vol. 41, pp. 554-567, Neurochemical research, New York, N.Y., C1

journal
2013

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity

M. Iqbal Hossain, Carli L. Roulston, M. Aizuddin Kamaruddin, Percy W. Y. Chu, Dominic C. H. Ng, G. J. Dusting, Jeffrey D. Bjorge, Nicholas A. Williamson, Donald J. Fujita, Dr Steve Cheung, Tung O Chan, Andrew F. Hill, Dr Heung Cheng

(2013), Vol. 288, pp. 9696-9709, Journal of biological chemistry, Bethesda, Md., C1

journal

Gene profiling identifies commonalities in neuronal pathways in excitotoxicity : evidence favouring cell cycle re-activation in concert with oxidative stress

Minghui Jessica Chen, Jian Ming Jeremy Ng, Zhao Feng Peng, Jayapal Manikandan, Ms Yann Yap, Dr Roxana Llanos, Prof Philip Beart, Dr Steve Cheung

(2013), Vol. 62, pp. 719-730, Neurochemistry international, Amsterdam, The Netherlands, C1

journal

Gene expression profiling of rotenone-mediated cortical neuronal death : evidence for inhibition of ubiquitin–proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling

Ms Yann Yap, Minghui Jessica Chen, Zhao Feng Peng, Jayapal Manikandan, Jian Ming Jeremy Ng, Dr Roxana Llanos, Dr Sharon La Fontaine, Prof Philip Beart, Dr Steve Cheung

(2013), Vol. 62, pp. 653-663, Neurochemistry international, Amsterdam, The Netherlands, C1

journal
2012

Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades

Zhao Feng Peng, Minghui Jessica Chen, Jayapal Manikandan, Alirio Melendez, Guanghou Shui, Francoise Russo-Marie, Matthew Whiteman, Prof Philip Beart, Philip K. Moore, Dr Steve Cheung

(2012), Vol. 16, pp. 41-58, Journal of cellular and molecular medicine, Oxford, England, C1

journal

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro

Jian Ming Jeremy Ng, Minghui Jessica Chen, Jacqueline Y. K. Leung, Zhao Feng Peng, Jayapal Manikandan, Robert Z. Qi, Meng Inn Chuah, Adrian K. West, James C. Vickers, Jia Lu, Dr Steve Cheung, Roger S. Chung

(2012), Vol. 16, pp. 789-811, Journal of cellular and molecular medicine, Oxford, England, C1

journal

Impaired insulin signaling in an animal model of Niemann-Pick type C disease

Qi-Rui Ong, Mei-Li Lim, Ching-Ching Chua, Dr Steve Cheung, Boon Seng Wong

(2012), Vol. 424, pp. 482-487, Biochemical and biophysical research communications, Philadelphia, Pa., C1

journal

Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor Fasudil reveals cytoskeletal and pro-survival responses

Chew L. Lau, Victoria M. Perreau, Minghui Jessica Chen, Holly S. Cate, Daniel Merolo, Dr Steve Cheung, Ross D. O'Shea, Prof Philip Beart

(2012), Vol. 227, pp. 1199-1211, Journal of cellular physiology, London, England, C1-1

journal

Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice

Li-Min Chua, Mei-Li Lim, Pey-Rou Chong, Ze-Ping Hu, Dr Steve Cheung, Boon Seng Wong

(2012), Vol. 29, pp. 783-791, Journal of alzheimer's disease, Amsterdam, The Netherlands, C1

journal
2011

Gene profiling reveals hydrogen sulphide recruits death signaling via the N-methyl-D-aspartate receptor identifying commonalities with excitotoxicity

Minghui Jessica Chen, Zhao Feng Peng, Jayapal Manikandan, Alirio Melendez, Gek San Tan, Ching Ming Chung, A/Prof Qiu Tian Li, Theresa May Chin Tan, Lih Wen Deng, Matthew Whiteman, Prof Philip Beart, Philip K. Moore, Dr Steve Cheung

(2011), Vol. 226, pp. 1308-1322, Journal of cellular physiology, Hoboken, United States, C1-1

journal

The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein

Lisheng He, Zhaojun Zhang, Yan Yu, Sohail Ahmed, Dr Steve Cheung, Robert Z. Qi

(2011), Vol. 68, pp. 1633-1643, Cellular and molecular life sciences, Basel, Switzerland, C1-1

journal

Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin

Meng Shyan Choy, Minghui Jessica Chen, Jayapal Manikandan, Zhao Feng Peng, Andrew M. Jenner, Alirio Melendez, Dr Steve Cheung

(2011), Vol. 226, pp. 494-510, Journal of cellular physiology, Hoboken, N. J., C1-1

journal

A global transcriptomic view of the multifaceted role of glutathione peroxidase-1 in cerebral ischemic-reperfusion injury

Minghui Jessica Chen, Connie H. Y. Wong, Zhao Feng Peng, Jayapal Manikandan, Alirio Melendez, Theresa May Chin Tan, Peter J. Crack, Dr Steve Cheung

(2011), Vol. 50, pp. 736-748, Free radical biology and medicine, Philadelphia, Pa., C1

journal
2010

Oxidative stress : emerging mitochondrial and cellular themes and variations in neuronal injury

G. C. Higgins, Prof Philip Beart, Y. S. Shin, Minghui Jessica Chen, Dr Steve Cheung, Phillip Nagley

(2010), Vol. 20, pp. 453-473, Journal of alzheimer's disease, Amsterdam, Netherlands, C1-1

journal

Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator

Jenny Chew, Minghui Jessica Chen, Alan Yiu-Wah Lee, Zhao Feng Peng, Kevin Wai Yin Chong, Lisheng He, Boon-Huat Bay, Jian Ming Jeremy Ng, Robert Z. Qi, Dr Steve Cheung

(2010), Vol. 111, pp. 1359-1366, Journal of cellular biochemistry, Hoboken N.J., C1-1

journal

Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury

Kevin Wai Yin Chong, Minghui Jessica Chen, Evelyn Siew-Chuan Koay, Boon Seng Wong, Alan Yiu-Wah Lee, Francoise Russo-Marie, Dr Steve Cheung

(2010), Vol. 485, pp. 129-133, Neuroscience letters, Shannon, Ireland, C1-1

journal

Temporal transcriptomic profiling reveals cellular targets that govern survival in HOCl-mediated neuronal apoptosis

Ms Yann Yap, Minghui Jessica Chen, Meng Shyan Choy, Zhao Feng Peng, Matthew Whiteman, Jayapal Manikandan, Alirio Melendez, Dr Steve Cheung

(2010), Vol. 87, pp. 457-467, Life sciences, Philadelphia, Pa., C1-1

journal
2009

GSK3β modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner

Weishi Zhang, Adam Smith, A/Prof Jun-Ping Liu, Dr Steve Cheung, Shu-Feng Zhou, Ke Liu, A/Prof Qiu Tian Li, Prof Wei Duan

(2009), Vol. 21, pp. 237-245, Cellular signalling, Amsterdam, The Netherlands, C1

journal
2008

Neuroprotective and pro-apoptotic responses of ubiquitin proteasome system

Meng Shyan Choy, Dr Steve Cheung

(2008), pp. 579-598, The ubiquitin proteasome system in the central nervous system : from physiology to pathology, New York, N.Y., B1-1

chapter

Water and ion channels : crucial in the initiation and progression of apoptosis in central nervous system?

Minghui Jessica Chen, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Meng Shyan Choy, Jayapal Manikandan, Alirio Melendez, Kandiah Jeyaseelan, Dr Steve Cheung

(2008), Vol. 6, pp. 102-116, Current neuropharmacology, Bussum, Netherlands, C1-1

journal

Proteasome inhibition : an early or late event in nitric oxide-induced neuronal death?

Zhao Feng Peng, Minghui Jessica Chen, Ms Yann Yap, Jayapal Manikandan, Alirio Melendez, Meng Shyan Choy, Philip K. Moore, Dr Steve Cheung

(2008), Vol. 18, pp. 136-145, Nitric oxide : biology and chemistry, Maryland Heights, Mo., C1-1

journal

Antioxidants : promising neuroprotection against cardiotoxin-4b-induced cell death which triggers oxidative stress with early calpain activation

Tan Boon Tan, Minghui Jessica Chen, Arunmozhiarasi Armugam, Feng Peng Peng, A/Prof Qiu Tian Li, Kandiah Jeyaseelan, Dr Steve Cheung

(2008), Vol. 51, pp. 964-973, Toxicon, Oxford, England, C1-1

journal
2007

Sulfatide-tenascin interaction mediates binding to the extracellular matrix and endocytic uptake of liposomes in glioma cells

Ke Shao, Qingsong Hou, Mei Lin Go, Prof Wei Duan, Dr Steve Cheung, S Feng, Kim Ping Wong, A Yoram, Weishi Zhang, Zhili Huang, A/Prof Qiu Tian Li

(2007), Vol. 64, pp. 506-515, Cellular and molecular life sciences, Basel, Switzerland, C1

journal

Pituitary adenylate cyclase-activating polypeptide induces translocation of its G-protein-coupled receptor into caveolin-enriched membrane microdomains, leading to enhanced cyclic AMP generation and neurite outgrowth in PC12 cells

Weishi Zhang, Prof Wei Duan, Dr Steve Cheung, Zhili Huang, Ke Shao, A/Prof Qiu Tian Li

(2007), Vol. 103, pp. 1157-1167, Journal of neurochemistry, Chichester, England, C1

journal

Hierarchical recruitment by AMPA but not staurosporine of proapoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk

Prof Philip Beart, Maria L. R. Lim, Baohong Chen, Shanti Diwakarla, Linda D. Mercer, Dr Steve Cheung, Phillip Nagley

(2007), Vol. 103, pp. 2408-2427, Journal of neurochemistry, Oxford, England, C1-1

journal

Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons

Dr Steve Cheung, Zhao Feng Peng, Minghui Jessica Chen, Philip K. Moore, Matthew Whiteman

(2007), Vol. 53, pp. 505-514, Neuropharmacology, Oxford, England, C1-1

journal

The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways

Matthew Whiteman, Siew Hwa Chu, Jia Ling Siau, Peter Rose, Kanaga Sabapathy, Jan-Thorsten Schantz, Dr Steve Cheung, Jeremy P E Spencer, Jeffrey S. Armstrong

(2007), Vol. 19, pp. 705-714, Cellular signalling, Philadelphia, Pa., C1-1

journal

Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport : microarray and proteomics analyses in cultured murine cortical neurons

Chor Hui Vivien Koh, Zhao Feng Peng, Keli Ou, Alirio Melendez, Jayapal Manikandan, Robert Z. Qi, Dr Steve Cheung

(2007), Vol. 211, pp. 63-87, Journal of cellular physiology, Hoboken N.J., C1-1

journal

Chlorinative stress : an under appreciated mediator of neurodegeneration?

Ms Yann Yap, Matthew Whiteman, Dr Steve Cheung

(2007), Vol. 19, pp. 219-228, Cellular signalling, Philadelphia, Pa., C1-1

journal

Microtubule association of the neuronal p35 activator of Cdk5

Zhibo Hou, Qing Li, Lisheng He, Hui-Ying Lim, Xinrong Fu, Dr Steve Cheung, Donna X. Qi, Robert Z. Qi

(2007), Vol. 282, pp. 18666-18670, Journal of biological chemistry, Bethesda, Md., C1-1

journal

Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons : transcriptional responses and cellular pathways

Zhao Feng Peng, Chor Hui Vivien Koh, A/Prof Qiu Tian Li, Jayapal Manikandan, Alirio Melendez, Soon Yew Tang, Barry Halliwell, Dr Steve Cheung

(2007), Vol. 53, pp. 687-698, Neuropharmacology, Oxford, England, C1-1

journal
2006

The very C-terminus of protein kinase CĹ is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1

Yimin Zhu, Derek Smith, Chandra Verma, Wee Guan Lim, Bee Jen Tan, Jeffrey S. Armstrong, Shu-Feng Zhou, Eli Chan, Seng-Lai Tan, Yi-Zhun Zhu, Dr Steve Cheung, Prof Wei Duan

(2006), Vol. 18, pp. 807-818, Cellular signalling, Amsterdam, Netherlands, C1-1

journal

Early induction of chalpains in rotenone-mediated neuronal apoptosis

Minghui Jessica Chen, Ms Yann Yap, Meng Shyan Choy, Chor Hui Vivien Koh, Sze Jee Seet, Prof Wei Duan, Matthew Whiteman, Dr Steve Cheung

(2006), Vol. 397, pp. 69-73, Neuroscience letters, Limerick, Ireland, C1-1

journal

U18666A-mediated apoptosis in cultured murine cortical neurons : role of caspases, calpains and kinases

Chor Hui Vivien Koh, Robert Z. Qi, Dianbo Qu, Alirio Melendez, Jayapal Manikandan, Boon-Huat Bay, Prof Wei Duan, Dr Steve Cheung

(2006), Vol. 18, pp. 1572-1583, Cellular signalling, Amsterdam, Netherlands, C1-1

journal

The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Cá*

Sui Sum Yeong, Yimin Zhu, Derek Smith, Chandra Verma, Wee Guan Lim, Bee Jen Tan, A/Prof Qiu Tian Li, Dr Steve Cheung, Minnie Cai, Yi-Zhun Zhu, Shu-Feng Zhou, Seng-Lai Tan, Prof Wei Duan

(2006), Vol. 281, pp. 30768-30781, Journal of biological chemistry, Bethesda, Md, C1

journal

pH dependent high transfection efficiency of mouse neuroblastomas using TransFectin

Kevin Wai Yin Chong, Alan Yiu-Wah Lee, Evelyn Siew-Chuan Koay, Sze Jee Seet, Dr Steve Cheung

(2006), Vol. 158, pp. 56-63, Journal of neuroscience methods, Amsterdam, Netherlands, C1-1

journal

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis

Meng Shyan Choy, Boon-Huat Bay, Dr Heung Cheng, Dr Steve Cheung

(2006), Vol. 405, pp. 120-125, Neuroscience letters, Shannon, Ireland, C1-1

journal

Identification of nuclear import mechanisms for the neuronal Cdk5 activator

Xinrong Fu, Yuk-Kwan Choi, Dianbo Qu, Yan Yu, Dr Steve Cheung, Robert Z. Qi

(2006), Vol. 281, pp. 39014-39021, Journal of biological chemistry, Bethesda, Md., C1-1

journal

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes

Ms Yann Yap, Matthew Whiteman, Boon-Huat Bay, Yuhong Li, Fwu-Shan Sheu, Robert Z. Qi, Chee Hong Tan, Dr Steve Cheung

(2006), Vol. 98, pp. 1597-1609, Journal of neurochemistry, Oxford, London, C1-1

journal

Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons

Chor Hui Vivien Koh, Matthew Whiteman, Qiao-Xin Li, Barry Halliwell, Andrew M. Jenner, Boon Seng Wong, Katrina M. Laughton, Markus Wenk, C Masters, Prof Philip Beart, Ora Bernard, Dr Steve Cheung

(2006), Vol. 98, pp. 1278-1289, Journal of neurochemistry, Oxford, England, C1-1

journal

Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons : bridging Niemann–Pick disease type C and Alzheimer's disease

Chor Hui Vivien Koh, Dr Steve Cheung

(2006), Vol. 18, pp. 1844-1853, Cellular signalling, Philadelphia, Pa., C1-1

journal

Neuronal cell death caused by inhibition of intracellular cholesterol trafficking is caspase dependent and associated with activation of the mitochondrial apoptosis pathway

Zhili Huang, Qingsong Hou, Dr Steve Cheung, A/Prof Qiu Tian Li

(2006), Vol. 97, pp. 280-291, Journal of neurochemistry, Oxford, England, C1-1

journal

Overexpression of Aβ is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

Qiao-Xin Li, Su San Mok, Katrina M. Laughton, Catriona A. McLean, Irene Volitakis, Dr Robert Cherny, Dr Steve Cheung, Anthony White, C Masters

(2006), Vol. 5, pp. 153-165, Aging cell, Oxford, England, C1-1

journal
2005

Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses : a microarray analysis

Elaine Hau Jin Yew, Dr Steve Cheung, Meng Shyan Choy, Robert Z. Qi, Alan Yiu-Wah Lee, Zhao Feng Peng, Alirio Melendez, Jayapal Manikandan, Evelyn Siew-Chuan Koay, Lily-Lily Chiu, Wooi Loon Ng, Matthew Whiteman, Kandiah Jeyaseelan, Barry Halliwell

(2005), Vol. 94, pp. 943-956, Journal of neurochemistry, Oxford, England, C1-1

journal

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells : role of mitochondrial permeability transition

Matthew Whiteman, Peter Rose, Jia Ling Siau, Dr Steve Cheung, Gek San Tan, Barry Halliwell, Jeffrey S. Armstrong

(2005), Vol. 38, pp. 1571-1584, Free radical biology and medicine, Philadelphia, Pa., C1-1

journal

Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

Matthew Whiteman, Dr Steve Cheung, Yi-Zhun Zhu, Siew Hwa Chu, Jia Ling Siau, Boon Seng Wong, Jeffrey S. Armstrong, Philip K. Moore

(2005), Vol. 326, pp. 794-798, Biochemical and biophysical research communications, San Diego, Calif, C1-1

journal