Dr Torie Foletta



Research Fellow


Faculty of Health


School of Exercise & Nut. Sci.


Melbourne Burwood Campus


Research interests

Dr Foletta is interested in characterizing specific molecular factors connecting skeletal muscle growth and metabolism. She uses a variety of molecular and cell biological techniques, genomics, proteomics and bioinformatics to obtain overviews of the molecules and signaling pathways involved in healthy and diseased states of skeletal muscle. Some of her current research projects involve the molecules NDRG2, PGC-1, ERRalpha, and the E3 ligases, atrogin-1/MAFbx and MuRF1.


Australian Physiological Society
Australian Society for Medical Research

Teaching interests

Supervises 1 PhD student
Co-supervises 2 PhD students


Foletta VC, McGee SL, Russell, AP. NDRG2, a putative tumour suppressor, increases ROS production and alters oxidative metabolism following its suppression in muscle cells. Oral Presentation. AussieMit 2012, Melbourne, 2012.

Foletta VC, Brown EL, Russell AP. Suppression of NDRG2, a novel PGC-1??? target gene, contributes to the metabolic profile and protein synthesis rates of skeletal muscle cells.  Oral presentation. AuPS/ASB/PSNZ Meeting, Sydney, 2012.

Foletta VC, McGee SL, Brown EL, Russell AP. NDRG2, a new effector of PGC-1 function in the control of skeletal muscle mass and metabolism.
Invited Speaker. Exercise, Muscle & Metabolism, Melbourne, 2011.

Foletta VC, Russell AP. NDRG2, a novel player in the control of skeletal muscle mass? Oral presentation. AuPS/ASB Meeting, Adelaide, 2010.

Foletta  VC, Cameron-Smith D, Walder K, Russell A. N-myc downstream-regulated gene 2 interacts with atrogin-1. A novel role for NDRG2 in skeletal muscle atrophy?
Oral presentation. Gage Muscle Conference, Canberra, ACT, 2010.

Professional activities

Dr Foletta is a regular reviewer for Metabolism, Clinical and Experimental, Molecular and Cellular Endocrinology, and Nutrition and Metabolism


Fellows’ Award for Research Excellence, National Institutes of Health (NIH)
Fogarty Visiting Fellows’ Award, National Institutes of Health (NIH)


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Analysis of mammalian cell proliferation and macromolecule synthesis using deuterated water and gas chromatography-mass spectrometry.

Dr Torie Foletta, Michelle Palmieri, Joachim Kloehn, Mr Shaun Mason, Stephen Previs, Prof Malcolm McConville, Dr Oliver Sieber, A/Prof Clinton Bruce, Dr Greg Kowalski

(2016), Vol. 6, pp. 1-19, Metabolites, Basel, Switzerland, C1


NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide - but not palmitate-induced toxicity

Kimberley Anderson, Prof Aaron Russell, Dr Torie Foletta

(2015), Vol. 5, pp. 668-681, FEBS open bio, Amsterdam, The Netherlands, C1


Skeletal muscle mitochondria : a major player in exercise, health and disease.

Prof Aaron Russell, Dr Torie Foletta, Prof Rod Snow, A/Prof Glenn Wadley

(2014), Vol. 1840, pp. 1276-1284, Biochimica et Biophysica Acta - General Subjects, Amsterdam , Netherlands, C1


New gene targets of PGC-1α and ERRα co-regulation in C2C12 myotubes

Abena Nsiah-Sefaa, Miss Erin Brown, Prof Aaron Russell, Dr Torie Foletta

(2014), Vol. 41, pp. 8009-8017, Molecular biology reports, Amsterdam, The Netherlands, C1


Ndrg2 is a PGC-1cx/ERRcx target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes

Dr Torie Foletta, Miss Erin Brown, Yoshitake Cho, Prof Rod Snow, Anastasia Kralli, Prof Aaron Russell

(2013), Vol. 1833, pp. 3112-3123, Biochimica et Biophysica Acta - Molecular Cell Research, Amsterdam, Netherlands, C1


A gene expression signature for insulin resistance

Dr Nicky Konstantopoulos, Dr Torie Foletta, Dr David Segal, Kate Shields, Mr Andrew Sanigorski, Dr Kelly Windmill, Mrs Courtney Swinton, Mr Timothy Connor, Mr Stephen Wanyonyi, Thomas D Dyer, Mr Richard Fahey, Rose A. Watt, Joanne Curran, Dr Juan Carlos Molero-Navajas, Dr Guy Krippner, Prof Gregory Collier, Prof David E James, John Blangero, Dr Jeremy Jowett, Prof Ken Walder

(2011), Vol. 43, pp. 110-120, Physiological genomics, Bethesda, Md., C1


The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

Dr Torie Foletta, Lloyd J. White, Amy Larsen , Dr Bertrand Leger, Prof Aaron Russell

(2011), Vol. 461, pp. 325-335, Pfluegers Archiv: European journal of physiology, Heidelberg, Germany, C1


The characterisation of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome

Mr Matthew Prior, Dr Torie Foletta, Dr Jeremy Jowett, Dr David Segal, Melanie A. Carless, Joanne Curran, Thomas D Dyer, Eric K Moses, Andrew J. McAinch, Dr Nicky Konstantopoulos, Dr Kiymet Bozaoglu, Prof Gregory Collier, A/Prof David Cameron-Smith, John Blangero, Prof Ken Walder

(2010), Vol. 59, pp. 1057-1064, Metabolism, Philadelphia, Pa., C1


NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors

Dr Torie Foletta, Mr Matthew Prior, Dr Nicole Stupka, Dr Kate Carey (nee Mehan), Dr David Segal, Ms Sharon Jones, Mrs Courtney Swinton, Miss Sheree Martin, A/Prof David Cameron-Smith, Prof Ken Walder

(2009), Vol. 587, pp. 1619-1634, Journal of physiology, Oxford, England, C1


Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance

James Trevaskis, Prof Ken Walder, Dr Torie Foletta, Ms Lyndal Bayles, Dr Janine Mc Millan, Mr Adrian Cooper

(2005), Vol. 146, pp. 3757-3764, Endocrinology, Philadelphia, Pa., C1-1



No grants found


Principal Supervisor

Kimberley Catania

Thesis entitled: NDRG2 overexpression effects on skeletal muscle cell growth & stress-response

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Associate Supervisor

Renae Stefanetti

Thesis entitled: Atrogin-1 and MURF-1 signalling in human skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences


Erin Brown

Thesis entitled: The role of PGC-1a and PGC-1b in skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences


Matthew Prior

Thesis entitled: AHI-I and NDRG2 Function in Skeletal Muscle and the Development of Type 2 Diabetes

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences