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The major aim of Professor Snow's current research is to understand the regulation of muscle creatine content and creatine's role in muscle function in health and disease. Creatine is a molecule with an important role in cellular energy metabolism, especially when cells are under a metabolic stress induced by normal physiological disturbances, such as exercise or disease states.
Professor Snow's research focuses on mechanisms that regulate the expression and activity of the creatine transporter proteins responsible for the entry of creatine into skeletal muscle. His research is also investigating the role that creatine may play in regulating muscle gene expression in processes involved with signalling muscle enlargement or wasting.
Professor Daly’s research expertise and interests include: the role of exercise and nutrition for optimising musculoskeletal health and preventing chronic diseases such as osteoporosis and type 2 diabetes; the use of state-of-the-art non-invasive methods (MRI and QCT) for assessing body composition, bone strength and aortic calcification; and health issues related to vitamin D deficiency, low grade systemic inflammation and dietary protein in the elderly.
Research profileInvestigations are performed using human models of muscle wasting including amyotrophic lateral sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), ageing (sarcopenia) and immobilization. Acute and chronic resistance and endurance exercise protocols are used as models to investigate the signalling proteins which positively regulate skeletal muscle growth and regeneration. In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.
Associate Professor Russell's research is focused on determining the molecular factors that control muscle wasting, growth, regeneration and function. The eventual aim is to identify potential therapeutic strategies and pharmacological targets to reduce muscle wasting and enhance muscle growth and function.
Dr Wadley's research program has two major streams. The first stream examines the impacts of physical activity and the nutritional environments during early life on later adult health. A second research stream investigates the molecular mechanisms regulating skeletal muscle adaptations, particularly the regulation of mitochondrial biogenesis (synthesis) following exercise.
Both of these topics have important implications for the treatment and prevention of Type 2 diabetes and cardiovascular disease.
Dr Foletta's research is focused on key molecular pathways and proteins in skeletal muscle physiology. Understanding the molecular processes that underpin the physiology of skeletal muscle in healthy and diseased states will help to improve treatment outcomes and healthy ageing for individuals.