Mammosapiens: Comparative genome bioinformatics and bioinformatics of the lactation program.
Comparative Genome bioinformatics
Recently the genome sequences of a rapidly growing number of organisms have become available.
The comparisons of these genomes yield tremendous insights into the genes that are essential for life and those that define the species, revealing the mechanisms of evolution and the hidden mechanisms of gene regulation.
We are developing a high performance computational platform for the comparative analysis of genome sequences and the collection of genomic data sets for the analysis of bioinformation involved in the regulation of gene expression.
Mammosapiens: bioinformatics of the lactation program
Mammals are characterized by the total dependency of the new born on milk produced by the maternal mammary gland and lactation is one of the most remarkable products of evolution. The rich mammalian diversity found in Australia provides a unique resource to study the evolution of lactation.
Mammalian species have evolved a variety of lactation strategies. The Mammosapiens project is employing high throughput technology platform, including genomics, transcriptomics, proteomics, metabolomics and bioactivity screens, for the study of lactation in mammals with extreme lactation strategies. A bioinformatics resource is used to support storage and analysis of the data generated.
Future Research Directions
The current sequencing of over 85 vertebrate genomes will bring a large flow of sequence data for comparative analysis during the next few years.
Our challenge will be to develop high performance capacity for the computational analysis of the data and the reinforcement of partnerships with experimentalists focusing on particular systems (mammalian lactation, pigeon lactation, chicken development & miRNA biology, gene expression analysis).