Dr. Tye serves as the Unit Chair of Health Behaviour and is an active researcher in the School of Psychology. She investigates the neurobiological mechanisms mediating stress, depression and addiction, as well as the modulatory role of novel treatment strategies such as deep brain stimulation. An advocate for enhancement of youth health awareness and neuroscience-based education practices, Dr. Tye is also actively involved in determining gaps in youth health and mental health knowledge and rectifying these issues through development of educational resources and programs that promote health behaviours and a passion for lifelong learning.
Dr. Tye’s mental health neurobiology research program aims to determine the biological mechanisms by which stress hormones disrupt, and effective pharmacotherapies and neuromodulation technologies restore, neurotransmission in mental illness, particularly depression. To achieve this, Dr Tye utilises electrochemical recording techniques relatively novel to Australian neuroscience to monitor rapid synaptic neurotransmission in animal models of neuropsychiatric illness through assessment of:
Dr Tye is also keenly interested in translating recent medical and neuroscience research findings into relevant and engaging educational resources that serve as effective tools in improving health-related behavioural choices through enhanced learning opportunities. To achieve this, a complementary component of her research assesses the relative level of health and mental health awareness among Australian youth and the impact of educational programs on their current lifestyle choices.
Dr Tye works closely with world leaders in these fields through collaborative partnerships with the Mayo Clinic, University of Memphis, University of Illinois, Emory University, UNESCO and Macquarie University.
Awards and prizes
• National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (2009)
• American Australian Association Sir Keith Murdoch Fellow (2008)
• Mayo Clinic Postdoctoral Fellow (2008; 2009)
• Society for Neuroscience Travel Award (2008)
• Macquarie University Alumni Research Excellence Award (2008)
• Biological Sciences Health Awareness Research Grant (2008)
• Serono Pty Ltd Travel Award (2004)
• Bill Cantwell Prize (2004)
• Research Area and Centre for Excellence (RAACE) Award (2004)
Memberships
• Australian Society for Neuroscience
• Society for Neuroscience
• Addiction Neuroscience Network Australia
• Mayo Clinic Deep Brain Stimulation Consortium
Service to the University, discipline or community
Health Awareness and Lifestyle Choices school outreach program
Conferences
1. Tye SJ, Covey DP, Griessenauer CG, Garris PA, Lee KH. Catecholamine neurotransmission in the orbital frontal cortex evoked by stimulation of the ventral tegmental area. 39th Annual Meeting of the Society for Neuroscience. Chicago IL, USA. October 2009.
2. Griessenauer CJ, Chang S-Y, Tye SJ, Kimble CJ, Bennet K, Garris PA, Lee KH.WINCS-based wireless electrochemical monitoring of serotonin (5-HT) using fast-scan cyclic voltammetry: Proof of principle. 39th Annual Meeting of the Society for Neuroscience. Chicago IL, USA. October 2009.
3. Goerss SJ, Bledsoe JM, Covey DP, Griessenaur CJ, Tye SJ, Agnesi F, Blaha CD, Lee KH, Garris PA. The domestic pig as a large-animal model for brain chemical and bioelectrical microelectrode measurements and electrical stimulation. 39th Annual Meeting of the Society for Neuroscience. Chicago IL, USA. October 2009.
4. Chopra A, Matsumoto J, Lee K, Samspon S, Adams A, Tye S, Frye M. Comorbid Parkinson's disease and bipolar disorder: Levadopa abuse and mania and potential role of DBS in management. 8th International Conference on Bipolar Disorder Pittsburgh PA, USA. July 2009.
5. Tye SJ, Lee KH, Blaha CD. Short-term plasticity of phasic mesoaccumbens dopamine signal evoked by stimulation of the prefrontal cortex and ventral hippocampus is modulated by the glucocorticoid receptors in the ventral tegmentum. 38th Annual Meeting of the Society for Neuroscience. Washington DC, USA. November 2008.