Supervisor:
Associate Professor Wei DUAN, Ph.D., MBBS
School of Medicine
Deakin University, Waurn Ponds
Phone: 03 5227 1149. Email: wduan@deakin.edu.au

Projects available:
Course code for Ph.D. in School of Medicine is: H960

• Application of aptamer technology for molecular medicine
• Developing Molecularly targeted polymer nanoparticles for cancer therapeutics
• A novel tumour-targeted nanoliposome drug delivery system for the treatment of malignant gliomas
• Application of chemical biology in molecular therapeutics
• Development of isozyme-specific inhibitors of Akt/PKB
• Developing Isozyme-specific Inhibitors of novel class of protein kinase C
• Exploration of Chinese Medicine for the Management and Prevention of Type 2 Diabetes

Scholarship Top - up:
$6,000~ $12,000/annum will be provided to qualified applicants.

Funding sources of my research:
Federal Government, Department of Education, Science and Training;
Federal Government, Department of Health and Aging (National Health & Medical Research Council - NHMRC)

Techniques Employed:

• Molecular cloning, site-directed mutagenesis
• Protein engineering, directed in vitro protein kinase evolution
• Gene knock-in, tissue-specific gene knock-in
• Mammalian cell culture, 3-D cell culture
• Targeted drug delivery using polymer-based nanoparticles and nanoliposome
• Subcelluar biochemistry, ultracentrifugation, fast protein liquid chromatography
• Protein-Protein interaction, time-resolved fluorescence, fluorescence polarization
• Aptamer nano-technology, SELEX (Systematic Evolution of Ligands by Exponential Enrichment)
• Quantitative protein phosphorylation analysis, immune-complex kinase assay, liquid scintillation counting, phosphorimaging, multiplex phosphoprotein array
• High-throughput fluorescence aptamer-guided drug screening using robotic system