Immunohistochemistry is a technique used to detect, visualise and localise antigens within tissues.

Diaminobenzidine (DAB) reaction product (brown) counterstained with hematoxylin (blue)
In situ hybridisation
In situ hybridisation has become a powerful and versatile tool for the detection and localisation of nucleic acid sequences within cell or tissue preparations. The technique is capable of giving a high degree of spatial information to locate specific DNA or RNA sequences either within individual cells or chromosomes or to a small sub-population of cells within a tissue sample.
In situ hybridisation may be used to: