Prof Aaron Russell
|Position:||Associate Head Of School (Research)|
|Faculty or Division:||Faculty of Health|
|Department:||School of Exercise & Nut. Sci.|
|Campus:||Melbourne Burwood Campus|
|Phone:||+61 3 92517397 +61 3 92517397|
2011-present Associate Professor, School of Exercise and Nutrition Sciences, Deakin University
2011 Visist Research fellow, The Scripps Research inastitute, San Diego, USA
2008-2011 NHMRC Research Fellow, School of Exercise and Nutrition Sciences, Deakin University
2006-2008 Senior Lecturer, School of Exercise and Nutrition Sciences, Deakin University
2002-2006 Head Molecular Physiology, Clinique Romande de readaption, Sion Switzerland
2000-2002 Research Fellow, Department of Medical Biochemistry, University of Geneva, Switzerland
- Bachelor of Applied Science (Human Movement), Deakin University, 1995
- Doctor of Philosophy, Deakin University, 2001
- Graduate Certificate of Higher Education, Deakin University, 2008
Australia Physiological Society
Australian Society for Medical Research
Swiss Australian Academic Network
2012-present The International Scholarly Research Network –Physiology
2011-present Frontiers in Striated Muscle Physiology
2011-present World Journal of Translational Medicine
National Research Agency (France)
Australian Research Council
Health Research Board, (Ireland)
Diabetes Australia Research Trust
NHMRC Project Grants
The Italian Telethon Grant (Italy)
Wellcome Trust (UK)
HSE303 Exercise Metabolism
HBS400 – Honours pratical training
Supervised 6 Honours students to completion (all recieving H1 grades with a Scholarship)
Supervised 5 PhD students to completion
Conferences and seminars
(Invited presentation - past 5 years)
2013 Australian Physiological Society Conference (AuPS), Geelong; PGC-1α and ERRα control of muscle growth.
2013 Australian and New Zealand Obesity Society, Melbourne; microRNA control of brown adipose tissue.
2012 AussieMit - Australian Mitochondria Conference, Melbourne; microRNA¬???23a inhibits PGC-¬1α translation: a new regulator of mitochondrial biogenesis with exercise and disease.
2012 Australian Physiological Society Conference (AuPS), Sydney; Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis.
2010 European Muscle Conference, Padova, Italy; PGC-1α/β increase protein synthesis in C2C12 myotubes.
2012 The Gage Muscle Conference, Canberra; STARS as a potential mediator of skeletal muscle growth, regeneration and function.
2010 The Gage- Curtain Muscle Conference, Canberra Australia. PGC-1α regulates protein synthesis and growth related microRNAs: a potential target for combating muscle wasting.
2008 Australian Physiological Society Conference (AuPS), Melbourne. Molecular mechanisms regulating muscle mass.
2008 3rd Australian Association for Exercise and Sports Science (AAESS) Conference, Melbourne; Molecular Modelling of Muscle Mass.
2013 Macquarie University, Australia School of Advanced Medicine, Sydney; Identifying targets to treat amyotrophic lateral sclerosis.
2012 Nestle Research Centre, Lausanne, Switzerland. From cell biology to human physiology: a multidisciplinary approach to maintain health throughout the life span.
2011 Brock University, St Catherines, Canada; Novel roles and regulators of PGC-1α: implications for skeletal muscle health.
2011 The Scripps Research Institute, San Diego, USA; Identifying miRNAs involved in the differentiation of skeletal muscle-derived CD34+ cells into brown adipocytes.
2010 Dairy Health and Nutrition Consortium Muscle Maintenance Summit. Molecular factors controlling skeletal muscle wasting, growth and regeneration.
2009 Monash University, Department of Physiology Seminar Series; Regulation of skeletal muscle mass: influence of PGC-1α.
Awards and prizes
2009 Deakin University Award for Research Excellence
2008 - NHMRC Biomedical Career Development Award. Molecular
targets involved in human muscle atrophy and hypertrophy.
2003 - Best oral presentation.3rd Swiss Interfaculty Conference of Sport and Health, November 2003, Lausanne, Switzerland. Endurance training in humans leads to fibre type-specific increases in skeletal muscle αlevels of PGC-1α and PPAR.
Role and regulation of STARS signaling in skeletal uscle health; exercise, ageing and muscular dystrophies.
miRNA regulation of muscle adapation to exercise and disease.
The role of miRNAs in age-related mucsle wasting (sarcopenia).
PGC-1alph and beta as regulators of muscle growth and repair.
My research group is focused on determining the molecular factors that control skeletal muscle wasting, growth and regeneration. Investigations are performed humans using in vivo models of muscle wasting including motor neuron disease, DMD and sarcopenia. Acute and chronic exercise protocols are used as models to investigate the signalling proteins which regulate skeletal muscle growth and regeneration.
- In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.
- In vivo rodent models are used to investigate the role of specific molecular targets using AAV technology.
- Research tools include quantitative PCR, Western blotting, EMSA, Luciferase reporter assays, protein degradation and synthesis assays, glucose uptake assays, adenoviral.
- Infections and ChIP, in vivo protein synthesis (human muscle).
- Molecular targets of interest include PGC-1, STARS and several miRNA species.