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A/Prof. Chris Shaw

STAFF PROFILE

Position

Associate Professor

Faculty

Faculty of Health

Department

School of Exer & Nutr Sciences

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy, University of Birmingham, 2008

Contact

chris.shaw@deakin.edu.au
+61 3 522 73394

Biography summary

2014-present. Senior Lecturer, School of Exercise and Nutrition Sciences, Deakin University.

2012-2014. Senior Research Fellow, Institute of Sport, Exercise and Active Living, Victoria University.

2008-2012. Research Fellow, School of Sport and Exercise Sciences, University of Birmingham, UK. 

Research interests

Research Interests

Chris' research focuses on how lipid droplet metabolism influences insulin action in skeletal muscle and how exercise interventions can improve metabolic health. In particular, he has expertise in developing immunofluorescence microscopy techniques to study glucose and lipid metabolism in skeletal muscle.

Current Research Projects

The influence of muscle lipid metabolism on insulin sensitivity

Adaptations in muscle lipid droplets in response exercise training 

High intensity interval training and metabolic health

Affiliations

Accredited Exercise Physiologist, Exercise and Sports Science Australia

Australian Physiological Society

American Physiological Society

European College of Sports Science

Teaching interests

Undergraduate

HSE201: Exercise Physiology

HSE304: Physiology of Sports Performance

HSE303: Exercise Metabolism

Supervision of honours students

Postgraduate

Supervised 6 PhD students to completion

Conferences

Invited Presentations

Physiological and Metabolic Adaptations to High Intensity Interval Training. Melbourne Muscle Meeting, University of Melbourne, 2015.

High intensity interval training and lipid metabolism. Australian Physiological Society, Geelong 2013.

Exercise interventions, muscle lipids and insulin sensitivity. Victorian Obesity Consortium, Melbourne, 2013.

Lipid proteins and the regulation of muscle lipid metabolism. Lipotoxicity Symposium, University of Lausanne, Switzerland, 2012.

Exercise interventions to enhance intramuscular lipid metabolism and insulin sensitivity. 17th Annual Congress of the European College of Sports Science, Bruges, 2012.

Nutritional strategies to enhance endurance training adaptations. III International Seminar of Sports Nutrition, Porto, 2010.

Carbohydrate availability and training adaptation. Sports nutrition: what’s new? BASES, Glasgow. September 2010.

Fat metabolism during exercise: training and nutrition. II International Seminar of Sports Nutrition, Porto, March 2010.

Immunofluorescence microscopy to investigate the link between fat metabolism and insulin action. 14th Annual Congress of the European College of Sports Science, Oslo, 2009.

Publications

Filter by

2023

Intramuscular lipid utilization during exercise: a systematic review, meta-analysis, and meta-regression

J Stokie, G Abbott, K Howlett, D Hamilton, C Shaw

(2023), Vol. 134, pp. 581-592, Journal of Applied Physiology, Bethesda, Md., C1

journal article

A randomised controlled trial assessing the potential of palmitoylethanolamide (PEA) to act as an adjuvant to resistance training in healthy adults: a study protocol

Z Huschtscha, J Fyfe, S Feros, A Betik, C Shaw, L Main, G Abbott, S Tan, M Refalo, M Gerhardy, E Grunwald, A May, J Silver, C Smith, M White, D Hamilton

(2023), Vol. 24, Trials, C1

journal article

Autophagy and exercise: Current insights and future research directions

J Botella, C Shaw, D Bishop

(2023), pp. 1-12, International Journal of Sports Medicine, Berlin, Germany, C1

journal article
2022

Muscle fiber type-specific autophagy responses following an overnight fast and mixed meal ingestion in human skeletal muscle

M Morales-Scholz, S Wette, J Stokie, B Tepper, C Swinton, D Hamilton, K Dwyer, R Murphy, K Howlett, C Shaw

(2022), Vol. 323, pp. E242-E253, American Journal of Physiology - Endocrinology and Metabolism, United States, C1

journal article
2021

Prior exercise enhances skeletal muscle microvascular blood flow and mitigates microvascular flow impairments induced by a high-glucose mixed meal in healthy young men

L Parker, D Morrison, G Wadley, C Shaw, A Betik, K Roberts-Thomson, G Kaur, M Keske

(2021), Vol. 599, pp. 83-102, Journal of Physiology, England, C1

journal article

Autophagy is not involved in lipid accumulation and the development of insulin resistance in skeletal muscle

María Morales-Scholz, Courtney Swinton, Robyn Murphy, Greg Kowalski, Clinton Bruce, Kirsten Howlett, Christopher Shaw

(2021), Vol. 534, pp. 533-539, Biochemical and Biophysical Research Communications, Amsterdam, The Netherlands, C1

journal article

Farmed mussels: A nutritive protein source, rich in Omega-3 fatty acids, with a low environmental footprint

E Yaghubi, S Carboni, R Snipe, C Shaw, J Fyfe, C Smith, G Kaur, S Tan, D Hamilton

(2021), Vol. 13, Nutrients, Switzerland, C1

journal article

Translating glucose tolerance data from mice to humans: Insights from stable isotope labelled glucose tolerance tests

C Bruce, S Hamley, T Ang, K Howlett, C Shaw, G Kowalski

(2021), Vol. 53, Molecular Metabolism, Germany, C1

journal article
2020

Impact of exercise training status on the fiber type-specific abundance of proteins regulating intramuscular lipid metabolism

C Shaw, C Swinton, M Morales-Scholz, N McRae, T Erftemeyer, A Aldous, R Murphy, K Howlett

(2020), Vol. 128, pp. 379-389, Journal of applied physiology, Rockville, Md., C1

journal article

Mapping the associations of the plasma lipidome with insulin resistance and response to an oral glucose tolerance test

H Beyene, S Hamley, C Giles, K Huynh, A Smith, M Cinel, N Mellet, M Morales-Scholz, D Kloosterman, K Howlett, G Kowalski, C Shaw, D Magliano, C Bruce, P Meikle

(2020), Vol. 105, pp. E1041-E1055, Journal of Clinical Endocrinology and Metabolism, United States, C1

journal article

High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men

L Parker, D Morrison, A Betik, K Roberts-Thomson, G Kaur, G Wadle, C Sha, M Kesk

(2020), Vol. 318, pp. E1014-E1021, American Journal of Physiology - Endocrinology and Metabolism, United States, C1

journal article

Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity

K De Jong, L Hall, M Renton, T Connor, S Martin, G Kowalski, C Shaw, C Bruce, K Howlett, S McGee

(2020), Vol. 42, Molecular Metabolism, Germany, C1

journal article
2019

Acute continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, attenuates postprandial suppression of circulating osteocalcin in young overweight and obese adults

L Parker, C Shaw, E Byrnes, N Stepto, I Levinger

(2019), Vol. 30, pp. 403-410, Osteoporosis international, Cham, Switzerland, C1

journal article

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

S Hamley, D Kloosterman, T Duthie, C Dalla Man, R Visentin, S Mason, T Ang, A Selathurai, G Kaur, M Morales-Scholz, K Howlett, G Kowalski, C Shaw, C Bruce

(2019), Vol. 62, pp. 2310-2324, Diabetologia, Berlin, Germany, C1

journal article
2018

Exercise-intensity dependent alterations in plasma redox status do not reflect skeletal muscle redox-sensitive protein signaling

L Parker, A Trewin, I Levinger, C Shaw, N Stepto

(2018), Vol. 21, pp. 416-421, Journal of science and medicine in sport, Amsterdam, The Netherlands, C1

journal article

In it together: a qualitative evaluation of participant experiences of a 10-week, group-based, workplace HIIT program for insufficiently active adults

Florence-Emilie Kinnafick, Cecilie Thøgersen-Ntoumani, Sam Shepherd, Oliver Wilson, Anton Wagenmakers, Christopher Shaw

(2018), Vol. 40, pp. 10-19, Journal of sport & exercise psychology, Champaign, Ill., C1

journal article

Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast-twitch hindlimb muscles

Alex Addinsall, Craig Wright, Chris Shaw, Natasha McRae, Leonard Forgan, Chia-Heng Weng, Xavier Conlan, Paul Francis, Zoe Smith, Sofianos Andrikopoulos, Nicole Stupka

(2018), Vol. 315, pp. R380-R396, American journal of physiology-regulatory, integrative and comparative physiology, Bethesda, Md., C1

journal article

Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work

A Trewin, L Parker, C Shaw, D Hiam, A Garnham, I Levinger, G McConell, N Stepto

(2018), Vol. 315, pp. R1003-R1016, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, United States, C1

journal article
2017

The effect of exercise-intensity on Skeletal muscle stress kinase and insulin protein signaling

L Parker, A Trewin, I Levinger, C Shaw, N Stepto

(2017), Vol. 12, PLoS ONE, United States, C1

journal article

Acute low-volume high-intensity interval exercise and continuous moderate-intensity exercise elicit a similar improvement in 24-h glycemic control in overweight and obese adults

L Parker, C Shaw, L Banting, I Levinger, K Hill, A McAinch, N Stepto

(2017), Vol. 7, Frontiers in Physiology, Switzerland, C1

journal article

Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling

K Sjøberg, C Frøsig, R Kjøbsted, L Sylow, M Kleinert, A Betik, C Shaw, B Kiens, J Wojtaszewski, S Rattigan, E Richter, G McConell

(2017), Vol. 66, pp. 1501-1510, Diabetes, United States, C1

journal article

Exercise and glycemic control: Focus on redox homeostasis and redox-sensitive protein signaling

L Parker, C Shaw, N Stepto, I Levinger

(2017), Vol. 8, Frontiers in Endocrinology, Switzerland, C1

journal article

Neutrophil and monocyte bactericidal responses to 10 weeks of low-volume high-intensity interval or moderate-intensity continuous training in sedentary adults

D Bartlett, S Shepherd, O Wilson, A Adlan, A Wagenmakers, C Shaw, J Lord

(2017), Vol. 2017, pp. 1-12, Oxidative medicine and cellular longevity, Cairo, Egypt, C1

journal article

Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men

A Trewin, I Levinger, L Parker, C Shaw, F Serpiello, M Anderson, G McConell, D Hare, N Stepto

(2017), Vol. 12, PLoS ONE, United States, C1

journal article

Lipid droplet remodelling and reduced muscle ceramides following sprint interval and moderate-intensity continuous exercise training in obese males

S Shepherd, M Cocks, P Meikle, N Mellett, A Ranasinghe, T Barker, A Wagenmakers, C Shaw

(2017), Vol. 41, pp. 1745-1754, International journal of obesity, London, Eng., C1

journal article
2016

Sprint interval and moderate-intensity continuous training have equal benefits on aerobic capacity, insulin sensitivity, muscle capillarisation and endothelial eNOS/NAD(P)Hoxidase protein ratio in obese men

M Cocks, C Shaw, S Shepherd, J Fisher, A Ranasinghe, T Barker, A Wagenmakers

(2016), Vol. 594, pp. 2307-2321, Journal of Physiology, England, C1

journal article

Intrinsic Motivation in Two Exercise Interventions: Associations With Fitness and Body Composition

C Thøgersen-Ntoumani, S Shepherd, N Ntoumanis, A Wagenmakers, C Shaw

(2016), Vol. 35, pp. 195-198, Health Psychology, United States, C1

journal article

Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria

J Strauss, C Shaw, H Bradley, O Wilson, T Dorval, J Pilling, A Wagenmakers

(2016), Vol. 4, Physiological reports, United States, C1

journal article

Acute high-intensity interval exercise-induced redox signaling is associated with enhanced insulin sensitivity in obese middle-aged men

L Parker, N Stepto, C Shaw, F Serpiello, M Anderson, D Hare, I Levinger

(2016), Vol. 7, Frontiers in Physiology, Switzerland, C1

journal article

Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic-hyperinsulinaemic clamp studies

S Cassar, M Misso, W Hopkins, C Shaw, H Teede, N Stepto

(2016), Vol. 31, pp. 2619-2631, Human reproduction, Oxford, Eng., C1

journal article
2015

What doesn't kill you makes you fitter: A systematic review of high-intensity interval exercise for patients with cardiovascular and metabolic diseases

I Levinger, C Shaw, N Stepto, S Cassar, A McAinch, C Cheetham, A Maiorana

(2015), Vol. 9, pp. 53-63, Clinical Medicine Insights: Cardiology, Auckland, New Zealand, C1

journal article

Low-volume high-intensity interval training in a gym setting improves cardio-metabolic and psychological health

S Shepherd, O Wilson, A Taylor, C Thøgersen-Ntoumani, A Adlan, A Wagenmakers, C Shaw

(2015), Vol. 10, pp. 1-17, PLoS ONE, San Francisco, Calif., C1-1

journal article

Visualization and quantitation of GLUT4 translocation in human skeletal muscle following glucose ingestion and exercise

H Bradley, C Shaw, C Bendtsen, P Worthington, O Wilson, J Strauss, G Wallis, A Turner, A Wagenmakers

(2015), Vol. 3, pp. 1-11, Physiological reports, Bethesda, M.D., C1

journal article
2014

Effect of resistance training on microvascular density and eNOS content in skeletal muscle of sedentary men

M Cocks, C Shaw, S Shepherd, J Fisher, A Ranasinghe, T Barker, K Tipton, A Wagenmakers

(2014), Vol. 21, pp. 738-746, Microcirculation, Chichester, Eng., C1-1

journal article

Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature

O Wilson, H Bradley, C Shaw, A Wagenmakers

(2014), Vol. 142, pp. 245-256, Histochemistry and cell biology, Heidelberg, Germany, C1-1

journal article

Resistance training increases skeletal muscle oxidative capacity and net intramuscular triglyceride breakdown in type I and II fibres of sedentary males

S Shepherd, M Cocks, K Tipton, O Witard, A Ranasinghe, T Barker, A Wagenmakers, C Shaw

(2014), Vol. 99, pp. 894-908, Experimental physiology, Chichester, Eng., C1-1

journal article

Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle: effects of endurance and sprint interval training

H Bradley, C Shaw, P Worthington, S Shepherd, M Cocks, A Wagenmakers

(2014), Vol. 2, pp. 1-16, Physiological reports, Malden, Mass., C1-1

journal article
2013

Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5

S Shepherd, M Cocks, K Tipton, A Ranasinghe, T Barker, J Burniston, A Wagenmakers, C Shaw

(2013), Vol. 591, pp. 657-675, Journal of physiology, London, Eng., C1-1

journal article

Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males

M Cocks, C Shaw, S Shepherd, J Fisher, A Ranasinghe, T Barker, K Tipton, A Wagenmakers

(2013), Vol. 591, pp. 641-656, Journal of physiology, London, Eng., C1-1

journal article
2012

Immunofluorescence microscopy to assess enzymes controlling nitric oxide availability and microvascular blood flow in muscle

M Cocks, S Shepherd, C Shaw, J Achten, M Costa, A Wagenmakers

(2012), Vol. 19, pp. 642-651, Microcirculation, Chichester, Eng., C1-1

journal article

Prolonged exercise training increases intramuscular lipid content and perilipin 2 expression in type I muscle fibers of patients with type 2 diabetes

C Shaw, S Shepherd, A Wagenmakers, D Hansen, P Dendale, L van Loon

(2012), Vol. 303, pp. E1158-E1165, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1-1

journal article

Lipid biomarkers of glioma cell growth arrest and cell death detected by 1H magic angle spinning MRS

L Mirbahai, M Wilson, C Shaw, C McConville, R Malcomson, R Kauppinen, A Peet

(2012), Vol. 25, pp. 1253-1262, NMR in biomedicine, Chichester, Eng., C1-1

journal article

Immunofluorescent visualisation of focal adhesion kinase in human skeletal muscle and its associated microvasculature

O Wilson, C Shaw, M Sherlock, P Stewart, A Wagenmakers

(2012), Vol. 138, pp. 617-626, Histochemistry and cell biology, Heidelberg, Germany, C1-1

journal article

Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise

S Shepherd, M Cocks, K Tipton, A Ranasinghe, T Barker, J Burniston, A Wagenmakers, C Shaw

(2012), Vol. 97, pp. 970-980, Experimental physiology, Chichester, Eng., C1-1

journal article
2011

Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals

C Shaw, N Cooper, O Shaw, P Salomao, A Wagenmakers

(2011), Vol. 111, pp. 2607-2613, European journal of applied physiology, Heidelberg, Germany, C1-1

journal article

1H magnetic resonance spectroscopy metabolites as biomarkers for cell cycle arrest and cell death in rat glioma cells

L Mirbahai, M Wilson, C Shaw, C McConville, R Malcomson, J Griffin, R Kauppinen, A Peet

(2011), Vol. 43, pp. 990-1001, International journal of biochemistry & cell biology, Amsterdam, The Netherlands, C1-1

journal article

Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion

L Breen, A Philp, C Shaw, A Jeukendrup, K Baar, K Tipton

(2011), Vol. 6, pp. 1-13, PLoS one, San Francisco, Calif., C1-1

journal article
2009

Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle

C Shaw, M Sherlock, P Stewart, A Wagenmakers

(2009), Vol. 131, pp. 575-581, Histochemistry and cell biology, Heidelberg, Germany, C1-1

journal article
2008

Network distribution of mitochondria and lipid droplets in human muscle fibres

C Shaw, D Jones, A Wagenmakers

(2008), Vol. 129, pp. 65-72, Histochemistry and cell biology, Berlin, Germany, C1-1

journal article
2007

Effect of acute exercise on glucose tolerance following post-exercise feeding

M Venables, C Shaw, A Jeukendrup, A Wagenmakers

(2007), Vol. 100, pp. 711-717, European journal of applied physiology, Berlin, Germany, C1-1

journal article
2005

Glucose polymer molecular weight does not affect exogenous carbohydrate oxidation

D Rowlands, G Wallis, C Shaw, R Jentjens, A Jeukendrup

(2005), Vol. 37, pp. 1510-1516, Medicine and science in sports and exercise, Philadelphia, Pa., C1-1

journal article

Oxidation of combined ingestion of glucose and sucrose during exercise

R Jentjens, C Shaw, T Birtles, R Waring, L Harding, A Jeukendrup

(2005), Vol. 54, pp. 610-618, Metabolism, Amsterdam, The Netherlands, C1-1

journal article

Oxidation of combined ingestion of maltodextrins and fructose during exercise

G Wallis, D Rowlands, C Shaw, R Jentjens, A Jeukendrup

(2005), Vol. 37, pp. 426-432, Medicine and science in sports and exercise, Philadelphia, Pa., C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Fasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance

A/Prof Chris Shaw, Prof Clinton Bruce, A/Prof Kirsten Howlett, Prof Sean Mcgee, Dr Greg Kowalski

Diabetes Australia Research Program Grant

  • 2021: $59,895

A novel ¿liquid biopsy¿ approach to study in vivo ¿-cell insulin synthesis in humans

Dr Greg Kowalski, Prof Clinton Bruce, A/Prof Chris Shaw

Diabetes Australia Research Program Grant

  • 2022: $69,340

Deciphering the mechanisms of prostprandial glucose disposal

A/Prof Chris Shaw, Prof Clinton Bruce, Dr Greg Kowalski, A/Prof Kirsten Howlett

Diabetes Australia Research Program Grant

  • 2022: $69,911

Industry and Other Funding

Palmitoylethanolamide (PEA) as an adjuvant to resistance training - can PEA enhance muscle growth, power and strength when combined with strength training?

Dr Lee Hamilton, Dr Jackson Fyfe, Dr Simon Feros, Dr Andrew Betik, A/Prof Chris Shaw, Dr Sze Yen Tan, A/Prof Luana Main

Gencor Pacific Limited

  • 2023: $80,000
  • 2022: $120,000
  • 2021: $54,464

Can dietary supplementation with Krill-Oil improve ME/CFS symptoms?

Dr Lee Hamilton, Prof Ken Walder, Dr Giselle Allsopp, A/Prof Chris Shaw, Dr Greg Kowalski, Prof Clinton Bruce, Dr Craig Wright, Dr Rhiannon Snipe

Equity Trustees - The Mason Foundation National Medical Program

  • 2024: $95,000
  • 2023: $90,000
  • 2022: $100,000

Supervisions

Principal Supervisor
2020

Maria Gabriela Morales Scholz

Thesis entitled: The impact of metabolic disease, feeding and exercise training on autophagy

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Associate Supervisor
2023

Mark Renton

Thesis entitled: The role of protein kinase D in obesity

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2022

Bianca Tepper

Thesis entitled: Extracellular Matrix Remodelling: Role in Insulin Resistance and Exercise Adaptations

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences