Staff profile - Paul Lewandowski
AsPr Paul Lewandowski
|Position:||Associate Professor |
|Faculty or Division:||Faculty of Health|
|Department:||School of Medicine|
|Campus:||Geelong Waurn Ponds Campus|
|Phone:||+61 3 522 71111 +61 3 522 71111|
|Fax:||+61 3 522 72945 +61 3 522 72945|
Dr Lewandowski serves as coordinator of anatomy in the Deakin Medical School, with overall responsibility for the teaching anatomy across the medical course. Dr Lewandowski also supervises honours and PhD students.
Awards and prizes
Dr Lewandowski was awarded the professional tile of Registered Nutritionist (RNutr) in 2010 and has received funding from both National Competitive Grant Schemes and Industry. He has also received a highly competitive Australian Nutrition Trust Fund travelling fellowship.
The over-arching goal of Dr Lewandowski’s research is to use diet and lifestyle to treat and prevent chronic disease. In attempting to achieve this goal he utilises a range of molecular biology techniques, biochemical tools, animal models and clinical samples to measure biomarkers of disease. Based on the understanding gained and mechanisms identified he then formulates dietary interventions to treat the condition. Dr Lewandowski currently heads a productive research team within the School of Medicine at Deakin University investigating three key research topics:
1. Oxidative stress. Increased levels of free radicals are known to be at the heart of a number of chronic diseases. Dr Lewandowski’s research group has investigated the mechanistic role oxidative stress plays in the development of fatty liver disease, metabolic syndrome, aging and muscle wasting. He has supervised an Alfred Deakin Postdoctoral Fellow, had 4 PhD students graduate and published 21 articles in this research area.
2. Metabolic syndrome. The increased prevalence of Metabolic Syndrome in the past 30 years and has become a major health concern in at risk populations, including migrants and people living in rural areas. Using biomarkers to diagnose and track the progress of diet and lifestyle interventions. His research group has had great success in treating metabolic syndrome in Pakistani migrants and farmers. This research theme currently employs 1 postdoctoral fellow, has had 3 PhD students graduate and published 23 articles.
3. Cancer cachexia. Unfortunately cachexia is a significant complication for a number of cancer patients, many of whom are terminally ill. Using a number of mouse models of cancer cachexia Dr Lewandowski’s research group has been investigating the underlying mechanisms that contribute to the development of the disease and have tested a number of new therapies that are now translating into the clinical setting. The mouse models are used in preclinical studies and complemented by a collaboration with the Barwon Health cachexia clinic. This ability to readily translate outcomes into the clinic has attracted considerable commercial funding. As a result of this commercial interest, investigations by his group into the treatment of cancer cachexia have seen this area grow rapidly over the past two years. Involving 2 postdoctoral fellows, had 1 PhD student graduate, published 4 articles and contributed to 2 patents in this research area.
Dr Lewandowski has a growing research program aimed at understanding how nutrition can be used to treat or prevent the development of age associated diseases including cancer cachexia, obesity and metabolic syndrome. Much of this work has involved combining cutting-edge molecular biology and laboratory techniques with dietary modification to treat disease, with a focus on at-risk rural and migrant populations.