Biography
Tania de Koning-Ward is a Professor in Molecular Microbiology and an NHMRC Senior Research Fellow within the School of Medicine and the Institute for Mental Health and Clinical Translation. She is currently the leader of the Infection, Immunity and Cancer Theme at IMPACT and she also heads a vibrant research team of postdocs, research assistants, PhD and Honours students in understanding the molecular basis of malaria.
Prof de Koning-Ward obtained her PhD from the University of Melbourne in 1996 and after two postdoctoral stints at Leiden University in The Netherlands, and at The Walter and Eliza Hall Institute in Melbourne as a Howard Florey Repatriation Fellow, she established her own research group within the School of Medicine in 2008 just as the School was opening its doors to its first intake of medical students.
Read more on Tania's profileCareer highlights
• NHMRC Howard Florey Centenary Fellowship (2000-2001)
• Deakin University Award for Research Excellence (2010)
• NHMRC Research Excellence Award (2010)
• NHMRC Career Development Fellowship (2011)
• Commonwealth Health Minister’s Prize for Excellence in Health and Medical Research (2011)
• Smart Geelong Network Biotechnology Award (2012)
• Smart Geelong Network Researcher of the Year Award (Highly Commended) (2012)
• Deakin University Health Faculty Award for Innovation in Teaching (2012)
• NHMRC Senior Research Fellowship (2018-2022)
Research interests
Malaria is one of the world’s most devastating human health problems, give rise to ~229 million cases each year, ~409,000 of which will be fatal. Unfortunately, there is no highly efficacious licenced malaria vaccine and resistance to currently available anti-malaria drugs is widespread. Thus, there is a desperate need to identify new intervention strategies to reduce the global malaria parasite burden.
Prof de Koning-Ward’s research program aims to investigate a molecular level, key parasite-host interactions that enable malaria parasites to thrive and survive in their host and cause disease. She utilises both human and rodent malaria transgenesis systems to genetically modify malaria genes to dissect gene function. The use of both transgenesis systems enables the characterisation of proteins in the clinically relevant human malaria parasite, which is predominantly cultured in blood cells in vitro, and the dissection of the functional significance and contribution of these proteins to pathogenesis and immunity using an in vivo model of malaria infection. By understanding the key mechanisms by which parasites are able to survive within their host and cause disease, her research aims to discover new drug targets that can be used to prevent the large morbidity and mortality associated with malaria infections.
We are now recruiting Honours and PhD Students to work on the following project areas. Please email expressions of interest to Prof de Koning-Ward.
Teaching interests
Professor de Koning-Ward joined the School of Medicine at Deakin University when it was opening its doors to its first intake of medical students. For several years she coordinated the Infection, Defence and Repair Unit for 1st year medical students. She developed the School of Medicine’s Honours Course and more recently the Masters of Philosophy Program for which she is currently the Course Director.
Knowledge areas
Infectious diseases, microbiology, parasitology, immunology, molecular biology, cellular biology, biochemistry, functional genomics, genetic engineering, pathogenesis, virulence, animal models of disease, host-pathogen interaction
Projects
Malaria is one of the world’s most devastating human health problems, give rise to ~229 million cases each year, ~409,000 of which will be fatal. Unfortunately, there is no highly efficacious licenced malaria vaccine and resistance to currently available anti-malaria drugs is widespread. Thus, there is a desperate need to identify new intervention strategies to reduce the global malaria parasite burden.
Prof de Koning-Ward’s research program aims to investigate a molecular level, key parasite-host interactions that enable malaria parasites to thrive and survive in their host and cause disease. She utilises both human and rodent malaria transgenesis systems to genetically modify malaria genes to dissect gene function. The use of both transgenesis systems enables the characterisation of proteins in the clinically relevant human malaria parasite, which is predominantly cultured in blood cells in vitro, and the dissection of the functional significance and contribution of these proteins to pathogenesis and immunity using an in vivo model of malaria infection. By understanding the key mechanisms by which parasites are able to survive within their host and cause disease, her research aims to discover new drug targets that can be used to prevent the large morbidity and mortality associated with malaria infections.
We are now recruiting Honours and PhD Students to work on the following project areas. Please email expressions of interest to Prof de Koning-Ward.
• Understanding how malaria parasites remodel the host cells in which they reside
• Dissecting how malaria parasites obtain nutrients essential to their survival
• Dissecting host proteins that contribute to malaria pathogenesis
• Characterising the role of malaria aminopeptidases in hemoglobin digestion
• Dissecting how malaria parasites traffic diverse proteins to distinct cellular locations
• Screening for drugs that target malaria parasites and delineating their mode of action
Publications
Dissecting EXP2 sequence requirements for protein export in malaria parasites
E Pitman, N Counihan, J Modak, M Chowdury, P Gilson, C Webb, T de Koning-Ward
(2024), Vol. 13, pp. 1-15, Frontiers in Cellular and Infection Microbiology, Lausanne, Switzerland, C1
Altered gastrointestinal tract structure and microbiome following cerebral malaria infection
S Knowler, A Shindler, J Wood, A Lakkavaram, C Thomas, T de Koning-Ward, E Hill-Yardin, T Carvalho, A Franks
(2023), Vol. 122, pp. 789-799, Parasitology Research, Germany, C1
M Dans, H Piirainen, W Nguyen, S Khurana, S Mehra, Z Razook, N Geoghegan, A Dawson, S Das, M Schneider, T Jonsdottir, M Gabriela, M Gancheva, C Tonkin, V Mollard, C Goodman, G McFadden, D Wilson, K Rogers, A Barry, B Crabb, T de Koning-Ward, B Sleebs, I Kursula, P Gilson
(2023), Vol. 21, pp. 1-34, PLoS Biology, San Francisco, Calif., C1
Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis
Saeed Maymand, Asha Lakkavaram, Wasan Naser, Parisa Rasighaemi, Daniel Dlugolenski, Clifford Liongue, John Stambas, Tania de Koning-Ward, Alister Ward
(2023), Vol. 13, pp. 1-11, Biomolecules, Basel, Switzerland, C1
Suffian Azizan, Shamista Selvarajah, Jingyi Tang, Myriam Jeninga, Danae Schulz, Kapil Pareek, Tamara Herr, Karen Day, Tania De Koning-Ward, Michaela Petter, Michael Duffy
(2023), pp. 1-21, mBio, Washington, D.C., C1
M Gabriela, C Barnes, D Leong, B Sleebs, M Schneider, D Littler, B Crabb, T de Koning-Ward, P Gilson
(2023), pp. 1-16, Traffic, London, Eng., C1
A Lakkavaram, S Maymand, W Naser, A Ward, T de Koning-Ward
(2023), Vol. 14, pp. 1-12, Frontiers in Microbiology, Lausanne, Switzerland, C1
Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis
Samuel Wassmer, Tania de Koning-Ward, Georges Grau, Saparna Pai
(2023), pp. 1-17, Trends in Parasitology, Amsterdam, The Netherlands, C1
Methods Used to Investigate the Plasmodium falciparum Digestive Vacuole
R Edgar, N Counihan, S McGowan, T de Koning-Ward
(2022), Vol. 11, pp. 1-12, Frontiers in Cellular and Infection Microbiology, Lausanne, Switzerland, C1
M Gabriela, K Matthews, C Boshoven, B Kouskousis, T Jonsdottir, H Bullen, J Modak, D Steer, B Sleebs, B Crabb, T de Koning-Ward, P Gilson
(2022), Vol. 18, pp. 1-32, PLoS Pathogens, San Francisco, Calif., C1
H Bullen, P Sanders, M Dans, T Jonsdottir, D Riglar, O Looker, C Palmer, B Kouskousis, S Charnaud, T Triglia, M Gabriela, M Parkyn Schneider, J Chan, T de Koning-Ward, J Baum, J Kazura, J Beeson, A Cowman, P Gilson, B Crabb
(2022), Vol. 117, pp. 1245-1262, Molecular Microbiology, England, C1
Post-translational lipid modifications in Plasmodium parasites
N Counihan, H Chernih, T de Koning-Ward
(2022), Vol. 69, pp. 1-9, Current Opinion in Microbiology, Amsterdam, The Netherlands, C1
R Edgar, G Siddiqui, K Hjerrild, T Malcolm, N Vinh, C Webb, C Holmes, C Macraild, H Chernih, W Suen, N Counihan, D Creek, P Scammells, S McGowan, T de Koning-Ward
(2022), Vol. 11, eLife, England, C1
W Nguyen, M Dans, A Ngo, M Gancheva, O Romeo, S Duffy, T de Koning-Ward, K Lowes, H Sabroux, V Avery, D Wilson, P Gilson, B Sleebs
(2021), Vol. 214, European Journal of Medicinal Chemistry, France, C1
T Jonsdottir, N Counihan, J Modak, B Kouskousis, P Sanders, M Gabriela, H Bullen, B Crabb, T de Koning-Ward, P Gilson
(2021), Vol. 23, Cellular Microbiology, England, C1
How Malaria Parasites Acquire Nutrients From Their Host
N Counihan, J Modak, T de Koning-Ward
(2021), Vol. 9, Frontiers in Cell and Developmental Biology, Switzerland, C1
J Qin, M Lovelace, A Mitchell, T de Koning-Ward, G Grau, S Pai
(2021), Vol. 10, Clinical and Translational Immunology, Australia, C1
Defining the Essential Exportome of the Malaria Parasite
T Jonsdottir, M Gabriela, B Crabb, T F. de Koning-Ward, P Gilson
(2021), Vol. 37, pp. 664-675, Trends in Parasitology, England, C1
C Schnider, H Yang, L Starrs, A Ehmann, F Rahimi, E Di Pierro, G Graziadei, K Matthews, T De Koning-Ward, D Bauer, S Foote, G Burgio, B McMorran
(2020), Vol. 10, Frontiers in Cellular and Infection Microbiology, Switzerland, C1
M Dans, G Weiss, D Wilson, B Sleebs, B Crabb, T de Koning-Ward, P Gilson
(2020), Vol. 50, pp. 235-252, International Journal for Parasitology, Amsterdam, The Netherlands, C1
A Lakkavaram, R Lundie, H Do, A Ward, T de Koning-Ward
(2020), Vol. 11, Frontiers in Microbiology, Switzerland, C1
A Valencia-Hernandez, W Ng, N Ghazanfari, S Ghilas, M de Menezes, L Holz, C Huang, K English, M Naung, P Tan, K Tullett, T Steiner, M Enders, L Beattie, Y Chua, C Jones, A Cozijnsen, V Mollard, Y Cai, D Bowen, A Purcell, N La Gruta, J Villadangos, T de Koning-Ward, A Barry, W Barchet, I Cockburn, G McFadden, S Gras, M Lahoud, P Bertolino, R Schittenhelm, I Caminschi, W Heath, D Fernandez-Ruiz
(2020), Vol. 27, pp. 950-962.e7, Cell Host and Microbe, United States, C1
Plasmodium translocon component EXP2 facilitates hepatocyte invasion
J Mello-Vieira, F Enguita, T de Koning-Ward, V Zuzarte-Luís, M Mota
(2020), Vol. 11, Nature Communications, England, C1
Illuminating how malaria parasites export proteins into host erythrocytes
K Matthews, E Pitman, T de Koning-Ward
(2019), Vol. 21, Cellular Microbiology, India, C1
Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
Amy Burns, Madeline Dans, Juan Balbin, Tania De Koning-Ward, Paul Gilson, James Beeson, Michelle Boyle, Danny Wilson
(2019), Vol. 43, pp. 223-238, FEMS microbiology reviews, Oxford, Eng., C1
K Matthews, M Kalanon, T de Koning-Ward
(2019), Vol. 10, mBio, United States, C1
P Gilson, R Kumarasingha, J Thompson, X Zhang, J Penington, R Kalhor, H Bullen, A Lehane, M Dans, T de Koning-Ward, J Holien, T Soares da Costa, M Hulett, M Buskes, B Crabb, K Kirk, A Papenfuss, A Cowman, B Abbott
(2019), Vol. 9, Scientific Reports, England, C1
S Ghosh, S Chisholm, M Dans, A Lakkavaram, K Kennedy, S Ralph, N Counihan, T De Koning-Ward
(2018), Vol. 13, PLoS ONE, United States, C1
S Hallée, N Counihan, K Matthews, T de Koning-Ward, D Richard
(2018), Vol. 20, Cellular Microbiology, India, C1
The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface
Scott Chisholm, Ming Kalanon, Thomas Nebl, Paul Sanders, Kathryn Matthews, Benjamin Dickerman, Paul Gilson, Tania de Koning-Ward
(2018), Vol. 285, pp. 2037-2055, FEBS journal, Chichester, Eng., C1
Host cell remodelling in malaria parasites: a new pool of potential drug targets
P Gilson, S Chisholm, B Crabb, T de Koning-Ward
(2017), Vol. 47, pp. 119-127, International Journal for Parasitology, Lorne, AUSTRALIA, C1
S Ghosh, K Kennedy, P Sanders, K Matthews, S Ralph, N Counihan, T de Koning-Ward
(2017), Vol. 19, Cellular Microbiology, India, C1
N Counihan, S Chisholm, H Bullen, A Srivastava, P Sanders, T Jonsdottir, G Weiss, S Ghosh, B Crabb, D Creek, P Gilson, T De Koning-Ward
(2017), Vol. 6, eLife, England, C1
S Batinovic, E McHugh, S Chisholm, K Matthews, B Liu, L Dumont, S Charnaud, M Schneider, P Gilson, T De Koning-Ward, M Dixon, L Tilley
(2017), Vol. 8, Nature Communications, England, C1
D Fernandez-Ruiz, L Lau, N Ghazanfari, C Jones, W Ng, G Davey, D Berthold, L Holz, Y Kato, M Enders, G Bayarsaikhan, S Hendriks, L Lansink, J Engel, M Soon, K James, A Cozijnsen, V Mollard, A Uboldi, C Tonkin, T de Koning-Ward, P Gilson, T Kaisho, A Haque, B Crabb, F Carbone, G McFadden, W Heath
(2017), Vol. 199, pp. 4165-4179, Journal of immunology, Bethesda, Md., C1
M Kalanon, D Bargieri, A Sturm, K Matthews, S Ghosh, C Goodman, S Thiberge, V Mollard, G Mcfadden, R Ménard, T de Koning-Ward
(2016), Vol. 18, pp. 399-412, Cellular Microbiology, India, C1
S Chisholm, E McHugh, R Lundie, M Dixon, S Ghosh, M O'Keefe, L Tilley, M Kalanon, T De Koning-Ward
(2016), Vol. 11, PLoS ONE, United States, C1-1
B Elsworth, P Sanders, T Nebl, S Batinovic, M Kalanon, C Nie, S Charnaud, H Bullen, T de Koning Ward, L Tilley, B Crabb, P Gilson
(2016), Vol. 18, pp. 1551-1569, Cellular Microbiology, India, C1
Plasmodium species: Master renovators of their host cells
T De Koning-Ward, M Dixon, L Tilley, P Gilson
(2016), Vol. 14, pp. 494-507, Nature Reviews Microbiology, England, C1
E Silberhorn, U Schwartz, P Löffler, S Schmitz, A Symelka, T de Koning-Ward, R Merkl, G Längst
(2016), Vol. 12, PLoS Pathogens, United States, C1
Advances in molecular genetic systems in malaria
T de Koning-Ward, P Gilson, B Crabb
(2015), Vol. 13, pp. 373-387, Nature reviews microbiology, London, Eng., C1
PTEX is an essential nexus for protein export in malaria parasites
B Elsworth, K Matthews, C Nie, M Kalanon, S Charnaud, P Sanders, S Chisholm, N Counihan, P Shaw, P Pino, J Chan, M Azevedo, S Rogerson, J Beeson, B Crabb, P Gilson, T de Koning-Ward
(2014), Vol. 511, pp. 587-591, Nature, London, United Kingdom, C1
L Lau, D Fernandez-Ruiz, V Mollard, A Sturm, M Neller, A Cozijnsen, J Gregory, G Davey, C Jones, Y Lin, A Haque, C Engwerda, C Nie, D Hansen, K Murphy, A Papenfuss, J Miles, S Burrows, T de Koning-Ward, G McFadden, F Carbone, B Crabb, W Heath
(2014), Vol. 10, pp. 1-16, PLoS pathogens, San Francisco, CA, C1
Host cell remodelling and protein trafficking
S Haase, H Bullen, S Charnaud, B Crabb, P Gilson, T de Koning Ward
(2013), pp. 199-219, Malaria parasites : comparative genomics, evolution and molecular biology, [Wymondham, England], B1
S Haase, E Hanssen, K Matthews, M Kalanon, T de Koning-Ward
(2013), Vol. 8, pp. 1-11, PLoS one, San Francisco, Calif., C1
Plasmodium rhoptry proteins: why order is important
N Counihan, M Kalanon, R Coppel, T de Koning-Ward
(2013), Vol. 29, pp. 228-236, Trends in parasitology, Oxford, England, C1
K Matthews, M Kalanon, S Chisholm, A Sturm, C Goodman, M Dixon, P Sanders, T Nebl, F Fraser, S Haase, G McFadden, P Gilson, B Crabb, T de Koning-Ward
(2013), pp. 1-20, Molecular microbiology, Chichester, England, C1
H Bullen, S Charnaud, M Kalanon, D Riglar, C Dekiwadia, N Kangwanrangsan, M Torii, T Tsuboi, J Baum, S Ralph, A Cowman, T de Koning-Ward, B Crabb, P Gilson
(2012), Vol. 287, pp. 7871-7884, Journal of biological chemistry, Bethesda, Md., C1
F Ehlgen, J Pham, T de Koning-Ward, A Cowman, S Ralph
(2012), Vol. 7, PLoS One, San Francisco, Calif., C1
L Lau, D Ruiz, G Davey, T de Koning-Ward, A Papenfuss, F Carbone, A Brooks, B Crabb, W Heath
(2011), Vol. 204, pp. 1989-1996, Journal of infectious diseases, Cary, N.C., C1
Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
B Crabb, T de Koning-Ward, P Gilson
(2011), Vol. 9, pp. 1-4, BMC biology, London, U. K., C1
A research agenda for malaria eradication: basic science and enabling technologies
R Dinglasan, M Mota, J Baum, O Billker, T Bousema, V McGovern, I Mueller, R Amino, Q Bassat, M Bogyo, G Christophides, K Deitsch, A Djimde, M Duraisingh, F Dzinjalamala, C Happi, V Heussler, J Kramarik, T de Koning-Ward, M Lacerda, M Laufer, P Lim, M Llinas, J Martinez-Barnetche, F Okumu, J Rasgon, A Serazin, P Sharma, R Sinden, D Wirth
(2011), Vol. 8, pp. 1-6, PLoS Medicine, San Francisco, Calif., C1-1
New insights into protein export in malaria parasites
S Haase, T de Koning-Ward
(2010), Vol. 12, pp. 580-587, Cellular microbiology, London, England, C1
B Crabb, T de Koning-Ward, P Gilson
(2010), Vol. 40, pp. 509-513, International Journal for parasitology, Amsterdam, The Netherlands, C1
Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria
F Amante, A Haque, A Stanley, F de Labastida Rivera, L Randall, Y Wilson, G Yeo, C Pieper, B Crabb, T de Koning-Ward, R Lundie, M Good, A Pinzon-Charry, M Pearson, M Duke, D McManus, A Loukas, G Hill, C Engwerda
(2010), Vol. 185, pp. 3632-3642, Journal of immunology, Bethesda, Md., C1
The clp chaperones and proteases of the human malaria parasite Plasmodium falciparum
M El Bakkouri, A Pow, A Mulichak, K Cheung, J Artz, M Amani, S Fell, T de Koning-Ward, C Goodman, G McFadden, J Ortega, R Hui, W Houry
(2010), Vol. 404, pp. 456-477, Journal of molecular biology, Amsterdam, The Netherlands, C1
An aspartyl protease directs malaria effector proteins to the host cell
J Boddey, A Hodder, S Gunther, P Gilson, H Patsiouras, E Kapp, A Pearce, T de Koning-Ward, R Simpson, B Crabb, A Cowman
(2010), Vol. 463, pp. 627-631, Nature, London, England, C1
Keeping it simple: an easy method for manipulating the expression levels of malaria proteins
T de Koning-Ward, P Gilson
(2009), Vol. 25, pp. 4-7, Trends in parasitology, London, England, C1-1
Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites
J Baum, A Papenfuss, G Mair, C Janse, D Vlachou, A Waters, A Cowman, B Crabb, T de Koning-Ward
(2009), Vol. 37, pp. 3788-3798, Nucleic acids research, Oxford, England, C1-1
A newly discovered protein export machine in malaria parasites
T de Koning-Ward, P Gilson, J Boddey, M Rug, B Smith, A Papenfuss, P Sanders, R Lundie, A Maier, A Cowman, B Crabb
(2009), Vol. 459, pp. 945-950, Nature, London, England, C1-1
R Lundie, T de Koning-Ward, G Davey, C Nie, D Hansen, L Lau, J Mintern, G Belz, L Schofield, F Carbone, J Villadangos, B Crabb, W Heath
(2008), Vol. 105, pp. 14509-14514, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1
T de Koning-Ward, D Drew, J Chesson, J Beeson, B Crabb
(2008), Vol. 159, pp. 69-72, Molecular and biochemical parasitology, Amsterdam, Netherlands, C1
E Murhandarwati, C Black, L Wang, S Weisman, T de Koning-Ward, J Baird, E Tjitra, T Richie, B Crabb, R Coppel
(2008), Vol. 198, pp. 1212-1218, The journal of infectious diseases, Chicago, Ill., C1-1
T de Koning-Ward, A Olivieri, L Bertuccini, A Hood, F Silvestrini, K Charvalias, P Diaz, G Camarda, T McElwain, T Papenfuss, J Healer, L Baldassarri, B Crabb, P Alano, L Ranford-Cartwright
(2008), Vol. 67, pp. 278-290, Molecular microbiology, Oxford, England, C1-1
P Gilson, R O'Donnell, T Nebl, P Sanders, M Wickham, T McElwain, T de Koning-Ward, B Crabb
(2008), Vol. 68, pp. 124-138, Molecular microbiology, Oxford, England, C1-1
The importance of human FcyRI in mediating protection to malaria
R McIntosh, J Shi, R Jennings, J Chappel, T de Koning-Ward, T Smith, J Green, M van Egmond, J Leusen, M Lazarou, J van de Winkel, T Jones, B Crabb, A Holder, R Pleass
(2007), Vol. 3, pp. 647-658, PLoS pathogens, San Francisco, CA, C1-1
J McCoubrie, S Miller, T Sargeant, R Good, A Hodder, T Speed, T de Koning-Ward, B Crabb
(2007), Vol. 75, pp. 5565-5574, Infection and immunity, Washington, D.C., C1-1
N Wilson, G Behrens, R Lundie, C Smith, J Waithman, L Young, S Forehan, A Mount, R Steptoe, K Shortman, T de Koning-Ward, G Belz, F Carbone, B Crabb, W Heath, J Villadangos
(2006), Vol. 7, pp. 165-172, Nature immunology, New York, N. Y., C1-1
M Meissner, E Krejany, P Gilson, T de Koning-Ward, D Soldati, B Crabb
(2005), Vol. 102, pp. 2980-2985, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1-1
C John, R O'Donnell, P Sumba, A Moormann, T de Koning-Ward, C King, J Kazura, B Crabb
(2004), Vol. 173, pp. 666-672, Journal of immunology, Bethesda, Md., C1-1
T de Koning-Ward, R O'Donnell, D Drew, R Thomson, T Speed, B Crabb
(2003), Vol. 198, pp. 869-875, The journal of experimental medicine, New York, N. Y., C1-1
D Hansen, M Siomos, T de Koning-Ward, L Buckingham, B Crabb, L Schofield
(2003), Vol. 33, pp. 2588-2598, European journal of immunology, Weinheim, Germany, C1-1
S Miller, R Good, D Drew, M Delorenzi, P Sanders, A Hodder, T Speed, A Cowman, T de Koning-Ward, B Crabb
(2002), Vol. 277, pp. 47524-47532, Journal of biological chemistry, Rockville, Md., C1-1
R O'Donnell, T de Koning-Ward, R Burt, M Bockarie, J Reeder, A Cowman, B Crabb
(2001), Vol. 193, pp. 1403-1412, Journal of experimental medicine, New York, N.Y., C1-1
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions
A Tomas, G Margos, G Dimopoulos, L van Lin, T de Koning-Ward, R Sinha, P Lupetti, A Beetsma, M Rodriguez, M Karras, A Hager, J Mendoza, G Butcher, F Kafatos, C Janse, A Waters, R Sinden
(2001), Vol. 20, pp. 3975-3983, EMBO journal, Chichester, Eng., C1-1
Puromycin-N-acetyltransferase as a selectable marker for use in plasmodium falciparum
T de Koning-Ward, A Waters, B Crabb
(2001), Vol. 117, pp. 155-160, Molecular & biochemical parasitology, Amsterdam, The Netherlands, C1-1
A Sultan, V Thathy, T de Koning-Ward, V Nussenzweig
(2001), Vol. 113, pp. 151-156, Molecular & biochemical parasitology, Amsterdam, The Netherlands, C1-1
T de Koning-Ward, D Fidock, V Thathy, R Menard, R van Spaendonk, A Waters, C Janse
(2000), Vol. 106, pp. 199-212, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1
The development of genetic tools for dissecting the biology of malaria parasites
T de Koning-Ward, C Janse, A Waters
(2000), Vol. 54, pp. 157-185, Annual review of microbiology, Palo Alto, Calif., C1-1
Analysis of stage specificity of promoters in Plasmodium berghei using luciferase as a reporter
T de Koning-Ward, M Sperança, A Waters, C Janse
(1999), Vol. 100, pp. 141-146, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1
T de Koning-Ward, T Grant, F Oppedisano, R Robins-Browne
(1998), Vol. 215, pp. 39-44, Journal of immunological methods, Amsterdam, The Netherlands, C1-1
M Starr, V Bennett-Wood, A Bigham, T de Koning-Ward, A Bordun, D Lightfoot, K Bettelheim, C Jones, R Robins-Browne
(1998), Vol. 27, pp. 310-315, Clinical infectious diseases, Oxford, Eng., C1-1
Stable expression of green fluorescent protein in blood and mosquito stages of Plasmodium berghei
T de Koning-Ward, A Thomas, A Waters, C Janse
(1998), Vol. 97, pp. 247-252, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1
Analysis of the urease gene complex of members of the genus Yersinia
T de Koning-Ward, R Robins-Browne
(1996), Vol. 182, pp. 225-228, Gene, Amsterdam, The Netherlands, C1-1
Contribution of urease to acid tolerance in Yersinia enterocolitica
T De Koning-Ward, R Robins-Browne
(1995), Vol. 63, pp. 3790-3795, Infection and immunity, Washington, D.C., C1-1
Characterisation of the urease-encoding gene complex of Yersinia enterocolitica
T de Koning-Ward, A Ward, R Robins-Browne
(1994), Vol. 145, pp. 25-32, Gene, Amsterdam, The Netherlands, C1-1
Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems
T ROBBINS
(1987), Vol. 26, pp. 893-901, Neuropharmacology, England, C1-1
Funded Projects at Deakin
Australian Competitive Grants
Dissecting the contribution of malaria translocon components to pathogenesis
Prof Tania De Koning-Ward
NHMRC Project Grant
- 2011: $100,444
- 2010: $98,689
- 2009: $127,450
Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts
Dr Paul Gilson, Prof Tania De Koning-Ward, Dr Justin Boddey
NHMRC Project Grant
- 2010: $45,000
Dissection of protein export in Plasmodium
Prof Tania De Koning-Ward
NHMRC CDF - Career Development Fellowship
- 2014: $113,863
- 2013: $111,960
- 2012: $109,980
- 2011: $158,142
Functional dissection of the malaria protein export machinery
Prof Tania De Koning-Ward, Dr Paul Gilson
NHMRC Project Grant
- 2015: $1,624
- 2014: $142,475
- 2013: $99,365
- 2012: $25,601
Functional dissection of the malaria RhopH complex and its contribution to new permeation pathways
Prof Tania De Koning-Ward, Dr Paul Gilson
NHMRC Project Grant
- 2018: $35,534
- 2017: $135,283
- 2016: $92,219
- 2015: $98,341
The structural resolution of PTEX, the translocon of virulence proteins and malaria parasites
Prof Brendan Crabb, A/Prof Travis Beddoe, Prof Tania De Koning-Ward, Dr Paul Gilson
NHMRC Project Grant
- 2016: $54,346
- 2015: $43,477
- 2014: $32,608
Investigating why malaria parasites have a unique translocon
Prof Tania De Koning-Ward, Dr Paul Gilson
ARC - Discovery Projects
- 2018: $127,980
- 2017: $121,255
- 2016: $90,241
Breaking malaria's lethal grip: Targeting the assembly of an adhesive complex on infected red blood cells
Prof Leann Tilley, Dr Paul Gilson, Prof Tania De Koning-Ward, Dr Matthew Dixon
NHMRC Project Grant
- 2017: $43,276
- 2016: $43,276
- 2015: $47,507
Interaction of malaria parasites with their host
Prof Tania De Koning-Ward
NHMRC - Research Fellowship
- 2022: $136,988
- 2021: $135,497
- 2020: $133,627
- 2019: $131,782
- 2018: $129,834
The role of novel and essential bromodomain proteins in coordinating malaria parasite gene regulation and their potential as anti-malarial targets
Dr Michael Duffy, Prof Tania De Koning-Ward, Prof Stefan Knapp
NHMRC Project Grant
- 2019: $48,000
- 2018: $50,000
- 2017: $50,000
Functional resolution of PTEX, the exporter of virulence factors in malaria parasites.
Prof Brendan Crabb, A/Prof Travis Beddoe, Prof Tania De Koning-Ward, Dr Paul Gilson
NHMRC Project Grant
- 2020: $39,700
- 2019: $39,700
- 2018: $39,700
- 2017: $39,700
Role of plasmepsin V and PTEX complex in Plasmodium liver infection
Dr Justin Boddey, Prof Tania De Koning-Ward, Dr Kelly Rogers, Prof Norman Kneteman
NHMRC Project Grant
- 2020: $59,836
- 2019: $47,869
- 2018: $35,901
Deciphering the molecular constituents, assembly and structure of the Plasmodium new permeability pathways
Prof Tania De Koning-Ward, Dr Natalie Counihan, Dr Joyanta Modak, Dr Rowena Martin
NHMRC - Ideas Grant
- 2023: $126,871
- 2022: $249,502
- 2021: $241,646
- 2020: $133,452
Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Prof Susan Charman, Prof Tania De Koning-Ward, Dr Paul Gilson
NHMRC Synergy Grants
- 2024: $41,666
- 2023: $166,666
- 2022: $166,666
- 2021: $166,666
- 2020: $166,666
Other Public Sector Funding
The role of host factors in viral pathogenesis
Prof Tania De Koning-Ward, Ms Katherine Birrer
CSIRO Livestock Industries - Commonwealth Scientific and Industrial Research Organisation
- 2012: $4,257
- 2011: $3,092
Identification of novel protective malaria vaccine antigen candidate
Prof Tania De Koning-Ward, Ms Sreejoyee Ghosh
Victoria India Doctoral Scholarships
- 2012: $90,000
Targeting site specific improvements of clinical trial operational processes - Ethan Pitman internship
Prof Tania De Koning-Ward, Mr Ethan Pitman
Ballarat Health Services
- 2022: $30,000
Industry and Other Funding
VCCC SKILLED Internship Program
Prof Tania De Koning-Ward, Miss Christina Dizdarevic, Ms Krystle Wilson
VCCC Alliance Ltd
- 2024: $14,300
Other Funding Sources
Collaborative High Bio-Containment immunological Research Facility
Prof Alister Ward, Dr Linfa Wang, Prof John Stambas, Dr John Lowenthal, Prof Ralph Tripp, Prof Bill Buttemer, Prof Johnson Mak, Prof Tania De Koning-Ward
ARC LIEF - Linkage Infrastructure Equipment & Facilities Program, CSIRO Commonwealth Scientific and Industrial Research Organisation
- 2012: $105,000
- 2011: $100,000
The role of host factors in viral pathogenesis
Prof Tania De Koning-Ward, Ms Katherine Birrer
Poultry CRC
- 2011: $7,000
Supervisions
Rebecca Edgar
Thesis entitled: Characterising the aminopeptidases of Plasmodium falciparum as potential drug targets
Doctor of Philosophy (Medicine), School of Medicine
Ethan Pitman
Thesis entitled: Dissection of the assembly and operation of the Plasmodium export machinery
Doctor of Philosophy (Medicine), School of Medicine
Madeline Grace Dans
Thesis entitled: Identifying Inhibitors that Target Egress and Invasion of Plasmodium falciparum
Doctor of Philosophy (Medicine), School of Medicine
Mikha Gabriela
Thesis entitled: Molecular mechanism of cargo recognition by the Plasmodium translocon of exported proteins
Doctor of Philosophy (Medicine), School of Medicine
Rebecca Edgar
Thesis entitled: Starving the Malaria Parasite
Master of Philosophy (Medicine), School of Medicine
Asha Latha Lakkavaram
Thesis entitled: Dissecting the mechanism of severe malaria
Doctor of Philosophy (Medicine), School of Medicine
Sreejoyee Ghosh
Thesis entitled: Dissecting the function of essential rhoptry genes of the malaria parasite
Doctor of Philosophy (Medicine), School of Medicine
Scott Chisholm
Thesis entitled: Characterisation of PTEX88, a component of the Plasmodium translocon
Doctor of Philosophy (Medicine), School of Medicine
Kathryn Mifsud
Thesis entitled: PTEX characterisation and its role in Plasmodium virulence and survival
Doctor of Philosophy (Medicine), School of Medicine
Ming Tsung Lee
Thesis entitled: Cost and Utilisation of Physical Therapies in Taiwan
Doctor of Philosophy (Medicine), School of Medicine
Katherine Birrer
Thesis entitled: Silencing Host Genes Using RNAi to Impact Virus Growth in vitro Methods for reducing cotton wax.
MAppSc (Medicine) (High cost), School of Medicine
Raj Sanjiv Khatri
Thesis entitled: Role of mucin 1 in Malaria-Associated Acute Respiratory Distress Syndrome
Master of Philosophy (Medicine), School of Medicine
Shasha Zhao
Thesis entitled: The Role of miRNAs in Influenza Virus Pathogenesis and Immunity
Doctor of Philosophy (Medicine), School of Medicine
Saeed Mahmoudimeimand
Thesis entitled: Control of cytokine receptor signalling by CISH
Doctor of Philosophy (Medicine), School of Medicine
Hanumantsingh Tanwar
Thesis entitled: Regulation of HIV Gag conformation and complex formation
Doctor of Philosophy (Medicine), School of Medicine
Kate Goossens
Thesis entitled: Comparative analysis of type III interferon receptor and interferon-stimulated genes
Doctor of Philosophy (Medicine), School of Medicine