- Study at Deakin
- Campus life
- Industry and community
- About Deakin
Biodegradable polymers are widely used in biomedical applications, particularly in tissue engineering and controlled drug delivery. We investigate the synthesis, processing and application of biodegradable polymers.
Synthesis of PPG-PEI crosslinked copolymers. Novel biodegradable PPG-PEI crosslinked copolymers were prepared from poly(propylene glycol) (PPG)-type epoxy resin and poly(ethylene imine) (PEI). Chinese hamster ovary cells were cultured on the PPG-PEI copolymers. The cell viability rate, relative to tissue-culture polystyrene, increased from 49% to 125% with increasing PEI content from 18.5 wt% to 40 wt%. Although epoxy monomers usually exhibit cytotoxicity, the epoxy groups were exhausted via curing reaction in the fully crosslinked copolymers. The PEI-cured PPG epoxy resin, i.e. PPG-PEI crosslinked copolymers obtained in this study, showed excellent biocompatibility (Ding, Y., Wang, J., Wong, C. S., Halley, P. J. and Guo, Q., J. Biomater. Sci., Polym. Ed. 2011, 22, 457-473).
Chinese hamster ovary cells seeded on PPG-PEI crosslinked copolymer with 30 wt% PEI in (a) 4 hrs, (b) 1 day and (c) 3 days.
Synthesis of poly(Nα-Boc-L-tryptophan) based amphiphilic block copolymers. Poly(ethylene glycol)-block-poly(Nα-Boc-L-tryptophan) (PEG-PBTrp) diblock copolymers and poly(Nα-Boc-L-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-L-tryptophan) (PBTrp-PEG-PBTrp) triblock copolymers of various molecular weights were synthesised via ring opening chain polymerisation of the NCA terminated Boc protected L-tryptophan amino acid, for the purpose of drug delivery applications.
Biodegradable PEGDA/PHBV network blends via in situ photopolymerization. Blends of crosslinked poly(ethylene glycol) diacrylate (PEGDA) and poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) were prepared via in situ photopolymerization. Chinese hamster ovary cells were cultured on the blend materials, showing good biocompatibility.
Fabrication of porous polymer scaffolds using supercritical carbon dioxide. This work involves the preparation and characterization of porous poly(propylene carbonate) and porous thermoplastic polyurethane/polystyrene blend scaffolds using supercritical carbon dioxide combined with solvent etching. Cell culture experiments were conducted with these porous blend materials to evaluate their potential use as tissue engineering scaffolds.
Effect of crystallization on cell proliferation on PLLA/PDLLA blend films. Crystallization is a common phenomenon in the PLLA/PDLLA blend films. Even in the blend film with only 20 wt% PLLA, semicrystalline morphology was clearly observed. The effect of the composition on the cell proliferation was noticed before in the PLLA/PDLLA blends but the mechanism remained unclear. Our study suggested that crystallization has a predominant influence on the cell proliferation of the PLLA/PDLLA blend films. The crystallization of the thin blend film hinders the fibroblast cell proliferation on the film surface