Prof Aaron Russell

STAFF PROFILE

Position

Associate Head of School (International)

Faculty

Faculty of Health

Department

School of Exer & Nutr Sciences

Campus

Melbourne Burwood Campus

Qualifications

Graduate Certificate of Higher Education, Deakin University, 2008
Doctor of Philosophy, Deakin University, 2001
Bachelor of Applied Science (Human Movement), Deakin University, 1995

Contact

aaron.russell@deakin.edu.au
+61 3 925 17397

Biography summary

2020 - current: Professor, School of Exercise and Nutrition Sciences, Deakin University

2017 - 2020: Pro Vice-Chancellor, Researcher Development and Integrity, Deakin University

2014 - 2017: Professor, School of Exercise and Nutrition Sciences, Deakin University

2011 - 2013 : Associate Professor, School of Exercise and Nutrition Sciences, Deakin University

2011 : Visiting Research Fellow, The Scripps Research Institute, San Diego, USA

2008 - 2011 : NHMRC Research Fellow, School of Exercise and Nutrition Sciences, Deakin University

2006 - 2008 : Senior Lecturer, School of Exercise and Nutrition Sciences, Deakin University

2002 - 2006 : Head of Molecular Physiology, Clinique Romande de readaption, Sion, Switzerland

2000 - 2002 : Research Fellow, Department of Medical Biochemistry, University of Geneva, Switzerland

Research interests

My research group is focused on determining the molecular factors that control skeletal muscle wasting, growth and regeneration. Investigations are performed in humans using in vivo models of muscle wasting including motor neuron disease (MND), muscular dystrophy (DMD and sarcopenia. Acute and chronic exercise protocols are used as models to investigate the signalling proteins that regulate skeletal muscle growth and regeneration.

 

  • In vitro studies are also performed using human primary muscle cells as well as C2C12 and L6 muscle cell lines.

 

  • In vivo rodent models are used to investigate the role of specific molecular targets using AAV and lentiviral technology.

 

  • Research tools include quantitative PCR, Western blotting, EMSA, Luciferase reporter assays, protein degradation and synthesis assays.

 

  • Molecular targets of interest include PGC-1, STARS and several miRNA species.

Conferences

(Invited Presentation - past 5 years)

2018 Molecular Mechanisms of muscle wasting during ageing and disease, Ascona, Italy. MicroRNA inhibition to improve skeletal muscle health in ALS.


2017 American College of Sports Medicine, Denver, USA. Regulation of skeletal muscle miRNAs.


2017 Advances in Skeletal Muscle Biology in Health and Disease Conference, Gainesville, USA. miRNA therapy as an approach to treat ALS.


2016 International Conference of Physiological Sciences, Beijing, China. Molecular regulators of brown adipose tissue and skeletal muscle

Awards


 

Publications

No publications found

Funded Projects at Deakin

Australian Competitive Grants

Molecular targets involved with human muscle atrophy and hypertrophy

Prof Aaron Russell

NHMRC CDF - Career Development Fellowship

  • 2011: $97,768
  • 2010: $96,040
  • 2009: $94,250
  • 2008: $92,500

The role of Notch signalling in muscular dystrophy

Prof Aaron Russell, Prof Gordon Lynch

NHMRC Project Grant

  • 2011: $34,136
  • 2010: $35,890
  • 2009: $37,643

Skeletal muscle CD34+cells as targets to increase energy expenditure and insulin

Prof Aaron Russell

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2011: $58,940

Role of STARS signalling in maintaining skeletal muscle mass and function; implications for our ageing population

Prof Aaron Russell, Prof Gordon Lynch

NHMRC Project Grant

  • 2016: $44,155
  • 2015: $83,226
  • 2014: $68,857
  • 2013: $44,777

Inhibiting microRNA-23 as a therapeutic strategy to treat amyotrophic lateral sclerosis (ALS)

Prof Aaron Russell, A/Prof Roger Chung

Motor Neurone Disease Research Institute of Australia Research Grants

  • 2014: $56,975

Identifying biomarkers from extracellular vesicles for early detection, disease progression and therapeutic efficiency in MND

Prof Aaron Russell, Dr Adam Walker, Dr Suresh Mathivanan, A/Prof Roger Chung

FightMND Impact Grant

  • 2024: $66,909
  • 2021: $124,921
  • 2020: $58,012

Evaluation of a novel inducible muscle-specific TDP-43 mouse model of ALS

Prof Aaron Russell, Dr Adam Walker, A/Prof David Wright

FightMND Impact Grant

  • 2023: $124,996
  • 2022: $64,337

New viral-mediated TDP-43 mouse models of MND

Dr Adam Walker, Dr Marco Morsch, Dr Heledd Brown-Wright, A/Prof Leszek Lisowski, Prof Aaron Russell, Dr Paul Della Gatta

FightMND Impact Grant

  • 2023: $5,000

Other Public Sector Funding

Dermatan sulphate as a nutraceutical for application in the field of muscle growth: the effect of dermatan sulphate on human muscle cells

A/Prof David Cameron-Smith, A/Prof Tim Crowe, Prof Aaron Russell

CSIRO Grant - Research - Commonwealth Scientific and Industrial Research Organisation

  • 2009: $20,000
  • 2008: $80,000

Physiological effects on volunteer fire fighters during fire supression of Australian bushfires

Prof Aaron Russell, Mr Matthew Phillips

CRC_Bushfire Scholarship

  • 2009: $12,500

Exercise Open Treadmill with Shock for Rats and Mice. C-Pace Cell Culture EP stimulator with EHV100.

Prof Aaron Russell

NHMRC - Equipment Grant (pre 2017)

  • 2013: $34,343

Industry and Other Funding

Molecular mechanisms regulating mitochondrial development and function in the skeletal muscle of ALS patients.

Prof Aaron Russell

Assoc Francaise Contre Les Myopathies Grant - Research

  • 2007: $26,503
  • 2006: $26,936

Health benefits of long-term strength training in patients with chronic kidney disease.

Dr Aaron Petersen, Prof L McMahon, Prof Aaron Russell, Dr Gaele Ducher

LEW Carty Charitable Fund Grant - Research

  • 2009: $25,000

Regulation of post-exercise recovery: Understanding the mechanisms of muscle inflammation and repair

Mr Luke Vella, Prof Aaron Russell, Prof Rod Snow

Sports Medicine Australia

  • 2013: $2,000

Rescuing the STARS protein as a treatment for muscular dystrophy

Prof Aaron Russell, Prof Gordon Lynch, Dr Paul Della Gatta

AFM Telethon

  • 2014: $12,440

Utilising a novel research model of motor neurone disease to investigate potential new therapeutic strategies: a proof-of-concept study

Prof Aaron Russell, Dr Torie Foletta, Dr Paul Della Gatta, Dr Rabia Islam

CASS Grant - Research - The CASS Foundation Limited

  • 2019: $11,000
  • 2018: $37,141

Promoting axon regeneration by suppressing miRNA-23a

Dr Rabia Islam, Prof Aaron Russell, Dr Torie Foletta, Dr Paul Della Gatta, Mr Frederico Gerlinger Romero

Brain Foundation

  • 2018: $30,000

Investigating the role of neurturin as a therapeutic strategy to delay ALS disease progression

Prof Aaron Russell, Prof Jorge Ruas, Prof Clinton Bruce, Dr Paul Della Gatta, Dr Angus Lindsay, Dr Angus Lindsay

Motor Neurone Disease Australia Inc (MND Aust)

  • 2023: $100,000

Supervisions

Principal Supervisor
2018

Luke Vella

Thesis entitled: Understanding the Molecular Mechanisms of Post-Exercise Muscle Inflammation and Repair

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2016

Evelyn Zacharewicz

Thesis entitled: The Role of MicroRNAs in Regulating Muscle Protein Synthesis

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2014

Renae Stefanetti

Thesis entitled: Atrogin-1 and MURF-1 signalling in human skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Isabelle Guller

Thesis entitled: MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2013

Craig Wright

Thesis entitled: ROLE AND REGULATION OF G-CSF AND ITS RECEPTOR IN MUSCLE

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Erin Brown

Thesis entitled: The role of PGC-1a and PGC-1b in skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Marita Wallace

Thesis entitled: The role and regulation of stars in skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Patricio Sepulveda

Thesis entitled: Development of Novel interventions to enhance muscle function

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2011

Matthew Phillips

Thesis entitled: Pre-cursors to Physical Employment Standards for Rural Tanker-based Bushfire Suppression Work

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

Executive Supervisor
2020

Kate Sadler

Thesis entitled: Establishing the role of Striated Muscle Activator of Rho Signalling

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Co-supervisor
2021

Stavroula Tsitkanou

Thesis entitled: Investigating pharmacological and non-pharmacological therapeutic approaches in Amyotrophic Lateral Sclerosis

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

Giselle Larissa Allsopp

Thesis entitled: Physiological Responses of Older Adults to Resistance Exercise in Hypoxia.

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2019

Bilal Ahmad Mir

Thesis entitled: The regulation and role of NDRG2 during catabolic stress in skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

Associate Supervisor
2022

Mamatha Philip Gabriel

Thesis entitled: Creatine Metabolism and Supplementation of the Maternal Uterus

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2021

Jasmine Mikovic

Thesis entitled: THE INTRINSIC AND EXTRINSIC FACTORS MODULATING SKELETAL MUSCLE CELL PROLIFERATION

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2018

Anthony May

Thesis entitled: Mechanisms of muscle adaptations to blood flow restriction exercise

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2017

Yasmin Asif

Thesis entitled: Impact of exercise early in life on the adult heart

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2016

Kimberley Catania

Thesis entitled: NDRG2 overexpression effects on skeletal muscle cell growth & stress-response

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2015

Lisa Parkinson

Thesis entitled: The Perceptual and Anti-Inflammatory effects of Oleocanthal, an Olive Oil Phenolic

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2014

Shaun Mason

Thesis entitled: Treatment of Type 2 Diabetes with antioxidant vitamin C therapy

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

2012

James Markworth

Thesis entitled: Inflammatory signaling in skeletal muscle cell growth

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2011

Petra Gran

Thesis entitled: Anabolic Signalling in Skeletal Muscle: Impact of Diet and Disease

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences