A/Prof. Clinton Bruce

STAFF PROFILE

Position

ARC Future Fellow

Faculty

Faculty of Health

Department

School of Exercise & Nut. Sci.

Campus

Melbourne Burwood Campus

Qualifications

Doctor of Philosophy, Royal Melb Inst. of Technology, 2003

Contact

clinton.bruce@deakin.edu.au
+61 3 924 46684

Biography

Dr Bruce received his PhD from RMIT University in 2003 and completed postdoctoral appointments at the University of Guelph, Canada, the Garvan Institute of Medical Research and the Baker IDI Heart and Diabetes Institute. He established an independent laboratory in the Department of Physiology at Monash University in 2012 prior to taking up an academic appointment at Deakin University in 2014. 

Read more on Clinton's profile

Research interests

Dr Bruce’s research is focussed on understanding the regulation of glucose metabolism in skeletal muscle and liver in health and disease. He is particularly interested in identifying mechanisms underlying the development of glucose intolerance and insulin resistance.  He also has an interest in identifying the role of lipids in regulating skeletal muscle function. His research involves the use of stable isotope methodology and GC-MS based metabolomics to measure glucose and lipid fluxes, protein synthesis and mitochondrial biogenesis.

Affiliations

Member of the Australian Physiological Society (AuPS), the Australian Diabetes Society (ADS), American Physiological Society (APS) and the Australian and New Zealand Metabolomics Network (ANZMN)

Knowledge areas

Glucose metabolism, lipid metabolism, insulin resistance, type 2 diabetes, metabolomics, stable isotopes, muscle physiology

Expertise

Insulin resistance, glucose metabolism, hepatic glucose production, skeletal muscle physiology, lipid metabolism, tracers in metabolic research

Awards

2018 Vice Chancellors Award - Mid-Career Researcher Award for Career Excellence

2017-2020 ARC Future Fellowship

2013-2014 Monash Researcher Accelerator Program

2013 Australian Diabetes Society annual meeting Pincus Taft Young Investigator awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).

2012 Australian Diabetes Society annual meeting best basic science poster awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).

2010-2013 NHMRC Career Development Award

2005-2009 NHMRC Peter Doherty Postdoctoral Fellowship

2000-2003 Australian Postgraduate Research Award

Projects

Mechanisms of glucose intolerance and insulin resistance.

The role of membrane lipids in regulating skeletal muscle physiology.

Publications

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2020

The effects of early-onset pre-eclampsia on placental creatine metabolism in the third trimester

S Ellery, P Murthi, P Gatta, A May, M Davies-Tuck, G Kowalski, D Callahan, C Bruce, E Wallace, D Walker, H Dickinson, R Snow

(2020), Vol. 21, pp. 1-14, International journal of molecular sciences, Basel, Switzerland, C1

journal article

Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test

H Beyene, S Hamley, C Giles, K Huynh, A Smith, M Cinel, N Mellet, M Morales-Scholz, D Kloosterman, K Howlett, G Kowalski, C Shaw, D Magliano, C Bruce, P Meikle

(2020), Vol. 105, pp. e1041-e1055, The Journal of clinical endocrinology and metabolism, Oxford, Eng., C1

journal article
2019

Urinary sodium is positively associated with urinary free cortisol and total cortisol metabolites in a cross-sectional sample of Australian schoolchildren aged 5-12 years and their mothers

Susan Torres, Carley Grimes, Caryl Nowson, Sisitha Jayasinghe, Clinton Bruce, Shaun Mason, Feng He, Anne Turner

(2019), Vol. 121, pp. 164-171, British journal of nutrition, Cambridge, Eng., C1

journal article

Postprandial aminogenic insulin and glucagon secretion can stimulate glucose flux in humans

Teddy Ang, Clinton Bruce, Greg Kowalski

(2019), Vol. 68, pp. 939-946, Diabetes, Arlington, Va., C1

journal article

UNICORN babies: understanding circulating and cerebral creatine levels of the preterm infant. An observational study protocol

Mary Berry, Melissa Schlegel, Greg Kowalski, Clinton Bruce, Damien Callahan, Miranda Davies-Tuck, Hayley Dickinson, Angus Goodson, Angie Slocombe, Rod Snow, David Walker, Stacey Ellery

(2019), Vol. 10, pp. 1-8, Frontiers in physiology, Lausanne, Switzerland, C1

journal article

Modest changes to glycemic regulation are sufficient to maintain glucose flux in healthy humans following overfeeding with a habitual macronutrient composition

Dale Morrison, Greg Kowalski, Clinton Bruce, Glenn Wadley

(2019), Vol. 316, pp. E1061-E1070, American journal of physiology. Endocrinology and metabolism, Bethesda, Md., C1

journal article

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling

Lewin Small, Amanda Brandon, Benjamin Parker, Vinita Deshpande, Azrah Samsudeen, Greg Kowalski, Jane Reznick, Donna Wilks, Elaine Preston, Clinton Bruce, David James, Nigel Turner, Gregory Cooney

(2019), Vol. 25, pp. 107-118, Molecular metabolism, Amsterdam, The Netherlands, C1

journal article

Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass

A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce

(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1

journal article

Placental creatine metabolism in cases of placental insufficiency and reduced fetal growth

Stacey Ellery, Padma Murthi, Miranda Davies-Tuck, Paul Della Gatta, Anthony May, Greg Kowalski, Damien Callahan, Clinton Bruce, Nicole Alers, Suzanne Miller, Jan Erwich, Euan Wallace, David Walker, Hayley Dickinson, Rod Snow

(2019), Vol. 25, pp. 495-505, Molecular human reproduction, Oxford, Eng., C1

journal article

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

S Hamley, D Kloosterman, T Duthie, C Dalla Man, R Visentin, S Mason, T Ang, A Selathurai, G Kaur, M Morales-Scholz, K Howlett, G Kowalski, C Shaw, C Bruce

(2019), Vol. 62, pp. 2310-2324, Diabetologia, Berlin, Germany, C1

journal article

Treatment of type 2 diabetes with the designer cytokine IC7Fc

M Findeisen, T Allen, D Henstridge, H Kammoun, A Brandon, L Baggio, K Watt, M Pal, L Cron, E Estevez, C Yang, G Kowalski, L O’Reilly, C Egan, E Sun, L Thai, G Krippner, T Adams, R Lee, J Grötzinger, C Garbers, S Risis, M Kraakman, N Mellet, J Sligar, E Kimber, R Young, M Cowley, C Bruce, P Meikle, P Baldock, P Gregorevic, T Biden, G Cooney, D Keating, D Drucker, S Rose-John, M Febbraio

(2019), Vol. 574, pp. 63-68, Nature, London, Eng., C1

journal article
2018

Effects of breaking up sitting on adolescents' postprandial glucose after consuming meals varying in energy: a cross-over randomised trial

E Fletcher, J Salmon, S McNaughton, L Orellana, G Wadley, C Bruce, P Dempsey, K Lacy, D Dunstan

(2018), Vol. 21, pp. 280-285, Journal of science and medicine in sport, Amsterdam, The Netherlands, C1

journal article

Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans

D Morrison, G Kowalski, E Grespan, A Mari, C Bruce, G Wadley

(2018), Vol. 314, pp. E503-E511, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1

journal article

Perilipin 5 deletion unmasks an endoplasmic reticulum stress-fibroblast growth factor 21 axis in skeletal muscle

Magdalene Montgomery, Ruzaidi Mokhtar, Jacqueline Bayliss, Helena Parkington, Victor Suturin, Clinton Bruce, Matthew Watt

(2018), Vol. 67, pp. 594-606, Diabetes, Arlington, Va., C1

journal article

AgRP neurons require carnitine acetyltransferase to regulate metabolic flexibility and peripheral nutrient partitioning

A Reichenbach, R Stark, M Mequinion, R Denis, J Goularte, R Clarke, S Lockie, M Lemus, G Kowalski, C Bruce, C Huang, R Schittenhelm, R Mynatt, B Oldfield, M Watt, S Luquet, Z Andrews

(2018), Vol. 22, pp. 1745-1759, Cell reports, Amsterdam, The Netherlands, C1

journal article

Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism

Jessica Marshall, Emma Estevez, Helene Kammoun, Emily King, Clinton Bruce, Brian Drew, Hongwei Qian, Peter Iliades, Paul Gregorevic, Mark Febbraio, Darren Henstridge

(2018), Vol. 20, pp. 1928-1936, Diabetes, obesity & metabolism, Chichester, Eng., C1

journal article

Endogenous glucose production following sequential meals in humans: evidence for more prolonged suppression following ingestion of a second meal

Teddy Ang, Greg Kowalski, Clinton Bruce

(2018), Vol. 315, pp. E904-E911, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1

journal article

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Nigel Turner, Xin Lim, Hamish Toop, Brenna Osborne, Amanda Brandon, Elysha Taylor, Corrine Fiveash, Hemna Govindaraju, Jonathan Teo, Holly McEwen, Timothy Couttas, Stephen Butler, Abhirup Das, Greg Kowalski, Clinton Bruce, Kyle Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory Cooney, Magdalene Montgomery, Jonathan Morris, Anthony Don

(2018), Vol. 9, Nature communications, London, Eng., C1

journal article
2017

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

journal article

Creatine biosynthesis and transport by the term human placenta

S Ellery, P Della Gatta, C Bruce, G Kowalski, M Davies-Tuck, J Mockler, P Murthi, D Walker, R Snow, H Dickinson

(2017), Vol. 52, pp. 86-93, Placenta, Amsterdam, The Netherlands, C1

journal article

Does maternal-fetal transfer of creatine occur in pregnant sheep?

S Baharom, R De Matteo, S Ellery, P Della Gatta, C Bruce, G Kowalski, N Hale, H Dickinson, R Harding, D Walker, R Snow

(2017), Vol. 313, pp. E75-E83, American journal of physiology, endocrinology and metabolism, Bethesda, Md., C1

journal article

Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice

G Kowalski, M Kraakman, S Mason, A Murphy, C Bruce

(2017), Vol. 233, pp. 269-279, Journal of endocrinology, Bristol, Eng., C1

journal article

The effect of ingested glucose dose on the suppression of endogenous glucose production in humans

G Kowalski, S Moore, S Hamley, A Selathurai, C Bruce

(2017), Vol. 66, pp. 2400-2406, Diabetes, Arlington County, Va., C1

journal article

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

A Zhuang, F Yap, C Bruce, C Leung, M Plan, M Sullivan, C Herath, D McCarthy, K Sourris, P Kantharidis, M Coughlan, M Febbraio, M Hodson, M Watt, P Angus, B Schulz, J Forbes

(2017), Vol. 7, pp. 1-12, Scientific reports, London, Eng., C1

journal article
2016

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

J Wentworth, G Naselli, K Ngui, G Smyth, R Liu, P O'Brien, C Bruce, J Weir, M Cinel, P Meikle, L Harrison

(2016), Vol. 40, pp. 706-713, International journal of obesity, London, Eng., C1

journal article

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

G Lancaster, H Kammoun, M Kraakman, G Kowalski, C Bruce, M Febbraio

(2016), Vol. 7, pp. 1-10, Nature communications, London, Eng., C1

journal article

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis

G Kowalski, S Hamley, A Selathurai, J Kloehn, D De Souza, S O’Callaghan, B Nijagal, D Tull, M McConville, C Bruce

(2016), Vol. 6, pp. 1-10, Scientific reports, London, Eng., C1

journal article

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Müller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschöp, M Watt, I Clarke, C Roth, K Grove, M Cowley

(2016), Vol. 5, pp. 807-822, Molecular metabolism, Amsterdam, The Netherlands, C1

journal article

Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell reports, New York, N.Y., C1

journal article

Analysis of mammalian cell proliferation and macromolecule synthesis using deuterated water and gas chromatography-mass spectrometry

V Foletta, M Palmieri, J Kloehn, S Mason, S Previs, M McConville, O Sieber, C Bruce, G Kowalski

(2016), Vol. 6, pp. 1-19, Metabolites, Basel, Switzerland, C1

journal article

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

R Lee-Young, N Hoffman, K Murphy, D Henstridge, D Samocha-Bonet, A Siebel, P Iliades, B Zivanovic, Y Hong, T Colgan, M Kraakman, C Bruce, P Gregorevic, G McConell, G Lynch, G Drummond, B Kingwell, J Greenfield, M Febbraio

(2016), Vol. 5, pp. 1083-1091, Molecular Metabolism, Amsterdam, The Netherlands, C1

journal article
2015

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Greg Kowalski, Joachim Kloehn, Micah Burch, Ahrathy Selathurai, Steven Hamley, Stéphanie Bayol, Séverine Lamon, Matthew Watt, Robert Lee-Young, Malcolm McConville, C Bruce

(2015), Vol. 1851, pp. 210-219, Biochimica et Biophysica Acta (BBA)- molecular and cell biology of lipids, Amsterdam, Netherlands, C1

journal article

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

M Kraakman, H Kammoun, T Allen, V Deswaerte, D Henstridge, E Estevez, V Matthews, B Neill, D White, A Murphy, L Peijs, C Yang, S Risis, C Bruce, X-J Du, A Bobik, R Lee-Young, B Kingwell, A Vasanthakumar, W Shi, A Kallies, G Lancaster, S Rose-John, M Febbraio

(2015), Vol. 21, pp. 403-416, Cell metabolism, Amsterdam, The Netherlands, C1-1

journal article

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1

journal article

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse

G Kowalski, D De Souza, M Burch, S Hamley, J Kloehn, A Selathurai, D Tull, S O'Callaghan, M McConville, C Bruce

(2015), Vol. 462, pp. 27-32, Biochemical and Biophysical Research Communications, C1

journal article

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

journal article

In vivo cardiac glucose metabolism in the high-fat fed mouse: comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach

G Kowalski, D De Souza, S Risis, M Burch, S Hamley, J Kloehn, A Selathurai, R Lee-Young, D Tull, S O'Callaghan, M McConville, C Bruce

(2015), Vol. 463, pp. 818-824, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

journal article

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

P Sepulveda, S Lamon, A Hagg, R Thomson, C Winbanks, H Qian, C Bruce, A Russell, P Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

journal article
2014

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio

(2014), Vol. 63, pp. 1881-1894, Diabetes, C1

journal article

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

N Turner, G Cooney, E Kraegen, C Bruce

(2014), Vol. 220, Journal of Endocrinology, C1-1

journal article

Growing healthy muscles to optimise metabolic health into adult life

S Bayol, C Bruce, G Wadley

(2014), Vol. 5, pp. 420-434, Journal of developmental origins of health and disease, Cambridge, United Kingdom, C1

journal article

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

G Kowalski, C Bruce

(2014), Vol. 307, pp. E859-E871, American journal of physiology-endocrinology and metabolism, Bethesda, MD, C1

journal article

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Rachael Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg Kowalski, Nancy Mokbel, Peter Meikle, Clinton Bruce, Matthew Watt

(2014), Vol. 3, pp. 652-663, Molecular metabolism, Amsterdam, Netherlands, C1-1

journal article
2013

Plasma sphingosine-1-phosphate is elevated in obesity

G Kowalski, A Carey, A Selathurai, B Kingwell, C Bruce

(2013), Vol. 8, pp. 1-7, PloS one, San Francisco, Calif., C1-1

journal article

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

B Lindegaard, V Matthews, C Brandt, P Hojman, T Allen, E Estevez, M Watt, C Bruce, O Mortensen, S Syberg, C Rudnicka, J Abildgaard, H Pilegaard, J Hidalgo, S Ditlevsen, T Alsted, A Madsen, B Pedersen, M Febbraio

(2013), Vol. 62, pp. 3064-3074, Diabetes, Alexandria, Vir., C1-1

journal article

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm

S Miura, Y Kai, M Tadaishi, Y Tokutake, K Sakamoto, C Bruce, M Febbraio, K Kita, S Chohnan, O Ezaki

(2013), Vol. 305, pp. E213-E229, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

journal article

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

N Turner, G Kowalski, S Leslie, S Risis, C Yang, R Lee-Young, J Babb, P Meikle, G Lancaster, D Henstridge, P White, E Kraegen, A Marette, G Cooney, M Febbraio, C Bruce

(2013), Vol. 56, pp. 1638-1648, Diabetologia, C1-1

journal article

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

C Bruce, S Risis, J Babb, C Yang, R Lee-Young, D Henstridge, M Febbraio

(2013), Vol. 154, pp. 65-76, Endocrinology, C1-1

journal article

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

J Boon, A Hoy, R Stark, R Brown, R Meex, D Henstridge, S Schenk, P Meikle, J Horowitz, B Kingwell, C Bruce, M Watt

(2013), Vol. 62, pp. 401-410, Diabetes, C1-1

journal article
2012

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

C Bruce, S Risis, J Babb, C Yang, G Kowalski, A Selathurai, R Lee-Young, J Weir, K Yoshioka, Y Takuwa, P Meikle, S Pitson, M Febbraio

(2012), Vol. 61, pp. 3148-3155, Diabetes, C1-1

journal article

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

D Henstridge, C Bruce, C Pang, G Lancaster, T Allen, E Estevez, T Gardner, J Weir, P Meikle, K Lam, A Xu, N Fujii, L Goodyear, M Febbraio

(2012), Vol. 55, pp. 2769-2778, Diabetologia, C1-1

journal article

Regulation of plasma ceramide levels with fatty acid oversupply: Evidence that the liver detects and secretes de novo synthesised ceramide

M Watt, A Barnett, C Bruce, S Schenk, J Horowitz, A Hoy

(2012), Vol. 55, pp. 2741-2746, Diabetologia, C1-1

journal article

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes

Melissa Barber, Steve Risis, Christine Yang, Peter Meikle, Margaret Staples, Mark Febbraio, Clinton Bruce

(2012), Vol. 7, pp. e41456-e41456, PloS one, C1-1

journal article

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

G Lancaster, B Skiba, C Yang, H Nicholls, K Langley, M Chan, C Bruce, G Rewcastle, P Shepherd, M Karin, M Febbraio

(2012), Vol. 442, pp. 723-732, Biochemical Journal, C1-1

journal article
2011

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation

X Gao, Y Liu, D White, Y Su, B Drew, C Bruce, H Kiriazis, Q Xu, N Jennings, A Bobik, M Febbraio, B Kingwell, R Bucala, G Fingerle-Rowson, A Dart, E Morand, X Du

(2011), Vol. 50, pp. 991-999, Journal of Molecular and Cellular Cardiology, C1-1

journal article

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

G Kowalski, H Nicholls, S Risis, N Watson, P Kanellakis, C Bruce, A Bobik, G Lancaster, M Febbraio

(2011), Vol. 54, pp. 888-899, Diabetologia, C1-1

journal article

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation

A Hoy, C Bruce, S Turpin, A Morris, M Febbraio, M Watt

(2011), Vol. 152, pp. 48-58, Endocrinology, C1-1

journal article
2010

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

Todd Mitchell, Nigel Turner, Paul Else, Anthony Hulbert, John Hawley, Jong Lee, Clinton Bruce, Stephen Blanksby

(2010), Vol. 11, pp. 3954-3964, International journal of molecular sciences, C1-1

journal article

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

V Matthews, T Allen, S Risis, M Chan, D Henstridge, N Watson, L Zaffino, J Babb, J Boon, P Meikle, J Jowett, M Watt, J Jansson, C Bruce, M Febbraio

(2010), Vol. 53, pp. 2431-2441, Diabetologia, C1-1

journal article

Erratum: Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness (Molecular Endocrinology (2008) 22, (1200-1212) DOI: 10.1210/me.2007-0485)

M Watt, B Van Denderen, L Castelli, C Bruce, A Hoy, E Kraegen, L Macaulay, B Kemp

(2010), Vol. 24, pp. 1308-, Molecular Endocrinology, C1-1

journal article
2009

Reactive oxygen species enhance insulin sensitivity

Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Clinton Bruce, Benjamin Shields, Beata Skiba, Lisa Ooms, others

(2009), Vol. 10, pp. 260-272, Cell metabolism, C1-1

journal article

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

V Matthews, M Åström, M Chan, C Bruce, K Krabbe, O Prelovsek, T Åkerström, C Yfanti, C Broholm, O Mortensen, M Penkowa, P Hojman, A Zankari, M Watt, H Bruunsgaard, B Pedersen, M Febbraio

(2009), Vol. 52, pp. 1409-1418, Diabetologia, C1-1

journal article

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

A Hoy, A Brandon, N Turner, M Watt, C Bruce, G Cooney, E Kraegen

(2009), Vol. 297, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article

AMP-activated protein kinase and muscle insulin resistance

E Kraegen, C Bruce, B Hegarty, J Ye, N Turner, G Cooney

(2009), Vol. 14, pp. 4658-4672, Frontiers in Bioscience, C1-1

journal article

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

C Bruce, A Hoy, N Turner, M Watt, T Allen, K Carpenter, G Cooney, M Febbraio, E Kraegen

(2009), Vol. 58, pp. 550-558, Diabetes, C1-1

journal article

α2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise

S Miura, Y Kai, Y Kamei, C Bruce, N Kubota, M Febbraio, T Kadowaki, O Ezaki

(2009), Vol. 296, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article
2008

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats

A Holmes, J Mesa, B Neill, J Chung, A Carey, G Steinberg, B Kemp, R Southgate, G Lancaster, C Bruce, M Watt, M Febbraio

(2008), Vol. 198, pp. 367-374, Journal of Endocrinology, C1-1

journal article

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness

M Watt, B Van Denderen, L Castelli, C Bruce, A Hoy, E Kraegen, L Macaulay, B Kemp

(2008), Vol. 22, pp. 1200-1212, Molecular Endocrinology, C1-1

journal article

HSP72 protects against obesity-induced insulin resistance

J Chung, A Nguyen, D Henstridge, A Holmes, M Chan, J Mesa, G Lancaster, R Southgate, C Bruce, S Duffy, I Horvath, R Mestril, M Watt, P Hooper, B Kingwell, L Vigh, A Hevener, M Febbraio

(2008), Vol. 105, pp. 1739-1744, Proceedings of the National Academy of Sciences of the United States of America, C1-1

journal article
2007

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents

N Turner, C Bruce, S Beale, K Hoehn, T So, M Rolph, G Cooney

(2007), Vol. 56, pp. 2085-2092, Diabetes, C1-1

journal article

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

A Hoy, C Bruce, A Cederberg, N Turner, D James, G Cooney, E Kraegen

(2007), Vol. 293, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

C Bruce, C Brolin, N Turner, M Cleasby, F Van Der Leij, G Cooney, E Kraegen

(2007), Vol. 292, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article
2006

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: Effect of interleukin-6 infusion

A Carey, E Petersen, C Bruce, R Southgate, H Pilegaard, J Hawley, B Pedersen, M Febbraio

(2006), Vol. 49, pp. 1000-1007, Diabetologia, C1-1

journal article

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

C Collier, C Bruce, A Smith, G Lopaschuk, D Dyck

(2006), Vol. 291, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

C Bruce, A Thrush, V Mertz, V Bezaire, A Chabowski, G Heigenhauser, D Dyck

(2006), Vol. 291, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article

Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: Essential role in fatty acid oxidation

V Bezaire, C Bruce, G Heigenhauser, N Tandon, J Glatz, J Luiken, A Bonen, L Spriet

(2006), Vol. 290, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article
2005

PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

R Southgate, C Bruce, A Carey, G Steinberg, K Walder, R Monks, M Watt, J Hawley, M Birnbaum, M Febbraio

(2005), Vol. 19, pp. 2072-2074, FASEB Journal, C1-1

journal article

The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects

C Bruce, V Mertz, G Heigenhauser, D Dyck

(2005), Vol. 54, pp. 3154-3160, Diabetes, C1-1

journal article

AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle

A Smith, C Bruce, D Dyck

(2005), Vol. 565, pp. 537-546, Journal of Physiology, C1-1

journal article

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle

A Smith, C Bruce, D Dyck

(2005), Vol. 565, pp. 547-553, Journal of Physiology, C1-1

journal article
2004

The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats

G Wadley, C Bruce, N Konstantopoulos, S Macaulay, K Howlett, J Hawley, D Cameron-Smith

(2004), Vol. 47, pp. 412-419, Diabetologia, C1

journal article

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

Melissa Arkinstall, Clinton Bruce, Sally Clark, Caroline Rickards, Louise Burke, John Hawley

(2004), Vol. 97, pp. 2275-2283, Journal of applied physiology, C1

journal article

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

T Mitchell, N Turner, A Hulbert, P Else, J Hawley, S Jong, C Bruce, S Blanksby

(2004), Vol. 97, pp. 1823-1829, Journal of Applied Physiology, C1-1

journal article

Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats

C Bruce, S Jong, B Kiens, J Hawley

(2004), Vol. 12, pp. 1158-1165, Obesity Research, C1-1

journal article

Cytokine regulation of skeletal muscle fatty acid metabolism: Effect of interleukin-6 and tumor necrosis factor-α

C Bruce, D Dyck

(2004), Vol. 287, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article

Improvements in insulin resistance with exercise training: a lipocentric approach

C Bruce, J Hawley

(2004), Vol. 36, pp. 1196-1201, Medicine and science in sports and exercise, Philadelphia, PA, C1-1

journal article

Interleukin-6 and tumor necrosis factor-α are not increased in patients with Type 2 diabetes: Evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness

A Carey, C Bruce, M Sacchetti, M Anderson, D Olsen, B Saltin, J Hawley, M Febbraio

(2004), Vol. 47, pp. 1029-1037, Diabetologia, C1-1

journal article

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

N Turner, J Lee, C Bruce, T Mitchell, P Else, A Hulbert, J Hawley

(2004), Vol. 96, pp. 974-980, Journal of Applied Physiology, C1-1

journal article

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

C Bruce, A Kriketos, G Cooney, J Hawley

(2004), Vol. 47, pp. 23-30, Diabetologia, C1-1

journal article
2003

Dietary regulation of fat oxidative gene expression in different skeletal muscle fiber types

A McAinch, J Lee, C Bruce, R Tunstall, J Hawley, D Cameron-Smith

(2003), Vol. 11, pp. 1471-1479, Obesity Research, C1

journal article

Muscle Oxidative Capacity Is a Better Predictor of Insulin Sensitivity than Lipid Status

C Bruce, M Anderson, A Carey, D Newman, A Bonen, A Kriketos, G Cooney, J Hawley

(2003), Vol. 88, pp. 5444-5451, Journal of Clinical Endocrinology and Metabolism, C1-1

journal article

Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism

C Bruce, A Carey, J Hawley, M Febbraio

(2003), Vol. 52, pp. 2338-2345, Diabetes, C1-1

journal article
2002

Interaction of exercise and diet on GLUT-4 protein and gene expression in type I and type II rat skeletal muscle

J Lee, C Bruce, R Tunstall, D Cameron-Smith, H Hügel, J Hawley

(2002), Vol. 175, pp. 37-44, Acta Physiologica Scandinavica, C1

journal article

Effect of different protocols of caffeine intake on metabolism and endurance performance

G Cox, B Desbrow, P Montgomery, M Anderson, C Bruce, T Macrides, D Martin, A Moquin, A Roberts, J Hawley, L Burke

(2002), Vol. 93, pp. 990-999, Journal of Applied Physiology, C1-1

journal article

Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle

J Lee, C Bruce, B Spurrell, J Hawley

(2002), Vol. 29, pp. 655-660, Clinical and Experimental Pharmacology and Physiology, C1-1

journal article
2001

Effect of carbohydrate ingestion on metabolism during running and cycling

M Arkinstall, C Bruce, V Nikolopoulos, A Garnham, J Hawley

(2001), Vol. 91, pp. 2125-2134, Journal of Applied Physiology, C1

journal article

Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats

C Bruce, J Lee, J Hawley

(2001), Vol. 91, pp. 1512-1519, Journal of Applied Physiology, C1-1

journal article

Interaction of diet and training on endurance performance in rats

J Lee, C Bruce, L Spriet, J Hawley

(2001), Vol. 86, pp. 499-508, Experimental Physiology, C1-1

journal article
2000

Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion

M Anderson, C Bruce, S Fraser, N Stepto, R Klein, W Hopkins, J Hawley

(2000), Vol. 10, pp. 464-475, International Journal of Sport Nutrition, C1-1

journal article

Enhancement of 2000-m rowing performance after caffeine ingestion

C Bruce, M Anderson, S Fraser, N Stepto, R Klein, W Hopkins, J Hawley

(2000), Vol. 32, pp. 1958-1963, Medicine and science in sports and exercise, Philadelphia, PA, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Activation of HSP72 in skeletal muscle as a therapeutic target for obesity

Prof Mark Febbraio, A/Prof Clinton Bruce, Prof Sean Mcgee, Prof Mark Hargreaves

NHMRC Project Grant

  • 2013: $20,000
  • 2012: $20,000

Sphingosine kinase: a target for obesity-induced insulin resistance

A/Prof Clinton Bruce, Dr Robert Lee-Young

NHMRC Project Grant

  • 2014: $251,815

Understanding the mechanisms of diet-induced defects in hepatic glucose metabolism.

A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2014: $60,000

Targeting hepatic energy expenditure to improve glycaemic control

Dr Greg Kowalski, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $30,000
  • 2014: $30,000

Does mitochondrial dysfunction impair muscle glucose metabolism?

A/Prof Clinton Bruce, Dr Greg Kowalski, Dr Gunveen Kaur

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $60,000

Liver-type pyruvate kinase: a novel anti-hyperglycemic target

Dr Greg Kowalski, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2016: $59,950

The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

Prof Sean Mcgee, A/Prof Clinton Bruce, Prof Forest White, Prof Ken Walder

NHMRC Project Grant

  • 2020: $10,462
  • 2019: $187,097
  • 2018: $181,879
  • 2017: $169,227

Defining a novel pathway in the regulation of skeletal muscle mass

A/Prof Clinton Bruce

ARC Fellowships - Future Fellowships

  • 2020: $108,821
  • 2019: $213,793
  • 2018: $209,631
  • 2017: $308,533

The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy

Prof Sean Mcgee, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2017: $59,962

Mechanisms of insulin resistance in humans

A/Prof Clinton Bruce, Dr Greg Kowalski

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2019: $60,000

Metabolic tug-of-war: deciphering the role of glucagon and insulin under physiologically relevant conditions in humans

Dr Greg Kowalski, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2019: $59,900

Aminogenic insulin-glucagon secretion and action in human insulin resistance

Dr Greg Kowalski, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2020: $60,000

Using 'omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS

Prof Ken Walder, Prof Michael Berk, Dr Chiara Bortolasci, Prof Sean Mcgee, A/Prof Clinton Bruce, Dr Wolf Marx

NHMRC Targeted Call for Research into Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Grant Opportunity

  • 2020: $12,660

Industry and Other Funding

Determination of 6,6-2H glucose enrichment in plasma

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2015: $1,920

Measurement of plasma free fatty acids

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2016: $2,200

Other Funding Sources

Determination of 6,6-2H glucose enrichment in plasma

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2017: $776
  • 2016: $1,520
  • 2015: $1,710

Determination of lipogenesis in liver cancer

A/Prof Clinton Bruce, Dr Greg Kowalski

  • 2016: $4,000

Supervisions

Associate Supervisor
2018

Dale John Morrison

Thesis entitled: Quantification of postprandial glucose flux following endurance exercise training and overfeeding by the triple tracer technique

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences