Prof Clinton Bruce

Insulin sensitivity is preserved in mice made obese by feeding a high starch diet

A Brandon, L Small, T Nguyen, E Suryana, H Gong, C Yassmin, S Hancock, T Pulpitel, S Stonehouse, L Prescott, M Kebede, B Yau, L Quek, G Kowalski, C Bruce, N Turner, G Cooney

(2022), Vol. 11, eLife, England, C1

Autophagy is not involved in lipid accumulation and the development of insulin resistance in skeletal muscle

María Morales-Scholz, Courtney Swinton, Robyn Murphy, Greg Kowalski, Clinton Bruce, Kirsten Howlett, Christopher Shaw

(2021), Vol. 534, pp. 533-539, Biochemical and Biophysical Research Communications, Amsterdam, The Netherlands, C1

Insulin resistance in type 1 diabetes managed with metformin (INTIMET): Study protocol of a double-blind placebo-controlled, randomised trial

J Snaith, D Samocha-Bonet, J Evans, Z Liu, G Kowalski, C Bruce, D Holmes-Walker, J Greenfield

(2021), Vol. 38, Diabetic Medicine, England, C1

Translating glucose tolerance data from mice to humans: Insights from stable isotope labelled glucose tolerance tests

C Bruce, S Hamley, T Ang, K Howlett, C Shaw, G Kowalski

(2021), Vol. 53, Molecular Metabolism, Germany, C1

The effects of early-onset pre-eclampsia on placental creatine metabolism in the third trimester

S Ellery, P Murthi, P Gatta, A May, M Davies-Tuck, G Kowalski, D Callahan, C Bruce, E Wallace, D Walker, H Dickinson, R Snow

(2020), Vol. 21, International Journal of Molecular Sciences, Switzerland, C1

Mapping the associations of the plasma lipidome with insulin resistance and response to an oral glucose tolerance test

H Beyene, S Hamley, C Giles, K Huynh, A Smith, M Cinel, N Mellet, M Morales-Scholz, D Kloosterman, K Howlett, G Kowalski, C Shaw, D Magliano, C Bruce, P Meikle

(2020), Vol. 105, pp. E1041-E1055, Journal of Clinical Endocrinology and Metabolism, United States, C1

Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity

K De Jong, L Hall, M Renton, T Connor, S Martin, G Kowalski, C Shaw, C Bruce, K Howlett, S McGee

(2020), Vol. 42, Molecular Metabolism, Germany, C1

Urinary sodium is positively associated with urinary free cortisol and total cortisol metabolites in a cross-sectional sample of Australian schoolchildren aged 5-12 years and their mothers

S Torres, C Grimes, C Nowson, S Jayasinghe, C Bruce, S Mason, F He, A Turner

(2019), Vol. 121, pp. 164-171, British Journal of Nutrition, England, C1

Postprandial aminogenic insulin and glucagon secretion can stimulate glucose flux in humans

T Ang, C Bruce, G Kowalski

(2019), Vol. 68, pp. 939-946, Diabetes, United States, C1

Unicorn babies: Understanding circulating and cerebral creatine levels of the preterm infant. An observational study protocol

M Berry, M Schlegel, G Kowalski, C Bruce, D Callahan, M Davies-Tuck, H Dickinson, A Goodson, A Slocombe, R Snow, D Walker, S Ellery

(2019), Vol. 10, Frontiers in Physiology, Switzerland, C1

Modest changes to glycemic regulation are sufficient to maintain glucose fluxes in healthy young men following overfeeding with a habitual macronutrient composition

Dale Morrison, Greg Kowalski, Clinton Bruce, Glenn Wadley

(2019), Vol. 316, pp. E1061-E1070, American journal of physiology. Endocrinology and metabolism, Bethesda, Md., C1

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling

L Small, A Brandon, B Parker, V Deshpande, A Samsudeen, G Kowalski, J Reznick, D Wilks, E Preston, C Bruce, D James, N Turner, G Cooney

(2019), Vol. 25, pp. 107-118, Molecular Metabolism, Germany, C1

Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass

A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce

(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1

Placental creatine metabolism in cases of placental insufficiency and reduced fetal growth

S Ellery, P Murthi, M Davies-Tuck, P Della Gatta, A May, G Kowalski, D Callahan, C Bruce, N Alers, S Miller, J Erwich, E Wallace, D Walker, H Dickinson, R Snow

(2019), Vol. 25, pp. 495-505, Molecular Human Reproduction, England, C1

Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

S Hamley, D Kloosterman, T Duthie, C Dalla Man, R Visentin, S Mason, T Ang, A Selathurai, G Kaur, M Morales-Scholz, K Howlett, G Kowalski, C Shaw, C Bruce

(2019), Vol. 62, pp. 2310-2324, Diabetologia, Berlin, Germany, C1

Treatment of type 2 diabetes with the designer cytokine IC7Fc

M Findeisen, T Allen, D Henstridge, H Kammoun, A Brandon, L Baggio, K Watt, M Pal, L Cron, E Estevez, C Yang, G Kowalski, L O’Reilly, C Egan, E Sun, L Thai, G Krippner, T Adams, R Lee, J Grötzinger, C Garbers, S Risis, M Kraakman, N Mellet, J Sligar, E Kimber, R Young, M Cowley, C Bruce, P Meikle, P Baldock, P Gregorevic, T Biden, G Cooney, D Keating, D Drucker, S Rose-John, M Febbraio

(2019), Vol. 574, pp. 63-68, Nature, England, C1

Effects of breaking up sitting on adolescents' postprandial glucose after consuming meals varying in energy: a cross-over randomised trial

E Fletcher, J Salmon, S McNaughton, L Orellana, G Wadley, C Bruce, P Dempsey, K Lacy, D Dunstan

(2018), Vol. 21, pp. 280-285, Journal of science and medicine in sport, Amsterdam, The Netherlands, C1

Measurement of postprandial glucose fluxes in response to acute and chronic endurance exercise in healthy humans

D Morrison, G Kowalski, E Grespan, A Mari, C Bruce, G Wadley

(2018), Vol. 314, pp. E503-E511, American Journal of Physiology - Endocrinology and Metabolism, United States, C1

Perilipin 5 deletion unmasks an endoplasmic reticulum Stress-Fibroblast growth factor 21 axis in skeletal muscle

M Montgomery, R Mokhtar, J Bayliss, H Parkington, V Suturin, C Bruce, M Watt

(2018), Vol. 67, pp. 594-606, Diabetes, United States, C1

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

A Reichenbach, R Stark, M Mequinion, R Denis, J Goularte, R Clarke, S Lockie, M Lemus, G Kowalski, C Bruce, C Huang, R Schittenhelm, R Mynatt, B Oldfield, M Watt, S Luquet, Z Andrews

(2018), Vol. 22, pp. 1745-1759, Cell Reports, United States, C1

Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism

J Marshall, E Estevez, H Kammoun, E King, C Bruce, B Drew, H Qian, P Iliades, P Gregorevic, M Febbraio, D Henstridge

(2018), Vol. 20, pp. 1928-1936, Diabetes, Obesity and Metabolism, England, C1

Endogenous glucose production after sequential meals in humans: Evidence for more prolonged suppression after ingestion of a second meal

Teddy Ang, Greg Kowalski, Clinton Bruce

(2018), Vol. 315, pp. E904-E911, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

N Turner, X Lim, H Toop, B Osborne, A Brandon, E Taylor, C Fiveash, H Govindaraju, J Teo, H McEwen, T Couttas, S Butler, A Das, G Kowalski, C Bruce, K Hoehn, T Fath, C Schmitz-Peiffer, G Cooney, M Montgomery, J Morris, A Don

(2018), Vol. 9, Nature Communications, England, C1

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

Creatine biosynthesis and transport by the term human placenta

S Ellery, P Della Gatta, C Bruce, G Kowalski, M Davies-Tuck, J Mockler, P Murthi, D Walker, R Snow, H Dickinson

(2017), Vol. 52, pp. 86-93, Placenta, Amsterdam, The Netherlands, C1

Does maternal-fetal transfer of creatine occur in pregnant sheep?

S Baharom, R De Matteo, S Ellery, P Della Gatta, C Bruce, G Kowalski, N Hale, H Dickinson, R Harding, D Walker, R Snow

(2017), Vol. 313, pp. E75-E83, American Journal of Physiology - Endocrinology and Metabolism, United States, C1

Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice

G Kowalski, M Kraakman, S Mason, A Murphy, C Bruce

(2017), Vol. 233, pp. 269-279, Journal of endocrinology, Bristol, Eng., C1

The effect of ingested glucose dose on the suppression of endogenous glucose production in humans

G Kowalski, S Moore, S Hamley, A Selathurai, C Bruce

(2017), Vol. 66, pp. 2400-2406, Diabetes, United States, C1

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

A Zhuang, F Yap, C Bruce, C Leung, M Plan, M Sullivan, C Herath, D McCarthy, K Sourris, P Kantharidis, M Coughlan, M Febbraio, M Hodson, M Watt, P Angus, B Schulz, J Forbes

(2017), Vol. 7, Scientific Reports, England, C1

G M3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

J Wentworth, G Naselli, K Ngui, G Smyth, R Liu, P O'Brien, C Bruce, J Weir, M Cinel, P Meikle, L Harrison

(2016), Vol. 40, pp. 706-713, International Journal of Obesity, England, C1

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

G Lancaster, H Kammoun, M Kraakman, G Kowalski, C Bruce, M Febbraio

(2016), Vol. 7, Nature Communications, England, C1

Reversing diet-induced metabolic dysregulation by diet switching leads to altered hepatic de novo lipogenesis and glycerolipid synthesis

G Kowalski, S Hamley, A Selathurai, J Kloehn, D De Souza, S O'Callaghan, B Nijagal, D Tull, M McConville, C Bruce

(2016), Vol. 6, Scientific Reports, England, C1

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Müller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschöp, M Watt, I Clarke, C Roth, K Grove, M Cowley

(2016), Vol. 5, pp. 807-822, Molecular Metabolism, Germany, C1

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell Reports, United States, C1

Analysis of mammalian cell proliferation and macromolecule synthesis using deuteratedwater and gas chromatography-mass spectrometry

V Foletta, M Palmieri, J Kloehn, S Mason, S Previs, M McConville, O Sieber, C Bruce, G Kowalski

(2016), Vol. 6, Metabolites, Switzerland, C1

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

R Lee-Young, N Hoffman, K Murphy, D Henstridge, D Samocha-Bonet, A Siebel, P Iliades, B Zivanovic, Y Hong, T Colgan, M Kraakman, C Bruce, P Gregorevic, G McConell, G Lynch, G Drummond, B Kingwell, J Greenfield, M Febbraio

(2016), Vol. 5, pp. 1083-1091, Molecular Metabolism, Amsterdam, The Netherlands, C1

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Greg Kowalski, Joachim Kloehn, Micah Burch, Ahrathy Selathurai, Steven Hamley, Stéphanie Bayol, Séverine Lamon, Matthew Watt, Robert Lee-Young, Malcolm McConville, C Bruce

(2015), Vol. 1851, pp. 210-219, Biochimica et Biophysica Acta (BBA)- molecular and cell biology of lipids, Amsterdam, Netherlands, C1

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

M Kraakman, H Kammoun, T Allen, V Deswaerte, D Henstridge, E Estevez, V Matthews, B Neill, D White, A Murphy, L Peijs, C Yang, S Risis, C Bruce, X-J Du, A Bobik, R Lee-Young, B Kingwell, A Vasanthakumar, W Shi, A Kallies, G Lancaster, S Rose-John, M Febbraio

(2015), Vol. 21, pp. 403-416, Cell metabolism, Amsterdam, The Netherlands, C1-1

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1

Application of dynamic metabolomics to examine in vivo skeletal muscle glucose metabolism in the chronically high-fat fed mouse

G Kowalski, D De Souza, M Burch, S Hamley, J Kloehn, A Selathurai, D Tull, S O'Callaghan, M McConville, C Bruce

(2015), Vol. 462, pp. 27-32, Biochemical and Biophysical Research Communications, United States, C1

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

In vivo cardiac glucose metabolism in the high-fat fed mouse: comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach

G Kowalski, D De Souza, S Risis, M Burch, S Hamley, J Kloehn, A Selathurai, R Lee-Young, D Tull, S O'Callaghan, M McConville, C Bruce

(2015), Vol. 463, pp. 818-824, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

P Sepulveda, S Lamon, A Hagg, R Thomson, C Winbanks, H Qian, C Bruce, A Russell, P Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio

(2014), pp. 1-1, Diabetes, Alexandria, Virginia, C1

Fatty acid metabolism, energy expenditure and insulin resistance in muscle

N Turner, G Cooney, E Kraegen, C Bruce

(2014), Vol. 220, Journal of endocrinology, Bristol, England, C1-1

Growing healthy muscles to optimise metabolic health into adult life

S Bayol, C Bruce, G Wadley

(2014), Vol. 5, pp. 420-434, Journal of developmental origins of health and disease, Cambridge, United Kingdom, C1

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

G Kowalski, C Bruce

(2014), Vol. 307, pp. E859-E871, American journal of physiology-endocrinology and metabolism, Bethesda, MD, C1

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Rachael Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg Kowalski, Nancy Mokbel, Peter Meikle, Clinton Bruce, Matthew Watt

(2014), Vol. 3, pp. 652-663, Molecular metabolism, Amsterdam, Netherlands, C1-1

Plasma sphingosine-1-phosphate is elevated in obesity

G Kowalski, A Carey, A Selathurai, B Kingwell, C Bruce

(2013), Vol. 8, pp. 1-7, PloS one, San Francisco, Calif., C1-1

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

B Lindegaard, V Matthews, C Brandt, P Hojman, T Allen, E Estevez, M Watt, C Bruce, O Mortensen, S Syberg, C Rudnicka, J Abildgaard, H Pilegaard, J Hidalgo, S Ditlevsen, T Alsted, A Madsen, B Pedersen, M Febbraio

(2013), Vol. 62, pp. 3064-3074, Diabetes, Alexandria, Vir., C1-1

Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm

S Miura, Y Kai, M Tadaishi, Y Tokutake, K Sakamoto, C Bruce, M Febbraio, K Kita, S Chohnan, O Ezaki

(2013), Vol. 305, pp. E213-E229, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

N Turner, G Kowalski, S Leslie, S Risis, C Yang, R Lee-Young, J Babb, P Meikle, G Lancaster, D Henstridge, P White, E Kraegen, A Marette, G Cooney, M Febbraio, C Bruce

(2013), Vol. 56, pp. 1638-1648, Diabetologia, Berlin, Germany, C1-1

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

C Bruce, S Risis, J Babb, C Yang, R Lee-Young, D Henstridge, M Febbraio

(2013), Vol. 154, pp. 65-76, Endocrinology, Washington, DC, C1-1

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

J Boon, A Hoy, R Stark, R Brown, R Meex, D Henstridge, S Schenk, P Meikle, J Horowitz, B Kingwell, C Bruce, M Watt

(2013), Vol. 62, pp. 401-410, Diabetes, Alexandria, Virginia, C1-1

Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

C Bruce, S Risis, J Babb, C Yang, G Kowalski, A Selathurai, R Lee-Young, J Weir, K Yoshioka, Y Takuwa, P Meikle, S Pitson, M Febbraio

(2012), Vol. 61, pp. 3148-3155, Diabetes, Alexandria, Virginia, C1-1

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

D Henstridge, C Bruce, C Pang, G Lancaster, T Allen, E Estevez, T Gardner, J Weir, P Meikle, K Lam, A Xu, N Fujii, L Goodyear, M Febbraio

(2012), Vol. 55, pp. 2769-2778, Diabetologia, Berlin, Germany, C1-1

Regulation of plasma ceramide levels with fatty acid oversupply : evidence that the liver detects and secretes de novo synthesised ceramide

M Watt, A Barnett, C Bruce, S Schenk, J Horowitz, A Hoy

(2012), Vol. 55, pp. 2741-2746, Diabetologia, Berlin, Germany, C1-1

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes

Melissa Barber, Steve Risis, Christine Yang, Peter Meikle, Margaret Staples, Mark Febbraio, Clinton Bruce

(2012), Vol. 7, pp. e41456-e41456, PloS one, C1-1

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

G Lancaster, B Skiba, C Yang, H Nicholls, K Langley, M Chan, C Bruce, G Rewcastle, P Shepherd, M Karin, M Febbraio

(2012), Vol. 442, pp. 723-732, Biochemical journal, London, England, C1-1

Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury : a predominant role of anti-inflammation

X Gao, Y Liu, D White, Y Su, B Drew, C Bruce, H Kiriazis, Q Xu, N Jennings, A Bobik, M Febbraio, B Kingwell, R Bucala, G Fingerle-Rowson, A Dart, E Morand, X Du

(2011), Vol. 50, pp. 991-999, Journal of molecular and cellular cardiology, Amsterdam, The Netherlands, C1-1

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

G Kowalski, H Nicholls, S Risis, N Watson, P Kanellakis, C Bruce, A Bobik, G Lancaster, M Febbraio

(2011), Vol. 54, pp. 888-899, Diabetologia, Berlin, Germany, C1-1

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation

A Hoy, C Bruce, S Turpin, A Morris, M Febbraio, M Watt

(2011), Vol. 152, pp. 48-58, Endocrinology, Washington, DC, C1-1

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

Todd Mitchell, Todd Mitchell, Nigel Turner, Nigel Turner, Paul Else, Paul Else, Anthony Hulbert, Anthony Hulbert, John Hawley, John Hawley, Jong Lee, Jong Lee, Clinton Bruce, Clinton Bruce, Stephen Blanksby, Stephen Blanksby

(2010), Vol. 11, pp. 3954-3964, International journal of molecular sciences, C1-1

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

V Matthews, V Matthews, T Allen, T Allen, S Risis, S Risis, M Chan, M Chan, D Henstridge, D Henstridge, N Watson, N Watson, L Zaffino, L Zaffino, J Babb, J Babb, J Boon, J Boon, P Meikle, P Meikle, J Jowett, J Jowett, M Watt, M Watt, J Jansson, J Jansson, C Bruce, C Bruce, M Febbraio, M Febbraio

(2010), Vol. 53, pp. 2431-2441, Diabetologia, Berlin, Germany, C1-1

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness (Molecular Endocrinology (2008) 22, (1200-1212) DOI: 10.1210/me.2007-0485) erratum

M Watt, D Van, L Castelli, C Bruce, A Hoy, E Kraegen, L Macaulay, B Kemp

(2010), Vol. 24, pp. 1308-1308, Molecular endocrinology, Washington, DC, C1-1

Reactive oxygen species enhance insulin sensitivity

Kim Loh, Kim Loh, Haiyang Deng, Haiyang Deng, Atsushi Fukushima, Atsushi Fukushima, Xiaochu Cai, Xiaochu Cai, Benoit Boivin, Benoit Boivin, Sandra Galic, Sandra Galic, Clinton Bruce, Clinton Bruce, Benjamin Shields, Benjamin Shields, Beata Skiba, Beata Skiba, Lisa Ooms, Lisa Ooms, others, others

(2009), Vol. 10, pp. 260-272, Cell metabolism, C1-1

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

V Matthews, V Matthews, M Aström, M Aström, M Chan, M Chan, C Bruce, C Bruce, K Krabbe, K Krabbe, O Prelovsek, O Prelovsek, T Akerström, T Akerström, C Yfanti, C Yfanti, C Broholm, C Broholm, O Mortensen, O Mortensen, M Penkowa, M Penkowa, P Hojman, P Hojman, A Zankari, A Zankari, M Watt, M Watt, H Bruunsgaard, H Bruunsgaard, B Pedersen, B Pedersen, M Febbraio, M Febbraio

(2009), Vol. 52, pp. 1409-1418, Diabetologia, Berlin, Germany, C1-1

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt or AS160 phosphorylation

A Hoy, A Hoy, A Brandon, A Brandon, N Turner, N Turner, M Watt, M Watt, C Bruce, C Bruce, G Cooney, G Cooney, E Kraegen, E Kraegen

(2009), Vol. 297, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1

AMP-activated protein kinase and muscle insulin resistance

E Kraegen, E Kraegen, C Bruce, C Bruce, B Hegarty, B Hegarty, J Ye, J Ye, N Turner, N Turner, G Cooney, G Cooney

(2009), Vol. 14, pp. 4658-4672, Frontiers in bioscience, Irvine, California, C1-1

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

C Bruce, C Bruce, A Hoy, A Hoy, N Turner, N Turner, M Watt, M Watt, T Allen, T Allen, K Carpenter, K Carpenter, G Cooney, G Cooney, M Febbraio, M Febbraio, E Kraegen, E Kraegen

(2009), Vol. 58, pp. 550-558, Diabetes, Alexandria, Virginia, C1-1

α2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise

S Miura, S Miura, Y Kai, Y Kai, Y Kamei, Y Kamei, C Bruce, C Bruce, N Kubota, N Kubota, M Febbraio, M Febbraio, T Kadowaki, T Kadowaki, O Ezaki, O Ezaki

(2009), Vol. 296, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARα and UCP2 expression in rats

A Holmes, A Holmes, J Mesa, J Mesa, B Neill, B Neill, J Chung, J Chung, A Carey, A Carey, G Steinberg, G Steinberg, B Kemp, B Kemp, R Southgate, R Southgate, G Lancaster, G Lancaster, C Bruce, C Bruce, M Watt, M Watt, M Febbraio, M Febbraio

(2008), Vol. 198, pp. 367-374, Journal of endocrinology, Bristol, England, C1-1

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness

M Watt, M Watt, B Van Denderen, B Van Denderen, L Castelli, L Castelli, C Bruce, C Bruce, A Hoy, A Hoy, E Kraegen, E Kraegen, L Macaulay, L Macaulay, B Kemp, B Kemp

(2008), Vol. 22, pp. 1200-1212, Molecular endocrinology, Washington, DC, C1-1

HSP72 protects against obesity-induced insulin resistance

J Chung, J Chung, A Nguyen, A Nguyen, D Henstridge, D Henstridge, A Holmes, A Holmes, M Chan, M Chan, J Mesa, J Mesa, G Lancaster, G Lancaster, R Southgate, R Southgate, C Bruce, C Bruce, S Duffy, S Duffy, I Horvath, I Horvath, R Mestril, R Mestril, M Watt, M Watt, P Hooper, P Hooper, B Kingwell, B Kingwell, L Vigh, L Vigh, A Hevener, A Hevener, M Febbraio, M Febbraio

(2008), Vol. 105, pp. 1739-1744, Proceedings of the National Academy of Sciences of the United States of America, Washington, DC, C1-1

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents

N Turner, N Turner, C Bruce, C Bruce, S Beale, S Beale, K Hoehn, K Hoehn, T So, T So, M Rolph, M Rolph, G Cooney, G Cooney

(2007), Vol. 56, pp. 2085-2092, Diabetes, Alexandria, Va, C1-1

Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation

A Hoy, A Hoy, C Bruce, C Bruce, A Cederberg, A Cederberg, N Turner, N Turner, D James, D James, G Cooney, G Cooney, E Kraegen, E Kraegen

(2007), Vol. 293, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification

C Bruce, C Bruce, C Brolin, C Brolin, N Turner, N Turner, M Cleasby, M Cleasby, R van der Leij Feike, R van der Leij Feike, G Cooney, G Cooney, E Kraegen, E Kraegen

(2007), Vol. 292, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

Discordant gene expression in skeletal muscle and adipose tissue of patients with type 2 diabetes: effect of interleukin-6 infusion

A Carey, A Carey, E Petersen, E Petersen, C Bruce, C Bruce, R Southgate, R Southgate, H Pilegaard, H Pilegaard, J Hawley, J Hawley, B Pedersen, B Pedersen, M Febbraio, M Febbraio

(2006), Vol. 49, pp. 1000-1007, Diabetologia, Heidelberg, Germany, C1-1

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

C Collier, C Collier, C Bruce, C Bruce, A Smith, A Smith, G Lopaschuk, G Lopaschuk, D Dyck, D Dyck

(2006), Vol. 291, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

C Bruce, C Bruce, A Thrush, A Thrush, V Mertz, V Mertz, V Bezaire, V Bezaire, A Chabowski, A Chabowski, G Heigenhauser, G Heigenhauser, D Dyck, D Dyck

(2006), Vol. 291, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation

V Bezaire, V Bezaire, C Bruce, C Bruce, G Heigenhauser, G Heigenhauser, N Tandon, N Tandon, J Glatz, J Glatz, J Luiken, J Luiken, A Bonen, A Bonen, L Spriet, L Spriet

(2006), Vol. 290, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

R Southgate, C Bruce, A Carey, G Steinberg, K Walder, R Monks, M Watt, J Hawley, M Birnbaum, M Febbraio

(2005), Vol. 19, pp. 2072-2074, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1

The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects

C Bruce, C Bruce, V Mertz, V Mertz, G Heigenhauser, G Heigenhauser, D Dyck, D Dyck

(2005), Vol. 54, pp. 3154-3160, Diabetes, Alexandria, Va, C1-1

AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle

A Smith, A Smith, C Bruce, C Bruce, D Dyck, D Dyck

(2005), Vol. 565, pp. 537-546, Journal of physiology, West Sussex, England, C1-1

AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle

A Smith, A Smith, C Bruce, C Bruce, D Dyck, D Dyck

(2005), Vol. 565, pp. 547-553, Journal of physiology, West Sussex, England, C1-1

The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats.

G Wadley, C Bruce, N Konstantopoulos, J Macauley, K Howlett, J Hawley, D Cameron-Smith

(2004), Vol. 47, pp. 412-419, Diabetologia, Berlin, Germany, C1

Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity

Melissa Arkinstall, Clinton Bruce, Sally Clark, Caroline Rickards, Louise Burke, John Hawley

(2004), Vol. 97, pp. 2275-2283, Journal of applied physiology, C1

Exercise alters the profile of phospholipid molecular species in rat skeletal muscle

T Mitchell, T Mitchell, N Turner, N Turner, A Hulbert, A Hulbert, P Else, P Else, J Hawley, J Hawley, J Lee, J Lee, C Bruce, C Bruce, S Blanksby, S Blanksby

(2004), Vol. 97, pp. 1823-1829, Journal of applied physiology, Bethesda, Md., C1-1

Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats

C Bruce, C Bruce, J Lee, J Lee, B Kiens, B Kiens, J Hawley, J Hawley

(2004), Vol. 12, pp. 1158-1165, Obesity research, Hoboken, N.J., C1-1

Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-α

C Bruce, C Bruce, D Dyck, D Dyck

(2004), Vol. 287, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1

Improvements in insulin resistance with exercise training: a lipocentric approach

C Bruce, C Bruce, J Hawley, J Hawley

(2004), Vol. 36, pp. 1196-1201, Medicine and science in sports and exercise, Philadelphia, PA, C1-1

Interleukin-6 and tumor necrosis factor-α are not increased in patients with type 2 diabetes: Evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness

A Carey, A Carey, C Bruce, C Bruce, M Sacchetti, M Sacchetti, M Anderson, M Anderson, D Olsen, D Olsen, B Saltin, B Saltin, J Hawley, J Hawley, M Febbraio, M Febbraio

(2004), Vol. 47, pp. 1029-1037, Diabetologia, Heidelberg, Germany, C1-1

Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

N Turner, N Turner, J Lee, J Lee, C Bruce, C Bruce, T Mitchell, T Mitchell, P Else, P Else, A Hulbert, A Hulbert, J Hawley, J Hawley

(2004), Vol. 96, pp. 974-980, Journal of applied physiology, Bethesda, Md., C1-1

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

C Bruce, C Bruce, A Kriketos, A Kriketos, G Cooney, G Cooney, J Hawley, J Hawley

(2004), Vol. 47, pp. 23-30, Diabetologia, Heidelberg, Germany, C1-1

Dietary regulation of fat oxidative gene expression in different skeletal musle fiber types

A McAinch, J Lee, C Bruce, R Tunstall, J Hawley, D Cameron-Smith

(2003), Vol. 11, pp. 1471-1479, Obesity research, Baton Rouge, La., C1

Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status

C Bruce, C Bruce, M Anderson, M Anderson, A Carey, A Carey, D Newman, D Newman, A Bonen, A Bonen, A Kriketos, A Kriketos, G Cooney, G Cooney, J Hawley, J Hawley

(2003), Vol. 88, pp. 5444-5451, Journal of clinical endocrinology and metabolism, Washington, DC, C1-1

Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism

C Bruce, C Bruce, A Carey, A Carey, J Hawley, J Hawley, M Febbraio, M Febbraio

(2003), Vol. 52, pp. 2338-2345, Diabetes, Alexandria, Va, C1-1

Interaction of exercise and diet on GLUT-4 protein and gene expression in type I and type II rat skeletal muscle

J Lee, C Bruce, R Tunstall, D Cameron-Smith, H Hugel, J Hawley

(2002), Vol. 175, pp. 37-44, Acta physiologica Scandinavica, Oxford, England, C1

Effect of different protocols of caffeine intake on metabolism and endurance performance

G Cox, G Cox, B Desbrow, B Desbrow, P Montgomery, P Montgomery, M Anderson, M Anderson, C Bruce, C Bruce, T Macrides, T Macrides, D Martin, D Martin, A Moquin, A Moquin, A Roberts, A Roberts, J Hawley, J Hawley, L Burke, L Burke

(2002), Vol. 93, pp. 990-999, Journal of applied physiology, Bethesda, Md., C1-1

Effect of training on activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase pathways in rat soleus muscle

J Lee, J Lee, C Bruce, C Bruce, B Spurrell, B Spurrell, J Hawley, J Hawley

(2002), Vol. 29, pp. 655-660, Clinical and experimental pharmacology and physiology, Richmond, VIC, C1-1

Effect of carbohydrate ingestion on metabolism during running and cycling

M Arkinstall, C Bruce, V Nikolopoulos, A Garnham, J Hawley

(2001), Vol. 91, pp. 2125-2134, Journal of applied physiology, Bethesada, Md., C1

Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats

C Bruce, C Bruce, J Lee, J Lee, J Hawley, J Hawley

(2001), Vol. 91, pp. 1512-1519, Journal of applied physiology, Bethesda, Md., C1-1

Interaction of diet and training on endurance performance in rats

J Lee, J Lee, C Bruce, C Bruce, L Spriet, L Spriet, J Hawley, J Hawley

(2001), Vol. 86, pp. 499-508, Experimental physiology, West Sussex, England, C1-1

Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion

M Anderson, M Anderson, C Bruce, C Bruce, S Fraser, S Fraser, N Stepto, N Stepto, R Klein, R Klein, W Hopkins, W Hopkins, J Hawley, J Hawley

(2000), Vol. 10, pp. 464-475, International journal of sport nutrition and exercise metabolism, Champaign, IL, C1-1

Enhancement of 2000-m rowing performance after caffeine ingestion

C Bruce, C Bruce, M Anderson, M Anderson, S Fraser, S Fraser, N Stepto, N Stepto, R Klein, R Klein, W Hopkins, W Hopkins, J Hawley, J Hawley

(2000), Vol. 32, pp. 1958-1963, Medicine and science in sports and exercise, Philadelphia, PA, C1-1