Biography
Dr Bruce received his PhD from RMIT University in 2003 and completed postdoctoral appointments at the University of Guelph, Canada, the Garvan Institute of Medical Research and the Baker IDI Heart and Diabetes Institute. He established an independent laboratory in the Department of Physiology at Monash University in 2012 prior to taking up an academic appointment at Deakin University in 2014.
Read more on Clinton's profileResearch interests
Dr Bruce’s research is focussed on understanding the regulation of glucose metabolism in skeletal muscle and liver in health and disease. He is particularly interested in identifying mechanisms underlying the development of glucose intolerance and insulin resistance. He also has an interest in identifying the role of lipids in regulating skeletal muscle function. His research involves the use of stable isotope methodology and GC-MS based metabolomics to measure glucose and lipid fluxes, protein synthesis and mitochondrial biogenesis.
Affiliations
Member of the Australian Physiological Society (AuPS), the Australian Diabetes Society (ADS), American Physiological Society (APS) and the Australian and New Zealand Metabolomics Network (ANZMN)
Knowledge areas
Glucose metabolism, lipid metabolism, insulin resistance, type 2 diabetes, metabolomics, stable isotopes, muscle physiology
Awards
2018 Vice Chancellors Award - Mid-Career Researcher Award for Career Excellence
2017-2020 ARC Future Fellowship
2013-2014 Monash Researcher Accelerator Program
2013 Australian Diabetes Society annual meeting Pincus Taft Young Investigator awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).
2012 Australian Diabetes Society annual meeting best basic science poster awarded to Dr. Greg Kowalski (postdoctoral fellow in my laboratory).
2010-2013 NHMRC Career Development Award
2005-2009 NHMRC Peter Doherty Postdoctoral Fellowship
2000-2003 Australian Postgraduate Research Award
Projects
Mechanisms of glucose intolerance and insulin resistance.
The role of membrane lipids in regulating skeletal muscle physiology.
Publications
Insulin sensitivity is preserved in mice made obese by feeding a high starch diet
A Brandon, L Small, T Nguyen, E Suryana, H Gong, C Yassmin, S Hancock, T Pulpitel, S Stonehouse, L Prescott, M Kebede, B Yau, L Quek, G Kowalski, C Bruce, N Turner, G Cooney
(2022), Vol. 11, eLife, England, C1
María Morales-Scholz, Courtney Swinton, Robyn Murphy, Greg Kowalski, Clinton Bruce, Kirsten Howlett, Christopher Shaw
(2021), Vol. 534, pp. 533-539, Biochemical and Biophysical Research Communications, Amsterdam, The Netherlands, C1
J Snaith, D Samocha-Bonet, J Evans, Z Liu, G Kowalski, C Bruce, D Holmes-Walker, J Greenfield
(2021), Vol. 38, Diabetic Medicine, England, C1
C Bruce, S Hamley, T Ang, K Howlett, C Shaw, G Kowalski
(2021), Vol. 53, Molecular Metabolism, Germany, C1
The effects of early-onset pre-eclampsia on placental creatine metabolism in the third trimester
S Ellery, P Murthi, P Gatta, A May, M Davies-Tuck, G Kowalski, D Callahan, C Bruce, E Wallace, D Walker, H Dickinson, R Snow
(2020), Vol. 21, International Journal of Molecular Sciences, Switzerland, C1
H Beyene, S Hamley, C Giles, K Huynh, A Smith, M Cinel, N Mellet, M Morales-Scholz, D Kloosterman, K Howlett, G Kowalski, C Shaw, D Magliano, C Bruce, P Meikle
(2020), Vol. 105, pp. E1041-E1055, Journal of Clinical Endocrinology and Metabolism, United States, C1
K De Jong, L Hall, M Renton, T Connor, S Martin, G Kowalski, C Shaw, C Bruce, K Howlett, S McGee
(2020), Vol. 42, Molecular Metabolism, Germany, C1
S Torres, C Grimes, C Nowson, S Jayasinghe, C Bruce, S Mason, F He, A Turner
(2019), Vol. 121, pp. 164-171, British Journal of Nutrition, England, C1
Postprandial aminogenic insulin and glucagon secretion can stimulate glucose flux in humans
T Ang, C Bruce, G Kowalski
(2019), Vol. 68, pp. 939-946, Diabetes, United States, C1
M Berry, M Schlegel, G Kowalski, C Bruce, D Callahan, M Davies-Tuck, H Dickinson, A Goodson, A Slocombe, R Snow, D Walker, S Ellery
(2019), Vol. 10, Frontiers in Physiology, Switzerland, C1
Dale Morrison, Greg Kowalski, Clinton Bruce, Glenn Wadley
(2019), Vol. 316, pp. E1061-E1070, American journal of physiology. Endocrinology and metabolism, Bethesda, Md., C1
L Small, A Brandon, B Parker, V Deshpande, A Samsudeen, G Kowalski, J Reznick, D Wilks, E Preston, C Bruce, D James, N Turner, G Cooney
(2019), Vol. 25, pp. 107-118, Molecular Metabolism, Germany, C1
A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce
(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1
Placental creatine metabolism in cases of placental insufficiency and reduced fetal growth
S Ellery, P Murthi, M Davies-Tuck, P Della Gatta, A May, G Kowalski, D Callahan, C Bruce, N Alers, S Miller, J Erwich, E Wallace, D Walker, H Dickinson, R Snow
(2019), Vol. 25, pp. 495-505, Molecular Human Reproduction, England, C1
S Hamley, D Kloosterman, T Duthie, C Dalla Man, R Visentin, S Mason, T Ang, A Selathurai, G Kaur, M Morales-Scholz, K Howlett, G Kowalski, C Shaw, C Bruce
(2019), Vol. 62, pp. 2310-2324, Diabetologia, Berlin, Germany, C1
Treatment of type 2 diabetes with the designer cytokine IC7Fc
M Findeisen, T Allen, D Henstridge, H Kammoun, A Brandon, L Baggio, K Watt, M Pal, L Cron, E Estevez, C Yang, G Kowalski, L O’Reilly, C Egan, E Sun, L Thai, G Krippner, T Adams, R Lee, J Grötzinger, C Garbers, S Risis, M Kraakman, N Mellet, J Sligar, E Kimber, R Young, M Cowley, C Bruce, P Meikle, P Baldock, P Gregorevic, T Biden, G Cooney, D Keating, D Drucker, S Rose-John, M Febbraio
(2019), Vol. 574, pp. 63-68, Nature, England, C1
E Fletcher, J Salmon, S McNaughton, L Orellana, G Wadley, C Bruce, P Dempsey, K Lacy, D Dunstan
(2018), Vol. 21, pp. 280-285, Journal of science and medicine in sport, Amsterdam, The Netherlands, C1
D Morrison, G Kowalski, E Grespan, A Mari, C Bruce, G Wadley
(2018), Vol. 314, pp. E503-E511, American Journal of Physiology - Endocrinology and Metabolism, United States, C1
M Montgomery, R Mokhtar, J Bayliss, H Parkington, V Suturin, C Bruce, M Watt
(2018), Vol. 67, pp. 594-606, Diabetes, United States, C1
A Reichenbach, R Stark, M Mequinion, R Denis, J Goularte, R Clarke, S Lockie, M Lemus, G Kowalski, C Bruce, C Huang, R Schittenhelm, R Mynatt, B Oldfield, M Watt, S Luquet, Z Andrews
(2018), Vol. 22, pp. 1745-1759, Cell Reports, United States, C1
J Marshall, E Estevez, H Kammoun, E King, C Bruce, B Drew, H Qian, P Iliades, P Gregorevic, M Febbraio, D Henstridge
(2018), Vol. 20, pp. 1928-1936, Diabetes, Obesity and Metabolism, England, C1
Teddy Ang, Greg Kowalski, Clinton Bruce
(2018), Vol. 315, pp. E904-E911, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
N Turner, X Lim, H Toop, B Osborne, A Brandon, E Taylor, C Fiveash, H Govindaraju, J Teo, H McEwen, T Couttas, S Butler, A Das, G Kowalski, C Bruce, K Hoehn, T Fath, C Schmitz-Peiffer, G Cooney, M Montgomery, J Morris, A Don
(2018), Vol. 9, Nature Communications, England, C1
S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee
(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1
Creatine biosynthesis and transport by the term human placenta
S Ellery, P Della Gatta, C Bruce, G Kowalski, M Davies-Tuck, J Mockler, P Murthi, D Walker, R Snow, H Dickinson
(2017), Vol. 52, pp. 86-93, Placenta, Amsterdam, The Netherlands, C1
Does maternal-fetal transfer of creatine occur in pregnant sheep?
S Baharom, R De Matteo, S Ellery, P Della Gatta, C Bruce, G Kowalski, N Hale, H Dickinson, R Harding, D Walker, R Snow
(2017), Vol. 313, pp. E75-E83, American Journal of Physiology - Endocrinology and Metabolism, United States, C1
Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice
G Kowalski, M Kraakman, S Mason, A Murphy, C Bruce
(2017), Vol. 233, pp. 269-279, Journal of endocrinology, Bristol, Eng., C1
The effect of ingested glucose dose on the suppression of endogenous glucose production in humans
G Kowalski, S Moore, S Hamley, A Selathurai, C Bruce
(2017), Vol. 66, pp. 2400-2406, Diabetes, United States, C1
Increased liver AGEs induce hepatic injury mediated through an OST48 pathway
A Zhuang, F Yap, C Bruce, C Leung, M Plan, M Sullivan, C Herath, D McCarthy, K Sourris, P Kantharidis, M Coughlan, M Febbraio, M Hodson, M Watt, P Angus, B Schulz, J Forbes
(2017), Vol. 7, Scientific Reports, England, C1
J Wentworth, G Naselli, K Ngui, G Smyth, R Liu, P O'Brien, C Bruce, J Weir, M Cinel, P Meikle, L Harrison
(2016), Vol. 40, pp. 706-713, International Journal of Obesity, England, C1
G Lancaster, H Kammoun, M Kraakman, G Kowalski, C Bruce, M Febbraio
(2016), Vol. 7, Nature Communications, England, C1
G Kowalski, S Hamley, A Selathurai, J Kloehn, D De Souza, S O'Callaghan, B Nijagal, D Tull, M McConville, C Bruce
(2016), Vol. 6, Scientific Reports, England, C1
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Müller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschöp, M Watt, I Clarke, C Roth, K Grove, M Cowley
(2016), Vol. 5, pp. 807-822, Molecular Metabolism, Germany, C1
V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee
(2016), Vol. 16, pp. 2802-2810, Cell Reports, United States, C1
V Foletta, M Palmieri, J Kloehn, S Mason, S Previs, M McConville, O Sieber, C Bruce, G Kowalski
(2016), Vol. 6, Metabolites, Switzerland, C1
Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle
R Lee-Young, N Hoffman, K Murphy, D Henstridge, D Samocha-Bonet, A Siebel, P Iliades, B Zivanovic, Y Hong, T Colgan, M Kraakman, C Bruce, P Gregorevic, G McConell, G Lynch, G Drummond, B Kingwell, J Greenfield, M Febbraio
(2016), Vol. 5, pp. 1083-1091, Molecular Metabolism, Amsterdam, The Netherlands, C1
Greg Kowalski, Joachim Kloehn, Micah Burch, Ahrathy Selathurai, Steven Hamley, Stéphanie Bayol, Séverine Lamon, Matthew Watt, Robert Lee-Young, Malcolm McConville, C Bruce
(2015), Vol. 1851, pp. 210-219, Biochimica et Biophysica Acta (BBA)- molecular and cell biology of lipids, Amsterdam, Netherlands, C1
M Kraakman, H Kammoun, T Allen, V Deswaerte, D Henstridge, E Estevez, V Matthews, B Neill, D White, A Murphy, L Peijs, C Yang, S Risis, C Bruce, X-J Du, A Bobik, R Lee-Young, B Kingwell, A Vasanthakumar, W Shi, A Kallies, G Lancaster, S Rose-John, M Febbraio
(2015), Vol. 21, pp. 403-416, Cell metabolism, Amsterdam, The Netherlands, C1-1
ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle
R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt
(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1
G Kowalski, D De Souza, M Burch, S Hamley, J Kloehn, A Selathurai, D Tull, S O'Callaghan, M McConville, C Bruce
(2015), Vol. 462, pp. 27-32, Biochemical and Biophysical Research Communications, United States, C1
A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce
(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1
In vivo cardiac glucose metabolism in the high-fat fed mouse: comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach
G Kowalski, D De Souza, S Risis, M Burch, S Hamley, J Kloehn, A Selathurai, R Lee-Young, D Tull, S O'Callaghan, M McConville, C Bruce
(2015), Vol. 463, pp. 818-824, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1
P Sepulveda, S Lamon, A Hagg, R Thomson, C Winbanks, H Qian, C Bruce, A Russell, P Gregorevic
(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1
Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance
D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio
(2014), pp. 1-1, Diabetes, Alexandria, Virginia, C1
Fatty acid metabolism, energy expenditure and insulin resistance in muscle
N Turner, G Cooney, E Kraegen, C Bruce
(2014), Vol. 220, Journal of endocrinology, Bristol, England, C1-1
Growing healthy muscles to optimise metabolic health into adult life
S Bayol, C Bruce, G Wadley
(2014), Vol. 5, pp. 420-434, Journal of developmental origins of health and disease, Cambridge, United Kingdom, C1
G Kowalski, C Bruce
(2014), Vol. 307, pp. E859-E871, American journal of physiology-endocrinology and metabolism, Bethesda, MD, C1
PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
Rachael Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg Kowalski, Nancy Mokbel, Peter Meikle, Clinton Bruce, Matthew Watt
(2014), Vol. 3, pp. 652-663, Molecular metabolism, Amsterdam, Netherlands, C1-1
Plasma sphingosine-1-phosphate is elevated in obesity
G Kowalski, A Carey, A Selathurai, B Kingwell, C Bruce
(2013), Vol. 8, pp. 1-7, PloS one, San Francisco, Calif., C1-1
Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice
B Lindegaard, V Matthews, C Brandt, P Hojman, T Allen, E Estevez, M Watt, C Bruce, O Mortensen, S Syberg, C Rudnicka, J Abildgaard, H Pilegaard, J Hidalgo, S Ditlevsen, T Alsted, A Madsen, B Pedersen, M Febbraio
(2013), Vol. 62, pp. 3064-3074, Diabetes, Alexandria, Vir., C1-1
S Miura, Y Kai, M Tadaishi, Y Tokutake, K Sakamoto, C Bruce, M Febbraio, K Kita, S Chohnan, O Ezaki
(2013), Vol. 305, pp. E213-E229, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1
N Turner, G Kowalski, S Leslie, S Risis, C Yang, R Lee-Young, J Babb, P Meikle, G Lancaster, D Henstridge, P White, E Kraegen, A Marette, G Cooney, M Febbraio, C Bruce
(2013), Vol. 56, pp. 1638-1648, Diabetologia, Berlin, Germany, C1-1
C Bruce, S Risis, J Babb, C Yang, R Lee-Young, D Henstridge, M Febbraio
(2013), Vol. 154, pp. 65-76, Endocrinology, Washington, DC, C1-1
J Boon, A Hoy, R Stark, R Brown, R Meex, D Henstridge, S Schenk, P Meikle, J Horowitz, B Kingwell, C Bruce, M Watt
(2013), Vol. 62, pp. 401-410, Diabetes, Alexandria, Virginia, C1-1
C Bruce, S Risis, J Babb, C Yang, G Kowalski, A Selathurai, R Lee-Young, J Weir, K Yoshioka, Y Takuwa, P Meikle, S Pitson, M Febbraio
(2012), Vol. 61, pp. 3148-3155, Diabetes, Alexandria, Virginia, C1-1
D Henstridge, C Bruce, C Pang, G Lancaster, T Allen, E Estevez, T Gardner, J Weir, P Meikle, K Lam, A Xu, N Fujii, L Goodyear, M Febbraio
(2012), Vol. 55, pp. 2769-2778, Diabetologia, Berlin, Germany, C1-1
M Watt, A Barnett, C Bruce, S Schenk, J Horowitz, A Hoy
(2012), Vol. 55, pp. 2741-2746, Diabetologia, Berlin, Germany, C1-1
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes
Melissa Barber, Steve Risis, Christine Yang, Peter Meikle, Margaret Staples, Mark Febbraio, Clinton Bruce
(2012), Vol. 7, pp. e41456-e41456, PloS one, C1-1
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade
G Lancaster, B Skiba, C Yang, H Nicholls, K Langley, M Chan, C Bruce, G Rewcastle, P Shepherd, M Karin, M Febbraio
(2012), Vol. 442, pp. 723-732, Biochemical journal, London, England, C1-1
X Gao, Y Liu, D White, Y Su, B Drew, C Bruce, H Kiriazis, Q Xu, N Jennings, A Bobik, M Febbraio, B Kingwell, R Bucala, G Fingerle-Rowson, A Dart, E Morand, X Du
(2011), Vol. 50, pp. 991-999, Journal of molecular and cellular cardiology, Amsterdam, The Netherlands, C1-1
G Kowalski, H Nicholls, S Risis, N Watson, P Kanellakis, C Bruce, A Bobik, G Lancaster, M Febbraio
(2011), Vol. 54, pp. 888-899, Diabetologia, Berlin, Germany, C1-1
A Hoy, C Bruce, S Turpin, A Morris, M Febbraio, M Watt
(2011), Vol. 152, pp. 48-58, Endocrinology, Washington, DC, C1-1
The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet
Todd Mitchell, Todd Mitchell, Nigel Turner, Nigel Turner, Paul Else, Paul Else, Anthony Hulbert, Anthony Hulbert, John Hawley, John Hawley, Jong Lee, Jong Lee, Clinton Bruce, Clinton Bruce, Stephen Blanksby, Stephen Blanksby
(2010), Vol. 11, pp. 3954-3964, International journal of molecular sciences, C1-1
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
V Matthews, V Matthews, T Allen, T Allen, S Risis, S Risis, M Chan, M Chan, D Henstridge, D Henstridge, N Watson, N Watson, L Zaffino, L Zaffino, J Babb, J Babb, J Boon, J Boon, P Meikle, P Meikle, J Jowett, J Jowett, M Watt, M Watt, J Jansson, J Jansson, C Bruce, C Bruce, M Febbraio, M Febbraio
(2010), Vol. 53, pp. 2431-2441, Diabetologia, Berlin, Germany, C1-1
M Watt, D Van, L Castelli, C Bruce, A Hoy, E Kraegen, L Macaulay, B Kemp
(2010), Vol. 24, pp. 1308-1308, Molecular endocrinology, Washington, DC, C1-1
Reactive oxygen species enhance insulin sensitivity
Kim Loh, Kim Loh, Haiyang Deng, Haiyang Deng, Atsushi Fukushima, Atsushi Fukushima, Xiaochu Cai, Xiaochu Cai, Benoit Boivin, Benoit Boivin, Sandra Galic, Sandra Galic, Clinton Bruce, Clinton Bruce, Benjamin Shields, Benjamin Shields, Beata Skiba, Beata Skiba, Lisa Ooms, Lisa Ooms, others, others
(2009), Vol. 10, pp. 260-272, Cell metabolism, C1-1
V Matthews, V Matthews, M Aström, M Aström, M Chan, M Chan, C Bruce, C Bruce, K Krabbe, K Krabbe, O Prelovsek, O Prelovsek, T Akerström, T Akerström, C Yfanti, C Yfanti, C Broholm, C Broholm, O Mortensen, O Mortensen, M Penkowa, M Penkowa, P Hojman, P Hojman, A Zankari, A Zankari, M Watt, M Watt, H Bruunsgaard, H Bruunsgaard, B Pedersen, B Pedersen, M Febbraio, M Febbraio
(2009), Vol. 52, pp. 1409-1418, Diabetologia, Berlin, Germany, C1-1
A Hoy, A Hoy, A Brandon, A Brandon, N Turner, N Turner, M Watt, M Watt, C Bruce, C Bruce, G Cooney, G Cooney, E Kraegen, E Kraegen
(2009), Vol. 297, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1
AMP-activated protein kinase and muscle insulin resistance
E Kraegen, E Kraegen, C Bruce, C Bruce, B Hegarty, B Hegarty, J Ye, J Ye, N Turner, N Turner, G Cooney, G Cooney
(2009), Vol. 14, pp. 4658-4672, Frontiers in bioscience, Irvine, California, C1-1
C Bruce, C Bruce, A Hoy, A Hoy, N Turner, N Turner, M Watt, M Watt, T Allen, T Allen, K Carpenter, K Carpenter, G Cooney, G Cooney, M Febbraio, M Febbraio, E Kraegen, E Kraegen
(2009), Vol. 58, pp. 550-558, Diabetes, Alexandria, Virginia, C1-1
S Miura, S Miura, Y Kai, Y Kai, Y Kamei, Y Kamei, C Bruce, C Bruce, N Kubota, N Kubota, M Febbraio, M Febbraio, T Kadowaki, T Kadowaki, O Ezaki, O Ezaki
(2009), Vol. 296, American journal of physiology : endocrinology and metabolism, Bethesda, Maryland, C1-1
A Holmes, A Holmes, J Mesa, J Mesa, B Neill, B Neill, J Chung, J Chung, A Carey, A Carey, G Steinberg, G Steinberg, B Kemp, B Kemp, R Southgate, R Southgate, G Lancaster, G Lancaster, C Bruce, C Bruce, M Watt, M Watt, M Febbraio, M Febbraio
(2008), Vol. 198, pp. 367-374, Journal of endocrinology, Bristol, England, C1-1
M Watt, M Watt, B Van Denderen, B Van Denderen, L Castelli, L Castelli, C Bruce, C Bruce, A Hoy, A Hoy, E Kraegen, E Kraegen, L Macaulay, L Macaulay, B Kemp, B Kemp
(2008), Vol. 22, pp. 1200-1212, Molecular endocrinology, Washington, DC, C1-1
HSP72 protects against obesity-induced insulin resistance
J Chung, J Chung, A Nguyen, A Nguyen, D Henstridge, D Henstridge, A Holmes, A Holmes, M Chan, M Chan, J Mesa, J Mesa, G Lancaster, G Lancaster, R Southgate, R Southgate, C Bruce, C Bruce, S Duffy, S Duffy, I Horvath, I Horvath, R Mestril, R Mestril, M Watt, M Watt, P Hooper, P Hooper, B Kingwell, B Kingwell, L Vigh, L Vigh, A Hevener, A Hevener, M Febbraio, M Febbraio
(2008), Vol. 105, pp. 1739-1744, Proceedings of the National Academy of Sciences of the United States of America, Washington, DC, C1-1
N Turner, N Turner, C Bruce, C Bruce, S Beale, S Beale, K Hoehn, K Hoehn, T So, T So, M Rolph, M Rolph, G Cooney, G Cooney
(2007), Vol. 56, pp. 2085-2092, Diabetes, Alexandria, Va, C1-1
A Hoy, A Hoy, C Bruce, C Bruce, A Cederberg, A Cederberg, N Turner, N Turner, D James, D James, G Cooney, G Cooney, E Kraegen, E Kraegen
(2007), Vol. 293, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
C Bruce, C Bruce, C Brolin, C Brolin, N Turner, N Turner, M Cleasby, M Cleasby, R van der Leij Feike, R van der Leij Feike, G Cooney, G Cooney, E Kraegen, E Kraegen
(2007), Vol. 292, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
A Carey, A Carey, E Petersen, E Petersen, C Bruce, C Bruce, R Southgate, R Southgate, H Pilegaard, H Pilegaard, J Hawley, J Hawley, B Pedersen, B Pedersen, M Febbraio, M Febbraio
(2006), Vol. 49, pp. 1000-1007, Diabetologia, Heidelberg, Germany, C1-1
C Collier, C Collier, C Bruce, C Bruce, A Smith, A Smith, G Lopaschuk, G Lopaschuk, D Dyck, D Dyck
(2006), Vol. 291, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
C Bruce, C Bruce, A Thrush, A Thrush, V Mertz, V Mertz, V Bezaire, V Bezaire, A Chabowski, A Chabowski, G Heigenhauser, G Heigenhauser, D Dyck, D Dyck
(2006), Vol. 291, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
V Bezaire, V Bezaire, C Bruce, C Bruce, G Heigenhauser, G Heigenhauser, N Tandon, N Tandon, J Glatz, J Glatz, J Luiken, J Luiken, A Bonen, A Bonen, L Spriet, L Spriet
(2006), Vol. 290, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
R Southgate, C Bruce, A Carey, G Steinberg, K Walder, R Monks, M Watt, J Hawley, M Birnbaum, M Febbraio
(2005), Vol. 19, pp. 2072-2074, The FASEB journal : official publication of the Federation of American Societies for experimental biology, Bethesda, Md., C1-1
C Bruce, C Bruce, V Mertz, V Mertz, G Heigenhauser, G Heigenhauser, D Dyck, D Dyck
(2005), Vol. 54, pp. 3154-3160, Diabetes, Alexandria, Va, C1-1
A Smith, A Smith, C Bruce, C Bruce, D Dyck, D Dyck
(2005), Vol. 565, pp. 537-546, Journal of physiology, West Sussex, England, C1-1
A Smith, A Smith, C Bruce, C Bruce, D Dyck, D Dyck
(2005), Vol. 565, pp. 547-553, Journal of physiology, West Sussex, England, C1-1
G Wadley, C Bruce, N Konstantopoulos, J Macauley, K Howlett, J Hawley, D Cameron-Smith
(2004), Vol. 47, pp. 412-419, Diabetologia, Berlin, Germany, C1
Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity
Melissa Arkinstall, Clinton Bruce, Sally Clark, Caroline Rickards, Louise Burke, John Hawley
(2004), Vol. 97, pp. 2275-2283, Journal of applied physiology, C1
Exercise alters the profile of phospholipid molecular species in rat skeletal muscle
T Mitchell, T Mitchell, N Turner, N Turner, A Hulbert, A Hulbert, P Else, P Else, J Hawley, J Hawley, J Lee, J Lee, C Bruce, C Bruce, S Blanksby, S Blanksby
(2004), Vol. 97, pp. 1823-1829, Journal of applied physiology, Bethesda, Md., C1-1
Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats
C Bruce, C Bruce, J Lee, J Lee, B Kiens, B Kiens, J Hawley, J Hawley
(2004), Vol. 12, pp. 1158-1165, Obesity research, Hoboken, N.J., C1-1
C Bruce, C Bruce, D Dyck, D Dyck
(2004), Vol. 287, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
Improvements in insulin resistance with exercise training: a lipocentric approach
C Bruce, C Bruce, J Hawley, J Hawley
(2004), Vol. 36, pp. 1196-1201, Medicine and science in sports and exercise, Philadelphia, PA, C1-1
A Carey, A Carey, C Bruce, C Bruce, M Sacchetti, M Sacchetti, M Anderson, M Anderson, D Olsen, D Olsen, B Saltin, B Saltin, J Hawley, J Hawley, M Febbraio, M Febbraio
(2004), Vol. 47, pp. 1029-1037, Diabetologia, Heidelberg, Germany, C1-1
Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle
N Turner, N Turner, J Lee, J Lee, C Bruce, C Bruce, T Mitchell, T Mitchell, P Else, P Else, A Hulbert, A Hulbert, J Hawley, J Hawley
(2004), Vol. 96, pp. 974-980, Journal of applied physiology, Bethesda, Md., C1-1
C Bruce, C Bruce, A Kriketos, A Kriketos, G Cooney, G Cooney, J Hawley, J Hawley
(2004), Vol. 47, pp. 23-30, Diabetologia, Heidelberg, Germany, C1-1
Dietary regulation of fat oxidative gene expression in different skeletal musle fiber types
A McAinch, J Lee, C Bruce, R Tunstall, J Hawley, D Cameron-Smith
(2003), Vol. 11, pp. 1471-1479, Obesity research, Baton Rouge, La., C1
Muscle oxidative capacity is a better predictor of insulin sensitivity than lipid status
C Bruce, C Bruce, M Anderson, M Anderson, A Carey, A Carey, D Newman, D Newman, A Bonen, A Bonen, A Kriketos, A Kriketos, G Cooney, G Cooney, J Hawley, J Hawley
(2003), Vol. 88, pp. 5444-5451, Journal of clinical endocrinology and metabolism, Washington, DC, C1-1
C Bruce, C Bruce, A Carey, A Carey, J Hawley, J Hawley, M Febbraio, M Febbraio
(2003), Vol. 52, pp. 2338-2345, Diabetes, Alexandria, Va, C1-1
J Lee, C Bruce, R Tunstall, D Cameron-Smith, H Hugel, J Hawley
(2002), Vol. 175, pp. 37-44, Acta physiologica Scandinavica, Oxford, England, C1
Effect of different protocols of caffeine intake on metabolism and endurance performance
G Cox, G Cox, B Desbrow, B Desbrow, P Montgomery, P Montgomery, M Anderson, M Anderson, C Bruce, C Bruce, T Macrides, T Macrides, D Martin, D Martin, A Moquin, A Moquin, A Roberts, A Roberts, J Hawley, J Hawley, L Burke, L Burke
(2002), Vol. 93, pp. 990-999, Journal of applied physiology, Bethesda, Md., C1-1
J Lee, J Lee, C Bruce, C Bruce, B Spurrell, B Spurrell, J Hawley, J Hawley
(2002), Vol. 29, pp. 655-660, Clinical and experimental pharmacology and physiology, Richmond, VIC, C1-1
Effect of carbohydrate ingestion on metabolism during running and cycling
M Arkinstall, C Bruce, V Nikolopoulos, A Garnham, J Hawley
(2001), Vol. 91, pp. 2125-2134, Journal of applied physiology, Bethesada, Md., C1
Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats
C Bruce, C Bruce, J Lee, J Lee, J Hawley, J Hawley
(2001), Vol. 91, pp. 1512-1519, Journal of applied physiology, Bethesda, Md., C1-1
Interaction of diet and training on endurance performance in rats
J Lee, J Lee, C Bruce, C Bruce, L Spriet, L Spriet, J Hawley, J Hawley
(2001), Vol. 86, pp. 499-508, Experimental physiology, West Sussex, England, C1-1
Improved 2000-meter rowing performance in competitive oarswomen after caffeine ingestion
M Anderson, M Anderson, C Bruce, C Bruce, S Fraser, S Fraser, N Stepto, N Stepto, R Klein, R Klein, W Hopkins, W Hopkins, J Hawley, J Hawley
(2000), Vol. 10, pp. 464-475, International journal of sport nutrition and exercise metabolism, Champaign, IL, C1-1
Enhancement of 2000-m rowing performance after caffeine ingestion
C Bruce, C Bruce, M Anderson, M Anderson, S Fraser, S Fraser, N Stepto, N Stepto, R Klein, R Klein, W Hopkins, W Hopkins, J Hawley, J Hawley
(2000), Vol. 32, pp. 1958-1963, Medicine and science in sports and exercise, Philadelphia, PA, C1-1
Funded Projects at Deakin
Australian Competitive Grants
Activation of HSP72 in skeletal muscle as a therapeutic target for obesity
Prof Mark Febbraio, Prof Clinton Bruce, Prof Sean Mcgee, Prof Mark Hargreaves
NHMRC Project Grant
- 2013: $20,000
- 2012: $20,000
Sphingosine kinase: a target for obesity-induced insulin resistance
Prof Clinton Bruce, Dr Robert Lee-Young
NHMRC Project Grant
- 2014: $251,815
Understanding the mechanisms of diet-induced defects in hepatic glucose metabolism.
Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2014: $60,000
Targeting hepatic energy expenditure to improve glycaemic control
Dr Greg Kowalski, Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2015: $30,000
- 2014: $30,000
Does mitochondrial dysfunction impair muscle glucose metabolism?
Prof Clinton Bruce, Dr Greg Kowalski, Dr Gunveen Kaur
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2015: $60,000
Liver-type pyruvate kinase: a novel anti-hyperglycemic target
Dr Greg Kowalski, Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2016: $59,950
The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes
Prof Sean Mcgee, Prof Clinton Bruce, Prof Forest White, Prof Ken Walder
NHMRC Project Grant
- 2020: $10,462
- 2019: $187,097
- 2018: $181,879
- 2017: $169,227
Defining a novel pathway in the regulation of skeletal muscle mass
Prof Clinton Bruce
ARC Fellowships - Future Fellowships
- 2020: $108,821
- 2019: $213,793
- 2018: $209,631
- 2017: $308,533
The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy
Prof Sean Mcgee, Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2017: $59,962
Mechanisms of insulin resistance in humans
Prof Clinton Bruce, Dr Greg Kowalski
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2019: $60,000
Metabolic tug-of-war: deciphering the role of glucagon and insulin under physiologically relevant conditions in humans
Dr Greg Kowalski, Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2019: $59,900
Aminogenic insulin-glucagon secretion and action in human insulin resistance
Dr Greg Kowalski, Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2020: $60,000
Using 'omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS
Prof Ken Walder, Prof Michael Berk, Dr Chiara Bortolasci, Prof Sean Mcgee, Prof Clinton Bruce, Dr Wolf Marx
NHMRC Targeted Call for Research into Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Grant Opportunity
- 2023: $211,170
- 2022: $164,314
- 2021: $152,361
- 2020: $25,320
Fasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance
Dr Chris Shaw, Prof Clinton Bruce, Dr Kirsten Howlett, Prof Sean Mcgee, Dr Greg Kowalski
Diabetes Australia Research Program Grant
- 2021: $59,895
A novel ¿liquid biopsy¿ approach to study in vivo ¿-cell insulin synthesis in humans
Dr Greg Kowalski, Prof Clinton Bruce, Dr Chris Shaw
Diabetes Australia Research Program Grant
- 2022: $69,340
Deciphering the mechanisms of prostprandial glucose disposal
Dr Chris Shaw, Prof Clinton Bruce, Dr Greg Kowalski, Dr Kirsten Howlett
Diabetes Australia Research Program Grant
- 2022: $69,911
Industry and Other Funding
Determination of 6,6-2H glucose enrichment in plasma
Prof Clinton Bruce, Dr Greg Kowalski
Baker IDI Heart and Diabetes Institute Holdings Limited
- 2015: $1,920
Measurement of plasma free fatty acids
Prof Clinton Bruce, Dr Greg Kowalski
CSL Limited
- 2016: $2,200
Can dietary supplementation with Krill-Oil improve ME/CFS symptoms?
Dr Lee Hamilton, Prof Ken Walder, Dr Giselle Allsopp, Dr Chris Shaw, Dr Greg Kowalski, Prof Clinton Bruce, Dr Craig Wright, Dr Rhiannon Snipe
Equity Trustees - The Mason Foundation National Medical Program
- 2023: $90,000
- 2022: $100,000
Investigating the role of neurturin as a therapeutic strategy to delay ALS disease progression
Prof Aaron Russell, Prof Jorge Ruas, Prof Clinton Bruce, Dr Paul Della Gatta, Dr Angus Lindsay, Dr Angus Lindsay
Motor Neurone Disease Australia Inc (MND Aust)
- 2023: $50,000
Other Funding Sources
Determination of 6,6-2H glucose enrichment in plasma
Prof Clinton Bruce, Dr Greg Kowalski
Monash University
- 2017: $776
- 2016: $1,520
- 2015: $1,710
Determination of lipogenesis in liver cancer
Prof Clinton Bruce, Dr Greg Kowalski
University of New South Wales (CAT8)
- 2016: $4,000
Supervisions
Wei (Teddy) Ang
Thesis entitled: Understanding the Physiologic Regulation of Endogenous Glucose Production
Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences
Steven Douglas Hamley
Thesis entitled: Understanding the Mechanisms of Hyperinsulinemia
Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences
Dale John Morrison
Thesis entitled: Quantification of postprandial glucose flux following endurance exercise training and overfeeding by the triple tracer technique
Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences