Biography
My research spans the metabolic biochemistry, integrative physiology, endocrinology and analytical chemistry fields. Specifically, I am interested in insulin and glucagon action as well as understanding how pathways of central carbon metabolism (glucose, lipids, amino acids) are coordinated across different organ systems (liver, muscle, pancreas, adipose) in vivo. A particular interest is in the organ specific evolution of insulin resistance and hyperinsulinaemia along with the role they play in disease development, including diabetes and cardiovascular disease. I am also interested in skeletal muscle phospholipid metabolism and how it relates to mitochondrial structure and function. I utilise both human and rodent in vivo experimentation, and am specialised in the use of stable isotope metabolic tracer methodology and quantitative metabolomics. I also manage the biological gas chromatography-mass spectrometry platform within the School of Exercise and Nutrition Sciences.
Read more on Greg's profilePublications
María Morales-Scholz, Courtney Swinton, Robyn Murphy, Greg Kowalski, Clinton Bruce, Kirsten Howlett, Christopher Shaw
(2021), Vol. 534, pp. 533-539, Biochemical and Biophysical Research Communications, Amsterdam, The Netherlands, C1
The effects of early-onset pre-eclampsia on placental creatine metabolism in the third trimester
S Ellery, P Murthi, P Gatta, A May, M Davies-Tuck, G Kowalski, D Callahan, C Bruce, E Wallace, D Walker, H Dickinson, R Snow
(2020), Vol. 21, pp. 1-14, International journal of molecular sciences, Basel, Switzerland, C1
H Beyene, S Hamley, C Giles, K Huynh, A Smith, M Cinel, N Mellet, M Morales-Scholz, D Kloosterman, K Howlett, G Kowalski, C Shaw, D Magliano, C Bruce, P Meikle
(2020), Vol. 105, pp. e1041-e1055, The Journal of clinical endocrinology and metabolism, Oxford, Eng., C1
T Allerton, G Kowalski, H Hang, J Stephens
(2020), Vol. 319, pp. E2-E10, American Journal of Physiology - Endocrinology and Metabolism, Bethesda, Md., C1
Sheik Elahee Doomun, Shuai Nie, Stella Loke, Greg Kowalski, Peter Beech, Damien Callahan
(2020), pp. 1-10, Journal of the American Society for Mass Spectrometry, Washington, D.C., C1
N Poddar, S Elahee Doomun, D Callahan, Greg Kowalski, G Martin
(2020), Biotechnology and Bioengineering, Hoboken, N.J., C1
J Mikovic, C Brightwell, A Lindsay, Y Wen, G Kowalski, A Russell, C Fry, S Lamon
(2020), Vol. 319, pp. E1008-E1018, American Journal of Physiology - Endocrinology and Metabolism, Bethesda, Md., C1
K De Jong, L Hall, M Renton, T Connor, S Martin, G Kowalski, C Shaw, C Bruce, K Howlett, S McGee
(2020), Vol. 42, pp. 1-11, Molecular metabolism, Amsterdam, The Netherlands, C1
Timothy Allerton, Greg Kowalski, James Stampley, Brian Irving, John Lighton, Z Floyd, Jacqueline Stephens
(2020), pp. 1-52, Medicine & Science in Sports & Exercise, Philadelphia, Pa., C1
Postprandial aminogenic insulin and glucagon secretion can stimulate glucose flux in humans
Teddy Ang, Clinton Bruce, Greg Kowalski
(2019), Vol. 68, pp. 939-946, Diabetes, Arlington, Va., C1
Mary Berry, Melissa Schlegel, Greg Kowalski, Clinton Bruce, Damien Callahan, Miranda Davies-Tuck, Hayley Dickinson, Angus Goodson, Angie Slocombe, Rod Snow, David Walker, Stacey Ellery
(2019), Vol. 10, pp. 1-8, Frontiers in physiology, Lausanne, Switzerland, C1
Dale Morrison, Greg Kowalski, Clinton Bruce, Glenn Wadley
(2019), Vol. 316, pp. E1061-E1070, American journal of physiology. Endocrinology and metabolism, Bethesda, Md., C1
Lewin Small, Amanda Brandon, Benjamin Parker, Vinita Deshpande, Azrah Samsudeen, Greg Kowalski, Jane Reznick, Donna Wilks, Elaine Preston, Clinton Bruce, David James, Nigel Turner, Gregory Cooney
(2019), Vol. 25, pp. 107-118, Molecular metabolism, Amsterdam, The Netherlands, C1
A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce
(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1
Placental creatine metabolism in cases of placental insufficiency and reduced fetal growth
Stacey Ellery, Padma Murthi, Miranda Davies-Tuck, Paul Della Gatta, Anthony May, Greg Kowalski, Damien Callahan, Clinton Bruce, Nicole Alers, Suzanne Miller, Jan Erwich, Euan Wallace, David Walker, Hayley Dickinson, Rod Snow
(2019), Vol. 25, pp. 495-505, Molecular human reproduction, Oxford, Eng., C1
S Hamley, D Kloosterman, T Duthie, C Dalla Man, R Visentin, S Mason, T Ang, A Selathurai, G Kaur, M Morales-Scholz, K Howlett, G Kowalski, C Shaw, C Bruce
(2019), Vol. 62, pp. 2310-2324, Diabetologia, Berlin, Germany, C1
Treatment of type 2 diabetes with the designer cytokine IC7Fc
M Findeisen, T Allen, D Henstridge, H Kammoun, A Brandon, L Baggio, K Watt, M Pal, L Cron, E Estevez, C Yang, G Kowalski, L O’Reilly, C Egan, E Sun, L Thai, G Krippner, T Adams, R Lee, J Grötzinger, C Garbers, S Risis, M Kraakman, N Mellet, J Sligar, E Kimber, R Young, M Cowley, C Bruce, P Meikle, P Baldock, P Gregorevic, T Biden, G Cooney, D Keating, D Drucker, S Rose-John, M Febbraio
(2019), Vol. 574, pp. 63-68, Nature, London, Eng., C1
D Morrison, G Kowalski, E Grespan, A Mari, C Bruce, G Wadley
(2018), Vol. 314, pp. E503-E511, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1
A Reichenbach, R Stark, M Mequinion, R Denis, J Goularte, R Clarke, S Lockie, M Lemus, G Kowalski, C Bruce, C Huang, R Schittenhelm, R Mynatt, B Oldfield, M Watt, S Luquet, Z Andrews
(2018), Vol. 22, pp. 1745-1759, Cell reports, Amsterdam, The Netherlands, C1
Teddy Ang, Greg Kowalski, Clinton Bruce
(2018), Vol. 315, pp. E904-E911, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
Nigel Turner, Xin Lim, Hamish Toop, Brenna Osborne, Amanda Brandon, Elysha Taylor, Corrine Fiveash, Hemna Govindaraju, Jonathan Teo, Holly McEwen, Timothy Couttas, Stephen Butler, Abhirup Das, Greg Kowalski, Clinton Bruce, Kyle Hoehn, Thomas Fath, Carsten Schmitz-Peiffer, Gregory Cooney, Magdalene Montgomery, Jonathan Morris, Anthony Don
(2018), Vol. 9, Nature communications, London, Eng., C1
S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee
(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1
Creatine biosynthesis and transport by the term human placenta
S Ellery, P Della Gatta, C Bruce, G Kowalski, M Davies-Tuck, J Mockler, P Murthi, D Walker, R Snow, H Dickinson
(2017), Vol. 52, pp. 86-93, Placenta, Amsterdam, The Netherlands, C1
Does maternal-fetal transfer of creatine occur in pregnant sheep?
S Baharom, R De Matteo, S Ellery, P Della Gatta, C Bruce, G Kowalski, N Hale, H Dickinson, R Harding, D Walker, R Snow
(2017), Vol. 313, pp. E75-E83, American journal of physiology, endocrinology and metabolism, Bethesda, Md., C1
Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice
G Kowalski, M Kraakman, S Mason, A Murphy, C Bruce
(2017), Vol. 233, pp. 269-279, Journal of endocrinology, Bristol, Eng., C1
The effect of ingested glucose dose on the suppression of endogenous glucose production in humans
G Kowalski, S Moore, S Hamley, A Selathurai, C Bruce
(2017), Vol. 66, pp. 2400-2406, Diabetes, Arlington County, Va., C1
G Lancaster, H Kammoun, M Kraakman, G Kowalski, C Bruce, M Febbraio
(2016), Vol. 7, pp. 1-10, Nature communications, London, Eng., C1
M Wallace, P Della Gatta, B Mir, G Kowalski, J Kloehn, M McConville, A Russell, S Lamon
(2016), Vol. 7, pp. 1-13, Frontiers in physiology, Lausanne, Switzerland, C1
G Kowalski, S Hamley, A Selathurai, J Kloehn, D De Souza, S O’Callaghan, B Nijagal, D Tull, M McConville, C Bruce
(2016), Vol. 6, pp. 1-10, Scientific reports, London, Eng., C1
Strategies for extending metabolomics studies with stable isotope labelling and fluxomics
A Srivastava, G Kowalski, D Callahan, P Meikle, D Creek
(2016), Vol. 6, pp. 1-13, Metabolites, Basel, Switzerland, C1
V Foletta, M Palmieri, J Kloehn, S Mason, S Previs, M McConville, O Sieber, C Bruce, G Kowalski
(2016), Vol. 6, pp. 1-19, Metabolites, Basel, Switzerland, C1
Greg Kowalski, Joachim Kloehn, Micah Burch, Ahrathy Selathurai, Steven Hamley, Stéphanie Bayol, Séverine Lamon, Matthew Watt, Robert Lee-Young, Malcolm McConville, C Bruce
(2015), Vol. 1851, pp. 210-219, Biochimica et Biophysica Acta (BBA)- molecular and cell biology of lipids, Amsterdam, Netherlands, C1
G Kowalski, D De Souza, M Burch, S Hamley, J Kloehn, A Selathurai, D Tull, S O'Callaghan, M McConville, C Bruce
(2015), Vol. 462, pp. 27-32, Biochemical and Biophysical Research Communications, C1
A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce
(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1
In vivo cardiac glucose metabolism in the high-fat fed mouse: comparison of euglycemic-hyperinsulinemic clamp derived measures of glucose uptake with a dynamic metabolomic flux profiling approach
G Kowalski, D De Souza, S Risis, M Burch, S Hamley, J Kloehn, A Selathurai, R Lee-Young, D Tull, S O'Callaghan, M McConville, C Bruce
(2015), Vol. 463, pp. 818-824, Biochemical and biophysical research communications, Amsterdam, The Netherlands, C1
G Kowalski, C Bruce
(2014), Vol. 307, pp. E859-E871, American journal of physiology-endocrinology and metabolism, Bethesda, MD, C1
PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
Rachael Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg Kowalski, Nancy Mokbel, Peter Meikle, Clinton Bruce, Matthew Watt
(2014), Vol. 3, pp. 652-663, Molecular metabolism, Amsterdam, Netherlands, C1-1
Plasma sphingosine-1-phosphate is elevated in obesity
G Kowalski, A Carey, A Selathurai, B Kingwell, C Bruce
(2013), Vol. 8, pp. 1-7, PloS one, San Francisco, Calif., C1-1
N Turner, G Kowalski, S Leslie, S Risis, C Yang, R Lee-Young, J Babb, P Meikle, G Lancaster, D Henstridge, P White, E Kraegen, A Marette, G Cooney, M Febbraio, C Bruce
(2013), Vol. 56, pp. 1638-1648, Diabetologia, C1-1
C Bruce, S Risis, J Babb, C Yang, G Kowalski, A Selathurai, R Lee-Young, J Weir, K Yoshioka, Y Takuwa, P Meikle, S Pitson, M Febbraio
(2012), Vol. 61, pp. 3148-3155, Diabetes, C1-1
G Lancaster, G Kowalski, E Estevez, M Kraakman, G Grigoriadis, M Febbraio, S Gerondakis, A Banerjee
(2012), Vol. 7, PLoS ONE, C1-1
G Kowalski, H Nicholls, S Risis, N Watson, P Kanellakis, C Bruce, A Bobik, G Lancaster, M Febbraio
(2011), Vol. 54, pp. 888-899, Diabetologia, C1-1
H Nicholls, G Kowalski, D Kennedy, S Risis, L Zaffino, N Watson, P Kanellakis, M Watt, A Bobik, A Bonen, M Febbraio, G Lancaster, M Febbraio
(2011), Vol. 60, pp. 1100-1110, Diabetes, C1-1
Y Xu, P Schnorrer, A Proietto, G Kowalski, M Febbraio, H Acha-Orbea, R Dickins, J Villadangos
(2011), Vol. 186, pp. 3666-3673, Journal of Immunology, C1-1
Funded Projects at Deakin
Australian Competitive Grants
Targeting hepatic energy expenditure to improve glycaemic control
Dr Greg Kowalski, A/Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2015: $30,000
- 2014: $30,000
Does mitochondrial dysfunction impair muscle glucose metabolism?
A/Prof Clinton Bruce, Dr Greg Kowalski, Dr Gunveen Kaur
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2015: $60,000
Liver-type pyruvate kinase: a novel anti-hyperglycemic target
Dr Greg Kowalski, A/Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2016: $59,950
Phosphatidylserine: a regulator of muscle and mitochondrial biology?
Dr Greg Kowalski
ARC DECRA - Discovery Early Career Researcher Award
- 2020: $130,507
- 2019: $127,465
- 2018: $125,192
Mechanisms of insulin resistance in humans
A/Prof Clinton Bruce, Dr Greg Kowalski
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2019: $60,000
Metabolic tug-of-war: deciphering the role of glucagon and insulin under physiologically relevant conditions in humans
Dr Greg Kowalski, A/Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2019: $59,900
Aminogenic insulin-glucagon secretion and action in human insulin resistance
Dr Greg Kowalski, A/Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2020: $60,000
Fasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance
Dr Chris Shaw, A/Prof Clinton Bruce, Dr Kirsten Howlett, Prof Sean Mcgee, Dr Greg Kowalski
Diabetes Australia Research Program Grant
- 2021: $29,947
Industry and Other Funding
Determination of 6,6-2H glucose enrichment in plasma
A/Prof Clinton Bruce, Dr Greg Kowalski
- 2015: $1,920
Measurement of plasma free fatty acids
A/Prof Clinton Bruce, Dr Greg Kowalski
- 2016: $2,200
Other Funding Sources
Determination of 6,6-2H glucose enrichment in plasma
A/Prof Clinton Bruce, Dr Greg Kowalski
- 2017: $776
- 2016: $1,520
- 2015: $1,710
Determination of lipogenesis in liver cancer
A/Prof Clinton Bruce, Dr Greg Kowalski
- 2016: $4,000
Supervisions
Dale John Morrison
Thesis entitled: Quantification of postprandial glucose flux following endurance exercise training and overfeeding by the triple tracer technique
Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences