Research interests
Research in the Stambas laboratory is primarily focused on understanding immune responses following virus infection and vaccination. The main scientific aim is to carefully dissect immune responses following virus infection and vaccination to determine relevant immune correlates of protection in order to drive innovative strategies for future vaccine or therapeutic development. Prof. Stambas has made a significant contribution to his field as evidenced by his publication history and his invitations to organise and present at local, national and international conferences.
Affiliations
Honorary Senior Fellow, Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia, 3010. (Nov 2009-present)
Teaching interests
Prof. Stambas undertsands the importance of training the next generation of scientists, science educators or health professionals and as such teaches immunology to undergraduate students in the Bachelor of Biomedical Science degree at Deakin University.
Prof. Stambas served as Course Director for the School of Medicine Honours Program between 2011-2019 and in 2020 was appointed HDR coordinator in the school. He trains honours, M Phil and PhD students in his laboratory.
Units taught
HMM204 and HMO 303
Knowledge areas
immunology, virology, adaptive and innate immunity, influenza virus and T cells
Professional activities
Australasian Society for Immunology (ASI); 1996-present
American Association of Immunologists (AAI); 2003-present
Australasian Society for Immunology Treasurer and Executive member; 2013-2015
Member of the Safeguarding Australia Expert Working Group, developing a Strategic Roadmap for Australian Research Infrastructure for the Department of Innovation, Industry, Science and Research, Australian Government; 2011
Immunology Group of Victoria (IgV) committee, local branch of the Australasian Society for Immunology (ASI); 2008-2012
Plos One, Academic Editor; 2012-present
Awards
Prof. Stambas has been awarded numerous competitive research and travel grants from local, national and international funding agencies including the NHMRC, ARC and AAI. Prof. Stambas has previously received a C.R. Roper Fellowship to undertake post-doctoral training at the University of Melbourne and was awarded a Gordon Ada Senior Travel Award from the Australian and New Zealand Society for Immunology.
Publications
R Tripp, J Stambas
(2021), Vol. 13, Viruses, Switzerland, C1
J Pedrina, J Stambas
(2021), Vol. 8, Frontiers in Molecular Biosciences, Switzerland, C1
Extracellular Matrix Enzymes and Immune Cell Biology
M McMahon, S Ye, J Pedrina, D Dlugolenski, J Stambas
(2021), Vol. 8, Frontiers in Molecular Biosciences, Switzerland, C1
H Muflihah, M Flórido, L Lin, Y Xia, J Triccas, J Stambas, W Britton
(2021), Vol. 16, PLoS ONE, United States, C1
Innate and adaptive immune responses in respiratory virus infection: implications for the clinic
J Stambas, C Lu, R Tripp
(2020), Vol. 14, pp. 1141-1147, Expert review of respiratory medicine, Abingdon, Eng., C1
A Ashhurst, M Flórido, L Lin, D Quan, E Armitage, S Stifter, J Stambas, W Britton
(2019), Vol. 10, Frontiers in Immunology, Switzerland, C1
D Zanker, S Oveissi, D Tscharke, M Duan, S Wan, X Zhang, K Xiao, N Mifsud, J Gibbs, L Izzard, D Dlugolenski, P Faou, K Laurie, N Vigneron, I Barr, J Stambas, B Van Den Eynde, J Bennink, J Yewdell, W Chen
(2019), Vol. 202, pp. 3370-3380, Journal of Immunology, United States, C1
Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo
S Stifter, N Bhattacharyya, A Sawyer, T Cootes, J Stambas, S Doyle, L Feigenbaum, W Paul, W Britton, A Sher, C Feng
(2019), Vol. 29, pp. 3539-3550.e4, Cell Reports, United States, C1
H Muflihah, M Flórido, L Lin, Y Xia, J Triccas, J Stambas, W Britton
(2018), Vol. 36, pp. 2462-2470, Vaccine, Netherlands, C1
J Luczo, M Tachedjian, J Harper, J Payne, J Butler, S Sapats, S Lowther, W Michalski, J Stambas, J Bingham
(2018), Vol. 8, Scientific Reports, England, C1
M Flórido, H Muflihah, L Lin, Y Xia, F Sierro, M Palendira, C Feng, P Bertolino, J Stambas, J Triccas, W Britton
(2018), Vol. 11, pp. 1743-1752, Mucosal Immunology, United States, C1
S Ye, C Cowled, C Yap, J Stambas
(2018), Vol. 8, Scientific Reports, England, C1
Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome
L Izzard, D Dlugolenski, Y Xia, M McMahon, D Middleton, R Tripp, J Stambas
(2017), Vol. 235, pp. 115-120, Virus Research, Netherlands, C1
H-X Tan, B Gilbertson, S Jegaskanda, S Alcantara, T Amarasena, J Stambas, J McAuley, S Kent, R De Rose
(2016), Vol. 34, pp. 1172-1179, Vaccine, Amsterdam, The Netherlands, C1
ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity
M McMahon, S Ye, L Izzard, D Dlugolenski, R Tripp, A Bean, D McCulloch, J Stambas
(2016), Vol. 14, PLoS Biology, United States, C1
S Ye, S Lowther, J Stambas
(2015), Vol. 89, pp. 2672-2683, Journal of Virology, United States, C1
M Flórido, R Pillay, C Gillis, Y Xia, S Turner, J Triccas, J Stambas, W Britton
(2015), Vol. 45, pp. 780-793, European journal of immunology, Weinheim, Germany, C1
J Luczo, J Stambas, P Durr, W Michalski, J Bingham
(2015), Vol. 25, pp. 406-430, Reviews in medical virology, London, Eng., C1
Influenza reverse genetics: dissecting immunity and pathogenesis
S Ye, J Evans, J Stambas
(2014), Vol. 16, pp. 1-19, Expert reviews in molecular medicine, Cambridge, Eng., C1
miRNA modulation of SOCS1 using an influenza A virus delivery system
L Izzard, S Ye, K Jenkins, Y Xia, M Tizard, J Stambas
(2014), Vol. 95, pp. 1880-1885, Journal of general virology, Reading, England, C1
J Stambas, S Lowther, S Ye
(2014), Vol. 192, pp. 1-1, Journal of immunology, Bethesda, Md., C1-1
Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation
S Yatmaz, H Seow, R Gualano, Z Wong, J Stambas, S Selemidis, P Crack, S Bozinovski, G Anderson, R Vlahos
(2013), Vol. 48, pp. 17-26, American journal of respiratory cell and molecular biology, New York, N.Y., C1
J Reece, S Alcantara, S Gooneratne, S Jegaskanda, T Amaresena, C Fernandez, K Laurie, A Hurt, S O'Connor, M Harris, J Petravic, A Martyushev, A Grimm, M Davenport, J Stambas, R De Rose, S Kent
(2013), Vol. 87, pp. 4146-4160, Journal of virology, Washington, D. C., C1
Promotion of Hendra virus replication by microRNA 146a
C Stewart, G Marsh, K Jenkins, M Gantier, M Tizard, D Middleton, J Lowenthal, J Haining, L Izzard, T Gough, C Deffrasnes, J Stambas, R Robinson, H Heine, J Pallister, A Foord, A Bean, L Wang
(2013), Vol. 87, pp. 3782-3791, Journal of virology, Washington, D. C., C1
C Ranasinghe, S Trivedi, J Stambas, R Jackson
(2013), pp. 1-13, Mucosal immunology, London, England, C1
M Flórido, M Grima, C Gillis, Y Xia, S Turner, J Triccas, J Stambas, W Britton
(2013), Vol. 191, pp. 302-311, Journal of immunology, Baltimore, Md., C1
Comparison of influenza and SIV specific CD8 T cell responses in macaques
S Jegaskanda, J Reece, R De Rose, J Stambas, L Sullivan, A Brooks, S Kent, A Sexton
(2012), Vol. 7, pp. 1-16, PLoS one, San Francisco, CA, C1-1
C Ranasinghe, F Eyers, J Stambas, D Boyle, I Ramshaw, A Ramsay
(2011), Vol. 29, pp. 3008-3020, Vaccine, Oxford, England, C1-1
Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation
R Vlahos, J Stambas, S Bozinovski, B Broughton, G Drummond, S Selemidis
(2011), Vol. 7, pp. 1-12, PLoS Pathogens, San Francisco, Calif., C1
A gel-capture assay for characterizing the sialyl-glycan selectivity of influenza viruses
T Velkov, P Thompson, O El-Kabbani, F Lindh, J Stambas, S Rockman
(2011), Vol. 55, pp. 131-137, Acta virologica, Bratislava, Slovakia, C1
K Kedzierska, S Valkenburg, C Guillonneau, F Hubert, T Cukalac, J Curtis, J Stambas, H Scott, L Kedzierski, V Venturi, M Davenport
(2010), Vol. 40, pp. 849-858, European journal of immunology, Weinheim, Germany, C1-1
Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function
M Olson, B Russ, P Doherty, S Turner, J Stambas
(2010), Vol. 5, pp. 175-183, Future virology, London, England, C1
Timing of immune escape linked to success or failure of vaccination
J Reece, L Loh, S Alcantara, C Fernandez, J Stambas, A Sexton, R De Rose, J Petravic, M Davenport, S Kent
(2010), Vol. 5, pp. 1-7, Plos one, San Francisco, Calif., C1-1
T Cukalac, J Moffat, V Venturi, M Davenport, P Doherty, S Turner, J Stambas
(2009), Vol. 27, pp. 6755-6761, Vaccine, Oxford, England, C1-1
Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques
A Sexton, R De Rose, J Reece, S Alcantara, L Loh, J Moffat, K Laurie, A Hurt, P Doherty, S Turner, S Kent, J Stambas
(2009), Vol. 83, pp. 7619-7628, Journal of virology, Washington, DC, C1-1
HIV-1 vaccine development : tackling virus diversity with a multi-envelope cocktail
J Hurwitz, X Zhan, S Brown, M Bonsignori, J Stambas, T Lockey, R Sealy, S Surman, P Freiden, B Jones, L Martin, J Blanchard, K Slobod
(2008), Vol. 13, pp. 609-620, Frontiers in Bioscience, Tampa, U.S.A., C1-1
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity
K Kedzierska, N La Gruta, J Stambas, S Turner, P Doherty
(2008), Vol. 45, pp. 607-618, Molecular Immunology, Oxford, England, C1-1
A Miller, R Center, J Stambas, G Deliyannis, P Doherty, J Howard, S Turner, D Purcell
(2008), Vol. 26, pp. 5641-5648, Vaccine, Guildford, England, C1-1
J Stambas, C Guillonneau, K Kedzierska, J Mintern, P Doherty, N La Gruta
(2008), Vol. 120, pp. 186-196, Pharmacology and Therapeutics, Oxford, England, C1-1
K Kedzierska, J Stambas, M Jenkins, R Keating, S Turner, P Doherty
(2007), Vol. 104, pp. 9782-9787, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1-1
A question of self-preservation : immunopathology in influenza virus infection
N La Gruta, K Kedzierska, J Stambas, P Doherty
(2007), Vol. 85, pp. 85-92, Immunology and Cell Biology, Adelaide, S. Aust., C1-1
An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8+ T cells
J Stambas, P Doherty, S Turner
(2007), Vol. 178, pp. 1285-1292, The Journal of Immunology, Baltimore, Md., C1-1
A multi-vector, multi-envelope HIV-1 vaccine
J Hurwitz, X Zhan, S Brown, M Bonsignori, J Stambas, T Lockey, B Jones, S Surman, R Sealy, P Freiden, K Branum, K Slobod
(2007), Vol. 12, pp. 68-76, The Journal of pediatric pharmacology and therapeutics, Littleton, Colorado, C1-1
HIV vaccines : brief review and discussion of future directions
K Slobod, M Bonsignori, S Brown, X Zhan, J Stambas, J Hurwitz
(2005), Vol. 4, pp. 305-313, Expert Review of Vaccines, London, U.K., C1-1
HIV vaccine rationale, design and testing
K Slobod, C Coleclough, M Bonsignori, S Brown, X Zhan, S Surman, A Zirkel, B Jones, R Sealy, J Stambas, B Brown, T Lockey, P Freiden, P Doherty, J Blanchard, L Martin, J Hurwitz
(2005), Vol. 3, pp. 107-112, Current HIV research, The Netherlands, C1-1
Clade, country and region-specific HIV-1 vaccines : are they necessary?
K Slobod, C Coleclough, S Brown, J Stambas, X Zhan, S Surman, B Jones, A Zirkel, P Freiden, B Brown, R Sealy, M Bonsignori, J Hurwitz
(2005), Vol. 2, pp. 1-3, AIDS Research and Therapy, London, England, C1-1
S Andreansky, J Stambas, P Thomas, W Xie, R Webby, P Doherty
(2005), Vol. 79, pp. 4329-4339, Journal of Virology, Washington, D.C., C1-1
J Stambas, S Brown, A Gutierrez, R Sealy, W Yue, B Jones, T Lockey, A Zirkel, P Freiden, B Brown, S Surman, C Coleclough, K Slobod, P Doherty, J Hurwitz
(2005), Vol. 23, pp. 2454-2464, Vaccine, Guildford, England, C1-1
X Zhan, L Martin, K Slobod, C Coleclough, T Lockey, S Brown, J Stambas, M Bonsignori, R Sealy, J Blanchard, J Hurwitz
(2005), Vol. 23, pp. 5306-5320, Vaccine, Guildford, England, C1-1
Generation of recombinant influenza A viruses lacking immunodominant CD8+ T cell epitopes
S Andreansky, J Stambas, A Gutierrez, G Diaz, P Doherty, S Turner, R Webby
(2004), Vol. 1263, pp. 141-144, International Congress Series, The Netherlands, C1-1
S Turner, N La Gruta, J Stambas, G Diaz, P Doherty
(2004), Vol. 101, pp. 3545-3550, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1-1
S Brown, J Stambas, X Zhan, K Slobod, C Coleclough, A Zirkel, S Surman, S White, P Doherty, J Hurwitz
(2003), Vol. 171, pp. 4140-4148, The Journal of Immunology, Baltimore, Md., C1-1
Protection and compensation in the influenza virus-specific CD8+ T cell response.
R Webby, S Andreansky, J Stambas, J Rehg, R Webster, P Doherty, S Turner
(2003), Vol. 100, pp. 7235-7240, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1-1
Oxidised mannan as a novel adjuvant inducing mucosal IgA production.
J Stambas, G Pietersz, I McKenzie, C Cheers
(2002), Vol. 20, pp. 1068-1078, Vaccine, Guildford, England, C1-1
J Stambas, G Pietersz, I McKenzie, V Nagabhushanam, C Cheers
(2002), Vol. 20, pp. 1877-1886, Vaccine, Guildford, England, C1-1
Funded Projects at Deakin
Australian Competitive Grants
Identification of determinants associated with pathogenicity of Swine-Origin 2009 (H1N1) influenza virus
Prof John Stambas, A/Prof Stephen Stephen, Dr Deborah Middleton
NHMRC - H1N1 Influenza 09
- 2011: $30,809
- 2010: $68,985
Evaluation of immune correlates for virus-specific CD8+ T cells following prime-boost vaccination
Prof John Stambas
NHMRC Project Grant
- 2011: $2,064
- 2010: $159,691
Development of recombinant influenza-SIV vaccines
Prof John Stambas, Dr Robert De Rose
University of Melbourne - Aust Centre for HIV and Hepatitis Virology Research
- 2009: $66,000
Comparative effectiveness of vaccine-induced SIV-specific CD8 T cells
Prof Steven Kent, Prof John Stambas
NHMRC Project Grant
- 2012: $90,000
- 2011: $90,000
Understanding immunity in an encephalitic mouse model of Hendra virus infection
Prof John Stambas, Prof Paul Hertzog, Prof Carola Vinuesa, Dr Deborah Middleton, Dr Linfa Wang
NHMRC Hendra Virus Urgent Call for Research
- 2014: $90,600
- 2013: $28,305
- 2012: $187,450
Impact of Influenza A infection on T cell-mediated immunity to pulmonary tuberculosis
Prof Warwick Britton, Dr Jamie Triccas, Dr Manuela Florido, Prof John Stambas
NHMRC Project Grant
- 2013: $25,000
Development of apocynin as a new antiviral for emerging infectious diseases
Prof John Stambas
CSIRO Flagship Collaboration Research Fund - Commonwealth Scientific and Industrial Research Organisation
- 2013: $85,000
The role of extracellular matrix enzymes in influenza virus infection
Prof John Stambas, Prof Ralph Tripp, Prof Suneel Apte
NHMRC Project Grant
- 2022: $41,072
- 2021: $171,632
- 2020: $187,274
- 2019: $118,533
Other Public Sector Funding
The role of endothelium in the pathogenicity of H5N1 HPAI in chickens
Prof John Stambas, Ms Jasmina Luczo
CSIRO
- 2014: $14,000
- 2013: $28,000
- 2012: $42,000
- 2011: $14,000
Design and development of superior pan-diagnostics for Foot-and-Mouth Disease (FMD)
Prof John Stambas, Miss Alyssa Van Dreumel
CSIRO
- 2015: $2,136
- 2014: $4,272
- 2013: $4,272
- 2012: $4,272
Delivery of MIRNA Using Genetically Modified Influenza Virus
Prof John Stambas, Prof Alister Ward, Prof Ken Walder, Ms Yingju Xia
Victorian International Research Scholarships
- 2014: $60,000
Long term physical and psychological consequences of Covid-19 infection. A Comparitive Observational Study in Regional Victoria.
Prof Eugene Athan, Dr Darcie Cooper, Prof Peter Vuillermin, Dr Daniel O'Brien, Prof John Stambas, Prof Alister Ward, Prof Michael Berk, Prof Julie Pasco, A/Prof Alyssa Barry, Prof Soren Alexandersen
Department of Jobs, Precincts & Regions
- 2021: $228,000
Industry and Other Funding
Generation of recombinant influenza vaccines expressing exogenous miRNAs for increased in vitro vaccine production
Prof Ralph Tripp, Prof John Stambas
NIH Grant - Research - National Institutes of Health
- 2019: $8,600
- 2018: $30,268
- 2017: $24,823
CISH (cytokine-inducible SH2-containing protein): a biological universal remote for CD8+ T cell regulation
Prof John Stambas, Dr Daniel Dlugolenski
AAI Careers in Immunology Fellowships
- 2018: $31,950
- 2017: $26,101
Bioavailability and Bioactivity in a Model Skin System.
A/Prof Richard Williams, Dr Aaqil Rifai, Prof John Stambas, Prof Colin Barrow, Dr Dylan Hegh
Humble Bee Bio Pty Ltd
- 2023: $42,808
Other Funding Sources
Collaborative High Bio-Containment immunological Research Facility
Prof Alister Ward, Dr Linfa Wang, Prof John Stambas, Dr John Lowenthal, Prof Ralph Tripp, Prof Bill Buttemer, Prof Johnson Mak, Prof Tania De Koning-Ward
CSIRO Commonwealth Scientific and Industrial Research Organisation, ARC LIEF - Linkage Infrastructure Equipment & Facilities Program
- 2012: $105,000
- 2011: $100,000
Supervisions
Jessie Pedrina
Thesis entitled: Investigating the role of ADAMTS proteoglycanases in influenza virus immunity
Doctor of Philosophy (Medicine), School of Medicine
Shasha Zhao
Thesis entitled: The Role of miRNAs in Influenza Virus Pathogenesis and Immunity
Doctor of Philosophy (Medicine), School of Medicine
Qi Liu
Thesis entitled: Gene editing in chickens : Knockdown of Interleukin-6 using CRISPR
Doctor of Philosophy (Medicine), School of Medicine
Yingju Xia
Thesis entitled: Delivery of Immunomodulatory miRNAs Using Genetically Modified Influenza Viruses
Doctor of Philosophy (Medicine), School of Medicine
Meagan McMahon
Thesis entitled: The role of ADAMTS enzymes in influenza virus immunity
Doctor of Philosophy (Medicine), School of Medicine
Alyssa Van Dreumel
Thesis entitled: Design and development of Pan-serodiagnostics for Foot-and-mouth disease
Doctor of Philosophy (Medicine), School of Medicine
Jasmina Luczo
Thesis entitled: Pathogenesis of avian influenza: role of the haemagglutinin cleavage site motif
Doctor of Philosophy (Medicine), School of Medicine
Mohammed Jasim Mohammed Shallal
Thesis entitled: Recombinant Influenza virus as HIV vaccine vector
Doctor of Philosophy (Medicine), School of Medicine
Corinna Pade
Thesis entitled: Dissecting the early entry steps of HIV-1 infection
Doctor of Philosophy (Medicine), School of Medicine
Brian Clarke
Thesis entitled: Expression of anti-viral shRNA molecules in transgenic zebrafish
Doctor of Philosophy (Medicine), School of Medicine
Katherine Birrer
Thesis entitled: Silencing Host Genes Using RNAi to Impact Virus Growth in vitro Methods for reducing cotton wax.
MAppSc (Medicine) (High cost), School of Medicine