A/Prof. Mark Guthridge

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

T-C Teh, N-Y Nguyen, D Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, P Ekert, G Lessene, S Glaser, D Huang, A Roberts, M Guthridge, A Wei

(2018), Vol. 32, pp. 303-312, Leukemia, Berlin, Germany, C1-1

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald Cameron, Katherine Hannan, Nhu-Y Nguyen, Chun Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer Devlin, Amee George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon Harrison, James Rozario, Jason Powell, Stuart Pitson, Johannes Zuber, Ricky Johnstone, Mark Dawson, Mark Guthridge, Andrew Wei, Grant McArthur, Richard Pearson, Ross Hannan

(2017), Vol. 129, pp. 2882-2895, Blood, New York, N.Y., C1-1

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

N Lalaoui, K Hänggi, G Brumatti, D Chau, N Nguyen, L Vasilikos, L Spilgies, D Heckmann, C Ma, M Ghisi, J Salmon, G Matthews, E de Valle, D Moujalled, M Menon, S Spall, S Glaser, J Richmond, R Lock, S Condon, R Gugasyan, M Gaestel, M Guthridge, R Johnstone, L Munoz, A Wei, P Ekert, D Vaux, W Wong, J Silke

(2016), Vol. 29, pp. 145-158, Cancer Cell, United States, C1-1

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Amanda Smith, Matthew Dun, Erwin Lee, Celeste Harrison, Richard Kahl, Hayley Flanagan, Nikita Panicker, Baratali Mashkani, Anthony Don, Jonathan Morris, Hamish Toop, Richard Lock, Jason Powell, Daniel Thomas, Mark Guthridge, Andrew Moore, Leonie Ashman, Kathryn Skelding, Anoop Enjeti, Nicole Verrills

(2016), Vol. 7, pp. 47465-47478, Oncotarget, aLBANY, n.y., C1-1

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

Sewa Rijal, Shaun Fleming, Nik Cummings, Natalie Rynkiewicz, Lisa Ooms, Nhu-Y Nguyen, Tse-Chieh Teh, Sharon Avery, Julie McManus, Anthony Papenfuss, Catriona McLean, Mark Guthridge, Christina Mitchell, Andrew Wei

(2015), Vol. 125, pp. 2815-2824, Blood, Washington, D. C., C1

14-3-3ζ coordinates adipogenesis of visceral fat

Gareth Lim, Tobias Albrecht, Micah Piske, Karnjit Sarai, Jason Lee, Hayley Ramshaw, Sunita Sinha, Mark Guthridge, Amparo Acker-Palmer, Angel Lopez, Susanne Clee, Corey Nislow, James Johnson

(2015), Vol. 6, Nature communications, London, Eng., C1

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Louisa Phillipson, David Segal, Tracy Nero, Michael Parker, Soo Wan, Melanie de Silva, Mark Guthridge, Andrew Wei, Christopher Burns

(2015), Vol. 23, pp. 6280-6296, Bioorganic & medicinal chemistry, Amsterdam, The Netherlands, C1

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

Daniel Thomas, Jason Powell, Benjamin Green, Emma Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew Zannettino, Stuart Pitson, Timothy Hughes, Angel Lopez, Peter Shepherd, Andrew Wei, Paul Ekert, Mark Guthridge

(2013), Vol. 11, PLoS biology, San Francisco, Calif., C1-1

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase Cϵ regulates ras/mitogen-activated protein kinase signaling and neuronal differentiation

Ana Lonic, Jason Powell, Yang Kong, Daniel Thomas, Jessica Holien, Nhan Truong, Michael Parker, Mark Guthridge

(2013), Vol. 288, pp. 14874-14885, The journal of biological chemistry, Rockville, Md., C1-1

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason Powell, Francois Vergez, David Segal, Nhu-Y Nguyen, Adele Baker, Tse-Chieh Teh, Emma Barry, Jean-Emmanuel Sarry, Erwin Lee, Tracy Nero, Anissa Jabbour, Giovanna Pomilio, Benjamin Green, Stéphane Manenti, Stefan Glaser, Michael Parker, Angel Lopez, Paul Ekert, Richard Lock, David Huang, Susie Nilsson, Christian Récher, Andrew Wei, Mark Guthridge

(2013), Vol. 122, pp. 738-748, Blood, Washington, D.C., C1-1

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

B Green, A Jabbour, J Sandow, C Riffkin, D Masouras, C Daunt, M Salmanidis, G Brumatti, B Hemmings, M Guthridge, R Pearson, P Ekert

(2013), Vol. 20, pp. 1341-1349, Cell death & differentiation, Cham, Switzerland, C1-1

Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity

Christina Buchanan, James Dickson, Woo-Jeong Lee, Mark Guthridge, Jackie Kendall, Peter Shepherd

(2013), Vol. 8, PloS one, San Francisco, Calif., C1-1

The regulation of mitochondrial metabolism by the Bcl-2 family of pro-survival proteins: new therapeutic opportunities for targeting cancer cells

Mark Guthridge, Melissa Brown, Andrew Wei

(2013), Vol. 1, Journal of hematology & thromboembolic diseases, Hyderabad, India, C1-1

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

J Sandow, A Jabbour, M Condina, C Daunt, F Stomski, B Green, C Riffkin, P Hoffmann, M Guthridge, J Silke, A Lopez, P Ekert

(2012), Vol. 19, pp. 633-641, Cell Death and Differentiation, England, C1-1

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency

P Cheah, H Ramshaw, P Thomas, K Toyo-Oka, X Xu, S Martin, P Coyle, M Guthridge, F Stomski, M Van Den Buuse, A Wynshaw-Boris, A Lopez, Q Schwarz

(2012), Vol. 17, pp. 451-466, Molecular Psychiatry, England, C1-1

Molecular basis of cytokine receptor activation

A Lopez, T Hercus, P Ekert, D Littler, M Guthridge, D Thomas, H Ramshaw, F Stomski, M Perugini, R D'Andrea, M Grimbaldeston, M Parker

(2010), Vol. 62, pp. 509-518, IUBMB Life, England, C1-1

Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors

D Hiwase, D White, J Powell, V Saunders, S Zrim, A Frede, M Guthridge, A Lopez, R D'Andrea, L To, J Melo, S Kumar, T Hughes

(2010), Vol. 24, pp. 771-778, Leukemia, London, Eng., C1

Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers

Kathryn Roberts, Amanda Smith, Fiona McDougall, Helen Carpenter, Martin Horan, Paolo Neviani, Jason Powell, Daniel Thomas, Mark Guthridge, Danilo Perrotti, Alistair Sim, Leonie Ashman, Nicole Verrills

(2010), Vol. 70, pp. 5438-5447, Cancer Research, Philadelphia, Pa., C1

14-3-3:Shc Scaffolds integrate phosphoserine and phosphotyrosine Signaling to regulate phosphatidylinositol 3-kinase activation and cell survival

Emma Barry, Fernando Felquer, Jason Powell, Lisa Biggs, Frank Stomski, Andrea Urbani, Hayley Ramshaw, Peter Hoffmann, Matthew Wilce, Michele Grimbaldeston, Angel Lopez, Mark Guthridge

(2009), Vol. 284, pp. 12080-12090, Journal of Biological Chemistry, Bethesda, Md., C1

The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease

T Hercus, D Thomas, M Guthridge, P Ekert, J King-Scott, M Parker, A Lopez

(2009), Vol. 114, pp. 1289-1298, Blood, United States, C1-1

A sensitive magnetic bead method for the detection and identification of tyrosine phosphorylation in proteins by MALDI-TOF/TOF MS

Mark Condina, Mark Guthridge, Shaun McColl, Peter Hoffmann

(2009), Vol. 9, pp. 3047-3057, Proteomics, Weinheim, Germany, C1

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor ∝ chain, eliminates human acute myeloid lukemic stem cells

Liqing Jin, Erwin Lee, Hayley Ramshaw, Samantha Busfield, Armando Peoppl, Lucy Wilkinson, Mark Guthridge, Daniel Thomas, Emma Barry, Andrew Boyd, David Gearing, Gino Vairo, Angel Lopez, John Dick, Richard Lock

(2009), Vol. 5, pp. 31-42, Cell Stem Cell, Cambridge, Mass., C1

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

Jason Powell, Daniel Thomas, Emma Barry, Chung Kok, Barbara McClure, Anna Tsykin, L To, Anna Brown, Ian Lewis, Kirsten Herbert, Gregory Goodall, Terence Speed, Norio Asou, Bindya Jacob, Motomi Osato, David Haylock, Susan Nilsson, Richard D'Andrea, Angel Lopez, Mark Guthridge

(2009), Vol. 114, pp. 4859-4870, Blood, Washington, D.C., C1

Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation

Ana Lonic, Emma Barry, Cindy Quach, Bostjan Kobe, Neil Saunders, Mark Guthridge

(2008), Vol. 28, pp. 3372-3385, Molecular and Cellular Biology, Washington, D.C., C1

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

Guido Hansen, Timothy Hercus, Barbara McClure, Frank Stomski, Mara Dottore, Jason Powell, Hayley Ramshaw, Joanna Woodcock, Yibin Xu, Mark Guthridge, William McKinstry, Angel Lopez, Michael Parker

(2008), Vol. 134, pp. 496-507, Cell, Cambridge, Mass., C1

The Shc-binding site of the beta(c) subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis

Hayley Ramshaw, Mark Guthridge, Frank Stomski, Emma Barry, Lisa Ooms, Christina Mitchell, C Begley, Angel Lopez

(2007), Vol. 110, pp. 3582-3590, BLOOD, United States, C1

The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappa B and induction of bcl-2

M Guthridge, E Barry, F Felquer, B McClure, F Stomski, H Ramshaw, A Lopez

(2004), Vol. 103, pp. 820-827, BLOOD, United States, C1

Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins

M Olayioye, M Guthridge, F Stomski, A Lopez, J Visvader, G Lindeman

(2003), Vol. 278, pp. 32929-32935, JOURNAL OF BIOLOGICAL CHEMISTRY, United States, C1

Structural and functional hot spots in cytokine receptors

C Bagley, J Woodcock, M Guthridge, F Stomski, A Lopez

(2001), Vol. 73, pp. 299-307, INTERNATIONAL JOURNAL OF HEMATOLOGY, Japan, C1

Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival

M Guthridge, F Stomski, E Barry, W Winnall, J Woodcock, B McClure, M Dottore, M Berndt, A Lopez

(2000), Vol. 6, pp. 99-108, MOLECULAR CELL, United States, C1

Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF

F Stomski, M Dottore, W Winnall, M Guthridge, J Woodcock, C Bagley, D Thomas, R Andrews, M Berndt, A Lopez

(1999), Vol. 94, pp. 1933-1942, BLOOD, United States, C1

Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors

M Guthridge, F Stomski, D Thomas, J Woodcock, C Bagley, M Berndt, A Lopez

(1998), Vol. 16, pp. 301-313, Stem Cells, England, C1-1

FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression

M Guthridge, P Bellosta, N Tavoloni, C Basilico

(1997), Vol. 17, pp. 5485-5498, MOLECULAR AND CELLULAR BIOLOGY, United States, C1

Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts

M Guthridge, M Seldin, C Basilico

(1996), Vol. 12, pp. 1267-1278, ONCOGENE, England, C1

A NEW QUANTITATIVE POLYMERASE CHAIN-REACTION HIGH-PERFORMANCE ION-EXCHANGE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETECTION OF FIBROBLAST GROWTH-FACTOR-BETA (FGF-BETA) GENE AMPLIFICATION

J SCHMITT, M GUTHRIDGE, C ECONOMOU, J BERTOLINI, M HEARN

(1992), Vol. 24, pp. 119-133, JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, Netherlands, C1-1

Localization of bFGF mRNA in Cyclic Rat Ovary, Diethylstilbesterol Primed Rat Ovary, and Cultured Rat Granulosa Cells

M Guthridge, J Bertolini, J Cowling, M Hearn

(1992), Vol. 7, pp. 15-25, GROWTH FACTORS, England, C1-1

Studies on basic fibroblast growth factor (FGF-beta) gene expression in the rat and pig ovary using in situ hybridization and quantitative reverse transcriptase--polymerase chain reaction techniques.

M Guthridge, J Schmitt, J Bertolini, J Cowling, A Runting, S Katsahambas, A Drummond, M Hearn

(1992), Vol. 61, pp. 219-229, Angiogenesis, Basel, Switzerland, C1-1

The Role of Basic Fibroblast Growth Factor in Skeletal Muscle Regeneration

Mark Guthridge, Michael Wilson, Jane Cowling, Joseph Bertolini, Milton Hearn

(1992), Vol. 6, GROWTH FACTORS, England, C1-1

DETECTION OF FGF-BETA MESSENGER-RNA IN CHONDROSARCOMA CELLS BY A NEW INSITU HYBRIDIZATION TECHNIQUE WITH SYNTHETIC OLIGONUCLEOTIDE PROBES

M GUTHRIDGE, J BERTOLINI, J SCHMITT, M HEARN

(1991), Vol. 22, pp. 279-288, JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, Netherlands, C1-1

HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF AMINO-ACIDS, PEPTIDES, PROTEINS AND POLYNUCLEOTIDES .94. SOLID-PHASE HYBRIDIZATION OF COMPLEMENTARY OLIGONUCLEOTIDES

M GUTHRIDGE, J BERTOLINI, M HEARN

(1989), Vol. 476, pp. 445-453, JOURNAL OF CHROMATOGRAPHY, Netherlands, C1-1

HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF AMINO-ACIDS, PEPTIDES AND PROTEINS .74. SEPARATION OF HEPARIN-BINDING GROWTH-FACTORS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

M HEARN, M GUTHRIDGE, J BERTOLINI

(1987), Vol. 397, pp. 371-378, JOURNAL OF CHROMATOGRAPHY, Netherlands, C1-1