Dr Mark Guthridge

STAFF PROFILE

Position

Associate Professor, Biomedical Science

Faculty

Faculty of Sci Eng & Built Env

Department

School of Life & Env. Sciences

Campus

Melbourne Burwood Campus

Contact

m.guthridge@deakin.edu.au
+61 3 924 45796

Publications

Filter by

2018

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

T-C Teh, N-Y Nguyen, D Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, P Ekert, G Lessene, S Glaser, D Huang, A Roberts, M Guthridge, A Wei

(2018), Vol. 32, pp. 303-312, Leukemia, Berlin, Germany, C1-1

journal
2017

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald Cameron, Katherine Hannan, Nhu-Y Nguyen, Chun Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer Devlin, Amee George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon Harrison, James Rozario, Jason Powell, Stuart Pitson, Johannes Zuber, Ricky Johnstone, Mark Dawson, Mark Guthridge, Andrew Wei, Grant McArthur, Richard Pearson, Ross Hannan

(2017), Vol. 129, pp. 2882-2895, Blood, New York, N.Y., C1-1

journal
2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Hnggi, Gabriela Brumatti, Diep Chau, Nhu-Y Nguyen, Lazaros Vasilikos, Lisanne Spilgies, Denise Heckmann, Chunyan Ma, Margherita Ghisi, Jessica Salmon, Geoffrey Matthews, Elisha deValle, Donia Moujalled, Manoj Menon, Sukhdeep Spall, Stefan Glaser, Jennifer Richmond, Richard Lock, Stephen Condon, Raffi Gugasyan, Matthias Gaestel, Mark Guthridge, Ricky Johnstone, Lenka Munoz, Andrew Wei, Paul Ekert, David Vaux, W Wong, John Silke

(2016), Vol. 29, pp. 145-158, Cancer Cell, Cambridge, Mass., C1-1

journal

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Amanda Smith, Matthew Dun, Erwin Lee, Celeste Harrison, Richard Kahl, Hayley Flanagan, Nikita Panicker, Baratali Mashkani, Anthony Don, Jonathan Morris, Hamish Toop, Richard Lock, Jason Powell, Daniel Thomas, Mark Guthridge, Andrew Moore, Leonie Ashman, Kathryn Skelding, Anoop Enjeti, Nicole Verrills

(2016), Vol. 7, pp. 47465-47478, Oncotarget, aLBANY, n.y., C1-1

journal
2015

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

Sewa Rijal, Shaun Fleming, Nik Cummings, Natalie Rynkiewicz, Lisa Ooms, Nhu-Y Nguyen, Tse-Chieh Teh, Sharon Avery, Julie McManus, Anthony Papenfuss, Catriona McLean, Mark Guthridge, Christina Mitchell, Andrew Wei

(2015), Vol. 125, pp. 2815-2824, Blood, Washington, D. C., C1

journal

14-3-3? coordinates adipogenesis of visceral fat

Gareth Lim, Tobias Albrecht, Micah Piske, Karnjit Sarai, Jason Lee, Hayley Ramshaw, Sunita Sinha, Mark Guthridge, Amparo Acker-Palmer, Angel Lopez, Susanne Clee, Corey Nislow, James Johnson

(2015), Vol. 6, Nature communications, London, Eng., C1

journal

Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9

Louisa Phillipson, David Segal, Tracy Nero, Michael Parker, Soo Wan, Melanie de Silva, Mark Guthridge, Andrew Wei, Christopher Burns

(2015), Vol. 23, pp. 6280-6296, Bioorganic & medicinal chemistry, Amsterdam, The Netherlands, C1

journal
2013

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

Daniel Thomas, Jason Powell, Benjamin Green, Emma Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew Zannettino, Stuart Pitson, Timothy Hughes, Angel Lopez, Peter Shepherd, Andrew Wei, Paul Ekert, Mark Guthridge

(2013), Vol. 11, PLoS biology, San Francisco, Calif., C1-1

journal

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C? regulates ras/mitogen-activated protein kinase signaling and neuronal differentiation

Ana Lonic, Jason Powell, Yang Kong, Daniel Thomas, Jessica Holien, Nhan Truong, Michael Parker, Mark Guthridge

(2013), Vol. 288, pp. 14874-14885, The journal of biological chemistry, Rockville, Md., C1-1

journal

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason Powell, Francois Vergez, David Segal, Nhu-Y Nguyen, Adele Baker, Tse-Chieh Teh, Emma Barry, Jean-Emmanuel Sarry, Erwin Lee, Tracy Nero, Anissa Jabbour, Giovanna Pomilio, Benjamin Green, Stphane Manenti, Stefan Glaser, Michael Parker, Angel Lopez, Paul Ekert, Richard Lock, David Huang, Susie Nilsson, Christian Rcher, Andrew Wei, Mark Guthridge

(2013), Vol. 122, pp. 738-748, Blood, Washington, D.C., C1-1

journal

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

B Green, A Jabbour, J Sandow, C Riffkin, D Masouras, C Daunt, M Salmanidis, G Brumatti, B Hemmings, M Guthridge, R Pearson, P Ekert

(2013), Vol. 20, pp. 1341-1349, Cell death & differentiation, Cham, Switzerland, C1-1

journal

Oncogenic mutations of p110? isoform of PI 3-kinase upregulate its protein kinase activity

Christina Buchanan, James Dickson, Woo-Jeong Lee, Mark Guthridge, Jackie Kendall, Peter Shepherd

(2013), Vol. 8, PloS one, San Francisco, Calif., C1-1

journal

The regulation of mitochondrial metabolism by the Bcl-2 family of pro-survival proteins: new therapeutic opportunities for targeting cancer cells

Mark Guthridge, Melissa Brown, Andrew Wei

(2013), Vol. 1, Journal of hematology & thromboembolic diseases, Hyderabad, India, C1-1

journal

Funded Projects at Deakin

No Funded Projects at Deakin found

Supervisions

No completed student supervisions to report