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A/Prof. Richard Williams

STAFF PROFILE

Position

Associate Professor

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy, University of Manchester, 2009
Master of Science, University of Birmingham, 2005
Bachelor of Science, University of Reading, 2001

Contact

Biography

Dr Williams, after stints at the Medical Research Council and the Forensic Science service, completed a PhD in Materials Science at the University of Manchester. He then took up a Postdoctoral Fellowship in the Biomaterials Theme of CSIRO Molecular and Health Technologies  in Melbourne Australia. Following that, he was awarded a prestigious Alfred Deakin Research Fellowship (2012-2014).

He is currently a Senior Lecturer in Medical Biotechnology in the School of Medicine.

Read more on Richard's profile

Research interests

Self Assembled Materials for regenerative medicine

Media appearances

https://www.sbs.com.au/news/seaweed-may-help-heal-injured-brain-tissue-australian-research-finds

https://www.youtube.com/watch?v=i2C4d34JXZ8

Publications

Filter by

2022

Hybrid Self-Assembling Peptide/Gelatin Methacrylate (GelMA) Bioink Blend for Improved BioPrintability and Primary Myoblast Response

Mitchell Boyd-Moss, Kate Firipis, Anita Quigley, Aaqil Rifai, Artur Cichocki, Sarah Whitty, Catherine Ngan, Chaitali Dekiwadia, Benjamin Long, David Nisbet, Robert Kapsa, Richard Williams

(2022), Vol. 2, pp. 1-14, Advanced NanoBiomed Research, Weinheim, Germany, C1

journal article

Using UV-Responsive Nanoparticles to Provide In Situ Control of Growth Factor Delivery and a More Constant Release Profile from a Hydrogel Environment.

K Bruggeman, M Zhang, N Malagutti, S Soltani Dehnavi, R Williams, A Tricoli, D Nisbet

(2022), Vol. 14, pp. 12068-12076, ACS Applied Materials and Interfaces, Washington, DC, C1

journal article

Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials

Shiva Dehnavi, Zahra Zadeh, Alan Harvey, Nicolas Voelcker, Clare Parish, Richard Williams, Roey Elnathan, David Nisbet

(2022), pp. 1-70, Advanced Materials, London, Eng., C1

journal article

A Hydrogel as a Bespoke Delivery Platform for Stromal Cell-Derived Factor-1

Y Wang, V Penna, R Williams, C Parish, D Nisbet

(2022), Vol. 8, pp. 1-12, Gels, Basel, Switzerland, C1

journal article

Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease

V Penna, N Moriarty, Y Wang, K Law, C Gantner, R Williams, D Nisbet, C Parish

(2022), Vol. 23, pp. 1-16, International Journal of Molecular Sciences, Basel, Switzerland, C1

journal article

Biodesigned bioinks for 3D printing via divalent crosslinking of self-assembled peptide-polysaccharide hybrids

K Firipis, E Footner, M Boyd-Moss, C Dekiwadia, D Nisbet, R Kapsa, E Pirogova, R Williams, A Quigley

(2022), Vol. 14, pp. 1-14, Materials Today Advances, Amsterdam, The Netherlands, C1

journal article

Traction of 3D and 4D Printing in the Healthcare Industry: From Drug Delivery and Analysis to Regenerative Medicine

Karim Osouli-Bostanabad, Tahereh Masalehdan, Robert Kapsa, Anita Quigley, Aikaterini Lalatsa, Kiara Bruggeman, Stephanie Franks, Richard Williams, David Nisbet

(2022), Vol. 8, pp. 2764-2797, ACS Biomaterials Science & Engineering, Washington, D.C., C1

journal article
2021

Peptide Hydrogel Scaffold for Mesenchymal Precursor Cells Implanted to Injured Adult Rat Spinal Cord

T Wiseman, D Baron-Heeris, I Houwers, R Keenan, R Williams, D Nisbet, A Harvey, S Hodgetts

(2021), Vol. 27, pp. 993-1007, Tissue Engineering - Part A, United States, C1

journal article

Is Viral Vector Gene Delivery More Effective Using Biomaterials?

Y Wang, K Bruggeman, S Franks, V Gautam, S Hodgetts, A Harvey, R Williams, D Nisbet

(2021), Vol. 10, Advanced Healthcare Materials, Germany, C1

journal article

Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice

L Voglsanger, J Read, S Ch’ng, C Zhang, I Eraslan, L Gray, L Rivera, L Hamilton, R Williams, A Gundlach, C Smith

(2021), Vol. 14, Frontiers in Neuroscience, Switzerland, C1

journal article

Tuneable hybrid hydrogels via complementary self-assembly of a bioactive peptide with a robust polysaccharide

K Firipis, M Boyd-Moss, B Long, C Dekiwadia, W Hoskin, E Pirogova, D Nisbet, R Kapsa, A Quigley, R Williams

(2021), Vol. 7, pp. 3340-3350, ACS Biomaterials Science and Engineering, United States, C1

journal article

Replace and repair: Biomimetic bioprinting for effective muscle engineering

C Blake, O Massey, M Boyd-Moss, K Firipis, A Rifai, S Franks, A Quigley, R Kapsa, D Nisbet, R Williams

(2021), Vol. 5, APL Bioengineering, United States, C1

journal article

Tissue Programmed Hydrogels Functionalized with GDNF Improve Human Neural Grafts in Parkinson's Disease

C Hunt, V Penna, C Gantner, N Moriarty, Y Wang, S Franks, C Ermine, I de Luzy, C Pavan, B Long, R Williams, L Thompson, D Nisbet, C Parish

(2021), Vol. 31, Advanced Functional Materials, C1

journal article

Towards bioengineered skeletal muscle: Recent developments in vitro and in vivo

A Quigley, C Ngan, K Firipis, C O'Connell, E Pirogova, S Moulton, R Williams, R Kapsa

(2021), Vol. 65, pp. 555-567, Essays in Biochemistry, England, C1

journal article

Enhancing peptide biomaterials for biofabrication

K Firipis, D Nisbet, S Franks, R Kapsa, E Pirogova, R Williams, A Quigley

(2021), Vol. 13, pp. 2590-2590, Polymers, Basel, Switzerland, C1

journal article

Osteoblast Cell Response on Polycrystalline Diamond-Coated Additively Manufactured Scaffolds

A Rifai, N Tran, V Leitch, M Booth, R Williams, K Fox

(2021), Vol. 4, pp. 7509-7516, ACS Applied Bio Materials, Washington, D.C., C1

journal article

Shining a light on the hidden structure of gelatin methacryloyl bioinks using small-angle X-ray scattering (SAXS)

M Boyd-Moss, K Firipis, C O'Connell, A Rifai, A Quigley, G Boer, B Long, D Nisbet, R Williams

(2021), Vol. 5, pp. 8025-8036, Materials Chemistry Frontiers, C1

journal article

Matured myofibers in bioprinted constructs with in vivo vascularization and innervation

C Ngan, A Quigley, R Williams, C O’connell, R Blanchard, M Boyd-Moss, T Aumann, P McKelvie, G Wallace, P Choong, R Kapsa

(2021), Vol. 7, Gels, Switzerland, C1

journal article
2020

Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment

A Cembran, K Bruggeman, R Williams, C Parish, D Nisbet

(2020), Vol. 23, iScience, United States, C1

journal article

Harnessing the self-assembly of peptides for the targeted delivery of anti-cancer agents

S Franks, K Firipis, R Ferreira, K Hannan, R Williams, R Hannan, D Nisbet

(2020), Vol. 7, pp. 1996-2010, Materials horizons, Cambridge, Eng., C1

journal article

Cytotoxic T cells swarm by homotypic chemokine signalling

J Niño, S Pageon, S Tay, F Colakoglu, D Kempe, J Hywood, J Mazalo, J Cremasco, M Govendir, L Dagley, K Hsu, S Rizzetto, J Zieba, G Rice, V Prior, G O’neill, R Williams, D Nisbet, B Kramer, A Webb, F Luciani, M Read, M Biro

(2020), Vol. 9, pp. 1-71, eLife, England, C1

journal article
2019

Rational design of additively manufactured Ti6Al4V implants to control Staphylococcus aureus biofilm formation

A Sarker, N Tran, A Rifai, M Brandt, P Tran, M Leary, K Fox, R Williams

(2019), Vol. 5, Materialia, C1

journal article

Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo

C Ngan, C O'Connell, R Blanchard, M Boyd-Moss, R Williams, J Bourke, A Quigley, P McKelvie, R Kapsa, P Choong

(2019), Vol. 14, Biomedical Materials (Bristol), England, C1

journal article

Peptide programmed hydrogels as safe sanctuary microenvironments for cell transplantation

Y Wang, X He, K Bruggeman, B Gayen, A Tricoli, W Lee, R Williams, D Nisbet

(2019), Vol. 30, pp. 1-11, Advanced functional materials, Chichester, Eng., C1

journal article
2018

Large and small assembly: combining functional macromolecules with small peptides to control the morphology of skeletal muscle progenitor cells

R Li, N McRae, D McCulloch, M Boyd-Moss, C Barrow, D Nisbet, N Stupka, R Williams

(2018), Vol. 19, pp. 825-837, Biomacromolecules, Washington, D.C., C1

journal article

Scaffolds formed via the non-equilibrium supramolecular assembly of the synergistic ECM peptides RGD and PHSRN demonstrate improved cell attachment in 3D

S Aye, R Li, M Boyd-Moss, B Long, S Pavuluri, K Bruggeman, Y Wang, C Barrow, D Nisbet, R Williams

(2018), Vol. 10, Polymers, Switzerland, C1

journal article

A Programmed Anti-Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response

F Maclean, G Ims, M Horne, R Williams, D Nisbet

(2018), Vol. 30, Advanced Materials, Germany, C1

journal article

Nanostructured biomedical selenium at the biological interface (Review)

V Tan, A Hinchman, R Williams, P Tran, K Fox

(2018), Vol. 13, Biointerphases, United States, C1

journal article

Angle defines attachment: Switching the biological response to titanium interfaces by modifying the inclination angle during selective laser melting

A Sarker, N Tran, A Rifai, J Elambasseril, M Brandt, R Williams, M Leary, K Fox

(2018), Vol. 154, pp. 326-339, Materials and design, Amsterdam, The Netherlands, C1

journal article

Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials

K Bruggeman, R Williams, D Nisbet

(2018), Vol. 7, Advanced Healthcare Materials, Germany, C1

journal article

Using minimalist self-assembling peptides as hierarchical scaffolds to stabilise growth factors and promote stem cell integration in the injured brain

A Rodriguez, K Bruggeman, Y Wang, T Wang, R Williams, C Parish, D Nisbet

(2018), Vol. 12, pp. e1571-e1579, Journal of Tissue Engineering and Regenerative Medicine, England, C1

journal article

Hydrogel-immobilized supercharged proteins

E Campbell, J Grant, Y Wang, M Sandhu, R Williams, D Nisbet, A Perriman, D Lupton, C Jackson

(2018), Vol. 2, pp. 1-11, Advanced biosystems, Chichester, Eng., C1

journal article

Shear containment of BDNF within molecular hydrogels promotes human stem cell engraftment and postinfarction remodeling in stroke

D Nisbet, T Wang, K Bruggeman, J Niclis, F Somaa, V Penna, C Hunt, Y Wang, J Kauhausen, R Williams, L Thompson, C Parish

(2018), Vol. 2, pp. 1-13, Advanced biosystems, Chichester, Eng., C1

journal article

Review: Biomaterial systems to resolve brain inflammation after traumatic injury

Francesca Maclean, Malcolm Horne, Richard Williams, David Nisbet

(2018), Vol. 2, pp. 021502-021502, APL Bioengineering, Melville, N.Y., C1

journal article
2017

Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

R Li, M Boyd-Moss, B Long, A Martel, A Parnell, A Dennison, C Barrow, D Nisbet, R Williams

(2017), Vol. 7, Scientific Reports, England, C1

journal article

Bioprinting and biofabrication with peptide and protein biomaterials

M Boyd-Moss, K Fox, M Brandt, D Nisbet, R Williams

(2017), Vol. 1030, pp. 95-129, Advances in Experimental Medicine and Biology, United States, C1

journal article

Reducing Astrocytic Scarring after Traumatic Brain Injury with a Multifaceted Anti-Inflammatory Hydrogel System

F Maclean, Y Wang, R Walker, M Horne, R Williams, D Nisbet

(2017), Vol. 3, pp. 2542-2549, ACS Biomaterials Science and Engineering, United States, C1

journal article

Temporally controlled growth factor delivery from a self-assembling peptide hydrogel and electrospun nanofibre composite scaffold

K Bruggeman, Y Wang, F Maclean, C Parish, R Williams, D Nisbet

(2017), Vol. 9, pp. 13661-13669, Nanoscale, England, C1

journal article

Peptide-based scaffolds support human cortical progenitor graft integration to reduce atrophy and promote functional repair in a model of stroke

Fahad Somaa, Ting-Yi Wang, Jonathan Niclis, Kiara Bruggeman, Jessica Kauhausen, Haoyao Guo, Stuart McDougall, Richard Williams, David Nisbet, Lachlan Thompson, Clare Parish

(2017), Vol. 20, pp. 1964-1977, Cell reports, Amsterdam, The Netherlands, C1

journal article
2016

Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells

R Li, S Pavuluri, K Bruggeman, B Long, A Parnell, A Martel, S Parnell, F Pfeffer, A Dennison, K Nicholas, C Barrow, D Nisbet, R Williams

(2016), Vol. 12, pp. 1397-1407, Nanomedicine: Nanotechnology, Biology, and Medicine, United States, C1

journal article

Characterisation of minimalist co-assembled fluorenylmethyloxycarbonyl self-assembling peptide systems for presentation of multiple bioactive peptides

C Horgan, A Rodriguez, R Li, K Bruggeman, N Stupka, J Raynes, L Day, J White, R Williams, D Nisbet

(2016), Vol. 38, pp. 11-22, Acta biomaterialia, Amsterdam, The Netherlands, C1

journal article

Tailoring minimalist self-assembling peptides for localized viral vector gene delivery

A Rodriguez, T Wang, K Bruggeman, R Li, R Williams, C Parish, D Nisbet

(2016), Vol. 9, pp. 674-684, Nano research, Berlin, Germany, C1

journal article

A Commentary on the Need for 3D-Biologically Relevant In Vitro Environments to Investigate Astrocytes and Their Role in Central Nervous System Inflammation

F Maclean, R Williams, M Horne, D Nisbet

(2016), Vol. 41, pp. 589-592, Neurochemical Research, United States, C1

journal article

Temporally controlled release of multiple growth factors from a self-assembling peptide hydrogel

K Bruggeman, A Rodriguez, C Parish, R Williams, D Nisbet

(2016), Vol. 27, Nanotechnology, England, C1

journal article

Automated fourier space region-recognition filtering for off-axis digital holographic microscopy

X He, C Nguyen, M Pratap, Y Zheng, Y Wang, D Nisbet, R Williams, M Rug, A Maier, W Lee

(2016), Vol. 7, pp. 3111-3123, Biomedical Optics Express, United States, C1

journal article

Integrating Biomaterials and Stem Cells for Neural Regeneration

F Maclean, A Rodriguez, C Parish, R Williams, D Nisbet

(2016), Vol. 25, pp. 214-226, Stem Cells and Development, United States, C1

journal article
2015

Self-assembled peptide nanostructures for the fabrication of cell scaffolds

R Li, A Rodriguez, D Nisbet, C Barrow, R Williams

(2015), pp. 33-61, Micro and nanofabrication using self-assembled biological nanostructures, Amsterdam, The Netherlands, B1

book chapter

Tuning the mechanical and morphological properties of self-assembled peptide hydrogels via control over the gelation mechanism through regulation of ionic strength and the rate of pH change

R Li, C Horgan, B Long, A Rodriguez, L Mather, C Barrow, D Nisbet, R Williams

(2015), Vol. 5, pp. 301-307, RSC advances, Cambridge, Eng., C1

journal article

Organogelators based on the norbornane scaffold

S Hickey, S Hickey, S Tripcony, S Tripcony, R Li, R Li, R Williams, R Williams, F Pfeffer, F Pfeffer

(2015), Vol. 27, pp. 425-435, Supramolecular chemistry, Oxford, Eng., C1

journal article
2014

In vitro response to functionalized self-assembled peptide scaffolds for three-dimensional cell culture

V Modepalli, A Rodriguez, R Li, S Pavuluri, K Nicholas, C Barrow, D Nisbet, R Williams

(2014), Vol. 102, pp. 197-205, Biopolymers - Peptide Science Section, C1

journal article

In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair

A Rodriguez, T Wang, K Bruggeman, C Horgan, R Li, R Williams, C Parish, D Nisbet

(2014), Vol. 2, pp. 7771-7778, Journal of materials chemistry B, Cambridge, Eng., C1

journal article
2013

Monitoring the early stage self-assembly of enzyme-assisted peptide hydrogels

R Williams, J Gardiner, A Sorensen, S Marchesan, R Mulder, K McLean, P Hartley

(2013), Vol. 66, pp. 572-578, Australian journal of chemistry, Melbourne, Vic., C1

journal article

Tuning the amino acid sequence of minimalist peptides to present biological signals via charge neutralised self assembly

A Rodriguez, C Parish, D Nisbet, R Williams

(2013), Vol. 9, pp. 3915-3919, Soft matter, Cambridge, England, C1

journal article
2012

One step multifunctional micropatterning of surfaces using asymmetric glow discharge plasma polymerization

D Menzies, T Gengenbach, J Forsythe, N Birbilis, G Johnson, C Charles, G McFarland, R Williams, C Fong, P Leech, K McLean, B Muir

(2012), Vol. 48, pp. 1907-1909, Chemical communications, Cambridge, England, C1

journal article

Self-assembled peptides : characterisation and in vivo response

D Nisbet, R Williams

(2012), Vol. 7, pp. 1-14, Biointerphases, New York, N. Y., C1

journal article
2011

The in vivo performance of an enzyme-assisted self-assembled peptide/protein hydrogel

R Williams, T Hall, V Glattauer, J White, P Pasic, A Sorensen, L Waddington, K McLean, P Currie, P Hartley

(2011), Vol. 32, pp. 5304-5310, Biomaterials, Amsterdam, The Netherlands, C1-1

journal article
2010

Biocatalysed peptide hydrogels : an investigation of self-assembly kinetics using NMR spectroscopy

A Sorensen, P Hartley, R Williams

(2010), Vol. 20, pp. 243-243, European cells and materials, Clavadelstr, Davos, C1-1

journal article

Exploiting biocatalysis in peptide self-assembly

R Williams, R Mart, R Ulijn

(2010), Vol. 94, pp. 107-117, Peptide science, London, England, C1-1

journal article
2009

Enzyme-assisted self-assembly under thermodynamic control

R Williams, A Smith, R Collins, N Hodson, A Das, R Ulijn

(2009), Vol. 4, pp. 19-24, Nature nanotechnology, London, England, C1-1

journal article
2008

Bio-responsive hydrogels for biomedical applications

T McDonald, A Patrick, R Williams, B Cousins, V Ulijn Rein

(2008), pp. 43-59, Biomedical applications of electroactive polymer actuators, London, England, B1-1

book chapter

Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π-π interlocked β-sheets

A Smith, R Williams, C Tang, P Coppo, R Collins, M Turner, A Saiani, R Ulijn

(2008), Vol. 20, pp. 37-41, Advanced materials, Weinheim, Germany, C1-1

journal article
2006

Enzyme-triggered self-assembly of peptide hydrogels via reversed hydrolysis

S Toledano, R Williams, V Jayawarna, R Ulijn

(2006), Vol. 128, pp. 1070-1071, Journal of the American chemical society, Washington, D. C., C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Generating multi-component scaffolding to influence the differentiation of embryonic stem cells

Dr David Nesbit, Dr Clare Parish, A/Prof Richard Williams

ARC - Discovery Projects

  • 2014: $40,000
  • 2013: $40,000

Biomaterials for the direct reprograming of reactive astrocytes into functional neurons

Dr David Nisbet, Dr Clare Parish, A/Prof Richard Williams, Prof Alan Harvey, Dr Vincent Daria

NHMRC Project Grant

  • 2020: $30,000
  • 2019: $44,386

Using Stem Cells and Oxygen Vectors to Enhance Graft Integration in Parkinson's Disease

Prof Colin Jackson, A/Prof Richard Williams

NHMRC - Ideas Grant

  • 2021: $20,000
  • 2020: $20,000

Autologous Constructs for Muscle Engineering and Repair

Prof Robert Kapsa, Dr Anita Quigley, A/Prof Richard Williams, Dr Catherine Ngan, Prof Simon Moulton, Dr Cathal O'Connell

NHMRC - Ideas Grant

  • 2022: $37,140
  • 2021: $37,140

Industry and Other Funding

Biofabricated Synthetic Brain Tissue for Cruelty-Free Drug Testing on the Bench

A/Prof Richard Williams

CASS Grant - Research - The CASS Foundation Limited

  • 2022: $60,000

Other Funding Sources

Harvard Syringe pumps and high pressure syringes

A/Prof Richard Williams

NHMRC - Equipment Grant - Not R&D income countable (2017-current)

  • 2022: $16,385

Supervisions

Principal Supervisor
2021

Aseel Mahmood Ibrahim Al-Mashahedah

Thesis entitled: Nanoparticle Therapeutics to Target Corneal Scarring, Haze, and Bacterial Keratitis

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2022

Tulika Basak

Thesis entitled: Targeting iron overload: A potential approach towards glioblastoma therapy

Doctor of Philosophy (Medicine), School of Medicine

2021

Lara Voglsanger

Thesis entitled: The relaxin-3 system in the mouse brain and gut

Master of Philosophy (Medicine), School of Medicine

Naznin Akhtar

Thesis entitled: Theranostic Applications of Zinc Ferrite Nanoparticles for Colorectal Cancer

Doctor of Philosophy (Medicine), School of Medicine