Dr Roxana Llanos

STAFF PROFILE

Position

Visitor

Faculty

Faculty of Sci Eng & Built Env

Department

School of Life & Env. Sciences

Campus

Melbourne Burwood Campus

Qualifications

Doctor of Philosophy, University of Melbourne, 1995
Bachelor of Science, Monash University, 1987

Contact

roxana.llanos@deakin.edu.au
+61 3 924 45431

Biography summary

I have been involved in several research projects since the completion of a BSc (Honours) degree in 1986 and a PhD project in March 1995.  These include the immunological identification of Campylobacter generic probes from a C. jejuni genomic library (1987-1988, Monash University); cloning, mapping and expression of genes which encode key enzymes in the conversion of hexoses to lactic acid in Lactococcus lactis (1989-1996, The University of Melbourne); study of the molecular basis of microtubule nucleation, characterization of centrosomal components and the involvement of γ tubulin in this nucleation process (1996-1998, Grenoble, France); study of mammalian copper metabolism using cell and mouse models (2000 - 2015, Deakin University) and study of cell cycle genes involvement in excitotoxic neuronal death (2012 - present, Deakin University).

Knowledge areas

Protein trafficking/Protein localisation

Generation of transgenic mice

Mouse models with altered expression of copper transport genes

Menkes disease/Wilson disease/Neuropathy

Excitotoxicity/Neuronal cell death

Publications

Filter by

2019

Transactive response DNA-binding protein 43 abnormalities after traumatic brain injury

Xin Tan, Mujun Sun, Rhys Brady, Shijie Liu, Roxana Llanos, Steve Cheung, David Wright, Pablo Casillas-Espinosa, Maithili Sashindranath, Terence O'Brien, Stuart McDonald, Bradley Turner, Sandy Shultz

(2019), Vol. 36, pp. 87-99, Journal of neurotrauma, New Rochelle, N.Y., C1

journal article
2016

Comparative microarray analysis identifies commonalities in neuronal injury: evidence for oxidative stress, dysfunction of calcium signalling, and inhibition of autophagy-lysosomal pathway

Y Yap, R Llanos, S La Fontaine, M Cater, P Beart, N Cheung

(2016), Vol. 41, pp. 554-567, Neurochemical research, New York, N.Y., C1

journal article

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution

D Denoyer, H Pearson, S Clatworthy, Z Smith, P Francis, R Llanos, I Volitakis, W Phillips, P Meggyesy, S Masaldan, M Cater

(2016), Vol. 7, pp. 37064-37080, Oncotarget, Albany, N.Y., C1

journal article

Characterizing the molecular phenotype of an Atp7a(T985I) conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX)

G Perez-Siles, A Grant, M Ellis, C Ly, A Kidambi, M Khalil, R Llanos, S La Fontaine, A Strickland, S Zchner, S Bermeo, E Neist, T Brennan-Speranza, R Takata, C Speck-Martins, J Mercer, G Nicholson, M Kennerson

(2016), pp. 981-882, Metallomics: integrated biometal science, Cambridge, Eng., C1

journal article
2014

Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation

J Wadwa, Y Chu, N Nguyen, T Henson, A Figueroa, R Llanos, M Ackland, A Michalczyk, H Fullriede, G Brennan, J Mercer, M Linder

(2014), Vol. 2, pp. 1-11, Physiological Reports, Oxford, United Kingdom, C1

journal article

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis

B Roberts, N Lim, E McAllum, P Donnelly, D Hare, P Doble, B Turner, K Price, S Lim, B Paterson, J Hickey, T Rhoads, J Williams, K Kanninen, L Hung, J Liddell, A Grubman, J Monty, R Llanos, D Kramer, J Mercer, A Bush, C Masters, J Duce, Q Li, J Beckman, K Barnham, A White, P Crouch

(2014), Vol. 34, pp. 8021-8031, Journal of neuroscience, Washington, D.C., C1

journal article
2013

Gene expression profiling of rotenone-mediated cortical neuronal death: Evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling

Y Yap, M Chen, Z Peng, J Manikandan, J Ng, R Llanos, S La Fontaine, P Beart, N Cheung

(2013), Vol. 62, pp. 653-663, Neurochemistry International, C1

journal article

Gene profiling identifies commonalities in neuronal pathways in excitotoxicity: Evidence favouring cell cycle re-activation in concert with oxidative stress

M Chen, J Ng, Z Peng, J Manikandan, Y Yap, R Llanos, P Beart, N Cheung

(2013), Vol. 62, pp. 719-730, Neurochemistry International, C1

journal article

Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase

V Sudhahar, N Urao, J Oshikawa, R McKinney, R Llanos, J Mercer, M Ushio-Fukai, T Fukai

(2013), Vol. 62, pp. 3839-3850, Diabetes, Alexandria, Va., C1-1

journal article
2010

Missense Mutations in the Copper Transporter Gene ATP7A Cause X-Linked Distal Hereditary Motor Neuropathy

M Kennerson, G Nicholson, S Kaler, B Kowalski, J Mercer, J Tang, R Llanos, S Chu, R Takata, C Speck-Martins, J Baets, L Almeida-Souza, D Fischer, V Timmerman, P Taylor, S Scherer, T Ferguson, T Bird, P De Jonghe, S Feely, M Shy, J Garbern

(2010), Vol. 86, pp. 343-352, American Journal of Human Genetics, C1-1

journal article
2008

Copper transport during lactation in transgenic mice expressing the human ATP7A protein

R Llanos, A Michalczyk, D Freestone, S Currie, M Linder, M Ackland, J Mercer

(2008), Vol. 372, pp. 613-617, Biochemical and Biophysical Research Communications, C1

journal article

ATP7A transgenic and nontransgenic mice are resistant to high copper exposure

B Ke, R Llanos, J Mercer

(2008), Vol. 138, pp. 693-697, Journal of nutrition, Bethesda, Md., C1-1

journal article
2006

Correction of a mouse model of Menkes disease by the human Menkes gene

R Llanos, B Ke, M Wright, Y Deal, F Monty, D Kramer, J Mercer

(2006), Vol. 1762, pp. 485-493, Biochimica et Biophysica Acta - Molecular Basis of Disease, C1

journal article

Alteration of copper physiology in mice overexpressing the human Menkes protein ATP7A

B Ke, R Llanos, M Wright, Y Deal, J Mercer

(2006), Vol. 290, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, C1

journal article
2005

Copper exposure induces trafficking of the Menkes protein in intestinal epithelium of ATP7A transgenic mice

J Monty, R Llanos, J Mercer, D Kramer

(2005), Vol. 135, pp. 2762-2766, Journal of Nutrition, C1

journal article
2003

Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

D Kramer, R Llanos, J Mercer

(2003), pp. 207-244, Metal ions and neurodegenerative disorders, Singapore, B1

book chapter

Molecular and cellular aspects of copper transport in developing mammals

J Mercer, R Llanos

(2003), Vol. 133, Journal of Nutrition, C1

journal article

Copper-induced trafficking of the Cu-ATPases: A key mechanism for copper homeostasis

J Mercer, N Barnes, J Stevenson, D Strausak, R Llanos

(2003), Vol. 16, pp. 175-184, BIOMETALS, C1

journal article
2002

The molecular basis of copper homeostasis and copper-related disorders

R Llanos, J Mercer

(2002), Vol. 21, pp. 259-270, DNA and Cell Biology, C1

journal article

Copper-regulated trafficking of the Menkes disease copper ATPase associated with formation of a phosphorylated catalytic intermediate

M Petris, I Voskoboinik, M Cater, K Smith, B Kim, R Llanos, D Strausak, J Camakaris, J Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Baltimore, Md., C1

journal article

Copper-regulated trafficking of the Menkes disease copper ATPases is associated with the formation of a phosphorylated intermediate

M Petris, I Vokoboinik, M Cater, K Smith, B Kim, R Llanos, D Strausak, J Camakaris, J Mercer

(2002), Vol. 277, pp. 46736-46742, Journal of biological chemistry, Bethesda, Md., C1-1

journal article

Funded Projects at Deakin

Other Funding Sources

Travel Grant -The Ian Potter Foundation

Dr Roxana Llanos

  • 2006: $2,000

Supervisions

Associate Supervisor
2006

Alanna Castelli

Thesis entitled: Mutation Analysis of the Menkes Gene

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences

2003

Natalie Barnes

Thesis entitled: Structure Function Studies of Mammalian Copper ATPases

Doctor of Philosophy (Biol & Chem), School of Life and Environmental Sciences