Dr Sarah Shigdar

STAFF PROFILE

Position

Senior Lecturer in Medical Science

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy, Deakin University, 2009
Bachelor of Science (Biological Science), University of Wolverhampton, 1995

Contact

sarah.shigdar@deakin.edu.au
+61 3 522 72846

Research interests

Dr Shigdar is focused on the development of aptamers, also known as chemical antibodies, for their use in both diagnostic and therapeutic applications. Dr Shigdar's main focus is on the use of aptamers for the treatment of neurological disorders - brain cancers, brain metastases, and neurodegenerative disorders

Units taught

HMM101 Introduction to Medical Biotechnology

Knowledge areas

Aptamers

Professional activities

President International Society of Aptamers 2016 -

Awards

Smart Geelong Awards - Researcher of the Year 2011 – Population Health and Lifestyle - 'Establishing a Platform for the Generation of RNA Missiles Targeting Cancer Initiating Cells'

Smart Geelong Awards - Early Career Researcher of the Year 2013 - 'Getting the brain to take its medicine – development of a smart platform to treat tumour metastases'

Projects

Aptamers as theranostic agents

Getting the brain to take its medicine

Publications

Filter by

2020

Bifunctional aptamer-doxorubicin conjugate crosses the blood-brain barrier and selectively delivers Its payload to EpCAM-positive tumor cells

J Macdonald, D Denoyer, J Henri, A Jamieson, I Burvenich, N Pouliot, S Shigdar

(2020), Vol. 30, pp. 117-128, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal article

Antibodies, nanobodies, or aptamers-which is best for deciphering the proteomes of non-model species?

P Dhar, R Samarasinghe, S Shigdar

(2020), Vol. 21, pp. 1-14, International journal of molecular sciences, Basel, Switzerland, C1

journal article
2019

Radiolabelled aptamers for theranostic treatment of cancer

Umair Khalid, Chris Vi, Justin Henri, Joanna Macdonald, Peter Eu, Giovanni Mandarano, Sarah Shigdar

(2019), Vol. 12, Pharmaceuticals, Basel, Switzerland, C1

journal article

Anything you can do, I can do better: can aptamers replace antibodies in clinical diagnostic applications?

michelle Bauer, mia Strom, david Hammond, Sarah Shigdar

(2019), Vol. 24, pp. 1-13, Molecules, Basel, Swtizerland, C1

journal article
2018

Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis

X She, L Chen, Z Yi, C Li, C He, C Feng, T Wang, S Shigdar, W Duan, L Kong

(2018), Vol. 16, pp. 976-989, Mini-reviews in medicinal chemistry, Beijing, China, C1

journal article

Aptamers as potential therapeutic agents for ovarian cancer

J Henri, J Macdonald, M Strom, W Duan, S Shigdar

(2018), Vol. 145, pp. 34-44, Biochimie, Amsterdam, The Netherlands, C1

journal article

EpCAM immunotherapy versus specific targeted delivery of drugs

Joanna Macdonald, Justin Henri, Kislay Roy, Emma Hays, Michelle Bauer, Rakesh Veedu, Normand Pouliot, Sarah Shigdar

(2018), Vol. 10, pp. 1-13, Cancers, Basel, Switzerland, C1

journal article

Mesoporous silica nanorods toward efficient loading and intracellular delivery of siRNA

L Chen, X She, T Wang, S Shigdar, W Duan, L Kong

(2018), Vol. 20, pp. 1-13, Journal of nanoparticle research, Cham, Switzerland, C1

journal article

Development of transferrin receptor aptamers as drug delivery vehicles for the treatment of brain metastases

Joanna Macdonald, G Mandarano, Rakesh Veedu, Sarah Shigdar

(2018), Vol. 2, pp. 15-27, Aptamers, Oxford, Eng., C1

journal article

RNA aptamers-guided precision cancer medicine

W Duan, T Wang, S Shigdar, P Tran

(2018), Vol. 63, pp. 529-535, BME6 2016 : 6th International Conference on the Development of Biomedical Engineering in Vietnam, Ho Chi Minh City, Vietnam, E1

conference
2017

Challenges and opportunities for siRNA-based cancer treatment

T Wang, S Shigdar, H Al Shamaileh, M Gantier, W Yin, D Xiang, L Wang, S-F Zhou, Y Hou, P Wang, W Zhang, C Pu, W Duan

(2017), Vol. 387, pp. 77-83, Cancer letters, Shannon, Ireland, C1

journal article

Development of a bifunctional aptamer targeting the transferrin receptor and epithelial cell adhesion molecule (EpCAM) for the treatment of brain cancer metastases

J Macdonald, J Henri, L Goodman, D Xiang, W Duan, S Shigdar

(2017), Vol. 8, pp. 777-784, ACS chemical neuroscience, Washington, D.C., C1

journal article

Aptamer-mediated survivin RNAi enables 5-fluorouracil to eliminate colorectal cancer stem cells

H Al Shamaileh, T Wang, D Xiang, W Yin, P Tran, R Barrero, P-Z Zhang, Y Li, L Kong, K Liu, S-F Zhou, Y Hou, S Shigdar, W Duan

(2017), Vol. 7, pp. 1-9, Scientific reports, London, Eng., C1

journal article

Transforming doxorubicin into a cancer stem cell killer via EpCAM aptamer-mediated delivery

D Xiang, S Shigdar, A Bean, M Bruce, W Yang, M Mathesh, T Wang, W Yin, P Tran, H Shamaileh, R Barrero, P Zhang, Y Li, L Kong, K Liu, S Zhou, Y Hou, A He, W Duan

(2017), Vol. 7, pp. 4071-4086, Theranostics, Sydney, N.S.W., C1

journal article

Aptamers and glioblastoma: their potential use for imaging and therapeutic applications

E Hays, W Duan, S Shigdar

(2017), Vol. 18, pp. 1-17, International journal of molecular sciences, Basel, Switzerland, C1

journal article

Development of cell-specific aptamers: recent advances and insight into the selection procedures

K Rahimizadeh, H AlShamaileh, M Fratini, M Chakravarthy, M Stephen, S Shigdar, R Veedu

(2017), Vol. 22, Molecules, Basel, Switzerland, C1

journal article
2016

Application of aptamers in histopathology

S Shigdar, L Lv, L Wang, W Duan

(2016), Vol. 1380, pp. 191-196, Nucleic acid aptamers : selection, characterization and application, New York, N.Y., B1

book chapter

The Application of aptamers for immunohistochemistry

M Bauer, J Macdonald, J Henri, W Duan, S Shigdar

(2016), Vol. 26, pp. 120-126, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal article

Truncation and mutation of a transferrin receptor aptamer enhance binding affinity

J Macdonald, P Houghton, D Xiang, W Duan, S Shigdar

(2016), Vol. 26, pp. 348-354, Nucleic acid therapeutics, New Rochelle, N.Y., C1

journal article
2015

Cytokine networks and cancer stem cells

C Liongue, A Ward, W Duan, S Shigdar

(2015), pp. 67-87, Cancer stem cells : emerging concepts and future perspectives in translational oncology, Berlin, Germany, B1

book chapter

Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine

D Xiang, S Shigdar, G Qiao, T Wang, A Kouzani, S Zhou, L Kong, Y Li, C Pu, W Duan

(2015), Vol. 5, pp. 23-42, Theranostics, Wyoming, N.S.W., C1

journal article

Aptamer-mediated cancer gene therapy.

D Xiang, S Shigdar, G Qiao, S Zhou, Y Li, M Wei, L Qiao, H Shamaileh, Y Zhu, C Zheng, C Pu, W Duan

(2015), Vol. 15, pp. 109-119, Current Gene Therapy, Bussum, Netherlands, C1

journal article

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery.

X She, L Chen, L Velleman, C Li, H Zhu, C He, T Wang, S Shigdar, W Duan, L Kong

(2015), Vol. 445, pp. 151-160, Journal of Colloid and Interface Science, United States, C1

journal article

The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery

X She, L Chen, L Velleman, C Li, C He, J Denman, T Wang, S Shigdar, W Duan, L Kong

(2015), Vol. 3, pp. 6094-6104, Journal of materials chemistry B, Cambridge, Eng., C1

journal article

Superior performance of aptamer in tumor penetration over antibody : implication of aptamer-based theranostics in solid tumors

D Xiang, C Zheng, S Zhou, S Qiao, P Tran, C Pu, Y Li, L Kong, A Kouzani, J Lin, K Liu, L Li, S Shigdar, W Duan

(2015), Vol. 5, pp. 1083-1097, Theranostics, Sydney, N.S.W., C1

journal article

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

L Chen, X She, T Wang, L He, S Shigdar, W Duan, L Kong

(2015), Vol. 7, pp. 14080-14092, Nanoscale, Cambridge, Eng., C1

journal article

Cancer stem cell targeted therapy: progress amid controversies

T Wang, S Shigdar, M Gantier,, Y Hou,, L Wang,, Y Li,, H Shamaileh,, W Yin, S Zhou,, X Zhao,, W Duan

(2015), Vol. 6, pp. 44191-44206, Oncotarget, Albany, N.Y., C1

journal article

EpCAM aptamer-mediated survivin silencing sensitized cancer stem cells to doxorubicin in a breast cancer model

T Wang, M Gantier, D Xiang, A Bean, M Bruce, S Zhou, M Khasraw, A Ward, L Wang, M Wei, H AlShamaileh, L Chen, X She, J Lin, L Kong, S Shigdar, W Duan

(2015), Vol. 5, pp. 1456-1472, Theranostics, Wyoming, N.S.W., C1

journal article
2014

Inflammation and cancer stem cells

S Shigdar, Y Li, S Bhattacharya, M O'Connor, C Pu, J Lin, T Wang, D Xiang, L Kong, M Wei, Y Zhu, S Zhou, W Duan

(2014), Vol. 345, pp. 271-278, Cancer Letters, C1

journal article

Improved efficacy and reduced toxicity of doxorubicin encapsulated in sulfatide-containing nanoliposome in a glioma model

J Lin, S Shigdar, D Fang, D Xiang, M Wei, A Danks, L Kong, L Li, L Qiao, W Duan

(2014), Vol. 9, pp. 1-13, Plos One, San Francisco, CA, C1

journal article

Cancer stem cells: a contentious hypothesis now moving forward

M O'Connor, D Xiang, S Shigdar, J Macdonald, Y Li, T Wang, C Pu, Z Wang, L Qiao, W Duan

(2014), Vol. 344, pp. 180-187, Cancer letters, Shannon, Ireland, C1

journal article

CD44 variant 6 is associated with prostate cancer metastasis and chemo-/radioresistance

J Ni, P Cozzi, J Hao, J Beretov, L Chang, W Duan, S Shigdar, W Delprado, P Graham, J Bucci, J Kearsley, Y Li

(2014), Vol. 74, pp. 602-617, Prostate, Hoboken, NJ, C1

journal article

Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells

L Li, D Xiang, S Shigdar, W Yang, Q Li, J Lin, K Liu, W Duan

(2014), Vol. 9, pp. 1083-1096, International journal of nanomedicine, Macclesfield, England, C1

journal article
2013

RNA aptamers targeting cancer stem cell marker CD133

S Shigdar, L Qiao, S Zhou, D Xiang, T Wang, Y Li, L Lim, L Kong, L Li, W Duan

(2013), Vol. 330, pp. 84-95, Cancer Letters, C1

journal article

The use of sensitive chemical antibodies for diagnosis: detection of low levels of Epcam in breast cancer

S Shigdar, C Qian, L Lv, C Pu, Y Li, L Li, M Marappan, J Lin, L Wang, W Duan

(2013), Vol. 8, pp. 1-8, PLoS One, San Diego, United States, C1

journal article

Epithelial cell adhesion molecule (EpCAM) is associated with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway

J Ni, P Cozzi, J Hao, J Beretov, L Chang, W Duan, S Shigdar, W Delprado, P Graham, J Bucci, J Kearsley, Y Li

(2013), Vol. 45, pp. 2736-2748, International Journal of Biochemistry and Cell Biology, C1

journal article

Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo

D Xiang, D Xiang, Z Yang, Z Yang, W Duan, W Duan, X Li, X Li, J Yin, J Yin, S Shigdar, S Shigdar, M O'Connor, M O'Connor, M Marappan, M Marappan, X Zhao, X Zhao, Y Miao, Y Miao, B Xiang, B Xiang, C Zheng, C Zheng

(2013), Vol. 8, pp. 4103-4114, International Journal of Nanomedicine, Macclesfield, UK, C1

journal article

Aptamers as theranostic agents: modifications, serum stability and functionalisation

S Shigdar, J Macdonald, M O'Connor, T Wang, D Xiang, H Al.Shamaileh, L Qiao, M Wei, S Zhou, Y Zhu, L Kong, S Bhattacharya, C Li, W Duan

(2013), Vol. 13, pp. 13624-13637, Sensors, Basel, Switzerland, C1

journal article
2012

Aptamers and nanomedicine

S Shigdar, A Smith, W Duan

(2012), pp. 275-296, Nanotechnology in Health Care, B1-1

book chapter

Cancer stem cell targeting: The next generation of cancer therapy and molecular imaging

S Shigdar, J Lin, Y Li, C Yang, M Wei, Y Zhu, H Liu, W Duan

(2012), Vol. 3, pp. 227-244, Therapeutic Delivery, C1

journal article

Enhanced Antitumor Efficacy and Reduced Systemic Toxicity of Sulfatide-Containing Nanoliposomal Doxorubicin in a Xenograft Model of Colorectal Cancer

J Lin, Y Yu, S Shigdar, D Fang, J Du, M Wei, A Danks, K Liu, W Duan

(2012), Vol. 7, PLoS ONE, C1-1

journal article

Role of the EpCAM (CD326) in prostate cancer metastasis and progression

J Ni, P Cozzi, W Duan, S Shigdar, P Graham, K John, Y Li

(2012), Vol. 31, pp. 779-791, Cancer and Metastasis Reviews, C1

journal article
2011

Groundwater pre-treatment prevents the onset of chronic ulcerative dermatopathy in juvenile Murray cod, Maccullochella peelii peelii (Mitchell)

A Schultz, S Shigdar, P Jones, A Ward, T Toop

(2011), Vol. 312, pp. 19-25, Aquaculture, C1

journal article

Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults

J Lin, D Fang, J Du, S Shigdar, L Xiao, X Zhou, W Duan

(2011), Vol. 58, pp. 150-157, Annals of Nutrition and Metabolism, C1

journal article

Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies

S Shigdar, A Ward, A De, C Yang, M Wei, W Duan

(2011), Vol. 155, pp. 3-13, British Journal of Haematology, C1

journal article

RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

S Shigdar, J Lin, Y Yu, M Pastuovic, M Wei, W Duan

(2011), Vol. 102, pp. 991-998, Cancer Science, C1-1

journal article
2010

Aptamer Therapeutics: The 21st Century`s Magic Bullet of Nanomedicine

Sarah Shigdar, Jasmina Luczo, Ming Wei, Richard Bell, Andrew Danks, Ke Liu, Wei Duan

(2010), Vol. 1, pp. 118-124, The Open Conference Proceedings Journal, C1-1

journal article

TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults

J Du, D Fang, J Lin, L Xiao, X Zhou, S Shigdar, W Duan

(2010), Vol. 21, pp. 1114-1119, Journal of nutritional biochemistry, New York, N.Y., C1-1

journal article
2009

Cytochemical characterisation of the leucocytes and thrombocytes from Murray cod (Maccullochella peelii peelii, Mitchell)

S Shigdar, A Harford, A Ward

(2009), Vol. 26, pp. 731-736, Fish and Shellfish Immunology, C1

journal article
2008

Functional interaction between mutations in the granulocyte colony-stimulating factor receptor in severe congenital neutropenia

A Ward, J Gits, F Majeed, A Aprikyan, R Lewis, L O'Sullivan, M Freedman, S Shigdar, I Touw, D Dale, Y Dror

(2008), Vol. 142, pp. 653-656, British Journal of Haematology, C1

journal article
2007

Blood cells of murray cod Maccullochella peelii peelii (Mitchell)

S Shigdar, D Cook, P Jones, A Harford, A Ward

(2007), Vol. 70, pp. 973-980, Journal of Fish Biology, C1

journal article
2003

The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion

P Dodson, J Haynes, J Starczynski, J Farmer, S Shigdar, G Fegan, R Johnson, C Fegan

(2003), Vol. 17, pp. 772-777, Eye, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

A novel approach to target beta-cells to enhance survival and function

Dr Kathryn Aston-Mourney, Dr Sarah Shigdar, Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2020: $59,756

Other Public Sector Funding

Targeting site specific improvements of clinical trial operational processes.

Dr Sarah Shigdar, Mr Justin Liam Henri

  • 2020: $42,369

Industry and Other Funding

Improving Cancer Diagnostics By Using Chemical Flags - Cancer Research Scholarship

Prof Alister Ward, Dr Sarah Shigdar

  • 2017: $14,000
  • 2016: $14,000
  • 2015: $14,000

Getting the brain to take its medicine

Dr Sarah Shigdar, Dr Normand Pouliot, Dr Mustafa Khasraw

  • 2018: $59,000

Saving our antibiotics: an innovative way of restoring bacterial sensitivity to antimicrobials

Dr Ben Wade, A/Prof Tamsyn Crowley, Dr Sarah Shigdar, Dr Anthony Keyburn

  • 2018: $41,000

Targeting site specific improvements of clinical trial operational processes.

Dr Sarah Shigdar, Mr Justin Liam Henri

  • 2020: $1,573

Supervisions

Principal Supervisor
2017

Joanna Michelle Macdonald

Thesis entitled: A bifunctional aptamer for the targeted treatment of brain metastases

Doctor of Philosophy (Medicine), School of Medicine

2015

Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2019

Shauna Seneviratne

Thesis entitled: The effects of Ficolin and the Fibrinogen-like domain on ex vivo hematopoietic stem cell expansion.

Doctor of Philosophy (Biol & Chem), Institute for Frontier Materials

2018

Wang Yin

Thesis entitled: Novel strategies to overcome drug resistance in liver cancer

Doctor of Philosophy (Medicine), School of Medicine

2016

Hadi Al Shamaileh

Thesis entitled: Aptamer-mediated siRNA delivery to target colon cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine

Lijue Chen

Thesis entitled: Delivery of Fluorouracil and siRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer

Doctor of Philosophy (Engineering), Institute for Frontier Materials

2015

Dongxi Xiang

Thesis entitled: Developing RNA aptamer technology for targeting cancer stem cells

Doctor of Philosophy (Medicine), School of Medicine

2014

Tao Wang

Thesis entitled: An aptamer-mediated siRNA delivery system targeting breast tumourigenic cells

Doctor of Philosophy (Medicine), School of Medicine

Manju Marappan

Thesis entitled: Efficacy of utilizing chemical antibodies in histopathological studies

MAppSc (Medicine) (High cost), School of Medicine