A/Prof. Sean Mcgee



Associate Professor of Medical Biology


Faculty of Health


School of Medicine


Geelong Waurn Ponds Campus


Graduate Certificate of Higher Education, Deakin University, 2011
Doctor of Philosophy, Deakin University, 2005
Bachelor of Applied Science, Deakin University, 2002


+61 3 522 72519


Associate Professor McGee obtained his PhD in Molecular Physiology from Deakin University in 2005 and completed postdoctoral training at the Department of Physiology, The University of Melbourne, and The Welcome Trust Biocentre, University of Dundee, Scotland. At the beginning of 2009, relocated his research program to the School of Medicine, Deakin University, where he currently heads the Metabolic Reprogramming Laboratory, within the Metabolic Research Unit.

Read more on Sean's profile

Research interests

Chronic over-nutrition is driving an epidemic of chronic diseases that includes obesity and type 2 diabetes, cardiovascular disease and cancer. Cellular metabolic reprogramming underpins the pathogenesis of all of these diseases. Our laboratory aims to understand the mechanisms that mediate metabolic reprogramming in these diseases and seeks to leverage this knowledge to develop therapies to combat the chronic disease epidemic.


Member of the Australian Diabetes Society, the Australian Physiological Society and the Australian Society for Biochemistry and Molecular Biology.

Teaching interests

Associate Professor McGee is coordinator of the Medical Sciences Metabolism and Musculoskeletal block (HME921) within the Doctor of Medicine degree and also supervisors honours and PhD students.

Knowledge areas

Metabolism, cell signalling, transcription, obesity and type 2 diabetes, cancer metabolism, cardiac metabolism

Professional activities

Diabetes Australia Research Advisory Panel - 2019 to present

National Breast Cancer Foundation Peer Review Committee - 2017

Editorial Board Member, Translational Sport Medicine - 2017 to present

Review Editor in Obesity, Frontiers in Endocrinology - 2016 to present

NHMRC Grant Review Panel Member -  2012, 2013, 2015

Treasurer, Metabolism and Molecular Medicine Special Interest Group, The Australian Society for Biochemistry and Molecular Biology - 2014 to present


Associate Professor McGee has been awarded research funds totalling in excess of $5 million, with the majority from external National Competitive Grant Schemes, such as the National Health and Medical Research Council (NHMRC), the Diabetes Australia Research Trust (DART) and the National Breast Cancer Foundation. Dr McGee has also been awarded prestigious fellowships, including an NHMRC Peter Doherty Fellowship, the DART Viertel Fellowship and an NHMRC Career Development Fellowship. He was also awarded the AK McIntrye Medal from the Australian Physiological Society in 2010.



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A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes

Amanda Genders, Sheree Martin, Sean McGee, David Bishop

(2019), Vol. 316, pp. C404-C414, American journal of physiology: cell physiology, Bethesda, Md., C1


Adhesive capsulitis of the shoulder: protocol for the adhesive capsulitis biomarker (AdCaB) study

Richard Page, Sean McGee, Kevin Eng, Graeme Brown, Sally Beattie, Fiona Collier, Stephen Gill

(2019), Vol. 20, BMC musculoskeletal disorders, London, Eng., C1


Genetic and epigenetic sex-specific adaptations to endurance exercise

Shanie Landen, Sarah Voisin, Jeffrey Craig, Sean McGee, Sverine Lamon, Nir Eynon

(2019), Vol. 14, pp. 523-535, Epigenetics, Abingdon, Eng., C1


Class IIa HDACs do not influence beta-cell function under normal or high glucose conditions

Jacob McCann, Megan Ellis, Sean McGee, Kathryn Aston-Mourney

(2019), Vol. 11, pp. 112-118, Islets, Abingdon, Eng., C1


Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass

A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce

(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1


Epigenetics and exercise

S McGee, M Hargreaves

(2019), Vol. 30, pp. 636-645, Trends in endocrinology and metabolism, Amsterdam, The Netherlands, C1


Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

K Hasebe, L Rivera, C Smith, T Allnutt, T Crowley, T Nelson, O Dean, S McGee, K Walder, L Gray

(2019), Vol. 82, pp. 309-318, Brain, behavior, and immunity, Amsterdam, The Netherlands, C1


Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

J Wali, S Galic, C Tan, E Gurzov, A Frazier, T Connor, J Ge, E Pappas, D Stroud, L Varanasi, C Selck, M Ryan, D Thorburn, B Kemp, B Krishnamurthy, T Kay, S McGee, H Thomas

(2018), Vol. 25, pp. 217-225, Cell death and differentiation, London, Eng., C1


Mechanisms underpinning the polypharmacy effects of medications in psychiatry

Chiara Bortolasci, Briana Spolding, Edward Callaly, Sheree Martin, Bruna Panizzutti, Srisaiyini Kidnapillai, Timothy Connor, Kyoko Hasebe, Mohammadreza Mohebbi, Olivia Dean, Sean McGee, Seetal Dodd, Laura Gray, Michael Berk, Ken Walder

(2018), Vol. 21, pp. 582-591, The international journal of neuropsychopharmacology, Oxford, Eng., C1


Metabolic reprogramming in type 2 diabetes and the development of breast cancer

Sheree Martin, Sean McGee

(2018), Vol. 237, pp. R35-R46, Journal of Endocrinology, Bradley Stok, Eng., C1


Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression

J Price, Carrie Bronars, Sophie Erhardt, Kathyrn Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean McGee, Mark Frye, Susannah Tye

(2018), Vol. 90, pp. 212-220, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1


APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

J Czeczor, A Genders, K Aston-Mourney, T Connor, L Hall, K Hasebe, M Ellis, K De Jong, D Henstridge, P Meikle, M Febbraio, K Walder, S McGee

(2018), Vol. 237, pp. 311-322, Journal of endocrinology, Bradley Stok, Eng., C1


Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring

K De Jong, S Barrand, R Wood-Bradley, D de Almeida, J Czeczor, G Lopaschuk, J Armitage, S McGee

(2018), Vol. 28, pp. 600-609, Nutrition, metabolism and cardiovascular diseases, Amsterdam, The Netherlands, C1


Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

H Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill Chang, Anson Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin Gasser

(2018), Vol. 8, pp. 379-385, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1


Exercise and GLUT4 in human subcutaneous adipose tissue

Marcelo Flores-Opazo, Eva Boland, Andrew Garnham, Robyn Murphy, Sean McGee, Mark Hargreaves

(2018), Vol. 6, pp. 1-8, Physiological reports, Chichester, Eng., C1


Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

H Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill Chang, Anson Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin Gasser

(2018), Vol. 8, pp. 379-385, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1


A model of the mitochondrial basis of bipolar disorder

G Morris, K Walder, S McGee, O Dean, S Tye, M Maes, M Berk

(2017), Vol. 74, pp. 1-20, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1


Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

V Gaur, T Connor, K Venardos, D Henstridge, S Martin, C Swinton, S Morrison, K Aston-Mourney, S Gehrig, R van Ewijk, G Lynch, M Febbraio, G Steinberg, M Hargreaves, K Walder, S McGee

(2017), Vol. 19, pp. 936-943, Diabetes, obesity and metabolism, Chichester, Eng., C1


Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study

K De Jong, J Czeczor, S Sithara, K McEwen, G Lopaschuk, A Appelbe, K Cukier, M Kotowicz, S McGee

(2017), Vol. 16, pp. 1-12, Cardiovascular diabetology, London, Eng., C1


Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1


Exercise and the skeletal muscle epigenome

S McGee, K Walder

(2017), Vol. 7, Cold Spring Harbor Perspectives in Medicine, Cold Spring Harbor, N.Y., C1


Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism

J Czeczor, S McGee

(2017), Vol. 29, pp. 1-8, Journal of neuroendocrinology, London, Eng., C1


Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S Preston, P Korhonen, L Mouchiroud, M Cornaglia, S McGee, N Young, R Davis, S Crawford, C Nowell, B Ansell, G Fisher, K Andrews, B Chang, M Gijs, P Sternberg, J Auwerx, J Baell, A Hofmann, A Jabbar, R Gasser

(2017), Vol. 31, pp. 4515-4532, The FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, Bethesda, Md., C1


Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

M Coughlan, G Higgins, T-V Nguyen, S Penfold, V Thallas-Bonke, S Tan, G Ramm, N Van Bergen, D Henstridge, K Sourris, B Harcourt, I Trounce, P Robb, A Laskowski, S McGee, A Genders, K Walder, B Drew, P Gregorevic, H Qian, M Thomas, G Jerums, R Macisaac, A Skene, D Power, E Ekinci, X Wijeyeratne, L Gallo, M Herman-Edelstein, M Ryan, M Cooper, D Thorburn, J Forbes

(2016), Vol. 65, pp. 1085-1098, Diabetes, Alexandria, Va., C1


A syntenic cross species aneuploidy genetic screen links RCAN1 expression to ?-cell mitochondrial dysfunction in Type 2 diabetes

H Peiris, M Duffield, J Fadista, C Jessup, V Kashmir, A Genders, S McGee, A Martin, M Saiedi, N Morton, R Carter, M Cousin, A Kokotos, N Oskolkov, P Volkov, T Hough, E Fisher, V Tybulewicz, J Busciglio, P Coskun, A Becker, P Belichenko, W Mobley, M Ryan, J Chan, D Laybutt, P Coates, S Yang, C Ling, L Groop, M Pritchard, D Keating

(2016), Vol. 12, pp. 1-24, PLoS genetics, San Francisco, Calif., C1


Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

Y Kim, S McGee, J Czeczor, A Walker, R Kale, A Kouzani, K Walder, M Berk, S Tye

(2016), Vol. 6, pp. 1-7, Translational psychiatry, London, Eng., C1


Epigenetic regulation of skeletal muscle metabolism

K Howlett, S McGee

(2016), Vol. 130, pp. 1051-1063, Clinical science, London, Eng., C1


Screening of the 'pathogen box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

S Preston, Y Jiao, A Jabbar, S McGee, B Laleu, P Willis, T Wells, R Gasser

(2016), Vol. 6, pp. 329-334, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1


?-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Mller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschp, M Watt, I Clarke, C Roth, K Grove, M Cowley

(2016), Vol. 5, pp. 807-822, Molecular metabolism, Amsterdam, The Netherlands, C1


Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell reports, New York, N.Y., C1


Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

T Connor, S Martin, K Howlett, S McGee

(2015), Vol. 42, pp. 109-115, Clinical and Experimental Pharmacology and Physiology, England, London, C1


N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

D Wright, T Renoir, Z Smith, A Frazier, P Francis, D Thorburn, S McGee, A Hannan, L Gray

(2015), Vol. 5, pp. 1-10, Translational psychiatry, New York, N. Y., C1


Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.

C Wilson, S Shalini, A Filipovska, T Richman, S Davies, S Martin, S McGee, J Puccini, A Nikolic, L Dorstyn, S Kumar

(2015), Vol. 6, pp. e1597-e1597, Cell Death and Disease, England, C1


The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice

K Venardos, K De Jong, M Elkamie, T Connor, S McGee

(2015), Vol. 10, pp. 1-14, PLoS one, San Francisco, Calif., C1-1


ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1


The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1


Lipid abundance in zebrafish embryos is regulated by complementary actions of the endocannabinoid system and retinoic acid pathway

D Fraher, M Ellis, S Morrison, S McGee, A Ward, K Walder, Y Gibert

(2015), Vol. 156, pp. 3596-3609, Endocrinology, Bethesda, Md., C1


3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages

S Morrison, S McGee

(2015), Vol. 4, pp. 295-302, Adipocyte, London, Eng., C1


Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio

(2014), Vol. 63, pp. 1881-1894, Diabetes, C1


Improved synthesis and structural reassignment of MC1568: A class IIa selective HDAC inhibitor

C Fleming, T Ashton, V Gaur, S McGee, F Pfeffer

(2014), Vol. 57, pp. 1132-1135, Journal of Medicinal Chemistry, C1


Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

S Martin, S Morrison, N Konstantopoulos, S McGee

(2014), Vol. 3, pp. 408-418, Molecular metabolism, Amsterdam, Netherlands, C1


Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury

D Williams, K Venardos, M Byrne, M Joshi, D Horlock, N Lam, P Gregorevic, S McGee, D Kaye

(2014), Vol. 9, pp. 1-11, PLoS one, San Francisco, CA, C1


Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

T Parmenter, M Kleinschmidt, K Kinross, S Bond, J Li, M Kaadige, A Rao, K Sheppard, W Hugo, G Pupo, R Pearson, S McGee, G Long, R Scolyer, H Rizos, R Lo, C Cullinane, D Ayer, A Ribas, R Johnstone, R Hicks, G McArthur

(2014), Vol. 4, pp. 423-433, Cancer Discovery, Philadelphia, PA, C1


Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

S McGee, C Swinton, S Morrison, V Gaur, D Campbell, S Jorgensen, B Kemp, K Baar, G Steinberg, M Hargreaves

(2014), Vol. 28, pp. 3384-3395, FASEB journal, Bethesda, MD, C1


The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

S Martin, S McGee

(2014), Vol. 1840, pp. 1303-1312, Biochimica et biophysica acta, Amsterdam, The Netherlands, C1


Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals

K Vissing, S Mcgee, J Farup, T Kjlhede, M Vendelbo, N Jessen

(2013), Vol. 23, pp. 355-366, Scandinavian Journal of Medicine and Science in Sports, C1


Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

A Walker, S Burnett, K Hasebe, J McGillivray, L Gray, S McGee, K Walder, M Berk, S Tye

(2013), Vol. 242, pp. 76-83, Behavioural Brain Research, C1


Effect of DHA and CoenzymeQ10 against A?- and zinc-induced mitochondrial dysfunction in human neuronal cells

N Sadli, C Barrow, S McGee, C Suphioglu

(2013), Vol. 32, pp. 243-252, Cellular Physiology and Biochemistry, C1


Metabolic profile analysis of zebrafish embryos

Y Gibert, S McGee, A Ward

(2013), Vol. 71, pp. 1-5, Journal of visualized experiments, Cambridge, Mass., C1


Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism

S Richter, S Morrison, T Connor, J Su, C Print, R Ronimus, S McGee, W Wilson

(2013), Vol. 8, PLoS ONE, C1


The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

C Winbanks, J Chen, H Qian, Y Liu, B Bernardo, C Beyer, K Watt, R Thomson, T Connor, B Turner, J McMullen, L Larsson, S McGee, C Harrison, P Gregorevic

(2013), Vol. 203, pp. 345-357, Journal of Cell Biology, C1


Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

W Sanchez, S McGee, T Connor, B Mottram, A Wilkinson, J Whitehead, S Vuckovic, L Catley

(2013), Vol. 108, pp. 1624-1633, British Journal of Cancer, C1


Skeletal muscle fat metabolism after exercise in humans: Influence of fat availability

N Kimber, D Cameron-Smith, S McGee, M Hargreaves

(2013), Vol. 114, pp. 1577-1585, Journal of Applied Physiology, C1


Caveolin-1 is necessary for hepatic oxidative lipid metabolism: Evidence for crosstalk between caveolin-1 and bile acid signaling

M Fernndez-Rojo, M Gongora, R Fitzsimmons, N Martel, S Martin, S Nixon, A Brooks, M Ikonomopoulou, S Martin, H Lo, S Myers, C Restall, C Ferguson, P Pilch, S McGee, R Anderson, M Waters, J Hancock, S Grimmond, G Muscat, R Parton

(2013), Vol. 4, pp. 238-247, Cell Reports, C1


Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo

N Konstantopoulos, J Molero, S McGee, B Spolding, T Connor, M De Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, V Foletta, G Krippner, S Andrikopoulos, K Walder

(2012), Vol. 61, pp. 2146-2154, Diabetes, C1


Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

S Raichur, S Teh, K Ohwaki, V Gaur, Y Long, M Hargreaves, S McGee, J Kusunoki

(2012), Vol. 49, pp. 203-211, Journal of Molecular Endocrinology, C1


Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat

R Teperino, S Amann, M Bayer, S McGee, A Loipetzberger, T Connor, C Jaeger, B Kammerer, L Winter, G Wiche, K Dalgaard, M Selvaraj, M Gaster, R Lee-Young, M Febbraio, C Knauf, P Cani, F Aberger, J Penniger, J Pospisilik, H Esterbauer

(2012), Vol. 151, pp. 414-426, Cell, Cambridge, Mass., C1


Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration

M Alejandro Fernndez-Rojo, C Restall, C Ferguson, N Martel, S Martin, M Bosch, A Kassan, G Leong, S Martin, S Mcgee, G Muscat, R Anderson, C Enrich, A Pol, R Parton

(2012), Vol. 55, pp. 1574-1584, Hepatology, C1


Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes

S Hussey, S Mcgee, A Garnham, G Mcconell, M Hargreaves

(2012), Vol. 14, pp. 768-771, Diabetes, Obesity and Metabolism, C1


DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

S McGee, N Sadli, S Morrison, C Swinton, C Suphioglu

(2011), Vol. 28, pp. 157-162, Cellular physiology and biochemistry, Basel, Switzerland, C1


Histone modifications and exercise adaptations

S McGee, M Hargreaves

(2011), Vol. 110, pp. 258-263, Journal of Applied Physiology, C1


Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes

S Hussey, S McGee, A Garnham, J Wentworth, A Jeukendrup, M Hargreaves

(2011), Vol. 13, pp. 959-962, Diabetes, Obesity and Metabolism, C1-1


Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen: Experimental Physiology-Research Paper

W Yeo, S McGee, A Carey, C Paton, A Garnham, M Hargreaves, J Hawley

(2010), Vol. 95, pp. 351-358, Experimental Physiology, C1


AMPK-mediated regulation of transcription in skeletal muscle

S McGee, M Hargreaves

(2010), Vol. 118, pp. 507-518, Clinical Science, C1


Histone modifications and skeletal muscle metabolic gene expression

S McGee, M Hargreaves

(2010), Vol. 37, pp. 392-396, Clinical and Experimental Pharmacology and Physiology, C1


Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1? in human skeletal muscle

M Gibala, S McGee, A Garnham, K Howlett, R Snow, M Hargreaves

(2009), Vol. 106, pp. 929-934, Journal of Applied Physiology, C1


Signalling GLUTtony keeps the sugar coming through glucose transporter expression

S Mcgee

(2009), Vol. 587, pp. 4133-4134, Journal of Physiology, C1


Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations

J Ryu, J Drain, J Kim, S McGee, A Gray-Weale, L Waddington, G Parker, M Hargreaves, S Yoo, D Stapleton

(2009), Vol. 45, pp. 478-482, International Journal of Biological Macromolecules, C1


Exercise-induced histone modifications in human skeletal muscle

S McGee, E Fairlie, A Garnham, M Hargreaves

(2009), Vol. 587, pp. 5951-5958, Journal of Physiology, C1


AMPK and transcriptional regulation

S McGee, M Hargreaves

(2008), Vol. 13, pp. 3022-3033, Frontiers in Bioscience, C1-1


Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

K Burgomaster, K Howarth, S Phillips, M Rakobowchuk, M Macdonald, S Mcgee, M Gibala

(2008), Vol. 586, pp. 151-160, Journal of Physiology, C1-1


Effect of sex differences on human MEF2 regulation during endurance exercise

K Vissing, S McGee, C Roepstorff, P Schjerling, M Hargreaves, B Kiens

(2008), Vol. 294, American Journal of Physiology - Endocrinology and Metabolism, C1-1


Metabolic adaptations to short-term high-intensity interval training: A little pain for a lot of gain?

M Gibala, S McGee

(2008), Vol. 36, pp. 58-63, Exercise and Sport Sciences Reviews, C1-1


AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

S McGee, B Van Denderen, K Howlett, J Mollica, J Schertzer, B Kemp, M Hargreaves

(2008), Vol. 57, pp. 860-867, Diabetes, C1-1


Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase ?1 following overload in LKB1 knockout mice

S Mcgee, K Mustard, D Hardie, K Baar

(2008), Vol. 586, pp. 1731-1741, Journal of Physiology, C1-1


Optimizing training adaptations by manipulating glycogen

K Baar, S McGee

(2008), Vol. 8, pp. 97-106, European journal of sport science, Abingdon, England, C1-1


Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

H Boon, M Bosselaar, S Praet, E Blaak, W Saris, A Wagenmakers, S McGee, C Tack, P Smits, M Hargreaves, L Van Loon

(2008), Vol. 51, pp. 1893-1900, Diabetologia, C1-1


Exercise and MEF2-HDAC interactions.

S McGee

(2007), Vol. 32, pp. 852-856, Applied physiology, nutrition and metabolism, Ottawa, Ontario, C1-1


Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle

S McGee, D Sparling, A Olson, M Hargreaves

(2006), Vol. 20, pp. 348-349, FASEB Journal, C1-1


Exercise and skeletal muscle glucose transporter 4 expression: Molecular mechanisms

S McGee, M Hargreaves

(2006), Vol. 33, pp. 395-399, Clinical and Experimental Pharmacology and Physiology, C1-1


Reduced glycogen availability is associated with increased AMPK?2 activity, nuclear AMPK?2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

G Steinberg, M Watt, S McGee, S Chan, M Hargreaves, M Febbraio, D Stapleton, B Kemp

(2006), Vol. 31, pp. 302-312, Applied Physiology, Nutrition and Metabolism, C1-1


Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression

L Cluberton, S McGee, R Murphy, M Hargreaves

(2005), Vol. 99, pp. 1359-1363, Journal of Applied Physiology, C1-1


Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

S McGee, M Hargreaves

(2004), Vol. 53, pp. 1208-1214, Diabetes, C1


Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: Association with IL-6 gene transcription during contraction

M Chan, S McGee, M Watt, M Hargreaves, M Febbraio

(2004), Vol. 18, pp. 1785-1787, FASEB Journal, C1


Exercise increases nuclear AMPK ?2 in human skeletal muscle

S McGee, K Howlett, R Starkie, D Cameron-Smith, B Kemp, M Hargreaves

(2003), Vol. 52, pp. 926-928, Diabetes, C1


Funded Projects at Deakin

Australian Competitive Grants

HDAC inhibition as an exercise mimetic and treatment for obesity and type 2 diabetes

A/Prof Sean Mcgee

DART Fellowship - Viertel Postdoctoral Fellowship in Diabetes - Diabetes Australia - Victoria (Research Trust)

  • 2011: $75,000
  • 2010: $150,000
  • 2009: $75,000

Molecular mechanisms regulating contraction-induced metabolic gene expression

A/Prof Sean Mcgee

NHMRC - Training PD Award - Peter Doherty Fellowship

  • 2009: $71,250

Activation of HSP72 in skeletal muscle as a therapeutic target for obesity

Prof Mark Febbraio, A/Prof Clinton Bruce, A/Prof Sean Mcgee, Prof Mark Hargreaves

NHMRC Project Grant

  • 2013: $20,000
  • 2012: $20,000

The role of amyloid beta in insulin resistance

A/Prof Sean Mcgee, Prof Ken Walder, Prof Mark Hargreaves

NHMRC Project Grant

  • 2014: $125,826
  • 2013: $138,472
  • 2012: $136,023

Understanding the role of class IIa histone deacetylases in metabolic disease

A/Prof Sean Mcgee, Prof Ken Walder

NHMRC Project Grant

  • 2014: $164,086
  • 2013: $161,714
  • 2012: $143,600

Targeting the class IIa histone deacetylases in metabolic disease

A/Prof Sean Mcgee

NHMRC CDF - Career Development Fellowship

  • 2015: $104,794
  • 2014: $102,941
  • 2013: $101,220
  • 2012: $99,431

Transforming fat to increase energy expenditure

A/Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2013: $59,312

Targeting protein kinase D to treat diabetic cardiomyopathy

A/Prof Sean Mcgee, Dr Kylie Vernados

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $58,592

Targeting class IIa histone deacetylases to impair breast cancer cell metabolism and survival

A/Prof Sean Mcgee

National Breast Cancer Foundation Innovator Grant

  • 2016: $97,690
  • 2015: $98,690

The role of GAPDH acetylation in the regulation of liver metabolism

A/Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2016: $59,983

The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

A/Prof Sean Mcgee, A/Prof Clinton Bruce, Prof Forest White, Prof Ken Walder

NHMRC Project Grant

  • 2019: $161,733
  • 2018: $181,879
  • 2017: $169,227

The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy

A/Prof Sean Mcgee, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2017: $59,962

Role of protein kinase D in adiposity and the regulation of body weight

A/Prof Sean Mcgee, A/Prof Zane Andrews, Prof David James

NHMRC Project Grant

  • 2019: $190,210

Other Public Sector Funding

Development of new exercise mimetics for better treatment of metabolic and heart diseases

A/Prof Sean Mcgee

  • 2019: $100,000

Industry and Other Funding

Proliferation and cell cycle arrest by AMP-activated protein kinase and histone deacetylase 5

A/Prof Sean Mcgee

  • 2009: $9,370

Mechanistically linking type 2 diabetes and Alzheimer's disease

A/Prof Sean Mcgee

  • 2012: $74,290

HDAC Inhibition as a Potential Therapy for Preventing the Progression of Type 2 Diabetes

Dr Kathryn Aston-Mourney, A/Prof Sean Mcgee

  • 2015: $55,000

Identifying the role of altered mitochondrial metabolism in malignant rhabdoid tumours and evaluating potential epigenetic therapies

Prof David Ashley, A/Prof Sean Mcgee, Dr Jason Cain

  • 2016: $23,000

Development of new exercise mimetics for better treatment of metabolic and heart diseases

A/Prof Sean Mcgee

  • 2019: $40,000


Principal Supervisor

Kirstie Anne De Jong

Thesis entitled: Characterisation of the Obese and T2D Heart - Protein Kinase D, a Possible Therapeutic Target

Doctor of Philosophy (Medicine), School of Medicine


Simon Bond

Thesis entitled: The Role of Glyceraldehyde-3-Phosphate Dehydrogenase Acetylation in Liver Metabolism

Doctor of Philosophy (Medicine), School of Medicine


Juliane Czeczor

Thesis entitled: Functional Role of Amyloid b42 in Systemic Glucose Metabolism

Doctor of Philosophy (Medicine), School of Medicine


Vidhi Gaur

Thesis entitled: HDAC inhibition as a therapeutic potential to treat metabolic diseases

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor

Caitlin Murphy

Thesis entitled: Clinical and Molecular Outcomes of a Neo-adjuvant Breast Cancer Trial

MAppSc (Medicine) (High cost), School of Medicine


Shahzad Sadiq

Thesis entitled: Evaluating the Role of Novel microRNAs in Cardiac Hypertrophy

Doctor of Philosophy (Medicine), School of Medicine


Corinna Pade

Thesis entitled: Dissecting the early entry steps of HIV-1 infection

Doctor of Philosophy (Medicine), School of Medicine


Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine