Prof Sean Mcgee

STAFF PROFILE

Position

Professor, Medical Biology

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Graduate Certificate of Higher Education, Deakin University, 2011
Doctor of Philosophy, Deakin University, 2005
Bachelor of Applied Science, Deakin University, 2002

Contact

sean.mcgee@deakin.edu.au
+61 3 522 72519

Biography

Associate Professor McGee obtained his PhD in Molecular Physiology from Deakin University in 2005 and completed postdoctoral training at the Department of Physiology, The University of Melbourne, and The Welcome Trust Biocentre, University of Dundee, Scotland. At the beginning of 2009, relocated his research program to the School of Medicine, Deakin University, where he currently heads the Metabolic Reprogramming Laboratory, within the Metabolic Research Unit.

Read more on Sean's profile

Research interests

Chronic over-nutrition is driving an epidemic of chronic diseases that includes obesity and type 2 diabetes, cardiovascular disease and cancer. Cellular metabolic reprogramming underpins the pathogenesis of all of these diseases. Our laboratory aims to understand the mechanisms that mediate metabolic reprogramming in these diseases and seeks to leverage this knowledge to develop therapies to combat the chronic disease epidemic.

Affiliations

Member of the Australian Diabetes Society, the Australian Physiological Society and the Australian Society for Biochemistry and Molecular Biology.

Teaching interests

Associate Professor McGee is coordinator of the Medical Sciences Metabolism and Musculoskeletal block (HME921) within the Doctor of Medicine degree and also supervisors honours and PhD students.

Knowledge areas

Metabolism, cell signalling, transcription, obesity and type 2 diabetes, cancer metabolism, cardiac metabolism

Professional activities

Diabetes Australia Research Advisory Panel - 2019 to present

National Breast Cancer Foundation Peer Review Committee - 2017

Editorial Board Member, Translational Sport Medicine - 2017 to present

Review Editor in Obesity, Frontiers in Endocrinology - 2016 to present

NHMRC Grant Review Panel Member -  2012, 2013, 2015

Treasurer, Metabolism and Molecular Medicine Special Interest Group, The Australian Society for Biochemistry and Molecular Biology - 2014 to present

Awards

Associate Professor McGee has been awarded research funds totalling in excess of $5 million, with the majority from external National Competitive Grant Schemes, such as the National Health and Medical Research Council (NHMRC), the Diabetes Australia Research Trust (DART) and the National Breast Cancer Foundation. Dr McGee has also been awarded prestigious fellowships, including an NHMRC Peter Doherty Fellowship, the DART Viertel Fellowship and an NHMRC Career Development Fellowship. He was also awarded the AK McIntrye Medal from the Australian Physiological Society in 2010.



 

Publications

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2020

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

J Davey, E Estevez, R Thomson, M Whitham, K Watt, A Hagg, H Qian, D Henstridge, H Ludlow, M Hedger, S McGee, M Coughlan, M Febbraio, P Gregorevic

(2020), Vol. 34, pp. 5697-5714, FASEB journal, Chichester, Eng., C1

journal article

Effects of psychoactive drugs on cellular bioenergetic pathways

Chiara Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Mark Richardson, Nina Vasilijevic, Sheree Martin, Laura Gray, Sean McGee, Michael Berk, Ken Walder

(2020), pp. 1-15, The world journal of biological psychiatry, Abingdon, Eng., C1

journal article

Exercise and GLUT4

M Flores-Opazo, S McGee, M Hargreaves

(2020), Vol. 48, pp. 110-118, Exercise and sport sciences reviews, Philadelphia, Pa., C1

journal article
2019

A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes

Amanda Genders, Sheree Martin, Sean McGee, David Bishop

(2019), Vol. 316, pp. C404-C414, American journal of physiology: cell physiology, Bethesda, Md., C1

journal article

Adhesive capsulitis of the shoulder: protocol for the adhesive capsulitis biomarker (AdCaB) study

Richard Page, Sean McGee, Kevin Eng, Graeme Brown, Sally Beattie, Fiona Collier, Stephen Gill

(2019), Vol. 20, BMC musculoskeletal disorders, London, Eng., C1

journal article

Genetic and epigenetic sex-specific adaptations to endurance exercise

Shanie Landen, Sarah Voisin, Jeffrey Craig, Sean McGee, Sverine Lamon, Nir Eynon

(2019), Vol. 14, pp. 523-535, Epigenetics, Abingdon, Eng., C1

journal article

Class IIa HDACs do not influence beta-cell function under normal or high glucose conditions

Jacob McCann, Megan Ellis, Sean McGee, Kathryn Aston-Mourney

(2019), Vol. 11, pp. 112-118, Islets, Abingdon, Eng., C1

journal article

Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass

A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce

(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1

journal article

Epigenetics and exercise

S McGee, M Hargreaves

(2019), Vol. 30, pp. 636-645, Trends in endocrinology and metabolism, Amsterdam, The Netherlands, C1

journal article

Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

K Hasebe, L Rivera, C Smith, T Allnutt, T Crowley, T Nelson, O Dean, S McGee, K Walder, L Gray

(2019), Vol. 82, pp. 309-318, Brain, behavior, and immunity, Amsterdam, The Netherlands, C1

journal article

Identification of fromiamycalin and halaminol a from australian marine sponge extracts with anthelmintic activity against haemonchus contortus

H Herath, S Preston, A Jabbar, J Garcia-Bustos, A Taki, R Addison, S Hayes, K Beattie, S McGee, S Martin, M Ekins, J Hooper, B Chang, A Hofmann, R Davis, R Gasser

(2019), Vol. 17, pp. 1-14, Marine Drugs, Basel, Switzerland, C1

journal article

A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines

Sheree Martin, Sean McGee

(2019), Vol. 7, pp. 1-14, Cancer & Metabolism, Bingley, Eng., C1

journal article
2018

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

J Wali, S Galic, C Tan, E Gurzov, A Frazier, T Connor, J Ge, E Pappas, D Stroud, L Varanasi, C Selck, M Ryan, D Thorburn, B Kemp, B Krishnamurthy, T Kay, S McGee, H Thomas

(2018), Vol. 25, pp. 217-225, Cell death and differentiation, London, Eng., C1

journal article

Mechanisms underpinning the polypharmacy effects of medications in psychiatry

Chiara Bortolasci, Briana Spolding, Edward Callaly, Sheree Martin, Bruna Panizzutti, Srisaiyini Kidnapillai, Timothy Connor, Kyoko Hasebe, Mohammadreza Mohebbi, Olivia Dean, Sean McGee, Seetal Dodd, Laura Gray, Michael Berk, Ken Walder

(2018), Vol. 21, pp. 582-591, The international journal of neuropsychopharmacology, Oxford, Eng., C1

journal article

Metabolic reprogramming in type 2 diabetes and the development of breast cancer

Sheree Martin, Sean McGee

(2018), Vol. 237, pp. R35-R46, Journal of Endocrinology, Bradley Stok, Eng., C1

journal article

Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression

J Price, Carrie Bronars, Sophie Erhardt, Kathyrn Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean McGee, Mark Frye, Susannah Tye

(2018), Vol. 90, pp. 212-220, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

J Czeczor, A Genders, K Aston-Mourney, T Connor, L Hall, K Hasebe, M Ellis, K De Jong, D Henstridge, P Meikle, M Febbraio, K Walder, S McGee

(2018), Vol. 237, pp. 311-322, Journal of endocrinology, Bradley Stok, Eng., C1

journal article

Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring

K De Jong, S Barrand, R Wood-Bradley, D de Almeida, J Czeczor, G Lopaschuk, J Armitage, S McGee

(2018), Vol. 28, pp. 600-609, Nutrition, metabolism and cardiovascular diseases, Amsterdam, The Netherlands, C1

journal article

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

H Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill Chang, Anson Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin Gasser

(2018), Vol. 8, pp. 379-385, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1

journal article

Exercise and GLUT4 in human subcutaneous adipose tissue

Marcelo Flores-Opazo, Eva Boland, Andrew Garnham, Robyn Murphy, Sean McGee, Mark Hargreaves

(2018), Vol. 6, pp. 1-8, Physiological reports, Chichester, Eng., C1

journal article

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro

H Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill Chang, Anson Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin Gasser

(2018), Vol. 8, pp. 379-385, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1

journal article
2017

A model of the mitochondrial basis of bipolar disorder

G Morris, K Walder, S McGee, O Dean, S Tye, M Maes, M Berk

(2017), Vol. 74, pp. 1-20, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

V Gaur, T Connor, K Venardos, D Henstridge, S Martin, C Swinton, S Morrison, K Aston-Mourney, S Gehrig, R van Ewijk, G Lynch, M Febbraio, G Steinberg, M Hargreaves, K Walder, S McGee

(2017), Vol. 19, pp. 936-943, Diabetes, obesity and metabolism, Chichester, Eng., C1

journal article

Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study

K De Jong, J Czeczor, S Sithara, K McEwen, G Lopaschuk, A Appelbe, K Cukier, M Kotowicz, S McGee

(2017), Vol. 16, pp. 1-12, Cardiovascular diabetology, London, Eng., C1

journal article

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

journal article

Exercise and the skeletal muscle epigenome

S McGee, K Walder

(2017), Vol. 7, Cold Spring Harbor Perspectives in Medicine, Cold Spring Harbor, N.Y., C1

journal article

Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism

J Czeczor, S McGee

(2017), Vol. 29, pp. 1-8, Journal of neuroendocrinology, London, Eng., C1

journal article

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

S Preston, P Korhonen, L Mouchiroud, M Cornaglia, S McGee, N Young, R Davis, S Crawford, C Nowell, B Ansell, G Fisher, K Andrews, B Chang, M Gijs, P Sternberg, J Auwerx, J Baell, A Hofmann, A Jabbar, R Gasser

(2017), Vol. 31, pp. 4515-4532, The FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, Bethesda, Md., C1

journal article
2016

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

M Coughlan, G Higgins, T-V Nguyen, S Penfold, V Thallas-Bonke, S Tan, G Ramm, N Van Bergen, D Henstridge, K Sourris, B Harcourt, I Trounce, P Robb, A Laskowski, S McGee, A Genders, K Walder, B Drew, P Gregorevic, H Qian, M Thomas, G Jerums, R Macisaac, A Skene, D Power, E Ekinci, X Wijeyeratne, L Gallo, M Herman-Edelstein, M Ryan, M Cooper, D Thorburn, J Forbes

(2016), Vol. 65, pp. 1085-1098, Diabetes, Alexandria, Va., C1

journal article

A syntenic cross species aneuploidy genetic screen links RCAN1 expression to ?-cell mitochondrial dysfunction in Type 2 diabetes

H Peiris, M Duffield, J Fadista, C Jessup, V Kashmir, A Genders, S McGee, A Martin, M Saiedi, N Morton, R Carter, M Cousin, A Kokotos, N Oskolkov, P Volkov, T Hough, E Fisher, V Tybulewicz, J Busciglio, P Coskun, A Becker, P Belichenko, W Mobley, M Ryan, J Chan, D Laybutt, P Coates, S Yang, C Ling, L Groop, M Pritchard, D Keating

(2016), Vol. 12, pp. 1-24, PLoS genetics, San Francisco, Calif., C1

journal article

Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

Y Kim, S McGee, J Czeczor, A Walker, R Kale, A Kouzani, K Walder, M Berk, S Tye

(2016), Vol. 6, pp. 1-7, Translational psychiatry, London, Eng., C1

journal article

Epigenetic regulation of skeletal muscle metabolism

K Howlett, S McGee

(2016), Vol. 130, pp. 1051-1063, Clinical science, London, Eng., C1

journal article

Screening of the 'pathogen box' identifies an approved pesticide with major anthelmintic activity against the barber's pole worm

S Preston, Y Jiao, A Jabbar, S McGee, B Laleu, P Willis, T Wells, R Gasser

(2016), Vol. 6, pp. 329-334, International journal for parasitology: drugs and drug resistance, Amsterdam, The Netherlands, C1

journal article

?-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Mller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschp, M Watt, I Clarke, C Roth, K Grove, M Cowley

(2016), Vol. 5, pp. 807-822, Molecular metabolism, Amsterdam, The Netherlands, C1

journal article

Disruption of the class IIa HDAC corepressor complex increases energy expenditure and lipid oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell reports, New York, N.Y., C1

journal article
2015

Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

T Connor, S Martin, K Howlett, S McGee

(2015), Vol. 42, pp. 109-115, Clinical and Experimental Pharmacology and Physiology, England, London, C1

journal article

N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

D Wright, T Renoir, Z Smith, A Frazier, P Francis, D Thorburn, S McGee, A Hannan, L Gray

(2015), Vol. 5, pp. 1-10, Translational psychiatry, New York, N. Y., C1

journal article

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.

C Wilson, S Shalini, A Filipovska, T Richman, S Davies, S Martin, S McGee, J Puccini, A Nikolic, L Dorstyn, S Kumar

(2015), Vol. 6, pp. e1597-e1597, Cell Death and Disease, England, C1

journal article

The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice

K Venardos, K De Jong, M Elkamie, T Connor, S McGee

(2015), Vol. 10, pp. 1-14, PLoS one, San Francisco, Calif., C1-1

journal article

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt

(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1

journal article

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

journal article

Lipid abundance in zebrafish embryos is regulated by complementary actions of the endocannabinoid system and retinoic acid pathway

D Fraher, M Ellis, S Morrison, S McGee, A Ward, K Walder, Y Gibert

(2015), Vol. 156, pp. 3596-3609, Endocrinology, Bethesda, Md., C1

journal article

3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages

S Morrison, S McGee

(2015), Vol. 4, pp. 295-302, Adipocyte, London, Eng., C1

journal article
2014

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio

(2014), Vol. 63, pp. 1881-1894, Diabetes, C1

journal article

Improved synthesis and structural reassignment of MC1568: A class IIa selective HDAC inhibitor

C Fleming, T Ashton, V Gaur, S McGee, F Pfeffer

(2014), Vol. 57, pp. 1132-1135, Journal of Medicinal Chemistry, C1

journal article

Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

S Martin, S Morrison, N Konstantopoulos, S McGee

(2014), Vol. 3, pp. 408-418, Molecular metabolism, Amsterdam, Netherlands, C1

journal article

Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury

D Williams, K Venardos, M Byrne, M Joshi, D Horlock, N Lam, P Gregorevic, S McGee, D Kaye

(2014), Vol. 9, pp. 1-11, PLoS one, San Francisco, CA, C1

journal article

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis

T Parmenter, M Kleinschmidt, K Kinross, S Bond, J Li, M Kaadige, A Rao, K Sheppard, W Hugo, G Pupo, R Pearson, S McGee, G Long, R Scolyer, H Rizos, R Lo, C Cullinane, D Ayer, A Ribas, R Johnstone, R Hicks, G McArthur

(2014), Vol. 4, pp. 423-433, Cancer Discovery, Philadelphia, PA, C1

journal article

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress

S McGee, C Swinton, S Morrison, V Gaur, D Campbell, S Jorgensen, B Kemp, K Baar, G Steinberg, M Hargreaves

(2014), Vol. 28, pp. 3384-3395, FASEB journal, Bethesda, MD, C1

journal article

The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes

S Martin, S McGee

(2014), Vol. 1840, pp. 1303-1312, Biochimica et biophysica acta, Amsterdam, The Netherlands, C1

journal article
2013

Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals

K Vissing, S Mcgee, J Farup, T Kjlhede, M Vendelbo, N Jessen

(2013), Vol. 23, pp. 355-366, Scandinavian Journal of Medicine and Science in Sports, C1

journal article

Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels

A Walker, S Burnett, K Hasebe, J McGillivray, L Gray, S McGee, K Walder, M Berk, S Tye

(2013), Vol. 242, pp. 76-83, Behavioural Brain Research, C1

journal article

Effect of DHA and CoenzymeQ10 against A?- and zinc-induced mitochondrial dysfunction in human neuronal cells

N Sadli, C Barrow, S McGee, C Suphioglu

(2013), Vol. 32, pp. 243-252, Cellular Physiology and Biochemistry, C1

journal article

Metabolic profile analysis of zebrafish embryos

Y Gibert, S McGee, A Ward

(2013), Vol. 71, pp. 1-5, Journal of visualized experiments, Cambridge, Mass., C1

journal article

Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism

S Richter, S Morrison, T Connor, J Su, C Print, R Ronimus, S McGee, W Wilson

(2013), Vol. 8, PLoS ONE, C1

journal article

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

C Winbanks, J Chen, H Qian, Y Liu, B Bernardo, C Beyer, K Watt, R Thomson, T Connor, B Turner, J McMullen, L Larsson, S McGee, C Harrison, P Gregorevic

(2013), Vol. 203, pp. 345-357, Journal of Cell Biology, C1

journal article

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

W Sanchez, S McGee, T Connor, B Mottram, A Wilkinson, J Whitehead, S Vuckovic, L Catley

(2013), Vol. 108, pp. 1624-1633, British Journal of Cancer, C1

journal article

Skeletal muscle fat metabolism after exercise in humans: Influence of fat availability

N Kimber, D Cameron-Smith, S McGee, M Hargreaves

(2013), Vol. 114, pp. 1577-1585, Journal of Applied Physiology, C1

journal article

Caveolin-1 is necessary for hepatic oxidative lipid metabolism: Evidence for crosstalk between caveolin-1 and bile acid signaling

M Fernndez-Rojo, M Gongora, R Fitzsimmons, N Martel, S Martin, S Nixon, A Brooks, M Ikonomopoulou, S Martin, H Lo, S Myers, C Restall, C Ferguson, P Pilch, S McGee, R Anderson, M Waters, J Hancock, S Grimmond, G Muscat, R Parton

(2013), Vol. 4, pp. 238-247, Cell Reports, C1

journal article
2012

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo

N Konstantopoulos, J Molero, S McGee, B Spolding, T Connor, M De Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, V Foletta, G Krippner, S Andrikopoulos, K Walder

(2012), Vol. 61, pp. 2146-2154, Diabetes, C1

journal article

Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

S Raichur, S Teh, K Ohwaki, V Gaur, Y Long, M Hargreaves, S McGee, J Kusunoki

(2012), Vol. 49, pp. 203-211, Journal of Molecular Endocrinology, C1

journal article

Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat

R Teperino, S Amann, M Bayer, S McGee, A Loipetzberger, T Connor, C Jaeger, B Kammerer, L Winter, G Wiche, K Dalgaard, M Selvaraj, M Gaster, R Lee-Young, M Febbraio, C Knauf, P Cani, F Aberger, J Penniger, J Pospisilik, H Esterbauer

(2012), Vol. 151, pp. 414-426, Cell, Cambridge, Mass., C1

journal article

Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: Implications for liver regeneration

M Alejandro Fernndez-Rojo, C Restall, C Ferguson, N Martel, S Martin, M Bosch, A Kassan, G Leong, S Martin, S Mcgee, G Muscat, R Anderson, C Enrich, A Pol, R Parton

(2012), Vol. 55, pp. 1574-1584, Hepatology, C1

journal article

Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes

S Hussey, S Mcgee, A Garnham, G Mcconell, M Hargreaves

(2012), Vol. 14, pp. 768-771, Diabetes, Obesity and Metabolism, C1

journal article
2011

DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

S McGee, N Sadli, S Morrison, C Swinton, C Suphioglu

(2011), Vol. 28, pp. 157-162, Cellular Physiology and Biochemistry, C1

journal article

Histone modifications and exercise adaptations

S McGee, M Hargreaves

(2011), Vol. 110, pp. 258-263, Journal of Applied Physiology, C1

journal article

Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes

S Hussey, S McGee, A Garnham, J Wentworth, A Jeukendrup, M Hargreaves

(2011), Vol. 13, pp. 959-962, Diabetes, Obesity and Metabolism, C1-1

journal article
2010

Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen: Experimental Physiology-Research Paper

W Yeo, S McGee, A Carey, C Paton, A Garnham, M Hargreaves, J Hawley

(2010), Vol. 95, pp. 351-358, Experimental Physiology, C1

journal article

AMPK-mediated regulation of transcription in skeletal muscle

S McGee, M Hargreaves

(2010), Vol. 118, pp. 507-518, Clinical Science, C1

journal article

Histone modifications and skeletal muscle metabolic gene expression

S McGee, M Hargreaves

(2010), Vol. 37, pp. 392-396, Clinical and Experimental Pharmacology and Physiology, C1

journal article
2009

Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1? in human skeletal muscle

M Gibala, S McGee, A Garnham, K Howlett, R Snow, M Hargreaves

(2009), Vol. 106, pp. 929-934, Journal of Applied Physiology, C1

journal article

Signalling GLUTtony keeps the sugar coming through glucose transporter expression

S Mcgee

(2009), Vol. 587, pp. 4133-4134, Journal of Physiology, C1

journal article

Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations

J Ryu, J Drain, J Kim, S McGee, A Gray-Weale, L Waddington, G Parker, M Hargreaves, S Yoo, D Stapleton

(2009), Vol. 45, pp. 478-482, International Journal of Biological Macromolecules, C1

journal article

Exercise-induced histone modifications in human skeletal muscle

S McGee, E Fairlie, A Garnham, M Hargreaves

(2009), Vol. 587, pp. 5951-5958, Journal of Physiology, C1

journal article
2008

AMPK and transcriptional regulation

S McGee, M Hargreaves

(2008), Vol. 13, pp. 3022-3033, Frontiers in Bioscience, C1-1

journal article

Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

K Burgomaster, K Howarth, S Phillips, M Rakobowchuk, M Macdonald, S Mcgee, M Gibala

(2008), Vol. 586, pp. 151-160, Journal of Physiology, C1-1

journal article

Effect of sex differences on human MEF2 regulation during endurance exercise

K Vissing, S McGee, C Roepstorff, P Schjerling, M Hargreaves, B Kiens

(2008), Vol. 294, American Journal of Physiology - Endocrinology and Metabolism, C1-1

journal article

Metabolic adaptations to short-term high-intensity interval training: A little pain for a lot of gain?

M Gibala, S McGee

(2008), Vol. 36, pp. 58-63, Exercise and Sport Sciences Reviews, C1-1

journal article

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

S McGee, B Van Denderen, K Howlett, J Mollica, J Schertzer, B Kemp, M Hargreaves

(2008), Vol. 57, pp. 860-867, Diabetes, C1-1

journal article

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase ?1 following overload in LKB1 knockout mice

S Mcgee, K Mustard, D Hardie, K Baar

(2008), Vol. 586, pp. 1731-1741, Journal of Physiology, C1-1

journal article

Optimizing training adaptations by manipulating glycogen

K Baar, S McGee

(2008), Vol. 8, pp. 97-106, European journal of sport science, Abingdon, England, C1-1

journal article

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

H Boon, M Bosselaar, S Praet, E Blaak, W Saris, A Wagenmakers, S McGee, C Tack, P Smits, M Hargreaves, L Van Loon

(2008), Vol. 51, pp. 1893-1900, Diabetologia, C1-1

journal article
2007

Exercise and MEF2-HDAC interactions

S McGee

(2007), Vol. 32, pp. 852-856, Applied Physiology, Nutrition and Metabolism, C1-1

journal article
2006

Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle

S McGee, D Sparling, A Olson, M Hargreaves

(2006), Vol. 20, pp. 348-349, FASEB Journal, C1-1

journal article

Exercise and skeletal muscle glucose transporter 4 expression: Molecular mechanisms

S McGee, M Hargreaves

(2006), Vol. 33, pp. 395-399, Clinical and Experimental Pharmacology and Physiology, C1-1

journal article

Reduced glycogen availability is associated with increased AMPK?2 activity, nuclear AMPK?2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle

G Steinberg, M Watt, S McGee, S Chan, M Hargreaves, M Febbraio, D Stapleton, B Kemp

(2006), Vol. 31, pp. 302-312, Applied Physiology, Nutrition and Metabolism, C1-1

journal article
2005

Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression

L Cluberton, S McGee, R Murphy, M Hargreaves

(2005), Vol. 99, pp. 1359-1363, Journal of Applied Physiology, C1-1

journal article
2004

Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

S McGee, M Hargreaves

(2004), Vol. 53, pp. 1208-1214, Diabetes, C1

journal article

Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: Association with IL-6 gene transcription during contraction

M Chan, S McGee, M Watt, M Hargreaves, M Febbraio

(2004), Vol. 18, pp. 1785-1787, FASEB Journal, C1

journal article
2003

Exercise increases nuclear AMPK ?2 in human skeletal muscle

S McGee, K Howlett, R Starkie, D Cameron-Smith, B Kemp, M Hargreaves

(2003), Vol. 52, pp. 926-928, Diabetes, C1

journal article

Funded Projects at Deakin

Australian Competitive Grants

HDAC inhibition as an exercise mimetic and treatment for obesity and type 2 diabetes

Prof Sean Mcgee

DART Fellowship - Viertel Postdoctoral Fellowship in Diabetes - Diabetes Australia - Victoria (Research Trust)

  • 2011: $75,000
  • 2010: $150,000
  • 2009: $75,000

Molecular mechanisms regulating contraction-induced metabolic gene expression

Prof Sean Mcgee

NHMRC - Training PD Award - Peter Doherty Fellowship

  • 2009: $71,250

Activation of HSP72 in skeletal muscle as a therapeutic target for obesity

Prof Mark Febbraio, A/Prof Clinton Bruce, Prof Sean Mcgee, Prof Mark Hargreaves

NHMRC Project Grant

  • 2013: $20,000
  • 2012: $20,000

The role of amyloid beta in insulin resistance

Prof Sean Mcgee, Prof Ken Walder, Prof Mark Hargreaves

NHMRC Project Grant

  • 2014: $125,826
  • 2013: $138,472
  • 2012: $136,023

Understanding the role of class IIa histone deacetylases in metabolic disease

Prof Sean Mcgee, Prof Ken Walder

NHMRC Project Grant

  • 2014: $164,086
  • 2013: $161,714
  • 2012: $143,600

Targeting the class IIa histone deacetylases in metabolic disease

Prof Sean Mcgee

NHMRC CDF - Career Development Fellowship

  • 2015: $104,794
  • 2014: $102,941
  • 2013: $101,220
  • 2012: $99,431

Transforming fat to increase energy expenditure

Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2013: $59,312

Targeting protein kinase D to treat diabetic cardiomyopathy

Prof Sean Mcgee, Dr Kylie Vernados

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2015: $58,592

Targeting class IIa histone deacetylases to impair breast cancer cell metabolism and survival

Prof Sean Mcgee

National Breast Cancer Foundation Innovator Grant

  • 2016: $97,690
  • 2015: $98,690

The role of GAPDH acetylation in the regulation of liver metabolism

Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2016: $59,983

The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

Prof Sean Mcgee, A/Prof Clinton Bruce, Prof Forest White, Prof Ken Walder

NHMRC Project Grant

  • 2020: $10,462
  • 2019: $187,097
  • 2018: $181,879
  • 2017: $169,227

The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy

Prof Sean Mcgee, A/Prof Clinton Bruce

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2017: $59,962

Role of protein kinase D in adiposity and the regulation of body weight

Prof Sean Mcgee, A/Prof Zane Andrews, Prof David James

NHMRC Project Grant

  • 2020: $23,586
  • 2019: $181,854

A novel approach to target beta-cells to enhance survival and function

Dr Kathryn Aston-Mourney, Dr Sarah Shigdar, Prof Sean Mcgee

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2020: $59,756

Other Public Sector Funding

Development of new exercise mimetics for better treatment of metabolic and heart diseases

Prof Sean Mcgee

  • 2019: $100,000

Industry and Other Funding

Proliferation and cell cycle arrest by AMP-activated protein kinase and histone deacetylase 5

Prof Sean Mcgee

  • 2009: $9,370

Mechanistically linking type 2 diabetes and Alzheimer's disease

Prof Sean Mcgee

  • 2012: $74,290

HDAC Inhibition as a Potential Therapy for Preventing the Progression of Type 2 Diabetes

Dr Kathryn Aston-Mourney, Prof Sean Mcgee

  • 2015: $55,000

Identifying the role of altered mitochondrial metabolism in malignant rhabdoid tumours and evaluating potential epigenetic therapies

Prof David Ashley, Prof Sean Mcgee, Dr Jason Cain

  • 2016: $23,000

Development of new exercise mimetics for better treatment of metabolic and heart diseases

Prof Sean Mcgee

  • 2020: $60,000
  • 2019: $40,000

New therapies for obesity-induced heart disease.

Prof Sean Mcgee

  • 2020: $60,000

Supervisions

Principal Supervisor
2020

Joshua Blair Price

Thesis entitled: Investigating Mechanisms of Stress, Inflammation, and Bioenergetics in Treatment-resistant Depression

Doctor of Philosophy (Medicine), School of Medicine

2018

Kirstie Anne De Jong

Thesis entitled: Characterisation of the Obese and T2D Heart - Protein Kinase D, a Possible Therapeutic Target

Doctor of Philosophy (Medicine), School of Medicine

2016

Simon Bond

Thesis entitled: The Role of Glyceraldehyde-3-Phosphate Dehydrogenase Acetylation in Liver Metabolism

Doctor of Philosophy (Medicine), School of Medicine

2015

Juliane Czeczor

Thesis entitled: Functional Role of Amyloid b42 in Systemic Glucose Metabolism

Doctor of Philosophy (Medicine), School of Medicine

2014

Vidhi Gaur

Thesis entitled: HDAC inhibition as a therapeutic potential to treat metabolic diseases

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2019

Caitlin Murphy

Thesis entitled: Clinical and Molecular Outcomes of a Neo-adjuvant Breast Cancer Trial

MAppSc (Medicine) (High cost), School of Medicine

2018

Shahzad Sadiq

Thesis entitled: Evaluating the Role of Novel microRNAs in Cardiac Hypertrophy

Doctor of Philosophy (Medicine), School of Medicine

2016

Corinna Pade

Thesis entitled: Dissecting the early entry steps of HIV-1 infection

Doctor of Philosophy (Medicine), School of Medicine

2015

Sivapriya Pavuluri

Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma

Doctor of Philosophy (Medicine), School of Medicine