Biography
Associate Professor McGee obtained his PhD in Molecular Physiology from Deakin University in 2005 and completed postdoctoral training at the Department of Physiology, The University of Melbourne, and The Welcome Trust Biocentre, University of Dundee, Scotland. At the beginning of 2009, relocated his research program to the School of Medicine, Deakin University, where he currently heads the Metabolic Reprogramming Laboratory, within the Metabolic Research Unit.
Read more on Sean's profileResearch interests
Chronic over-nutrition is driving an epidemic of chronic diseases that includes obesity and type 2 diabetes, cardiovascular disease and cancer. Cellular metabolic reprogramming underpins the pathogenesis of all of these diseases. Our laboratory aims to understand the mechanisms that mediate metabolic reprogramming in these diseases and seeks to leverage this knowledge to develop therapies to combat the chronic disease epidemic.
Affiliations
Member of the Australian Diabetes Society, the Australian Physiological Society and the Australian Society for Biochemistry and Molecular Biology.
Teaching interests
Associate Professor McGee is coordinator of the Medical Sciences Metabolism and Musculoskeletal block (HME921) within the Doctor of Medicine degree and also supervisors honours and PhD students.
Knowledge areas
Metabolism, cell signalling, transcription, obesity and type 2 diabetes, cancer metabolism, cardiac metabolism
Professional activities
Diabetes Australia Research Advisory Panel - 2019 to present
National Breast Cancer Foundation Peer Review Committee - 2017
Editorial Board Member, Translational Sport Medicine - 2017 to present
Review Editor in Obesity, Frontiers in Endocrinology - 2016 to present
NHMRC Grant Review Panel Member - 2012, 2013, 2015
Treasurer, Metabolism and Molecular Medicine Special Interest Group, The Australian Society for Biochemistry and Molecular Biology - 2014 to present
Awards
Associate Professor McGee has been awarded research funds totalling in excess of $5 million, with the majority from external National Competitive Grant Schemes, such as the National Health and Medical Research Council (NHMRC), the Diabetes Australia Research Trust (DART) and the National Breast Cancer Foundation. Dr McGee has also been awarded prestigious fellowships, including an NHMRC Peter Doherty Fellowship, the DART Viertel Fellowship and an NHMRC Career Development Fellowship. He was also awarded the AK McIntrye Medal from the Australian Physiological Society in 2010.
Publications
Biomarkers of Osteoarthritis-A Narrative Review on Causal Links with Metabolic Syndrome
Sam Lynskey, Marc Macaluso, Stephen Gill, Sean Mcgee, Richard Page
(2023), Vol. 13, pp. 730-730, Life, Basel, Switzerland, C1
C Bortolasci, S Kidnapillai, B Spolding, T Truong, T Connor, C Swinton, B Panizzutti, Z Liu, A Sanigorski, O Dean, T Crowley, M Richardson, K Bozaoglu, K Vlahos, S Cowdery, B Watmuff, S Steyn, D Wolmarans, B Engelbrecht, C Perry, K Drummond, T Pang, S Jamain, L Gray, S McGee, B Harvey, J Kim, M Leboyer, M Berk, K Walder
(2023), Bipolar Disorders, C1
K de Jong, F Berisha, N Naderpoor, A Appelbe, M Kotowicz, K Cukier, S McGee, V Nikolaev
(2022), Vol. 17, pp. 1-10, PLoS ONE, San Francisco, Calif., C1
W Naser, S Maymand, L Rivera, T Connor, C Liongue, C Smith, K Aston-Mourney, D McCulloch, S McGee, A Ward
(2022), Vol. 36, pp. 1-15, FASEB Journal, London, Eng., C1
Effects of psychotropic drugs on ribosomal genes and protein synthesis
Zoe Liu, Trang Truong, Chiara Bortolasci, Briana Spolding, Bruna Panizzutti, Courtney Swinton, Jee Kim, Srisaiyini Kidnapillai, Mark Richardson, Laura Gray, Olivia Dean, Sean McGee, Michael Berk, Ken Walder
(2022), Vol. 23, pp. 7180-7180, International Journal of Molecular Sciences, Basel, Switzerland, C1
Effects of psychoactive drugs on cellular bioenergetic pathways
C Bortolasci, B Spolding, S Kidnapillai, M Richardson, N Vasilijevic, S Martin, L Gray, S McGee, M Berk, K Walder
(2021), Vol. 22, pp. 79-93, World Journal of Biological Psychiatry, England, C1
J Mousley, L Hill-Buxton, S Gill, S McGee, R Page
(2021), Vol. 30, pp. 200-215, Journal of shoulder and elbow surgery, Amsterdam, The Netherlands, C1
M Renton, S McGee, K Howlett
(2021), Vol. 22, Obesity Reviews, England, C1
1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity
S Preston, J Garcia-Bustos, L Hall, S Martin, T Le, A Kundu, A Ghoshal, N Nguyen, Y Jiao, B Ruan, L Xue, F Huang, B Chang, S McGee, T Wells, M Palmer, A Jabbar, R Gasser, J Baell
(2021), Vol. 64, pp. 840-844, Journal of medicinal chemistry, Washington, D.C., C1
J Price, C Yates, B Morath, S Van De Wakker, N Yates, K Butters, M Frye, S McGee, S Tye
(2021), Vol. 11, Translational Psychiatry, United States, C1
J Davey, E Estevez, R Thomson, M Whitham, K Watt, A Hagg, H Qian, D Henstridge, H Ludlow, M Hedger, S McGee, M Coughlan, M Febbraio, P Gregorevic
(2020), Vol. 34, pp. 5697-5714, FASEB journal, Chichester, Eng., C1
Transcriptomic analysis of adhesive capsulitis of the shoulder
Nima Kamal, Sean Mcgee, Kevin Eng, Graeme Brown, Sally Beattie, Fiona Collier, Stephen Gill, Richard Page
(2020), Vol. 38, pp. 2280-2289, Journal of Orthopaedic Research, Hoboken. N.J., C1
Integrated analysis of a compendium of RNA-Seq datasets for splicing factors
P Yu, J Li, S Deng, F Zhang, P Grozdanov, E Chin, S Martin, L Vergnes, M Islam, D Sun, J LaSalle, S McGee, E Goh, C MacDonald, P Jin
(2020), Vol. 7, Scientific Data, England, C1
M Flores-Opazo, S McGee, M Hargreaves
(2020), Vol. 48, pp. 110-118, Exercise and Sport Sciences Reviews, United States, C1
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
S McGee, M Hargreaves
(2020), Vol. 16, pp. 495-505, Nature Reviews Endocrinology, London, Eng., C1
Reducing hepatic PKD activity lowers circulating VLDL cholesterol
Amanda Genders, Timothy Connor, Shona Morrison, Simon Bond, Brian Drew, Peter Meikle, Kirsten Howlett, Sean Mcgee
(2020), Vol. 246, pp. 265-276, Journal of Endocrinology, Bristol, Eng., C1
K De Jong, L Hall, M Renton, T Connor, S Martin, G Kowalski, C Shaw, C Bruce, K Howlett, S McGee
(2020), Vol. 42, Molecular Metabolism, Germany, C1
A Genders, S Martin, S McGee, D Bishop
(2019), Vol. 316, pp. C404-C414, American Journal of Physiology - Cell Physiology, United States, C1
Adhesive capsulitis of the shoulder: protocol for the adhesive capsulitis biomarker (AdCaB) study
R Page, S McGee, K Eng, G Brown, S Beattie, F Collier, S Gill
(2019), Vol. 20, BMC Musculoskeletal Disorders, England, C1
Genetic and epigenetic sex-specific adaptations to endurance exercise
S Landen, S Voisin, J Craig, S McGee, S Lamon, N Eynon
(2019), Vol. 14, pp. 523-535, Epigenetics, United States, C1
Class IIa HDACs do not influence beta-cell function under normal or high glucose conditions
J McCann, M Ellis, S McGee, K Aston-Mourney
(2019), Vol. 11, pp. 112-118, Islets, United States, C1
A Selathurai, G Kowalski, S Mason, D Callahan, V Foletta, P Della Gatta, A Lindsay, S Hamley, G Kaur, A Curtis, M Burch, T Ang, S McGee, C Bruce
(2019), Vol. 27, pp. 33-46, Molecular metabolism, Amsterdam, The Netherlands, C1
S McGee, M Hargreaves
(2019), Vol. 30, pp. 636-645, Trends in endocrinology and metabolism, Amsterdam, The Netherlands, C1
Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline
K Hasebe, L Rivera, C Smith, T Allnutt, T Crowley, T Nelson, O Dean, S McGee, K Walder, L Gray
(2019), Vol. 82, pp. 309-318, Brain, Behavior, and Immunity, Netherlands, C1
H Herath, S Preston, A Jabbar, J Garcia-Bustos, A Taki, R Addison, S Hayes, K Beattie, S McGee, S Martin, M Ekins, J Hooper, B Chang, A Hofmann, R Davis, R Gasser
(2019), Vol. 17, Marine Drugs, Switzerland, C1
Sheree Martin, Sean McGee
(2019), Vol. 7, CANCER & METABOLISM, England, C1
J Wali, S Galic, C Tan, E Gurzov, A Frazier, T Connor, J Ge, E Pappas, D Stroud, L Varanasi, C Selck, M Ryan, D Thorburn, B Kemp, B Krishnamurthy, T Kay, S McGee, H Thomas
(2018), Vol. 25, pp. 217-225, Cell Death and Differentiation, England, C1
Mechanisms underpinning the polypharmacy effects of medications in psychiatry
C Bortolasci, B Spolding, E Callaly, S Martin, B Panizzutti, S Kidnapillai, T Connor, K Hasebe, M Mohebbi, O Dean, S McGee, S Dodd, L Gray, M Berk, K Walder
(2018), Vol. 21, pp. 582-591, International Journal of Neuropsychopharmacology, England, C1
Metabolic reprogramming in type 2 diabetes and the development of breast cancer
Sheree Martin, Sean McGee
(2018), Vol. 237, pp. R35-R46, Journal of Endocrinology, Bradley Stok, Eng., C1
J Price, Carrie Bronars, Sophie Erhardt, Kathyrn Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean McGee, Mark Frye, Susannah Tye
(2018), Vol. 90, pp. 212-220, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1
APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding
J Czeczor, A Genders, K Aston-Mourney, T Connor, L Hall, K Hasebe, M Ellis, K De Jong, D Henstridge, P Meikle, M Febbraio, K Walder, S McGee
(2018), Vol. 237, pp. 311-322, Journal of Endocrinology, England, C1
K De Jong, S Barrand, R Wood-Bradley, D de Almeida, J Czeczor, G Lopaschuk, J Armitage, S McGee
(2018), Vol. 28, pp. 600-609, Nutrition, metabolism and cardiovascular diseases, Amsterdam, The Netherlands, C1
H Dilrukshi Herath, H Song, S Preston, A Jabbar, T Wang, S McGee, A Hofmann, J Garcia-Bustos, B Chang, A Koehler, Y Liu, Q Ma, P Zhang, Q Zhao, Q Wang, R Gasser
(2018), Vol. 8, pp. 379-385, International Journal for Parasitology: Drugs and Drug Resistance, Netherlands, C1
Exercise and GLUT4 in human subcutaneous adipose tissue
M Flores-Opazo, E Boland, A Garnham, R Murphy, S McGee, M Hargreaves
(2018), Vol. 6, Physiological Reports, United States, C1
A model of the mitochondrial basis of bipolar disorder
G Morris, K Walder, S McGee, O Dean, S Tye, M Maes, M Berk
(2017), Vol. 74, pp. 1-20, Neuroscience and Biobehavioral Reviews, United States, C1
Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice
V Gaur, T Connor, K Venardos, D Henstridge, S Martin, C Swinton, S Morrison, K Aston-Mourney, S Gehrig, R van Ewijk, G Lynch, M Febbraio, G Steinberg, M Hargreaves, K Walder, S McGee
(2017), Vol. 19, pp. 936-943, Diabetes, Obesity and Metabolism, England, C1
K Jong, J Czeczor, S Sithara, K McEwen, G Loopaschuk, A Appelbe, K Cukier, M Kotowicz, S McGee
(2017), Vol. 16, Cardiovascular Diabetology, England, C1
S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee
(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1
Exercise and the skeletal muscle epigenome
S McGee, K Walder
(2017), Vol. 7, Cold Spring Harbor Perspectives in Medicine, United States, C1
J Czeczor, S McGee
(2017), Vol. 29, Journal of Neuroendocrinology, United States, C1
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
S Preston, P Korhonen, L Mouchiroud, M Cornaglia, S McGee, N Young, R Davis, S Crawford, C Nowell, B Ansell, G Fisher, K Andrews, B Chang, M Gijs, P Sternberg, J Auwerx, J Baell, A Hofmann, A Jabbar, R Gasser
(2017), Vol. 31, pp. 4515-4532, FASEB Journal, United States, C1
M Coughlan, G Higgins, T Nguyen, S Penfold, V Thallas-Bonke, S Tan, G Ramm, N Van Bergen, D Henstridge, K Sourris, B Harcourt, I Trounce, P Robb, A Laskowski, S McGee, A Genders, K Walder, B Drew, P Gregorevic, H Qian, M Thomas, G Jerums, R Macisaac, A Skene, D Power, E Ekinci, X Wijeyeratne, L Gallo, M Herman-Edelstein, M Ryan, M Cooper, D Thorburn, J Forbes
(2016), Vol. 65, pp. 1085-1098, Diabetes, United States, C1
H Peiris, M Duffield, J Fadista, C Jessup, V Kashmir, A Genders, S McGee, A Martin, M Saiedi, N Morton, R Carter, M Cousin, A Kokotos, N Oskolkov, P Volkov, T Hough, E Fisher, V Tybulewicz, J Busciglio, P Coskun, A Becker, P Belichenko, W Mobley, M Ryan, J Chan, D Laybutt, P Coates, S Yang, C Ling, L Groop, M Pritchard, D Keating
(2016), Vol. 12, PLoS Genetics, United States, C1
Y Kim, S McGee, J Czeczor, A Walker, R Kale, A Kouzani, K Walder, M Berk, S Tye
(2016), Vol. 6, pp. e842-, Translational psychiatry, United States, C1
Epigenetic regulation of skeletal muscle metabolism
K Howlett, S McGee
(2016), Vol. 130, pp. 1051-1063, Clinical Science, England, C1
S Preston, Y Jiao, A Jabbar, S McGee, B Laleu, P Willis, T Wells, R Gasser
(2016), Vol. 6, pp. 329-334, International Journal for Parasitology: Drugs and Drug Resistance, Netherlands, C1
α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
P Enriori, W Chen, M Garcia-Rudaz, B Grayson, A Evans, S Comstock, U Gebhardt, H Müller, T Reinehr, B Henry, R Brown, C Bruce, S Simonds, S Litwak, S McGee, S Luquet, S Martinez, M Jastroch, M Tschöp, M Watt, I Clarke, C Roth, K Grove, M Cowley
(2016), Vol. 5, pp. 807-822, Molecular Metabolism, Germany, C1
V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee
(2016), Vol. 16, pp. 2802-2810, Cell Reports, United States, C1
T Connor, S Martin, K Howlett, S McGee
(2015), Vol. 42, pp. 109-115, Clinical and Experimental Pharmacology and Physiology, England, London, C1
D Wright, T Renoir, Z Smith, A Frazier, P Francis, D Thorburn, S McGee, A Hannan, L Gray
(2015), Vol. 5, pp. 1-10, Translational psychiatry, New York, N. Y., C1
Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.
C Wilson, S Shalini, A Filipovska, T Richman, S Davies, S Martin, S McGee, J Puccini, A Nikolic, L Dorstyn, S Kumar
(2015), Vol. 6, pp. e1597-e1597, Cell Death and Disease, England, C1
The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice
K Venardos, K De Jong, M Elkamie, T Connor, S McGee
(2015), Vol. 10, pp. 1-14, PLoS one, San Francisco, Calif., C1-1
ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle
R Meex, A Hoy, R Mason, S Martin, S McGee, C Bruce, M Watt
(2015), Vol. 308, pp. E960-E970, AJP - Endocrinology and metabolism, Bethesda, MD, C1
A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce
(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1
D Fraher, M Ellis, S Morrison, S McGee, A Ward, K Walder, Y Gibert
(2015), Vol. 156, pp. 3596-3609, Endocrinology, Bethesda, Md., C1
3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages
S Morrison, S McGee
(2015), Vol. 4, pp. 295-302, Adipocyte, London, Eng., C1
Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance
D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio
(2014), pp. 1-1, Diabetes, Alexandria, Virginia, C1
Improved synthesis and structural reassignment of MC1568 : a class IIa selective HDAC inhibitor
C Fleming, T Ashton, V Gaur, S McGee, F Pfeffer
(2014), Vol. 57, pp. 1132-1135, Journal of medicinal chemistry, Washington, DC, C1
Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action
S Martin, S Morrison, N Konstantopoulos, S McGee
(2014), Vol. 3, pp. 408-418, Molecular metabolism, Amsterdam, Netherlands, C1
D Williams, K Venardos, M Byrne, M Joshi, D Horlock, N Lam, P Gregorevic, S McGee, D Kaye
(2014), Vol. 9, pp. 1-11, PLoS one, San Francisco, CA, C1
T Parmenter, M Kleinschmidt, K Kinross, S Bond, J Li, M Kaadige, A Rao, K Sheppard, W Hugo, G Pupo, R Pearson, S McGee, G Long, R Scolyer, H Rizos, R Lo, C Cullinane, D Ayer, A Ribas, R Johnstone, R Hicks, G McArthur
(2014), Vol. 4, pp. 423-433, Cancer Discovery, Philadelphia, PA, C1
S McGee, C Swinton, S Morrison, V Gaur, D Campbell, S Jorgensen, B Kemp, K Baar, G Steinberg, M Hargreaves
(2014), Vol. 28, pp. 3384-3395, FASEB journal, Bethesda, MD, C1
The role of mitochondria in the aetiology of insulin resistance and type 2 diabetes
S Martin, S McGee
(2014), Vol. 1840, pp. 1303-1312, Biochimica et biophysica acta, Amsterdam, The Netherlands, C1
K Vissing, S McGee, J Farup, T Kjolhede, M Vendelbo, N Jessen
(2013), Vol. 23, pp. 355-366, Scandinavian journal of medicine and science in sports, Malden, Mass., C1
A Walker, S Burnett, K Hasebe, J McGillivray, L Gray, S McGee, K Walder, M Berk, S Tye
(2013), Vol. 242, pp. 76-83, Behavioural brain research, Amsterdam, The Netherlands, C1
N Sadli, C Barrow, S McGee, C Suphioglu
(2013), Vol. 32, pp. 243-252, Cellular physiology and biochemistry, Berlin, Germany, C1
Metabolic profile analysis of zebrafish embryos
Y Gibert, S McGee, A Ward
(2013), Vol. 71, pp. 1-5, Journal of visualized experiments, Cambridge, Mass., C1
S Richter, S Morrison, T Connor, J Su, C Print, R Roniums, S McGee, W Wilson
(2013), Vol. 8, pp. 1-17, PLOS One, San Francisco, CA, C1
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
C Winbanks, J Chen, H Qian, Y Liu, B Bernardo, C Beyer, K Watt, R Thomson, T Connor, B Turner, J McMullen, L Larsson, S McGee, C Harrison, P Gregorevic
(2013), Vol. 203, pp. 345-357, The Journal of Cell Biology, New York, NY, C1
W Sanchez, S McGee, T Connor, B Mottram, A Wilkinson, J Whitehead, S Vuckovic, L Catley
(2013), Vol. 108, pp. 1624-1633, British journal of cancer, London, England, C1
Skeletal muscle fat metabolism after exercise in humans: influence of fat availability
N Kimber, D Cameron-Smith, S McGee, M Hargreaves
(2013), Vol. 114, pp. 1577-1585, Journal of Applied Physiology, Bethesda, Md., C1
M Fernandez-Rojo, M Gongora, R Fitzsimmons, N Martel, S Martin, S Nixon, A Brooks, M Ikonomopoulou, S Martin, H Lo, S Myers, C Restall, C Ferguson, P Pilch, S McGee, R Anderson, M Waters, J Hancock, S Grimmond, G Muscat, R Parton
(2013), Vol. 4, pp. 238-247, Cell Reports, Cambridge, MA, C1
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo
N Konstantopoulos, J Molero, S McGee, B Spolding, T Connor, M de Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, V Foletta, G Krippner, S Andrikopoulos, K Walder
(2012), Vol. 61, pp. 2146-2154, Diabetes, Alexandria, Va., C1
Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells
S Raichur, S Hooi-Teh, K Ohwaki, V Gaur, Y Long, M Hargreaves, S McGee, J Kusunoki
(2012), Vol. 49, pp. 203-211, Journal of molecular endocrinology, Bristol, England, C1
Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat
R Teperino, S Amann, M Bayer, S McGee, A Loipetzberger, T Connor, C Jaeger, B Kammerer, L Winter, G Wiche, K Dalgaard, M Selvaraj, M Gaster, R Lee-Young, M Febbraio, C Knauf, P Cani, F Aberger, J Penniger, J Pospisilik, H Esterbauer
(2012), Vol. 151, pp. 414-426, Cell, Cambridge, Mass., C1
M Fernandez-Rojo, C Restall, C Ferguson, N Martel, S Martin, M Bosch, A Kassan, G Leong, S Martin, S McGee, G Muscat, R Anderson, C Enrich, A Pol, R Parton
(2012), Vol. 55, pp. 1574-1584, Hepatology, Hoboken, N. J., C1
Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes
S Hussey, S McGee, A Garnham, G McConell, M Hargreaves
(2012), Vol. 14, pp. 768-771, Diabetes, obesity and metabolism, Oxford, England, C1
DHA protects against zinc mediated alterations in neuronal cellular bioenergetics
S McGee, N Sadli, S Morrison, C Swinton, C Suphioglu
(2011), Vol. 28, pp. 157-162, Cellular physiology and biochemistry, Basel, Switzerland, C1
Histone modifications and exercise adaptations
S McGee, M Hargreaves
(2011), Vol. 110, pp. 258-263, Journal of applied physiology, Bethesda, Md., C1
Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes
S Hussey, S McGee, A Garnham, J Wentworth, A Jeukendrup, M Hargreaves
(2011), Vol. 13, pp. 959-962, Diabetes, obesity and metabolism, West Sussex, England, C1-1
W Yeo, S McGee, A Carey, C Paton, A Garnham, M Hargreaves, J Hawley
(2010), Vol. 95, pp. 351-358, Experimental physiology, Oxford, England, C1
AMPK-mediated transcription in skeletal muscle
S McGee, M Hargreaves
(2010), Vol. 118, pp. 507-518, Clinical science, London, England, C1
Histone modifications and skeletal muscle metabolic gene expression
S McGee, M Hargreaves
(2010), Vol. 37, pp. 392-396, Clinical and experimental pharmacology and physiology, Richmond, Vic., C1
M Gibala, S McGee, A Garnham, K Howlett, R Snow, M Hargreaves
(2009), Vol. 106, pp. 929-934, Journal of applied physiology, Bethesda, Md., C1
Signalling GLUTtony keeps the sugar coming through glucose transporter expression
S McGee
(2009), Vol. 587, pp. 4133-4134, Journal of physiology, Oxford, England, C1
J Ryu, J Drain, J Kim, S McGee, A Gray-Weale, L Waddington, G Parker, M Hargreaves, S Yoo, D Stapleton
(2009), Vol. 45, pp. 478-482, International journal of biological macromolecules, Amsterdam, Netherlands, C1
Exercise-induced histone modifications in human skeletal muscle
S McGee, E Fairlie, A Garnham, M Hargreaves
(2009), Vol. 587, pp. 5951-5958, Journal of physiology, Oxford, England, C1
AMPK and transcriptional regulation
S McGee, M Hargreaves
(2008), Vol. 13, pp. 3022-3033, Frontiers in bioscience, Albertson, NY, C1-1
K Burgomaster, K Howarth, S Phillips, M Rakobowchuck, M MacDonald, S McGee, M Gibala
(2008), Vol. 586, pp. 151-160, Journal of physiology, Oxford, England, C1-1
Effect of sex differences on human MEF2 regulation during endurance exercise
K Vissing, S McGee, C Roepstorff, P Scherling, M Hargreaves, B Kiens
(2008), Vol. 294, pp. 408-415, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1-1
M Gibala, S McGee
(2008), Vol. 36, pp. 58-63, Exercise and sport sciences reviews, Philadelphia, Pa., C1-1
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
S McGee, B van Denderen, K Howlett, J Mollica, J Schertzer, B Kemp, M Hargreaves
(2008), Vol. 57, pp. 860-867, Diabetes, Alexandria, Va., C1-1
S McGee, K Mustard, D Hardie, K Baar
(2008), Vol. 586, pp. 1731-1741, Journal of physiology, Oxford, England, C1-1
Optimizing training adaptations by manipulating glycogen
K Baar, S McGee
(2008), Vol. 8, pp. 97-106, European journal of sport science, Abingdon, England, C1-1
H Boon, M Bosselaar, S Praet, E Blaak, W Saris, A Wagenmakers, S McGee, C Tack, P Smits, M Hargreaves, L van Loon
(2008), Vol. 51, pp. 1893-1900, Diabetologia, Heidelberg, Germany, C1-1
Exercise and MEF2-HDAC interactions.
S McGee
(2007), Vol. 32, pp. 852-856, Applied physiology, nutrition and metabolism, Ottawa, Ontario, C1-1
Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle
S McGee, D Sparling, A Olson, M Hargreaves
(2006), Vol. 20, pp. 348-349, FASEB journal, Bethesada, Md., C1-1
Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms
S McGee, M Hargreaves
(2006), Vol. 33, pp. 395-399, Clinical and experimental pharmacology and physiology, Richmond, Vic., C1-1
G Steinberg, M Watt, S McGee, S Chan, M Hargreaves, M Febbraio, D Stapleton, B Kemp
(2006), Vol. 31, pp. 302-312, Applied physiology, nutrition, and metabolism, Ottawa, Ont., C1-1
Effect of carbohydrate ingestion on exercise-induced alterations in metabolic gene expression
L Cluberton, S McGee, R Murphy, M Hargreaves
(2005), Vol. 99, pp. 1359-1363, Journal of applied physiology, [Bethesda, Md.], C1-1
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle
S McGee, M Hargreaves
(2004), Vol. 53, pp. 1208-1214, Diabetes, New York, N.Y., C1
M Chan, S McGee, M Watt, M Hargreaves, M Febbraio
(2004), Vol. September, pp. 1-16, FASEB Journal, Bethesda, MD, C1
Exercise increases nuclear AMPK α2 in human skeletal muscle
S McGee, K Howlett, R Starkie, D Cameron-Smith, B Kemp, M Hargreaves
(2003), Vol. 52, pp. 926-928, Diabetes, Alexandria, Va., C1
Funded Projects at Deakin
Australian Competitive Grants
HDAC inhibition as an exercise mimetic and treatment for obesity and type 2 diabetes
Prof Sean Mcgee
DART Fellowship - Viertel Postdoctoral Fellowship in Diabetes - Diabetes Australia - Victoria (Research Trust)
- 2011: $75,000
- 2010: $150,000
- 2009: $75,000
Molecular mechanisms regulating contraction-induced metabolic gene expression
Prof Sean Mcgee
NHMRC - Training PD Award - Peter Doherty Fellowship
- 2009: $71,250
Activation of HSP72 in skeletal muscle as a therapeutic target for obesity
Prof Mark Febbraio, Prof Clinton Bruce, Prof Sean Mcgee, Prof Mark Hargreaves
NHMRC Project Grant
- 2013: $20,000
- 2012: $20,000
The role of amyloid beta in insulin resistance
Prof Sean Mcgee, Prof Ken Walder, Prof Mark Hargreaves
NHMRC Project Grant
- 2014: $125,826
- 2013: $138,472
- 2012: $136,023
Understanding the role of class IIa histone deacetylases in metabolic disease
Prof Sean Mcgee, Prof Ken Walder
NHMRC Project Grant
- 2014: $164,086
- 2013: $161,714
- 2012: $143,600
Targeting the class IIa histone deacetylases in metabolic disease
Prof Sean Mcgee
NHMRC CDF - Career Development Fellowship
- 2015: $104,794
- 2014: $102,941
- 2013: $101,220
- 2012: $99,431
Transforming fat to increase energy expenditure
Prof Sean Mcgee
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2013: $59,312
Targeting protein kinase D to treat diabetic cardiomyopathy
Prof Sean Mcgee, Dr Kylie Vernados
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2015: $58,592
Targeting class IIa histone deacetylases to impair breast cancer cell metabolism and survival
Prof Sean Mcgee
National Breast Cancer Foundation Innovator Grant
- 2016: $97,690
- 2015: $98,690
The role of GAPDH acetylation in the regulation of liver metabolism
Prof Sean Mcgee
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2016: $59,983
The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes
Prof Sean Mcgee, Prof Clinton Bruce, Prof Forest White, Prof Ken Walder
NHMRC Project Grant
- 2020: $10,462
- 2019: $187,097
- 2018: $181,879
- 2017: $169,227
The role of the Alzheimer's disease protein amyloid beta 42 in diabetic cardiomyopathy
Prof Sean Mcgee, Prof Clinton Bruce
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2017: $59,962
Role of protein kinase D in adiposity and the regulation of body weight
Prof Sean Mcgee, A/Prof Zane Andrews, Prof David James
NHMRC Project Grant
- 2021: $102,831
- 2020: $94,687
- 2019: $181,854
A novel approach to target beta-cells to enhance survival and function
A/Prof Kathryn Aston-Mourney, A/Prof Sarah Shigdar, Prof Sean Mcgee
DART Grant - Research - Diabetes Australia - Victoria (Research Trust)
- 2020: $59,756
Using 'omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS
Prof Ken Walder, Prof Michael Berk, Dr Chiara Bortolasci, Prof Sean Mcgee, Prof Clinton Bruce, Dr Wolf Marx
NHMRC Targeted Call for Research into Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Grant Opportunity
- 2023: $187,707
- 2022: $164,314
- 2021: $152,361
- 2020: $25,320
Fasting hyperinsulinemia remodels adipose tissue metabolism to drive obesity and insulin resistance
Dr Chris Shaw, Prof Clinton Bruce, Dr Kirsten Howlett, Prof Sean Mcgee, Dr Greg Kowalski
Diabetes Australia Research Program Grant
- 2021: $59,895
Other Public Sector Funding
Development of new exercise mimetics for better treatment of metabolic and heart diseases
Prof Sean Mcgee
DHHS - Victorian Medical Research Acceleration Fund
- 2019: $100,000
Industry and Other Funding
Proliferation and cell cycle arrest by AMP-activated protein kinase and histone deacetylase 5
Prof Sean Mcgee
ANZCT Grant - Medical Research and Technology
- 2009: $9,370
Mechanistically linking type 2 diabetes and Alzheimer's disease
Prof Sean Mcgee
Clive and Vera Ramaciotti Foundation Grant - Research
- 2012: $74,290
HDAC Inhibition as a Potential Therapy for Preventing the Progression of Type 2 Diabetes
A/Prof Kathryn Aston-Mourney, Prof Sean Mcgee
CASS Grant - Research - The CASS Foundation Limited
- 2015: $55,000
Identifying the role of altered mitochondrial metabolism in malignant rhabdoid tumours and evaluating potential epigenetic therapies
Prof David Ashley, Prof Sean Mcgee, Dr Jason Cain
Sarcoma Research Grants
- 2016: $23,000
Development of new exercise mimetics for better treatment of metabolic and heart diseases
Prof Sean Mcgee
Imitex Pty Ltd
- 2020: $60,000
- 2019: $40,000
New therapies for obesity-induced heart disease.
Prof Sean Mcgee
Ambetex Pty Ltd
- 2020: $83,216
Clinical biomarker shoulder study: transcriptomic differences between osteoarthritis of the shoulder, capsulitis and rotator cuff tears
Prof Richard Page, Dr Stephen Gill, Prof Sean Mcgee
Australian Orthopaedic Association Research Foundation
- 2021: $50,000
Biomarkers of negative symptoms, cognitive impairment and metabolic abnormalities in schizophrenia
Prof Alison Yung, Prof Sean Mcgee, Dr Luba Sominsky, Prof Ken Walder, Prof Julie Pasco, Prof Lana Williams, Dr Steve Moylan, Dr Mohammadreza Mohebbi, Dr Zoe Liu, Mr Marko Milicevic, Mr Wesley Plange
Royal Australian and New Zealand College of Psychiatrists Foundation Catalyst Grants
- 2022: $4,980
Clinical Biomarker Shoulder Study: Transcriptomic differences between inflammatory conditions of the shoulder: osteoarthritis and rotator cuff tears -The SHOaW Study.
Dr Samuel James Lynskey, Prof Richard Page, Dr Stephen Gill, Prof Sean Mcgee, Dr Mark Ziemann, Dr Luba Sominsky
Australian Orthopaedic Association Research Foundation
- 2023: $10,000
Supervisions
Liam Hall
Thesis entitled: The Role of Amyloid Beta 42 in Obese Cardiomyopathy
Doctor of Philosophy (Medicine), School of Medicine
Joshua Blair Price
Thesis entitled: Investigating Mechanisms of Stress, Inflammation, and Bioenergetics in Treatment-resistant Depression
Doctor of Philosophy (Medicine), School of Medicine
Juliane Czeczor
Thesis entitled: Functional Role of Amyloid b42 in Systemic Glucose Metabolism
Doctor of Philosophy (Medicine), School of Medicine
Kirstie Anne De Jong
Thesis entitled: Characterisation of the Obese and T2D Heart - Protein Kinase D, a Possible Therapeutic Target
Doctor of Philosophy (Medicine), School of Medicine
Simon Bond
Thesis entitled: The Role of Glyceraldehyde-3-Phosphate Dehydrogenase Acetylation in Liver Metabolism
Doctor of Philosophy (Medicine), School of Medicine
Vidhi Gaur
Thesis entitled: HDAC inhibition as a therapeutic potential to treat metabolic diseases
Doctor of Philosophy (Medicine), School of Medicine
Mark Renton
Thesis entitled: The role of protein kinase D in obesity
Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences
Bianca Tepper
Thesis entitled: Extracellular Matrix Remodelling: Role in Insulin Resistance and Exercise Adaptations
Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences
Elley Rudebeck
Thesis entitled: Mono- and di-substituted 1,8-naphthalimides for cellular imaging and medicinal chemistry
Doctor of Philosophy (Life & Env), School of Life and Environmental Sciences
Wasan Abbood Hassoon Naser
Thesis entitled: Role of cytokine-inducible Src homology domain 2-containing protein in myelopoiesis and metabolic regulation
Doctor of Philosophy (Medicine), School of Medicine
Caitlin Murphy
Thesis entitled: Clinical and Molecular Outcomes of a Neo-adjuvant Breast Cancer Trial
MAppSc (Medicine) (High cost), School of Medicine
Shahzad Sadiq
Thesis entitled: Evaluating the Role of Novel microRNAs in Cardiac Hypertrophy
Doctor of Philosophy (Medicine), School of Medicine
Corinna Pade
Thesis entitled: Dissecting the early entry steps of HIV-1 infection
Doctor of Philosophy (Medicine), School of Medicine
Sivapriya Pavuluri
Thesis entitled: Genomics based biomarker discovery in oral squamous cell carcinoma
Doctor of Philosophy (Medicine), School of Medicine