Dr Severine Lamon

STAFF PROFILE

Position

Senior Lecturer, Nutrition and Exercise Physiology

Faculty

Faculty of Health

Department

School of Exercise & Nut. Sci.

Campus

Melbourne Burwood Campus

Qualifications

Doctor in Life Sciences, , 2010

Contact

Biography

I was awarded my PhD from Lausanne University, Switzerland, in 2010. I then completed all my post-doctoral training in Australia and I am currently a Senior Lecturer within the School of Exercise and Nutrition Sciences. I am a molecular biologist by training, and my main research focus is the regulation of skeletal muscle mass with health and disease. I have a particular interest in the role played by non-coding RNAs in the regulation of these processes. I have recently developed a new research program focusing on female muscle physiology, and how the female muscle adapts to exercise and disease conditions at the epigenetic, molecular, cellular and functional level. 

Read more on Severine's profile

Biography summary

2018-current: Senior Lecturer –  School of Exercise and Nutrition Sciences

2020: Faculty of Health Mid-Career Research Fellow - Institute for Physical Activity and Nutrition Research (IPAN), School of Exercise and Nutrition Sciences

2015-2017: Australian Research Council (ARC) Discovery Early Career Research Fellow – Institute for Physical Activity and Nutrition Research (IPAN), School of Exercise and Nutrition Sciences

2012-2014: Alfred Deakin Post-Doctoral Research Fellow – Centre of Physical Activity and Nutrition Research (C-PAN), School of Exercise and Nutrition Sciences

2010-2012: Swiss National Science Foundation Early Career Research Fellow – Centre of Physical Activity and Nutrition Research (C-PAN), School of Exercise and Nutrition Sciences

Career highlights

In 2008, I developed an original anti-doping test against the 3rd generation erythropoietin (EPO) molecule (Continuous EPO Receptor Activator, CERA) that was commercialized by Roche Pharmaceuticals and used worldwide (MicroCoat® MIRCERA ELISA, Microcoat Biotechnologies GMBH, PMID19625154).

Research interests

Muscle physiology; Exercise physiology; Cell biology; Non-coding RNAs; Epigenetics 

Affiliations

Australian Physiological Society (AuPS)

Teaching interests

Human physiology; Muscle physiology; Muscle biology; Biochemistry

Units taught

HSN749: Biochemistry and Physiology for Human Nutrition (2017-2019)

HSE110: Muscle Biology for Exercise Sciences (2019)

Knowledge areas

Muscle physiology; cell biology; non-coding RNAs; female physiology; anti-doping

Conferences

Invited conference presentations (selected):

  • Exercise, Muscle and Metabolism Conference - Melbourne, Australia (2019) - Breaking through the assumption: Breaking through the assumptions: the role of testosterone in female muscle adaptation to exercise
  • Non-coding RNA in Metabolic Diseases Symposium – Copenhagen, Denmark (2019) - Mitochondrial non-coding RNAs as new regulators of skeletal muscle function?
  • Australasian Society of Diagnostic Genomics (ASDG) SIG Meeting – Brisbane, Australia (2017) - New biomarkers of ageing in human skeletal muscle 
  • Gage Muscle Conference - Canberra, Australia (2016) - Investigating the role of microRNAs in skeletal muscle growth/ageing and associated challenges

Professional activities

  • Australian Physiological Society (AuPS) treasurer (2019-2021)
  • Australian Physiological Society (AuPS) membership officer (2016-2018)

Awards

  • 2020 Faculty of Health Mid-Career Research Fellowship (Deakin University)
  • 2019 Fellow of the Higher Education Academy (FHEA)
  • 2018 Experimental Physiology Inaugural Review Prize (The Physiological Society)
  • 2016 Victorian Fellowship (Victoria Government, Minister for Small Business, Innovation and Trade)
  • 2015 ARC Discovery Early Career Research Fellowship (Australian Research Council)
  • 2015 Vice-Chancellor’s Early Career Researcher Award for Research Excellence (Deakin University)
  • 2012 Alfred Deakin Post-Doctoral Research Fellowship (Deakin University)
  • 2010 SNSF Early Career Research Fellowship (Swiss National Science Foundation)
  • 2007 Swiss Interfaculty Conference of Sport and Health, Best oral presentation

Projects

  • Can exercise slow down the epigenetic ageing clock?” - ARC Discovery Project (Eynon N, Voisin S, Lamon S, Levinger I), 2020-2022
  • Does endogenous testosterone determine athletic performance in females?” - International Olympic Committee Medical and Scientific Research Fund (Lamon S), 2021-2022
  • "The effect of an obesogenic maternal environment on mouse growth patterns, satellite cell activation and markers of post-natal myogenesis" (Lamon S and Mikovic J), 2016-2020
  • "The effect of sleep deprivation on muscle protein metabolism" (Lamon S and Aisbett B), 2016-2020
  • Understanding the role of miRNAs in the biology of ageing muscle” - ARC Discovery Early Career Researcher Award (Lamon S), 2015-2017

Publications

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2020

Countering disuse atrophy in older adults with low-volume leucine supplementation

Emily Arentson-Lantz, Kinga Fiebig, Kim Anderson-Catania, Rachel Deer, Adam Wacher, Christopher Fry, Severine Lamon, Douglas Paddon-Jones

(2020), Vol. 128, pp. 967-977, Journal of applied physiology, [Bethesda, Md.], C1

journal article

Extracellular vesicular miRNA expression is not a proxy for skeletal muscle miRNA expression in males and females following acute, moderate intensity exercise

J Silver, S Alexander, H Dillon, S Lamon, G Wadley

(2020), Vol. 8, pp. 1-15, Physiological reports, Chichester, Eng., C1

journal article
2019

Non-coding RNAs regulating cardiac muscle mass

Glenn Wadley, Séverine Lamon, Sarah Alexander, Julie McMullen, Bianca Bernardo

(2019), Vol. 127, pp. 633-644, Journal of applied physiology, Bethesda, Md., C1

journal article

Genetic and epigenetic sex-specific adaptations to endurance exercise

Shanie Landen, Sarah Voisin, Jeffrey Craig, Sean McGee, Séverine Lamon, Nir Eynon

(2019), Vol. 14, pp. 523-535, Epigenetics, Abingdon, Eng., C1

journal article

Resistance training and skeletal muscle protein metabolism in eumenorrheic females: implications for researchers and practitioners

O Knowles, B Aisbett, L Main, E Drinkwater, L Orellana, S Lamon

(2019), Vol. 49, pp. 1637-1650, Sports medicine, Cham, Switzerland, C1

journal article

Identifying and assessing inter-muscular fat at the distal diaphyseal femur measured by peripheral quantitative computed tomography (pQCT)

P Owen, N Hart, C Latella, A Hendy, S Lamon, T Rantalainen

(2019), pp. 1-6, Journal of clinical densitometry, Amsterdam, The Netherlands, C1

journal article
2018

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice

A Russell, L Ghobrial, S Ngo, J Yerbury, E Zacharewicz, R Chung, S Lamon

(2018), Vol. 57, pp. 838-847, Muscle and nerve, Chichester, Eng., C1

journal article

Inadequate sleep and muscle strength: implications for resistance training

Olivia Knowles, Eric Drinkwater, Charles Urwin, Séverine Lamon, Brad Aisbett

(2018), Vol. 21, pp. 959-968, Journal of science and medicine in sport, Amsterdam, The Netherlands, C1

journal article

Mitochondrial regulation in skeletal muscle: a role for non-coding RNAs?

Jessica Silver, Glenn Wadley, Séverine Lamon

(2018), Vol. 103, pp. 1132-1144, Experimental physiology, Chichester, Eng., C1

journal article

Recent advances in understanding the role of FOXO3

Renae Stefanetti, Sarah Voisin, Aaron Russell, Séverine Lamon

(2018), Vol. 7, pp. 1-8, F1000Research, London, Eng., C1

journal article

The reliability of neurological measurement in the vastus medialis: implications for research and practice

Hans Leung, Christopher Latella, Séverine Lamon, Ashlee Hendy

(2018), Vol. 9, pp. 1-10, Frontiers in psychology: movement science and sport psychology, Lausanne, Switzerland, C1

journal article

MicroRNA and long non-coding RNA regulation in skeletal muscle from growth to old age shows striking dysregulation of the callipyge locus

Jasmine Mikovic, Kate Sadler, Lauren Butchart, Sarah Voisin, Frederico Gerlinger-Romero, Paul Della Gatta, Miranda Grounds, Severine Lamon

(2018), Vol. 9, pp. 1-12, Frontiers in genetics, Lausanne, Switzerland, C1

journal article
2017

The role and regulation of PGC-1α and PGC-1β in skeletal muscle adaptation

S Lamon, A Russell

(2017), pp. 179-194, The plasticity of skeletal muscle: from molecular mechanism to clinical applications, Singapore, B1-1

book chapter

Striated muscle activator of Rho signalling (STARS) is reduced in ageing human skeletal muscle and targeted by miR-628-5p

A Russell, M Wallace, M Kalanon, E Zacharewicz, P Della Gatta, A Garnham, S Lamon

(2017), Vol. 220, pp. 263-274, Acta physiologica, London, Eng., C1

journal article

MicroRNA expression patterns in post-natal mouse skeletal muscle development

S Lamon, E Zacharewicz, L Butchart, L Orellana, J Mikovic, M Grounds, A Russell

(2017), Vol. 18, pp. 1-13, BMC genomics, London, Eng., C1

journal article

The impact of shiftwork on skeletal muscle health

B Aisbett, D Condo, E Zacharewicz, S Lamon

(2017), Vol. 9, pp. 1-16, Nutrients, Basel, Switzerland, C1

journal article

Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity

S Pinto, S Lamon, E Stephenson, M Kalanon, J Mikovic, L Koch, S Britton, J Hawley, D Camera

(2017), Vol. 313, pp. E335-E343, American journal of physiology, endocrinology and metabolism, Bethesda, Md., C1

journal article

The cross-education phenomenon: brain and beyond

A Hendy, S Lamon

(2017), Vol. 8, Frontiers in physiology, Lausanne, Switzerland, C1

journal article
2016

Overexpression of striated muscle activator of Rho signaling (STARS) increases C2C12 skeletal muscle cell differentiation

M Wallace, P Della Gatta, B Mir, G Kowalski, J Kloehn, M McConville, A Russell, S Lamon

(2016), Vol. 7, pp. 1-13, Frontiers in physiology, Lausanne, Switzerland, C1

journal article

Protecting skeletal muscle with protein and amino acid during periods of disuse

E Galvan, E Arentson-Lantz, S Lamon, D Paddon-Jones

(2016), Vol. 8, pp. 1-11, Nutrients, Basel, Switzerland, C1

journal article

Erythropoietin does not enhance skeletal muscle protein synthesis following exercise in young and older adults

S Lamon, E Zacharewicz, E Arentson-Lantz, P Della Gatta, L Ghobrial, F Gerlinger Romero, A Garnham, D Paddon-Jones, A Russell

(2016), Vol. 7, pp. 1-8, Frontiers in physiology, Lausanne, Switzerland, C1

journal article
2015

Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training

R Stefanetti, S Lamon, M Wallace, M Vendelbo, A Russell, K Vissing

(2015), Vol. 467, pp. 1523-1537, Pflugers archiv - European journal of physiology, Berlin, Germany, C1

journal article

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet

Greg Kowalski, Joachim Kloehn, Micah Burch, Ahrathy Selathurai, Steven Hamley, Stéphanie Bayol, Séverine Lamon, Matthew Watt, Robert Lee-Young, Malcolm McConville, C Bruce

(2015), Vol. 1851, pp. 210-219, Biochimica et Biophysica Acta (BBA)- molecular and cell biology of lipids, Amsterdam, Netherlands, C1

journal article

Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training

G Vincent, S Lamon, N Gant, P Vincent, J MacDonald, J Markworth, J Edge, A Hickey

(2015), Vol. 6, pp. 1-8, Frontiers in Physiology, Lausanne, Switzerland, C1

journal article

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A Selathurai, G Kowalski, M Burch, P Sepulveda, S Risis, R Lee-Young, S Lamon, P Meikle, A Genders, S McGee, M Watt, A Russell, M Frank, S Jackowski, M Febbraio, C Bruce

(2015), Vol. 21, pp. 718-730, Cell Metabolism, United States, C1

journal article

Exercise, skeletal muscle and circulating microRNAs

A Russell, S Lamon

(2015), Vol. 135, pp. 471-496, Progress in molecular biology and translational science, Amsterdam, The Netherlands, C1

journal article

Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans

D Morrison, J Hughes, P Della Gatta, S Mason, S Lamon, A Russell, G Wadley

(2015), Vol. 89, pp. 852-862, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal article

Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy

P Sepulveda, S Lamon, A Hagg, R Thomson, C Winbanks, H Qian, C Bruce, A Russell, P Gregorevic

(2015), Vol. 5, pp. 1-11, Scientific reports, London, Eng., C1

journal article
2014

Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.

A Russell, L Ghobrial, C Wright, S Lamon, E Brown, M Kon, M Skelton, R Snow

(2014), Vol. 5, pp. 1-6, Frontiers in physiology, Lausanne, Switzerland, C1

journal article

Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise.

R Stefanetti, E Zacharewicz, P Della Gatta, A Garnham, A Russell, S Lamon

(2014), Vol. 5, pp. 1-10, Frontiers in Physiology, Lausanne, Switzerland, C1

journal article

The STARS signaling pathway: a key regulator of skeletal muscle function

S Lamon, M Wallace, A Russell

(2014), Vol. 466, pp. 1659-1671, Pflügers archiv - European journal of physiology, Heidelberg, Germany, C1

journal article

EPO-receptor is present in mouse C2C12 and human primary skeletal muscle cells but EPO does not influence myogenesis

S Lamon, E Zacharewicz, A Stephens, A Russell

(2014), Vol. 2, pp. 1-22, Physiological reports, Oxford, England, C1

journal article

Influence of divergent exercise contraction mode and whey protein supplementation on atrogin-1, MuRF1, and FOXO1/3A in human skeletal muscle

R Stefanetti, S Lamon, S Rahbek, J Farup, E Zacharewicz, M Wallace, M Vendelbo, A Russell, K Vissing

(2014), Vol. 116, pp. 1491-1502, Journal of applied physiology, Bethesda, MD, C1

journal article

Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy

J Church, J Trieu, A Chee, T Naim, S Gehrig, S Lamon, C Angelini, A Russell, G Lynch

(2014), Vol. 99, pp. 675-687, Experimental physiology, Chichester, England, C1

journal article

Androgenic and estrogenic regulation of Atrogin-1, MuRF1 and myostatin expression in different muscle types of male mice

H De Naeyer, S Lamon, A Russell, I Everaert, A De Spaey, B Vanheel, Y Taes, W Derave

(2014), Vol. 114, pp. 751-761, European journal of applied physiology, heidelberg, Germany, C1

journal article

Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle

E Zacharewicz, P Della Gatta, J Reynolds, A Garnham, T Crowley, A Russell, S Lamon

(2014), Vol. 9, pp. 1-25, PLoS One, San Francisco, Calif., C1

journal article

Validation of a multiplex reverse transcription and pre-amplification method using TaqMan(®) MicroRNA assays.

J Le Carré, S Lamon, B Léger

(2014), Vol. 5, pp. 413-1, Frontiers in genetics, Lausanne, Switzerland, C1

journal article
2013

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

A Russell, S Wada, L Vergani, M Hock, S Lamon, B Léger, T Ushida, R Cartoni, G Wadley, P Hespel, A Kralli, G Soraru, C Angelini, T Akimoto

(2013), Vol. 49, pp. 107-117, Neurobiology of Disease, C1

journal article

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training

A Russell, A Russell, S Lamon, S Lamon, H Boon, H Boon, S Wada, S Wada, I Güller, I Güller, E Brown, E Brown, A Chibalin, A Chibalin, J Zierath, J Zierath, R Snow, R Snow, N Stepto, N Stepto, G Wadley, G Wadley, T Akimoto, T Akimoto

(2013), Vol. 591, pp. 4637-4653, Journal of Physiology, C1-1

journal article

The role and regulation of erythropoietin (EPO) and its receptor in skeletal muscle: how much do we really know?

S Lamon, A Russell

(2013), Vol. 4, pp. 1-9, Frontiers in physiology, Lausanne, Switzerland, C1-1

journal article

MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease

E Zacharewicz, S Lamon, A Russell

(2013), Vol. 4, pp. 1-11, Frontiers in physiology, Lausanne, Switzerland, C1-1

journal article

Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training

S Lamon, M Wallace, R Stefanetti, S Rahbek, M Vendelbo, A Russell, K Vissing

(2013), Vol. 465, pp. 1317-1325, Pfluegers Archiv: European journal of physiology, Berlin, Germany, C1-1

journal article

Effect of resistance exercise contraction mode and protein supplementation on members of the STARS signalling pathway

K Vissing, S Rahbek, S Lamon, J Farup, R Stefanetti, M Wallace, M Vendelbo, A Russell

(2013), Vol. 591, pp. 3749-3763, Journal of physiology, London, Eng., C1-1

journal article
2012

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

S Gehrig, C Van Der Poel, T Sayer, J Schertzer, D Henstridge, J Church, S Lamon, A Russell, K Davies, M Febbraio, G Lynch

(2012), Vol. 484, pp. 394-398, Nature, C1

journal article

The regulation and function of the striated muscle activator of rho signaling (STARS) protein

M Wallace, S Lamon, A Russell

(2012), Vol. 3, pp. 1-5, Frontiers in physiology, Lausanne, Switzerland, C1

journal article
2011

Direct Methods for Distinction Between Endogenous and Exogenous Erythropoietin

Séverine Lamon, Neil Robinson, Martial Saugy

(2011), pp. 163-175, Hormone Use and Abuse by Athletes, B1-1

book chapter

How to confirm C.E.R.A. doping in athletes' blood?

N Leuenberger, S Lamon, N Robinson, S Giraud, M Saugy

(2011), Vol. 213, pp. 101-103, Forensic Science International, C1-1

journal article
2010

Erythropoietin (EPO) immunoaffinity columns-A powerful tool for purifying EPO and its recombinant analogues

Y Dehnes, S Lamon, M Lönnberg

(2010), Vol. 53, pp. 1028-1032, Journal of Pharmaceutical and Biomedical Analysis, C1-1

journal article

IEF pattern classification-derived criteria for the identification of epoetin-δ in urine

S Lamon, J Boccard, P Sottas, N Glatz, G Wuerzner, N Robinson, M Saugy

(2010), Vol. 31, pp. 1918-1924, Electrophoresis, C1-1

journal article

Procedures for Monitoring Recombinant Erythropoietin and Analogs in Doping

S Lamon, N Robinson, M Saugy

(2010), Vol. 39, pp. 141-154, Endocrinology and Metabolism Clinics of North America, C1-1

journal article

Rapid affinity purification of erythropoietin from biological samples using disposable monoliths

M Lönnberg, Y Dehnes, M Drevin, M Garle, S Lamon, N Leuenberger, T Quach, J Carlsson

(2010), Vol. 1217, pp. 7031-7037, Journal of Chromatography A, C1-1

journal article
2009

Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy

S Lamon, M Wallace, B Léger, A Russell

(2009), Vol. 587, pp. 1795-1803, Journal of Physiology, C1

journal article

A high-throughput test to detect C.E.R.A. doping in blood

S Lamon, S Giraud, L Egli, J Smolander, M Jarsch, K Stubenrauch, A Hellwig, M Saugy, N Robinson

(2009), Vol. 50, pp. 954-958, Journal of Pharmaceutical and Biomedical Analysis, C1-1

journal article

Effects of exercise on the isoelectric patterns of erythropoietin

S Lamon, L Martin, N Robinson, M Saugy, J Ceaurriz, F Lasne

(2009), Vol. 19, pp. 311-315, Clinical Journal of Sport Medicine, C1-1

journal article
2007

Detection window of Darbepoetin-α following one single subcutaneous injection

S Lamon, N Robinson, P Mangin, M Saugy

(2007), Vol. 379, pp. 145-149, Clinica Chimica Acta, C1-1

journal article

Possible origins of undetectable EPO in urine samples

S Lamon, N Robinson, P Sottas, H Henry, M Kamber, P Mangin, M Saugy

(2007), Vol. 385, pp. 61-66, Clinica Chimica Acta, C1-1

journal article
2006

Akt signalling through GSK-3β, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy

B Léger, R Cartoni, M Praz, S Lamon, O Dériaz, A Crettenand, C Gobelet, P Rohmer, M Konzelmann, F Luthi, A Russell

(2006), Vol. 576, pp. 923-933, Journal of Physiology, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Understanding the role of miRNAs in the biology of ageing muscle

Dr Severine Lamon

ARC DECRA - Discovery Early Career Researcher Award

  • 2017: $119,784
  • 2016: $115,944
  • 2015: $118,079

Can exercise slow down the epigenetic ageing clock?

Dr Nir Eynon, Dr Sarah Voisin, Dr Severine Lamon, Dr Itamar Levinger

ARC - Discovery Projects

  • 2020: $66,000

Other Public Sector Funding

Targeting site specific improvements of clinical trial operational processes.

Dr Severine Lamon, Ms Jasmine Mikovic

  • 2020: $43,169

Industry and Other Funding

Targeting site specific improvements of clinical trial operational processes.

Dr Severine Lamon, Ms Jasmine Mikovic

  • 2020: $1,573

Supervisions

Associate Supervisor
2020

Kate Sadler

Thesis entitled: Establishing the role of Striated Muscle Activator of Rho Signalling

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2016

Evelyn Zacharewicz

Thesis entitled: The Role of MicroRNAs in Regulating Muscle Protein Synthesis

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2014

Renae Stefanetti

Thesis entitled: Atrogin-1 and MURF-1 signalling in human skeletal muscle

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences