A/Prof. Tamsyn Crowley

STAFF PROFILE

Position

Associate Professor in Medical Bioinformatics

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Doctor of Philosophy, Deakin University, 2007

Contact

Biography

Dr Crowley began her scientific career at RMIT University followed by completing her PhD at Deakin University in 2004. She then moved to CSIRO's AAHL where she spent 12 years working on projects focused on agriculture. During her time at AAHL she had the opportunity to develop her bioinformatic capabilities. In the later part of the CSIRO position she also established links with Deakin through a joint Bioinformatics position. Recently (2016) Dr Crowley has joined the School of Medicine as an academic staff member teaching in the areas of Pharmacology and Therapeutic development. Dr Crowley Is also the founder of Deakin's Bioinformatic Core Research Facility.

Read more on Tamsyn's profile

Research interests

Bioinformatics, biomarkers, microRNA, NGS, Pigeon milk

Teaching interests

Bioinformatics, Pharmacology, Therapeutic development

Units taught

HMM301, HMM304

Knowledge areas

Bioinformatics, pharmacology, therapeutics and cellular biology.

Projects

  1. Biomarkers in poultry welfare
  2. Biomarkers for animal production
  3. Is the pigeon crop the avian mammary gland?
  4. Identifying novel signalling factors in breast milk: do they play a role in food sensitisation?

Publications

Filter by

2019

Solving for X: evidence for sex-specific autism biomarkers across multiple transcriptomic studies

Samuel Lee, Thomas Quinn, Jerry Lai, Sek Kong, Irva Hertz-Picciotto, Stephen Glatt, Tamsyn Crowley, Svetha Venkatesh, Thin Nguyen

(2019), Vol. 180, pp. 337-389, American journal of medical genetics: part B neuropsychiatric genetics, Chichester, Eng., C1

journal

Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

K Hasebe, L Rivera, C Smith, T Allnutt, T Crowley, T Nelson, O Dean, S McGee, K Walder, L Gray

(2019), Vol. 82, pp. 309-318, Brain, behavior, and immunity, Amsterdam, The Netherlands, C1

journal

A field guide for the compositional analysis of any-omics data

T Quinn, I Erb, G Gloor, C Notredame, M Richardson, T Crowley

(2019), Vol. 8, pp. 1-14, GigaScience, Oxford, Eng., C1

journal
2018

Understanding sequencing data as compositions: an outlook and review

Thomas Quinn, Ionas Erb, Mark Richardson, Tamsyn Crowley

(2018), Vol. 34, pp. 2870-2878, Bioinformatics, London, Eng., C1

journal

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

Srisaiyini Kidnapillai, Chiara Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia Dean, Tamsyn Crowley, Stphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk, Ken Walder

(2018), pp. 1-9, World journal of biological psychiatry, London, Eng., C1

journal

Benchmarking differential expression analysis tools for RNA-Seq: normalization-based vs. log-ratio transformation-based methods

Thomas Quinn, Tamsyn Crowley, Mark Richardson

(2018), Vol. 19, BMC bioinformatics, London, Eng., C1

journal
2017

Gene expression signature: a powerful approach for drug discovery in diabetes

S Sithara, T Crowley, K Walder, K Aston-Mourney

(2017), Vol. 232, pp. R131-R139, Journal of endocrinology, Bristol, Eng., C1

journal

Mapping genotype-phenotype associations of nsSNPs in coiled-coil oligomerization domains of the human proteome

K Mohanasundaram, M Grover, T Crowley, A Goscinski, M Wouters

(2017), Vol. 38, pp. 1378-1393, Human mutation, Chichester, Eng., C1

journal

Microbiota of little penguins and short-tailed shearwaters during development

M Dewar, J Arnould, T Allnutt, T Crowley, L Krause, J Reynolds, P Dann, S Smith

(2017), Vol. 12, pp. 1-16, Plos one, San Francisco, Calif., C1

journal

Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes

J Kumar, H Fang, D McCulloch, T Crowley, A Ward

(2017), Vol. 8, pp. 93530-93540, Oncotarget, Albany, N.Y., C1

journal

propr: An R-package for identifying proportionally abundant features using compositional data analysis

T Quinn, M Richardson, D Lovell, T Crowley

(2017), Vol. 7, Scientific Reports, London, Eng., C1

journal

Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats

S Barrand, T Crowley, R Wood-Bradley, K De Jong, J Armitage

(2017), Vol. 12, pp. 1-16, PLoS one, San Francisco, Calif., C1

journal
2016

Selection on mitochondrial variants occurs between and within individuals in an expanding invasion

L Rollins, A Woolnough, B Fanson, M Cummins, T Crowley, A Wilton, R Sinclair, A Butler, W Sherwin

(2016), Vol. 33, pp. 995-1007, Molecular biology and evolution, Oxford, Eng., C1

journal

Clinico-pathological association of delineated miRNAs in uveal melanoma with monosomy 3/Disomy 3 chromosomal aberrations

N Venkatesan, J Kanwar, P Deepa, V Khetan, T Crowley, R Raguraman, G Sugneswari, P Rishi, V Natarajan, J Biswas, S Krishnakumar

(2016), Vol. 11, pp. 1-14, PLoS one, San Francisco, Calif., C1

journal

Isolation and detection of microRNA from the egg of chickens

B Wade, M Cummins, A Keyburn, T Crowley

(2016), Vol. 9, pp. 1-6, BMC research notes, London, Eng., C1

journal

MicroRNAs in a hypertrophic heart: from foetal life to adulthood

S Sadiq, T Crowley, F Charchar, A Sanigorski, P Lewandowski

(2016), pp. 1-18, Biological reviews : Cambridge philosophical society, Chichester, Eng., C1

journal
2015

Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins.

K Mohanasundaram, N Haworth, M Grover, T Crowley, A Goscinski, M Wouters

(2015), Vol. 6, pp. 1-15, Frontiers in pharmacology, Lausanne, Switzerland, C1

journal

Novel therapeutics for cononary artery disease from genome-wide association study data

M Grover, S Ballouz, K Mohanasundaram, R George, A Goscinski, T Crowely, C Sherman, M Wouters

(2015), Vol. 8, pp. 1-11, BMC medical genomics, London, Eng., C1

journal

Comparative analysis of microRNA expression in mouse and human brown adipose tissue

I Guller, S McNaughton, T Crowley, V Gilsanz, S Kajimura, M Watt, A Russell

(2015), Vol. 16, pp. 1-11, BMC genomics, London, Eng., C1

journal
2014

Identification of novel therapeutics for complex diseases from genome-wide association data

M Grover, S Ballouz, K Mohanasundaram, R George, C H Sherman, T Crowley, M Wouters

(2014), Vol. 7, BMC Medical Genomics, C1

journal

Identification of MicroRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle

E Zacharewicz, P Della Gatta, J Reynolds, A Garnham, T Crowley, A Russell, S Lamon

(2014), Vol. 9, pp. 1-25, PLoS One, San Francisco, Calif., C1

journal
2013

Transcriptome analysis of pigeon milk production - role of cornification and triglyceride synthesis genes

M Gillespie, T Crowley, V Haring, S Wilson, J Harper, J Payne, D Green, P Monaghan, J Donald, K Nicholas, R Moore

(2013), Vol. 14, BMC Genomics, C1

journal

Identification of chicken intestinal microbiota correlated with the efficiency of energy extraction from feed

D Stanley, M Geier, S Denman, V Haring, T Crowley, R Hughes, R Moore

(2013), Vol. 164, pp. 85-92, Veterinary Microbiology, C1

journal

Identification of differential duodenal gene expression levels and microbiota abundance correlated with differences in energy utilisation in chickens

B Konsak, D Stanley, V Haring, M Geier, R Hughes, G Howarth, T Crowley, R Moore

(2013), Vol. 53, pp. 1269-1275, Animal production science, Clayton, Vic., C1-1

journal
2012

The tammar wallaby : a model system to examine domain-specific delivery of milk protein bioactives

K Nicholas, J Sharp, A Watt, S Wanyonyi, T Crowley, M Gillespie, C Lefevre

(2012), Vol. 23, pp. 547-556, Seminars in cell and developmental biology, London, England, C1

journal

Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks

K Schat, J Bingham, J Butler, L Chen, S Lowther, T Crowley, R Moore, R Donis, J Lowenthal

(2012), Vol. 7, pp. 1-11, PLoS One, San Francisco, Calif, C1

journal

Intestinal microbiota associated with differential feed conversion efficiency in chickens

D Stanley, S Denman, R Hughes, M Geier, T Crowley, H Chen, V Haring, R Moore

(2012), Vol. 96, pp. 1361-1369, Applied Microbiology and Biotechnology, C1

journal

Functional similarities between pigeon 'milk' and mammalian milk : induction of immune gene expression and modification of the microbiota

M Gillespie, D Stanley, H Chen, J Donald, K Nicholas, R Moore, T Crowley

(2012), Vol. 7, pp. 1-10, PLoS one, San Francisco, Calif., C1

journal
2011

Histological and global gene expression analysis of the 'lactating' pigeon crop

M Gillespie, V Haring, K McColl, P Monaghan, J Donald, K Nicholas, R Moore, T Crowley

(2011), Vol. 12, pp. 1-9, BMC genomics, London England, C1

journal

Chicken anemia virus: An understanding of the in-vitro host response over time

T Crowley, V Haring, R Moore

(2011), Vol. 24, pp. 3-9, Viral Immunology, C1-1

journal
2003

Isolating conifer DNA: A superior polysaccharide elimination method

T Crowley, M Muralitharan, T Stevenson

(2003), Vol. 21, Plant Molecular Biology Reporter, C1

journal
2002

Marker-assisted selection for cyclaneusma minus in pinus radiata

T Crowley, M Muralitharan, T Stevenson, J Simpson

(2002), pp. 372-375, Plant breeding for the 11th millenium: proceedings of the 12th Australasian Plant Breeding Conference, Perth, Western Australia, E1

conference

Funded Projects at Deakin

Australian Competitive Grants

A novel way to suppress growth of Campylobacter in chickens prior to processing

A/Prof Tamsyn Crowley

RIRDC Grant - Research - Rural Industries Research and Development Corporation

  • 2019: $160,000
  • 2018: $166,952
  • 2017: $54,368
  • 2016: $80,000

Other Public Sector Funding

Mani Grover CSIRO top-up Scholarship - Using the Gentrepid, human candidate gene discovery platform to prioritize candidate genes for human inherited disorders

A/Prof Tamsyn Crowley, Mr Mani Grover

  • 2015: $1,750
  • 2014: $7,000
  • 2013: $7,000

Industry and Other Funding

Saving our antibiotics: an innovative way of restoring bacterial sensitivity to antimicrobials

Dr Ben Wade, A/Prof Tamsyn Crowley, Dr Sarah Shigdar, Dr Anthony Keyburn

  • 2018: $41,000

Other Funding Sources

A new test for the measure of poultry welfare

A/Prof Tamsyn Crowley, Mrs Michelle Cummins

  • 2016: $78,224
  • 2015: $26,074
  • 2014: $5,000
  • 2013: $232,040

miRNAs, a novel target for improving broiler chicken health and production

A/Prof Tamsyn Crowley

  • 2017: $18,635
  • 2016: $18,634
  • 2015: $37,268

Supervisions

Principal Supervisor
2016

Mani Grover

Thesis entitled: Novel therapeutics for complex diseases from genome-wide association data

Doctor of Philosophy (Medicine), School of Medicine

Kaavya Mohanasundaram

Thesis entitled: Mapping the genotype-phenotype relationship in complex disease

Doctor of Philosophy (Medicine), School of Medicine

Associate Supervisor
2019

Smithamol Sithara

Thesis entitled: A beta-cell specific global approach for drug identification in Type 2 Diabetes

Doctor of Philosophy (Medicine), School of Medicine

2018

Shahzad Sadiq

Thesis entitled: Evaluating the Role of Novel microRNAs in Cardiac Hypertrophy

Doctor of Philosophy (Medicine), School of Medicine

2015

Sugeetha Ramakrishnan

Thesis entitled: The relationship between milk, mammary adipocytes and ECM in regulating murine mammary gland involution

Doctor of Philosophy (Medicine), School of Medicine

Vengama Naidu Modepalli

Thesis entitled: The Marsupial: A unique model for understanding the regulation of lung development

Doctor of Philosophy (Medicine), School of Medicine