Profile image of Tania De Koning-Ward

Prof Tania De Koning-Ward

STAFF PROFILE

Position

Professor

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Qualifications

Graduate Certificate of Higher Education, Deakin University, 2011
Doctor of Philosophy, University of Melbourne, 1996
Bachelor of Science, University of Melbourne, 1992

Contact

Biography

Tania de Koning-Ward is a Professor in Molecular Microbiology and an NHMRC Senior Research Fellow within the School of Medicine and the Institute for Mental Health and Clinical Translation. She is currently the leader of the Infection, Immunity and Cancer Theme at IMPACT and she also heads a vibrant research team of postdocs, research assistants, PhD and Honours students in understanding the molecular basis of malaria.

Prof de Koning-Ward obtained her PhD from the University of Melbourne in 1996 and after two postdoctoral stints at Leiden University in The Netherlands, and at The Walter and Eliza Hall Institute in Melbourne as a Howard Florey Repatriation Fellow, she established her own research group within the School of Medicine in 2008 just as the School was opening its doors to its first intake of medical students.

Read more on Tania's profile

Career highlights

• NHMRC Howard Florey Centenary Fellowship (2000-2001)
• Deakin University Award for Research Excellence (2010)
• NHMRC Research Excellence Award (2010)
• NHMRC Career Development Fellowship (2011)
• Commonwealth Health Minister’s Prize for Excellence in Health and Medical       Research (2011)
• Smart Geelong Network Biotechnology Award (2012)
• Smart Geelong Network Researcher of the Year Award (Highly Commended) (2012)
• Deakin University Health Faculty Award for Innovation in Teaching (2012)
• NHMRC Senior Research Fellowship (2018-2022)

Research interests

Malaria is one of the world’s most devastating human health problems, give rise to ~229 million cases each year, ~409,000 of which will be fatal. Unfortunately, there is no highly efficacious licenced malaria vaccine and resistance to currently available anti-malaria drugs is widespread. Thus, there is a desperate need to identify new intervention strategies to reduce the global malaria parasite burden.

Prof de Koning-Ward’s research program aims to investigate a molecular level, key parasite-host interactions that enable malaria parasites to thrive and survive in their host and cause disease. She utilises both human and rodent malaria transgenesis systems to genetically modify malaria genes to dissect gene function. The use of both transgenesis systems enables the characterisation of proteins in the clinically relevant human malaria parasite, which is predominantly cultured in blood cells in vitro, and the dissection of the functional significance and contribution of these proteins to pathogenesis and immunity using an in vivo model of malaria infection. By understanding the key mechanisms by which parasites are able to survive within their host and cause disease, her research aims to discover new drug targets that can be used to prevent the large morbidity and mortality associated with malaria infections.

We are now recruiting Honours and PhD Students to work on the following project areas. Please email expressions of interest to Prof de Koning-Ward.

Teaching interests

Professor de Koning-Ward joined the School of Medicine at Deakin University when it was opening its doors to its first intake of medical students. For several years she coordinated the Infection, Defence and Repair Unit for 1st year medical students. She developed the School of Medicine’s Honours Course and more recently the Masters of Philosophy Program for which she is currently the Course Director.

Knowledge areas

Infectious diseases, microbiology, parasitology, immunology, molecular biology, cellular biology, biochemistry, functional genomics, genetic engineering, pathogenesis, virulence, animal models of disease, host-pathogen interaction

Projects

Malaria is one of the world’s most devastating human health problems, give rise to ~229 million cases each year, ~409,000 of which will be fatal. Unfortunately, there is no highly efficacious licenced malaria vaccine and resistance to currently available anti-malaria drugs is widespread. Thus, there is a desperate need to identify new intervention strategies to reduce the global malaria parasite burden.

Prof de Koning-Ward’s research program aims to investigate a molecular level, key parasite-host interactions that enable malaria parasites to thrive and survive in their host and cause disease. She utilises both human and rodent malaria transgenesis systems to genetically modify malaria genes to dissect gene function. The use of both transgenesis systems enables the characterisation of proteins in the clinically relevant human malaria parasite, which is predominantly cultured in blood cells in vitro, and the dissection of the functional significance and contribution of these proteins to pathogenesis and immunity using an in vivo model of malaria infection. By understanding the key mechanisms by which parasites are able to survive within their host and cause disease, her research aims to discover new drug targets that can be used to prevent the large morbidity and mortality associated with malaria infections.

We are now recruiting Honours and PhD Students to work on the following project areas. Please email expressions of interest to Prof de Koning-Ward. 


• Understanding how malaria parasites remodel the host cells in which they reside
• Dissecting how malaria parasites obtain nutrients essential to their survival
• Dissecting host proteins that contribute to malaria pathogenesis
• Characterising the role of malaria aminopeptidases in hemoglobin digestion
• Dissecting how malaria parasites traffic diverse proteins to distinct cellular locations
• Screening for drugs that target malaria parasites and delineating their mode of action

Publications

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2021

Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion

W Nguyen, M Dans, A Ngo, M Gancheva, O Romeo, S Duffy, T de Koning-Ward, K Lowes, H Sabroux, V Avery, D Wilson, P Gilson, B Sleebs

(2021), Vol. 214, pp. 1-27, European journal of medicinal chemistry, Amsterdam, The Netherlands, C1

journal article

Characterisation of complexes formed by parasite proteins exported into the host cell compartment of Plasmodium falciparum infected red blood cells

T Jonsdottir, N Counihan, J Modak, B Kouskousis, P Sanders, M Gabriela, H Bullen, B Crabb, T de Koning-Ward, P Gilson

(2021), pp. 1-14, Cellular microbiology, Chichester, Eng., C1

journal article

How malaria parasites acquire nutrients from their host

N Counihan, J Modak, T de Koning-Ward

(2021), Vol. 9, pp. 1-10, Frontiers in cell and developmental biology, Lausanne, Switzerland, C1

journal article

Perivascular macrophages create an intravascular niche for CD8ĭ⁺ T cell localisation prior to the onset of fatal experimental cerebral malaria

J Qin, M Lovelace, A Mitchell, T de Koning-Ward, G Grau, S Pai

(2021), Vol. 10, pp. 1-18, Clinical and translational immunology, Chichester, Eng., C1

journal article

Defining the Essential Exportome of the Malaria Parasite

T Jonsdottir, M Gabriela, B Crabb, T F. de Koning-Ward, P Gilson

(2021), Vol. 37, pp. 664-675, Trends in Parasitology, Amsterdam, The Netherlands, C1

journal article
2020

Host Porphobilinogen Deaminase Deficiency Confers Malaria Resistance in Plasmodium chabaudi but Not in Plasmodium berghei or Plasmodium falciparum During Intraerythrocytic Growth

Cilly Schnider, Hao Yang, Lora Starrs, Anna Ehmann, Farid Rahimi, Elena Di Pierro, Giovanna Graziadei, Kathryn Matthews, Tania De Koning-Ward, Denis Bauer, Simon Foote, Brendan McMorran, Gaetan Burgio

(2020), Vol. 10, pp. 1-12, Frontiers in Cellular and Infection Microbiology, Lausanne, Switzerland, C1

journal article

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

M Dans, G Weiss, D Wilson, B Sleebs, B Crabb, T de Koning-Ward, P Gilson

(2020), Vol. 50, pp. 235-252, International Journal for Parasitology, Amsterdam, The Netherlands, C1

journal article

Acute Plasmodium berghei Mouse Infection Elicits Perturbed Erythropoiesis With Features That Overlap With Anemia of Chronic Disease

A Lakkavaram, R Lundie, H Do, A Ward, T de Koning-Ward

(2020), Vol. 11, pp. 1-19, Frontiers in Microbiology, Lausanne, Switzerland, C1

journal article

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

A Valencia-Hernandez, W Ng, N Ghazanfari, S Ghilas, M de Menezes, L Holz, C Huang, K English, M Naung, P Tan, K Tullett, T Steiner, M Enders, L Beattie, Y Chua, C Jones, A Cozijnsen, V Mollard, Y Cai, D Bowen, A Purcell, N La Gruta, J Villadangos, T de Koning-Ward, A Barry, W Barchet, I Cockburn, G McFadden, S Gras, M Lahoud, P Bertolino, R Schittenhelm, I Caminschi, W Heath, D Fernandez-Ruiz

(2020), Vol. 27, pp. 950-962, Cell Host and Microbe, Amsterdam, The Netherlands, C1

journal article

Plasmodium translocon component EXP2 facilitates hepatocyte invasion

J Mello-Vieira, F Enguita, T de Koning-Ward, V Zuzarte-Luís, M Mota

(2020), Vol. 11, pp. 1-13, Nature Communications, Berlin, Germany, C1

journal article
2019

Illuminating how malaria parasites export proteins into host erythrocytes

Kathryn Matthews, Ethan Pitman, Tania de Koning-Ward

(2019), Vol. 21, pp. 1-10, Cellular microbiology, Chichester, Eng., C1

journal article

Targeting malaria parasite invasion of red blood cells as an antimalarial strategy

Amy Burns, Madeline Dans, Juan Balbin, Tania De Koning-Ward, Paul Gilson, James Beeson, Michelle Boyle, Danny Wilson

(2019), Vol. 43, pp. 223-238, FEMS microbiology reviews, Oxford, Eng., C1

journal article

Uncoupling the threading and unfoldase actions of Plasmodium HSP101 reveals differences in export between soluble and insoluble proteins

K Matthews, M Kalanon, T de Koning-Ward

(2019), Vol. 10, pp. 1-18, mBio, Washington, D.C., C1

journal article

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

P Gilson, R Kumarasingha, J Thompson, X Zhang, J Penington, R Kalhor, H Bullen, A Lehane, M Dans, T de Koning-Ward, J Holien, T Soares da Costa, M Hulett, M Buskes, B Crabb, K Kirk, A Papenfuss, A Cowman, B Abbott

(2019), Vol. 9, Scientific reports, London, Eng., C1

journal article
2018

The cysteine protease dipeptidyl aminopeptidase 3 does not contribute to egress of Plasmodium falciparum from host red blood cells

Sreejoyee Ghosh, Scott Chisholm, Madeline Dans, Asha Lakkavaram, Kit Kennedy, Stuart Ralph, Natalie Counihan, Tania de Koning-Ward

(2018), Vol. 13, pp. 1-16, PLoS one, San Francisco, Calif., C1

journal article

The malaria parasite Plasmodium falciparum Sortilin is essential for merozoite formation and apical complex biogenesis

Stéphanie Hallée, Natalie Counihan, Kathryn Matthews, Tania de Koning-Ward, Dave Richard

(2018), Vol. 20, pp. 1-16, Cellular Microbiology, London, Eng., C1

journal article

The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface

Scott Chisholm, Ming Kalanon, Thomas Nebl, Paul Sanders, Kathryn Matthews, Benjamin Dickerman, Paul Gilson, Tania de Koning-Ward

(2018), Vol. 285, pp. 2037-2055, FEBS journal, Chichester, Eng., C1

journal article
2017

Host cell remodelling in malaria parasites: a new pool of potential drug targets

P Gilson, S Chisholm, B Crabb, T de Koning-Ward

(2017), Vol. 47, pp. 119-127, International journal of parasitology, Amsterdam, The Netherlands, C1

journal article

The Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth

S Ghosh, K Kennedy, P Sanders, K Matthews, S Ralph, N Counihan, T de Koning-Ward

(2017), Vol. 19, pp. 1-16, Cellular microbiology, Chichester, Eng., C1

journal article

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

N Counihan, S Chisholm, H Bullen, A Srivastava, P Sanders, T Jonsdottir, G Weiss, S Ghosh, B Crabb, D Creek, P Gilson, T de Koning-Ward

(2017), Vol. 6, pp. 1-31, eLife, Cambridge, Eng., C1

journal article

An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

S Batinovic, E McHugh, S Chisholm, K Matthews, B Liu, L Dumont, S Charnaud, M Schneider, P Gilson, T de Koning-Ward, M Dixon, L Tilley

(2017), Vol. 8, pp. 1-14, Nature communications, London, Eng., C1

journal article

Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malaria

D Fernandez-Ruiz, L Lau, N Ghazanfari, C Jones, W Ng, G Davey, D Berthold, L Holz, Y Kato, M Enders, G Bayarsaikhan, S Hendriks, L Lansink, J Engel, M Soon, K James, A Cozijnsen, V Mollard, A Uboldi, C Tonkin, T de Koning-Ward, P Gilson, T Kaisho, A Haque, B Crabb, F Carbone, G McFadden, W Heath

(2017), Vol. 199, pp. 4165-4179, Journal of immunology, Bethesda, Md., C1

journal article
2016

The PTEX component EXP2 is critical for establishing a patent malaria infection in mice

M Kalanon, D Bargieri, A Sturm, K Matthews, S Ghosh, C Goodman, S Thiberge, V Mollard, G McFadden, R Menard, T de Koning-Ward

(2016), Vol. 18, pp. 399-412, Cellular microbiology, Weinheim, Germany, C1

journal article

Contrasting inducible knockdown of the auxiliary PTEX component PTEX88 in P. falciparum and P. berghei unmasks a role in parasite virulence

S Chisholm, E McHugh, R Lundie, M Dixon, S Ghosh, M O'Keefe, L Tilley, M Kalanon, T de Koning-Ward

(2016), Vol. 11, pp. 1-21, PLoS one, San Fransisco, Calif., C1-1

journal article

Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150

B Elsworth, P Sanders, T Nebl, S Batinovic, M Kalanon, C Nie, S Charnaud, H Bullen, T de Koning-Ward, L Tilley, B Crabb, P Gilson

(2016), Vol. 18, pp. 1551-1569, Cell Microbiology, Chichester, Eng., C1

journal article

Plasmodium species: master renovators of their host cells

T de Koning-Ward, M Dixon, L Tilley, P Gilson

(2016), Vol. 14, pp. 494-507, Nature reviews microbiology, London, Eng., C1

journal article

Plasmodium falciparum nucleosomes exhibit reduced stability and lost sequence dependent nucleosome positioning

E Silberhorn, U Schwartz, P Löffler, S Schmitz, A Symelka, T de Koning-Ward, R Merkl, G Längst

(2016), Vol. 12, pp. 1-29, PLoS pathogens, San Francisco, Calif., C1

journal article
2015

Advances in molecular genetic systems in malaria

T de Koning-Ward, P Gilson, B Crabb

(2015), Vol. 13, pp. 373-387, Nature reviews microbiology, London, Eng., C1

journal article
2014

PTEX is an essential nexus for protein export in malaria parasites

B Elsworth, K Matthews, C Nie, M Kalanon, S Charnaud, P Sanders, S Chisholm, N Counihan, P Shaw, P Pino, J Chan, M Azevedo, S Rogerson, J Beeson, B Crabb, P Gilson, T de Koning-Ward

(2014), Vol. 511, pp. 587-591, Nature, London, United Kingdom, C1

journal article

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

L Lau, D Fernandez-Ruiz, V Mollard, A Sturm, M Neller, A Cozijnsen, J Gregory, G Davey, C Jones, Y Lin, A Haque, C Engwerda, C Nie, D Hansen, K Murphy, A Papenfuss, J Miles, S Burrows, T de Koning-Ward, G McFadden, F Carbone, B Crabb, W Heath

(2014), Vol. 10, pp. 1-16, PLoS pathogens, San Francisco, CA, C1

journal article
2013

Host Cell Remodelling and Protein Trafficking

Silvia Haase, Hayley Bullen, Sarah Charnaud, Brendan Crabb, Paul Gilson, Tania de Koning-Ward

(2013), pp. 199-219, MALARIA PARASITES: COMPARATIVE GENOMICS , EVOLUTION AND MOLECULAR BIOLOGY, B1

book chapter

The Exported Protein PbCP1 Localises to Cleft-Like Structures in the Rodent Malaria Parasite Plasmodium berghei

S Haase, E Hanssen, K Matthews, M Kalanon, T de Koning-Ward

(2013), Vol. 8, PLoS ONE, C1

journal article

Plasmodium rhoptry proteins: Why order is important

N Counihan, M Kalanon, R Coppel, T De Koning-Ward

(2013), Vol. 29, pp. 228-236, Trends in Parasitology, C1

journal article

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

K Matthews, M Kalanon, S Chisholm, A Sturm, C Goodman, M Dixon, P Sanders, T Nebl, F Fraser, S Haase, G Mcfadden, P Gilson, B Crabb, T De Koning-Ward

(2013), Vol. 89, pp. 1167-1186, Molecular Microbiology, C1

journal article
2012

Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

H Bullen, S Charnaud, M Kalanon, D Riglar, C Dekiwadia, N Kangwanrangsan, M Torii, T Tsuboi, J Baum, S Ralph, A Cowman, T De Koning-Ward, B Crabb, P Gilsona

(2012), Vol. 287, pp. 7871-7884, Journal of Biological Chemistry, C1

journal article

Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)

F Ehlgen, J Pham, T de Koning-Ward, A Cowman, S Ralph

(2012), Vol. 7, PLoS ONE, C1

journal article
2011

Blood-stage plasmodium berghei infection generates a potent, specific CD8+ T-cell response despite residence largely in cells lacking MHC i processing machinery

L Lau, D Fernandez Ruiz, G Davey, T De Koning-Ward, A Papenfuss, F Carbone, A Brooks, B Crabb, W Heath

(2011), Vol. 204, pp. 1989-1996, Journal of Infectious Diseases, C1

journal article

Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

B Crabb, T de Koning-Ward, P Gilson

(2011), Vol. 9, BMC Biology, C1

journal article

A research agenda for malaria eradication: basic science and enabling technologies

R Dinglasan, M Mota, J Baum, O Billker, T Bousema, V McGovern, I Mueller, R Amino, Q Bassat, M Bogyo, G Christophides, K Deitsch, A Djimde, M Duraisingh, F Dzinjalamala, C Happi, V Heussler, J Kramarik, T de Koning-Ward, M Lacerda, M Laufer, P Lim, M Llinas, J Martinez-Barnetche, F Okumu, J Rasgon, A Serazin, P Sharma, R Sinden, D Wirth

(2011), Vol. 8, pp. 1-6, PLoS Medicine, San Francisco, Calif., C1-1

journal article
2010

New insights into protein export in malaria parasites

S Haase, T de Koning-Ward

(2010), Vol. 12, pp. 580-587, Cellular Microbiology, C1

journal article

Protein export in Plasmodium parasites: From the endoplasmic reticulum to the vacuolar export machine

B Crabb, T de Koning-Ward, P Gilson

(2010), Vol. 40, pp. 509-513, International Journal for Parasitology, C1

journal article

Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria

F Amante, A Haque, A Stanley, F Rivera, L Randall, Y Wilson, G Yeo, C Pieper, B Crabb, T De Koning-Ward, R Lundie, M Good, A Pinzon-Charry, M Pearson, M Duke, D McManus, A Loukas, G Hill, C Engwerda

(2010), Vol. 185, pp. 3632-3642, Journal of Immunology, C1

journal article

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum

M El Bakkouri, A Pow, A Mulichak, K Cheung, J Artz, M Amani, S Fell, T de Koning-Ward, C Goodman, G McFadden, J Ortega, R Hui, W Houry

(2010), Vol. 404, pp. 456-477, Journal of Molecular Biology, C1

journal article

An aspartyl protease directs malaria effector proteins to the host cell

J Boddey, A Hodder, S Günther, P Gilson, H Patsiouras, E Kapp, J Pearce, T De Koning-Ward, R Simpson, B Crabb, A Cowman

(2010), Vol. 463, pp. 627-631, Nature, C1

journal article
2009

Keeping it simple: an easy method for manipulating the expression levels of malaria proteins

T de Koning-Ward, P Gilson

(2009), Vol. 25, pp. 4-7, Trends in Parasitology, C1-1

journal article

Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

J Baum, A Papenfuss, G Mair, C Janse, D Vlachou, A Waters, A Cowman, B Crabb, T De Koning-Ward

(2009), Vol. 37, pp. 3788-3798, Nucleic Acids Research, C1-1

journal article

A newly discovered protein export machine in malaria parasites

T De Koning-Ward, P Gilson, J Boddey, M Rug, B Smith, A Papenfuss, P Sanders, R Lundie, A Maier, A Cowman, B Crabb

(2009), Vol. 459, pp. 945-949, Nature, C1-1

journal article
2008

Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8α+ dendritic cells

R Lundie, T De Koning-Ward, G Davey, C Nie, D Hansen, S Lei, J Mintern, G Belz, L Schofield, F Carbone, J Villadangos, B Crabb, W Heath

(2008), Vol. 105, pp. 14509-14514, Proceedings of the National Academy of Sciences of the United States of America, C1

journal article

Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development

T de Koning-Ward, D Drew, J Chesson, J Beeson, B Crabb

(2008), Vol. 159, pp. 69-72, Molecular and Biochemical Parasitology, C1

journal article

Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections

E Murhandarwati, C Black, L Wang, S Weisman, T De Koning-Ward, J Baird, E Tjitra, T Richie, B Crabb, R Coppel

(2008), Vol. 198, pp. 1212-1218, Journal of Infectious Diseases, C1-1

journal article

The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum

T De Koning-Ward, A Olivieri, L Bertuccini, A Hood, F Silvestrini, K Charvalias, P Berzosa Díaz, G Camarda, T McElwain, T Papenfuss, J Healer, L Baldassarri, B Crabb, P Alano, L Ranford-Cartwright

(2008), Vol. 67, pp. 278-290, Molecular Microbiology, C1-1

journal article

MSP119 miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking

P Gilson, R O'Donnell, T Nebl, P Sanders, M Wickham, T McElwain, T De Koning-Ward, B Crabb

(2008), Vol. 68, pp. 124-138, Molecular Microbiology, C1-1

journal article
2007

The importance of human FcγRI in mediating protection to malaria

R McIntosh, J Shi, R Jennings, J Chappel, T De Koning-Ward, T Smith, J Green, M Van Egmond, J Leusen, M Lazarou, J Van De Winkel, T Jones, B Crabb, A Holder, R Pleass

(2007), Vol. 3, pp. 0647-0658, PLoS Pathogens, C1-1

journal article

Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: Implications for vaccine and drug design

J McCoubrie, S Miller, T Sargeant, R Good, A Hodder, T Speed, T De Koning-Ward, B Crabb

(2007), Vol. 75, pp. 5565-5574, Infection and Immunity, C1-1

journal article
2006

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

N Wilson, G Behrens, R Lundie, C Smith, J Waithman, L Young, S Forehan, A Mount, R Steptoe, K Shortman, T de Koning-Ward, G Belz, F Carbone, B Crabb, W Heath, J Villadangos

(2006), Vol. 7, pp. 165-172, Nature Immunology, C1-1

journal article
2005

Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators

M Meissner, E Krejany, P Gilson, T De Koning-Ward, D Soldati, B Crabb

(2005), Vol. 102, pp. 2980-2985, Proceedings of the National Academy of Sciences of the United States of America, C1-1

journal article
2004

Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-119) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa

C John, R O'Donnell, P Sumba, A Moormann, T De Koning-Ward, C King, J Kazura, B Crabb

(2004), Vol. 173, pp. 666-672, Journal of Immunology, C1-1

journal article
2003

A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies

T De Koning-Ward, R O'Donnell, D Drew, R Thomson, T Speed, B Crabb

(2003), Vol. 198, pp. 869-875, Journal of Experimental Medicine, C1-1

journal article

CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses

D Hansen, M Siomos, T de Koning-Ward, L Buckingham, B Crabb, L Schofield

(2003), Vol. 33, pp. 2588-2598, European Journal of Immunology, C1-1

journal article
2002

A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle

S Miller, R Good, D Drew, M Delorenzi, P Sanders, A Hodder, T Speed, A Cowman, T de Koning-Ward, B Crabb

(2002), Vol. 277, pp. 47524-47532, Journal of biological chemistry, Rockville, Md., C1-1

journal article
2001

Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria

R O'Donnell, T de Koning-Ward, R Burt, M Bockarie, J Reeder, A Cowman, B Crabb

(2001), Vol. 193, pp. 1403-1412, Journal of experimental medicine, New York, N.Y., C1-1

journal article

P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions

A Tomas, G Margos, G Dimopoulos, L van Lin, T de Koning-Ward, R Sinha, P Lupetti, A Beetsma, M Rodriguez, M Karras, A Hager, J Mendoza, G Butcher, F Kafatos, C Janse, A Waters, R Sinden

(2001), Vol. 20, pp. 3975-3983, EMBO journal, Chichester, Eng., C1-1

journal article

Puromycin-N-acetyltransferase as a selectable marker for use in plasmodium falciparum

T de Koning-Ward, A Waters, B Crabb

(2001), Vol. 117, pp. 155-160, Molecular & biochemical parasitology, Amsterdam, The Netherlands, C1-1

journal article

Complementation of Plasmodium berghei TRAP knockout parasites using human dihydrofolate reductase gene as a selectable marker

A Sultan, V Thathy, T de Koning-Ward, V Nussenzweig

(2001), Vol. 113, pp. 151-156, Molecular & biochemical parasitology, Amsterdam, The Netherlands, C1-1

journal article
2000

The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome

T de Koning-Ward, D Fidock, V Thathy, R Menard, R van Spaendonk, A Waters, C Janse

(2000), Vol. 106, pp. 199-212, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1

journal article

The development of genetic tools for dissecting the biology of malaria parasites

T de Koning-Ward, C Janse, A Waters

(2000), Vol. 54, pp. 157-185, Annual review of microbiology, Palo Alto, Calif., C1-1

journal article
1999

Analysis of stage specificity of promoters in Plasmodium berghei using luciferase as a reporter

T de Koning-Ward, M Sperança, A Waters, C Janse

(1999), Vol. 100, pp. 141-146, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1

journal article
1998

Effect of bacterial invasion of macrophages on the outcome of assays to assess bacterium-macrophage interactions

T de Koning-Ward, T Grant, F Oppedisano, R Robins-Browne

(1998), Vol. 215, pp. 39-44, Journal of immunological methods, Amsterdam, The Netherlands, C1-1

journal article

Hemolytic-uremic syndrome following urinary tract infection with enterohemorrhagic Escherichia coli: case report and review

M Starr, V Bennett-Wood, A Bigham, T de Koning-Ward, A Bordun, D Lightfoot, K Bettelheim, C Jones, R Robins-Browne

(1998), Vol. 27, pp. 310-315, Clinical infectious diseases, Oxford, Eng., C1-1

journal article

Stable expression of green fluorescent protein in blood and mosquito stages of Plasmodium berghei

T de Koning-Ward, A Thomas, A Waters, C Janse

(1998), Vol. 97, pp. 247-252, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1

journal article
1996

Analysis of the urease gene complex of members of the genus Yersinia

T de Koning-Ward, R Robins-Browne

(1996), Vol. 182, pp. 225-228, Gene, Amsterdam, The Netherlands, C1-1

journal article
1995

Contribution of urease to acid tolerance in Yersinia enterocolitica

T De Koning-Ward, R Robins-Browne

(1995), Vol. 63, pp. 3790-3795, Infection and immunity, Washington, D.C., C1-1

journal article
1994

Characterisation of the urease-encoding gene complex of Yersinia enterocolitica

T de Koning-Ward, A Ward, R Robins-Browne

(1994), Vol. 145, pp. 25-32, Gene, Amsterdam, The Netherlands, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Dissecting the contribution of malaria translocon components to pathogenesis

Prof Tania De Koning-Ward

NHMRC Project Grant

  • 2011: $100,444
  • 2010: $98,689
  • 2009: $127,450

Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts

Dr Paul Gilson, Prof Tania De Koning-Ward, Dr Justin Boddey

NHMRC Project Grant

  • 2010: $45,000

Dissection of protein export in Plasmodium

Prof Tania De Koning-Ward

NHMRC CDF - Career Development Fellowship

  • 2014: $113,863
  • 2013: $111,960
  • 2012: $109,980
  • 2011: $158,142

Functional dissection of the malaria protein export machinery

Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2015: $1,624
  • 2014: $142,475
  • 2013: $99,365
  • 2012: $25,601

Functional dissection of the malaria RhopH complex and its contribution to new permeation pathways

Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2018: $35,534
  • 2017: $135,283
  • 2016: $92,219
  • 2015: $98,341

The structural resolution of PTEX, the translocon of virulence proteins and malaria parasites

Prof Brendan Crabb, A/Prof Travis Beddoe, Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2016: $54,346
  • 2015: $43,477
  • 2014: $32,608

Investigating why malaria parasites have a unique translocon

Prof Tania De Koning-Ward, Dr Paul Gilson

ARC - Discovery Projects

  • 2018: $127,980
  • 2017: $121,255
  • 2016: $90,241

Breaking malaria's lethal grip: Targeting the assembly of an adhesive complex on infected red blood cells

Prof Leann Tilley, Dr Paul Gilson, Prof Tania De Koning-Ward, Dr Matthew Dixon

NHMRC Project Grant

  • 2017: $43,276
  • 2016: $43,276
  • 2015: $47,507

Interaction of malaria parasites with their host

Prof Tania De Koning-Ward

NHMRC - Research Fellowship

  • 2021: $124,206
  • 2020: $133,627
  • 2019: $131,782
  • 2018: $129,834

The role of novel and essential bromodomain proteins in coordinating malaria parasite gene regulation and their potential as anti-malarial targets

Dr Michael Duffy, Prof Tania De Koning-Ward, Prof Stefan Knapp

NHMRC Project Grant

  • 2019: $48,000
  • 2018: $50,000
  • 2017: $50,000

Functional resolution of PTEX, the exporter of virulence factors in malaria parasites.

Prof Brendan Crabb, A/Prof Travis Beddoe, Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2020: $39,700
  • 2019: $39,700
  • 2018: $39,700
  • 2017: $39,700

Role of plasmepsin V and PTEX complex in Plasmodium liver infection

Dr Justin Boddey, Prof Tania De Koning-Ward, Dr Kelly Rogers, Prof Norman Kneteman

NHMRC Project Grant

  • 2020: $59,836
  • 2019: $47,869
  • 2018: $35,901

Deciphering the molecular constituents, assembly and structure of the Plasmodium new permeability pathways

Prof Tania De Koning-Ward, Dr Rowena Martin, Dr Joyanta Modak

NHMRC - Ideas Grant

  • 2021: $221,509
  • 2020: $133,452

Multidisciplinary catalyst to discover and progress novel antimalarial drugs

Prof Susan Charman, Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Synergy Grants

  • 2021: $124,999
  • 2020: $166,666

Other Public Sector Funding

The role of host factors in viral pathogenesis

Prof Tania De Koning-Ward, Ms Katherine Birrer

  • 2012: $4,257
  • 2011: $3,092

Identification of novel protective malaria vaccine antigen candidate

Prof Tania De Koning-Ward, Ms Sreejoyee Ghosh

  • 2012: $90,000

Other Funding Sources

Collaborative High Bio-Containment immunological Research Facility

Prof Alister Ward, Dr Linfa Wang, Prof John Stambas, Dr John Lowenthal, Prof Ralph Tripp, Prof Bill Buttemer, Prof Johnson Mak, Prof Tania De Koning-Ward

  • 2012: $105,000
  • 2011: $100,000

The role of host factors in viral pathogenesis

Prof Tania De Koning-Ward, Ms Katherine Birrer

  • 2011: $7,000

Supervisions

Principal Supervisor
2021

Mikha Gabriela

Thesis entitled: Molecular mechanism of cargo recognition by the Plasmodium translocon of exported proteins

Doctor of Philosophy (Medicine), School of Medicine

2019

Rebecca Edgar

Thesis entitled: Starving the Malaria Parasite

Master of Philosophy (Medicine), School of Medicine

2017

Asha Latha Lakkavaram

Thesis entitled: Dissecting the mechanism of severe malaria

Doctor of Philosophy (Medicine), School of Medicine

2016

Sreejoyee Ghosh

Thesis entitled: Dissecting the function of essential rhoptry genes of the malaria parasite

Doctor of Philosophy (Medicine), School of Medicine

Scott Chisholm

Thesis entitled: Characterisation of PTEX88, a component of the Plasmodium translocon

Doctor of Philosophy (Medicine), School of Medicine

2015

Kathryn Mifsud

Thesis entitled: PTEX characterisation and its role in Plasmodium virulence and survival

Doctor of Philosophy (Medicine), School of Medicine

2013

Ming Tsung Lee

Thesis entitled: Cost and Utilisation of Physical Therapies in Taiwan

Doctor of Philosophy (Medicine), School of Medicine

2012

Katherine Birrer

Thesis entitled: Silencing Host Genes Using RNAi to Impact Virus Growth in vitro Methods for reducing cotton wax.

MAppSc (Medicine) (High cost), School of Medicine

Associate Supervisor
2021

Shasha Zhao

Thesis entitled: The Role of miRNAs in Influenza Virus Pathogenesis and Immunity

Doctor of Philosophy (Medicine), School of Medicine

2018

Saeed Mahmoudimeimand

Thesis entitled: Control of cytokine receptor signalling by CISH

Doctor of Philosophy (Medicine), School of Medicine

2016

Hanumantsingh Tanwar

Thesis entitled: Regulation of HIV Gag conformation and complex formation

Doctor of Philosophy (Medicine), School of Medicine

2013

Kate Goossens

Thesis entitled: Comparative analysis of type III interferon receptor and interferon-stimulated genes

Doctor of Philosophy (Medicine), School of Medicine