Profile image of Tania De Koning-Ward

Prof Tania De Koning-Ward





Faculty of Health


School of Medicine


Geelong Waurn Ponds Campus


Graduate Certificate of Higher Education, Deakin University, 2011
Doctor of Philosophy, University of Melbourne, 1996
Bachelor of Science, University of Melbourne, 1992


Career highlights

Profile of Associate Professor de Koning-Ward

The consistent theme of A/Prof de Koning-Ward’s research has been to investigate virulence mechanisms of, and immunity to human and animal model pathogens, using molecular genetics as a primary tool. A/Prof de Koning-Ward has developed experience in both rodent and human malaria transgenesis systems during postdoctoral stints at Leiden University (The Netherlands) and The Walter and Eliza Hall Institute, the latter commencing with an NHMRC Howard Florey Centenary Fellowship.  Following these postdoctoral positions, A/Prof de Koning-Ward was appointed as Senior Lecturer within Deakin University’s Medical School, a combined research and teaching position, with the latter involving the coordination of the Infection, Defence and Repair Unit for 1st year medical students. Since 2011 she has relinquished this teaching component to take up an NHMRC fellowship to expand her independent research program at Deakin University. She was awarded the Commonwealth Health Minister’s Prize for Excellence in Health and Medical Research in 2011.



Malaria is one of the world’s most devastating human health problems, with Plasmodium falciparum, the most lethal of the human malaria species, causing ~660 000 deaths annually.  Unfortunately there is no licenced malaria vaccine and resistance to currently available anti-malaria drugs is now very widespread. Thus, there is a desperate need to identify new intervention strategies to reduce the global malaria parasite burden.

The focus of our research is investigations into the virulence mechanisms of, and development of immunity to, malaria parasites using a range of molecular, biochemical and microscopy approaches. We utilise both human (P. falciparum) and rodent (P. berghei) malaria transgenesis systems to genetically modify malaria genes to dissect gene function or to introduce reporter genes to study the localisation of parasite proteins within the infected red blood cell (RBC). The use of both transgenesis systems enables the characterisation of proteins in the clinically relevant human malaria parasite, which is predominantly cultured in blood cells in vitro, and the dissection of the functional significance and contribution of these proteins to pathogenesis and immunity using an in vivo mouse model of malaria infection. By understanding the key mechanisms by which parasites are able to survive within their host and cause disease, we aim to discover new drug targets that can be used to prevent the large morbidity and mortality associated with malaria infections.


We are now recruiting Honours and PhD Students to work on the following project areas. Please email expressions of interest to A/Prof de Koning-Ward.

1. Understanding how malaria parasites remodel their host red blood cell (RBC).
Malaria parasites spend nearly their entire cell cycle within RBCs and to thrive inside the bloodstream the parasites export ~ 8% of their encoded genome (~350 proteins) into the host RBC. Here, the exported proteins are involved in the acquisition of nutrients from host serum or have virulence-associated roles. In 2009, we made a significant breakthrough in our understanding of protein export through the identification of a novel protein machinery that exports parasite proteins into the host RBC (de Koning-Ward et al, Nature, 2009).  Since this machinery provides a common portal through which all or most of the exported proteins must pass and these proteins are involved in processes crucial to parasite virulence and viability, this translocon represents an outstanding target for malaria chemotherapeutic intervention. Our work is now aimed at characterising the various components of this machinery so that the mechanistic details of how proteins are trafficked from the parasite and into to RBC can be unravelled.

2. Characterisation of exported proteins
In addition to understanding the trafficking pathways that are used by the malaria parasite to export its proteins into its host cells, we are also characterising different classes of exported proteins to delineate their role in host cell remodelling and pathogenesis.

3. Dissecting the contribution of key malaria proteins to pathogenesis and immune evasion
We use reverse genetics to modify malaria parasites in combination with infection studies, post-genomic, biochemical, and cell biology approaches to identify and validate new drug and vaccine targets. 

4. Dissecting the role of rhoptry body proteins in parasite invasion and establishment of new permeation pathways in the infected RBC.

5. Dissecting the molecular mechanisms by which malaria parasites are able to cause severe anemia in susceptible individuals.


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Illuminating how malaria parasites export proteins into host erythrocytes

Kathryn Matthews, Ethan Pitman, Tania de Koning-Ward

(2019), Vol. 21, pp. 1-10, Cellular microbiology, Chichester, Eng., C1


Targeting malaria parasite invasion of red blood cells as an antimalarial strategy

Amy Burns, Madeline Dans, Juan Balbin, Tania De Koning-Ward, Paul Gilson, James Beeson, Michelle Boyle, Danny Wilson

(2019), Vol. 43, pp. 223-238, FEMS microbiology reviews, Oxford, Eng., C1


Uncoupling the threading and unfoldase actions of Plasmodium HSP101 reveals differences in export between soluble and insoluble proteins

K Matthews, M Kalanon, T de Koning-Ward

(2019), Vol. 10, pp. 1-18, mBio, Washington, D.C., C1


A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

P Gilson, R Kumarasingha, J Thompson, X Zhang, J Penington, R Kalhor, H Bullen, A Lehane, M Dans, T de Koning-Ward, J Holien, T Soares da Costa, M Hulett, M Buskes, B Crabb, K Kirk, A Papenfuss, A Cowman, B Abbott

(2019), Vol. 9, Scientific reports, London, Eng., C1


The cysteine protease dipeptidyl aminopeptidase 3 does not contribute to egress of Plasmodium falciparum from host red blood cells

Sreejoyee Ghosh, Scott Chisholm, Madeline Dans, Asha Lakkavaram, Kit Kennedy, Stuart Ralph, Natalie Counihan, Tania de Koning-Ward

(2018), Vol. 13, pp. 1-16, PLoS one, San Francisco, Calif., C1


The malaria parasite Plasmodium falciparum Sortilin is essential for merozoite formation and apical complex biogenesis

Stphanie Halle, Natalie Counihan, Kathryn Matthews, Tania de Koning-Ward, Dave Richard

(2018), Vol. 20, pp. 1-16, Cellular Microbiology, London, Eng., C1


The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface

Scott Chisholm, Ming Kalanon, Thomas Nebl, Paul Sanders, Kathryn Matthews, Benjamin Dickerman, Paul Gilson, Tania de Koning-Ward

(2018), Vol. 285, pp. 2037-2055, FEBS journal, Chichester, Eng., C1


Host cell remodelling in malaria parasites: a new pool of potential drug targets

P Gilson, S Chisholm, B Crabb, T de Koning-Ward

(2017), Vol. 47, pp. 119-127, International journal of parasitology, Amsterdam, The Netherlands, C1


The Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth

S Ghosh, K Kennedy, P Sanders, K Matthews, S Ralph, N Counihan, T de Koning-Ward

(2017), Vol. 19, pp. 1-16, Cellular microbiology, Chichester, Eng., C1


Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

N Counihan, S Chisholm, H Bullen, A Srivastava, P Sanders, T Jonsdottir, G Weiss, S Ghosh, B Crabb, D Creek, P Gilson, T de Koning-Ward

(2017), Vol. 6, pp. 1-31, eLife, Cambridge, Eng., C1


An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

S Batinovic, E McHugh, S Chisholm, K Matthews, B Liu, L Dumont, S Charnaud, M Schneider, P Gilson, T de Koning-Ward, M Dixon, L Tilley

(2017), Vol. 8, pp. 1-14, Nature communications, London, Eng., C1


Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malaria

D Fernandez-Ruiz, L Lau, N Ghazanfari, C Jones, W Ng, G Davey, D Berthold, L Holz, Y Kato, M Enders, G Bayarsaikhan, S Hendriks, L Lansink, J Engel, M Soon, K James, A Cozijnsen, V Mollard, A Uboldi, C Tonkin, T de Koning-Ward, P Gilson, T Kaisho, A Haque, B Crabb, F Carbone, G McFadden, W Heath

(2017), Vol. 199, pp. 4165-4179, Journal of immunology, Bethesda, Md., C1


The PTEX component EXP2 is critical for establishing a patent malaria infection in mice

M Kalanon, D Bargieri, A Sturm, K Matthews, S Ghosh, C Goodman, S Thiberge, V Mollard, G McFadden, R Menard, T de Koning-Ward

(2016), Vol. 18, pp. 399-412, Cellular microbiology, Weinheim, Germany, C1


Contrasting inducible knockdown of the auxiliary PTEX component PTEX88 in P. falciparum and P. berghei unmasks a role in parasite virulence

S Chisholm, E McHugh, R Lundie, M Dixon, S Ghosh, M O'Keefe, L Tilley, M Kalanon, T de Koning-Ward

(2016), Vol. 11, pp. 1-21, PLoS one, San Fransisco, Calif., C1-1


Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150

B Elsworth, P Sanders, T Nebl, S Batinovic, M Kalanon, C Nie, S Charnaud, H Bullen, T de Koning-Ward, L Tilley, B Crabb, P Gilson

(2016), Vol. 18, pp. 1551-1569, Cell Microbiology, Chichester, Eng., C1


Plasmodium species: master renovators of their host cells

T de Koning-Ward, M Dixon, L Tilley, P Gilson

(2016), Vol. 14, pp. 494-507, Nature reviews microbiology, London, Eng., C1


Plasmodium falciparum nucleosomes exhibit reduced stability and lost sequence dependent nucleosome positioning

E Silberhorn, U Schwartz, P Lffler, S Schmitz, A Symelka, T de Koning-Ward, R Merkl, G Lngst

(2016), Vol. 12, pp. 1-29, PLoS pathogens, San Francisco, Calif., C1


Advances in molecular genetic systems in malaria

T de Koning-Ward, P Gilson, B Crabb

(2015), Vol. 13, pp. 373-387, Nature reviews microbiology, London, Eng., C1


PTEX is an essential nexus for protein export in malaria parasites

B Elsworth, K Matthews, C Nie, M Kalanon, S Charnaud, P Sanders, S Chisholm, N Counihan, P Shaw, P Pino, J Chan, M Azevedo, S Rogerson, J Beeson, B Crabb, P Gilson, T de Koning-Ward

(2014), Vol. 511, pp. 587-591, Nature, London, United Kingdom, C1


CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria

L Lau, D Fernandez-Ruiz, V Mollard, A Sturm, M Neller, A Cozijnsen, J Gregory, G Davey, C Jones, Y Lin, A Haque, C Engwerda, C Nie, D Hansen, K Murphy, A Papenfuss, J Miles, S Burrows, T de Koning-Ward, G McFadden, F Carbone, B Crabb, W Heath

(2014), Vol. 10, pp. 1-16, PLoS pathogens, San Francisco, CA, C1


Host Cell Remodelling and Protein Trafficking

Silvia Haase, Hayley Bullen, Sarah Charnaud, Brendan Crabb, Paul Gilson, Tania de Koning-Ward



The Exported Protein PbCP1 Localises to Cleft-Like Structures in the Rodent Malaria Parasite Plasmodium berghei

S Haase, E Hanssen, K Matthews, M Kalanon, T de Koning-Ward

(2013), Vol. 8, PLoS ONE, C1


Plasmodium rhoptry proteins: Why order is important

N Counihan, M Kalanon, R Coppel, T De Koning-Ward

(2013), Vol. 29, pp. 228-236, Trends in Parasitology, C1


The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

K Matthews, M Kalanon, S Chisholm, A Sturm, C Goodman, M Dixon, P Sanders, T Nebl, F Fraser, S Haase, G Mcfadden, P Gilson, B Crabb, T De Koning-Ward

(2013), Vol. 89, pp. 1167-1186, Molecular Microbiology, C1


Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

H Bullen, S Charnaud, M Kalanon, D Riglar, C Dekiwadia, N Kangwanrangsan, M Torii, T Tsuboi, J Baum, S Ralph, A Cowman, T De Koning-Ward, B Crabb, P Gilsona

(2012), Vol. 287, pp. 7871-7884, Journal of Biological Chemistry, C1


Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)

F Ehlgen, J Pham, T de Koning-Ward, A Cowman, S Ralph

(2012), Vol. 7, PLoS ONE, C1


Blood-stage plasmodium berghei infection generates a potent, specific CD8+ T-cell response despite residence largely in cells lacking MHC i processing machinery

L Lau, D Fernandez Ruiz, G Davey, T De Koning-Ward, A Papenfuss, F Carbone, A Brooks, B Crabb, W Heath

(2011), Vol. 204, pp. 1989-1996, Journal of Infectious Diseases, C1


Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

B Crabb, T de Koning-Ward, P Gilson

(2011), Vol. 9, BMC Biology, C1


A research agenda for malaria eradication: basic science and enabling technologies

R Dinglasan, M Mota, J Baum, O Billker, T Bousema, V McGovern, I Mueller, R Amino, Q Bassat, M Bogyo, G Christophides, K Deitsch, A Djimde, M Duraisingh, F Dzinjalamala, C Happi, V Heussler, J Kramarik, T de Koning-Ward, M Lacerda, M Laufer, P Lim, M Llinas, J Martinez-Barnetche, F Okumu, J Rasgon, A Serazin, P Sharma, R Sinden, D Wirth

(2011), Vol. 8, pp. 1-6, PLoS Medicine, San Francisco, Calif., C1-1


New insights into protein export in malaria parasites

S Haase, T de Koning-Ward

(2010), Vol. 12, pp. 580-587, Cellular Microbiology, C1


Protein export in Plasmodium parasites: From the endoplasmic reticulum to the vacuolar export machine

B Crabb, T de Koning-Ward, P Gilson

(2010), Vol. 40, pp. 509-513, International Journal for Parasitology, C1


Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria

F Amante, A Haque, A Stanley, F Rivera, L Randall, Y Wilson, G Yeo, C Pieper, B Crabb, T De Koning-Ward, R Lundie, M Good, A Pinzon-Charry, M Pearson, M Duke, D McManus, A Loukas, G Hill, C Engwerda

(2010), Vol. 185, pp. 3632-3642, Journal of Immunology, C1


The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum

M El Bakkouri, A Pow, A Mulichak, K Cheung, J Artz, M Amani, S Fell, T de Koning-Ward, C Goodman, G McFadden, J Ortega, R Hui, W Houry

(2010), Vol. 404, pp. 456-477, Journal of Molecular Biology, C1


An aspartyl protease directs malaria effector proteins to the host cell

J Boddey, A Hodder, S Gnther, P Gilson, H Patsiouras, E Kapp, J Pearce, T De Koning-Ward, R Simpson, B Crabb, A Cowman

(2010), Vol. 463, pp. 627-631, Nature, C1


Keeping it simple: an easy method for manipulating the expression levels of malaria proteins

T de Koning-Ward, P Gilson

(2009), Vol. 25, pp. 4-7, Trends in Parasitology, C1-1


Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

J Baum, A Papenfuss, G Mair, C Janse, D Vlachou, A Waters, A Cowman, B Crabb, T De Koning-Ward

(2009), Vol. 37, pp. 3788-3798, Nucleic Acids Research, C1-1


A newly discovered protein export machine in malaria parasites

T De Koning-Ward, P Gilson, J Boddey, M Rug, B Smith, A Papenfuss, P Sanders, R Lundie, A Maier, A Cowman, B Crabb

(2009), Vol. 459, pp. 945-949, Nature, C1-1


Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8?+ dendritic cells

R Lundie, T De Koning-Ward, G Davey, C Nie, D Hansen, S Lei, J Mintern, G Belz, L Schofield, F Carbone, J Villadangos, B Crabb, W Heath

(2008), Vol. 105, pp. 14509-14514, Proceedings of the National Academy of Sciences of the United States of America, C1


Truncation of Plasmodium berghei merozoite surface protein 8 does not affect in vivo blood-stage development

T de Koning-Ward, D Drew, J Chesson, J Beeson, B Crabb

(2008), Vol. 159, pp. 69-72, Molecular and Biochemical Parasitology, C1


Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections

E Murhandarwati, C Black, L Wang, S Weisman, T De Koning-Ward, J Baird, E Tjitra, T Richie, B Crabb, R Coppel

(2008), Vol. 198, pp. 1212-1218, Journal of Infectious Diseases, C1-1


The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum

T De Koning-Ward, A Olivieri, L Bertuccini, A Hood, F Silvestrini, K Charvalias, P Berzosa Daz, G Camarda, T McElwain, T Papenfuss, J Healer, L Baldassarri, B Crabb, P Alano, L Ranford-Cartwright

(2008), Vol. 67, pp. 278-290, Molecular Microbiology, C1-1


MSP119 miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking

P Gilson, R O'Donnell, T Nebl, P Sanders, M Wickham, T McElwain, T De Koning-Ward, B Crabb

(2008), Vol. 68, pp. 124-138, Molecular Microbiology, C1-1


The importance of human Fc?RI in mediating protection to malaria

R McIntosh, J Shi, R Jennings, J Chappel, T De Koning-Ward, T Smith, J Green, M Van Egmond, J Leusen, M Lazarou, J Van De Winkel, T Jones, B Crabb, A Holder, R Pleass

(2007), Vol. 3, pp. 0647-0658, PLoS Pathogens, C1-1


Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: Implications for vaccine and drug design

J McCoubrie, S Miller, T Sargeant, R Good, A Hodder, T Speed, T De Koning-Ward, B Crabb

(2007), Vol. 75, pp. 5565-5574, Infection and Immunity, C1-1


Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

N Wilson, G Behrens, R Lundie, C Smith, J Waithman, L Young, S Forehan, A Mount, R Steptoe, K Shortman, T de Koning-Ward, G Belz, F Carbone, B Crabb, W Heath, J Villadangos

(2006), Vol. 7, pp. 165-172, Nature Immunology, C1-1


Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators

M Meissner, E Krejany, P Gilson, T De Koning-Ward, D Soldati, B Crabb

(2005), Vol. 102, pp. 2980-2985, Proceedings of the National Academy of Sciences of the United States of America, C1-1


Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-119) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa

C John, R O'Donnell, P Sumba, A Moormann, T De Koning-Ward, C King, J Kazura, B Crabb

(2004), Vol. 173, pp. 666-672, Journal of Immunology, C1-1


A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies

T De Koning-Ward, R O'Donnell, D Drew, R Thomson, T Speed, B Crabb

(2003), Vol. 198, pp. 869-875, Journal of Experimental Medicine, C1-1


CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses

D Hansen, M Siomos, T de Koning-Ward, L Buckingham, B Crabb, L Schofield

(2003), Vol. 33, pp. 2588-2598, European journal of immunology, Weinheim, Germany, C1-1


A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle

S Miller, R Good, D Drew, M Delorenzi, P Sanders, A Hodder, T Speed, A Cowman, T de Koning-Ward, B Crabb

(2002), Vol. 277, pp. 47524-47532, Journal of biological chemistry, Rockville, Md., C1-1


Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria

R O'Donnell, T de Koning-Ward, R Burt, M Bockarie, J Reeder, A Cowman, B Crabb

(2001), Vol. 193, pp. 1403-1412, Journal of experimental medicine, New York, N.Y., C1-1


P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions

A Tomas, G Margos, G Dimopoulos, L van Lin, T de Koning-Ward, R Sinha, P Lupetti, A Beetsma, M Rodriguez, M Karras, A Hager, J Mendoza, G Butcher, F Kafatos, C Janse, A Waters, R Sinden

(2001), Vol. 20, pp. 3975-3983, EMBO journal, Chichester, Eng., C1-1


Puromycin-N-acetyltransferase as a selectable marker for use in plasmodium falciparum

T de Koning-Ward, A Waters, B Crabb

(2001), Vol. 117, pp. 155-160, Molecular & biochemical parasitology, Amsterdam, The Netherlands, C1-1


Complementation of Plasmodium berghei TRAP knockout parasites using human dihydrofolate reductase gene as a selectable marker

A Sultan, V Thathy, T de Koning-Ward, V Nussenzweig

(2001), Vol. 113, pp. 151-156, Molecular & biochemical parasitology, Amsterdam, The Netherlands, C1-1


The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome

T de Koning-Ward, D Fidock, V Thathy, R Menard, R van Spaendonk, A Waters, C Janse

(2000), Vol. 106, pp. 199-212, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1


The development of genetic tools for dissecting the biology of malaria parasites

T de Koning-Ward, C Janse, A Waters

(2000), Vol. 54, pp. 157-185, Annual review of microbiology, Palo Alto, Calif., C1-1


Analysis of stage specificity of promoters in Plasmodium berghei using luciferase as a reporter

T de Koning-Ward, M Sperana, A Waters, C Janse

(1999), Vol. 100, pp. 141-146, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1


Effect of bacterial invasion of macrophages on the outcome of assays to assess bacterium-macrophage interactions

T de Koning-Ward, T Grant, F Oppedisano, R Robins-Browne

(1998), Vol. 215, pp. 39-44, Journal of immunological methods, Amsterdam, The Netherlands, C1-1


Hemolytic-uremic syndrome following urinary tract infection with enterohemorrhagic Escherichia coli: case report and review

M Starr, V Bennett-Wood, A Bigham, T de Koning-Ward, A Bordun, D Lightfoot, K Bettelheim, C Jones, R Robins-Browne

(1998), Vol. 27, pp. 310-315, Clinical infectious diseases, Oxford, Eng., C1-1


Stable expression of green fluorescent protein in blood and mosquito stages of Plasmodium berghei

T de Koning-Ward, A Thomas, A Waters, C Janse

(1998), Vol. 97, pp. 247-252, Molecular and biochemical parasitology, Amsterdam, The Netherlands, C1-1


Analysis of the urease gene complex of members of the genus Yersinia

T de Koning-Ward, R Robins-Browne

(1996), Vol. 182, pp. 225-228, Gene, Amsterdam, The Netherlands, C1-1


Contribution of urease to acid tolerance in Yersinia enterocolitica

T De Koning-Ward, R Robins-Browne

(1995), Vol. 63, pp. 3790-3795, Infection and immunity, Washington, D.C., C1-1


Characterisation of the urease-encoding gene complex of Yersinia enterocolitica

T de Koning-Ward, A Ward, R Robins-Browne

(1994), Vol. 145, pp. 25-32, Gene, Amsterdam, The Netherlands, C1-1


Funded Projects at Deakin

Australian Competitive Grants

Dissecting the contribution of malaria translocon components to pathogenesis

Prof Tania De Koning-Ward

NHMRC Project Grant

  • 2011: $100,444
  • 2010: $98,689
  • 2009: $127,450

Identification of the Plasmodium falciparum translocon that exports parasite proteins into their erythocytic hosts

Dr Paul Gilson, Prof Tania De Koning-Ward, Dr Justin Boddey

NHMRC Project Grant

  • 2010: $45,000

Dissection of protein export in Plasmodium

Prof Tania De Koning-Ward

NHMRC CDF - Career Development Fellowship

  • 2014: $113,863
  • 2013: $111,960
  • 2012: $109,980
  • 2011: $158,142

Functional dissection of the malaria protein export machinery

Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2015: $1,624
  • 2014: $142,475
  • 2013: $99,365
  • 2012: $25,601

Functional dissection of the malaria RhopH complex and its contribution to new permeation pathways

Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2018: $35,534
  • 2017: $135,283
  • 2016: $92,219
  • 2015: $98,341

The structural resolution of PTEX, the translocon of virulence proteins and malaria parasites

Prof Brendan Crabb, A/Prof Travis Beddoe, Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2016: $54,346
  • 2015: $43,477
  • 2014: $32,608

Investigating why malaria parasites have a unique translocon

Prof Tania De Koning-Ward, Dr Paul Gilson

ARC - Discovery Projects

  • 2018: $127,980
  • 2017: $121,255
  • 2016: $90,241

Breaking malaria's lethal grip: Targeting the assembly of an adhesive complex on infected red blood cells

Prof Leann Tilley, Dr Paul Gilson, Prof Tania De Koning-Ward, Dr Matthew Dixon

NHMRC Project Grant

  • 2017: $43,276
  • 2016: $43,276
  • 2015: $47,507

Interaction of malaria parasites with their host

Prof Tania De Koning-Ward

NHMRC - Research Fellowship

  • 2020: $22,271
  • 2019: $131,782
  • 2018: $129,834

The role of novel and essential bromodomain proteins in coordinating malaria parasite gene regulation and their potential as anti-malarial targets

Dr Michael Duffy, Prof Tania De Koning-Ward, Prof Stefan Knapp

NHMRC Project Grant

  • 2019: $48,000
  • 2018: $50,000
  • 2017: $50,000

Functional resolution of PTEX, the exporter of virulence factors in malaria parasites.

Prof Brendan Crabb, A/Prof Travis Beddoe, Prof Tania De Koning-Ward, Dr Paul Gilson

NHMRC Project Grant

  • 2019: $39,700
  • 2018: $39,700
  • 2017: $39,700

Role of plasmepsin V and PTEX complex in Plasmodium liver infection

Dr Justin Boddey, Prof Tania De Koning-Ward, Dr Kelly Rogers, Prof Norman Kneteman

NHMRC Project Grant

  • 2020: $11,967
  • 2019: $47,869
  • 2018: $35,901

Other Public Sector Funding

The role of host factors in viral pathogenesis

Prof Tania De Koning-Ward, Ms Katherine Birrer

  • 2012: $4,257
  • 2011: $3,092

Identification of novel protective malaria vaccine antigen candidate

Prof Tania De Koning-Ward, Ms Sreejoyee Ghosh

  • 2012: $90,000

Other Funding Sources

Collaborative High Bio-Containment immunological Research Facility

Prof Alister Ward, Dr Linfa Wang, Prof John Stambas, Dr John Lowenthal, Prof Ralph Tripp, Prof Johnson Mak, Prof Bill Buttemer, Prof Tania De Koning-Ward

  • 2012: $105,000
  • 2011: $100,000

The role of host factors in viral pathogenesis

Prof Tania De Koning-Ward, Ms Katherine Birrer

  • 2011: $7,000


Principal Supervisor

Rebecca Edgar

Thesis entitled: Starving the Malaria Parasite

Master of Philosophy (Medicine), School of Medicine


Asha Latha Lakkavaram

Thesis entitled: Dissecting the mechanism of severe malaria

Doctor of Philosophy (Medicine), School of Medicine


Sreejoyee Ghosh

Thesis entitled: Dissecting the function of essential rhoptry genes of the malaria parasite

Doctor of Philosophy (Medicine), School of Medicine

Scott Chisholm

Thesis entitled: Characterisation of PTEX88, a component of the Plasmodium translocon

Doctor of Philosophy (Medicine), School of Medicine


Kathryn Mifsud

Thesis entitled: PTEX characterisation and its role in Plasmodium virulence and survival

Doctor of Philosophy (Medicine), School of Medicine


Ming Tsung Lee

Thesis entitled: Cost and Utilisation of Physical Therapies in Taiwan

Doctor of Philosophy (Medicine), School of Medicine


Katherine Birrer

Thesis entitled: Silencing Host Genes Using RNAi to Impact Virus Growth in vitro Methods for reducing cotton wax.

MAppSc (Medicine) (High cost), School of Medicine

Associate Supervisor

Saeed Mahmoudimeimand

Thesis entitled: Control of cytokine receptor signalling by CISH

Doctor of Philosophy (Medicine), School of Medicine


Hanumantsingh Tanwar

Thesis entitled: Regulation of HIV Gag conformation and complex formation

Doctor of Philosophy (Medicine), School of Medicine


Kate Goossens

Thesis entitled: Comparative analysis of type III interferon receptor and interferon-stimulated genes

Doctor of Philosophy (Medicine), School of Medicine