Profile image of Tim Silk

Dr Tim Silk

STAFF PROFILE

Position

Associate Professor of Psychology

Faculty

Faculty of Health

Department

School of Psychology

Campus

Melbourne Burwood Campus

Qualifications

Doctor of Philosophy, Monash University, 2007
Bachelor of Behavioural Neuroscience, Monash University, 2004

Contact

tim.silk@deakin.edu.au
+61 3 924 46894

Biography summary

Dr Tim Silk is a cognitive neuroscientist specializing in paediatric neurodevelopmental imaging in order to understand the brain-behaviour interface; when and where that goes awry. Specifically, he is focused on identifying neuroimaging markers that can be used to distinguish children with neurodevelopmental disorders, monitor progression, and predict likely outcome or treatment response.
Dr Silk heads the Brain and Cognitive Development Lab, and currently leads The Neuroimaging of the Children’s Attention Project (NICAP) collecting longitudinal multimodal neuroimaging data in order to understand how brain structure and function change across late childhood to early adolescence for children with and without ADHD, and how those changes reflect ADHD symptom severity and functional outcomes.

Research interests

Developmental Cognitive Neuroscience
Neuroimaging
Neurodevelopmental Disorders
Attention Deficit Hyperactivity Disorder

Affiliations

Developmental Imaging, Murdoch Children’s Research Institute, Australia.


Department of Paediatrics, The University of Melbourne, Australia

Teaching interests

Cognitive Neuroscience (HPS395)
Biological and Neuropsychological Perspectives on Disorder (HPS978)

Research groups

Brain and Cognitive Development Lab, Deakin University
Developmental Neuropsychiatry Team Leader, Developmental Imaging, Murdoch Children’s Research Institute

Awards


2015 Young Scientist Award - World Congress of ADHD, Glasgow, Scotland.

2015 Clinical Sciences Rising Star Award, Murdoch Children's Research Institute.

2013 Selected for Australian Academy of Science’s 2013 Theo Murphy High Flyers Think Tank on Inspiring smarter brain research in Australia

2007 Most Outstanding Doctoral Thesis Award for 2007. 

2007  Selected of the 2007 Brightest Young Minds Summit, Brightest Young Minds Foundation

Projects

Trajectories in brain structure and function for children with ADHD.
An arm of the Children’s Attention Project, this is a large longitudinal neuroimaging project conducted in order to understand how brain structure and function change across late childhood to early adolescence for children with and without ADHD, and how those changes reflect symptoms and functional outcomes.

Understanding the role of epigenetic factors in both typical and atypical brain and cognitive development
The field of developmental epigenomics is beginning to identify how specific environmental factors influence brain structure and function at critical stages of development.  Using both a sample of ADHD and a typically developing twin cohort we are examining whether epigenetic state, or changes in epigenetic state, can predict brain and cognitive development or clinical presentation. In addition, can we identify modifiable environmental factors associated with the changes in epigenetic state.

The influence of puberty on brain and cognitive development.
Adolescence is a dynamic period of brain development that drives cognitive maturity. The hormones involved in puberty directly contribute to shaping brain development.
This project examines how trajectories of brain development and the related maturation of cognitive ability are influenced by the sensitive transition through puberty.

Publications

Filter by

2019

Multimodal structural neuroimaging markers of brain development and ADHD symptoms

Gareth Ball, Charles Malpas, Sila Genc, Daryl Efron, Emma Sciberras, Vicki Anderson, Jan Nicholson, Timothy Silk

(2019), Vol. 176, pp. 57-66, American journal of psychiatry, Washington, DC, C1

journal

Prevalence and predictors of medication use in children with Attention-Deficit/Hyperactivity Disorder: evidence from a community-based longitudinal study

Daryl Efron, Alisha Gulenc, Emma Sciberras, Obioha Ukoumunne, Philip Hazell, Vicki Anderson, Timothy Silk, Jan Nicholson

(2019), Vol. 29, pp. 50-57, Journal of child and adolescent psychopharmacology, New Rochelle, N.Y., C1

journal

White matter organization in developmental coordination disorder: a pilot study exploring the added value of constrained spherical deconvolution

Christian Hyde, Ian Fuelscher, Peter Enticott, Derek Jones, Shawna Farquharson, Tim Silk, Jacqueline Williams, Karen Caeyenberghs

(2019), Vol. 21, pp. 1-13, NeuroImage: clinical, Amsterdam, The Netherlands, C1

journal

A network analysis approach to ADHD symptoms: more than the sum of its parts

Timothy Silk, Charles Malpas, Richard Beare, Daryl Efron, Vicki Anderson, Philip Hazell, Brad Jongeling, Jan Nicholson, Emma Sciberras

(2019), Vol. 14, pp. 1-17, PLoS one, San Francisco, Calif., C1

journal

Characterisation of depressive symptoms in young children with and without attention deficit hyperactivity disorder

Claire Joseph, Subhadra Evans, George Youssef, Tim Silk, Vicki Anderson, Daryl Efron, Emma Sciberras

(2019), pp. 1-10, European child & adolescent psychiatry, Berlin, Germany, C1

journal

Brain imaging of the cortex in ADHD: a coordinated analysis of large-scale clinical and population-based samples

Martine Hoogman, Ryan Muetzel, Joao Guimaraes, Elena Shumskaya, Maarten Mennes, Marcel Zwiers, Neda Jahanshad, Gustavo Sudre, Thomas Wolfers, Eric Earl, Juan Soliva Vila, Yolanda Vives-Gilabert, Sabin Khadka, Stephanie Novotny, Catharina Hartman, Dirk Heslenfeld, Lizanne Schweren, Sara Ambrosino, Bob Oranje, Patrick de Zeeuw, Tiffany Chaim-Avancini, Pedro Rosa, Marcus Zanetti, Charles Malpas, Gregor Kohls, Georg von Polier, Jochen Seitz, Joseph Biederman, Alysa Doyle, Anders Dale, Theo van Erp, Jeffery Epstein, Terry Jernigan, Ramona Baur-Streubel, Georg Ziegler, Kathrin Zierhut, Anouk Schrantee, Marie Hovik, Astri Lundervold, Clare Kelly, Hazel McCarthy, Norbert Skokauskas, Ruth Tuura, Anna Calvo, Sara Lera-Miguel, Rosa Nicolau, Kaylita Chantiluke, Anastasia Christakou, Alasdair Vance, Mara Cercignani, Matt Gabel, Philip Asherson, Sarah Baumeister, Daniel Brandeis, Sarah Hohmann, Ivanei Bramati, Fernanda Tovar-Moll, Andreas Fallgatter, Bernd Kardatzki, Lena Schwarz, Anatoly Anikin, Alexandr Baranov, Tinatin Gogberashvili, Dmitry Kapilushniy, Anastasia Solovieva, Hanan El Marroun, Tonya White, Georgii Karkashadze, Leyla Namazova-Baranova, Thomas Ethofer, Paulo Mattos, Tobias Banaschewski, David Coghill, Kerstin Plessen, Jonna Kuntsi, Mitul Mehta, Yannis Paloyelis, Neil Harrison, Mark Bellgrove, Tim Silk, Ana Cubillo, Katya Rubia, Luisa Lazaro, Silvia Brem, Susanne Walitza, Thomas Frodl, Mariam Zentis, Francisco Castellanos, Yuliya Yoncheva, Jan Haavik, Liesbeth Reneman, Annette Conzelmann, Klaus-Peter Lesch, Paul Pauli, Andreas Reif, Leanne Tamm, Kerstin Konrad, Eileen Weiss, Gerald Busatto, Mario Louza, Sarah Durston, Pieter Hoekstra, Jaap Oosterlaan, Michael Stevens, J Antoni Ramos-Quiroga, Oscar Vilarroya, Damien Fair, Joel Nigg, Paul Thompson, Jan Buitelaar, Stephen Faraone, Philip Shaw, Henning Tiemeier, Janita Bralten, Barbara Franke

(2019), Vol. 176, pp. 531-542, American journal of psychiatry, Arlington, Va., C1

journal

Does the mind wander when the brain takes a break? Local sleep in wakefulness, attentional lapses and mind-wandering

T Andrillon, J Windt, T Silk, S Drummond, M Bellgrove, N Tsuchiya

(2019), Vol. 13, Frontiers in neuroscience, Lausanne, Switzerland, C1

journal
2018

Age, sex, and puberty related development of the corpus callosum: a multi-technique diffusion MRI study

Sila Genc, Charles Malpas, Gareth Ball, Timothy Silk, Marc Seal

(2018), Vol. 223, pp. 2753-2765, Brain structure and function, Berlin, Germany, C1

journal

White matter microstructure predicts longitudinal social cognitive outcomes after paediatric traumatic brain injury: a diffusion tensor imaging study

N Ryan, S Genc, M Beauchamp, K Yeates, S Hearps, C Catroppa, V Anderson, T Silk

(2018), Vol. 48, pp. 679-691, Psychological medicine, Cambridge, Eng., C1-1

journal

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Xiang-Zhen Kong, Samuel Mathias, Tulio Guadalupe, ENIGMA Laterality Working Group, David Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon Fisher, Paul Thompson, Clyde Francks

(2018), Vol. 115, pp. E5154-E5163, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1

journal

Development of white matter fibre density and morphology over childhood: a longitudinal fixel-based analysis

Sila Genc, Robert Smith, Charles Malpas, Vicki Anderson, Jan Nicholson, Daryl Efron, Emma Sciberras, Marc Seal, Timothy Silk

(2018), Vol. 183, pp. 666-676, Neuroimage, Amsterdam, The Netherlands, C1

journal
2017

Research Review: language problems in children with Attention-Deficit Hyperactivity Disorder - a systematic meta-analytic review

H Korrel, K Mueller, T Silk, V Anderson, E Sciberras

(2017), Vol. 58, pp. 640-654, Journal of Child Psychology and Psychiatry, Oxford, Eng., C1

journal

Examining the prospective relationship between family affective responsiveness and theory of mind in chronic paediatric traumatic brain injury

N Ryan, K Mihaljevic, M Beauchamp, C Catroppa, L Crossley, S Hearps, T Silk, C Godfrey, K Yeates, V Anderson

(2017), Vol. 18, pp. 88-101, Brain impairment, Cambridge, Eng., C1-1

journal

Exploring the neuroanatomical correlates of cognitive, affective and conative theory of mind in pediatric acquired brain disorder: a neural systems perspective

N Ryan, C Catroppa, R Beare, T Silk, Stephen Hearps, M Beauchamp, K Yeates, V Anderson

(2017), Vol. 12, pp. 1414-1427, Social cognitive and affective neuroscience, Oxford, Eng, C1

journal

Recovery of white matter following paediatric traumatic brain injury depends on injury severity

S Genc, V Anderson, N Ryan, C Malpas, C Catroppa, M Beauchamp, T Silk

(2017), Vol. 34, pp. 798-806, Journal of neurotrauma, New Rochelle, N.Y., C1

journal

Uncovering the neuroanatomical correlates of cognitive, affective and conative theory of mind in paediatric traumatic brain injury: a neural systems perspective

Nicholas Ryan, Cathy Catroppa, Richard Beare, Timothy Silk, Stephen Hearps, Miriam Beauchamp, Keith Yeates, Vicki Anderson

(2017), Vol. 12, pp. 1414-1427, Social cognitive and affective neurosciences, Oxford, Eng., C1-1

journal

The effect of single-dose methylphenidate on resting-state network functional connectivity in ADHD

Timothy Silk, Charles Malpas, Alasdair Vance, Mark Bellgrove

(2017), Vol. 11, pp. 1422-1431, Brain imaging behavior, New York, N.Y., C1

journal

Atypical neuronal activation during a spatial working memory task in 13-year-old very preterm children

Pia-Maria Arthursson, Deanne Thompson, Megan Spencer-Smith, Jian Chen, Tim Silk, Lex Doyle, Peter Anderson

(2017), Vol. 38, pp. 6172-6184, Human brain mapping, Chichester, Eng., C1

journal

Altered structural connectivity in ADHD: a network based analysis

Richard Beare, Chris Adamson, Mark Bellgrove, Veronika Vilgis, Alasdair Vance, Marc Seal, Timothy Silk

(2017), Vol. 11, pp. 846-858, Brain imaging behavior, New York, N.Y., C1

journal

White matter microstructure in boys with persistent depressive disorder

Veronika Vilgis, Alasdair Vance, Ross Cunnington, Timothy Silk

(2017), Vol. 221, pp. 11-16, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal

White matter alterations at pubertal onset

Sila Genc, Marc Seal, Thijs Dhollander, Charles Malpas, Philip Hazell, Timothy Silk

(2017), Vol. 156, pp. 286-292, NeuroImage, Amsterdam, The Netherlands, C1

journal

Neurite density index is sensitive to age related differences in the developing brain

Sila Genc, Charles Malpas, Scott Holland, Richard Beare, Timothy Silk

(2017), Vol. 148, pp. 373-380, NeuroImage, Amsterdam, The Netherlands, C1

journal
2016

Comorbidity and correlates of disruptive mood dysregulation disorder in 6-8-year-old children with ADHD

M Mulraney, E Schilpzand, P Hazell, J Nicholson, V Anderson, D Efron, T Silk, E Sciberras

(2016), Vol. 25, pp. 321-330, European child and adolescent psychiatry, Berlin, Germany, C1-1

journal

Developmental brain trajectories in children with ADHD and controls: a longitudinal neuroimaging study

T Silk, S Genc, V Anderson, D Efron, P Hazell, J Nicholson, M Kean, C Malpas, E Sciberras

(2016), Vol. 16, pp. 1-9, BMC Psychiatry, London, Eng., C1

journal

Theory of mind mediates the prospective relationship between abnormal social brain network morphology and chronic behavior problems after pediatric traumatic brain injury

Nicholas Ryan, Cathy Catroppa, Richard Beare, Timothy Silk, Louise Crossley, Miriam Beauchamp, Keith Yeates, Vicki Anderson

(2016), Vol. 11, pp. 683-692, Social cognitive and affective neuroscience, Oxford, Eng., C1-1

journal

Uncovering cortico-striatal correlates of cognitive fatigue in pediatric acquired brain disorder: evidence from traumatic brain injury

Nicholas Ryan, Miriam Beauchamp, Richard Beare, Lee Coleman, Michael Ditchfield, Michael Kean, Timothy Silk, Sila Genc, Cathy Catroppa, Vicki Anderson

(2016), Vol. 83, pp. 222-230, Cortex, Amsterdam, The Netherlands, C1-1

journal

Global and local grey matter reductions in boys with ADHD combined type and ADHD inattentive type

Veronika Vilgis, Li Sun, Jian Chen, Timothy Silk, Alasdair Vance

(2016), Vol. 254, pp. 119-126, Psychiatry research: neuroimaging, The Netherlands, C1

journal

Cortical morphometry in attention deficit/hyperactivity disorder: contribution of thickness and surface area to volume

Timothy Silk, Richard Beare, Charles Malpas, Chris Adamson, Veronika Vilgis, Alasdair Vance, Mark Bellgrove

(2016), Vol. 82, pp. 1-10, Cortex, Amsterdam, The Netherlands, C1

journal

Frequency-specific abnormalities in regional homogeneity among children with attention deficit hyperactivity disorder: a resting-state fMRI study

X Yu, B Yuan, Q Cao, L An, P Wang, A Vance, T Silk, Y Zang, Y Wang, L Sun

(2016), Vol. 61, pp. 682-692, Science bulletin, Amsterdam, The Netherlands, C1

journal

Abnormal asymmetry in frontostriatal white matter in children with attention deficit hyperactivity disorder

Timothy Silk, Veronika Vilgis, Chris Adamson, Jian Chen, Lisa Smit, Alasdair Vance, Mark Bellgrove

(2016), Vol. 10, pp. 1080-1089, Brain imaging and behavior, Berlin, Germany, C1

journal
2015

The emergence of age-dependent social cognitive deficits after generalized insult to the developing brain: a longitudinal prospective analysis using susceptibility-weighted imaging

Nicholas Ryan, Cathy Catroppa, Janine Cooper, Richard Beare, Michael Ditchfield, Lee Coleman, Timothy Silk, Louise Crossley, Miriam Beauchamp, Vicki Anderson

(2015), Vol. 36, pp. 1677-1691, Human brain mapping, Chichester, Eng., C1-1

journal

Relationships between acute imaging biomarkers and theory of mind impairment in post-acute pediatric traumatic brain injury: a prospective analysis using susceptibility weighted imaging (SWI)

Nicholas Ryan, Cathy Catroppa, Janine Cooper, Richard Beare, Michael Ditchfield, Lee Coleman, Timothy Silk, Louise Crossley, Kirrily Rogers, Miriam Beauchamp, Keith Yeates, Vicki Anderson

(2015), Vol. 66, pp. 32-38, Neuropsychologia, Amsterdam, The Netherlands, C1-1

journal

Executive function and attention in children and adolescents with depressive disorders: a systematic review

Veronika Vilgis, Timothy Silk, Alasdair Vance

(2015), Vol. 24, pp. 365-384, European child & adolescent psychiatry, Berlin, Germany, C1

journal
2014

Influence of methylphenidate on spatial attention asymmetry in adolescents with attention deficit hyperactivity disorder (ADHD): preliminary findings

Timothy Silk, Daniel Newman, Ranmalee Eramudugolla, Alasdair Vance, Mark Bellgrove

(2014), Vol. 56, pp. 178-183, Neuropsychologia, Amsterdam, The Netherlands, C1

journal

Frontoparietal function in young people with dysthymic disorder (DSM-5: persistent depressive disorder) during spatial working memory

Veronika Vilgis, Jian Chen, Timothy Silk, Ross Cunnington, Alasdair Vance

(2014), Vol. 160, pp. 34-42, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal
2013

Cavum septum pellucidum in pediatric traumatic brain injury

Timothy Silk, Richard Beare, Louise Crossley, Kirrily Rogers, Louise Emsell, Cathy Catroppa, Miriam Beauchamp, Vicki Anderson

(2013), Vol. 213, pp. 186-192, Psychiatry research: neuroimaging, Amsterdam, The Netherlands, C1

journal

Brain extraction using the watershed transform from markers

Richard Beare, Jian Chen, Christopher Adamson, Timothy Silk, Deanne Thompson, Joseph Yang, Vicki Anderson, Marc Seal, Amanda Wood

(2013), Vol. 7, pp. 1-15, Frontiers in neuroinformatics, Lausanne, Switzerland, C1

journal

White matter abnormalities in pediatric obsessive-compulsive disorder

Timothy Silk, Jian Chen, Marc Seal, Alasdair Vance

(2013), Vol. 213, pp. 154-160, Psychiatry research: neuroimaging, Amsterdam, The Netherlands, C1

journal

Widespread decreased grey and white matter in paediatric obsessive-compulsive disorder (OCD): a voxel-based morphometric MRI study

Jian Chen, Tim Silk, Marc Seal, Karen Dally, Alasdair Vance

(2013), Vol. 213, pp. 11-17, Psychiatry research: neuroimaging, Amsterdam, The Netherlands, C1

journal
2010

Spatial working memory and spatial attention rely on common neural processes in the intraparietal sulcus

Timothy Silk, Mark Bellgrove, Pia Wrafter, Jason Mattingley, Ross Cunnington

(2010), Vol. 53, pp. 718-724, Neuroimage, Amsterdam, The Netherlands, C1-1

journal
2009

White-matter abnormalities in attention deficit hyperactivity disorder: A diffusion tensor imaging study

T Silk, A Vance, N Rinehart, J Bradshaw, R Cunnington

(2009), Vol. 30, pp. 2757-2765, Human Brain Mapping, C1-1

journal

Structural development of the basal ganglia in attention deficit hyperactivity disorder: A diffusion tensor imaging study

T Silk, A Vance, N Rinehart, J Bradshaw, R Cunnington

(2009), Vol. 172, pp. 220-225, Psychiatry Research - Neuroimaging, C1-1

journal
2008

Dysfunction in the fronto-parietal network in attention deficit hyperactivity disorder (ADHD): An fMRI study

T Silk, A Vance, N Rinehart, J Bradshaw, R Cunnington

(2008), Vol. 2, pp. 123-131, Brain Imaging and Behavior, C1-1

journal

Human medial frontal cortex activity predicts learning from errors

R Hester, N Barre, K Murphy, T Silk, J Mattingley

(2008), Vol. 18, pp. 1933-1940, Cerebral Cortex, C1-1

journal
2007

Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: A functional MRI study

A Vance, T Silk, M Casey, N Rinehart, J Bradshaw, M Bellgrove, R Cunnington

(2007), Vol. 12, pp. 826-832, Molecular Psychiatry, C1-1

journal

Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention

K Johnson, I Robertson, S Kelly, T Silk, E Barry, A Dibhis, A Watchorn, M Keavey, M Fitzgerald, L Gallagher, M Gill, M Bellgrove

(2007), Vol. 45, pp. 2234-2245, Neuropsychologia, C1-1

journal
2006

Visuospatial processing and the function of prefrontal-parietal networks in autism spectrum disorders: a functional MRI study

T Silk, N Rinehart, J Bradshaw, B Tonge, G Egan, M O'Boyle, R Cunnington

(2006), Vol. 163, pp. 1440-1443, American journal of psychiatry, Arlington, Va., C1-1

journal
2003

Neural correlates of the emergence of consciousness of thirst

G Egan, T Silk, F Zamarripa, J Williams, P Federico, R Cunnington, L Carabott, J Blair-West, R Shade, M McKinley, M Farrell, J Lancaster, G Jacksons, P Fox, D Denton

(2003), Vol. 100, pp. 15241-15246, Proceedings of the National Academy of Sciences of the United States of America, Washington, D.C., C1-1

journal

Funded Projects at Deakin

Industry and Other Funding

Using epigenetics to predict the onset and different development trajectories in ADHD

Dr Tim Silk, A/Prof Jeffrey Craig, A/Prof Emma Sciberras

  • 2018: $105,005

The microstructural basis of DCD and its co-occurrence with ADHD: an advanced constrained deconvolution

Dr Christian Hyde, A/Prof Karen Caeyenberghs, Dr Jacqueline Williams, Dr Ian Fuelscher, Dr Tim Silk, A/Prof Jeffrey Craig, A/Prof Jarrad Lum

  • 2019: $82,134

Supervisions

No completed student supervisions to report