Mr Timothy Connor

Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity

L Hall, J Czeczor, T Connor, J Botella, K De Jong, M Renton, A Genders, K Venardos, S Martin, S Bond, K Aston-Mourney, K Howlett, J Campbell, G Collier, K Walder, M McKenzie, M Ziemann, S McGee

(2024), Vol. 15, pp. 1-13, Nature Communications, London, Eng., C1

Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression

C Bortolasci, S Kidnapillai, B Spolding, T Truong, T Connor, C Swinton, B Panizzutti, Z Liu, A Sanigorski, O Dean, T Crowley, M Richardson, K Bozaoglu, K Vlahos, S Cowdery, B Watmuff, S Steyn, D Wolmarans, B Engelbrecht, C Perry, K Drummond, T Pang, S Jamain, L Gray, S McGee, B Harvey, J Kim, M Leboyer, M Berk, K Walder

(2023), Vol. 25, pp. 661-670, Bipolar Disorders, C1

Characterisation of the hydrogen sulfide system in early diabetic kidney disease

C Bushell, L Forgan, K Aston-Mourney, T Connor, S McGee, B McNeill

(2023), Vol. 71, Journal of molecular endocrinology, C1

Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen

C Bortolasci, E Jaehne, D Hernández, B Spolding, T Connor, B Panizzutti, O Dean, T Crowley, A Yung, L Gray, J Kim, M van den Buuse, M Berk, K Walder

(2023), Vol. 41, pp. 502-513, Neurotoxicity Research, C1

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

S Martin, T Connor, A Sanigorski, K McEwen, D Henstridge, B Nijagal, D De Souza, D Tull, P Meikle, G Kowalski, C Bruce, P Gregorevic, M Febbraio, F Collier, K Walder, S McGee

(2023), Vol. 14, pp. 1-13, Cell Death and Disease, Berlin, Germany, C1

Effects of antipsychotic drugs on energy metabolism

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, S Martin, T Truong, Z Liu, L Gray, G Kowalski, S McGee, J Kim, M Berk, K Walder

(2023), European Archives of Psychiatry and Clinical Neuroscience, Germany, C1

Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism

W Naser, S Maymand, L Rivera, T Connor, C Liongue, C Smith, K Aston-Mourney, D McCulloch, S McGee, A Ward

(2022), Vol. 36, pp. 1-15, FASEB Journal, London, Eng., C1

Transcriptional modulation of the hippo signaling pathway by drugs used to treat bipolar disorder and schizophrenia

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, G Morris, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 22, International Journal of Molecular Sciences, C1

Biological mechanism(S) underpinning the association between antipsychotic drugs and weight gain

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 10, Journal of Clinical Medicine, C1

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

S Kidnapillai, C Bortolasci, M Udawela, B Panizzutti, B Spolding, T Connor, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, E Scarr, M Leboyer, B Dean, M Berk, K Walder

(2020), Vol. 21, pp. 775-783, World Journal of Biological Psychiatry, England, C1

Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurite outgrowth

S Kidnapillai, B Wade, C Bortolasci, B Panizzutti, B Spolding, T Connor, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2020), Vol. 34, pp. 370-379, Journal of Psychopharmacology, United States, C1

Reducing hepatic PKD activity lowers circulating VLDL cholesterol

Amanda Genders, Timothy Connor, Shona Morrison, Simon Bond, Brian Drew, Peter Meikle, Kirsten Howlett, Sean Mcgee

(2020), Vol. 246, pp. 265-276, Journal of Endocrinology, Bristol, Eng., C1

Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity

K De Jong, L Hall, M Renton, T Connor, S Martin, G Kowalski, C Shaw, C Bruce, K Howlett, S McGee

(2020), Vol. 42, Molecular Metabolism, Germany, C1

Transcriptional effects of psychoactive drugs on genes involved in neurogenesis

C Bortolasci, B Spolding, S Kidnapillai, T Connor, T Truong, Z Liu, B Panizzutti, M Richardson, L Gray, M Berk, O Dean, K Walder

(2020), Vol. 21, pp. 1-19, International Journal of Molecular Sciences, C1

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis - a possible therapeutic mechanism

S Kidnapillai, C Bortolasci, B Panizzutti, B Spolding, T Connor, K Bonifacio, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2019), Vol. 20, pp. 766-777, World Journal of Biological Psychiatry, London, Eng., C1

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

J Wali, S Galic, C Tan, E Gurzov, A Frazier, T Connor, J Ge, E Pappas, D Stroud, L Varanasi, C Selck, M Ryan, D Thorburn, B Kemp, B Krishnamurthy, T Kay, S McGee, H Thomas

(2018), Vol. 25, pp. 217-225, Cell Death and Differentiation, England, C1

Mechanisms underpinning the polypharmacy effects of medications in psychiatry

C Bortolasci, B Spolding, E Callaly, S Martin, B Panizzutti, S Kidnapillai, T Connor, K Hasebe, M Mohebbi, O Dean, S McGee, S Dodd, L Gray, M Berk, K Walder

(2018), Vol. 21, pp. 582-591, International Journal of Neuropsychopharmacology, England, C1

APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

J Czeczor, A Genders, K Aston-Mourney, T Connor, L Hall, K Hasebe, M Ellis, K De Jong, D Henstridge, P Meikle, M Febbraio, K Walder, S McGee

(2018), Vol. 237, pp. 311-322, Journal of Endocrinology, England, C1

Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring

A Kaspi, I Khurana, M Ziemann, T Connor, B Spolding, P Zimmet, K Walder, A El-Osta

(2018), Vol. 62, Molecular Nutrition and Food Research, Germany, C1

Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

V Gaur, T Connor, K Venardos, D Henstridge, S Martin, C Swinton, S Morrison, K Aston-Mourney, S Gehrig, R van Ewijk, G Lynch, M Febbraio, G Steinberg, M Hargreaves, K Walder, S McGee

(2017), Vol. 19, pp. 936-943, Diabetes, Obesity and Metabolism, England, C1

Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1

Hypothalamic gene expression is regulated by DNA methylation linking parental diet during pregnancy to offspring's risk of obesity in psammomys obesus

I Khurana, A Kaspi, M Ziemann, T Block, T Connor, B Spolding, A Cooper, P Zimmet, A El-Osta, K Walder

(2017), Vol. 49, pp. S103-S104, Pathology, Amsterdam, The Netherlands, C1

DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus

I Khurana, A Kaspi, M Ziemann, T Block, T Connor, B Spolding, A Cooper, P Zimmet, A El-Osta, K Walder

(2016), Vol. 40, pp. 1079-1088, International Journal of Obesity, England, C1

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

V Gaur, T Connor, A Sanigorski, S Martin, C Bruce, D Henstridge, S Bond, K McEwen, L Kerr-Bayles, T Ashton, C Fleming, M Wu, L Pike Winer, D Chen, G Hudson, J Schwabe, K Baar, M Febbraio, P Gregorevic, F Pfeffer, K Walder, M Hargreaves, S McGee

(2016), Vol. 16, pp. 2802-2810, Cell Reports, United States, C1

Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

T Connor, S Martin, K Howlett, S McGee

(2015), Vol. 42, pp. 109-115, Clinical and Experimental Pharmacology and Physiology, England, London, C1

The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice

K Venardos, K De Jong, M Elkamie, T Connor, S McGee

(2015), Vol. 10, pp. 1-14, PLoS one, San Francisco, Calif., C1-1

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

D Henstridge, C Bruce, B Drew, K Tory, A Kolonics, E Estevez, J Chung, N Watson, T Gardner, R Lee-Young, T Connor, M Watt, K Carpenter, M Hargreaves, S McGee, A Hevener, M Febbraio

(2014), pp. 1-1, Diabetes, Alexandria, Virginia, C1

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli Sand Rat)

B Spolding, T Connor, C Wittmer, L Abreu, A Kaspi, M Ziemann, G Kaur, A Cooper, S Morrison, S Lee, A Sinclair, Y Gibert, J Trevaskis, J Roth, A El-Osta, R Standish, K Walder

(2014), Vol. 9, pp. 1-7, PLoS one, San Francisco, Calif., C1

Non-referenced genome assembly from epigenomic short-read data

A Kaspi, M Ziemann, S Keating, I Khurana, T Connor, B Spolding, A Cooper, R Lazarus, K Walder, P Zimmet, A El-Osta

(2014), Vol. 9, pp. 1329-1338, Epigenetics, United States, C1

Zinc Finger Nuclease mediated knockout of ADP dependent Glucokinase in Cancer cell lines: Effects on cell survival and Mitochondrial Oxidative Metabolism

S Richter, S Morrison, T Connor, J Su, C Print, R Roniums, S McGee, W Wilson

(2013), Vol. 8, pp. 1-17, PLOS One, San Francisco, CA, C1

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

C Winbanks, J Chen, H Qian, Y Liu, B Bernardo, C Beyer, K Watt, R Thomson, T Connor, B Turner, J McMullen, L Larsson, S McGee, C Harrison, P Gregorevic

(2013), Vol. 203, pp. 345-357, The Journal of Cell Biology, New York, NY, C1

Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

W Sanchez, S McGee, T Connor, B Mottram, A Wilkinson, J Whitehead, S Vuckovic, L Catley

(2013), Vol. 108, pp. 1624-1633, British journal of cancer, London, England, C1

Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients

V Haynes, T Connor, A Tchernof, H Vidal, S Dubois

(2013), Vol. 108, pp. 90-94, Molecular genetics and metabolism, Waltham, Mass., C1-1

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo

N Konstantopoulos, J Molero, S McGee, B Spolding, T Connor, M de Vries, S Wanyonyi, R Fahey, S Morrison, C Swinton, S Jones, A Cooper, L Garcia-Guerra, V Foletta, G Krippner, S Andrikopoulos, K Walder

(2012), Vol. 61, pp. 2146-2154, Diabetes, Alexandria, Va., C1

Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat

R Teperino, S Amann, M Bayer, S McGee, A Loipetzberger, T Connor, C Jaeger, B Kammerer, L Winter, G Wiche, K Dalgaard, M Selvaraj, M Gaster, R Lee-Young, M Febbraio, C Knauf, P Cani, F Aberger, J Penniger, J Pospisilik, H Esterbauer

(2012), Vol. 151, pp. 414-426, Cell, Cambridge, Mass., C1

Metallothionein 2a Gene Expression is Increased in Subcutaneous Adipose Tissue of Type 2 Diabetic Patients

Vanessa Haynes, Timothy Connor, Andre Tchernof, Hubert Vidal, Severine Dubois

(2012), Vol. 3, JOURNAL OF DIABETES & METABOLISM, C1

A gene expression signature for insulin resistance

N Konstantopoulos, V Foletta, D Segal, K Shields, A Sanigorski, K Windmill, C Swinton, T Connor, S Wanyonyi, T Dyer, R Fahey, R Watt, J Curran, J Molero, G Krippner, G Collier, D James, J Blangero, J Jowett, K Walder

(2011), Vol. 43, pp. 110-120, Physiological genomics, Bethesda, Md., C1

Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity

H Su, J Gunter, M de Vries, T Connor, S Wanyonyi, F Newell, D Segal, J Molero, O Reizes, J Prins, L Hutley, K Walder, J Whitehead

(2009), Vol. 386, pp. 351-355, Biochemical and biophysical research communications, San Diego, Calif., C1