At present, around 50 million people worldwide suffer from Dementia. The World Alzheimer Report 2016 states that most people with dementia do not have access to appropriate healthcare facilities. Thus, the need of the hour lies in developing a rapid, discriminatory screening tool that is more accessible to general population and supports early detection of cognitive decline.
Proteomics studies are extremely important in understanding the altered metabolic pathways and intracellular modulations. In addition, proteomics studies are often complemented with metabolomics analysis and thus can directly correlate to the phenotype of an individual. Since earlier reports have shown cholesterol levels to modulate the amyloid aggregation in Alzheimer’s disease, lipidomics studies have become quite pertinent in such cases. In this era of personalized medicine, these multi-omics approaches play a key role in studying disease diagnosis and prognosis, and can be extensively employed in early disease detection to identify the appropriate biomarkers and perturbed metabolic pathways.
This study aims to define a panel of biomarkers in blood that can distinguish individuals with cognitive decline from normal individuals. This project proposes to contribute towards the identification of key regulatory biomolecules that can translate into a potent blood-based biomarker panel for an early detection of cognitive decline. Several high-throughput mass spectrometry approaches like proteomics, metabolomics, lipidomics etc. and immunoassays will be employed in this study to unravel the key biomolecules whose expression patterns change during the aging process ensuring high levels of sensitivity and specificity. The detection of a panel of biomarkers in blood has immense medical implications and can be further extrapolated to clinical settings.
Applications close 5pm, Thursday 31st October 2019.
This scholarship is available over 3 years.
- Stipend of $27,596 per annum tax exempt (2019 rate)
To be eligible you must:
- be a domestic candidate (domestic includes candidates with Australian Citizenship, Australian Permanent Residency or New Zealand Citizenship).
- meet Deakin's PhD entry requirements
- be enrolling full time and hold an honours degree (first class) or an equivalent standard master's degree with a substantial research component.
Please refer to the research degree entry pathways page for further information.
How to apply
Learn more about submitting a successful application on the How to apply page
For more information about this scholarship, please contact A/Prof Veer Gupta
A/Prof Veer Gupta
Associate Professor in Neurobiology
Email Veer Gupta
+61 3 5227 3008