Malaria, caused by infection with Plasmodium parasites, is a disease of global significance, with 216 million cases reported in 2015, of which ~440,000 infections were fatal. Plasmodium parasites depend on coordinated regulation of gene expression to be able to develop and propagate within their host as well as cause disease. The nucleosome landscape, histone modifications and nuclear architecture all contribute to the regulation of Plasmodium genes. Since the mediators that control these factors represent promising anti-malaria drugs targets, their identification and elucidation of their mechanism of action is highly warranted.
This project is part of Deakin University and University of Georgia (UGA) collaborative agreement. The student will be required to spend some time studying abroad at UGA.
The aims of this project are to determine the essentiality and role of proteins involved in malaria gene regulation, particularly bromodomain proteins that bind histone acetylations, and chromatin remodeller enzymes. This will involve epitope tagging the genes encoding these proteins to assess localisation and interacting partners as well as conditional knockdown of their expression to determine the impact on parasite growth and genes involved in host cell invasion, host cell remodelling, gametocytogenesis and other pathways that are critical to the malaria parasite.
Applications close 5pm, Thursday 31 October 2019.
This scholarship is available over 3 years.
- Stipend of $27,596 per annum tax exempt (2019 rate)
- Relocation allowance of $500-1500 (for single to family) for students moving from interstate or overseas
To be eligible you must:
- be either a domestic (domestic includes candidates with Australian Citizenship, Australian Permanent Residency or New Zealand Citizenship).
- meet Deakin's PhD entry requirements
- be enrolling full time and hold an honours degree (first class) or an equivalent standard master's degree with a substantial research component.
Please refer to the research degree entry pathways page for further information.
How to apply
Interested applicants should email their CV and academic transcript to Prof Tania De Koning-Ward.
Applicants invited to submit a full application should follow the instructions on our How to Apply page.
For more information about this scholarship, please contact Prof Tania De Koning-Ward
Prof Tania De Koning-Ward
Email Tania De Koning-Ward
+61 3 522 72923