Designing Clinical Trials
Tuesday 30 April 2019, 10am to 4pm, Burwood Corporate Centre
A sound study design is of vital importance when conducting your research. Choices made at the design stage will drastically impact the results of your study. A design that has been thought through to the last detail and is perfectly aligned with your research aims will have a better chance of producing useful evidence.
During the morning we will discuss in practical terms the fundamental elements to be considered in the planning and execution of controlled clinical trials designed to evaluate biomedical, behavioural or community interventions. Topics will include: target population definition, outcome/endpoint selection and measurement, randomization methods, blinding of intervention, bias, attrition and post-randomization problems. The effect of features such as power, generalizability, validity, practicality and cost on the evidence provided by a trial will be discussed.
Using examples we will illustrate different types of designs including: completely and clustered randomized designs, cross-over and parallel designs, one-way and factorial designs, fixed and adaptive designs. We will also discuss the relative merits and feasibility of each approach. The close relationship between design and statistical analysis plan will be emphasized.
During the afternoon we will discuss real research questions posed by some of the participants. Those participants who want to volunteer will have the opportunity to present their research question and their proposed study designs which strengthens, weakness and feasibility will be discussed as case studies.
Who should attend?
PhD students and early career researchers within the Faculty of Health planning to conduct a clinical trial or a community intervention in order to answer their research questions.
Liliana Orellana, PhD, Associate Professor of Biostatistics
Please note: courses may be subject to cancellation if insufficient number of participants have registered.