ITRI

Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)

BioDeakin staff profiles

Aprof Christophe Lefevre

Position: Associate Professor Bioinformatics
Phone: +61 3 522 72037
Email: christophe.lefevre@deakin.edu.au
Campus: G


 

Research interests:

Recently the genome sequences of a rapidly growing number of organisms have become available. The comparisons of these genomes yield tremendous insights into the genes that are essential for life and those that define the species, revealing the mechanisms of evolution and the hidden mechanisms of gene regulation. The rich mammalian diversity found in Australia provides a unique resource to study the evolution of lactation. The Mammosapiens project is employing high throughput biotechnologies for the study of lactation in mammals with extreme lactation strategies. A bioinformatics resource is used to support storage and analysis of the data generated.

Qualifications:

  • Bachelor of Science (Biology), University of Tours, 1981
  • PhD (Biochemistry), University of Montpellier, 1984

Relevant employment history:

2008-current: Assoc Prof of Bioinformatics, Institute for Technology Research and Innovation, Deakin University, Australia.
2003-2007: Senior Research Scientist, Victorian Bioinformatics Consortium, Monash University, and Melbourne University, Melbourne, Australia.
2000-2002: System Software Development Manager, Molecular Design and Informatics, Organon, the Netherlands.
1996-1999: Bioinformaticien, Gentech, Sophia Antipolis, France.
1990-1995: Visiting Scientist, Genosphere Project IGSP/ERATO, Tohkai University, Japan.
1987-1990: Adjunct assistant Prof, UCLA School of Medicine, Cedars-Sinai Medical Center, LA.
1986-87: Research Associate, Department of Mathematics, Department of Molecular Biology, University of Southern California, Los Angeles.
1984-86: Postdoc., Department of Pharmacology, University of California of San Diego, LA
1982-83: Graduate teaching assistant, Dept. of Biochemistry, Centre National de la Recherche Scientifique, France;
1981-84: Graduate research assistant, Dept. of Biochemistry, Université de Montpellier, France.

A list of the ten most significant relevant publications for the last five years:

  1. Lack of functional alpha-lactalbumin prevents involution in Cape fur seals and identifies the protein is an apoptotic milk factor in mammary gland involution. Julie A. Sharp, Christophe Lefevre, and Kevin R. Nicholas. BMC Biology, 2008, 6:48.
  2. MammoSapiens: eResearch of the lactation program. Building online facilities for collaborative molecular and evolutionary analysis of lactation and other biological systems from gene sequences and gene expression data. Kevin R Nicholas, Amit Kumar, Yvan Strahm, David Powell, Amelia Brennan, Karensa Menzies, Julie Sharp, Matthew Digby, Christophe Lefèvre. eResearch Australasia 2008 conference. Winner of the Victorian eResearch Strategic Initiative (VeRSI) Award in science (http://www.scienceinpublic.com/new_page_2.htm ).
  3. Uncoupling the mechanisms that facilitate cell survival in hormone-derived bovine mammary explants. Brennan A, Sharp J, Lefevre C, Nicholas K. J Mol Endocrinol. 2008 Sep;41(3):103-16. Epub 2008 Jun 5. PMID: 18535120.
  4. Genome analysis of the platypus reveals unique signatures of evolution. Wesley C. Warren, et al. Nature. 2008 May 8;453(7192):175-83.
  5. RNA Expression Microarray Analysis in Mouse Prospermatogonia: Identification of Candidate Epigenetic Modifiers. Christophe Lefevre and Jeffrey R. Mann. Dev Dyn. 2008 Apr; 237(4):1082-9.
  6. Lactation transcriptomics in the Australian marsupial, Macropus eugenii: transcript sequencing and quantification. Christophe M. Lefevre, Matthew
  7. R. Digby, Jane C. Whitley, Yvan Strahm, Kevin R. Nicholas. BMC Genomic, 2007 Nov 13;8:417. PMID: 17997866.
  8. EST-PAC a web package for EST annotation and protein sequence prediction.
  9. Yvan Strahm, David Powell, Christophe Lefevre. Source Code Biol Med. 2006 Oct 12;1:2.
  10. Molecular evolution of Monotreme and marsupial whey acidic protein genes. Julie Anne Sharp, Christophe Lefevre, Kevin R Nicholas. Evol Dev. 2007 Jul-Aug;9(4):378-92.
  11. Reconstruction of Protein-Protein Interaction Pathways by Mining Subject-
  12. Verb-Objects Intermediates. Maurice HT Ling, Christophe Lefevre, Kevin R. Nicholas, Feng Lin. 2nd IAPR Workshop on Pattern Recognition in Bioinformatics (PRIB 2007). (2007). Lecture Notes in Computer Science Publisher: Springer Berlin / Heidelberg, Vol. 4774/2007, Pattern Recognition in Bioinformatics. ISBN 978-3-540-75285-1. Vol. 4774/2007, 286-299.
  13. A population of mammary epithelial cells do not require hormones or growth factors to survive. Brennan AJ, Sharp JA, Khalil E, Digby MR, Mailer SL, Lefevre CM, Nicholas KR. J Endocrinol. 2008 Mar; 196(3):483-96.

University recorded publications

Researcher output profile for Aprof Christophe Lefevre

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16th June 2011