Dr Dichtl’s did his PhD studies at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany and at the University of Edinburgh, Scotland working on the molecular toxicity of lithium and the processing of ribosomal RNA and transfer RNA precursors. Supported by an EMBO long-term fellowship he then took up post-doctoral work at the Biocenter, in Basel Switzerland where he studied the mechanisms of pre-mRNA polyadenylation and transcription termination. A highly competitive and prestigious Foerderprofessur grant of the Swiss National Science Foundation (SNF) allowed him to establish his own research group at the Institute of Molecular Life Sciences, University of Zurich, Switzerland. There, he expanded his research activities to the analyses of chromatin modifying enzymes and the assembly of multi-protein complexes. Dr Dichtl’s laboratory relocated to Deakin University at the end of 2010. In 2014 he won an ARC Discovery Project grant to study the mechanisms of protein complex formation.
1) The role and regulation of alternative polyadenylation in health and disease.
Pre-mRNA 3’ end formation is an essential RNA maturation step that impacts on virtually all aspects of mRNA function. The process adds a tail of approximately 250 adenosines to the 3’ end of mRNA and determines the length of the 3’ Un-Translated Region (3’UTR), which is targeted by a large number of regulatory factors. Control of 3’UTR length via alternative Polyadenylation (APA) is an important mechanism to control gene expression. We are interested in the regulation of APA and how it is integrated with cellular signaling pathways.
2) The function and regulation of the Set1C histone methyltransferase.
Histone modifying enzymes regulate diverse processes that occur in association with chromatin. We performed extensive yeast two-hybrid screening in order to identify novel cellular roles for the Set1C chromatin-modifying enzyme. This resulted in a recent publication in Science (Acquaviva et al., 2013), where we identified the molecular mechanisms, which link chromatin modification of histone H3 lysine 4 to the formation of double strand DNA breaks, to initiate the process of meiotic recombination.
3) Co-translational protein complex formation.
Multi-protein complexes constitute some of the most relevant molecular units of cellular function. Despite their important role it remains mysterious how eukaryotic cells manage to assemble with precision hundreds of different complexes in the crowded cytoplasmic compartment that produces thousands of nascent proteins at the same time. Recently published work from our laboratory demonstrated that assembly of protein complexes can be initiated on nascent proteins as they emerge from the ribosome (Halbach et al, 2009). We are currently investigating the functional significance of co-translational protein interactions.
SLE212 Biochemistry (Campus Coordinator)
SLE222 Biochemical Metabolism (Unit chair)
Several exiting Honours projects as well as SLE314 Research projects are available in my lab! Please write me an email if you would like to have a chat about those projects!
Laurent Acquaviva, Lorant Szekvolgyi, Dr Bernhard Dichtl, Dr Beatriz Dichtl, Christophe de la roche Saint Andre, Alain Nicolas, Vincent Geli
(2013), Vol. 339, pp. 215-218, Science, Washington, D.C., C1
Lilit Atanesyan, Viola Gunther, Dr Bernhard Dichtl, Oleg Georgiev, Walter Schaffner
(2012), Vol. 393, pp. 63-70, Biological chemistry, Berlin, Germany, C1-1
Sandra Holbein, Simonetta Scola, Bernhard Loll, Dr Beatriz Dichtl, Wolfgang Hubner, Anton Meinhart, Dr Bernhard Dichtl
(2011), Vol. 6, pp. 1-10, PLoS One, San Francisco, Calif, C1-1
Ross D. Alexander, J. David Barrass, Dr Beatriz Dichtl, Martin Kos, Tomasz Obtulowicz, Marie-Cecile Robert, Michal Koper, Iwona Karkusiewicz, Luisa Mariconti, David Tollervey, Dr Bernhard Dichtl, Joanna Kufel, Edouard Bertrand, Jean D. Beggs
(2010), Vol. 16, pp. 2570-2580, RNA, Woodbury, N.Y., C1-1
Luisa Mariconti, Bernhard Loll, Karola Schlinkmann, Agnieszka Wengi, Anton Meinhart, Dr Bernhard Dichtl
(2010), Vol. 16, pp. 2205-2217, RNA, Woodbury, N.Y., C1-1
Sandra Holbein, Agnieszka Wengi, Laurence Decourty, Florian M. Freimoser, Alain Jacquier, Dr Bernhard Dichtl
(2009), Vol. 15, pp. 837-849, RNA, Woodbury, N.Y., C1-1
Andre Halbach, Haidi Zhang, Agnieszka Wengi, Zofia Jablonska, Isabel M. Gruber., Regula E. Halbeisen, Pierre-Marie Dehe, Patrick Kemmeren, Frank Holstege, Vincent Geli, Andre P. Gerber, Dr Bernhard Dichtl
(2009), Vol. 28, pp. 2959-2970, Embo Journal, London, England, C1-1
Monika Garas, Dr Bernhard Dichtl, Walter Keller
(2008), Vol. 14, pp. 2671-2684, RNA, Woodbury, N.Y., C1-1
Sandra Holbein, Florian M. Freimoser, Thomas P. Werner, Agnieszka Wengi, Dr Bernhard Dichtl
(2008), Vol. 36, pp. 353-363, Nucleic acids research, Oxfird, England, C1-1
Pierre-Marie Dehe, Dr Bernhard Dichtl, Daniel Schaft, Assen Roguev, Merce Pamblanco, Regine Lebrun, Alfonso Rodriguez-Gil, Msau Mkandawire, Katarina Landsberg, Anna Shevchenko, Andrej Shevchenko, Lorena E. Rosaleny, Vicente Tordera, Sebastian Chavez, Vincent Geli
(2006), Vol. 281, pp. 35404-35412, Journal of biological chemistry, Baltimore, Md, C1-1
Mariangela Morlando, Monica Ballarino, Paolo Greco, Elisa Caffarelli, Dr Bernhard Dichtl, Irene Bozzoni
(2004), Vol. 23, pp. 2392-2401, EMBO journal, London, England, C1-1
Dr Bernhard Dichtl, Rein Aasland, Walter Keller
(2004), Vol. 10, pp. 965-977, RNA, Woodbury, N. Y., C1-1
Martin Sadowski, Dr Bernhard Dichtl, Wolfgang Hubner, Walter Keller
(2003), Vol. 22, pp. 2167-2177, EMBO journal, London, England, C1-1
Andrea Kyburz, Martin Sadowski, Dr Bernhard Dichtl, Walter Keller
(2003), Vol. 31, pp. 3936-3945, Nucleic acids research, Oxford, England, C1-1
Mariangela Morlando, Paolo Greco, Dr Bernhard Dichtl, Alessandro Fatica, Walter Keller, Irene Bozzoni
(2002), Vol. 22, pp. 1379-1389, Molecular and cellular biology, Washington, D. C., C1-1
Dr Bernhard Dichtl, Diana Blank, Martin Ohnacker, Arno Friedlein, Daniel Roeder, Hanno Langen, Walter Keller
(2002), Vol. 10, pp. 1139-1150, Molecular cell, Cambridge, Mass., C1-1
Dr Bernhard Dichtl, Diana Blank, Martin Sadowski, Wolfgang Hubner, Stefan Weiser, Walter Keller
(2002), Vol. 21, pp. 4125-4135, EMBO journal, London, C1-1
Dr Bernhard Dichtl, Walter Keller
(2001), Vol. 20, pp. 3197-3209, EMBO journal, London, England, C1-1
Joanna Kufel, Dr Bernhard Dichtl, David Tollervey
(1999), Vol. 5, pp. 909-917, RNA, Woodbury, N. Y., C1-1
Dr Bernhard Dichtl, Audrey Stevens, David Tollervey
(1997), Vol. 16, pp. 7184-7195, EMBO journal, London, England, C1-1
Dr Bernhard Dichtl, David Tollervey
(1997), Vol. 16, pp. 417-429, EMBO journal, London, England, C1-1
Tao Pan, Dr Bernhard Dichtl, Olke C. Uhlenbeck
(1994), Vol. 33, pp. 9561-9565, Biochemistry, Washington, D. C., C1-1
Dr Bernhard Dichtl, Tao Pan, Anthony B. di Renzo, Olke C. Uhlenbeck
(1993), Vol. 21, pp. 531-535, Nucleic acids research, Oxford, England, C1-1