A/Prof. Glenn Wadley

STAFF PROFILE

Position

Associate Professor

Faculty

Faculty of Health

Department

School of Exercise & Nut. Sci.

Campus

Melbourne Burwood Campus

Qualifications

Bachelor of Education, Deakin University, 1996
Bachelor of Applied Science (Human Movement), Deakin University, 1997
Master of Applied Science, Deakin University, 2000
Doctor of Philosophy, Deakin University, 2004
Graduate Certificate of Higher Education, Deakin University, 2012

Contact

glenn.wadley@deakin.edu.au
+61 3 924 46018

Research interests

Dr Wadleys research program has two major research streams centred on the impacts of physical activity and nutrition on adult health. The first stream examines the impacts of physical activity and the nutritional environments during early life on later adult health. The second research stream investigates exercise and antioxidant therapies for the treatment of type 2 diabetes and the regulation of mitochondrial biogenesis (synthesis) following exercise. Both of these topics have important implications for the treatment and prevention of type 2 diabetes and cardiovascular disease.

Affiliations

The Australian Physiological Society

Australian Diabetes Society

Australian Society for Medical Research

American Physiological Society
 

Teaching interests

School of Exercise and Nutrition Sciences, Higher Degrees by Research Coordinator

Graduate Certificate of Health Research Practice, Course Director

HSE303 Exercise Metabolism, Lecturer and Campus Chair (Burwood)

HSE201 Exercise Physiology, Lecturer

HBS400 Research Methods, Lecturer

HSE402/ HSN414 Honours Research Project, Lecturer

Primary supervisor of Honours students, two PhD students and Co-supervisor of two PhD students
 

Conferences

International (* presenting author) *Strobel NA, Peake JM, Matsumoto A, Marsh SA, Coombes JS, Wadley GD. 2008. ACSM: Integrative Physiology of Exercise, East Carolina. *Wadley GD and McConell GK. 2008. Experimental Biology. San Diego. *Laker RC, Siebel AL, Wadley GD, McConell GK and Wlodek ME. 2007. 5th International Congress on Developmental Origins of Health & Disease. Perth. Ross RM, Wadley GD, Clark MG, Rattigan S and McConell GK*. 2007. American Diabetes Association, 67th Scientific Meeting, Chicago. *Wadley G. and McConell GK. 2006. American College of Sports Medicine: Integrative Physiology of Exercise. Indianapolis. *Siebel AL, Wadley GD, Leone F, Cooney G, McConell GK, Owens JA and Wlodek ME. 2006. 10th International Conference on Obesity. Sydney. *Owens JA, Leone F, Siebel AL, Wadley GD, McConell GK, Cooney G and Wlodek ME. 2006. Society for Gynecologic Investigation, Toronto. National Invited presentations Wadley GD. 2010. Do antioxidant vitamin supplements really prevent the beneficial increase in skeletal muscle mitochondrial biogenesis following exercise training? AussieMit 2010; The Garvan Institute of Medical Research, Sydney. Wadley GD. 2009. Reactive oxygen species: friends or foes? Exercise, Muscle and Metabolism Conference, Melbourne. Wadley GD. 2008. Regulation of mitochondrial biogenesis in skeletal muscle during exercise by reactive oxygen species. AussieMit Workshop New Developments in Mitochondrial Research, LaTrobe University, Melbourne.

Awards

2016: Australian Awards for University Teaching - Citation for Outstanding  Contributions to Student Learning, Australian Government. For leadership in implementing a suite of active-learning approaches that have enhanced student learning in undergraduate physiology and in Honours research training.

2015: Vice Chancellor's Award for Teaching Excellence, Deakin University

2014: Award for Innovation in Teaching. Faculty of Health, Deakin University.

2004: National Heart Foundation of Australia Travel Grant

2000: National Heart Foundation of Australia Travel Grant

1999: Deakin University Postgraduate Research Scholarship

Publications

Filter by

2016

Maternal obesity in females born small: pregnancy complications and offspring disease risk

D Mahizir, J Briffa, D Hryciw, G Wadley, K Moritz, M Wlodek

(2016), Vol. 60, pp. 8-17, Molecular nutrition and food research, London, Eng., C1

journal

Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: findings of a randomized controlled study

S Mason, P Della Gatta, R Snow, A Russell, G Wadley

(2016), Vol. 93, pp. 227-238, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal

Endurance training in early life results in long-term programming of heart mass in rats

G Wadley, R Laker, G McConell, M Wlodek

(2016), Vol. 4, pp. 1-14, Physiological reports, London, Eng., C1

journal

Muscle redox signalling pathways in exercise. Role of antioxidants

S Mason, D Morrison, G McConell, G Wadley

(2016), Vol. 98, pp. 29-45, Free radical biology & medicine, Amsterdam, The Netherlands, C1

journal
2015

Modulating exercise-induced hormesis: does less equal more?

J Peake, J Markworth, K Nosaka, T Raastad, G Wadley, V Coffey

(2015), Vol. 119, pp. 172-189, Journal of applied physiology, Bethesda, Md., C1

journal

Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats

M Tran, M Young, A Jefferies, D Hryciw, M Ward, E Fletcher, M Wlodek, G Wadley

(2015), Vol. 3, pp. 1-9, Physiological reports, London, Eng., C1

journal

Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans

D Morrison, J Hughes, P Della Gatta, S Mason, S Lamon, A Russell, G Wadley

(2015), Vol. 89, pp. 852-862, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal
2014

High dose vitamin C supplementation increases skeletal muscle vitamin C concentration and SVCT2 transporter expression but does not alter redox status in healthy males.

S Mason, R Baptista, P Della Gatta, A Yousif, A Russell, G Wadley

(2014), Vol. 77, pp. 130-138, Free Radical Biology and Medicine, Amsterdam, The Netherlands, C1

journal

Skeletal muscle mitochondria: a major player in exercise, health and disease.

A Russell, V Foletta, R Snow, G Wadley

(2014), Vol. 1840, pp. 1276-1284, Biochimica et Biophysica Acta - General Subjects, Amsterdam , Netherlands, C1

journal

Growing healthy muscles to optimise metabolic health into adult life

S Bayol, C Bruce, G Wadley

(2014), Vol. 5, pp. 420-434, Journal of developmental origins of health and disease, Cambridge, United Kingdom, C1

journal

Growth restriction in the rat alters expression of cardiac JAK/STAT genes in a sex-specific manner.

S van der Linde, T Romano, G Wadley, A Jeffries, M Wlodek, D Hryciw

(2014), Vol. 5, pp. 314-321, Journal of developmental origins of health and disease, England, London, C1

journal

Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction

K Gatford, G Kaur, F Falcão-Tebas, G Wadley, M Wlodek, R Laker, P Ebeling, G McConell

(2014), Vol. 306, pp. E999-E1012, American journal of physiology - endocrinology and metabolism, Bethesda, MD, C1

journal

Skeletal muscle reactive oxygen species: a target of good cop/bad cop for exercise and disease

S Mason, G Wadley

(2014), Vol. 19, pp. 97-106, Redox report, Leeds, England, C1

journal

Altering the redox state of skeletal muscle by glutathione depletion increases the exercise-activation of PGC-1?

N Strobel, A Matsumoto, J Peake, S Marsh, T Peternelj, D Briskey, R Fassett, J Coombes, G Wadley

(2014), Vol. 2, pp. 1-10, Physiological reports, Malden, MA, C1

journal
2013

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

A Russell, S Wada, L Vergani, M Hock, S Lamon, B Léger, T Ushida, R Cartoni, G Wadley, P Hespel, A Kralli, G Soraru, C Angelini, T Akimoto

(2013), Vol. 49, pp. 107-117, Neurobiology of disease, Maryland Heights, Mo., C1

journal

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training

A Russell, A Russell, S Lamon, S Lamon, H Boon, H Boon, S Wada, S Wada, I Guller, I Guller, E Brown, E Brown, A Chibalin, A Chibalin, J Zierath, J Zierath, R Snow, R Snow, N Stepto, N Stepto, G Wadley, G Wadley, T Akimoto, T Akimoto

(2013), Vol. 591, pp. 4637-4653, Journal of physiology, Chichester, England, C1-1

journal

Growth restriction in the rat alters expression of metabolic genes during postnatal cardiac development in a sex specific manner

G Wadley, G McConell, C Goodman, A Siebel, K Westcott, M Wlodek

(2013), Vol. 45, pp. 99-105, Physiological genomics, Bethesda, Md., C1

journal

Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training.

G Wadley, M Nicolas, D Hiam, G McConell

(2013), Vol. 304, American journal of physiology - endocrinology and metabolism, Bethesda, Maryland, C1

journal
2012

Stage of perinatal development regulates skeletal muscle mitochondrial biogenesis and myogenic regulatory factor genes with little impact of growth restriction or cross-fostering

R Laker, G Wadley, G McConell, M Wlodek

(2012), Vol. 3, pp. 39-51, Journal of development origins of health and disease, Cambridge, England, C1

journal

Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1? in adulthood

R Laker, M Wlodek, G Wadley, L Gallo, P Meikle, G McConell

(2012), Vol. 302, AJP: Endocrinology and Metabolism, Bethesda, Md., C1

journal

Skeletal muscle nitric oxide signalling and exercise: a focus on glucose metabolism

G McConell, S Rattigan, R Lee-Young, G Wadley, T Merry

(2012), Vol. 303, American journal of physiology, endocrinology and metabolism, Bethesda, Maryland, C1-1

journal

Effect of pregnancy for females born small on later life metabolic disease risk

M Tran, L Gallo, G Wadley, A Jefferies, K Moritz, M Wlodek

(2012), Vol. 7, pp. 1-8, PLOS ONE, San Francisco, California, C1-1

journal

Short-term intensified cycle training alters acute and chronic responses of PGC1? and cytochrome C oxidase IV to exercise in human skeletal muscle

N Stepto, B Benziane, G Wadley, A Chibalin, B Canny, N Eynon, G McConell

(2012), Vol. 7, pp. 1-11, PLOS ONE, San Francisco, California, C1-1

journal
2011

Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis

N Strobel, J Peake, A Matsumoto, S Marsh, J Coombes, G Wadley

(2011), Vol. 43, pp. 1017-1024, Medicine and science in sports and exercise, Philadelphia, P. A., C1

journal

Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats

R Laker, L Gallo, M Wlodek, A Siebel, G Wadley, G McConell

(2011), Vol. 301, pp. 931-940, AJP : endocrinology and metabolism, Bethesda, Md., C1

journal

Effect of L-arginine infusion on glucose disposal during exercise in humans

K Linden, G Wadley, A Garnham, G McConell

(2011), Vol. 43, pp. 1626-1634, Medicine and science in sports and exercise, Philadelphia, Pa., C1

journal

Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep

R Laker, B Henry, G Wadley, I Clarke, B Canny, G McConell

(2011), Vol. 300, pp. 511-518, American journal of physiology : regulatory, integrative and comparative physiology, Bethesda, Md., C1

journal
2010

High-dose antioxidant vitamin C supplementation does not prevent acute exercise-induced increases in markers of skeletal muscle mitochondrial biogenesis in rats

G Wadley, G McConell

(2010), Vol. 108, pp. 1719-1726, Journal of applied physiology, Bethesda, Md., C1

journal

N-Acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans

T Merry, G Wadley, C Stathis, A Garnham, S Rattigan, M Hargreaves, G McConell

(2010), Vol. 588, pp. 1623-1634, The Journal of Physiology, Oxford, England, C1

journal

Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes

G McConell, G Ng, M Phillips, Z Ruan, S Macaulay, G Wadley

(2010), Vol. 108, pp. 589-595, Journal of applied physiology, Bethesda, Md., C1-1

journal

Growth restriction before and after birth increases kinase signaling pathways in the adult rat heart

G Wadley, M Wlodek, G Ng, C Goodman, C Stathis, G McConell

(2010), Vol. 1, pp. 376-385, Journal of developmental origins of health and disease, Cambridge, England, C1

journal
2008

Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment

G McConell, A Manimmanakorn, R Lee-Young, B Kemp, K Linden, G Wadley

(2008), Vol. 105, pp. 1422-1427, Journal of applied physiology, Bethesda, Md., C1-1

journal

Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle

G McConell, G Wadley

(2008), Vol. 35, pp. 1488-1492, Clinical and experimental pharmacology and physiology, Oxford, England, C1-1

journal

Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex-specific manner in the adult rat

G Wadley, A Siebel, G Cooney, G McConell, M Wlodek, J Owens

(2008), Vol. 294, pp. 861-869, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

journal
2007

Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training.

G Wadley, N Konstantopoulos, L Macaulay, K Howlett, A Garnham, M Hargreaves, D Cameron-Smith

(2007), Vol. 102, pp. 1624-1631, Journal of applied physiology, Washington, D.C., C1-1

journal

NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle

G Wadley, J Choate, G McConell

(2007), Vol. 585, pp. 253-262, Journal of physiology, London, England, C1-1

journal

Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats

R Ross, G Wadley, M Clark, S Rattigan, G McConell

(2007), Vol. 56, pp. 2885-2892, Diabetes, New York, N. Y., C1-1

journal

Effect of nitric oxide synthase inhibition on mitochondrial biogenesis in rat skeletal muscle

G Wadley, G McConell

(2007), Vol. 102, pp. 314-320, Journal of applied physiology, Bethesda, Md., C1-1

journal
2006

Carbohydrate ingestion does not alter skeletal muscle AMPK signaling during exercise in humans

R Lee-Young, M Palmer, K Linden, K LePlastrier, B Canny, M Hargreaves, G Wadley, B Kemp, G McConell

(2006), Vol. 291, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

journal

Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans

G Wadley, R Lee-Young, B Canny, C Wasuntarawat, Z Chen, M Hargreaves, B Kemp, G McConell

(2006), Vol. 290, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

journal

L-Arginine infusion increases glucose clearance during prolonged exercise in humans

G McConell, N Huynh, R Lee-Young, B Canny, G Wadley

(2006), Vol. 290, American journal of physiology : endocrinology and metabolism, Bethesda, Md., C1-1

journal
2004

The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats

G Wadley, C Bruce, Nicky Konstantopoulos, S Macaulay, K Howlett, J Hawley, David Cameron-Smith

(2004), Vol. 47, pp. 412-419, Diabetologia, C1

journal
2003

UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects

A Russell, G Wadley, M Hesselink, G Schaart, S Lo, B Léger, A Garnham, E Kornips, D Cameron-Smith, J Giacobino, P Muzzin, R Snow, P Schrauwen

(2003), Vol. 445, pp. 563-569, Pfluegers Archiv : European journal of physiology, Berlin, Germany, C1

journal
2002

Exercise training increases lipid metabolism gene expression in human skeletal muscle

R Tunstall, K Mehan, G Wadley, G Collier, A Bonen, M Hargreaves, D Cameron-Smith

(2002), Vol. 283, pp. 66-72, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1

journal

Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity

A Russell, G Wadley, R Snow, J Giacobino, P Muzzin, A Garnham, D Cameron-Smith

(2002), Vol. 26, pp. 157-164, International journal of obesity: and related metabolic disorders, Hampshire, England, C1

journal

Slow component of VO2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity

A Russell, G Wadley, R Snow, J Giacobino, P Muzzin, A Garnham, D Cameron-Smith

(2002), Vol. 26, pp. 157-164, International journal of obesity, London, Eng., C1-1

journal
2001

Differential effects of exercise on insulin-signaling gene expression in human skeletal muscle.

G Wadley, R Tunstall, A Sanigorski, G Collier, M Hargreaves, D Cameron-Smith

(2001), Vol. 90, pp. 436-440, Journal of applied physiology, Bethesda, Md., C1

journal
1998

The relationship between repeated sprint ability and the aerobic and anaerobic energy systems

G Wadley, P Le Rossignol

(1998), Vol. 1, pp. 100-110, Journal of science and medicine in sport, Amsterdam, The Netherlands, C1-1

journal

Funded Projects at Deakin

Australian Competitive Grants

Improving glycaemic control in type 2 diabetes with vitamin C

A/Prof Glenn Wadley

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2016: $59,921

Supervisions

Principal Supervisor
2017

Yasmin Asif

Thesis entitled: Impact of exercise early in life on the adult heart

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2014

Shaun Mason

Thesis entitled: Treatment of Type 2 Diabetes with antioxidant vitamin C therapy

Doctor of Philosophy (Nutrition & Exercise) (Low Cost), School of Exercise and Nutrition Sciences

Associate Supervisor
2016

Evelyn Zacharewicz

Thesis entitled: The Role of MicroRNAs in Regulating Muscle Protein Synthesis

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences

2014

Isabelle Guller

Thesis entitled: MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells

Doctor of Philosophy (Nutrition & Exercise) (High Cost), School of Exercise and Nutrition Sciences