Dr Kirsten Howlett



Senior Lecturer In Exercise Physiology


Faculty of Health


School of Exercise & Nut. Sci.


Geelong Waurn Ponds Campus


Bachelor of Science, University of Melbourne, 1994
Doctor of Philosophy, University of Melbourne, 1998
Graduate Certificate of Higher Education, Deakin University, 2013


Research interests

Dr Howletts research program is focused on understanding the physiological, cellular and molecular responses to exercise. In particular, her research examines the underlying mechanisms which mediate the beneficial effects of exercise on skeletal muscle insulin action, and the translation of this for the treatment and prevention of insulin resistance and associated disorders.


Australian Physiological Society

Teaching interests

HSE201: Exercise Physiology
Supervisors and co-supervisors honours and PhD students


Fulbright Post-doctoral Award
The Queens Trust Award for Young Australians


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Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism

S Bond, K Howlett, G Kowalski, S Mason, T Connor, A Cooper, V Streltsov, C Bruce, K Walder, S McGee

(2017), Vol. 31, pp. 2592-2602, FASEB journal, Bethesda, Md., C1


Epigenetic regulation of skeletal muscle metabolism

K Howlett, S McGee

(2016), Vol. 130, pp. 1051-1063, Clinical science, London, Eng., C1


Plasma 25-hydroxyvitamin D level is related to protein signaling involved in glucose homeostasis in a tissue-specific manner

L Parker, I Levinger, A Mousa, K Howlett, B de Courten

(2016), Vol. 8, pp. 1-9, Nutrients, Basel, Switzerland, C1


Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

T Connor, S Martin, K Howlett, S McGee

(2015), Vol. 42, pp. 109-115, Clinical and Experimental Pharmacology and Physiology, England, London, C1


Exercise-induced muscle glucose uptake in mice with graded, muscle-specific GLUT-4 deletion

K Howlett, S Andrikopoulos, J Proietto, M Hargreaves

(2013), Vol. 1, pp. 1-7, Physiological reports, Chichester, England, C1


Akt, AS160, metabolic risk factors and aerobic fitness in middle-aged women

I Levinger, K Howlett, J Peake, A Garnham, D Hare, G Jerums, S Selig, C Goodman

(2010), Vol. 16, pp. 98-104, Exercise immunology review, Champaign, Ill., C1-1


Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1? in human skeletal muscle

M Gibala, S McGee, A Garnham, K Howlett, R Snow, M Hargreaves

(2009), Vol. 106, pp. 929-934, Journal of applied physiology, Bethesda, Md., C1


The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle

K Howlett, A Matthews, A Garnham, K Sakamoto

(2008), Vol. 294, pp. 401-407, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1


AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5

S McGee, B van Denderen, K Howlett, J Mollica, J Schertzer, B Kemp, M Hargreaves

(2008), Vol. 57, pp. 860-867, Diabetes, Alexandria, Va., C1-1


Effect of high-intensity intermittent swimming on post-exercise insulin sensitivity in rat epitrochlearis muscle

K Koshinaka, A Sano, K Howlett, T Yamazaki, M Sasaki, K Sakamoto, K Kawanaka

(2008), Vol. 57, pp. 749-756, Metabolism, Maryland Heights, Mo., C1-1


Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training.

G Wadley, N Konstantopoulos, L Macaulay, K Howlett, A Garnham, M Hargreaves, D Cameron-Smith

(2007), Vol. 102, pp. 1624-1631, Journal of applied physiology, Washington, D.C., C1-1


Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

K Howlett, K Sakamoto, A Garnham, D Cameron-Smith, M Hargreaves

(2007), Vol. 56, pp. 1608-1614, Diabetes, New York, N.Y., C1


Insulin-stimulated insulin recetor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise.

K Howlett, K Sakamoto, H Yu, L Goodyear, M Hargreaves

(2006), Vol. 55, pp. 1046-1052, Metabolism, Amsterdam, The Netherlands, C1


Exercise does not alter subcellular localization, but increases phosphorylation of insulin-signaling proteins in human skeletal muscle

C Wilson, M Hargreaves, K Howlett

(2006), Vol. 290, pp. 341-346, American journal of physiology: endocrinology and metabolism, Bethesda, Md., C1


The effect of insulin and exercise on c-Cbl protein abundance and phosphorylation in insulin-resistant skeletal muscle in lean and obese Zucker rats

G Wadley, C Bruce, Nicky Konstantopoulos, S Macaulay, K Howlett, J Hawley, David Cameron-Smith

(2004), Vol. 47, pp. 412-419, Diabetologia, C1


Exercise increases nuclear AMPK ?2 in human skeletal muscle

S McGee, K Howlett, R Starkie, D Cameron-Smith, B Kemp, M Hargreaves

(2003), Vol. 52, pp. 926-928, Diabetes, Alexandria, Va., C1


Regulation of glucose kinetics during intense exercise in humans: effects of ?- and ?-adrenergic blockade

K Howlett, M Watt, M Hargreaves, M Febbraio

(2003), Vol. 52, pp. 1615-1620, Metabolism, clinical and experimental, Philadelphia, Pa., C1


Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney

B Lamont, S Andrikopoulos, A Funkat, J Favaloro, J Ye, E Kraegen, K Howlett, J Zajac, J Proietto

(2003), Vol. 46, pp. 1338-1347, Diabetologia, New York, N.Y., C1


Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

K Howlett, K Sakamoto, M Hirschman, W Aschenbach, M Dow, M White, L Goodyear

(2002), Vol. 51, pp. 479-483, Diabetes, New York, N.Y., C1-1


Effect of AICAR treatment on gycogen metabolism in skeletal muscle

W Aschenbach, M Hirschman, N Fujii, K Sakamoto, K Howlett, L Goodyear

(2002), Vol. 51, pp. 567-573, Diabetes, New York, N.Y., C1-1


Effect of prior exercise on glucose metabolism in trained men.

A Rose, K Howlett, D King, M Hargreaves

(2001), Vol. 281, American journal of physiology : endocrinology and metabolism, Bethesada, Md., C1


Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans

M Watt, K Howlett, M Febbraio, L Spriet, M Hargreaves

(2001), Vol. 534, pp. 269-278, Journal of physiology, Cambrigde, England, C1


Carbohydrate metabolism during exercise in females : effect of reduced fat availability

K Howlett, L Spriet, M Hargreaves

(2001), Vol. 50, pp. 481-487, Metabolism, clinical and experimental, Duluth, Minn., C1


Splanchnic blood flow and hepatic glucose production in exercising humans : role of renin-angiotensin system

R Bergeron, M Kjaer, L Simonsen, J Bulow, D Skovgaard, K Howlett, H Galbo

(2001), Vol. 281, pp. 1854-1861, American journal of physiology. Regulatory, integrative, and comparative physiology, Bethesda, Md., C1-1


Adrenaline and glycogenolysis in skeletal muscle during exercise : a study in adrenalectomised humans

M Kjær, K Howlett, J Langfort, T Zimmerman-Belsing, J Lorentsen, J B?ülow, J Ihlemann, U Feldt-Rasmussen, H Galbo

(2000), Vol. 528, pp. 371-378, Journal of physiology, Oxford, England, C1-1


Glucose production during strenuous exercise in humans : role of epinephrine

K Howlett, M Febbraio, M Hargreaves

(1999), Vol. 276, American journal of physiology, Bethesda, Md., C1-1


Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans

K Howlett, H Galbo, J Lorentsen, R Bergeron, T Zimmerman-Belsing, J Bulow, U Feldt-Rasmussen, M Kjaer

(1999), Vol. 519, pp. 911-921, Journal of physiology, Oxford, England, C1-1


Effect of increased blood glucose availability on glucose kinetics during exercise

K Howlett, D Angus, J Proietto, M Hargreaves

(1998), Vol. 84, pp. 1413-1417, Journal of applied physiology, Bethesda, Md., C1-1


Effect of heat stress on glucose kinetics during exercise

M Hargreaves, D Angus, K Howlett, N Marmy Conus, M Febbraio

(1996), Vol. 81, pp. 1594-1597, Journal of applied physiology, Bethesda, Md., C1-1


Funded Projects at Deakin

Australian Competitive Grants

Intracellular localisation of insulin signalling proteins in human skeletal muscle following exercise

Dr Kirsten Howlett, Prof Mark Hargreaves

ARC - Discovery Projects

  • 2006: $58,561

A novel mechanism by which AMP-activated protein kinase (AMPK) may improve insulin action

Dr Kirsten Howlett

DART Grant - Research - Diabetes Australia - Victoria (Research Trust)

  • 2007: $24,900
  • 2006: $24,900


Associate Supervisor

Simon Bond

Thesis entitled: The Role of Glyceraldehyde-3-Phosphate Dehydrogenase Acetylation in Liver Metabolism

Doctor of Philosophy (Medicine), School of Medicine