Medical Research Future Fund Grants - submission via NHMRC Sapphire

The objectives of this grant opportunity are:

• to utilise clinical trials to promote Australian involvement in international collaborative investigator-initiated clinical trials research through the establishment and co-ordination of clinical trial site/s in Australia.
• provide high-quality evidence of the effectiveness of novel health treatments, drugs or devices in ‘usual care’ settings1, which will support a decision on whether to deliver the intervention in an Australian setting. Novel health treatments include new and innovative applications of existing interventions.

Applications to this grant opportunity must propose a single clinical trial in Australia in collaboration with international counterparts. The clinical trial should not have commenced recruitment at the Australian trial site/s.

The objective of this grant opportunity is provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• Stream 1 (Targeted Call for Research): identify and diagnose novel - primarily monogenic or oligogenic - rare diseases and increase the genomic diagnostic rate towards 70% by 2025.
• Stream 2 (Targeted Call for Research): improve early detection and targeted treatment for the most common cancers to reduce the burden of disease. Research proposals in this stream must focus on one of the following topics:
  - Topic A: discover clinically relevant biomarkers to improve early detection of common cancers
  - Topic B: develop genomic tools and technologies to identify genetic predisposition to cancer and improve screening and targeted intervention
  - Topic C: develop genomic screening tools for predictive disease modelling and to guide therapy.
• Stream 3 (Targeted Call for Research): promote diagnostic effectiveness and efficiency through better understanding of the impact of genetic variants through functional genomics by establishing a national functional genomics approach to enhance novel gene discoveries, increase diagnostic rates and enable disease modelling to support development of targeted therapies. All three Streams are intended to support large-scale interdisciplinary research.

The objective of this grant opportunity is to provide grants of financial assistance to support Australian medical research and medical innovation projects that:

• support proof-of-concept studies to establish the feasibility of novel stem cell-based therapies
• conduct Phase 1 clinical trials for promising stem cell treatments
• apply stem cell-based screens for the development of treatments for inherited disease, complex disease, infectious disease and cancer
• foster research on the ethical, social, regulatory, health economics and legal issues associated with the development, availability, regulation and application of stem cell therapies and treatments
• use stem cell-derived tissue models to rapidly screen TGA (and FDA) approved drugs as potential treatments for COVID-19.

The objective of this grant opportunity is to support Australian medical research and medical innovation projects that, develop novel interventions, including therapeutics and devices, to prevent cardiovascular disease and stroke; develop novel treatments and devices to improve outcomes; and conduct small-scale development projects to establish feasible, evidence-based approaches aimed at improving survivorship and reducing morbidity.

The intended outcome of the research is to improve the health and wellbeing of Australians by:

• Stream 1 (Targeted Call for Research): providing new therapeutics and devices that prevent cardiovascular disease and/or stroke
• Stream 2 (Targeted Call for Research): providing new interventions that promote rapid and more effective recovery following an acute cardiovascular disease and/or stroke event
• Stream 3 (Incubator): generating new approaches that have the potential to transform care following a cardiovascular and/or stroke event.

Applicants to this grant opportunity must propose research that addresses one of the three Streams of research. An application may be submitted to one of the above three Streams only. Applicants must specify the Stream to which they are applying in their application.

The objectives of the MRFF – TBI Mission – 2020 Traumatic Brain Injury Mission grant opportunity are outlined in the five Streams listed in the grant guidelines.

The intended outcome of the research is to improve the health and wellbeing of Australians by:

• Stream 1 (Incubator): supporting the development of more effective, evidence-based care for moderate to severe TBI through increased knowledge
• Stream 2 (Incubator): supporting health care providers to consistently deliver best practice treatment and care for moderate to severe TBI
• Stream 3 (Targeted Call for Research): reducing the extent of harm caused by  moderate to severe TBI by improving acute care practice
• Stream 4 (Incubator): supporting health care providers to consistently deliver best practice treatments and care for mild TBI
• Stream 5 (Targeted Call for Research): identifying strategies for improving community awareness of TBI and responses to people living with TBI.

Applicants to this grant opportunity must propose research that addresses one of the five Streams only. Applicants must specify the Stream to which they are applying in their application.

The objective of this opportunity is to accelerate the development of promising COVID-19 prophylactic (disease-preventing) vaccine candidates for which research and development is already underway. The prophylactic vaccine must be intended to induce active long-term immunity against COVID-19.

The vaccine candidate must have progressed beyond early or “developmental” stage research to pre-clinical or clinical investigation, and applicants must have already generated proof-of-concept data that supports pre-clinical or clinical development of the vaccine candidate.

Applicants must also demonstrate access to critical resources necessary to complete the project in the stipulated timeframes. This Grant Opportunity is not intended to support research programs that do not include optimisation or testing of COVID-19 prophylactic vaccine candidates.

The intended outcome of the research funded under this priority is to support rapid development of a safe and effective COVID-19 prophylactic (disease-preventing) vaccine, which induces active long-term immunity, within the next 12-18 months.

The objective of this grant opportunity is to support Australian medical research and medical innovation projects that will:

• identify an appropriate suite of measures that enable appraisal of local organisation and system performance to assess the impact of new care delivery models and quality improvement for people living with dementia
• develop interventions that deliver holistic and multidisciplinary care after diagnosis to improve quality of life for people living with dementia and their carers
• develop new and improved diagnostic and prognostic tools for dementia, including biological markers of disease onset and progression
• conduct research to understand and address barriers to effective infection control practices in aged care settings and during transitions.

The intended outcome of the research is to improve the health and wellbeing of Australians:

• Stream 1 (Targeted Call for Research (TCR)): living with dementia by supporting assessment and adoption of improved care delivery models
• Stream 2 (TCR): living with dementia and their carers by developing and supporting adoption of new patient centred care approaches
• Stream 3 (TCR): living with dementia by enabling earlier and more effective diagnosis and better understanding of disease progression
• Stream 4 (TCR): by reducing the incidence of infectious disease amongst residents in aged care settings and during transitions.

Applicants to this grant opportunity must propose research that addresses one of the four Streams of research. An application may be submitted to one of the above four Streams only.

The objective of this grant opportunity is to provide a grant of financial assistance to support a co-ordinated program of Victorian medical research and medical innovation projects aimed at improving outcomes for children with cancer by improving:

• basic knowledge about cancer in children
• the clinical management of cancer in children, including the patient journey and survivorship.

This grant opportunity will fund a multi-centre program of research that brings together expertise from the Melbourne Biomedical Precinct (Parkville) and the Monash Technology Precinct. The program must complement existing research programs and incorporate research activities based at The Royal Children’s Hospital, Melbourne and Monash Children’s Hospital.

The intended outcome of the research is to improve the health and wellbeing of Australians by facilitating research-informed, evidence-based continuous improvement in the care of children with cancer by seeding a high-impact program of paediatric cancer research that is amenable to, and competitive in, leveraging funding for further expansion.

The objective of the Medical Research Future Fund (MRFF) – Emerging Priorities and Consumer Driven Research (EPCDR) Initiative - 2020 Improving Diagnosis in Cancers with Low Survival Rates Grant Opportunity is to support Australian medical research and medical innovation projects in one of the following streams:

• Stream 1: utilise existing evidence to develop or improve approaches for the early diagnosis of ovarian cancer, cancers of the pancreas, liver cancer or lung cancer that have a clinically feasible pathway to implementation
• Stream 2: enable approaches for the early diagnosis of cancers with unknown primary site that have a clinically feasible pathway to implementation.

The intended outcome of the research is to improve the health and wellbeing of Australians by supporting research that improves the five-year relative survival rate for ovarian cancer, cancers of the pancreas, liver cancer, lung cancer and cancers with unknown primary site by enabling early diagnosis.

The objective of this grant opportunity is to support Aboriginal and/or Torres Strait Islander led medical research and medical innovation projects that:

• Stream 1 (Incubator): conduct small-scale developmental projects to establish teams and feasible, evidence-based approaches.
• Stream 2 (Targeted Call for Research): develop effective approaches for improving the quality, research capabilities and impact of interventions within primary health care.

Applicants must propose research that addresses one of the two Streams of research. An application may be submitted to one Stream only.

The MRFF – 2020 Neurofibromatosis Research Grant Opportunity will provide grants of financial assistance to support Australian medical research projects that:

• Stream 1: build knowledge of the factors that drive variation in the clinical presentation of neurofibromatosis for the purpose of generating new interventions
• Stream 2: use clinical trials to test the effectiveness of new interventions for the treatment of neurofibromatosis.

The intended outcome of the research is to improve the health and wellbeing of Australians by generating knowledge that will lead to new interventions that reduce the clinical impact of neurofibromatosis.

Please check specific MRFF scheme webpages for Guidelines, Proposal Templates and Peer Review information.

Applicants will need to register and log into GrantConnect to download the applicable documentation.

International Clinical Trial Collaborations; Click on GO Documents in GrantConnect

Genomics Health Futures Mission; Click on GO Documents in GrantConnect

Stem Cell Therapies Mission; Click on GO Documents in GrantConnect

Cardiovascular Health Mission; Click on GO Documents in GrantConnect

Traumatic Brain Injury Mission; Click on GO Documents in GrantConnect

COVID-19 Vaccine Candidate Research EOI (Rnd 3); Click on GO Documents in GrantConnect

Dementia, Ageing and Aged Care Mission; Click on GO Documents in GrantConnect

Paediatric Cancer; Click on GO Documents in GrantConnect

Improving Diagnosis in Cancers with Low Survival Rates; Click on GO Documents in GrantConnect

Indigenous Health Research; Click on GO Documents in GrantConnect

Neurofibromatosis Research; Click on GO Documents in GrantConnect

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