A/Prof. Amardeep Dhillon

STAFF PROFILE

Position

Associate Professor in Biomedical Sciences

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Contact

Publications

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2022

Generation and Characterization of a Zebrafish IL-2Rγc SCID Model

R Sertori, R Jones, F Basheer, L Rivera, S Dawson, S Loke, S Heidary, A Dhillon, C Liongue, A Ward

(2022), Vol. 23, International Journal of Molecular Sciences, C1

journal article
2021

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

A Chüeh, G Advani, M Foroutan, J Smith, N Ng, H Nandurkar, D Lio, H Zhu, Y Chong, H Verkade, D Fujita, J Bjorge, Faiza Basheer, J Lim, I Luk, A Dhillon, A Sakthianandeswaren, D Mouradov, O Sieber, F Hollande, J Mariadason, H Cheng

(2021), Vol. 40, pp. 3015-3029, Oncogene, London, Eng., C1

journal article

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

C Reehorst, R Nightingale, I Luk, L Jenkins, F Koentgen, D Williams, C Darido, F Tan, H Anderton, M Chopin, K Schoffer, M Eissmann, M Buchert, D Mouradov, O Sieber, M Ernst, A Dhillon, J Mariadason

(2021), Vol. 148, pp. 1-10, Development, Cambridge, Eng., C1

journal article
2019

Genomic profiling of biliary tract cancer cell lines reveals molecular subtypes and actionable drug targets

D Lau, D Mouradov, W Wasenang, I Luk, C Scott, D Williams, Y Yeung, T Limpaiboon, G Iatropoulos, L Jenkins, C Reehorst, F Chionh, M Nikfarjam, D Croagh, A Dhillon, A Weickhardt, T Muramatsu, Y Saito, N Tebbutt, O Sieber, J Mariadason

(2019), Vol. 21, pp. 624-637, iScience, Cambridge, Mass., C1

journal article
2018

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

Lars Tögel, Rebecca Nightingale, Rui Wu, Anderly Chüeh, Sheren Al-Obaidi, Ian Luk, Mercedes Dávalos-Salas, Fiona Chionh, Carmel Murone, Daniel Buchanan, Zac Chatterton, Oliver Sieber, Diego Arango, Niall Tebbutt, David Williams, Amardeep Dhillon, John Mariadason

(2018), Vol. 8, pp. 1-11, Scientific Reports, Berlin, Germany, C1

journal article
2017

ATF3 repression of BCL-XL determines apoptotic sensitivity to HDAC inhibitors across tumor types

A Chüeh, J Tse, M Dickinson, P Ioannidis, L Jenkins, L Togel, B Tan, I Luk, M Davalos-Salas, R Nightingale, M Thompson, B Williams, G Lessene, E Lee, W Fairlie, A Dhillon, J Mariadason

(2017), Vol. 23, pp. 5573-5584, Clinical Cancer Research, Denville, N.J., C1

journal article
2016

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

L Togel, R Nightingale, A Chueh, A Jayachandran, H Tran, T Phesse, R Wu, O Sieber, D Arango, A Dhillon, M Dawson, B Diez-Dacal, T Gahman, P Filippakopoulos, A Shiau, J Mariadason

(2016), Vol. 15, pp. 1217-1226, Molecular Cancer Therapeutics, Denville, N.J., C1

journal article
2015

FRA-1 as a driver of tumour heterogeneity: A nexus between oncogenes and embryonic signalling pathways in cancer

A Dhillon, E Tulchinsky

(2015), Vol. 34, pp. 4421-4428, Oncogene, C1-1

journal article

Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer

L Pereira, L Pereira, J Mariadason, J Mariadason, R Hannan, R Hannan, A Dhillon, A Dhillon

(2015), Vol. 5, Frontiers in Oncology, C1

journal article

A novel role for the pol I transcription factor ubtf in maintaining genome stability through the regulation of highly transcribed pol II genes

E Sanij, E Sanij, J Diesch, J Diesch, A Lesmana, A Lesmana, G Poortinga, G Poortinga, N Hein, N Hein, G Lidgerwood, G Lidgerwood, D Cameron, D Cameron, J Ellul, J Ellul, G Goodall, G Goodall, L Wong, L Wong, A Dhillon, A Dhillon, N Hamdane, N Hamdane, L Rothblum, L Rothblum, R Pearson, R Pearson, I Haviv, I Haviv, R Hannan, R Hannan

(2015), Vol. 25, pp. 201-212, Genome Research, C1

journal article

Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

G Advani, G Advani, A Chueh, A Chueh, Y Lim, Y Lim, A Dhillon, A Dhillon, H Cheng, H Cheng

(2015), Vol. 10, pp. 195-202, Frontiers in Biology, C1

journal article

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

O Gilan, J Diesch, M Amalia, K Jastrzebski, A Chueh, N Verrills, R Pearson, J Mariadason, E Tulchinsky, R Hannan, A Dhillon

(2015), Vol. 34, pp. 1333-1339, Oncogene, C1-1

journal article
2014

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like Factor 5 (KLF5)-defendent manner

J Shin, J Shin, A Carr, A Carr, G Corner, G Corner, L Tögel, L Tögel, M Dávaos-Salas, M Dávaos-Salas, H Tran, H Tran, A Chueh, A Chueh, S Al-Obaidi, S Al-Obaidi, F Chionh, F Chionh, N Ahmed, N Ahmed, D Buchanan, D Buchanan, J Young, J Young, M Malo, M Malo, R Hodin, R Hodin, D Arango, D Arango, O Sieber, O Sieber, L Augenlicht, L Augenlicht, A Dhillon, A Dhillon, T Weber, T Weber, J Mariadason, J Mariadason

(2014), Vol. 289, pp. 25306-25316, Journal of Biological Chemistry, C1-1

journal article

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

J Diesch, E Sanij, O Gilan, C Love, H Tran, N Fleming, J Ellul, M Amalia, I Haviv, R Pearson, E Tulchinsky, J Mariadason, O Sieber, R Hannan, A Dhillon

(2014), Vol. 9, PLoS ONE, C1-1

journal article
2012

A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells

J Pakay, J Pakay, J Diesch, J Diesch, O Gilan, O Gilan, Y Yip, Y Yip, E Sayan, E Sayan, W Kolch, W Kolch, J Mariadason, J Mariadason, R Hannan, R Hannan, E Tulchinsky, E Tulchinsky, A Dhillon, A Dhillon

(2012), Vol. 31, pp. 1817-1824, Oncogene, C1

journal article

Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL

A Sayan, R Stanford, R Vickery, E Grigorenko, J Diesch, K Kulbicki, R Edwards, R Pal, P Greaves, I Jariel-Encontre, M Piechaczyk, M Kriajevska, J Mellon, A Dhillon, E Tulchinsky

(2012), Vol. 31, pp. 1493-1503, Oncogene, C1-1

journal article
2010

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

Y Yeap, I Ng, B Badrian, T Nguyen, Y Yip, A Dhillon, S Mutsaers, J Silke, M Bogoyevitch, D Ng

(2010), Vol. 430, pp. 345-354, Biochemical Journal, C1-1

journal article
2009

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

A Dhillon, Y Yip, G Grindlay, J Pakay, M Dangers, M Hillmann, W Clark, A Pitt, H Mischak, W Kolch

(2009), Vol. 21, pp. 1645-1651, Cellular Signalling, C1-1

journal article
2008

Snail is a repressor of RKIP transcription in metastatic prostate cancer cells

S Beach, H Tang, S Park, A Dhillon, E Keller, W Kolch, K Yeung

(2008), Vol. 27, pp. 2243-2248, Oncogene, C1-1

journal article
2007

MAP kinase signalling pathways in cancer

A Dhillon, S Hagan, O Rath, W Kolch

(2007), Vol. 26, pp. 3279-3290, Oncogene, C1-1

journal article

Phosphatase and feedback regulation of Raf-1 signaling

A Dhillon, A Von Kriegsheim, J Grindlay, W Kolch

(2007), Vol. 6, pp. 3-7, Cell Cycle, C1-1

journal article
2006

Raf Kinase Inhibitor Protein Regulation of Raf and MAPK Signaling

S Hagan, R Garcia, A Dhillon, W Kolch

(2006), Vol. 407, pp. 248-259, Methods in Enzymology, B1-1

book chapter

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

A von Kriegsheim, A Pitt, G Grindlay, W Kolch, A Dhillon

(2006), Vol. 8, pp. 1011-1016, Nature Cell Biology, C1-1

journal article
2005

Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells

C Pollock, S Shirasawa, T Sasazuki, W Kolch, A Dhillon

(2005), Vol. 65, pp. 1244-1250, Cancer Research, C1-1

journal article
2004

Dystroglycan, a scaffold for the ERK-MAP kinase cascade

H Spence, A Dhillon, M James, S Winder

(2004), Vol. 5, pp. 484-489, EMBO Reports, C1-1

journal article
2003

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation

A Dhillon, S Meikle, C Peyssonnaux, J Grindlay, C Kaiser, H Steen, P Shaw, H Mischak, A Eychène, W Kolch

(2003), Vol. 23, pp. 1983-1993, Molecular and Cellular Biology, C1-1

journal article
2002

Regulation of Raf-1 activation and signalling by dephosphorylation

A Dhillon, S Meikle, Z Yazici, M Eulitz, W Kolch

(2002), Vol. 21, pp. 64-71, EMBO Journal, C1-1

journal article

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259

A Dhillon, C Pollock, H Steen, P Shaw, H Mischak, W Kolch

(2002), Vol. 22, pp. 3237-3246, Molecular and Cellular Biology, C1-1

journal article
2001

Alcoholic myopathy: Biochemical mechanisms

V Preedy, A Paice, D Mantle, A Dhillon, T Palmer, T Peters

(2001), Vol. 63, pp. 199-205, Drug and Alcohol Dependence, C1-1

journal article

Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κB activation

K Yeung, D Rose, A Dhillon, D Yaros, M Gustafsson, D Chatterjee, B McFerran, J Wyche, W Kolch, J Sedivy

(2001), Vol. 21, pp. 7207-7217, Molecular and Cellular Biology, C1-1

journal article
2000

Intact mitochondrial electron transport function is essential for signalling by hydrogen peroxide in cardiac myocytes

M Bogoyevitch, D Ng, N Court, K Draper, A Dhillon, L Abas

(2000), Vol. 32, pp. 1469-1480, Journal of Molecular and Cellular Cardiology, C1-1

journal article
1998

Alcohol-related diols cause acute insulin resistance in vivo

D Xu, A Dhillon, A Abelmann, K Croft, T Peters, T Palmer

(1998), Vol. 47, pp. 1180-1186, Metabolism: Clinical and Experimental, C1-1

journal article
1996

Metabolic effects of alcohol on skeletal muscle

D Xu, A Dhillon, T Palmer

(1996), Vol. 1, pp. 143-155, Addiction Biology, C1-1

journal article

Acute ethanol-mediated insulin resistance in the rat: The role of ethanol oxidation

A Dhillon, D Xu, T Palmer

(1996), Vol. 1, pp. 427-435, Addiction Biology, C1-1

journal article

Alcohol and glucose metabolism in skeletal muscles in the rat

D Xu, A Dhillon, C Davey, P Fournier, T Palmer

(1996), Vol. 1, pp. 71-83, Addiction Biology, C1-1

journal article

The transition from lipid to carbohydrate oxidation in response to re- feeding after starvation

D Xu, A Dhillon, P Drake, T Palmer

(1996), Vol. 16, pp. 1545-1553, Nutrition Research, C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

Transcriptional Effectors of Oncogenic ERK Signaling in Colorectal Cancer

A/Prof Amardeep Dhillon, Prof John Mariadason, A/Prof Niall Tebbutt

NHMRC Project Grant

  • 2021: $217,142
  • 2020: $134,152
  • 2019: $194,187
  • 2018: $109,033

Supervisions

Principal Supervisor
2020

Afrah Jalil Abd Al-Juhaishi

Thesis entitled: Novel nanoformulations to ameliorate aged macular degeneration in mammalian models

Doctor of Philosophy (Medicine), School of Medicine