A/Prof. Amardeep Dhillon

Genotype-Tailored ERK/MAPK Pathway and HDAC Inhibition Rewires the Apoptotic Rheostat to Trigger Colorectal Cancer Cell Death

L Jenkins, I Luk, W Fairlie, E Lee, M Palmieri, K Schoffer, T Tan, I Ng, N Vukelic, S Tran, J Tse, R Nightingale, Z Alam, F Chionh, G Iatropoulos, M Ernst, S Afshar-Sterle, J Desai, P Gibbs, O Sieber, A Dhillon, N Tebbutt, J Mariadason

(2023), Vol. 22, pp. 52-62, Molecular cancer therapeutics, United States, C1

N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection

S Ameen, Nane Griem-Krey, Antoine Dufour, M Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik Draxler, Robert Medcalf, Mohd Kamaruddin, Isabelle Lucet, Michael Leeming, Dazhi Liu, Amardeep Dhillon, Jet Lim, Faiza Basheer, Hong-Jian Zhu, Laita Bokhari, Carli Roulston, Prasad Paradkar, Oded Kleifeld, Andrew Clarkson, Petrine Wellendorph, Giuseppe Ciccotosto, Nicholas Williamson, Ching-Seng Ang, Heung-Chin Cheng

(2023), pp. 1-27, Molecular and Cellular Proteomics, Bethesda, Md., C1

Intestinal-specific Hdac3 deletion increases susceptibility to colitis and small intestinal tumour development in mice fed a high fat diet.

Irvin Ng, Ian Luk, Rebecca Nightingale, Camilla Reehorst, Mercedes Davalos-Salas, Laura Jenkins, Chun Fong, David Williams, Matthew Watt, Amardeep Dhillon, John Mariadason

(2023), pp. 1-27, American Journal of Physiology-Gastrointestinal and Liver Physiology, Bethesda, Md., C1

Generation and Characterization of a Zebrafish IL-2Rγc SCID Model

R Sertori, R Jones, F Basheer, L Rivera, S Dawson, S Loke, S Heidary, A Dhillon, C Liongue, A Ward

(2022), Vol. 23, pp. 1-13, International Journal of Molecular Sciences, Basel, Switzerland, C1

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression

I Luk, L Jenkins, K Schoffer, I Ng, J Tse, D Mouradov, S Kaczmarczyk, R Nightingale, A Burrows, R Anderson, D Arango, H Dopeso, L Croft, M Richardson, O Sieber, Y Liao, J Mooi, N Vukelic, D Williams, A Dhillon

(2022), Vol. 29, pp. 2288-2302, Cell Death and Differentiation, London, Eng., C1

Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish

K Kubra, G Gaddu, C Liongue, S Heidary, A Ward, A Dhillon, F Basheer

(2022), Vol. 23, International Journal of Molecular Sciences, Switzerland, C1

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

A Chüeh, G Advani, M Foroutan, J Smith, N Ng, H Nandurkar, D Lio, H Zhu, Y Chong, H Verkade, D Fujita, J Bjorge, F Basheer, J Lim, I Luk, A Dhillon, A Sakthianandeswaren, D Mouradov, O Sieber, F Hollande, J Mariadason, H Cheng

(2021), Vol. 40, pp. 3015-3029, Oncogene, England, C1

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

C Reehorst, R Nightingale, I Luk, L Jenkins, F Koentgen, D Williams, C Darido, F Tan, H Anderton, M Chopin, K Schoffer, M Eissmann, M Buchert, D Mouradov, O Sieber, M Ernst, A Dhillon, J Mariadason

(2021), Vol. 148, Development (Cambridge), England, C1

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

D Lau, D Mouradov, W Wasenang, I Luk, C Scott, D Williams, Y Yeung, T Limpaiboon, G Iatropoulos, L Jenkins, C Reehorst, F Chionh, M Nikfarjam, D Croagh, A Dhillon, A Weickhardt, T Muramatsu, Y Saito, N Tebbutt, O Sieber, J Mariadason

(2019), Vol. 21, pp. 624-637, iScience, United States, C1

DUSP5 is methylated in CIMP high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis

L Tögel, R Nightingale, R Wu, A Chüeh, S Al-Obaidi, I Luk, M Dávalos-Salas, F Chionh, C Murone, D Buchanan, Z Chatterton, O Sieber, D Arango, N Tebbutt, D Williams, A Dhillon, J Mariadason

(2018), Vol. 8, Scientific Reports, England, C1

ATF3 repression of BCL-XL determines apoptotic sensitivity to HDAC inhibitors across tumor types

A Chüeh, J Tse, M Dickinson, P Ioannidis, L Jenkins, L Togel, B Tan, I Luk, M Davalos-Salas, R Nightingale, M Thompson, B Williams, G Lessene, E Lee, W Fairlie, A Dhillon, J Mariadason

(2017), Vol. 23, pp. 5573-5584, Clinical Cancer Research, United States, C1

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

L Togel, R Nightingale, A Chueh, A Jayachandran, H Tran, T Phesse, R Wu, O Sieber, D Arango, A Dhillon, M Dawson, B Diez-Dacal, T Gahman, P Filippakopoulos, A Shiau, J Mariadason

(2016), Vol. 15, pp. 1217-1226, Molecular Cancer Therapeutics, Denville, N.J., C1

FRA-1 as a driver of tumour heterogeneity: A nexus between oncogenes and embryonic signalling pathways in cancer

A Dhillon, E Tulchinsky

(2015), Vol. 34, pp. 4421-4428, Oncogene, England, C1-1

Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer

L Pereira, J Mariadason, R Hannan, A Dhillon

(2015), Vol. 5, Frontiers in Oncology, Switzerland, C1

A novel role for the pol I transcription factor ubtf in maintaining genome stability through the regulation of highly transcribed pol II genes

E Sanij, J Diesch, A Lesmana, G Poortinga, N Hein, G Lidgerwood, D Cameron, J Ellul, G Goodall, L Wong, A Dhillon, N Hamdane, L Rothblum, R Pearson, I Haviv, R Hannan

(2015), Vol. 25, pp. 201-212, Genome Research, United States, C1

Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression

G Advani, A Chueh, Y Lim, A Dhillon, H Cheng

(2015), Vol. 10, pp. 195-202, Frontiers in Biology, C1

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

O Gilan, J Diesch, M Amalia, K Jastrzebski, A Chueh, N Verrills, R Pearson, J Mariadason, E Tulchinsky, R Hannan, A Dhillon

(2015), Vol. 34, pp. 1333-1339, Oncogene, England, C1-1

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like Factor 5 (KLF5)-defendent manner

J Shin, A Carr, G Corner, L Tögel, M Dávaos-Salas, H Tran, A Chueh, S Al-Obaidi, F Chionh, N Ahmed, D Buchanan, J Young, M Malo, R Hodin, D Arango, O Sieber, L Augenlicht, A Dhillon, T Weber, J Mariadason

(2014), Vol. 289, pp. 25306-25316, Journal of Biological Chemistry, United States, C1

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

J Diesch, E Sanij, O Gilan, C Love, H Tran, N Fleming, J Ellul, M Amalia, I Haviv, R Pearson, E Tulchinsky, J Mariadason, O Sieber, R Hannan, A Dhillon

(2014), Vol. 9, PLoS ONE, C1-1

A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells

J Pakay, J Diesch, O Gilan, Y Yip, E Sayan, W Kolch, J Mariadason, R Hannan, E Tulchinsky, A Dhillon

(2012), Vol. 31, pp. 1817-1824, Oncogene, England, C1

Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL

A Sayan, R Stanford, R Vickery, E Grigorenko, J Diesch, K Kulbicki, R Edwards, R Pal, P Greaves, I Jariel-Encontre, M Piechaczyk, M Kriajevska, J Mellon, A Dhillon, E Tulchinsky

(2012), Vol. 31, pp. 1493-1503, Oncogene, England, C1-1

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

Y Yeap, I Ng, B Badrian, T Nguyen, Y Yip, A Dhillon, S Mutsaers, J Silke, M Bogoyevitch, D Ng

(2010), Vol. 430, pp. 345-354, Biochemical Journal, England, C1-1

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

A Dhillon, Y Yip, G Grindlay, J Pakay, M Dangers, M Hillmann, W Clark, A Pitt, H Mischak, W Kolch

(2009), Vol. 21, pp. 1645-1651, Cellular Signalling, England, C1-1

Snail is a repressor of RKIP transcription in metastatic prostate cancer cells

S Beach, H Tang, S Park, A Dhillon, E Keller, W Kolch, K Yeung

(2008), Vol. 27, pp. 2243-2248, Oncogene, England, C1-1

MAP kinase signalling pathways in cancer

A Dhillon, S Hagan, O Rath, W Kolch

(2007), Vol. 26, pp. 3279-3290, Oncogene, England, C1-1

Phosphatase and feedback regulation of Raf-1 signaling

A Dhillon, A Von Kriegsheim, J Grindlay, W Kolch

(2007), Vol. 6, pp. 3-7, Cell Cycle, United States, C1-1

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

A von Kriegsheim, A Pitt, G Grindlay, W Kolch, A Dhillon

(2006), Vol. 8, pp. 1011-1016, Nature Cell Biology, England, C1-1

Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells

C Pollock, S Shirasawa, T Sasazuki, W Kolch, A Dhillon

(2005), Vol. 65, pp. 1244-1250, Cancer Research, United States, C1-1

Dystroglycan, a scaffold for the ERK-MAP kinase cascade

H Spence, A Dhillon, M James, S Winder

(2004), Vol. 5, pp. 484-489, EMBO Reports, England, C1-1

A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation

A Dhillon, S Meikle, C Peyssonnaux, J Grindlay, C Kaiser, H Steen, P Shaw, H Mischak, A Eychène, W Kolch

(2003), Vol. 23, pp. 1983-1993, Molecular and Cellular Biology, United States, C1-1

Regulation of Raf-1 activation and signalling by dephosphorylation

A Dhillon, S Meikle, Z Yazici, M Eulitz, W Kolch

(2002), Vol. 21, pp. 64-71, EMBO Journal, England, C1-1

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259

A Dhillon, C Pollock, H Steen, P Shaw, H Mischak, W Kolch

(2002), Vol. 22, pp. 3237-3246, Molecular and Cellular Biology, United States, C1-1

Alcoholic myopathy: Biochemical mechanisms

V Preedy, A Paice, D Mantle, A Dhillon, T Palmer, T Peters

(2001), Vol. 63, pp. 199-205, Drug and Alcohol Dependence, Ireland, C1-1

Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κB activation

K Yeung, D Rose, A Dhillon, D Yaros, M Gustafsson, D Chatterjee, B McFerran, J Wyche, W Kolch, J Sedivy

(2001), Vol. 21, pp. 7207-7217, Molecular and Cellular Biology, United States, C1-1

Intact mitochondrial electron transport function is essential for signalling by hydrogen peroxide in cardiac myocytes

M Bogoyevitch, D Ng, N Court, K Draper, A Dhillon, L Abas

(2000), Vol. 32, pp. 1469-1480, Journal of Molecular and Cellular Cardiology, England, C1-1

Alcohol-related diols cause acute insulin resistance in vivo

D Xu, A Dhillon, A Abelmann, K Croft, T Peters, T Palmer

(1998), Vol. 47, pp. 1180-1186, Metabolism: Clinical and Experimental, United States, C1-1

Metabolic effects of alcohol on skeletal muscle

D Xu, A Dhillon, T Palmer

(1996), Vol. 1, pp. 143-155, Addiction Biology, United States, C1-1

Acute ethanol-mediated insulin resistance in the rat: The role of ethanol oxidation

A Dhillon, D Xu, T Palmer

(1996), Vol. 1, pp. 427-435, Addiction Biology, United States, C1-1

Alcohol and glucose metabolism in skeletal muscles in the rat

D Xu, A Dhillon, C Davey, P Fournier, T Palmer

(1996), Vol. 1, pp. 71-83, Addiction Biology, United States, C1-1

The transition from lipid to carbohydrate oxidation in response to re- feeding after starvation

D Xu, A Dhillon, P Drake, T Palmer

(1996), Vol. 16, pp. 1545-1553, Nutrition Research, C1-1