Dr Chiara Bortolasci

Metformin is Protective Against the Development of Mood Disorders

J Lake, C Bortolasci, A Stuart, J Pasco, S Kidnapillai, B Spolding, T Truong, B Panizzutti, Z Liu, O Dean, T Crowley, M Richardson, J Kim, M Berk, L Williams, K Walder

(2023), Vol. 56, pp. 25-31, Pharmacopsychiatry, C1

Lipopolysaccharide-binding protein and bone health: data from a population-based sample of men

J Cleminson, J Pasco, C Bortolasci, K Holloway-Kew, J Hodge, K Anderson, M Kotowicz, R Samarasinghe, L Williams

(2023), Vol. 34, pp. 309-317, Osteoporosis International, Berlin, Germany, C1

Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response

A Walker, M Mohebbi, M Maes, M Berk, K Walder, C Bortolasci, Z Liu, C Ng, M Ashton, L Berk, A Singh, G Malhi, O Dean

(2023), Vol. 27, Brain, Behavior, and Immunity - Health, C1

Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression

C Bortolasci, S Kidnapillai, B Spolding, T Truong, T Connor, C Swinton, B Panizzutti, Z Liu, A Sanigorski, O Dean, T Crowley, M Richardson, K Bozaoglu, K Vlahos, S Cowdery, B Watmuff, S Steyn, D Wolmarans, B Engelbrecht, C Perry, K Drummond, T Pang, S Jamain, L Gray, S McGee, B Harvey, J Kim, M Leboyer, M Berk, K Walder

(2023), Bipolar Disorders, C1

Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis

B Panizzutti, D Skvarc, S Lin, S Croce, A Meehan, C Bortolasci, W Marx, A Walker, K Hasebe, B Kavanagh, M Morris, M Mohebbi, A Turner, L Gray, L Berk, K Walder, M Berk, O Dean

(2023), Vol. 24, International Journal of Molecular Sciences, C1-1

Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen

C Bortolasci, E Jaehne, D Hernández, B Spolding, T Connor, B Panizzutti, O Dean, T Crowley, A Yung, L Gray, J Kim, M van den Buuse, M Berk, K Walder

(2023), pp. 1-12, Neurotoxicity Research, Berlin, Germany, C1

Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder

R Zazula, S Dodd, O Dean, M Berk, C Bortolasci, W Verri, H Vargas, S Nunes

(2022), Vol. 23, pp. 67-77, World Journal of Biological Psychiatry, England, C1

Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders

G Morris, K Walder, M Berk, A Carvalho, W Marx, C Bortolasci, A Yung, B Puri, M Maes

(2022), Vol. 114, pp. 1-17, Progress in Neuro-Psychopharmacology and Biological Psychiatry, Amsterdam, The Netherlands, C1

Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia

G Morris, L Sominsky, K Walder, M Berk, W Marx, A Carvalho, C Bortolasci, M Maes, B Puri

(2022), Vol. 59, pp. 3485-3503, Molecular Neurobiology, Berlin, Germany, C1

Common effects of bipolar disorder medications on expression quantitative trait loci genes

T Truong, C Bortolasci, S Kidnapillai, B Spolding, B Panizzutti, Z Liu, B Watmuff, J Kim, O Dean, M Richardson, M Berk, K Walder

(2022), Vol. 150, pp. 105-112, Journal of Psychiatric Research, Amsterdam, The Netherlands, C1

Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder

T Truong, C Bortolasci, B Spolding, B Panizzutti, Z Liu, S Kidnapillai, M Richardson, L Gray, C Smith, O Dean, J Kim, M Berk, K Walder

(2022), Vol. 13, Frontiers in Pharmacology, C1

Effects of psychotropic drugs on ribosomal genes and protein synthesis

Zoe Liu, Trang Truong, Chiara Bortolasci, Briana Spolding, Bruna Panizzutti, Courtney Swinton, Jee Kim, Srisaiyini Kidnapillai, Mark Richardson, Laura Gray, Olivia Dean, Sean McGee, Michael Berk, Ken Walder

(2022), Vol. 23, pp. 7180-7180, International Journal of Molecular Sciences, Basel, Switzerland, C1

Integrative analyses of transcriptomes to explore common molecular effects of antipsychotic drugs

Trang Truong, Chiara Bortolasci, Srisaiyini Kidnapillai, Briana Spolding, Bruna Panizzutti, Zoe Liu, Jee Kim, Olivia Dean, Mark Richardson, Michael Berk, Ken Walder

(2022), Vol. 23, pp. 7508-7508, International Journal of Molecular Sciences, Basel, Switzerland, C1

The role of metformin as a treatment for neuropsychiatric illness

S Dodd, L Sominsky, D Siskind, C Bortolasci, A Carvalho, M Maes, A Walker, K Walder, A Yung, L Williams, H Myles, T Watson, M Berk

(2022), Vol. 64, pp. 32-43, European Neuropsychopharmacology, Netherlands, C1

Effects of psychoactive drugs on cellular bioenergetic pathways

C Bortolasci, B Spolding, S Kidnapillai, M Richardson, N Vasilijevic, S Martin, L Gray, S McGee, M Berk, K Walder

(2021), Vol. 22, pp. 79-93, World Journal of Biological Psychiatry, England, C1

Systemic inflammation and grey matter volume in schizophrenia and bipolar disorder: Moderation by childhood trauma severity

Y Quidé, C Bortolasci, B Spolding, S Kidnapillai, O Watkeys, S Cohen-Woods, V Carr, M Berk, K Walder, M Green

(2021), Vol. 105, Progress in Neuro-Psychopharmacology and Biological Psychiatry, England, C1

Trace amine-associated receptor 1 (TAAR1): a new drug target for psychiatry?

S Dodd, A Carvalho, B Puri, M Maes, C Bortolasci, G Morris, M Berk

(2021), Vol. 120, pp. 537-541, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

Preventing the development of severe COVID-19 by modifying immunothrombosis

G Morris, C Bortolasci, B Puri, L Olive, W Marx, A O'Neil, E Athan, A Carvalho, M Maes, K Walder, M Berk

(2021), Vol. 264, Life Sciences, Netherlands, C1

The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders

Gerwyn Morris, B Puri, C Bortolasci, Andre Carvalho, M Berk, K Walder, E Moreira, M Maes

(2021), Vol. 125, pp. 244-263, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

Association between serum interleukin-6 and frailty in older men: cross-sectional data

M Tembo, K Holloway-Kew, C Bortolasci, S Brennan-Olsen, L Williams, M Kotowicz, J Pasco

(2021), Vol. 12, pp. 887-892, European Geriatric Medicine, Switzerland, C1

Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response

G Morris, E Gamage, N Travica, M Berk, F Jacka, A O'Neil, B Puri, A Carvalho, C Bortolasci, K Walder, W Marx

(2021), Vol. 172, pp. 101-122, Free radical biology and medicine, Amsterdam, The Netherlands, C1

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, C Bortolasci, B Puri, W Marx, A O'Neil, E Athan, K Walder, M Berk, L Olive, A Carvalho, M Maes

(2021), Vol. 144, Cytokine, England, C1

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

G Morris, K Walder, S Kloiber, P Amminger, M Berk, C Bortolasci, M Maes, B Puri, A Carvalho

(2021), Vol. 170, Pharmacological Research, Netherlands, C1

Transcriptional modulation of the hippo signaling pathway by drugs used to treat bipolar disorder and schizophrenia

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, G Morris, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 22, International Journal of Molecular Sciences, Switzerland, C1

Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial

C Bortolasci, A Turner, M Mohebbi, Z Liu, M Ashton, L Gray, W Marx, A Walker, G Kowalski, F Jacka, M Berk, O Dean, K Walder

(2021), Vol. 142, pp. 376-383, Journal of Psychiatric Research, England, C1

Biological mechanism(S) underpinning the association between antipsychotic drugs and weight gain

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 10, Journal of Clinical Medicine, Switzerland, C1

A placebo-controlled, randomised pilot trial of N-acetylcysteine or placebo for cessation of tobacco smoking

L Arancini, M Mohebbi, M Berk, O Dean, C Bortolasci, B Spolding, R Zazula, S Dodd

(2021), Vol. 53, pp. 120-126, European Neuropsychopharmacology, Amsterdam, The Netherlands, C1

Exploring interleukin-6, lipopolysaccharide binding protein and brain-derived neurotrophic factor following 12 weeks of adjunctive minocycline treatment for depression

K Hasebe, M Mohebbi, L Gray, A Walker, C Bortolasci, A Turner, M Berk, K Walder, M Maes, B Kanchanatawan, M Ashton, L Berk, C Ng, G Malhi, A Singh, O Dean

(2021), Vol. 34, Acta Neuropsychiatrica, England, C1

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

S Kidnapillai, C Bortolasci, M Udawela, B Panizzutti, B Spolding, T Connor, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, E Scarr, M Leboyer, B Dean, M Berk, K Walder

(2020), Vol. 21, pp. 775-783, World Journal of Biological Psychiatry, England, C1

Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurite outgrowth

S Kidnapillai, B Wade, C Bortolasci, B Panizzutti, B Spolding, T Connor, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2020), Vol. 34, pp. 370-379, Journal of Psychopharmacology, United States, C1

Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis

C Bortolasci, W Marx, A Walker, K Hasebe, B Kavanagh, M Morris, M Mohebbi, A Turner, L Gray, L Berk, K Walder, M Berk, O Dean

(2020), Vol. 10, pp. e035080-, BMJ open, England, C1

Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder

C Bortolasci, C Voigt, A Turner, M Mohebbi, L Gray, S Dodd, K Walder, M Berk, S Cotton, G Malhi, C Ng, N Dowling, J Sarris, O Dean

(2020), Vol. 32, pp. 313-320, Acta Neuropsychiatrica, England, C1

The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach

G Morris, C Bortolasci, B Puri, L Olive, W Marx, A O'Neil, E Athan, A Carvalho, M Maes, K Walder, M Berk

(2020), Vol. 258, Life Sciences, Netherlands, C1

Total Antioxidant Capacity and Frailty in Older Men

M Tembo, K Holloway-Kew, C Bortolasci, S Sui, S Brennan-Olsen, L Williams, M Kotowicz, J Pasco

(2020), Vol. 14, American Journal of Men's Health, United States, C1

Can endolysosomal deacidification and inhibition of autophagy prevent severe COVID-19?

G Morris, E Athan, K Walder, C Bortolasci, A O'Neil, W Marx, M Berk, A Carvalho, M Maes, B Puri

(2020), Vol. 262, Life Sciences, Netherlands, C1

Transcriptional effects of psychoactive drugs on genes involved in neurogenesis

C Bortolasci, B Spolding, S Kidnapillai, T Connor, T Truong, Z Liu, B Panizzutti, M Richardson, L Gray, M Berk, O Dean, K Walder

(2020), Vol. 21, pp. 1-19, International Journal of Molecular Sciences, Switzerland, C1

Exploring A-Acetylcysteine in Psychiatry

A Gimenez-Palomo, S Dodd, O Dean, C Bortolasci, M Berk

(2020), Vol. 37, pp. 48-51, Psychiatric Times, Santa Ana, Calif., C1-1

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

M Ashton, O Dean, A Walker, C Bortolasci, C Ng, M Hopwood, B Harvey, M Möller, J McGrath, W Marx, A Turner, S Dodd, J Scott, J Khoo, K Walder, J Sarris, M Berk

(2019), Vol. 10, Frontiers in Psychiatry, Switzerland, C1

The compensatory antioxidant response system with a focus on neuroprogressive disorders

G Morris, B Puri, A Walker, M Berk, K Walder, C Bortolasci, W Marx, A Carvalho, M Maes

(2019), Vol. 95, Progress in Neuro-Psychopharmacology and Biological Psychiatry, England, C1

N-acetylcysteine for cessation of tobacco smoking: Rationale and study protocol for a randomised controlled trial

L Arancini, C Bortolasci, S Dodd, O Dean, M Berk

(2019), Vol. 20, Trials, England, C1

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis - a possible therapeutic mechanism

S Kidnapillai, C Bortolasci, B Panizzutti, B Spolding, T Connor, K Bonifacio, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2019), Vol. 20, pp. 766-777, World Journal of Biological Psychiatry, London, Eng., C1

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

G Morris, B Puri, A Walker, M Maes, A Carvalho, C Bortolasci, K Walder, M Berk

(2019), Vol. 107, pp. 862-882, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

ENACT: A protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis

S Cotton, M Berk, A Watson, S Wood, K Allott, C Bartholomeusz, C Bortolasci, K Walder, B O'Donoghue, O Dean, A Chanen, G Amminger, P McGorry, A Burnside, J Uren, A Ratheesh, S Dodd

(2019), Vol. 20, Trials, England, C1

Mechanisms underpinning the polypharmacy effects of medications in psychiatry

C Bortolasci, B Spolding, E Callaly, S Martin, B Panizzutti, S Kidnapillai, T Connor, K Hasebe, M Mohebbi, O Dean, S McGee, S Dodd, L Gray, M Berk, K Walder

(2018), Vol. 21, pp. 582-591, International Journal of Neuropsychopharmacology, England, C1

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

B Panizzutti, C Bortolasci, K Hasebe, S Kidnapillai, L Gray, K Walder, M Berk, M Mohebbi, S Dodd, C Gama, P Magalhães, S Cotton, F Kapczinski, A Bush, G Malhi, O Dean

(2018), Vol. 30, pp. 334-341, Acta Neuropsychiatrica, England, C1

A review of the neurobiological underpinning of comorbid substance use and mood disorders

N Gómez-Coronado, R Sethi, C Bortolasci, L Arancini, M Berk, S Dodd

(2018), Vol. 241, pp. 388-401, Journal of Affective Disorders, Netherlands, C1

Adjunctive N-acetylcysteine in depression: Exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

K Hasebe, L Gray, C Bortolasci, B Panizzutti, M Mohebbi, S Kidnapillai, B Spolding, K Walder, M Berk, G Malhi, S Dodd, O Dean

(2017), Vol. 29, pp. 337-346, Acta Neuropsychiatrica, England, C1

Oxidative and nitrosative stress biomarkers in chronic schizophrenia

K Boll, C Noto, K Bonifácio, C Bortolasci, A Gadelha, R Bressan, D Barbosa, M Maes, E Moreira

(2017), Vol. 253, pp. 43-48, Psychiatry research, Amsterdam, The Netherlands, C1

Parkinson's disease is accompanied by intertwined alterations in iron metabolism and activated immune-inflammatory and oxidative stress pathways

C de Farias, M Maes, K Bonifácio, A Matsumoto, C Bortolasci, A Nogueira, F Brinholi, H Morimoto, L de Melo, E Moreira, D Barbosa

(2017), Vol. 16, pp. 484-491, CNS and neurological disorders - drug targets, Beijing, China, C1

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression : disease and staging biomarkers and new drug targets.

C de Fariasa, M Maes, K Bonifácio, C Bortolasci, A de Souza Nogueira, F Brinholi, A Matsumoto, M do Nascimento, L de Melo, S Nixdorf, E Lavado, E Moreira, D Barbosa

(2016), Vol. 617, pp. 66-71, Neuroscience letters, Amsterdam, The Netherlands, C1

Are PTH levels related to oxidative stress and inflammation in chronic kidney disease patients on hemodialysis?

Marcel Jaqueto, Vinicius Delfino, Chiara Bortolasci, Decio Barbosa, Helena Morimoto, Raquel Frange, Larissa Ferreira, Fernanda Guimarães

(2016), Vol. 38, pp. 288-295, Brazilian journal of nephrology, São Paulo, Brazil, C1

Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder

C Bortolasci, H Vargas, S Vargas Nunes, L de Melo, M de Castro, E Moreira, S Dodd, D Barbosa, M Berk, M Maes

(2015), Vol. 179, pp. 148-155, Journal of affective disorders, Amsterdam, The Netherlands, C1

Lowered plasma paraoxonase (PON) 1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism-smoking interactions differentially predict the odds of major depression and bipolar disorder

C Bortolasci, H Odebrecht Vargas, A Souza-Nogueira, D Barbosa, E Moreira, S Obedrecht Vargas Nunes, M Berk, S Dodd, M Maes

(2014), Vol. 159, pp. 23-30, Journal of affective disorders, Amsterdam, The Netherlands, C1

Paraoxonase 1 status and interactions between Q192R functional genotypes by smoking contribute significantly to total plasma radical trapping antioxidant potential.

C Bortolasci, M Maes, H Vargas, A Souza-Nogueira, E Moreira, S Nunes, M Berk, S Dodd, D Barbosa

(2014), Vol. 581, pp. 46-51, Neuroscience letters, Shannon, Ireland, C1

Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity

C Bortolasci, H Vargas, A Souza-Nogueira, E Gastaldello Moreira, S Vargas Nunes, M Berk, S Dodd, D Barbosa, M Maes

(2014), Vol. 19, pp. 232-241, Redox report, Leeds, England, C1

Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.

S Vargas Nunes, M Pizzo de Castro, E Moreira, R Guembarovski, D Barbosa, H Vargas, L Piccoli de Melo, C Bortolasci, M Watanabe, S Dodd, M Berk, M Maes

(2014), Vol. 585C, pp. 132-137, Neuroscience letters, Shannon, Ireland, C1

Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

K Boll, C Bortolasci, T Zaminelli, L Veríssimo, A Bacchi, L Higachi, D Barbosa, E Moreira

(2014), Vol. 50, pp. 353-359, Brazilian journal of pharmaceutical sciences, Sao Paulo, Brazil, C1-1

Oxidative stress and inflammatory markers are associated with depression and nicotine dependence

H Vargas, S Nunes, M de Castro, M Vargas, D Barbosa, C Bortolasci, K Venugopal, S Dodd, M Berk

(2013), Vol. 544, pp. 136-140, Neuroscience letters, Amsterdam, The Netherlands, C1

Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts

H Vargas, S Vargas Nunes, M de Castro, C Bortolasci, D Barbosa, H Morimoto, K Venugopal, S Dodd, M Maes, M Berk

(2013), Vol. 150, pp. 923-930, Journal of affective disorders, Amsterdam, The Netherlands, C1

Increased oxidative stress in foam cells obtained from hemodialysis patients

M Gonçalves, B Fabris, F Brinholi, C Bortolasci, M Watanabe, K Oliveira, V Delfino, E Lavado, D Barbosa

(2013), Vol. 17, pp. 266-274, Hemodialysis International, Hoboken, N.J., C1-1