Dr Chiara Bortolasci

STAFF PROFILE

Position

Alfred Deakin Postdoctoral Research Fellow

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Waurn Ponds Campus

Contact

chiara.b@deakin.edu.au
+61 3 524 79561

Biography

Dr Bortolasci is a pharmacist (2009), with a MSc (2012) and PhD (2015) in Health Sciences (State University of Londrina - Brazil). In 2014 she received a scholarship from the Brazilian Government to conduct her research in collaboration with the Metabolic Research Unit and IMPACT Strategic Research Centre, Deakin University. She completed her a Health Research Postdoctoral Fellowship in 2018 and she is currently an Alfred Deakin Postdoctoral Fellow, within the Metabolic Research Unit.

Read more on Chiara's profile

Affiliations

International Society for Stem Cell Research
Society for Mental Health Research
Biological Psychiatry
International College of Neuropsychopharmacology

Knowledge areas

Mental Health (Bipolar disorder, depression, and schizophrenia) 

Oxidative stress

Inflammation

Drug discovery

Stem cells

Awards

2018 – Rafaelsen Young Investigator Award - The International College of Neuropsychopharmacology
2017 – World Federation of the Societies of Biological Psychiatry Young Investigator Award

Projects

* Understanding the molecular alterations in bipolar disorder

* Mechanisms underpinning lithium response in bipolar disorder

* Repurposing drugs to treat bipolar disorder

* NAC for first episode psychosis

* NAC for smoking cessation

Publications

Filter by

2019

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Melanie Ashton, Olivia Dean, Adam Walker, Chiara Bortolasci, Chee Ng, Malcolm Hopwood, Brian Harvey, Marisa Mller, John McGrath, Wolfgang Marx, Alyna Turner, Seetal Dodd, James Scott, Jon-Paul Khoo, Ken Walder, Jerome Sarris, Michael Berk

(2019), Vol. 10, pp. 1-17, Frontiers in psychiatry, Lausanne, Switzerland, C1

journal

The compensatory antioxidant response system with a focus on neuroprogressive disorders

G Morris, B Puri, A Walker, M Berk, K Walder, C Bortolasci, W Marx, A Carvalho, M Maes

(2019), Vol. 95, Progress in neuro-psychopharmacology and biological psychiatry, Amsterdam, The Netherlands, C1

journal

N-acetylcysteine for cessation of tobacco smoking: rationale and study protocol for a randomised controlled trial

L Arancini, C Bortolasci, S Dodd, O Dean, M Berk

(2019), Vol. 20, pp. 1-7, Trials, London, Eng., C1

journal
2018

Mechanisms underpinning the polypharmacy effects of medications in psychiatry

Chiara Bortolasci, Briana Spolding, Edward Callaly, Sheree Martin, Bruna Panizzutti, Srisaiyini Kidnapillai, Timothy Connor, Kyoko Hasebe, Mohammadreza Mohebbi, Olivia Dean, Sean McGee, Seetal Dodd, Laura Gray, Michael Berk, Ken Walder

(2018), Vol. 21, pp. 582-591, The international journal of neuropsychopharmacology, Oxford, Eng., C1

journal

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

Srisaiyini Kidnapillai, Chiara Bortolasci, Madhara Udawela, Bruna Panizzutti, Briana Spolding, Timothy Connor, Andrew Sanigorski, Olivia Dean, Tamsyn Crowley, Stphane Jamain, Laura Gray, Elizabeth Scarr, Marion Leboyer, Brian Dean, Michael Berk, Ken Walder

(2018), pp. 1-9, World journal of biological psychiatry, London, Eng., C1

journal

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

Bruna Panizzutti, Chiara Bortolasci, Kyoko Hasebe, Srisaiyini Kidnapillai, Laura Gray, Ken Walder, Michael Berk, Mohammadreza Mohebbi, Seetal Dodd, Clarissa Gama, Pedro Magalhes, Susan Cotton, Flvio Kapczinski, Ashley Bush, Gin Malhi, Olivia Dean

(2018), Vol. 30, pp. 334-341, Acta neuropsychiatrica, Cambridge, Eng., C1

journal

A review of the neurobiological underpinning of comorbid substance use and mood disorders

Nieves Gmez-Coronado, Rickinder Sethi, Chiara Bortolasci, Lauren Arancini, Michael Berk, Seetal Dodd

(2018), Vol. 241, pp. 388-401, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal

Association between childhood trauma exposure and pro-inflammatory cytokines in schizophrenia and bipolar-I disorder

Yann Quid, Chiara Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Oliver Watkeys, Sarah Cohen-Woods, Michael Berk, Vaughan Carr, Ken Walder, Melissa Green

(2018), pp. 1-9, Psychological medicine, Cambridge, Eng., C1

journal
2017

Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

K Hasebe, L Gray, C Bortolasci, B Panizzutti, M Mohebbi, S Kidnapillai, B Spolding, K Walder, M Berk, G Malhi, S Dodd, O Dean

(2017), Vol. 29, pp. 337-346, Acta neuropsychiatrica, Cambridge, Eng., C1

journal

Oxidative and nitrosative stress biomarkers in chronic schizophrenia

K Boll, C Noto, K Bonifcio, C Bortolasci, A Gadelha, R Bressan, D Barbosa, M Maes, E Moreira

(2017), Vol. 253, pp. 43-48, Psychiatry research, Amsterdam, The Netherlands, C1

journal

Parkinson's disease is accompanied by intertwined alterations in iron metabolism and activated immune-inflammatory and oxidative stress pathways

C de Farias, M Maes, K Bonifcio, A Matsumoto, C Bortolasci, A Nogueira, F Brinholi, H Morimoto, L de Melo, E Moreira, D Barbosa

(2017), Vol. 16, pp. 484-491, CNS and neurological disorders - drug targets, Beijing, China, C1

journal
2016

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression : disease and staging biomarkers and new drug targets.

C de Fariasa, M Maes, K Bonifcio, C Bortolasci, A de Souza Nogueira, F Brinholi, A Matsumoto, M do Nascimento, L de Melo, S Nixdorf, E Lavado, E Moreira, D Barbosa

(2016), Vol. 617, pp. 66-71, Neuroscience letters, Amsterdam, The Netherlands, C1

journal

Are PTH levels related to oxidative stress and inflammation in chronic kidney disease patients on hemodialysis?

Marcel Jaqueto, Vinicius Delfino, Chiara Bortolasci, Decio Barbosa, Helena Morimoto, Raquel Frange, Larissa Ferreira, Fernanda Guimares

(2016), Vol. 38, pp. 288-295, Brazilian journal of nephrology, So Paulo, Brazil, C1

journal
2015

Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder

C Bortolasci, H Vargas, S Vargas Nunes, L de Melo, M de Castro, E Moreira, S Dodd, D Barbosa, M Berk, M Maes

(2015), Vol. 179, pp. 148-155, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal
2014

Lowered plasma paraoxonase (PON) 1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism-smoking interactions differentially predict the odds of major depression and bipolar disorder

C Bortolasci, H Odebrecht Vargas, A Souza-Nogueira, D Barbosa, E Moreira, S Obedrecht Vargas Nunes, M Berk, S Dodd, M Maes

(2014), Vol. 159, pp. 23-30, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal

Paraoxonase 1 status and interactions between Q192R functional genotypes by smoking contribute significantly to total plasma radical trapping antioxidant potential.

C Bortolasci, M Maes, H Vargas, A Souza-Nogueira, E Moreira, S Nunes, M Berk, S Dodd, D Barbosa

(2014), Vol. 581, pp. 46-51, Neuroscience letters, Shannon, Ireland, C1

journal

Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity

C Bortolasci, H Vargas, A Souza-Nogueira, E Gastaldello Moreira, S Vargas Nunes, M Berk, S Dodd, D Barbosa, M Maes

(2014), Vol. 19, pp. 232-241, Redox report, Leeds, England, C1

journal

Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.

S Vargas Nunes, M Pizzo de Castro, E Moreira, R Guembarovski, D Barbosa, H Vargas, L Piccoli de Melo, C Bortolasci, M Watanabe, S Dodd, M Berk, M Maes

(2014), Vol. 585C, pp. 132-137, Neuroscience letters, Shannon, Ireland, C1

journal

Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

K Boll, C Bortolasci, T Zaminelli, L Verssimo, A Bacchi, L Higachi, D Barbosa, E Moreira

(2014), Vol. 50, pp. 353-359, Brazilian journal of pharmaceutical sciences, Sao Paulo, Brazil, C1-1

journal
2013

Oxidative stress and inflammatory markers are associated with depression and nicotine dependence

H Vargas, S Nunes, M de Castro, M Vargas, D Barbosa, C Bortolasci, K Venugopal, S Dodd, M Berk

(2013), Vol. 544, pp. 136-140, Neuroscience Letters, C1

journal

Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts

H Vargas, S Nunes, M De Castro, C Bortolasci, D Barbosa, H Morimoto, K Venugopal, S Doddd, M Maes, M Berk

(2013), Vol. 150, pp. 923-930, Journal of Affective Disorders, C1

journal

Increased oxidative stress in foam cells obtained from hemodialysis patients

M Gonalves, B Fabris, F Brinholi, C Bortolasci, M Watanabe, K Oliveira, V Delfino, E Lavado, D Barbosa

(2013), Vol. 17, pp. 266-274, Hemodialysis International, Hoboken, N.J., C1-1

journal

Funded Projects at Deakin

Industry and Other Funding

Understanding the mechanisms underpinning lithium response

Dr Chiara Bortolasci

  • 2019: $7,618

Supervisions

Associate Supervisor
2018

Srisaiyini Kidnapillai

Thesis entitled: Molecular Mechanisms of Action of Drugs Used to Treat Bipolar Disorder

Doctor of Philosophy (Medicine), School of Medicine