Dr Chiara Bortolasci

STAFF PROFILE

Position

Affiliate Senior Lecturer

Faculty

Faculty of Health

Department

School of Medicine

Campus

Geelong Clinical School

Contact

chiara.b@deakin.edu.au
+61 3 524 79561

Biography

Dr Bortolasci is a pharmacist (2009), with a MSc (2012) and PhD (2015) in Health Sciences (State University of Londrina - Brazil). In 2014 she received a scholarship from the Brazilian Government to conduct her research in collaboration with the Metabolic Research Unit and IMPACT Strategic Research Centre, Deakin University. She completed her a Health Research Postdoctoral Fellowship in 2018 and she is currently an Alfred Deakin Postdoctoral Fellow, within the Metabolic Research Unit.

Read more on Chiara's profile

Affiliations

International Society for Stem Cell Research
Society for Mental Health Research
Biological Psychiatry
International College of Neuropsychopharmacology

Knowledge areas

Mental Health (Bipolar disorder, depression, and schizophrenia) 

Oxidative stress

Inflammation

Drug discovery

Stem cells

Awards

2018 – Rafaelsen Young Investigator Award - The International College of Neuropsychopharmacology
2017 – World Federation of the Societies of Biological Psychiatry Young Investigator Award

Projects

* Understanding the molecular alterations in bipolar disorder

* Mechanisms underpinning lithium response in bipolar disorder

* Repurposing drugs to treat bipolar disorder

* NAC for first episode psychosis

* NAC for smoking cessation

Publications

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2022

Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder

R Zazula, S Dodd, O Dean, M Berk, C Bortolasci, W Verri, H Vargas, S Nunes

(2022), Vol. 23, pp. 67-77, World Journal of Biological Psychiatry, England, C1

journal article

Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders

G Morris, K Walder, M Berk, A Carvalho, W Marx, C Bortolasci, A Yung, B Puri, M Maes

(2022), Vol. 114, pp. 1-17, Progress in Neuro-Psychopharmacology and Biological Psychiatry, Amsterdam, The Netherlands, C1

journal article

Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia

G Morris, L Sominsky, K Walder, M Berk, W Marx, A Carvalho, C Bortolasci, M Maes, B Puri

(2022), Molecular Neurobiology, C1

journal article

Common effects of bipolar disorder medications on expression quantitative trait loci genes

T Truong, C Bortolasci, S Kidnapillai, B Spolding, B Panizzutti, Z Liu, B Watmuff, J Kim, O Dean, M Richardson, M Berk, K Walder

(2022), Vol. 150, pp. 105-112, Journal of Psychiatric Research, Amsterdam, The Netherlands, C1

journal article

Co-Expression Networks Unveiled Long Non-Coding RNAs as Molecular Targets of Drugs Used to Treat Bipolar Disorder

Trang Truong, Chiara Bortolasci, Briana Spolding, Bruna Panizzutti, Zoe Liu, Srisaiyini Kidnapillai, Mark Richardson, Laura Gray, Craig Smith, Olivia Dean, Jee Kim, Michael Berk, Ken Walder

(2022), Vol. 13, pp. 1-12, Frontiers in Pharmacology, Lausanne, Switzerland, C1

journal article
2021

Effects of psychoactive drugs on cellular bioenergetic pathways

C Bortolasci, B Spolding, S Kidnapillai, M Richardson, N Vasilijevic, S Martin, L Gray, S McGee, M Berk, K Walder

(2021), Vol. 22, pp. 79-93, World Journal of Biological Psychiatry, England, C1

journal article

Systemic inflammation and grey matter volume in schizophrenia and bipolar disorder: moderation by childhood trauma severity

Y Quidé, C Bortolasci, B Spolding, S Kidnapillai, O Watkeys, S Cohen-Woods, V Carr, M Berk, K Walder, M Green

(2021), Vol. 105, pp. 1-10, Progress in neuro-psychopharmacology and biological psychiatry, Amsterdam, The Netherlands, C1

journal article

Trace amine-associated receptor 1 (TAAR1): a new drug target for psychiatry?

S Dodd, A Carvalho, B Puri, M Maes, C Bortolasci, G Morris, M Berk

(2021), Vol. 120, pp. 537-541, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

Preventing the development of severe COVID-19 by modifying immunothrombosis

G Morris, C Bortolasci, B Puri, L Olive, W Marx, A O'Neil, E Athan, A Carvalho, M Maes, K Walder, M Berk

(2021), Vol. 264, pp. 1-15, Life sciences, Amsterdam, The Netherlands, C1

journal article

The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders

Gerwyn Morris, B Puri, C Bortolasci, Andre Carvalho, M Berk, K Walder, E Moreira, M Maes

(2021), Vol. 125, pp. 244-263, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

Association between serum interleukin-6 and frailty in older men: cross-sectional data

M Tembo, K Holloway-Kew, C Bortolasci, S Brennan-Olsen, L Williams, M Kotowicz, J Pasco

(2021), Vol. 12, pp. 887-892, European Geriatric Medicine, Switzerland, C1

journal article

Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response

G Morris, E Gamage, N Travica, M Berk, F Jacka, A O'Neil, B Puri, A Carvalho, C Bortolasci, K Walder, W Marx

(2021), Vol. 172, pp. 101-122, Free radical biology and medicine, Amsterdam, The Netherlands, C1

journal article

The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all?

G Morris, C Bortolasci, B Puri, W Marx, A O'Neil, E Athan, K Walder, M Berk, L Olive, A Carvalho, M Maes

(2021), Vol. 144, pp. 1-18, Cytokine, Amsterdam, The Netherlands, C1

journal article

The endocannabinoidome in neuropsychiatry: Opportunities and potential risks

G Morris, K Walder, S Kloiber, P Amminger, M Berk, C Bortolasci, M Maes, B Puri, A Carvalho

(2021), Vol. 170, pp. 1-24, Pharmacological Research, Amsterdam, The Netherlands, C1

journal article

Transcriptional modulation of the hippo signaling pathway by drugs used to treat bipolar disorder and schizophrenia

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, G Morris, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 22, pp. 1-16, International Journal of Molecular Sciences, Basel, Switzerland, C1

journal article

Baseline serum amino acid levels predict treatment response to augmentation with N-acetylcysteine (NAC) in a bipolar disorder randomised trial

C Bortolasci, A Turner, M Mohebbi, Z Liu, M Ashton, L Gray, W Marx, A Walker, G Kowalski, F Jacka, M Berk, O Dean, K Walder

(2021), Vol. 142, pp. 376-383, Journal of Psychiatric Research, Amsterdam, The Netherlands, C1

journal article

Biological mechanism(S) underpinning the association between antipsychotic drugs and weight gain

B Panizzutti, C Bortolasci, B Spolding, S Kidnapillai, T Connor, M Richardson, T Truong, Z Liu, L Gray, J Kim, O Dean, M Berk, K Walder

(2021), Vol. 10, pp. 1-8, Journal of Clinical Medicine, Basel, Switzerland, C1

journal article

A placebo-controlled, randomised pilot trial of N-acetylcysteine or placebo for cessation of tobacco smoking

L Arancini, M Mohebbi, M Berk, O Dean, C Bortolasci, B Spolding, R Zazula, S Dodd

(2021), Vol. 53, pp. 120-126, European Neuropsychopharmacology, Amsterdam, The Netherlands, C1

journal article

Exploring interleukin-6, lipopolysaccharide binding protein and brain-derived neurotrophic factor following 12 weeks of adjunctive minocycline treatment for depression

K Hasebe, M Mohebbi, L Gray, A Walker, C Bortolasci, A Turner, M Berk, K Walder, M Maes, B Kanchanatawan, M Ashton, L Berk, C Ng, G Malhi, A Singh, O Dean

(2021), pp. 1-8, Acta Neuropsychiatrica, Cambridge, Eng., C1

journal article
2020

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

S Kidnapillai, C Bortolasci, M Udawela, B Panizzutti, B Spolding, T Connor, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, E Scarr, M Leboyer, B Dean, M Berk, K Walder

(2020), Vol. 21, pp. 775-783, World Journal of Biological Psychiatry, England, C1

journal article

Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurite outgrowth

S Kidnapillai, B Wade, C Bortolasci, B Panizzutti, B Spolding, T Connor, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2020), Vol. 34, pp. 370-379, Journal of psychopharmacology, London, Eng., C1

journal article

Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis

C Bortolasci, W Marx, A Walker, K Hasebe, B Kavanagh, M Morris, M Mohebbi, A Turner, L Gray, L Berk, K Walder, M Berk, O Dean

(2020), Vol. 10, pp. 1-4, BMJ open, London, Eng., C1

journal article

Interleukin-6 and total antioxidant capacity levels following N-acetylcysteine and a combination nutraceutical intervention in a randomised controlled trial for bipolar disorder

C Bortolasci, C Voigt, A Turner, M Mohebbi, L Gray, S Dodd, K Walder, M Berk, S Cotton, G Malhi, C Ng, N Dowling, J Sarris, O Dean

(2020), Vol. 32, pp. 313-320, Acta Neuropsychiatrica, Cambridge, Eng., C1

journal article

The pathophysiology of SARS-CoV-2: a suggested model and therapeutic approach

G Morris, C Bortolasci, B Puri, L Olive, W Marx, A O'Neil, E Athan, A Carvalho, M Maes, K Walder, M Berk

(2020), Vol. 258, pp. 1-15, Life sciences, Amsterdam, The Netherlands, C1

journal article

Total Antioxidant Capacity and Frailty in Older Men

M Tembo, K Holloway-Kew, C Bortolasci, S Sui, S Brennan-Olsen, L Williams, M Kotowicz, J Pasco

(2020), pp. 1-6, American Journal of Men's Health, London, Eng., C1

journal article

Can endolysosomal deacidification and inhibition of autophagy prevent severe COVID-19?

G Morris, E Athan, K Walder, C Bortolasci, A O'Neil, W Marx, M Berk, A Carvalho, M Maes, B Puri

(2020), Vol. 262, pp. 1-14, Life sciences, Amsterdam, The Netherlands, C1

journal article

Transcriptional effects of psychoactive drugs on genes involved in neurogenesis

Chiara Bortolasci, Briana Randall, Srisaiyini Kidnapillai, Timothy Connor, Trang Truong, Z Liu, Bruna Panizzutti Parry, Mark Richardson, Laura Gray, Michael Berk, Olivia Dean, Ken Walder

(2020), Vol. 21, International Journal of Molecular Sciences, Basel, Switzerland, C1

journal article
2019

Association between childhood trauma exposure and pro-inflammatory cytokines in schizophrenia and bipolar-I disorder

Yann Quidé, Chiara Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Oliver Watkeys, Sarah Cohen-Woods, Michael Berk, Vaughan Carr, Ken Walder, Melissa Green

(2019), Vol. 49, pp. 2736-2744, Psychological medicine, Cambridge, Eng., C1

journal article

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Melanie Ashton, Olivia Dean, Adam Walker, Chiara Bortolasci, Chee Ng, Malcolm Hopwood, Brian Harvey, Marisa Möller, John McGrath, Wolfgang Marx, Alyna Turner, Seetal Dodd, James Scott, Jon-Paul Khoo, Ken Walder, Jerome Sarris, Michael Berk

(2019), Vol. 10, pp. 1-17, Frontiers in psychiatry, Lausanne, Switzerland, C1

journal article

The compensatory antioxidant response system with a focus on neuroprogressive disorders

G Morris, B Puri, A Walker, M Berk, K Walder, C Bortolasci, W Marx, A Carvalho, M Maes

(2019), Vol. 95, Progress in neuro-psychopharmacology and biological psychiatry, Amsterdam, The Netherlands, C1

journal article

N-acetylcysteine for cessation of tobacco smoking: rationale and study protocol for a randomised controlled trial

L Arancini, C Bortolasci, S Dodd, O Dean, M Berk

(2019), Vol. 20, pp. 1-7, Trials, London, Eng., C1

journal article

Drugs used in the treatment of bipolar disorder and their effects on cholesterol biosynthesis - a possible therapeutic mechanism

S Kidnapillai, C Bortolasci, B Panizzutti, B Spolding, T Connor, K Bonifacio, A Sanigorski, O Dean, T Crowley, S Jamain, L Gray, M Leboyer, M Berk, K Walder

(2019), Vol. 20, pp. 766-777, World Journal of Biological Psychiatry, London, Eng., C1

journal article

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

G Morris, B Puri, A Walker, M Maes, A Carvalho, C Bortolasci, K Walder, M Berk

(2019), Vol. 107, pp. 862-882, Neuroscience and biobehavioral reviews, Amsterdam, The Netherlands, C1

journal article

ENACT: a protocol for a randomised placebo-controlled trial investigating the efficacy and mechanisms of action of adjunctive N-acetylcysteine for first-episode psychosis

S Cotton, M Berk, A Watson, S Wood, K Allott, C Bartholomeusz, C Bortolasci, K Walder, B O'Donoghue, O Dean, A Chanen, G Amminger, P McGorry, A Burnside, J Uren, A Ratheesh, S Dodd

(2019), Vol. 20, pp. 1-14, Trials, London, Eng., C1

journal article
2018

Mechanisms underpinning the polypharmacy effects of medications in psychiatry

Chiara Bortolasci, Briana Spolding, Edward Callaly, Sheree Martin, Bruna Panizzutti, Srisaiyini Kidnapillai, Timothy Connor, Kyoko Hasebe, Mohammadreza Mohebbi, Olivia Dean, Sean McGee, Seetal Dodd, Laura Gray, Michael Berk, Ken Walder

(2018), Vol. 21, pp. 582-591, The international journal of neuropsychopharmacology, Oxford, Eng., C1

journal article

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

Bruna Panizzutti, Chiara Bortolasci, Kyoko Hasebe, Srisaiyini Kidnapillai, Laura Gray, Ken Walder, Michael Berk, Mohammadreza Mohebbi, Seetal Dodd, Clarissa Gama, Pedro Magalhães, Susan Cotton, Flávio Kapczinski, Ashley Bush, Gin Malhi, Olivia Dean

(2018), Vol. 30, pp. 334-341, Acta neuropsychiatrica, Cambridge, Eng., C1

journal article

A review of the neurobiological underpinning of comorbid substance use and mood disorders

Nieves Gómez-Coronado, Rickinder Sethi, Chiara Bortolasci, Lauren Arancini, Michael Berk, Seetal Dodd

(2018), Vol. 241, pp. 388-401, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal article
2017

Adjunctive N-acetylcysteine in depression: exploration of interleukin-6, C-reactive protein and brain-derived neurotrophic factor

K Hasebe, L Gray, C Bortolasci, B Panizzutti, M Mohebbi, S Kidnapillai, B Spolding, K Walder, M Berk, G Malhi, S Dodd, O Dean

(2017), Vol. 29, pp. 337-346, Acta neuropsychiatrica, Cambridge, Eng., C1

journal article

Oxidative and nitrosative stress biomarkers in chronic schizophrenia

K Boll, C Noto, K Bonifácio, C Bortolasci, A Gadelha, R Bressan, D Barbosa, M Maes, E Moreira

(2017), Vol. 253, pp. 43-48, Psychiatry research, Amsterdam, The Netherlands, C1

journal article

Parkinson's disease is accompanied by intertwined alterations in iron metabolism and activated immune-inflammatory and oxidative stress pathways

C de Farias, M Maes, K Bonifácio, A Matsumoto, C Bortolasci, A Nogueira, F Brinholi, H Morimoto, L de Melo, E Moreira, D Barbosa

(2017), Vol. 16, pp. 484-491, CNS and neurological disorders - drug targets, Beijing, China, C1

journal article
2016

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression : disease and staging biomarkers and new drug targets.

C de Fariasa, M Maes, K Bonifácio, C Bortolasci, A de Souza Nogueira, F Brinholi, A Matsumoto, M do Nascimento, L de Melo, S Nixdorf, E Lavado, E Moreira, D Barbosa

(2016), Vol. 617, pp. 66-71, Neuroscience letters, Amsterdam, The Netherlands, C1

journal article

Are PTH levels related to oxidative stress and inflammation in chronic kidney disease patients on hemodialysis?

Marcel Jaqueto, Vinicius Delfino, Chiara Bortolasci, Decio Barbosa, Helena Morimoto, Raquel Frange, Larissa Ferreira, Fernanda Guimarães

(2016), Vol. 38, pp. 288-295, Brazilian journal of nephrology, São Paulo, Brazil, C1

journal article
2015

Factors influencing insulin resistance in relation to atherogenicity in mood disorders, the metabolic syndrome and tobacco use disorder

C Bortolasci, H Vargas, S Vargas Nunes, L de Melo, M de Castro, E Moreira, S Dodd, D Barbosa, M Berk, M Maes

(2015), Vol. 179, pp. 148-155, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal article
2014

Is there an actual benefit in antioxidant supplementation on cancer treatment?

D Barbosa, D Venturini, F Brinholi, A Matsumoto, C de Farias, C Bortolasci, K Bonifácio, L Higachi

(2014), pp. 29-74, Free Radicals: The Role of Antioxidants and Pro-oxidants in Cancer Development, B1-1

book chapter

Lowered plasma paraoxonase (PON) 1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism-smoking interactions differentially predict the odds of major depression and bipolar disorder

C Bortolasci, H Odebrecht Vargas, A Souza-Nogueira, D Barbosa, E Moreira, S Obedrecht Vargas Nunes, M Berk, S Dodd, M Maes

(2014), Vol. 159, pp. 23-30, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal article

Paraoxonase 1 status and interactions between Q192R functional genotypes by smoking contribute significantly to total plasma radical trapping antioxidant potential.

C Bortolasci, M Maes, H Vargas, A Souza-Nogueira, E Moreira, S Nunes, M Berk, S Dodd, D Barbosa

(2014), Vol. 581, pp. 46-51, Neuroscience letters, Shannon, Ireland, C1

journal article

Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity

C Bortolasci, H Vargas, A Souza-Nogueira, E Gastaldello Moreira, S Vargas Nunes, M Berk, S Dodd, D Barbosa, M Maes

(2014), Vol. 19, pp. 232-241, Redox report, Leeds, England, C1

journal article

Association of paraoxonase (PON)1 activity, glutathione S-transferase GST T1/M1 and STin.2 polymorphisms with comorbidity of tobacco use disorder and mood disorders.

S Vargas Nunes, M Pizzo de Castro, E Moreira, R Guembarovski, D Barbosa, H Vargas, L Piccoli de Melo, C Bortolasci, M Watanabe, S Dodd, M Berk, M Maes

(2014), Vol. 585C, pp. 132-137, Neuroscience letters, Shannon, Ireland, C1

journal article

Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

K Boll, C Bortolasci, T Zaminelli, L Veríssimo, A Bacchi, L Higachi, D Barbosa, E Moreira

(2014), Vol. 50, pp. 353-359, Brazilian journal of pharmaceutical sciences, Sao Paulo, Brazil, C1-1

journal article
2013

Oxidative stress and inflammatory markers are associated with depression and nicotine dependence

H Vargas, S Nunes, M de Castro, M Vargas, D Barbosa, C Bortolasci, K Venugopal, S Dodd, M Berk

(2013), Vol. 544, pp. 136-140, Neuroscience letters, Amsterdam, The Netherlands, C1

journal article

Oxidative stress and lowered total antioxidant status are associated with a history of suicide attempts

H Vargas, S Vargas Nunes, M de Castro, C Bortolasci, D Barbosa, H Morimoto, K Venugopal, S Dodd, M Maes, M Berk

(2013), Vol. 150, pp. 923-930, Journal of affective disorders, Amsterdam, The Netherlands, C1

journal article

Increased oxidative stress in foam cells obtained from hemodialysis patients

M Gonçalves, B Fabris, F Brinholi, C Bortolasci, M Watanabe, K Oliveira, V Delfino, E Lavado, D Barbosa

(2013), Vol. 17, pp. 266-274, Hemodialysis International, Hoboken, N.J., C1-1

journal article

Funded Projects at Deakin

Australian Competitive Grants

The efficacy of N-acetyl cysteine as an adjunctive treatment for first episode psychosis

A/Prof Susan Cotton, Dr Seetal Dodd, Prof Stephen Wood, Dr Kelly Allott, Dr Cali Bartholomeusz, Dr Chiara Bortolasci, Dr Brian O'Donoghue, Dr Aswin Ratheesh

NHMRC Project Grant

  • 2021: $13,750

Using 'omics to unravel the pathophysiology and repurpose drugs to treat ME/CFS

Prof Ken Walder, Prof Michael Berk, Dr Chiara Bortolasci, Prof Sean Mcgee, Prof Clinton Bruce, Dr Wolf Marx

NHMRC Targeted Call for Research into Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Grant Opportunity

  • 2022: $55,097
  • 2021: $152,361
  • 2020: $25,320

Industry and Other Funding

Understanding the mechanisms underpinning lithium response

Dr Chiara Bortolasci

  • 2019: $7,618

Repurposing drugs to treat bipolar depression using stem cell technology

Prof Ken Walder, Dr Chiara Bortolasci, Prof Michael Berk, Dr Amy Sinclair

  • 2022: $257,128

Supervisions

Associate Supervisor
2018

Srisaiyini Kidnapillai

Thesis entitled: Molecular Mechanisms of Action of Drugs Used to Treat Bipolar Disorder

Doctor of Philosophy (Medicine), School of Medicine